{ "uniprot_canonical_ac": "P11234-1", "uniprot_ac": "P11234", "uniprot_id": "RALB_HUMAN", "mass": { "chemical_mass": 23409.0, "monoisotopic_mass": 23409.0 }, "refseq": { "ac": "NP_002872", "name": "ras-related protein Ral-B", "summary": "This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002872" }, "gene_names": [ { "name": "RALB", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P11234", "id": "P11234" }, { "name": "RALB", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002872", "id": "NP_002872" } ], "protein_names": [ { "name": "Ras-related protein Ral-B", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P11234" }, { "name": "3.6.5.2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P11234" }, { "name": "RAS-like protein B; v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein); ras related GTP binding protein B; RALB Ras like proto-oncogene B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002872", "id": "NP_002872" }, { "name": "ras-related protein Ral-B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002872", "id": "NP_002872" } ], "function": [ { "annotation": "MicroRNA-139 inhibits pancreatic-cancer carcinogenesis by suppressing RalB via the Ral/RAC/PI3K pathway.", "evidence": [ { "database": "RefSeq", "id": "NP_002872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002872" }, { "database": "PubMed", "id": "33290747", "url": "https://glygen.org/publication/PubMed/33290747" } ] }, { "annotation": "Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking (PubMed:10393179, PubMed:17875936, PubMed:18756269). Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (PubMed:17875936). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269). Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors (PubMed:10393179).", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234#function" }, { "database": "UniProtKB", "id": "P36860", "url": "https://www.uniprot.org/uniprot/P36860#function" }, { "database": "PubMed", "id": "18756269", "url": "https://glygen.org/publication/PubMed/18756269" }, { "database": "PubMed", "id": "17875936", "url": "https://glygen.org/publication/PubMed/17875936" }, { "database": "PubMed", "id": "10393179", "url": "https://glygen.org/publication/PubMed/10393179" } ] }, { "annotation": "RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_002872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002872" }, { "database": "PubMed", "id": "33122623", "url": "https://glygen.org/publication/PubMed/33122623" } ] }, { "annotation": "Ral GTPase-activating protein regulates the malignancy of pancreatic ductal adenocarcinoma.", "evidence": [ { "database": "RefSeq", "id": "NP_002872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002872" }, { "database": "PubMed", "id": "34009715", "url": "https://glygen.org/publication/PubMed/34009715" } ] }, { "annotation": "This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_002872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002872" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "P11234", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P11234" } ], "glycoeffect": [], "start_pos": 106, "end_pos": 106, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "E", "sequence_mut": "K", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (5).", "chr_id": "2", "chr_pos": "120286075", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "E106", "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] }, { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": 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"resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] }, { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": 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"https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "mutagenesis": [ { "start_pos": 1, "end_pos": 11, "sequence_org": "MAANKSKGQSS", "sequence_mut": "", "comment": "No effect on cytokinesis. Impaired cytokinesis, as shown by increased number of binucleate cells; when associated with V-23.", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" }, { "database": "PubMed", "id": "18756269", "url": "https://glygen.org/publication/PubMed/18756269" } ] }, { "start_pos": 203, "end_pos": 203, "sequence_org": "C", "sequence_mut": "S", "comment": "Loss of geranylgeranylation and membrane localization.", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" }, { "database": "PubMed", "id": "17875936", "url": "https://glygen.org/publication/PubMed/17875936" } ] }, { "start_pos": 206, "end_pos": 206, "sequence_org": "L", "sequence_mut": "S", "comment": "Converts geranyl-geranylation to farnesylation. No effect on membrane localization. Confers resistance to GGTI-induced pancreatic cancer cell apoptosis, but not to GGTI-dependent inhibition of anchorage-independent proliferation.", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" }, { "database": "PubMed", "id": "17875936", "url": "https://glygen.org/publication/PubMed/17875936" } ] }, { "start_pos": 23, "end_pos": 23, "sequence_org": "G", "sequence_mut": "V", "comment": "Impaired cytokinesis, as shown by increased number of binucleate cells. Impaired cytokinesis; when associated with 1-M--S-11 or N-49. No effect on cytokinesis; when associated with R-38, W-48 or E-49. No effect on interaction with EXOC2 and EXOC8. Decreased interaction with EXOC2 and EXOC8; when