{
"uniprot_canonical_ac": "P11712-1",
"uniprot_ac": "P11712",
"uniprot_id": "CP2C9_HUMAN",
"mass": {
"chemical_mass": 55628.0,
"monoisotopic_mass": 55628.0
},
"refseq": {
"ac": "NP_000762",
"name": "cytochrome P450 2C9",
"summary": "This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008].",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000762"
},
"gene_names": [
{
"name": "CYP2C9",
"resource": "UniProtKB",
"type": "recommended",
"url": "https://www.uniprot.org/uniprot/P11712",
"id": "P11712"
},
{
"name": "CPC9; CYP2C; CYP2C10; CYPIIC9; P450-2C9; P450IIC9",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000762",
"id": "NP_000762"
},
{
"name": "CYP2C10",
"resource": "UniProtKB",
"type": "synonym",
"url": "https://www.uniprot.org/uniprot/P11712",
"id": "P11712"
},
{
"name": "CYP2C9",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000762",
"id": "NP_000762"
}
],
"protein_names": [
{
"name": "Cytochrome P450 2C9",
"resource": "UniProtKB",
"type": "recommended",
"url": "",
"id": "P11712"
},
{
"name": "(R)-limonene 6-monooxygenase",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P11712"
},
{
"name": "(S)-limonene 6-monooxygenase",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P11712"
},
{
"name": "(S)-limonene 7-monooxygenase",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P11712"
},
{
"name": "1.14.14.1",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P11712"
},
{
"name": "1.14.14.51",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P11712"
},
{
"name": "1.14.14.52",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P11712"
},
{
"name": "1.14.14.53",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P11712"
},
{
"name": "CYPIIC9",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P11712"
},
{
"name": "Cholesterol 25-hydroxylase",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P11712"
},
{
"name": "Cytochrome P-450MP",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P11712"
},
{
"name": "Cytochrome P450 MP-4",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P11712"
},
{
"name": "Cytochrome P450 MP-8",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P11712"
},
{
"name": "Cytochrome P450 PB-1",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P11712"
},
{
"name": "S-mephenytoin 4-hydroxylase",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P11712"
},
{
"name": "cytochrome P450 2C9",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000762",
"id": "NP_000762"
},
{
"name": "microsomal monooxygenase; xenobiotic monooxygenase; flavoprotein-linked monooxygenase; cytochrome P-450 S-mephenytoin 4-hydroxylase; cytochrome P-450MP; cytochrome P450 PB-1; cytochrome P450, family 2, subfamily C, polypeptide 9",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000762",
"id": "NP_000762"
}
],
"function": [
{
"annotation": "A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids (PubMed:7574697, PubMed:9866708, PubMed:9435160, PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:7574697, PubMed:9866708, PubMed:9435160, PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) (PubMed:7574697, PubMed:15766564, PubMed:19965576, PubMed:9866708). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). Exhibits low catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317). Catalyzes bisallylic hydroxylation and hydroxylation with double-bond migration of polyunsaturated fatty acids (PUFA) (PubMed:9866708, PubMed:9435160). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794). Contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031).",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712#function"
},
{
"database": "PubMed",
"id": "25994031",
"url": "https://glygen.org/publication/PubMed/25994031"
},
{
"database": "PubMed",
"id": "11950794",
"url": "https://glygen.org/publication/PubMed/11950794"
},
{
"database": "PubMed",
"id": "15766564",
"url": "https://glygen.org/publication/PubMed/15766564"
},
{
"database": "PubMed",
"id": "9435160",
"url": "https://glygen.org/publication/PubMed/9435160"
},
{
"database": "PubMed",
"id": "7574697",
"url": "https://glygen.org/publication/PubMed/7574697"
},
{
"database": "PubMed",
"id": "21576599",
"url": "https://glygen.org/publication/PubMed/21576599"
},
{
"database": "PubMed",
"id": "19965576",
"url": "https://glygen.org/publication/PubMed/19965576"
},
{
"database": "PubMed",
"id": "12865317",
"url": "https://glygen.org/publication/PubMed/12865317"
},
{
"database": "PubMed",
"id": "9866708",
"url": "https://glygen.org/publication/PubMed/9866708"
}
]
},
{
"annotation": "Effects of CYP3A4 and CYP2C9 genotype on systemic anastrozole and fulvestrant concentrations in SWOG S0226.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000762",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000762"
},
{
"database": "PubMed",
"id": "37615099",
"url": "https://glygen.org/publication/PubMed/37615099"
}
]
},
{
"annotation": "FREQUENCY OF VKORC1 AND CYP2C9 GENES POLYMORPHISM IN ABKHAZIAN POPULATION.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000762",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000762"
},
{
"database": "PubMed",
"id": "37419479",
"url": "https://glygen.org/publication/PubMed/37419479"
}
]
},
{
"annotation": "Frequency of polymorphisms in the CYP2C9, VKORC1, and CYP4F2 genes related to the metabolism of Warfarin in healthy donors from Cali, Colombia.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000762",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000762"
},
{
"database": "PubMed",
"id": "37505171",
"url": "https://glygen.org/publication/PubMed/37505171"
}
]
},
{
"annotation": "Impact of CYP2C9*2 and *3 polymorphisms on valproate-associated adverse drug reactions in individuals living with epilepsy: a case-control study.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000762",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000762"
},
{
"database": "PubMed",
"id": "37811569",
"url": "https://glygen.org/publication/PubMed/37811569"
}
]
},
{
"annotation": "The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000762",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000762"
},
{
"database": "PubMed",
"id": "37584614",
"url": "https://glygen.org/publication/PubMed/37584614"
}
]
},
{
"annotation": "This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008].",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000762",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000762"
}
]
}
],
"disease": [],
"snv": [
{
"evidence": [
{
"id": "P11712",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P11712"
}
],
"glycoeffect": [],
"start_pos": 335,
"end_pos": 335,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "R",
"sequence_mut": "Q",
"comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).",
"chr_id": "10",
"chr_pos": "94981225",
"ref_nt": "G",
"alt_nt": "A",
"minor_allelic_frequency": "",
"site_lbl": "R335",
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
},
{
"disease_id": "DOID:1115",
"recommended_name": {
"id": "DOID:1115",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1115",
"name": "sarcoma",
"description": "A cell type cancer that has_material_basis_in abnormally proliferating cells derives from embryonic mesoderm."
},
"synonyms": [
{
"id": "DOID:1115",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1115",
"name": "connective and soft tissue neoplasm",
"description": ""
},
{
"id": "DOID:1115",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1115",
"name": "tumor of soft tissue and skeleton",
"description": ""
}
]
},
{
"disease_id": "DOID:4159",
"recommended_name": {
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "skin cancer",
"description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells."
