{ "uniprot_canonical_ac": "P11308-4", "uniprot_ac": "P11308", "uniprot_id": "ERG_HUMAN", "mass": { "chemical_mass": 53838.0, "monoisotopic_mass": 53838.0 }, "refseq": { "ac": "NP_001129626", "name": "transcriptional regulator ERG isoform 3", "summary": "This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129626" }, "gene_names": [ { "name": "ERG", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P11308", "id": "P11308" }, { "name": "ERG", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129626", "id": "NP_001129626" }, { "name": "erg-3; LMPHM14; p55", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129626", "id": "NP_001129626" } ], "protein_names": [ { "name": "Transcriptional regulator ERG", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P11308" }, { "name": "Transforming protein ERG", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P11308" }, { "name": "transcriptional regulator ERG isoform 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129626", "id": "NP_001129626" }, { "name": "v-ets avian erythroblastosis virus E26 oncogene related; ets-related; ERG, ETS transcription factor; FUS/ERG fusion protein; v-ets erythroblastosis virus E26 oncogene like; transcriptional regulator ERG (transforming protein ERG); TMPRSS2/ERG fusion; v-ets erythroblastosis virus E26 oncogene homolog; v-ets avian erythroblastosis virus E26 oncogene homolog", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129626", "id": "NP_001129626" } ], "function": [ { "annotation": "A complex with poly(A)-binding protein and EWS facilitates the transcriptional function of oncogenic ETS transcription factors in prostate cells.", "evidence": [ { "database": "RefSeq", "id": "NP_001129626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129626" }, { "database": "PubMed", "id": "37956771", "url": "https://glygen.org/publication/PubMed/37956771" } ] }, { "annotation": "Characterization of native ERG and Tmprss2:ERG variants reveals that their different oncogenic potential is affected by the status of the Ets domain and the configuration of the 5' UTR region", "evidence": [ { "database": "RefSeq", "id": "NP_001129626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129626" }, { "database": "PubMed", "id": "23472063", "url": "https://glygen.org/publication/PubMed/23472063" } ] }, { "annotation": "Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge.", "evidence": [ { "database": "RefSeq", "id": "NP_001129626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129626" }, { "database": "PubMed", "id": "37317853", "url": "https://glygen.org/publication/PubMed/37317853" } ] }, { "annotation": "ERG Status at the Margin Is Associated With Biochemical Recurrence After Radical Prostatectomy With Positive Surgical Margins.", "evidence": [ { "database": "RefSeq", "id": "NP_001129626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129626" }, { "database": "PubMed", "id": "36828362", "url": "https://glygen.org/publication/PubMed/36828362" } ] }, { "annotation": "Gain-of-function mutant p53 together with ERG proto-oncogene drive prostate cancer by beta-catenin activation and pyrimidine synthesis. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001129626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129626" }, { "database": "PubMed", "id": "37537199", "url": "https://glygen.org/publication/PubMed/37537199" } ] }, { "annotation": "Intercellular adhesion molecule 2 as a novel prospective tumor suppressor induced by ERG promotes ubiquitination-mediated radixin degradation to inhibit gastric cancer tumorigenicity and metastasis. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001129626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129626" }, { "database": "PubMed", "id": "37759298", "url": "https://glygen.org/publication/PubMed/37759298" } ] }, { "annotation": "This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014].", "evidence": [ { "database": "RefSeq", "id": "NP_001129626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129626" } ] }, { "annotation": "Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.", "evidence": [ { "database": "UniProtKB", "id": "P11308", "url": "https://www.uniprot.org/uniprot/P11308#function" } ] } ], "disease": [ { "disease_id": "DOID:3369", "recommended_name": { "id": "DOID:3369", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3369", "name": "Ewing sarcoma", "description": "A connective tissue cancer that has_material_basis_in neural crest cells derives_from undeveloped, undifferentiated neuroectoderm." }, "synonyms": [ { "id": "DOID:3369", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3369", "name": "Ewing's sarcoma/peripheral primitive neuroectodermal tumor", "description": "" }, { "id": "DOID:3369", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3369", "name": "localized peripheral primitive neuroectodermal tumor", "description": "" }, { "id": "DOID:3369", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3369", "name": "Ewing's family localized tumor", "description": "" }, { "id": "DOID:3369", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3369", "name": "Ewing's