{ "uniprot_canonical_ac": "P11233-1", "uniprot_ac": "P11233", "uniprot_id": "RALA_HUMAN", "mass": { "chemical_mass": 23567.0, "monoisotopic_mass": 23567.0 }, "refseq": { "ac": "NP_005393", "name": "ras-related protein Ral-A precursor", "summary": "The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005393" }, "gene_names": [ { "name": "RALA", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P11233", "id": "P11233" }, { "name": "HINCONS; RAL", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005393", "id": "NP_005393" }, { "name": "RALA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005393", "id": "NP_005393" }, { "name": "RAL", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P11233", "id": "P11233" } ], "protein_names": [ { "name": "Ras-related protein Ral-A", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P11233" }, { "name": "3.6.5.2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P11233" }, { "name": "Ras-related protein Ral-A; RAS-like protein A; ras related GTP binding protein A; Ras family small GTP binding protein RALA; v-ral simian leukemia viral oncogene homolog A (ras related); RALA Ras like proto-oncogene A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005393", "id": "NP_005393" }, { "name": "ras-related protein Ral-A precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005393", "id": "NP_005393" } ], "function": [ { "annotation": "Dysregulation of RalA signaling through dual regulatory mechanisms exerts its oncogenic functions in hepatocellular carcinoma.", "evidence": [ { "database": "RefSeq", "id": "NP_005393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005393" }, { "database": "PubMed", "id": "34767674", "url": "https://glygen.org/publication/PubMed/34767674" } ] }, { "annotation": "Identification of RALA as a Therapeutic Target and Prognostic Predictor of Osteosarcoma. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_005393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005393" }, { "database": "PubMed", "id": "36817861", "url": "https://glygen.org/publication/PubMed/36817861" } ] }, { "annotation": "Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors (PubMed:18756269, PubMed:19306925, PubMed:20005108, PubMed:21822277, PubMed:30500825). Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (PubMed:20005108). Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (PubMed:19306925). During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (PubMed:18756269). During mitosis, also controls mitochondrial fission by recruiting to the mitochondrion RALBP1, which mediates the phosphorylation and activation of DNM1L by the mitotic kinase cyclin B-CDK1 (PubMed:21822277).", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233#function" }, { "database": "PubMed", "id": "20005108", "url": "https://glygen.org/publication/PubMed/20005108" }, { "database": "PubMed", "id": "19306925", "url": "https://glygen.org/publication/PubMed/19306925" }, { "database": "PubMed", "id": "18756269", "url": "https://glygen.org/publication/PubMed/18756269" }, { "database": "PubMed", "id": "21822277", "url": "https://glygen.org/publication/PubMed/21822277" }, { "database": "PubMed", "id": "30500825", "url": "https://glygen.org/publication/PubMed/30500825" } ] }, { "annotation": "Ral GTPase promotes metastasis of pancreatic ductal adenocarcinoma via elevation of TGF-beta1 production.", "evidence": [ { "database": "RefSeq", "id": "NP_005393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005393" }, { "database": "PubMed", "id": "37116704", "url": "https://glygen.org/publication/PubMed/37116704" } ] }, { "annotation": "RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal.", "evidence": [ { "database": "RefSeq", "id": "NP_005393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005393" }, { "database": "PubMed", "id": "34320341", "url": "https://glygen.org/publication/PubMed/34320341" } ] }, { "annotation": "The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_005393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005393" } ] } ], "disease": [ { "disease_id": "MONDO:0859142", "recommended_name": { "id": "MONDO:0859142", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0859142", "name": "Hiatt-Neu-Cooper neurodevelopmental syndrome", "description": "" }, "synonyms": [ { "id": "MIM:619311", "resource": "MIM", "url": "https://www.omim.org/entry/619311", "name": "Hiatt-Neu-Cooper neurodevelopmental syndrome", "description": "Hiatt-Neu-Cooper neurodevelopmental syndrome" } ], "evidence": [ { "id": "619311", "database": "MIM", "url": "https://www.omim.org/entry/619311" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 194, "end_pos": 194, "sequence_org": "S", "sequence_mut": "A", "comment": "Decreased localization to mitochondrion. Loss of function in mitochondrial fission.", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" }, { "database": "PubMed", "id": "21822277", "url": "https://glygen.org/publication/PubMed/21822277" } ] }, { "start_pos": 194, "end_pos": 194, "sequence_org": "S", "sequence_mut": "D", "comment": "Increased localization to mitochondrion.", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" }, { "database": "PubMed", "id": "21822277", "url": "https://glygen.org/publication/PubMed/21822277" } ] }, { "start_pos": 1, "end_pos": 11, "sequence_org": "MAANKPKGQNS", "sequence_mut": "", "comment": "Impaired cytokinesis, as shown by increased number of binucleate cells. Impaired cytokinesis; when associated with L-72.", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" }, { "database": "PubMed", "id": "18756269", "url": "https://glygen.org/publication/PubMed/18756269" } ] }, { "start_pos": 203, "end_pos": 203, "sequence_org": "C", "sequence_mut": "S", "comment": "Loss of geranylgeranylation and membrane