},
"synonyms": [
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "CA - skin cancer",
"description": ""
},
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "malignant neoplasm of skin",
"description": ""
},
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "melanoma and Non-melanoma skin cancer",
"description": ""
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease"
]
}
],
"mutagenesis": [],
"expression_tissue": [
{
"tissue": {
"name": "Adult mammalian kidney",
"namespace": "UBERON",
"id": "0000082",
"url": "http://purl.obolibrary.org/obo/UBERON_0000082"
},
"score": "75.82",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000138109",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000138109"
}
]
},
{
"tissue": {
"name": "Oral cavity",
"namespace": "UBERON",
"id": "0000167",
"url": "http://purl.obolibrary.org/obo/UBERON_0000167"
},
"score": "68.11",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000138109",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000138109"
}
]
},
{
"tissue": {
"name": "Stomach",
"namespace": "UBERON",
"id": "0000945",
"url": "http://purl.obolibrary.org/obo/UBERON_0000945"
},
"score": "72.64",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000138109",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000138109"
}
]
},
{
"tissue": {
"name": "Uterus",
"namespace": "UBERON",
"id": "0000995",
"url": "http://purl.obolibrary.org/obo/UBERON_0000995"
},
"score": "66.15",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000138109",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000138109"
}
]
},
{
"tissue": {
"name": "Esophagus",
"namespace": "UBERON",
"id": "0001043",
"url": "http://purl.obolibrary.org/obo/UBERON_0001043"
},
"score": "55.83",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000138109",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000138109"
}
]
},
{
"tissue": {
"name": "Rectum",
"namespace": "UBERON",
"id": "0001052",
"url": "http://purl.obolibrary.org/obo/UBERON_0001052"
},
"score": "62.61",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000138109",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000138109"
}
]
},
{
"tissue": {
"name": "Colon",
"namespace": "UBERON",
"id": "0001155",
"url": "http://purl.obolibrary.org/obo/UBERON_0001155"
},
"score": "56.57",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000138109",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000138109"
}
]
},
{
"tissue": {
"name": "Urinary bladder",
"namespace": "UBERON",
"id": "0001255",
"url": "http://purl.obolibrary.org/obo/UBERON_0001255"
},
"score": "45.79",
"present": "ABSENT",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000138109",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000138109"
}
]
},
{
"tissue": {
"name": "Thyroid gland",
"namespace": "UBERON",
"id": "0002046",
"url": "http://purl.obolibrary.org/obo/UBERON_0002046"
},
"score": "40.42",
"present": "LOW",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000138109",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000138109"
}
]
},
{
"tissue": {
"name": "Lung",
"namespace": "UBERON",
"id": "0002048",
"url": "http://purl.obolibrary.org/obo/UBERON_0002048"
},
"score": "56.51",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000138109",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000138109"
}
]
},
{
"tissue": {
"name": "Liver",
"namespace": "UBERON",
"id": "0002107",
"url": "http://purl.obolibrary.org/obo/UBERON_0002107"
},
"score": "99.16",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000138109",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000138109"
}
]
},
{
"tissue": {
"name": "Prostate gland",
"namespace": "UBERON",
"id": "0002367",
"url": "http://purl.obolibrary.org/obo/UBERON_0002367"
},
"score": "42.27",
"present": "LOW",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000138109",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000138109"
}
]
},
{
"tissue": {
"name": "Thoracic mammary gland",
"namespace": "UBERON",
"id": "0005200",
"url": "http://purl.obolibrary.org/obo/UBERON_0005200"
},
"score": "42.62",
"present": "LOW",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000138109",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000138109"
}
]
}
],
"expression_disease": [
{
"significant": "Yes",
"trend": "up",
"name": "Prostate cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10283",
"evidence": [
{
"database": "BioXpress",
"id": "P11712",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11712"
}
],
"disease": [
{
"disease_id": "DOID:10283",
"recommended_name": {
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer",
"description": "A male reproductive organ cancer that is located_in the prostate."
},
"synonyms": [
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "NGP - new growth of prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "malignant tumor of the prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "tumor of the prostate",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, type 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "HPC9",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "EHBP1 familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "familial prostate cancer caused by mutation in EHBP1",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, type 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "HPC12",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, type 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "HPC5",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, type 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, susceptibility to, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "HPC3",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, type 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, susceptibility to, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "HPC4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, on chromosome 7",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "MSMB familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "familial prostate cancer caused by mutation in MSMB",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, type 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "HPC13",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, type 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "HPC8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "predisposing for prostate cancer",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, type 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "HPC6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "HPC10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate carcinoma",
"description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate carcinoma",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, somatic",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, hereditary",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "HPC7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer aggressiveness",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "RNASEL familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "familial prostate cancer caused by mutation in RNASEL",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, type 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "HPC1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "Prca1",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "HPC11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "HPC14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "HPC15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "HPCX1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer susceptibility, X-linked",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "HPCX2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MIM:611868",
"resource": "MIM",
"url": "https://www.omim.org/entry/611868",
"name": "Prostate cancer, hereditary, 12",
"description": "Prostate cancer, hereditary, 12"
},
{
"id": "MIM:611928",
"resource": "MIM",
"url": "https://www.omim.org/entry/611928",
"name": "Prostate cancer, hereditary, 13",
"description": "Prostate cancer, hereditary, 13"
},
{
"id": "MIM:176807",
"resource": "MIM",
"url": "https://www.omim.org/entry/176807",
"name": "Prostate cancer",
"description": "Prostate cancer"
},
{
"id": "MIM:601518",
"resource": "MIM",
"url": "https://www.omim.org/entry/601518",
"name": "Prostate cancer, hereditary, 1",
"description": "Prostate cancer, hereditary, 1"
},
{
"id": "MIM:611955",
"resource": "MIM",
"url": "https://www.omim.org/entry/611955",
"name": "Prostate cancer, hereditary, 11",
"description": "Prostate cancer, hereditary, 11"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Stomach cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10534",
"evidence": [
{
"database": "BioXpress",
"id": "P11712",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11712"
}
],
"disease": [
{
"disease_id": "DOID:10534",
"recommended_name": {
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "stomach cancer",
"description": "A gastrointestinal system cancer that is located_in the stomach."
},
"synonyms": [
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric cancer",
"description": ""
},
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric neoplasm",
"description": ""
},
{
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"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": "A primary or metastatic malignant neoplasm involving the stomach."
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca lesser curvature - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "cancer of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer risk after h. pylori infection",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumor",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumour",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant stomach neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "stomach cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca body - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "ca greater curvature of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, intestinal",
"description": ""
},
{
"id": "MIM:613659",
"resource": "MIM",
"url": "https://www.omim.org/entry/613659",
"name": "Gastric cancer",
"description": "Gastric cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Urinary bladder cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11054",
"evidence": [
{
"database": "BioXpress",
"id": "P11712",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11712"
}
],
"disease": [
{
"disease_id": "DOID:11054",
"recommended_name": {
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "urinary bladder cancer",
"description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder."
},
"synonyms": [
{
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "bladder cancer",
"description": ""
},
{
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": "A primary or metastatic malignant neoplasm involving the bladder."
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "bladder cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "cancer of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumour",
"description": ""
},
{
"id": "MIM:109800",
"resource": "MIM",
"url": "https://www.omim.org/entry/109800",
"name": "Bladder cancer",
"description": "Bladder cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Head and neck cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11934",
"evidence": [
{
"database": "BioXpress",
"id": "P11712",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11712"
}
],
"disease": [
{
"disease_id": "DOID:11934",
"recommended_name": {
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck cancer",
"description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
},
"synonyms": [
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck tumours",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head/neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "tumor of head and neck",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Lung cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1324",
"evidence": [
{
"database": "BioXpress",
"id": "P11712",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11712"
}
],
"disease": [
{
"disease_id": "DOID:1324",
"recommended_name": {
"id": "DOID:1324",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1324",
"name": "lung cancer",
"description": "A respiratory system cancer that is located_in the lung."
},
"synonyms": [
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "LNCR1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "LNCR3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "adenocarcinoma of lung, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "LNCR4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "LNCR5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": "A malignant neoplasm involving the lung."
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "cancer of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung neoplasm",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumor",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumour",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung neoplasm",
"description": ""
},
{
"id": "MIM:211980",
"resource": "MIM",
"url": "https://www.omim.org/entry/211980",
"name": "Lung cancer",
"description": "Lung cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Breast cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1612",
"evidence": [
{
"database": "BioXpress",
"id": "P11712",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11712"
}
],
"disease": [
{
"disease_id": "DOID:1612",
"recommended_name": {
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast cancer",
"description": "A thoracic cancer that originates in the mammary gland."
},
"synonyms": [
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant neoplasm of breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant tumor of the breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary cancer",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "primary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, lobular, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of the breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial Male",
"description": ""
},
{
"id": "MIM:114480",
"resource": "MIM",
"url": "https://www.omim.org/entry/114480",
"name": "Breast cancer",
"description": "Breast cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Thyroid cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1781",
"evidence": [
{
"database": "BioXpress",
"id": "P11712",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11712"
}
],
"disease": [
{
"disease_id": "DOID:1781",
"recommended_name": {
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid cancer",
"description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
},
"synonyms": [
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid gland cancer",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "Thyroid gland neoplasm",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant tumour of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Kidney cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:263",
"evidence": [
{
"database": "BioXpress",
"id": "P11712",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11712"
}
],
"disease": [
{
"disease_id": "DOID:263",
"recommended_name": {
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "kidney cancer",
"description": "A urinary system cancer that is located_in the kidney."