associated with R-38 or W-48.", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" }, { "database": "PubMed", "id": "18756269", "url": "https://glygen.org/publication/PubMed/18756269" } ] }, { "start_pos": 38, "end_pos": 38, "sequence_org": "E", "sequence_mut": "R", "comment": "No effect on cytokinesis. No effect on cytokinesis; when associated with V-23. Decreased interaction with EXOC2 and EXOC8; when associated with V-23.", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" }, { "database": "PubMed", "id": "18756269", "url": "https://glygen.org/publication/PubMed/18756269" } ] }, { "start_pos": 46, "end_pos": 46, "sequence_org": "T", "sequence_mut": "A", "comment": "Reduces the binding affinity to EXOC2 effector.", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" }, { "database": "PubMed", "id": "19166349", "url": "https://glygen.org/publication/PubMed/19166349" } ] }, { "start_pos": 46, "end_pos": 46, "sequence_org": "T", "sequence_mut": "S", "comment": "Reduces the binding affinity to EXOC2 effector.", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" }, { "database": "PubMed", "id": "19166349", "url": "https://glygen.org/publication/PubMed/19166349" } ] }, { "start_pos": 48, "end_pos": 48, "sequence_org": "A", "sequence_mut": "W", "comment": "Impaired abscission, the last step of cytokinesis, as shown by the accumulation of bridged cells. No effect on cytokinesis; when associated with V-23. Decreased interaction with EXOC2 and EXOC8; when associated with V-23.", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" }, { "database": "PubMed", "id": "18756269", "url": "https://glygen.org/publication/PubMed/18756269" } ] }, { "start_pos": 49, "end_pos": 49, "sequence_org": "D", "sequence_mut": "E", "comment": "Impaired abscission, the last step of cytokinesis. No effect on cytokinesis; when associated with V-23.", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" }, { "database": "PubMed", "id": "18756269", "url": "https://glygen.org/publication/PubMed/18756269" } ] }, { "start_pos": 49, "end_pos": 49, "sequence_org": "D", "sequence_mut": "N", "comment": "No effect on cytokinesis. Impaired cytokinesis, as shown by increased number of binucleate cells; when associated with V-23.", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" }, { "database": "PubMed", "id": "18756269", "url": "https://glygen.org/publication/PubMed/18756269" } ] }, { "start_pos": 72, "end_pos": 72, "sequence_org": "Q", "sequence_mut": "L", "comment": "Loss of GTPase activity.", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" }, { "database": "PubMed", "id": "19166349", "url": "https://glygen.org/publication/PubMed/19166349" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "94.65", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000144118", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000144118" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "94.88", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000144118", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000144118" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "92.25", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000144118", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000144118" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "88.24", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000144118", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000144118" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "94.44", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000144118", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000144118" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "96.31", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000144118", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000144118" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "92.39", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000144118", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000144118" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "92.69", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000144118", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000144118" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "89.99", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000144118", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000144118" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "93.49", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000144118", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000144118" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "88.12", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000144118", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000144118" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "92.28", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000144118", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000144118" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "92.43", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000144118", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000144118" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P11234", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11234" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", 