localization.", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" }, { "database": "PubMed", "id": "17875936", "url": "https://glygen.org/publication/PubMed/17875936" } ] }, { "start_pos": 206, "end_pos": 206, "sequence_org": "L", "sequence_mut": "S", "comment": "Converts geranyl-geranylation to farnesylation. No effect on membrane localization. Fails to deflect GGTI-induced apoptosis of adherent cell cultures, but rescues anchorage-independent cell proliferation.", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" }, { "database": "PubMed", "id": "17875936", "url": "https://glygen.org/publication/PubMed/17875936" } ] }, { "start_pos": 23, "end_pos": 23, "sequence_org": "G", "sequence_mut": "V", "comment": "Impaired cytokinesis, as shown by increased number of binucleate cells. No effect on interaction with EXOC2 and EXOC8. No effect on cytokinesis; when associated with R-38 or W-48. Decreased interaction with EXOC2 and EXOC8; when associated with R-38 or W-48.", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" }, { "database": "PubMed", "id": "18756269", "url": "https://glygen.org/publication/PubMed/18756269" } ] }, { "start_pos": 38, "end_pos": 38, "sequence_org": "E", "sequence_mut": "R", "comment": "Impaired cytokinesis, as shown by increased number of binucleate cells. No effect on cytokinesis; when associated with V-23. Decreased interaction with EXOC2 and EXOC8; when associated with V-23.", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" }, { "database": "PubMed", "id": "18756269", "url": "https://glygen.org/publication/PubMed/18756269" } ] }, { "start_pos": 46, "end_pos": 46, "sequence_org": "T", "sequence_mut": "A", "comment": "Abolished monoglucosylation by P.sordellii toxin TcsL.", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" }, { "database": "PubMed", "id": "8858106", "url": "https://glygen.org/publication/PubMed/8858106" } ] }, { "start_pos": 47, "end_pos": 47, "sequence_org": "K", "sequence_mut": "E", "comment": "Strongly reduces interaction with EXOC8.", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" }, { "database": "PubMed", "id": "15920473", "url": "https://glygen.org/publication/PubMed/15920473" } ] }, { "start_pos": 47, "end_pos": 47, "sequence_org": "K", "sequence_mut": "I", "comment": "No effect on interaction with EXOC8.", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" }, { "database": "PubMed", "id": "15920473", "url": "https://glygen.org/publication/PubMed/15920473" } ] }, { "start_pos": 48, "end_pos": 48, "sequence_org": "A", "sequence_mut": "W", "comment": "Impaired cytokinesis, as shown by increased number of binucleate cells. No effect on cytokinesis; when associated with V-23. Decreased interaction with EXOC2 and EXOC8; when associated with V-23.", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" }, { "database": "PubMed", "id": "18756269", "url": "https://glygen.org/publication/PubMed/18756269" } ] }, { "start_pos": 48, "end_pos": 48, "sequence_org": "A", "sequence_mut": "W", "comment": "Strongly reduces interaction with EXOC8.", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" }, { "database": "PubMed", "id": "15920473", "url": "https://glygen.org/publication/PubMed/15920473" } ] }, { "start_pos": 49, "end_pos": 49, "sequence_org": "D", "sequence_mut": "E", "comment": "No effect on cytokinesis; when associated with L-72.", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" }, { "database": "PubMed", "id": "18756269", "url": "https://glygen.org/publication/PubMed/18756269" } ] }, { "start_pos": 49, "end_pos": 49, "sequence_org": "D", "sequence_mut": "N", "comment": "No effect on cytokinesis. Impaired cytokinesis, as shown by increased number of binucleate cells; when associated with L-72.", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" }, { "database": "PubMed", "id": "18756269", "url": "https://glygen.org/publication/PubMed/18756269" } ] }, { "start_pos": 50, "end_pos": 50, "sequence_org": "S", "sequence_mut": "W", "comment": "Strongly reduces interaction with EXOC8.", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" }, { "database": "PubMed", "id": "15920473", "url": "https://glygen.org/publication/PubMed/15920473" } ] }, { "start_pos": 52, "end_pos": 52, "sequence_org": "R", "sequence_mut": "A", "comment": "Strongly reduces interaction with EXOC8.", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" }, { "database": "PubMed", "id": "15920473", "url": "https://glygen.org/publication/PubMed/15920473" } ] }, { "start_pos": 52, "end_pos": 52, "sequence_org": "R", "sequence_mut": "W", "comment": "No effect on interaction with EXOC8.", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" }, { "database": "PubMed", "id": "15920473", "url": "https://glygen.org/publication/PubMed/15920473" } ] }, { "start_pos": 72, "end_pos": 72, "sequence_org": "Q", "sequence_mut": "L", "comment": "Impaired cytokinesis, as shown by increased number of binucleate cells. Impaired cytokinesis; when associated with N-49 or 1-M--S-11. No effect on cytokinesis; when associated with E-49.", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" }, { "database": "PubMed", "id": "18756269", "url": "https://glygen.org/publication/PubMed/18756269" } ] }, { "start_pos": 81, "end_pos": 81, "sequence_org": "N", "sequence_mut": "A", "comment": "No effect on interaction with EXOC8.", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" }, { "database": "PubMed", "id": "15920473", "url": "https://glygen.org/publication/PubMed/15920473" } ] }, { "start_pos": 81, "end_pos": 81, "sequence_org": "N", "sequence_mut": "R", "comment": "Strongly reduces interaction with