},
"synonyms": [
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant neoplasm of kidney except pelvis",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant tumour of kidney",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "renal cancer",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Liver cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:3571",
"evidence": [
{
"database": "BioXpress",
"id": "P11712",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11712"
}
],
"disease": [
{
"disease_id": "DOID:3571",
"recommended_name": {
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "liver cancer",
"description": "A hepatobiliary system cancer that is located_in the liver."
},
"synonyms": [
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Ca liver - primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Resectable malignant neoplasm of Liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant hepato-biliary neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant tumor of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "non-resectable primary hepatic malignant neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary liver cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "resectable malignant neoplasm of the liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, not specified as primary or secondary",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Uterine cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:363",
"evidence": [
{
"database": "BioXpress",
"id": "P11712",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11712"
}
],
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Esophageal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:5041",
"evidence": [
{
"database": "BioXpress",
"id": "P11712",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11712"
}
],
"disease": [
{
"disease_id": "DOID:5041",
"recommended_name": {
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophageal cancer",
"description": "A gastrointestinal system cancer that is located_in the esophagus."
},
"synonyms": [
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophagus cancer",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Distal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Proximal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of the middle Third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": "A primary or metastatic malignant neoplasm involving the esophagus."
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "oesophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of lower third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of middle third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of proximal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of upper third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of distal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of proximal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of the middle third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
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}
]
},
{
"title": "Human liver microsomal metabolism of paclitaxel and drug interactions.",
"journal": "European journal of drug metabolism and pharmacokinetics",
"date": "1998",
"authors": "Desai PB, Duan JZ, Zhu YW, Kouzi S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-211981",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211981"
}
],
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{
"type": "PubMed",
"id": "9842986",
"url": "https://glygen.org/publication/PubMed/9842986"
}
]
},
{
"title": "Analysis of cytochrome P450 metabolites of arachidonic and linoleic acids by liquid chromatography-mass spectrometry with ion trap MS.",
"journal": "Analytical biochemistry",
"date": "1998",
"authors": "Bylund J, Ericsson J, Oliw EH",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
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{
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"type": "PubMed",
"id": "9866708",
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},
{
"title": "Respective roles of human cytochrome P-4502E1, 1A2, and 3A4 in the hepatic microsomal ethanol oxidizing system.",
"journal": "Alcoholism, clinical and experimental research",
"date": "1998",
"authors": "Salmela KS, Kessova IG, Tsyrlov IB, Lieber CS",
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{
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"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211999"
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"type": "PubMed",
"id": "9884161",
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"pathway": [
{
"id": "hsa:1559",
"name": "",
"url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:1559",
"resource": "KEGG Pathway"
},
{
"id": "R-HSA-211981",
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},
{
"id": "R-HSA-211999",
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},
{
"id": "R-HSA-2142670",
"name": "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)",
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"description": "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)"
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{
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"name": "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)",
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"resource": "Reactome",
"description": "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"
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{
"id": "R-HSA-9027307",
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"description": "Biosynthesis of maresin-like SPMs"
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{
"id": "R-HSA-9749641",
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],
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{
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"protein_name": "Cytochrome P450 2C7",
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"length": 490
},
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"length": 490
},
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},
{
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{
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},
{
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},
{
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},
{
"id": "45923532",
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}
],
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},
{
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"length": 490
},
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},
{
"id": "45923523",
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},
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},
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{
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"length": 490
},
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},
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},
{
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"length": 490
},
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},
{
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"length": 490
},
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{
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}
],
"common_name": "Mouse"
},
{
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"protein_name": "Cytochrome P450 2C39",
"gene_name": "Cyp2c39",
"tax_id": 10090,
"organism": "Mus musculus",
"sequence": {
"sequence": "MDLVTFLVLTLSSLILLSLWRQSCGRGSLPPGPTPFPIIGNFLQIDIKNVSQSLTNFSKAYGPVFTLYLGSRPTVVLHGYEAVKEALIDHGEEFSDRGSIPMVEKINNGLGIVFSNGNRWKEIRRFTLTTLRNLGMGKRNIEDRVQEEAQCLVEELRKTKGSPCDPTFILSCAPCNVICSIIFQDRFDYKDKDFLMLMEKLNENVKILSSPWLQVCNNFPLLIDYCPGSHHKVLKNVKYIRSYLLEKIKEHQESLDVTNPRDFIDYYLIKQKQANHIQQAEFSLENLACTINNLFAAGTETTSTTLRYALLLLMKYPDVTAKVQEEIDHVIGRHRSPCMQDRNHMPYTDAMIHEVQRFINLVPNNIPRAVTCDIKFRNYLIPKGTTVVTSLTSVLHDSKEFPNPELFDPGHFLDANGNFKKSDHFMPFSAGKRVCAGEGLARMELFLFLTTILQNFKLKSLVHPKDIDMIPFVNGLIALPPHYQVCIIPR",
"length": 490
},
"evidence": [
{
"id": "45923522",
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"database": "MGI"
}
],
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},
{
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"protein_name": "Cytochrome P450, family 2, subfamily c, polypeptide 65",
"gene_name": "Cyp2c65",
"tax_id": 10090,
"organism": "Mus musculus",
"sequence": {
"sequence": "MVLGVFLGLLLTCLLLLSLWRQNSQRRNLPPGPTPLPIIGNILQLDLKDISKSLRNFSKVYGPVFTLYLGRNPAVVLHGYEAVKEAFTDHGEEFAGRGVFPVFDKFKKNCGVVFSSGRTWKEMRRFSLMTLRNFGMGRRSIEDRIQEEARCLVDELRKTKGEPCDPTFILGCAPCNVICSIVFQNRFDYKDQEFLTFLDILNENVEILSSPWIQICNNFPAVIDYLPGRHRKLHKNFAFAEHYFLSKVKQHQESLDINNPRDFIDCFLIKMEQEKHNPKTEFTCENLVFTASDLFAAGTETTSTTLRYSLLLLLKYPEVTAKVQEEIDCVIGRHRSPCMQDRHSMPYTDAVLHEIQRYIDLLPTSLPHAVTRDVKFREYLIPKGTTVIASLTSVLYDDKEFPNPEKFDPSHFLDERGKFKKSDYFFPFSTGKRICVGEGLARAELFLFLTTILQNFNLKSPVDLKDLDTTPVANGFASVPPKFQICFIPI",
"length": 490
},
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{
"id": "45923541",
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}
],
"common_name": "Mouse"
},
{
"uniprot_canonical_ac": "Q5GLZ0-1",
"protein_name": "Cytochrome P450 2C66",
"gene_name": "Cyp2c66",
"tax_id": 10090,
"organism": "Mus musculus",
"sequence": {