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"https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P11234", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11234" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", 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{ "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed 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cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P11234", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11234" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11234" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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"database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:5899", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:5899", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "179551", "url": "http://www.omim.org/entry/179551", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_P11234", "url": "https://www.nextprot.org/entry/NX_P11234", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "FMNISKS", "url": "https://omabrowser.org/oma/group/FMNISKS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "8685at2759", "url": "http://www.orthodb.org/?query=8685at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24070", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24070", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24070:SF199", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24070:SF199", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "2KE5", "url": "https://www.rcsb.org/structure/2KE5", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2KWI", "url": "https://www.rcsb.org/structure/2KWI", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6ZQT", "url": "https://www.rcsb.org/structure/6ZQT", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6ZRN", "url": "https://www.rcsb.org/structure/6ZRN", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00071", "url": "http://pfam.xfam.org/family/PF00071", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P11234", "url": "https://pharos.nih.gov/targets/P11234", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_P11234", "url": "http://purl.obolibrary.org/obo/PR_P11234", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-171007", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-171007", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_002872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002872", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "C9J6B1", "url": "https://www.uniprot.org/uniprot/C9J6B1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9J6B1-1", "url": "https://www.uniprot.org/uniprot/C9J6B1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9JQB3", "url": "https://www.uniprot.org/uniprot/C9JQB3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9JQB3-1", "url": "https://www.uniprot.org/uniprot/C9JQB3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9JYR1", "url": "https://www.uniprot.org/uniprot/C9JYR1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9JYR1-1", "url": "https://www.uniprot.org/uniprot/C9JYR1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F8WEQ6", "url": "https://www.uniprot.org/uniprot/F8WEQ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F8WEQ6-1", "url": "https://www.uniprot.org/uniprot/F8WEQ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P11234-1", "url": "https://www.uniprot.org/uniprot/P11234-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P11234-2", "url": "https://www.uniprot.org/uniprot/P11234-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P11234-3", "url": "https://www.uniprot.org/uniprot/P11234-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAANKSKGQSSLALHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLLVFSITEHESFTATAEFREQILRVKAEEDKIPLLVVGNKSDLEERRQVPVEEARSKAEEWGVQYVETSAKTRANVDKVFFDLMREIRTKKMSENKDKNGKKSSKNKKSFKERCCLL", "length": 206, "header": "sp|P11234-1|RALB_HUMAN Isoform 1 of Ras-related protein Ral-B OS=Homo sapiens OX=9606 GN=RALB PE=1 SV=1 CANONICAL=P11234-1" }, "isoforms": [ { "isoform_ac": "C9J6B1-1", "url": "", "sequence": { "sequence": "MAANKSKGQSSLALHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLLVFSITEHESFTATAEFREQILRVKAEEDKIPLLVVGNKSDLEERRQVPVEEARSKAEEWGVQYVETSAKTRANVDK", "length": 167, "header": "tr|C9J6B1-1|RALB_HUMAN Computationally mapped isoform of Ras-related protein Ral-B OS=Homo sapiens OX=9606 GN=RALB PE=1 SV=1 CANONICAL=P11234-1" }, "locus": { "chromosome": "2", "start_pos": 120289757, "end_pos": 120278665, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000412383.5", "url": "https://www.ensembl.org/id/ENST00000412383.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000398162.1", "url": "https://www.ensembl.org/id/ENSP00000398162.1" } ] } }, { "isoform_ac": "C9JQB3-1", "url": "", "sequence": { "sequence": "MKQRQSALQWVICVSQPQKTSEMAANKSKGQSSLALHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLLVFSITEHESFTATAEFREQILRVKAEEDKIPLLVVGNKSDLEERRQVPVEEARSKAEE", "length": 171, "header": "tr|C9JQB3-1|RALB_HUMAN Computationally mapped isoform of Ras-related protein Ral-B OS=Homo sapiens OX=9606 GN=RALB PE=1 SV=1 CANONICAL=P11234-1" }, "locus": { "chromosome": "2", "start_pos": 120289703, "end_pos": 120240107, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000447591.5", "url": "https://www.ensembl.org/id/ENST00000447591.