EXOC8.", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" }, { "database": "PubMed", "id": "15920473", "url": "https://glygen.org/publication/PubMed/15920473" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "78.41", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000006451", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000006451" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "98.01", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000006451", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000006451" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "76.07", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000006451", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000006451" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "49.96", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000006451", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000006451" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "88.85", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000006451", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000006451" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "94.18", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000006451", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000006451" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "71.68", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000006451", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000006451" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "90.06", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000006451", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000006451" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "86.91", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000006451", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000006451" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "80.46", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000006451", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000006451" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "84.89", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000006451", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000006451" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "81.89", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000006451", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000006451" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "90.39", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000006451", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000006451" } ] } ], "expression_disease": [ { "significant": "No", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P11233", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11233" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", 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"MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P11233", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11233" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "P11233", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11233" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"categories": [ "3D Structure" ] }, { "id": "PF00071", "url": "http://pfam.xfam.org/family/PF00071", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P11233", "url": "https://pharos.nih.gov/targets/P11233", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_P11233", "url": "http://purl.obolibrary.org/obo/PR_P11233", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-1445148", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1445148", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-171007", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-171007", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-8950505", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8950505", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_005393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005393", "database": "RefSeq", 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"MAANKPKGQNSLALHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLCVFSITEMESFAATADFREQILRVKEDENVPFLLVGNKSDLEDKRQVSVEEAKNRAEQWNVNYVETSAKTRANVDKVFFDLMREIRARKMEDSKEKNGKKKRKSLAKRIRERCCIL", "length": 206, "header": "sp|P11233-1|RALA_HUMAN Isoform 1 of Ras-related protein Ral-A OS=Homo sapiens OX=9606 GN=RALA PE=1 SV=1 CANONICAL=P11233-1" }, "isoforms": [ { "isoform_ac": "C9JPE8-1", "url": "", "sequence": { "sequence": "MAANKPKGQNSLALHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLCVFSITEMESF", "length": 101, "header": "tr|C9JPE8-1|RALA_HUMAN Computationally mapped isoform of Ras-related protein Ral-A OS=Homo sapiens OX=9606 GN=RALA PE=1 SV=1 CANONICAL=P11233-1" }, "locus": { "chromosome": "7", "start_pos": 39690570, "end_pos": 39686668, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000436179.1", "url": "https://www.ensembl.org/id/ENST00000436179.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000388975.1", "url": "https://www.ensembl.org/id/ENSP00000388975.1" } ] } }, { "isoform_ac": "H7C3P7-1", "url": "", "sequence": { "sequence": "XGQNSLALHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLCVFSITEMESFAATADFREQILRVKEDENVPFLLVGNKSDLEDKRQVSVEEAKNRAEQWNVNYVETSAKTRANVDKSGPS", "length": 164, "header": "tr|H7C3P7-1|RALA_HUMAN Computationally mapped isoform of Ras-related protein Ral-A OS=Homo sapiens OX=9606 GN=RALA PE=1 SV=1 CANONICAL=P11233-1" }, "locus": { "chromosome": "7", "start_pos": 39697420, "end_pos": 39686687, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000434466.1", "url": "https://www.ensembl.org/id/ENST00000434466.