"sequence": "MVLGVFLGLLLTCLLLLSLWKQNSQRRNLPPGPTPLPIIGNILQLDLKDISKSLRNFSKVYGPVFTLYLGKKPAVVLHGYKAVKEALIDHGEEFAGRGTFPVADKFIRRCGVVFSSGRTWKEMRRFSLMTLRNFGMGKRSIEDRVQEEARCLVDELRKTKGVPCDPTFILGCAPCNVICSIVFQNRFDYKDQEFLTFIDILNENVEILSSPWIQVCNNFPAIIDYLPGRHRKLLKNFDFAKHYFLAKVIQHKESLDINNPRDFIDCFLIKMEQEKHNPKTEFTCENLIFTASDLFAAGTETTSTTLRYSLLLLLKYPEVTAKVQAEIDCVIGRHRSPCMQDRHSMPYTDAVLHEIQRYIDLLPTSLPHAVTRDVKFREYLIPKGTTVIASLTSVLYDDKEFLNPERFDPSHFLDESGKFKKSDYFFPFSTGKRICVGEGLARTELFLFLTTILQNFNLKSPVDLKDLDTTPVANGFVSVPPKFQICFISI",
"length": 490
},
"evidence": [
{
"id": "45923532",
"url": "http://www.informatics.jax.org/homology/45923532",
"database": "MGI"
}
],
"common_name": "Mouse"
},
{
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"protein_name": "Cytochrome P450 2C29",
"gene_name": "Cyp2c29",
"tax_id": 10090,
"organism": "Mus musculus",
"sequence": {
"sequence": "MDLVVFLALTLSCLILLSLWRQSSGRGKLPPGPTPLPIIGNFLQIDVKNISQSFTNFSKAYGPVFTLYLGSKPTVILHGYEAVKEALIDRGEEFAGRGSFPMAEKIIKGFGVVFSNGNRWKEMRRFTLMTLRNLGMGKRNIEDRVQEEAQCLVEELRKTKGSPCDPTFILSCAPCNVICSIIFQNRFDYKDKEFLILMDKINENVKILSSPWLQVCNSFPSLIDYCPGSHHKIVKNFNYLKSYLLEKIKEHKESLDVTNPRDFIDYYLIKQKQVNHIEQSEFSLENLASTINDLFGAGTETTSTTLRYALLLLLKYPDVTAKVQEEIDRVVGRHRSPCMQDRSHMPYTDAMIHEVQRFIDLLPTSLPHAVTCDIKFRKYLIPKGTTVITSLSSVLHDSKEFPNPEMFDPGHFLNGNGNFKKSDYFMPFSTGKRICAGEGLARMELFLILTTILQNFKLKSLVHPKEIDITPVMNGFASLPPPYQLCFIPL",
"length": 490
},
"evidence": [
{
"id": "45923523",
"url": "http://www.informatics.jax.org/homology/45923523",
"database": "MGI"
}
],
"common_name": "Mouse"
},
{
"uniprot_canonical_ac": "Q91X77-1",
"protein_name": "Cytochrome P450 2C50",
"gene_name": "Cyp2c50",
"tax_id": 10090,
"organism": "Mus musculus",
"sequence": {
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"length": 490
},
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{
"id": "45923539",
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"database": "MGI"
}
],
"common_name": "Mouse"
}
],
"go_annotation": {
"categories": [
{
"name": "Molecular Function",
"total": 15,
"go_terms": [
{
"name": "iron ion binding",
"id": "GO:0005506",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "heme binding",
"id": "GO:0020037",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "monooxygenase activity",
"id": "GO:0004497",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004497",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen",
"id": "GO:0016705",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016705",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "arachidonic acid 14,15-epoxygenase activity",
"id": "GO:0008404",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008404",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "arachidonic acid 11,12-epoxygenase activity",
"id": "GO:0008405",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008405",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "(S)-limonene 6-monooxygenase activity",
"id": "GO:0018675",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018675",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "(S)-limonene 7-monooxygenase activity",
"id": "GO:0018676",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018676",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "(R)-limonene 6-monooxygenase activity",
"id": "GO:0052741",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052741",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "aromatase activity",
"id": "GO:0070330",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070330",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "oxidoreductase activity",
"id": "GO:0016491",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen",
"id": "GO:0016712",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016712",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "arachidonic acid epoxygenase activity",
"id": "GO:0008392",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008392",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "steroid hydroxylase activity",
"id": "GO:0008395",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008395",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "caffeine oxidase activity",
"id": "GO:0034875",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034875",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
}
]
},
{
"name": "Biological Process",
"total": 14,
"go_terms": [
{
"name": "estrogen metabolic process",
"id": "GO:0008210",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008210",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "monoterpenoid metabolic process",
"id": "GO:0016098",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016098",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "omega-hydroxylase P450 pathway",
"id": "GO:0097267",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097267",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "icosanoid biosynthetic process",
"id": "GO:0046456",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046456",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "cholesterol metabolic process",
"id": "GO:0008203",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008203",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "xenobiotic metabolic process",
"id": "GO:0006805",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006805",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "xenobiotic catabolic process",
"id": "GO:0042178",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042178",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "oxidative demethylation",
"id": "GO:0070989",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070989",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "steroid metabolic process",
"id": "GO:0008202",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008202",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "long-chain fatty acid biosynthetic process",
"id": "GO:0042759",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042759",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "epoxygenase P450 pathway",
"id": "GO:0019373",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019373",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "urea metabolic process",
"id": "GO:0019627",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019627",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "amide metabolic process",
"id": "GO:0043603",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043603",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "monocarboxylic acid metabolic process",
"id": "GO:0032787",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032787",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
}
]
},
{
"name": "Cellular Component",
"total": 4,
"go_terms": [
{
"name": "cytoplasm",
"id": "GO:0005737",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "plasma membrane",
"id": "GO:0005886",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "intracellular membrane-bounded organelle",
"id": "GO:0043231",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
},
{
"name": "endoplasmic reticulum membrane",
"id": "GO:0005789",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789",
"evidence": [
{
"database": "UniProtKB",
"id": "P11712",
"url": "https://www.uniprot.org/uniprot/P11712"
}
],
"pmid": ""
}
]
}
]
},
"pro_annotation": [],
"site_annotation": [
{
"start_pos": 218,
"end_pos": 220,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 334,
"end_pos": 336,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 56,
"end_pos": 58,
"annotation": "n_glycosylation_sequon"
}
],
"ptm_annotation": [],
"interactions": [],
"reactions": [
{
"id": "17149",
"name": "",
"equation": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11711-1",
"P05182-1",
"A0A8I6A0P6-1",
"P10633-1",
"P51538-1",
"P00176-1",
"P05178-1",
"P10610-1",
"P13107-1",
"P20812-1",
"P33272-1",
"P51870-1",
"P00185-1",
"Q64581-1",
"P05179-1",
"P51871-1",
"P04167-1",
"P04800-1",
"P05183-1",
"P10634-1",
"P11510-1",
"P12938-1",
"P12939-1",
"P15129-1",
"P15149-1",
"P20814-1",
"P33273-1",
"P51590-1",
"Q64583-1",
"Q64680-1",
"P04799-1",
"Q64678-1",
"P08683-1",
"P24464-1",
"D4A820-1",
"A0A0G2K5K4-1",
"F1LT33-1",
"G3V9D2-1",
"Q9QXF7-1",
"A0A8I5ZZ08-1",
"P05181-1",
"A0A087X1C5-1",
"P08684-1",
"P20853-1",
"P04798-1",
"P05177-1",
"P33261-1",
"Q86W10-1",
"Q16678-1",
"P98187-1",
"P10632-1",
"P24462-1",
"Q9HB55-1",
"P13584-1",
"Q16696-1",
"Q9HCS2-1",
"P33260-1",
"Q02928-1",
"Q08477-1",
"Q9HBI6-1",
"P78329-1",
"P11712-1",
"P24903-1",
"P20815-1",
"Q6V0L0-1",
"P20852-1",
"O09158-1",
"O55071-1",
"Q64459-1",
"Q64481-1",
"O54749-1",
"P15392-1",
"Q8CIM7-1",
"P56654-1",
"P56655-1",
"P56656-1",
"P12791-1",
"P56593-1",
"O54750-1",
"Q91WL5-1",
"Q91X77-1",
"Q64458-1",
"P00186-1",
"P00184-1",
"Q6XVG2-1",
"Q9D816-1",
"P11714-1",
"P12790-1",
"P24457-1",
"Q9JMA7-1",
"P24456-1",
"Q64462-1",
"Q64464-1",
"Q05421-1",
"Q64429-1",
"D3YYZ0-1",
"D3Z2W7-1",
"B2RXZ2-1",
"Q9WV19-1",
"Q9DBX6-1",
"E9Q593-1",
"A2A974-1",
"A6H6J2-1",
"Q9EQW4-1",
"B2RXA7-1"
],
"evidence": [
{
"id": "17149",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/17149"
}
]
},
{
"id": "17945",
"name": "",
"equation": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P33261-1",
"P11712-1"
],
"evidence": [
{
"id": "17945",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/17945"
}
]
},
{