tumor", "description": "" }, { "id": "DOID:3369", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3369", "name": "Ewings sarcoma", "description": "" }, { "id": "DOID:3369", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3369", "name": "Ewings sarcoma-primitive neuroectodermal tumor", "description": "" }, { "id": "DOID:3369", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3369", "name": "PNET of Thoracopulmonary Region", "description": "" }, { "id": "DOID:3369", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3369", "name": "localized Ewing sarcoma", "description": "" }, { "id": "DOID:3369", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3369", "name": "localized Ewing's sarcoma", "description": "" }, { "id": "DOID:3369", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3369", "name": "localized Ewing's tumor", "description": "" }, { "id": "DOID:3369", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3369", "name": "peripheral primitive neuroectodermal tumor", "description": "" }, { "id": "DOID:3369", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3369", "name": "localized Ewing's sarcoma/peripheral primitive neuroectodermal tumor", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "Ewing sarcoma", "description": "A small round cell tumor that lacks morphologic, immunohistochemical, and electron microscopic evidence of neuroectodermal differentiation. It represents one of the two ends of the spectrum called Ewing sarcoma/peripheral neuroectodermal tumor. It affects mostly males under age 20, and it can occur in soft tissue or bone. Pain and the presence of a mass are the most common clinical symptoms." }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "ES", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "Ewing sarcoma", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "Ewing's family localised tumour", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "Ewing's family localized tumor", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "Ewing's sarcoma", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "Ewing's tumor", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "Ewing's tumour", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "Ewings sarcoma", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "PNET of Thoracopulmonary region", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "Ewing tumor", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "Ewing tumour", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "Ewing's sarcoma/peripheral primitive neuroectodermal tumour", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "Ewings sarcoma-primitive neuroectodermal tumor", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "Ewings sarcoma-primitive neuroectodermal tumour", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "localised Ewing sarcoma", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "localised Ewing's sarcoma", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "localised Ewing's sarcoma/peripheral primitive neuroectodermal tumour", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "localised Ewing's tumour", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "localised peripheral primitive neuroectodermal tumour", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "localized Ewing sarcoma", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "localized Ewing's sarcoma", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "localized Ewing's sarcoma/peripheral primitive neuroectodermal tumor", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "localized Ewing's tumor", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "localized peripheral primitive neuroectodermal tumor", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "neuroepithelioma", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "neuroepithelioma, peripheral", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "peripheral primitive neuroectodermal tumour", "description": "" }, { "id": "MONDO:0012817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012817", "name": "sarcoma, Ewing's", "description": "" }, { "id": "MIM:612219", "resource": "MIM", "url": "https://www.omim.org/entry/612219", "name": "Ewing sarcoma", "description": "Ewing sarcoma" } ], "evidence": [ { "id": "612219", "database": "MIM", "url": "https://www.omim.org/entry/612219" } ] } ], "snv": [ { "evidence": [ { "id": "P11308", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P11308" } ], "glycoeffect": [], "start_pos": 127, "end_pos": 127, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "V", "sequence_mut": "M", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "21", "chr_pos": "38423419", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "V127", "disease": [ { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] }, { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL 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"name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, 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"http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", 