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000413227.1", "url": "https://www.ensembl.org/id/ENSP00000413227.1" } ] } }, { "isoform_ac": "P11233-1", "url": "", "sequence": { "sequence": "MAANKPKGQNSLALHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLCVFSITEMESFAATADFREQILRVKEDENVPFLLVGNKSDLEDKRQVSVEEAKNRAEQWNVNYVETSAKTRANVDKVFFDLMREIRARKMEDSKEKNGKKKRKSLAKRIRERCCIL", "length": 206, "header": "sp|P11233-1|RALA_HUMAN Isoform 1 of Ras-related protein Ral-A OS=Homo sapiens OX=9606 GN=RALA PE=1 SV=1 CANONICAL=P11233-1" }, "locus": { "chromosome": "7", "start_pos": 39706242, "end_pos": 39686668, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000005257.7", "url": "https://www.ensembl.org/id/ENST00000005257.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000005257.2", "url": "https://www.ensembl.org/id/ENSP00000005257.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 11, "end_pos": 11, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P11233", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11233" }, { "database": "PubMed", "id": "17540176", "url": "https://glygen.org/publication/PubMed/17540176" } ], "site_lbl": "Ser11" }, { "start_pos": 183, "end_pos": 183, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P11233", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11233" }, { "database": "PubMed", "id": "17540176", "url": "https://glygen.org/publication/PubMed/17540176" }, { "database": "PubMed", "id": "30995277", "url": "https://glygen.org/publication/PubMed/30995277" } ], "site_lbl": "Ser183" }, { "start_pos": 194, "end_pos": 194, "kinase_uniprot_canonical_ac": "O14965-1", "kinase_gene_name": "AURKA", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P11233", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11233" }, { "database": "PubMed", "id": "15637052", "url": "https://glygen.org/publication/PubMed/15637052" } ], "site_lbl": "Ser194" }, { "start_pos": 194, "end_pos": 194, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by AURKA", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" }, { "database": "iPTMnet", "id": "P11233", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11233" }, { "database": "PubMed", "id": "19901077", "url": "https://glygen.org/publication/PubMed/19901077" }, { "database": "PubMed", "id": "21822277", "url": "https://glygen.org/publication/PubMed/21822277" }, { "database": "PubMed", "id": "24222664", "url": "https://glygen.org/publication/PubMed/24222664" }, { "database": "PubMed", "id": "30070631", "url": "https://glygen.org/publication/PubMed/30070631" }, { "database": "PubMed", "id": "30500825", "url": "https://glygen.org/publication/PubMed/30500825" }, { "database": "PubMed", "id": "30995277", "url": "https://glygen.org/publication/PubMed/30995277" } ], "site_lbl": "Ser194" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral.", "journal": "J. Biol. Chem.", "date": "2000", "authors": "Rebhun JF, Chen H, Quilliam LA", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "reference": [ { "type": "PubMed", "id": "10747847", "url": "https://glygen.org/publication/PubMed/10747847" } ] }, { "title": "Ral GTPases regulate exocyst assembly through dual subunit interactions.", "journal": "J. Biol. Chem.", "date": "2003", "authors": "Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "reference": [ { "type": "PubMed", "id": "14525976", "url": "https://glygen.org/publication/PubMed/14525976" } ] }, { "title": "Identification of V23RalA-Ser194 as a critical mediator for Aurora-A-induced cellular motility and transformation by small pool expression screening.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Wu JC, Chen TY, Yu CT, Tsai SJ, Hsu JM, Tang MJ, Chou CK, Lin WJ, Yuan CJ, Huang CY", "evidence": [ { "database": "iPTMnet", "id": "P11233", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11233" } ], "reference": [ { "type": "PubMed", "id": "15637052", "url": "https://glygen.org/publication/PubMed/15637052" } ] }, { "title": "Molecular recognition of an ADP-ribosylating Clostridium botulinum C3 exoenzyme by RalA GTPase.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2005", "authors": "Holbourn KP, Sutton JM, Evans HR, Shone CC, Acharya KR", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "reference": [ { "type": "PubMed", "id": "15809419", "url": "https://glygen.org/publication/PubMed/15809419" } ] }, { "title": "Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects.", "journal": "Diabetes", "date": "2005", "authors": "Karlsson HK, Zierath JR, Kane S, Krook A, Lienhard GE, Wallberg-Henriksson H", "evidence": [ { "database": "Reactome", "id": "R-HSA-1445148", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1445148" } ], "reference": [ { "type": "PubMed", "id": "15919790", "url": "https://glygen.org/publication/PubMed/15919790" } ] }, { "title": "Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase.", "journal": "The EMBO journal", "date": "2005", "authors": "Jin R, Junutula JR, Matern HT, Ervin KE, Scheller RH, Brunger AT", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "reference": [ { "type": "PubMed", "id": "15920473", "url": "https://glygen.org/publication/PubMed/15920473" } ] }, { "title": "AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain.", "journal": "The Biochemical journal", "date": "2005", "authors": "Miinea CP, Sano H, Kane S, Sano E, Fukuda M, Peranen J, Lane WS, Lienhard GE", "evidence": [ { "database": "Reactome", "id": "R-HSA-1445148", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1445148" } ], "reference": [ { "type": "PubMed", "id": "15971998", "url": "https://glygen.org/publication/PubMed/15971998" } ] }, { "title": "Proteome profiling of interleukin-12 treated human T helper cells.", "journal": "Proteomics", "date": "2005", "authors": "Rosengren AT, Nyman TA, Lahesmaa R", "evidence": [ { "database": "Reactome", "id": "R-HSA-8950505", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8950505" } ], "reference": [ { "type": "PubMed", "id": "16038020", "url": "https://glygen.org/publication/PubMed/16038020" } ] }, { "title": "Crystal