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000402866.1", "url": "https://www.ensembl.org/id/ENSP00000402866.1" } ] } }, { "isoform_ac": "C9JYR1-1", "url": "", "sequence": { "sequence": "MAANKSKGQSSLALHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLLVFSITEHESFTATAEFREQIL", "length": 112, "header": "tr|C9JYR1-1|RALB_HUMAN Computationally mapped isoform of Ras-related protein Ral-B OS=Homo sapiens OX=9606 GN=RALB PE=1 SV=1 CANONICAL=P11234-1" }, "locus": { "chromosome": "2", "start_pos": 120289592, "end_pos": 120278665, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000449649.1", "url": "https://www.ensembl.org/id/ENST00000449649.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000407062.1", "url": "https://www.ensembl.org/id/ENSP00000407062.1" } ] } }, { "isoform_ac": "F8WEQ6-1", "url": "", "sequence": { "sequence": "MAANKSKGQSSLALHKVIMVGSGGVGKSALTLQFMYDEECFKIIGI", "length": 46, "header": "tr|F8WEQ6-1|F8WEQ6_HUMAN Computationally mapped isoform of RAS like proto-oncogene B OS=Homo sapiens OX=9606 GN=RALB PE=1 SV=1 CANONICAL=P11234-1" }, "locus": { "chromosome": "2", "start_pos": 120280858, "end_pos": 120278665, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000631312.2", "url": "https://www.ensembl.org/id/ENST00000631312.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000487037.1", "url": "https://www.ensembl.org/id/ENSP00000487037.1" } ] } }, { "isoform_ac": "P11234-1", "url": "", "sequence": { "sequence": "MAANKSKGQSSLALHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLLVFSITEHESFTATAEFREQILRVKAEEDKIPLLVVGNKSDLEERRQVPVEEARSKAEEWGVQYVETSAKTRANVDKVFFDLMREIRTKKMSENKDKNGKKSSKNKKSFKERCCLL", "length": 206, "header": "sp|P11234-1|RALB_HUMAN Isoform 1 of Ras-related protein Ral-B OS=Homo sapiens OX=9606 GN=RALB PE=1 SV=1 CANONICAL=P11234-1" }, "locus": { "chromosome": "2", "start_pos": 120293257, "end_pos": 120278665, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000420510.5", "url": "https://www.ensembl.org/id/ENST00000420510.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000414224.1", "url": "https://www.ensembl.org/id/ENSP00000414224.1" } ] } }, { "isoform_ac": "P11234-2", "url": "", "sequence": { "sequence": "MKQRQSALQWVICVSQPQKTSEMAANKSKGQSSLALHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLLVFSITEHESFTATAEFREQILRVKAEEDKIPLLVVGNKSDLEERRQVPVEEARSKAEEWGVQYVETSAKTRANVDKVFFDLMREIRTKKMSENKDKNGKKSSKNKKSFKERCCLL", "length": 228, "header": "sp|P11234-2|RALB_HUMAN Isoform 2 of Ras-related protein Ral-B OS=Homo sapiens OX=9606 GN=RALB PE=1 SV=1 CANONICAL=P11234-1" }, "locus": {} }, { "isoform_ac": "P11234-3", "url": "", "sequence": { "sequence": "MAANKSKGQSSLALHKVIMVGSGGVGKSALTLQFMNVSKSLAYDKKKYTANKKVEGILEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLLVFSITEHESFTATAEFREQILRVKAEEDKIPLLVVGNKSDLEERRQVPVEEARSKAEEWGVQYVETSAKTRANVDKVFFDLMREIRTKKMSENKDKNGKKSSKNKKSFKERCCLL", "length": 227, "header": "sp|P11234-3|RALB_HUMAN Isoform 3 of Ras-related protein Ral-B OS=Homo sapiens OX=9606 GN=RALB PE=1 SV=1 CANONICAL=P11234-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 198, "end_pos": 198, "kinase_uniprot_canonical_ac": "P17252-1", "kinase_gene_name": "PRKCA", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P11234", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11234" }, { "database": "PubMed", "id": "20940393", "url": "https://glygen.org/publication/PubMed/20940393" } ], "site_lbl": "Ser198" }, { "start_pos": 198, "end_pos": 198, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P11234", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11234" }, { "database": "PubMed", "id": "20940393", "url": "https://glygen.org/publication/PubMed/20940393" }, { "database": "PubMed", "id": "22393054", "url": "https://glygen.org/publication/PubMed/22393054" } ], "site_lbl": "Ser198" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors.", "journal": "The EMBO journal", "date": "1999-07-01", "authors": "Nakashima S, Morinaka K, Koyama S, Ikeda M, Kishida M, Okawa K, Iwamatsu A, Kishida S, Kikuchi A", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" } ], "reference": [ { "type": "PubMed", "id": "10393179", "url": "https://glygen.org/publication/PubMed/10393179" } ] }, { "title": "Ral GTPases regulate exocyst assembly through dual subunit interactions.", "journal": "J. Biol. Chem.", "date": "2003", "authors": "Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" } ], "reference": [ { "type": "PubMed", "id": "14525976", "url": "https://glygen.org/publication/PubMed/14525976" } ] }, { "title": "Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth.", "journal": "Molecular and cellular biology", "date": "2007", "authors": "Falsetti SC, Wang DA, Peng H, Carrico D, Cox AD, Der CJ, Hamilton AD, Sebti SM", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" } ], "reference": [ { "type": "PubMed", "id": "17875936", "url": "https://glygen.org/publication/PubMed/17875936" } ] }, { "title": "Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs.", "journal": "The EMBO journal", "date": "2008", "authors": "Cascone I, Selimoglu R, Ozdemir C, Del Nery E, Yeaman C, White M, Camonis J", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" } ], "reference": [ { "type": "PubMed", "id": "18756269", "url": "https://glygen.org/publication/PubMed/18756269" } ] }, { "title": "Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding.", "journal": "Biochemistry", "date": "2009", "authors": "Fenwick RB, Prasannan