"id": "18957",
"name": "",
"equation": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P33261-1",
"P11712-1"
],
"evidence": [
{
"id": "18957",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/18957"
}
]
},
{
"id": "23432",
"name": "",
"equation": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P33261-1",
"P11712-1"
],
"evidence": [
{
"id": "23432",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/23432"
}
]
},
{
"id": "39759",
"name": "",
"equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P04799-1",
"Q4V8D1-1",
"Q9QXF7-1",
"P04798-1",
"P05177-1",
"P33261-1",
"P11712-1",
"Q7Z449-1",
"P00186-1",
"P00184-1",
"Q91WL5-1",
"Q9CX98-1",
"A2A974-1"
],
"evidence": [
{
"id": "39759",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/39759"
}
]
},
{
"id": "39779",
"name": "",
"equation": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P04799-1",
"P08683-1",
"P24470-1",
"P08684-1",
"P51589-1",
"P04798-1",
"P05177-1",
"P33261-1",
"P10632-1",
"P11712-1",
"P00186-1",
"P00184-1",
"Q91WL5-1",
"E9Q5K4-1",
"A2A974-1"
],
"evidence": [
{
"id": "39779",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/39779"
}
]
},
{
"id": "47208",
"name": "",
"equation": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P04799-1",
"Q64678-1",
"P08684-1",
"P04798-1",
"P05177-1",
"Q16678-1",
"P11511-1",
"P20813-1",
"P24462-1",
"P11712-1",
"P20815-1",
"P28649-1",
"P00186-1",
"P00184-1",
"Q64429-1"
],
"evidence": [
{
"id": "47208",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/47208"
}
]
},
{
"id": "47212",
"name": "",
"equation": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P04799-1",
"Q64678-1",
"P08684-1",
"P04798-1",
"P05177-1",
"Q16678-1",
"P11712-1",
"P20813-1",
"P24462-1",
"P20815-1",
"P00186-1",
"P00184-1",
"Q64429-1"
],
"evidence": [
{
"id": "47212",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/47212"
}
]
},
{
"id": "49856",
"name": "",
"equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P04799-1",
"Q64678-1",
"P08683-1",
"P24470-1",
"P10635-1",
"P08684-1",
"P51589-1",
"P04798-1",
"P05177-1",
"P10632-1",
"P11712-1",
"Q86W10-1",
"P00186-1",
"P00184-1",
"P56657-1"
],
"evidence": [
{
"id": "49856",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/49856"
}
]
},
{
"id": "49860",
"name": "",
"equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P04799-1",
"Q64678-1",
"P08683-1",
"P24470-1",
"P08684-1",
"P51589-1",
"P04798-1",
"P05177-1",
"P33261-1",
"Q16678-1",
"P10632-1",
"P11712-1",
"P00186-1",
"P00184-1",
"Q64429-1",
"P56657-1"
],
"evidence": [
{
"id": "49860",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/49860"
}
]
},
{
"id": "49876",
"name": "",
"equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"Q64678-1",
"P08683-1",
"P24470-1",
"P51589-1",
"P33261-1",
"Q16678-1",
"P10632-1",
"P11712-1",
"Q64429-1"
],
"evidence": [
{
"id": "49876",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/49876"
}
]
},
{
"id": "49880",
"name": "",
"equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"Q64678-1",
"P08683-1",
"P24470-1",
"P10635-1",
"P51589-1",
"P04798-1",
"P33261-1",
"Q16678-1",
"P10632-1",
"P11712-1",
"P00184-1",
"Q64429-1",
"E9Q5K4-1"
],
"evidence": [
{
"id": "49880",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/49880"
}
]
},
{
"id": "49884",
"name": "",
"equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"Q64678-1",
"P08683-1",
"P24470-1",
"P10635-1",
"P51589-1",
"P04798-1",
"P33261-1",
"Q16678-1",
"P11712-1",
"P00184-1",
"Q64429-1",
"E9Q5K4-1"
],
"evidence": [
{
"id": "49884",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/49884"
}
]
},
{
"id": "49928",
"name": "",
"equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P08683-1",
"P51589-1",
"P11712-1"
],
"evidence": [
{
"id": "49928",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/49928"
}
]
},
{
"id": "50256",
"name": "",
"equation": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P04799-1",
"P10635-1",
"P08684-1",
"P05177-1",
"P11712-1",
"P00186-1"
],
"evidence": [
{
"id": "50256",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/50256"
}
]
},
{
"id": "51472",
"name": "",
"equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11712-1",
"P56656-1",
"Q64458-1",
"E9Q5K4-1"
],
"evidence": [
{
"id": "51472",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/51472"
}
]
},
{
"id": "51480",
"name": "",
"equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11712-1",
"P56655-1",
"P56656-1"
],
"evidence": [
{
"id": "51480",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/51480"
}
]
},
{
"id": "52168",
"name": "",
"equation": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P08683-1",
"P24470-1",
"P11712-1",
"E9Q5K4-1"
],
"evidence": [
{
"id": "52168",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/52168"
}
]
},
{
"id": "52172",
"name": "",
"equation": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P08683-1",
"P24470-1",
"P10632-1",
"P11712-1",
"E9Q5K4-1"
],
"evidence": [
{
"id": "52172",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/52172"
}
]
},
{
"id": "52176",
"name": "",
"equation": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P08683-1",
"P24470-1",
"P10632-1",
"P11712-1",
"E9Q5K4-1"
],
"evidence": [
{
"id": "52176",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/52176"
}
]
},
{
"id": "52292",
"name": "",
"equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P04799-1",
"P08684-1",
"P05177-1",
"P11712-1",
"P00186-1"
],
"evidence": [
{
"id": "52292",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/52292"
}
]
},
{
"id": "52296",
"name": "",
"equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P08684-1",
"P11712-1"
],
"evidence": [
{
"id": "52296",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/52296"
}
]
},
{
"id": "52300",
"name": "",
"equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11712-1"
],
"evidence": [
{
"id": "52300",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/52300"
}
]
},
{
"id": "52492",
"name": "",
"equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11712-1"
],
"evidence": [
{
"id": "52492",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/52492"
}
]
},
{
"id": "52496",
"name": "",
"equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11712-1"
],
"evidence": [
{
"id": "52496",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/52496"
}
]
},
{
"id": "52500",
"name": "",
"equation": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = (13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11712-1"
],
"evidence": [
{
"id": "52500",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/52500"
}
]
},
{
"id": "52504",
"name": "",
"equation": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = (9R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11712-1"
],
"evidence": [
{
"id": "52504",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/52504"
}
]
},
{
"id": "52508",
"name": "",
"equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11712-1"
],
"evidence": [
{
"id": "52508",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/52508"
}
]
},
{
"id": "R-HSA-143468",
"name": "MEOS oxidizes ethanol to acetaldehyde",
"equation": "",
"summary": "The MEOS (microsomal ethanol oxidizing system) is an accessory pathway in the liver which increases in activity on chronic alcohol induction. The MEOS utilizes a cytochrome P450 which has since been deciphered to be CYP2E1, an ethanol-inducible form of P450. CYP2E1 also increases acetaldehyde formation and free radicals which can initiate lipid peroxidation. CYP2E1 can also activate many over-the-counter medicines and solvents to toxic metabolites and deplete retinoids resulting in their depletion and deletrious effects. This is because, being a cytochrome P450 and using NADPH and oxygen, it has the ability to biotransform drugs when it has been induced by ethanol.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-113748"
],
"output_participant_list": [
"R-ALL-113745"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P11509-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-143468",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-143468"
}
]
},
{
"id": "R-HSA-211881",
"name": "Coumarin is 7-hydroxylated by CYP2A13",
"equation": "",
"summary": "CYP2A13 can also 7-hydroxylate coumarin. It shares a 93.5% identity with CYP2A6 in the amino acid sequence but it is only about one-tenth as active as CYP2A6 in catalyzing coumarin 7-hydroxylation.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane, smooth endoplasmic reticulum",
"input_participant_list": [
"R-ALL-76328"
],
"output_participant_list": [
"R-ALL-76452"
],
"enzyme_list": [
"P05181-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P51589-1",
"P11509-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-211881",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211881"
}
]
},
{
"id": "R-HSA-211910",
"name": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation",
"equation": "",
"summary": "Paclitaxel (Taxol) is a naturally occurring member of the taxane family of antitumor drugs. It acts by stabilizing microtubules. Paclitaxel is inactivated in human liver by CYP2C8, which catalyzes 6alpha-hydroxylation of paclitaxel.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-211906"
],
"output_participant_list": [