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"id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine 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"MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "P11308", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11308" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P11308", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11308" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "P11308", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11308" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P11308", "url": "https://www.uniprot.org/uniprot/P11308" } ], "common_name": "Human" } ], "gene": [ { "name": "ERG", "url": "https://www.uniprot.org/uniprot/P11308", "locus": { "chromosome": "21", "start_pos": 38380027, "end_pos": 38661780, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000157554", "url": "https://www.ensembl.org/id/ENSG00000157554" } ] } } ], "crossref": [ { "id": "ENSG00000157554", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000157554", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "P11308", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P11308", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "cd08540", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08540", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL1293191", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL1293191", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "ERG", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=ERG", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "2078", "url": "https://www.ncbi.nlm.nih.gov/gene/2078", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "3446", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3446", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "P11308", "url": "https://www.ebi.ac.uk/intact/interactors/id:P11308*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000418", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000418", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003118", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003118", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046328", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046328", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:2078", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:2078", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "165080", "url": "http://www.omim.org/entry/165080", "database": "MIM", "categories": [ "Other" ] }, { "id": "612219", "url": "http://www.omim.org/entry/612219", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_P11308", "url": "https://www.nextprot.org/entry/NX_P11308", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "P11308", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11308", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "RVPQQEW", "url": "https://omabrowser.org/oma/group/RVPQQEW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2882052at2759", "url": "http://www.orthodb.org/?query=2882052at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11849", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11849", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11849:SF216", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11849:SF216", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "1SXE", "url": "https://www.rcsb.org/structure/1SXE", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4IRG", "url": "https://www.rcsb.org/structure/4IRG", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4IRH", "url": "https://www.rcsb.org/structure/4IRH", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4IRI", "url": "https://www.rcsb.org/structure/4IRI", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5YBC", "url": "https://www.rcsb.org/structure/5YBC", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5YBD", "url": "https://www.rcsb.org/structure/5YBD", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6VGE", "url": "https://www.rcsb.org/structure/6VGE", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6VGG", "url": "https://www.rcsb.org/structure/6VGG", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00178", "url": "http://pfam.xfam.org/family/PF00178", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02198", "url": "http://pfam.xfam.org/family/PF02198", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P11308", "url": "https://pharos.nih.gov/targets/P11308", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_P11308", "url": "http://purl.obolibrary.org/obo/PR_P11308", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001129626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129626", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P11308", "url": "https://www.uniprot.org/uniprot/P11308", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P11308-1", "url": "https://www.uniprot.org/uniprot/P11308-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P11308-2", "url": "https://www.uniprot.org/uniprot/P11308-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P11308-3", "url": "https://www.uniprot.org/uniprot/P11308-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P11308-4", "url": "https://www.uniprot.org/uniprot/P11308-4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P11308-5", "url": "https://www.uniprot.org/uniprot/P11308-5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P11308-6", "url": "https://www.uniprot.org/uniprot/P11308-6", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY", "length": 