S, Campbell LJ, Nietlispach D, Evetts KA, Camonis J, Mott HR, Owen D", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" } ], "reference": [ { "type": "PubMed", "id": "19166349", "url": "https://glygen.org/publication/PubMed/19166349" } ] }, { "title": "The RalB-RLIP76 complex reveals a novel mode of ral-effector interaction.", "journal": "Structure", "date": "2010", "authors": "Fenwick R Brynmor, Campbell Louise J, Rajasekar Karthik, Prasannan Sunil, Nietlispach Daniel, Camonis Jacques, Owen Darerca, Mott Helen R", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" } ], "reference": [ { "type": "PubMed", "id": "20696399", "url": "https://glygen.org/publication/PubMed/20696399" } ] }, { "title": "Phosphorylation of RalB is important for bladder cancer cell growth and metastasis.", "journal": "Cancer research", "date": "2010", "authors": "Wang H, Owens C, Chandra N, Conaway MR, Brautigan DL, Theodorescu D", "evidence": [ { "database": "iPTMnet", "id": "P11234", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11234" } ], "reference": [ { "type": "PubMed", "id": "20940393", "url": "https://glygen.org/publication/PubMed/20940393" } ] }, { "title": "Chromosomal localization and cDNA sequence of human ralB, a GTP binding protein.", "journal": "Somat. Cell Mol. Genet.", "date": "1990", "authors": "Hsieh C L, Swaroop A, Francke U", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" } ], "reference": [ { "type": "PubMed", "id": "2120779", "url": "https://glygen.org/publication/PubMed/2120779" } ] }, { "title": "Phosphorylation by protein kinase Calpha regulates RalB small GTPase protein activation, subcellular localization, and effector utilization.", "journal": "The Journal of biological chemistry", "date": "2012", "authors": "Martin TD, Mitin N, Cox AD, Yeh JJ, Der CJ", "evidence": [ { "database": "iPTMnet", "id": "P11234", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11234" } ], "reference": [ { "type": "PubMed", "id": "22393054", "url": "https://glygen.org/publication/PubMed/22393054" } ] }, { "title": "Coding sequences of human ralA and ralB cDNAs.", "journal": "Nucleic Acids Res.", "date": "1989", "authors": "Chardin P, Tavitian A", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" } ], "reference": [ { "type": "PubMed", "id": "2662142", "url": "https://glygen.org/publication/PubMed/2662142" } ] }, { "title": "RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer.", "journal": "Cell death & disease", "date": "2020", "authors": "Khawaja H, Campbell A, Roberts JZ, Javadi A, O'Reilly P, McArt D, Allen WL, Majkut J, Rehm M, Bardelli A, Di Nicolantonio F, Scott CJ, Kennedy R, Vitale N, Harrison T, Sansom OJ, Longley DB, Evergren E, Van Schaeybroeck S", "evidence": [ { "database": "RefSeq", "id": "NP_002872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002872" } ], "reference": [ { "type": "PubMed", "id": "33122623", "url": "https://glygen.org/publication/PubMed/33122623" } ] }, { "title": "MicroRNA-139 inhibits pancreatic-cancer carcinogenesis by suppressing RalB via the Ral/RAC/PI3K pathway.", "journal": "Archives of biochemistry and biophysics", "date": "2021", "authors": "Wang Y, Zheng Y, Chen Q, Dai Y, Li T", "evidence": [ { "database": "RefSeq", "id": "NP_002872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002872" } ], "reference": [ { "type": "PubMed", "id": "33290747", "url": "https://glygen.org/publication/PubMed/33290747" } ] }, { "title": "Ral GTPase-activating protein regulates the malignancy of pancreatic ductal adenocarcinoma.", "journal": "Cancer science", "date": "2021", "authors": "Yoshimachi S, Shirakawa R, Cao M, Trinh DA, Gao P, Sakata N, Miyazaki K, Goto K, Miura T, Ariake K, Maeda S, Masuda K, Ishida M, Ohtsuka H, Unno M, Horiuchi H", "evidence": [ { "database": "RefSeq", "id": "NP_002872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002872" } ], "reference": [ { "type": "PubMed", "id": "34009715", "url": "https://glygen.org/publication/PubMed/34009715" } ] }, { "title": "Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity.", "journal": "J. Biol. Chem.", "date": "1995", "authors": "Jullien-Flores V, Dorseuil O, Romero F, Letourneur F, Saragosti S, Berger R, Tavitian A, Gacon G, Camonis JH", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" } ], "reference": [ { "type": "PubMed", "id": "7673236", "url": "https://glygen.org/publication/PubMed/7673236" } ] }, { "title": "Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1994", "authors": "Hofer F, Fields S, Schneider C, Martin GS", "evidence": [ { "database": "Reactome", "id": "R-HSA-171007", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-171007" } ], "reference": [ { "type": "PubMed", "id": "7972015", "url": "https://glygen.org/publication/PubMed/7972015" } ] }, { "title": "Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2.", "journal": "The EMBO journal", "date": "1995", "authors": "Ben-Levy R, Leighton IA, Doza YN, Attwood P, Morrice N, Marshall CJ, Cohen P", "evidence": [ { "database": "Reactome", "id": "R-HSA-171007", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-171007" } ], "reference": [ { "type": "PubMed", "id": "8846784", "url": "https://glygen.org/publication/PubMed/8846784" } ] } ], "pathway": [ { "id": "hsa:5899", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:5899", "resource": "KEGG Pathway" }, { "id": "R-HSA-171007", "name": "p38MAPK events", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-171007", "resource": "Reactome", "description": "p38MAPK events" } ], "orthologs": [ { "uniprot_canonical_ac": "P36860-1", "protein_name": "Ras-related protein Ral-B", "gene_name": "Ralb", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAANKGKSQGSLVLHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLLVFSITEHESFTATAEFREQILRVKAEEDKIPLLVVGNKSDLEERRQVPVEEARGKAEEWGVQYVETSAKTRANVDKVFFDLMREIRAKKMSENKDKNGRKSGKSKKSFKERCCLL", "length": 206 }, "evidence": [ { "id": "45925565", "url": "http://www.informatics.jax.org/homology/45925565", "database": "MGI" }, { "id": "P11234", "url": "https://omabrowser.org/oma/group/P11234/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9JIW9-1", "protein_name": "Ras-related protein Ral-B", "gene_name": "Ralb", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAANKGKSQGSLVLHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLLVFSITEHESFTATAEFREQILRVKSEEDKIPLLVVGNKSDLEERRQVPVDEARGKAEEWGVQYVETSAKTRANVDKVFFDLMREIRAKKMSENKDKNGRKSSKSKKSFKERCCLL", "length": 206 }, "evidence": [ { "id": "45925565", "url": "http://www.informatics.jax.org/homology/45925565", "database": "MGI" }, { "id": "P11234", "url": 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"database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" } ], "pmid": "" }, { "name": "negative regulation of protein binding", "id": "GO:0032091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032091", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" } ], "pmid": "" }, { "name": "Ras protein signal transduction", "id": "GO:0007265", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007265", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" } ], "pmid": "" }, { "name": "positive regulation of epidermal growth factor receptor signaling pathway", "id": "GO:0045742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045742", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" } ], "pmid": "" }, { "name": "positive regulation of protein serine/threonine kinase activity", "id": "GO:0071902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071902", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" } ], "pmid": "" }, { "name": "cell cycle", "id": "GO:0007049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007049", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" } ], "pmid": "" }, { "name": "cellular response to starvation", "id": "GO:0009267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009267", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" } ], "pmid": "" }, { "name": "regulation of exocyst assembly", "id": "GO:0001928", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001928", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" } ], "pmid": "" }, { "name": "regulation of exocyst localization", "id": "GO:0060178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060178", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" } ], "pmid": "" }, { "name": "positive regulation of autophagosome assembly", "id": "GO:2000786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000786", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Prenylation is essential for membrane localization. The geranylgeranylated form and the farnesylated mutant does not undergo alternative prenylation in response to geranylgeranyltransferase I inhibitors (GGTIs) and farnesyltransferase I inhibitors (FTIs).", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" }, { "database": "PubMed", "id": "17875936", "url": "https://glygen.org/publication/PubMed/17875936" } ] }, { "annotation": "The farnesylated form confers resistance to the proapoptotic and anti-anchorage-dependent growth effects of geranylgeranyltransferase I inhibitors, including GGTI-2417.", "evidence": [ { "database": "UniProtKB", "id": "P11234", "url": "https://www.uniprot.org/uniprot/P11234" }, { "database": "PubMed", "id": "17875936", "url": "https://glygen.org/publication/PubMed/17875936" } ] } ], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + H(+) + phosphate", "summary": "", "cellular_location": "", 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"id": "F1M2G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M2G3" } ] } ] }, { "uniprot_ac": "M0RC99", "gene_name": "Rab5a", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "M0RC99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RC99" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "M0RC99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RC99" } ] } ] }, { "uniprot_ac": "O00194", "gene_name": "RAB27B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "O00194", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00194" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "O00194", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00194" } ] } ] }, { "uniprot_ac": "O00429", "gene_name": "DNM1L", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "O00429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00429" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "O00429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00429" } ] } ] }, { "uniprot_ac": "O00909", "gene_name": "arfA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "O00909", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00909" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "O00909", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00909" } ] } ] }, { "uniprot_ac": "O08989", "gene_name": "Mras", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "O08989", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08989" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "O08989", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08989" } ] } ] }, { "uniprot_ac": "O14807", "gene_name": "MRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "O14807", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14807" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "O14807", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14807" } ] } ] }, { "uniprot_ac": "O18333", "gene_name": "Rab2", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "O18333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18333" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "O18333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18333" } ] } ] }, { "uniprot_ac": "O18412", "gene_name": "fzo", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "O18412", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18412" } ] } ] }, { "uniprot_ac": "O35303", "gene_name": "Dnm1l", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "O35303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35303" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "O35303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35303" } ] } ] }, { "uniprot_ac": "O35509", "gene_name": "Rab11b", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "O35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35509" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "O35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35509" } ] } ] }, { "uniprot_ac": "O60313", "gene_name": "OPA1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "O60313", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60313" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "O60313", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60313" } ] } ] }, { "uniprot_ac": "O60841", "gene_name": "EIF5B", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "O60841", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60841" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "O60841", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60841" } ] } ] }, { "uniprot_ac": "O76742", "gene_name": "Rab7", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "O76742", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76742" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "O76742", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76742" } ] } ] }, { "uniprot_ac": "O94811", "gene_name": "TPPP", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "O94811", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94811" } ] } ] }, { "uniprot_ac": "O95140", "gene_name": "MFN2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "O95140", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95140" } ] } ] }, { "uniprot_ac": "P01111", "gene_name": "NRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P01111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P01111" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P01111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P01111" } ] } ] }, { "uniprot_ac": "P01112", "gene_name": "HRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P01112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P01112" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P01112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P01112" } ] } ] }, { "uniprot_ac": "P01116", "gene_name": "KRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P01116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P01116" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P01116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P01116" } ] } ] }, { "uniprot_ac": "P01119", "gene_name": "RAS1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P01119", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P01119" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P01119", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P01119" } ] } ] }, { "uniprot_ac": "P01120", "gene_name": "RAS2", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P01120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P01120" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P01120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P01120" } ] } ] }, { "uniprot_ac": "P03967", "gene_name": "rasD", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P03967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03967" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P03967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03967" } ] } ] }, { "uniprot_ac": "P04388", "gene_name": "Ras64B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P04388", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04388" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P04388", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04388" } ] } ] }, { "uniprot_ac": "P05197", "gene_name": "Eef2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P05197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05197" } ] } ] }, { "uniprot_ac": "P05213", "gene_name": "Tuba1b", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P05213", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