"R-ALL-211894"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"P33260-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-211910",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211910"
}
]
},
{
"id": "R-HSA-211929",
"name": "CYP2C19 5-hydroxylates omeprazole",
"equation": "",
"summary": "Omeprazole is a potent long-acting inhibitor of gastric acid secretion by irreversible binding to the proton pump (H+,K+) ATPase in the gastric parietal cell. CYP2C19 is the major P450 which involved in 5-hydroxylation of omeprazole.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-211892"
],
"output_participant_list": [
"R-ALL-211944"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"P33260-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-211929",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211929"
}
]
},
{
"id": "R-HSA-211966",
"name": "CYP2D6 4-hydroxylates debrisoquine",
"equation": "",
"summary": "CYP2D6 (debrisoquine 4-hydroxylase) has a wide substrate specificity and is an important cytochrme P450 in drug metabolism. It has extensive genetic polymorphism (called the debrisoquine/sparteine oxidation polymorphism) that influences its expression and function.The polymorphism is responsible for populations being poor metabolizers (PM) or extensive metabolizers (EM, normal). Approximately 10% of Caucasians and less than 1% of Asians lack the CYP2D6 protein because of two null alleles which do not encode the functional product. Further polymorphisms discovered recently have identified ultrarapid metabolizers (PM) (alleles with multiple gene copies) and intermediate metabolizers (IM) (deficiency in their metabolism capacity) (Zanger UM et al, 2004).",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-211993"
],
"output_participant_list": [
"R-ALL-211952"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P33261-1",
"P51589-1",
"Q8TAV3-1",
"P10632-1",
"P11712-1"
],
"evidence": [
{
"id": "R-HSA-211966",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211966"
}
]
},
{
"id": "R-HSA-211988",
"name": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation",
"equation": "",
"summary": "Tolbutamide is an oral hypoglycemic agent whose action is terminated by hydroxylation of the tolylsulfonyl methyl moiety. The reaction is catalyzed by CYP2C9.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-9838902"
],
"output_participant_list": [
"R-ALL-211937"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"P33260-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-211988",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211988"
}
]
},
{
"id": "R-HSA-211991",
"name": "Cyclophosphamide is 4-hydroxylated by CYP2B6",
"equation": "",
"summary": "Cyclophosphamide (CPA) is an alkylating agent used in cancer chemotherapy and an immunosuppressant. CYP2B6 converts CPA to the active metabolite 4-hydroxy-CPA.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-211977"
],
"output_participant_list": [
"R-ALL-211967"
],
"enzyme_list": [
"P05181-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P51589-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-211991",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211991"
}
]
},
{
"id": "R-HSA-212004",
"name": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation",
"equation": "",
"summary": "Phenytoin is a widely used anti-epileptic drug which can be hydroxylated by several P450s including CYP2C18 to its major metabolite, (5-(4-hydroxyphenyl)-phenylhydantoin (HPPH).",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-211939"
],
"output_participant_list": [
"R-ALL-211927"
],
"enzyme_list": [
"P33261-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P33260-1"
],
"evidence": [
{
"id": "R-HSA-212004",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-212004"
}
]
},
{
"id": "R-HSA-212005",
"name": "CYP2F1 dehydrogenates 3-methylindole",
"equation": "",
"summary": "3-methylindole (3MI) is a fermentation product of tryptophan. It is usually formed in the rumen of goats and cattle and in the large intestine of humans. CYP2F1 shows the highest activity towards the dehydrogenation of 3MI to form a methylene imine-reactive intermediate.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-213162"
],
"output_participant_list": [
"R-ALL-213163"
],
"enzyme_list": [
"P05181-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P51589-1",
"P11509-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-212005",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-212005"
}
]
},
{
"id": "R-HSA-2161814",
"name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)",
"equation": "",
"summary": "Several cytochrome P450s (CYPs) convert arachidonic acid to 19-hydroxyeicosatetraenoic acid (19-HETE). The CYPs and their references are as follows: CYP2C8 (Bylund et al. 1998); CYP2C9 (Bylund et al. 1998); CYP2C19 (Bylund et al. 1998); CYP4A11 (Gainer et al. 2005); CYP2U1 (Chuang et al. 2004); CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004).",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [],
"output_participant_list": [
"R-ALL-2142836"
],
"enzyme_list": [
"P33261-1",
"Q16678-1",
"Q7Z449-1",
"P04798-1",
"P10632-1",
"P11712-1",
"Q02928-1",
"P05177-1"
],
"evidence": [
{
"id": "R-HSA-2161814",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2161814"
}
]
},
{
"id": "R-HSA-2161899",
"name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)",
"equation": "",
"summary": "Several cytochrome P450s (CYPs) convert arachidonic acid to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids (8,9-, 11,12-, 14,15-EETs). The CYPs and their references are as follows: CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004); CYP2C8, CYP2C9 (Rifkind et al. 1995); CYP2C19 (Bylund et al. 1998, Rifkind et al. 1995); CYP2J2 (Wu et al. 1996).",
"cellular_location": "cytosol, endoplasmic reticulum membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P33261-1",
"P51589-1",
"Q16678-1",
"P04798-1",
"P10632-1",
"P11712-1",
"P05177-1"
],
"evidence": [
{
"id": "R-HSA-2161899",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2161899"
}
]
},
{
"id": "R-HSA-76354",
"name": "Vinyl chloride is oxidized to 2-Chloroethylene oxide",
"equation": "",
"summary": "CYP2E1 can catalyze the oxidation of the vinyl halide vinyl chloride to the epoxide 2-chloroethylene oxide. The epoxide is very unstable and rearranges quickly to 2-chloroacetaldehyde. Both these products can interact with DNA and proteins.",
"cellular_location": "smooth endoplasmic reticulum",
"input_participant_list": [
"R-ALL-39417"
],
"output_participant_list": [
"R-ALL-156524"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P11509-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-76354",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76354"
}
]
},
{
"id": "R-HSA-76397",
"name": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)",
"equation": "",
"summary": "N-acetyl-p-benzoquinone imine (NAPQI) is the reactive intermediate of the analgesic and antipyretic, acetaminophen (INN, paracetamol). At usual doses, NAPQI is quickly detoxified by conjugation but in overdose situations, NAPQI is extremely toxic to liver tissue.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-113555",
"R-ALL-113564",
"R-ALL-39427"
],
"output_participant_list": [
"R-ALL-76396"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P11509-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-76397",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76397"
}
]
},
{
"id": "R-HSA-76416",
"name": "Benzene is hydroxylated to phenol",
"equation": "",
"summary": "Benzene is an occupational and environmental toxicant and is implicated in myelogenous leukemia. For toxicity to occur, benzene is oxidised to phenol and subsequently to catechol and hydroquinone. CYP2E1 is the enzyme responsible for oxidation of benzene to phenol.",
"cellular_location": "smooth endoplasmic reticulum",
"input_participant_list": [
"R-ALL-31711"
],
"output_participant_list": [
"R-ALL-29630"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P11509-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-76416",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76416"
}
]
},
{
"id": "R-HSA-76434",
"name": "Dehalogenation of carbon tetrachloride to form a free radical",
"equation": "",
"summary": "Carbon tetrachloride (CCl4) has been widely used as a dry-cleaning agent, in fire extinguishers and in the manufacture of other halogenated hydrocarbons. At toxic doses, CCl4 exposure can damage the liver and kidneys. This toxicity results from CYP2E1-dependant reduction of CCl4 to the reactive trichloromethyl radical (CCl3.).",
"cellular_location": "smooth endoplasmic reticulum",
"input_participant_list": [
"R-ALL-40887"
],
"output_participant_list": [
"R-ALL-29572",
"R-ALL-76433"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P11509-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-76434",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76434"
}
]
},
{
"id": "R-HSA-76456",
"name": "O-atom dealkylation of dextromethorphan",
"equation": "",
"summary": "At the beginning of this reaction, 1 molecule of 'H+', 1 molecule of 'Dextromethorphan', 1 molecule of 'Oxygen', and 1 molecule of 'NADPH' are present. At the end of this reaction, 1 molecule of 'NADP+', 1 molecule of 'Dextrorphan', 1 molecule of 'Formaldehyde', and 1 molecule of 'H2O' are present.