479, "header": "sp|P11308-4|ERG_HUMAN Isoform 4 of Transcriptional regulator ERG OS=Homo sapiens OX=9606 GN=ERG PE=1 SV=3 CANONICAL=P11308-4" }, "isoforms": [ { "isoform_ac": "P11308-1", "url": "", "sequence": { "sequence": "MIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY", "length": 462, "header": "sp|P11308-1|ERG_HUMAN Isoform 1 of Transcriptional regulator ERG OS=Homo sapiens OX=9606 GN=ERG PE=1 SV=3 CANONICAL=P11308-4" }, "locus": { "chromosome": "21", "start_pos": 38575700, "end_pos": 38383406, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000442448.5", "url": "https://www.ensembl.org/id/ENST00000442448.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000394694.1", "url": "https://www.ensembl.org/id/ENSP00000394694.1" } ] } }, { "isoform_ac": "P11308-2", "url": "", "sequence": { "sequence": "MVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY", "length": 363, "header": "sp|P11308-2|ERG_HUMAN Isoform 2 of Transcriptional regulator ERG OS=Homo sapiens OX=9606 GN=ERG PE=1 SV=3 CANONICAL=P11308-4" }, "locus": { "chromosome": "21", "start_pos": 38423521, "end_pos": 38383406, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000398897.5", "url": "https://www.ensembl.org/id/ENST00000398897.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000381871.1", "url": "https://www.ensembl.org/id/ENSP00000381871.1" } ] } }, { "isoform_ac": "P11308-3", "url": "", "sequence": { "sequence": "MIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY", "length": 486, "header": "sp|P11308-3|ERG_HUMAN Isoform 3 of Transcriptional regulator ERG OS=Homo sapiens OX=9606 GN=ERG PE=1 SV=3 CANONICAL=P11308-4" }, "locus": { "chromosome": "21", "start_pos": 38575700, "end_pos": 38383406, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000398919.6", "url": "https://www.ensembl.org/id/ENST00000398919.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000381891.2", "url": "https://www.ensembl.org/id/ENSP00000381891.2" } ] } }, { "isoform_ac": "P11308-4", "url": "", "sequence": { "sequence": "MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY", "length": 479, "header": "sp|P11308-4|ERG_HUMAN Isoform 4 of Transcriptional regulator ERG OS=Homo sapiens OX=9606 GN=ERG PE=1 SV=3 CANONICAL=P11308-4" }, "locus": { "chromosome": "21", "start_pos": 38498380, "end_pos": 38383406, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000288319.12", "url": "https://www.ensembl.org/id/ENST00000288319.12" }, { "database": "Ensembl Peptide", "id": "ENSP00000288319.7", "url": "https://www.ensembl.org/id/ENSP00000288319.7" } ] } }, { "isoform_ac": "P11308-5", "url": "", "sequence": { "sequence": "MIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGWTQ", "length": 317, "header": "sp|P11308-5|ERG_HUMAN Isoform 5 of Transcriptional regulator ERG OS=Homo sapiens OX=9606 GN=ERG PE=1 SV=3 CANONICAL=P11308-4" }, "locus": {} }, { "isoform_ac": "P11308-6", "url": "", "sequence": { "sequence": "MIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPGTKTPLCDLFIERHPRCPAEIRALSHVIQRELIPELKPVPDSLILPLLIWRLNPLKPFHSKTTLKELRAD", "length": 325, "header": "sp|P11308-6|ERG_HUMAN Isoform 6 of Transcriptional regulator ERG OS=Homo sapiens OX=9606 GN=ERG PE=1 SV=3 CANONICAL=P11308-4" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "P11308", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11308" }, { "id": "29485866", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29485866" } ] } ], "phosphorylation": [ { "start_pos": 215, "end_pos": 215, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P11308", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11308" }, { "database": "PubMed", "id": "25885538", "url": "" } ], "site_lbl": "Ser215" }, { "start_pos": 48, "end_pos": 48, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P11308", "url": "https://www.uniprot.org/uniprot/P11308" } ], "site_lbl": "Ser48" }, { "start_pos": 81, "end_pos": 81, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P11308", "url": "https://www.uniprot.org/uniprot/P11308" }, { "database": "iPTMnet", "id": "P11308", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11308" }, { "database": "PubMed", "id": "23918819", "url": "" } ], "site_lbl": "Ser81" }, { "start_pos": 86, "end_pos": 86, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P11308", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11308" }, { "database": "PubMed", "id": "15302935", "url": "https://glygen.org/publication/PubMed/15302935" } ], "site_lbl": "Ser86" }, { "start_pos": 96, "end_pos": 96, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P11308", "url": "https://www.uniprot.org/uniprot/P11308" }, { "database": "iPTMnet", "id": "P11308", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11308" }, { "database": "PubMed", "id": "28887309", "url": "" }, { "database": "PubMed", "id": "34314419", "url": "https://glygen.org/publication/PubMed/34314419" } ], "site_lbl": "Ser96" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Detailed