structure of the C3bot-RalA complex reveals a novel type of action of a bacterial exoenzyme.", "journal": "EMBO J.", "date": "2005", "authors": "Pautsch A, Vogelsgesang M, Trankle J, Herrmann C, Aktories K", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "reference": [ { "type": "PubMed", "id": "16177825", "url": "https://glygen.org/publication/PubMed/16177825" } ] }, { "title": "Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission.", "journal": "Cell", "date": "2005", "authors": "Gromley Adam, Yeaman Charles, Rosa Jack, Redick Sambra, Chen Chun-Ting, Mirabelle Stephanie, Guha Minakshi, Sillibourne James, Doxsey Stephen J", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "reference": [ { "type": "PubMed", "id": "16213214", "url": "https://glygen.org/publication/PubMed/16213214" } ] }, { "title": "A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Ramm G, Larance M, Guilhaus M, James DE", "evidence": [ { "database": "Reactome", "id": "R-HSA-1445148", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1445148" } ], "reference": [ { "type": "PubMed", "id": "16880201", "url": "https://glygen.org/publication/PubMed/16880201" } ] }, { "title": "Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle.", "journal": "Diabetes", "date": "2007", "authors": "Howlett KF, Sakamoto K, Garnham A, Cameron-Smith D, Hargreaves M", "evidence": [ { "database": 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Cox AD, Counter CM", "evidence": [ { "database": "iPTMnet", "id": "P11233", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11233" } ], "reference": [ { "type": "PubMed", "id": "19901077", "url": "https://glygen.org/publication/PubMed/19901077" } ] }, { "title": "RalA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling.", "journal": "Current biology : CB", "date": "2010-01-12", "authors": "Balasubramanian Nagaraj, Meier Jeremy A, Scott David W, Norambuena Andr\u00e9s, White Michael A, Schwartz Martin Alexander", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "reference": [ { "type": "PubMed", "id": "20005108", "url": "https://glygen.org/publication/PubMed/20005108" } ] }, { "title": "Interaction of retinitis pigmentosa GTPase regulator (RPGR) with RAB8A GTPase: implications for cilia dysfunction and photoreceptor degeneration.", "journal": "Human molecular genetics", "date": "2010", "authors": "Murga-Zamalloa CA, Atkins SJ, Peranen J, Swaroop A, Khanna H", "evidence": [ { "database": "Reactome", "id": "R-HSA-1445148", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1445148" } ], "reference": [ { "type": "PubMed", "id": "20631154", "url": "https://glygen.org/publication/PubMed/20631154" } ] }, { "title": "Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle.", "journal": "The Biochemical journal", "date": "2010", "authors": "Vichaiwong K, Purohit S, An D, Toyoda T, Jessen N, Hirshman MF, Goodyear LJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-1445148", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1445148" } ], "reference": [ { "type": "PubMed", "id": "20701589", "url": "https://glygen.org/publication/PubMed/20701589" } ] }, { "title": "Exercise-induced TBC1D1 Ser237 phosphorylation and 14-3-3 protein binding capacity in human skeletal muscle.", "journal": "The Journal of physiology", "date": "2010", "authors": "Frosig C, Pehmoller C, Birk JB, Richter EA, Wojtaszewski JF", "evidence": [ { "database": "Reactome", "id": "R-HSA-1445148", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1445148" } ], "reference": [ { "type": "PubMed", "id": "20837646", "url": "https://glygen.org/publication/PubMed/20837646" } ] }, { "title": "Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.", "journal": "The Journal of cell biology", "date": "2010", "authors": "Yoshimura S, Gerondopoulos A, Linford A, Rigden DJ, Barr FA", "evidence": [ { "database": "Reactome", "id": "R-HSA-1445148", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1445148" } ], "reference": [ { "type": "PubMed", "id": "20937701", "url": "https://glygen.org/publication/PubMed/20937701" } ] }, { "title": "Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Park SY, Jin W, Woo JR, Shoelson SE", "evidence": [ { "database": "Reactome", "id": "R-HSA-1445148", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1445148" } ], "reference": [ { "type": "PubMed", "id": "21454505", "url": "https://glygen.org/publication/PubMed/21454505" } ] }, { "title": "AS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membrane.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Koumanov F, Richardson JD, Murrow BA, Holman GD", "evidence": [ { "database": "Reactome", "id": "R-HSA-1445148", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1445148" } ], "reference": [ { "type": "PubMed", "id": "21454690", "url": "https://glygen.org/publication/PubMed/21454690" } ] }, { "title": "RALA and RALBP1 regulate mitochondrial fission at mitosis.", "journal": "Nature cell biology", "date": "2011", "authors": "Kashatus DF, Lim 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cancer is not dependent on RalA phosphorylation.", "journal": "Molecular cancer therapeutics", "date": "2014", "authors": "Neel NF, Stratford JK, Shinde V, Ecsedy JA, Martin TD, Der CJ, Yeh JJ", "evidence": [ { "database": "iPTMnet", "id": "P11233", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P11233" } ], "reference": [ { "type": "PubMed", "id": "24222664", "url": "https://glygen.org/publication/PubMed/24222664" } ] }, { "title": "Identification of the ral and rac1 gene products, low molecular mass GTP-binding proteins from human platelets.", "journal": "J. Biol. Chem.", "date": "1989", "authors": "Polakis PG, Weber RF, Nevins B, Didsbury JR, Evans T, Snyderman R", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" }, { "database": "Reactome", "id": "R-HSA-1445148", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1445148" } ], "reference": [ { "type": "PubMed", "id": "2550440", "url": "https://glygen.org/publication/PubMed/2550440" } ] }, { "title": "Coding sequences of human ralA and ralB cDNAs.", "journal": "Nucleic Acids Res.", "date": "1989", "authors": "Chardin P, Tavitian A", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "reference": [ { "type": "PubMed", "id": "2662142", "url": "https://glygen.org/publication/PubMed/2662142" } ] }, { "title": "Aurora kinase A localises to mitochondria to control organelle dynamics and energy production.", "journal": "eLife", "date": "2018-08-02", "authors": "Bertolin Giulia, 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"date": "2022", "authors": "Tian L, Zhao L, Sze KM, Kam CS, Ming VS, Wang X, Zhang VX, Ho DW, Cheung TT, Chan LK, Ng IO", "evidence": [ { "database": "RefSeq", "id": "NP_005393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005393" } ], "reference": [ { "type": "PubMed", "id": "34767674", "url": "https://glygen.org/publication/PubMed/34767674" } ] }, { "title": "Identification of RALA as a Therapeutic Target and Prognostic Predictor of Osteosarcoma.", "journal": "BioMed research international", "date": "2023", "authors": "Fan Gentao, Zhu Yan, Zhu Hao, Yu Lingfeng, Wang Zhen, Zhai Chenjun, Zhou Guangxin, Zhao Jianning, Wang Yicun", "evidence": [ { "database": "RefSeq", "id": "NP_005393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005393" } ], "reference": [ { "type": "PubMed", "id": "36817861", "url": "https://glygen.org/publication/PubMed/36817861" } ] }, { "title": "Ral GTPase promotes metastasis of pancreatic ductal adenocarcinoma via elevation of TGF-\u03b21 production.", 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"database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "myosin binding", "id": "GO:0017022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017022", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "Edg-2 lysophosphatidic acid receptor binding", "id": "GO:0031755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031755", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "GDP binding", "id": "GO:0019003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019003", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 16, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "membrane raft localization", "id": "GO:0051665", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051665", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "chemotaxis", "id": "GO:0006935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006935", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "receptor internalization", "id": "GO:0031623", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031623", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "regulation of actin cytoskeleton organization", "id": "GO:0032956", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032956", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "Ras protein signal transduction", "id": "GO:0007265", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007265", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "neural tube closure", "id": "GO:0001843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001843", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "positive regulation of epidermal growth factor receptor signaling pathway", "id": "GO:0045742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045742", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "cell cycle", "id": "GO:0007049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007049", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "exocytosis", "id": "GO:0006887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "positive regulation of filopodium assembly", "id": "GO:0051491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051491", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "establishment of protein localization to mitochondrion", "id": "GO:0072655", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072655", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "positive regulation of mitochondrial fission", "id": "GO:0090141", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090141", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "regulation of exocytosis", "id": "GO:0017157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017157", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "regulation of postsynaptic neurotransmitter receptor internalization", "id": "GO:0099149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099149", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 11, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "cytoplasmic vesicle membrane", "id": "GO:0030659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "cleavage furrow", "id": "GO:0032154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032154", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "synaptic membrane", "id": "GO:0097060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097060", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "Flemming body", "id": "GO:0090543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090543", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" }, { "name": "Schaffer collateral - CA1 synapse", "id": "GO:0098685", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098685", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "(Microbial infection) Glucosylated at Thr-46 by P.sordellii toxin TcsL from strain 6018 (PubMed:8858106). Monoglucosylation completely prevents the recognition of the downstream effector, blocking the GTPases in