This reaction takes place in the 'smooth endoplasmic reticulum' and is mediated by the 'oxygen binding activity' of 'Cytochrome P450 2D6 '.
",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane, smooth endoplasmic reticulum",
"input_participant_list": [
"R-ALL-39703"
],
"output_participant_list": [
"R-ALL-76455"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P33261-1",
"P51589-1",
"Q8TAV3-1",
"P10632-1",
"P11712-1"
],
"evidence": [
{
"id": "R-HSA-76456",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76456"
}
]
},
{
"id": "R-HSA-76475",
"name": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide",
"equation": "",
"summary": "The volatile anesthetic halothane can undergo CYP2E1-catalyzed oxidation to form a reactive intermediate which can acetylate liver proteins. These proteins can then stimulate an immune reaction that mediates severe hepatic necrosis (\\halothane hepatitis\\).",
"cellular_location": "smooth endoplasmic reticulum",
"input_participant_list": [
"R-ALL-40795"
],
"output_participant_list": [
"R-ALL-76473",
"R-ALL-76474"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P11509-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-76475",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76475"
}
]
},
{
"id": "R-HSA-9027043",
"name": "CYPs hydroxylate DHA to 14(R)-HDHA",
"equation": "",
"summary": "Using human leukocytes and platelets, Hong et al. found that incubating docosahexaenoic acid (DHA) with a mixture of human cytochrome P450 enzymes (CYP1A2, 2C8, 2C9, 2D6, 2E1 and 3A4) formed 14(R)-hydroxy-docsosahexaenoic acid (14(R)-HDHA), the precursor to maresin-like mediator 2 (MaR-L2) (Hong et al. 2014). There is no data to indicate which one or ones of these CYPs mediate this event under physiological conditions. CYP inhibition diminishes the formation of 14(R)-HDHA, confirming CYP determines 14(R)-hydroxylation (Hong et al. 2014). The CYP mixture also formed 22-hydroxy-docosahexaenoic acid (22-HDHA) by \u03c9-oxidation (not shown here). Although the CYP mixture also catalysed the formation of 14(S)-HDHA, the amount formed is minor compared to that formed by 12-lipoxygenase (Hong et al. 2014).",
"cellular_location": "cytosol, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-9024011"
],
"output_participant_list": [],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P10632-1",
"P11712-1",
"P05177-1",
"P08684-1"
],
"evidence": [
{
"id": "R-HSA-9027043",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9027043"
}
]
},
{
"id": "R-HSA-9749986",
"name": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA",
"equation": "",
"summary": "2,3-Dihydroxybenzoate (2,3-DHBA) is a minor oxidation product of salicylate (ST). The reaction is catalyzed by several CYP2 and CYP3 cytochromes in the ER of hepatocytes (Grootveld & Halliwell, 1988; Bojic et al, 2015)",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [],
"output_participant_list": [
"R-ALL-9750011"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P33261-1",
"P10632-1",
"P11712-1",
"P08684-1"
],
"evidence": [
{
"id": "R-HSA-9749986",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9749986"
}
]
},
{
"id": "R-HSA-9750016",
"name": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA",
"equation": "",
"summary": "2,5-Dihydroxybenzoate (gentisic acid, 2,5-DHBA) is a minor oxidation product of salicylate (ST). The reaction is catalyzed by several CYP2 and CYP3 cytochromes in the ER of hepatocytes (Grootveld & Halliwell, 1988; Bojic et al, 2015).",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [],
"output_participant_list": [
"R-ALL-9750014"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P33261-1",
"P10632-1",
"P11712-1",
"P08684-1"
],
"evidence": [
{
"id": "R-HSA-9750016",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9750016"
}
]
}
],
"reaction_participants": [
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"participant_name": "H2 [endoplasmic reticulum lumen]",
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]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P04167",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04167"
}
]
}
]
},
{
"uniprot_ac": "P04798",
"gene_name": "CYP1A1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P04798",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04798"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "P04798",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04798"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P04798",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04798"
}
]
}
]
},
{
"uniprot_ac": "P04799",
"gene_name": "Cyp1a2",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P04799",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04799"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P04799",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04799"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "P04799",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04799"
}
]
}
]
},
{
"uniprot_ac": "P04800",
"gene_name": "Cyp3a1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P04800",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04800"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P04800",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04800"
}
]
},
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P04800",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04800"
}
]
}
]
},
{
"uniprot_ac": "P05177",
"gene_name": "CYP1A2",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P05177",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05177"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "P05177",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05177"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P05177",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05177"
}
]
}
]
},
{
"uniprot_ac": "P05178",
"gene_name": "Cyp2c6",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P05178",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05178"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P05178",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05178"
}
]
}
]
},
{
"uniprot_ac": "P05179",
"gene_name": "Cyp2c7",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P05179",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05179"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P05179",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05179"
}
]
}
]
},
{
"uniprot_ac": "P05181",
"gene_name": "CYP2E1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P05181",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05181"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P05181",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05181"
}
]
},
{
"ec_number": "1.14.13.n7",
"activity": "4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+).",
"evidence": [
{
"id": "P05181",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05181"
}
]
},
{
"ec_number": "1.14.13.n7",
"activity": "",
"evidence": [
{
"id": "P05181",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05181"
}
]
}
]
},
{
"uniprot_ac": "P05182",
"gene_name": "Cyp2e1",
"activity": [
{
"ec_number": "1.14.13.n7",
"activity": "4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+).",
"evidence": [
{
"id": "P05182",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05182"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P05182",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05182"
}
]
},
{
"ec_number": "1.14.13.n7",
"activity": "",
"evidence": [
{
"id": "P05182",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05182"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P05182",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05182"
}
]
}
]
},
{
"uniprot_ac": "P05183",
"gene_name": "Cyp3a2",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P05183",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05183"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P05183",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05183"
}
]
}
]
},
{
"uniprot_ac": "P08683",
"gene_name": "Cyp2c11",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P08683",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08683"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P08683",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08683"
}
]
}
]
},
{
"uniprot_ac": "P08684",
"gene_name": "CYP3A4",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P08684",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08684"
}
]
},
{
"ec_number": "1.14.14.55",
"activity": "O2 + quinine + reduced [NADPH--hemoprotein reductase] = 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P08684",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08684"
}
]
},
{
"ec_number": "1.14.14.56",
"activity": "1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] = 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P08684",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08684"
}
]
},
{
"ec_number": "1.14.14.73",
"activity": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P08684",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08684"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P08684",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08684"
}
]
},
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P08684",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08684"
}
]
}
]
},
{
"uniprot_ac": "P10610",
"gene_name": "Cyp2g1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P10610",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10610"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P10610",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10610"
}
]
}
]
},
{
"uniprot_ac": "P10632",
"gene_name": "CYP2C8",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P10632",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10632"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P10632",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10632"
}
]
}
]
},
{
"uniprot_ac": "P10633",
"gene_name": "Cyp2d1",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P10633",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10633"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P10633",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10633"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P10633",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10633"
}
]
}
]
},
{
"uniprot_ac": "P10634",
"gene_name": "Cyp2d26",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P10634",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10634"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P10634",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10634"
}
]
}
]
},
{
"uniprot_ac": "P10635",
"gene_name": "CYP2D6",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P10635",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10635"
}
]
}
]
},
{
"uniprot_ac": "P11509",
"gene_name": "CYP2A6",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P11509",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11509"
}
]
}
]
},
{
"uniprot_ac": "P11510",
"gene_name": "Cyp2c12",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P11510",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11510"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P11510",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11510"
}
]
}
]
},
{
"uniprot_ac": "P11511",
"gene_name": "CYP19A1",
"activity": [
{
"ec_number": "1.14.14.14",
"activity": "androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P11511",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11511"
}
]
},
{
"ec_number": "1.14.14.14",
"activity": "",
"evidence": [
{
"id": "P11511",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11511"
}
]
}
]
},
{
"uniprot_ac": "P11711",
"gene_name": "Cyp2a1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P11711",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11711"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P11711",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11711"
}
]
}
]
},
{
"uniprot_ac": "P11712",
"gene_name": "CYP2C9",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P11712",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11712"
}
]
},
{
"ec_number": "1.14.14.51",
"activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P11712",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11712"
}
]
},
{
"ec_number": "1.14.14.52",
"activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P11712",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11712"
}
]
},
{
"ec_number": "1.14.14.53",
"activity": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P11712",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11712"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P11712",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11712"
}
]
}
]
},
{
"uniprot_ac": "P11714",
"gene_name": "Cyp2d9",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P11714",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11714"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P11714",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11714"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P11714",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11714"
}
]
}
]
},
{
"uniprot_ac": "P12790",
"gene_name": "Cyp2b9",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P12790",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12790"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P12790",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12790"
}
]
}
]
},
{
"uniprot_ac": "P12791",
"gene_name": "Cyp2b10",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P12791",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12791"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P12791",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12791"
}
]
}
]
},
{
"uniprot_ac": "P12938",
"gene_name": "Cyp2d3",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
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}
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{
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]
}
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{
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}
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{
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},
{
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}
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}
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},
{
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}
]
}
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},
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}
]
},
{
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}
]
}
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},
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}
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},
{
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}
]
}
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},
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}
]
}
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},
{
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]
}