05213" } ] } ] }, { "uniprot_ac": "P05214", "gene_name": "Tuba3a", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P05214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05214" } ] } ] }, { "uniprot_ac": "P05453", "gene_name": "SUP35", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P05453", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05453" } ] } ] }, { "uniprot_ac": "P05712", "gene_name": "Rab2a", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P05712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05712" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P05712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05712" } ] } ] }, { "uniprot_ac": "P05714", "gene_name": "Rab4a", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P05714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05714" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P05714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05714" } ] } ] }, { "uniprot_ac": "P06603", "gene_name": "alphaTub84B", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P06603", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06603" } ] } ] }, { "uniprot_ac": "P06604", "gene_name": "alphaTub85E", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P06604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06604" } ] } ] }, { "uniprot_ac": "P06605", "gene_name": "alphaTub84D", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P06605", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06605" } ] } ] }, { "uniprot_ac": "P06606", "gene_name": "alphaTub67C", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P06606", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06606" } ] } ] }, { "uniprot_ac": "P06780", "gene_name": "RHO1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P06780", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06780" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P06780", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06780" } ] } ] }, { "uniprot_ac": "P06781", "gene_name": "RHO2", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P06781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06781" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P06781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06781" } ] } ] }, { "uniprot_ac": "P08556", "gene_name": "Nras", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P08556", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08556" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P08556", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08556" } ] } ] }, { "uniprot_ac": "P08644", "gene_name": "Kras", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P08644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08644" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P08644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08644" } ] } ] }, { "uniprot_ac": "P08645", "gene_name": "Rap1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P08645", "database": "UniProtKB", "url": 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"id": "P60763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60763" } ] } ] }, { "uniprot_ac": "P60764", "gene_name": "Rac3", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P60764", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60764" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P60764", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60764" } ] } ] }, { "uniprot_ac": "P60766", "gene_name": "Cdc42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P60766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60766" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P60766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60766" } ] } ] }, { "uniprot_ac": "P60953", "gene_name": "CDC42", "activity": [ { "ec_number": 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"activity": "", "evidence": [ { "id": "P61019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61019" } ] } ] }, { "uniprot_ac": "P61020", "gene_name": "RAB5B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61020", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61020" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61020", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61020" } ] } ] }, { "uniprot_ac": "P61021", "gene_name": "Rab5b", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61021" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61021" } ] } ] }, { "uniprot_ac": "P61026", "gene_name": "RAB10", 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"url": "https://www.uniprot.org/uniprot/P61224" } ] } ] }, { "uniprot_ac": "P61225", "gene_name": "RAP2B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61225", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61225" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61225", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61225" } ] } ] }, { "uniprot_ac": "P61226", "gene_name": "Rap2b", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61226", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61226" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61226", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61226" } ] } ] }, { "uniprot_ac": "P61227", "gene_name": "Rap2b", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) 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