their inactive form (PubMed:8858106). Not glucosylated by TcsL from strain VPI 9048 (PubMed:8858106).", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" }, { "database": "PubMed", "id": "8858106", "url": "https://glygen.org/publication/PubMed/8858106" } ] }, { "annotation": "Phosphorylated. Phosphorylation at Ser-194 by AURKA/Aurora kinase A, during mitosis, induces RALA localization to the mitochondrion where it regulates mitochondrial fission.", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" }, { "database": "PubMed", "id": "21822277", "url": "https://glygen.org/publication/PubMed/21822277" } ] }, { "annotation": "Prenylation is essential for membrane localization. The geranylgeranylated form and the farnesylated mutant do not undergo alternative prenylation in response to geranylgeranyltransferase I inhibitors (GGTIs) and farnesyltransferase I inhibitors (FTIs).", "evidence": [ { "database": "UniProtKB", "id": "P11233", "url": "https://www.uniprot.org/uniprot/P11233" }, { "database": "PubMed", "id": "17875936", "url": "https://glygen.org/publication/PubMed/17875936" }, { "database": "PubMed", "id": "1903399", "url": "https://glygen.org/publication/PubMed/1903399" } ] } ], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + H(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08877-1", "Q6AYC2-1", "Q2TA68-1", "P61589-1", "Q6RUV5-1", "P23640-1", "O35303-1", "P21575-1", "P39052-1", "Q6AYF9-1", "Q8CFN2-1", "Q63663-1", "M0RC99-1", "Q99P74-1", "B2GUV7-1", "Q8R4Z9-1", "Q8R500-1", "D3ZQL7-1", "P97538-1", "Q6IMA3-1", "Q5BJQ5-1", "Q62636-1", "Q63486-1", "Q63487-1", "P61227-1", "P62836-1", "P63322-1", "Q04970-1", "P08644-1", "D3Z8L7-1", "P35281-1", "P36860-1", "Q6IMA7-1", "C9WPN6-1", "P20171-1", "P81795-1", "Q6AYZ1-1", "Q6AY56-1", "Q99MB4-1", "Q5XIF6-1", "P84079-1", "P68370-1", "Q68FR8-1", "Q6P9V9-1", "P51146-1", "O35509-1", "P62494-1", "Q6NYB7-1", "Q66HA6-1", "P09527-1", "P10536-1", "P05714-1", "Q8K586-1", "P62828-1", "P62332-1", "P35280-1", "P05712-1", "Q6AYB5-1", "Q6AXM7-1", "P05197-1", "P62630-1", "D3ZM99-1", "D3ZLK2-1", "Q5BJP6-1", "F1M2G3-1", "A0A8I5ZU96-1", "A0A8I6AHV4-1", "Q62639-1", "P97687-1", "P60953-2", "Q9UQ16-1", "P55039-1", "Q9Y295-1", "O00429-1", "Q05193-1", "P50570-1", "Q6NXR0-1", "Q96PP8-1", "P32455-1", "Q9H0R5-1", "Q96PP9-1", "P32456-1", "Q8N442-1", "O60841-1", "Q8IWA4-1", "O95140-1", "O60313-1", "Q8IVH4-1", "Q5S007-1", "O00194-1", "P51159-1", "P63000-1", "P20339-1", "P61586-1", "O94811-1", "P61018-1", "Q9H0U4-1", "P51148-1", "P51149-1", "Q9Y227-1", "P62820-1", "Q9NQZ7-1", "P20338-1", "P62491-1", "Q15907-1", "Q92928-1", "P61020-1", "Q9NVJ2-1", "A6NIZ1-1", "P61224-1", "A1A4Y4-1", "P61011-1", "P62834-1", "P11234-1", "Q2VIR3-1", "P41091-1", "P01112-1", "P61225-1", "Q9Y3L5-1", "Q96S79-1", "Q9NQL2-1", "Q9HB90-1", "Q9H628-1", "O14807-1", "P01116-1", "P60763-1", "P11233-1", "P01111-1", "Q99578-1", "Q96A58-1", "Q92737-1", "Q9BPW5-1", "Q7Z444-1", "P10114-1", "Q5VZM2-1", "P10301-1", "P62070-1", "Q6T310-1", "P61026-1", "Q92963-1", "Q7L523-1", "Q9NYN1-1", "P62826-1", "P62330-1", "Q8N8V2-1", "Q9NRW1-1", "Q6ZN66-1", "Q8WUD1-1", "P61006-1", "P61019-1", "Q9BSD7-1", "Q9NY65-1", "Q9H853-1", "P68366-1", "Q4V339-1", "Q8IUF1-1", "Q71U36-1", "Q9BQE3-1", "P68363-1", "Q5RIA9-1", "Q9BRT8-1", "A6NHL2-1", "Q5JTY5-1", "P84077-1", "Q6PEY2-1", "P13639-1", "P15170-1", "P0DPH7-1", "P0DPH8-1", "Q969S9-1", "Q15382-1", "P49961-1", "Q8IYD1-1", "P68104-1", "P61221-1", "Q9Y450-1", "P61021-1", "Q62293-1", "Q61107-1", "P60766-2", "Q8BZ98-1", "Q8CFB4-1", "P32233-1", "Q9QXB9-1", "Q01514-1", "Q8K1M6-1", "P39053-1", "P39054-1", "Q8C262-1", "Q5S006-1", "Q8C3X4-1", "Q9Z0E6-1", "Q9QZ85-1", "Q05D44-1", "P58281-1", "Q8C7H1-1", "Q80U63-1", "Q811U4-1", "Q99P58-1", "Q9QUI0-1", "Q9ERI2-1", "P63001-1", "Q3T9E4-1", "Q7TQD2-1", "Q9CQD1-1", "Q9CQW2-1", "P56371-1", "P62821-1", "P62492-1", "Q91ZR1-1", "P35278-1", "P46638-1", "P51150-1", "Q3TCT4-1", "Q9D1G1-1", "P61226-1", "P61027-1", "P62071-1", "Q99JI6-1", "Q8R367-1", "Q922H7-1", "Q8BU31-1", "Q80ZJ1-1", "Q80X95-1", "O08989-1", "P70426-1", "Q8K5A4-1", "P10833-1", "P70425-1", "Q61411-1", "Q5SSG5-1", "Q7TT45-1", "Q6NTA4-1", "Q99K70-1", "Q9JIW9-1", "Q08AT1-1", "P60764-1", "P62835-1", "P63321-1", "Q6IMB1-1", "P32883-1", "Q9Z0N2-1", "Q9Z0N1-1", "P08556-1", "Q7TN89-1", "A4UUI3-1", "Q8VEH6-1", "A0A0G2JDV3-1", "P68368-1", "Q91Z40-1", "Q60766-1", "A0A140LIF8-1", "Q9DCE9-1", "Q3UX10-1", "Q9JJZ2-1", "Q0GUM3-1", "E9PXC0-1", "P62331-1", "Q9CQA9-1", "P53994-1", "P59279-1", "P62827-1", "P68369-1", "P55258-1", "P61294-1", "Q61820-1", "P05214-1", "P84078-1", "Q69ZS7-1", "P05213-1", "P68373-1", "Q149F3-1", "Q8R050-1", "P14576-1", "Q921J2-1", "P55772-1", "Q8R2Q4-1", "B2RVE2-1", "P10126-1", "P61222-1", "P58252-1", "P13856-1", "P20606-1", "P01119-1", "P01120-1", "P05453-1", "P06780-1", "P06781-1", "P09733-1", "P09734-1", "P11076-1", "P19073-1", "P32324-1", "P32481-1", "P32769-1", "P53893-1", "P54861-1", "Q00246-1", "P39730-1", "P46943-1", "P38297-1", "P53729-1", "P20424-1", "P53290-1", "Q00582-1", "Q54Y30-1", "Q54XP6-1", "Q54XD8-1", "Q55CA9-1", "Q55CB0-1", "Q55CB7-1", "Q55CB8-1", "Q55CB9-1", "Q55CC0-1", "Q75K18-1", "Q869Q0-1", "Q86L51-1", "B0G189-1", "O00909-1", "P03967-1", "P0CT31-1", "P15064-1", "P15112-1", "P18613-1", "P32252-1", "P32253-1", "P32254-1", "P32255-1", "P36409-1", "P36411-1", "Q54MH8-1", "Q55AX0-1", "Q55BW0-1", "Q55F94-1", "P08645-1", "P08646-1", "P40793-1", "Q24208-1", "P04388-1", "P27619-1", "Q7YU24-1", "P48555-1", "Q9VRH6-1", "A1Z9N0-1", "O18412-1", "P06604-1", "P06606-1", "P61209-1", "P06603-1", "P06605-1", "Q9W074-1", "O18333-1", "Q9V3I2-1", "Q9VRY2-1", "O76742-1", "P13060-1", "Q9VM20-1" ], "evidence": [ { "id": "19669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19669" } ] }, { "id": "R-HSA-1458485", "name": "RALA hydrolyzes GTP", "equation": "", "summary": "RALA