mapping of the ERG-ETS2 interval of human chromosome 21 and comparison with the region of conserved synteny on mouse chromosome 16.", "journal": "Gene", "date": "2004", "authors": "Owczarek C M, Portbury K J, Hardy M P, O'Leary D A, Kudoh J, Shibuya K, Shimizu N, Kola I, Hertzog P J", "evidence": [ { "database": "UniProtKB", "id": "P11308", "url": "https://www.uniprot.org/uniprot/P11308" } ], "reference": [ { "type": "PubMed", "id": "14693372", "url": "https://glygen.org/publication/PubMed/14693372" } ] }, { "title": "Large-scale characterization of HeLa cell nuclear phosphoproteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2004", "authors": "Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li J, Cohn MA, Cantley LC, Gygi SP", "evidence": [ { "database": "iPTMnet", "id": "P11308-4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11308-4" } ], "reference": [ { "type": "PubMed", "id": "15302935", "url": "https://glygen.org/publication/PubMed/15302935" } ] }, { "title": "Diversity in structure and function of the Ets family PNT domains.", "journal": "J. Mol. Biol.", "date": "2004", "authors": "Mackereth Cameron D, Sch\u00e4rpf Manuela, Gentile Lisa N, MacIntosh Scott E, Slupsky Carolyn M, McIntosh Lawrence P", "evidence": [ { "database": "UniProtKB", "id": "P11308", "url": "https://www.uniprot.org/uniprot/P11308" } ], "reference": [ { "type": "PubMed", "id": "15351649", "url": "https://glygen.org/publication/PubMed/15351649" } ] }, { "title": "ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22).", "journal": "Leuk. Res.", "date": "2006", "authors": "Moore Steven D P, Offor Onyinye, Ferry Judith A, Amrein Philip C, Morton Cynthia C, Dal Cin Paola", "evidence": [ { "database": "UniProtKB", "id": "P11308", "url": "https://www.uniprot.org/uniprot/P11308" } ], "reference": [ { "type": "PubMed", "id": "16303180", "url": "https://glygen.org/publication/PubMed/16303180" } ] }, { "title": "Molecular composition of IMP1 ribonucleoprotein granules.", "journal": "Mol. Cell. Proteomics", "date": "2007", "authors": "Jonson L, Vikesaa J, Krogh A, Nielsen LK, Hansen Tv, Borup R, Johnsen AH, Christiansen J, Nielsen FC", "evidence": [ { "database": "UniProtKB", "id": "P11308", "url": "https://www.uniprot.org/uniprot/P11308" } ], "reference": [ { "type": "PubMed", "id": "17289661", "url": "https://glygen.org/publication/PubMed/17289661" } ] }, { "title": "5' UTR control of native ERG and of Tmprss2:ERG variants activity in prostate cancer.", "journal": "PloS one", "date": "2013", "authors": "Zammarchi F, Boutsalis G, Cartegni L", "evidence": [ { "database": "RefSeq", "id": "NP_001129626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129626" } ], "reference": [ { "type": "PubMed", "id": "23472063", "url": "https://glygen.org/publication/PubMed/23472063" } ] }, { "title": "O-GlcNAc Transferase Recognizes Protein Substrates Using an Asparagine Ladder in the Tetratricopeptide Repeat (TPR) Superhelix.", "journal": "Journal of the American Chemical Society", "date": "2018", "authors": "Levine ZG, Fan C, Melicher MS, Orman M, Benjamin T, Walker S", "evidence": [ { "database": "O-GlcNAc Database", "id": "P11308", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11308" } ], "reference": [ { "type": "PubMed", "id": "29485866", "url": "https://glygen.org/publication/PubMed/29485866" } ] }, { "title": "erg, a human ets-related gene on chromosome 21: alternative splicing, polyadenylation, and translation.", "journal": "Science", "date": "1987", "authors": "Rao VN, Papas TS, Reddy ES", "evidence": [ { "database": "UniProtKB", "id": "P11308", "url": "https://www.uniprot.org/uniprot/P11308" } ], "reference": [ { "type": "PubMed", "id": "3299708", "url": "https://glygen.org/publication/PubMed/3299708" } ] }, { "title": "Ras/ERK and PI3K/AKT signaling differentially regulate oncogenic ERG mediated transcription in prostate cells.", "journal": "PLoS genetics", "date": "2021", "authors": "Strittmatter BG, Jerde TJ, Hollenhorst PC", "evidence": [ { "database": "iPTMnet", "id": "P11308", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11308" } ], "reference": [ { "type": "PubMed", "id": "34314419", "url": "https://glygen.org/publication/PubMed/34314419" } ] }, { "title": "The erg gene: a human gene related to the ets oncogene.