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{
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}
]
}
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}
]
},
{
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}
]
}
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},
{
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}
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}
]
},
{
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},
{
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}
]
}
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},
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},
{
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}
]
}
]
},
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{
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}
]
},
{
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}
]
}
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},
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"ec_number": "1.14.14.1",
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},
{
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}
]
}
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},
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{
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"id": "P24470",
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}
]
}
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{
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{
"ec_number": "1.14.14.1",
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"id": "P24903",
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}
]
},
{
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"id": "P24903",
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}
]
}
]
},
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"ec_number": "1.14.14.14",
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{
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{
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"id": "P28649",
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]
}
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{
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}
]
},
{
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"id": "P33260",
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}
]
}
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{
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}
]
},
{
"ec_number": "1.14.14.51",
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{
"id": "P33261",
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]
},
{
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{
"id": "P33261",
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]
},
{
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{
"id": "P33261",
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}
]
},
{
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{
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]
},
{
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"id": "P33261",
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}
]
}
]
},
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{
"id": "P33272",
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}
]
},
{
"ec_number": "1.14.14.1",
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"id": "P33272",
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}
]
}
]
},
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"ec_number": "1.14.14.1",
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{
"id": "P33273",
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]
},
{
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"id": "P33273",
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}
]
}
]
},
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"ec_number": "1.14.14.-",
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]
},
{
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{
"id": "P51538",
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}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "P51538",
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]
}
]
},
{
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{
"ec_number": "1.14.14.-",
"activity": "",
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{
"id": "P51589",
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}
]
},
{
"ec_number": "5.4.4.7",
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{
"id": "P51589",
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}
]
},
{
"ec_number": "1.14.14.73",
"activity": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "P51589",
"database": "UniProtKB",
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}
]
},
{
"ec_number": "1.14.14.74",
"activity": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "P51589",
"database": "UniProtKB",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "P51590",
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}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "P51590",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
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{
"id": "P51870",
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}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "P51870",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "P51871",
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}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P51871",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51871"
}
]
}
]
},
{
"uniprot_ac": "P56593",
"gene_name": "Cyp2a12",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P56593",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56593"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P56593",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56593"
}
]
}
]
},
{
"uniprot_ac": "P56654",
"gene_name": "Cyp2c37",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P56654",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56654"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P56654",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56654"
}
]
}
]
},
{
"uniprot_ac": "P56655",
"gene_name": "Cyp2c38",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P56655",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56655"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P56655",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56655"
}
]
}
]
},
{
"uniprot_ac": "P56656",
"gene_name": "Cyp2c39",
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "P56656",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56656"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P56656",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56656"
}
]
}
]
},
{
"uniprot_ac": "P56657",
"gene_name": "Cyp2c40",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P56657",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56657"
}
]
}
]
},
{
"uniprot_ac": "P78329",
"gene_name": "CYP4F2",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P78329",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78329"
}
]
},
{
"ec_number": "1.14.14.78",
"activity": "O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P78329",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78329"
}
]
},
{
"ec_number": "1.14.14.79",
"activity": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P78329",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78329"
}
]
},
{
"ec_number": "1.14.14.94",
"activity": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P78329",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78329"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P78329",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78329"
}
]
}
]
},
{
"uniprot_ac": "P98187",
"gene_name": "CYP4F8",
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P98187",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P98187"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P98187",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P98187"
}
]
}
]
},
{
"uniprot_ac": "Q02928",
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q02928",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02928"
}
]
},
{
"ec_number": "1.14.14.80",
"activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q02928",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02928"
}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "Q02928",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02928"
}
]
}
]
},
{
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{
"ec_number": "1.14.13.n7",
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{
"id": "Q05421",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05421"
}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "Q05421",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05421"
}
]
},
{
"ec_number": "1.14.14.1",
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"evidence": [
{
"id": "Q05421",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05421"
}
]
},
{
"ec_number": "1.14.13.n7",
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{
"id": "Q05421",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05421"
}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q08477",
"database": "UniProtKB",
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}
]
},
{
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{
"id": "Q08477",
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}
]
},
{
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{
"id": "Q08477",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q08477"
}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "Q08477",
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"url": "https://www.uniprot.org/uniprot/Q08477"
}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
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{
"id": "Q16678",
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}
]
},
{
"ec_number": "4.2.1.152",
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{
"id": "Q16678",
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}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "Q16678",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q16696",
"database": "UniProtKB",
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}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "Q16696",
"database": "UniProtKB",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.80",
"activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q4V8D1",
"database": "UniProtKB",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q64429",
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}
]
},
{
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{
"id": "Q64429",
"database": "UniProtKB",
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}
]
},
{
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{
"id": "Q64429",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q64458",
"database": "UniProtKB",
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}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "Q64458",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q64459",
"database": "UniProtKB",
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}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "Q64459",
"database": "UniProtKB",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q64462",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64462"
}
]
},
{
"ec_number": "1.14.14.1",
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"evidence": [
{
"id": "Q64462",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64462"
}
]
}
]
},
{
"uniprot_ac": "Q64464",
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q64464",
"database": "UniProtKB",
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}
]
},
{
"ec_number": "1.14.14.1",
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"evidence": [
{
"id": "Q64464",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64464"
}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q64481",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64481"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q64481",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64481"
}
]
}
]
},
{
"uniprot_ac": "Q64581",
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{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "Q64581",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64581"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q64581",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64581"
}
]
},
{
"ec_number": "1.14.14.1",
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"evidence": [
{
"id": "Q64581",
"database": "UniProtKB",
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}
]
}
]
},
{
"uniprot_ac": "Q64583",
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q64583",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64583"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q64583",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64583"
}
]
}
]
},
{
"uniprot_ac": "Q64678",
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q64678",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64678"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
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{
"id": "Q64678",
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"url": "https://www.uniprot.org/uniprot/Q64678"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q64678",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64678"
}
]
}
]
},
{
"uniprot_ac": "Q64680",
"gene_name": "Cyp2d4",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q64680",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64680"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q64680",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64680"
}
]
}
]
},
{
"uniprot_ac": "Q6V0L0",
"gene_name": "CYP26C1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q6V0L0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6V0L0"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q6V0L0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6V0L0"
}
]
}
]
},
{
"uniprot_ac": "Q6XVG2",
"gene_name": "Cyp2c54",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q6XVG2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6XVG2"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q6XVG2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6XVG2"
}
]
}
]
},
{
"uniprot_ac": "Q7Z449",
"gene_name": "CYP2U1",
"activity": [
{
"ec_number": "1.14.14.80",
"activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q7Z449",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z449"
}
]
},
{
"ec_number": "1.14.14.-",
"activity": "",
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{
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]
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]
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{
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}
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{
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}
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]
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{
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