is a guanine nucleotide binding protein that hydrolyzes bound GTP to yield GDP and phosphate. RGC1 and RGC2 are GAPs (GTPase-activating proteins) that activate the GTPase activity of RALA. Insulin activates AKT, which phosphorylates RGC2, inactivating the GAP activity of RGC1:RGC2 and allowing RALA:GTP to accumulate.", "cellular_location": "cytoplasmic vesicle membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11233-1" ], "evidence": [ { "id": "R-HSA-1458485", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1458485" } ] }, { "id": "R-HSA-170991", "name": "SRC-1 autophosphorylates", "equation": "", "summary": "The active form of RAL, RAL-GTP, induces a conformational change in SRC-1, which autophosphorylates at tyrosine 419, thereby activating itself.", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [ "R-HSA-65043" ], "output_participant_list": [ "R-HSA-112331" ], "enzyme_list": [ "P11233-1", "P11234-1" ], "evidence": [ { "id": "R-HSA-170991", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-170991" } ] }, { "id": "R-HSA-171026", "name": "Guanine nucleotide exchange on RAL", "equation": "", "summary": "The Ras-related protein, RAL becomes activated once GDP is replaced by GTP.", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P01111-1", "P11233-1", "P01112-1", "P11234-1" ], "evidence": [ { "id": "R-HSA-171026", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-171026" } ] }, { "id": "R-HSA-2255342", "name": "RALA exchanges GDP for GTP", "equation": "", "summary": "RALA releases GDP and binds GTP, producing the active form of RALA. The reaction is accelerated by guanine nucleotide exchange factors (GEFs) and opposed by GTPase-activating proteins (GAPs) which enhance the conversion of RALA:GTP back to RALA:GDP by activating the GTPase activity of RALA.", "cellular_location": "cytoplasmic vesicle membrane", "input_participant_list": [ "R-ALL-1996291" ], "output_participant_list": [ "R-ALL-1996292" ], "enzyme_list": [ "P11233-1" ], "evidence": [ { "id": "R-HSA-2255342", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2255342" } ] }, { "id": "R-HSA-2316349", "name": "RALA:GTP binds MYO1C:CALM1 and activates MYO1C", "equation": "", "summary": "As inferred from mouse, insulin causes phosphorylation and inactivation of the Ral GTPase activating complex RGC, causing RALA:GTP to accumulate and associate with the unconventional myosin MYO1C. MYO1C, with calmodulin as a light chain, motors across cortical actin and interacts with the exocyst complex to tether vesicles at the plasma membrane (Chen et al. 2007).", "cellular_location": "cytoplasmic vesicle membrane, cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P60709-1", "P11233-1", "P63261-1" ], "evidence": [ { "id": "R-HSA-2316349", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2316349" } ] }, { "id": "R-HSA-2316352", "name": "SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane", "equation": "", "summary": "As inferred from mouse, GLUT4 (SLC2A4) initially translocates from endosomes to insulin-responsive vesicles (IRVs, GSVs). RAB11 appears to play a role in this process. IRVs bearing GLUT4 are then translocated across the cortical actin network to the plasma membrane. Unconventional myosin 5A (MYO5A) interacts with RAB10 or RAB8A on the vesicle and participates in transport of the IRV. Myosin 1C appears to act close to the plasma membrane and may facilitate fusion of the vesicle with the plasma membrane. RAB:GTP complexes coupled to the vesicles may interact with myosins to regulate their activity. Non-muscle myosin IIA (MYH9) appears to interact with the SNAP23 complex to dock the IRV at the inner membrane face.", "cellular_location": "cytoplasmic vesicle membrane, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P62491-1", "P60709-1", "P11233-1", "P63261-1", "P63000-1", "P61006-1", "P61026-1" ], "evidence": [ { "id": "R-HSA-2316352", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2316352" } ] }, { "id": "R-HSA-8950533", "name": "Expression of Ras-related protein Ral-A", "equation": "", "summary": "Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). 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"activity": "", "evidence": [ { "id": "P20171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20171" } ] } ] }, { "uniprot_ac": "P20338", "gene_name": "RAB4A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P20338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20338" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P20338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20338" } ] } ] }, { "uniprot_ac": "P20339", "gene_name": "RAB5A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P20339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20339" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P20339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20339" } ] } ] }, { "uniprot_ac": "P20424", "gene_name": "SRP54", "activity": [ { "ec_number": "3.6.5.4", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P20424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20424" } ] }, { "ec_number": "3.6.5.4", "activity": "", "evidence": [ { "id": "P20424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20424" } ] } ] }, { "uniprot_ac": "P20606", "gene_name": "SAR1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P20606", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20606" } ] } ] }, { "uniprot_ac": "P21575", "gene_name": "Dnm1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P21575", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21575" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "P21575", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21575" } ] } ] }, { 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