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1987", "authors": "Reddy ES, Rao VN, Papas TS", "evidence": [ { "database": "UniProtKB", "id": "P11308", "url": "https://www.uniprot.org/uniprot/P11308" } ], "reference": [ { "type": "PubMed", "id": "3476934", "url": "https://glygen.org/publication/PubMed/3476934" } ] }, { "title": "ERG Status at the Margin Is Associated With Biochemical Recurrence After Radical Prostatectomy With Positive Surgical Margins.", "journal": "Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc", "date": "2023-07", "authors": "Salles Daniela C, Mendes Adrianna A, Han Misop, Partin Alan W, Trock Bruce J, Jing Yuezhou, Lotan Tamara L", "evidence": [ { "database": "RefSeq", "id": "NP_001129626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129626" } ], "reference": [ { "type": "PubMed", "id": "36828362", "url": "https://glygen.org/publication/PubMed/36828362" } ] }, { "title": "Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge.", "journal": "Arteriosclerosis, thrombosis, and vascular biology", "date": "2023-08", "authors": "Schafer Christopher M, Martin-Almedina Silvia, Kurylowicz Katarzyna, Dufton Neil, Osuna-Almagro Lourdes, Wu Meng-Ling, Johnson Charmain F, Shah Aarti V, Haskard Dorian O, Buxton Andrianna, Willis Erika, Wheeler Kate, Turner Sean, Chlebicz Magdalena, Scott Rizaldy P, Kovats Susan, Cleuren Audrey, Birdsey Graeme M, Randi Anna M, Griffin Courtney T", "evidence": [ { "database": "RefSeq", "id": "NP_001129626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129626" } ], "reference": [ { "type": "PubMed", "id": "37317853", "url": "https://glygen.org/publication/PubMed/37317853" } ] }, { "title": "Gain-of-function mutant p53 together with ERG proto-oncogene drive prostate cancer by beta-catenin activation and pyrimidine synthesis.", "journal": "Nature communications", "date": "2023-08-03", "authors": "Ding Donglin, Blee Alexandra M, Zhang Jianong, Pan Yunqian, Becker Nicole A, Maher L James, Jimenez Rafael, Wang Liguo, Huang Haojie", "evidence": [ { "database": "RefSeq", "id": "NP_001129626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129626" } ], "reference": [ { "type": "PubMed", "id": "37537199", "url": "https://glygen.org/publication/PubMed/37537199" } ] }, { "title": "Intercellular adhesion molecule 2 as a novel prospective tumor suppressor induced by ERG promotes ubiquitination-mediated radixin degradation to inhibit gastric cancer tumorigenicity and metastasis.", "journal": "Journal of translational medicine", "date": "2023-09-27", "authors": "Tang Xiaocheng, Huang Jintuan, Jiang Yingming, Qiu Jun, Li Tuoyang, Li Weiyao, Chen Zijian, Huang Zhenze, Yu Xihu, Yang Tao, Ji Xiang, Tan Rongchang, Lv Li, Yang Zuli, Chen Hao", "evidence": [ { "database": "RefSeq", "id": "NP_001129626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129626" } ], "reference": [ { "type": "PubMed", "id": "37759298", "url": "https://glygen.org/publication/PubMed/37759298" } ] }, { "title": "A complex with poly(A)-binding protein and EWS facilitates the transcriptional function of oncogenic ETS transcription factors in prostate cells.", "journal": "The Journal of biological chemistry", "date": "2023-12", "authors": "Greulich Benjamin M, Rajendran Saranya, Downing Nicholas F, Nicholas Taylor R, Hollenhorst Peter C", "evidence": [ { "database": "RefSeq", "id": "NP_001129626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129626" } ], "reference": [ { "type": "PubMed", "id": "37956771", "url": "https://glygen.org/publication/PubMed/37956771" } ] }, { "title": "ERG gene is translocated in an Ewing's sarcoma cell line.", "journal": "Cancer Genet. Cytogenet.", "date": "1994", "authors": "Dunn T, Praissman L, Hagag N, Viola M V", "evidence": [ { "database": "UniProtKB", "id": "P11308", "url": "https://www.uniprot.org/uniprot/P11308" } ], "reference": [ { "type": "PubMed", "id": "8076344", "url": "https://glygen.org/publication/PubMed/8076344" } ] }, { "title": "An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation.", "journal": "Cancer Res.", "date": "1994", "authors": "Ichikawa H, Shimizu K, Hayashi Y, Ohki M", "evidence": [ { "database": "UniProtKB", "id": "P11308", "url": "https://www.uniprot.org/uniprot/P11308" } ], "reference": [ { "type": "PubMed", "id": "8187069", "url": "https://glygen.org/publication/PubMed/8187069" } ] }, { "title": "Differentially spliced erg-3 product functions as a transcriptional activator.", "journal": "Oncogene", "date": "1994", "authors": "Prasad D D, Rao V N, Lee L, Reddy E S", "evidence": [ { "database": "UniProtKB", "id": "P11308", "url": "https://www.uniprot.org/uniprot/P11308" } ], "reference": [ { "type": "PubMed", "id": "8290279", "url": "https://glygen.org/publication/PubMed/8290279" } ] } ], "pathway": [ { "id": "hsa:2078", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:2078", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZMT0-1", "protein_name": "ETS transcription factor ERG", "gene_name": "Erg", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MIQTVPDPEAQIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVTKGGKMVGSPDTVGMSYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLLDVDVLLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSTWTGHSHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSNCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHTHPQKMNFVAPHPPALPVTSSSFFATPNPYWNSPTGGIYPNTRLPASHMPSHLGTYY", "length": 486 }, "evidence": [ { "id": "45925884", "url": "http://www.informatics.jax.org/homology/45925884", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P81270-1", "protein_name": "Transcriptional regulator ERG", "gene_name": "Erg", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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