{
"uniprot_canonical_ac": "P11021-1",
"uniprot_ac": "P11021",
"uniprot_id": "BIP_HUMAN",
"mass": {
"chemical_mass": 72333.0,
"monoisotopic_mass": 72333.0
},
"refseq": {
"ac": "NP_005338",
"name": "endoplasmic reticulum chaperone BiP precursor",
"summary": "The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers. [provided by RefSeq, Jul 2020].",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_005338"
},
"gene_names": [
{
"name": "HSPA5",
"resource": "UniProtKB",
"type": "recommended",
"url": "https://www.uniprot.org/uniprot/P11021",
"id": "P11021"
},
{
"name": "BIP; GRP78; HEL-S-89n",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_005338",
"id": "NP_005338"
},
{
"name": "GRP78",
"resource": "UniProtKB",
"type": "synonym",
"url": "https://www.uniprot.org/uniprot/P11021",
"id": "P11021"
},
{
"name": "HSPA5",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_005338",
"id": "NP_005338"
}
],
"protein_names": [
{
"name": "Endoplasmic reticulum chaperone BiP",
"resource": "UniProtKB",
"type": "recommended",
"url": "",
"id": "P11021"
},
{
"name": "3.6.4.10",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P11021"
},
{
"name": "78 kDa glucose-regulated protein; immunoglobulin heavy chain-binding protein; endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; HSP70 family protein 5; epididymis secretory sperm binding protein Li 89n; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); binding-immunoglobulin protein; heat shock protein family A member 5; heat shock protein 70 family protein 5; endoplasmic reticulum chaperone BiP",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_005338",
"id": "NP_005338"
},
{
"name": "78 kDa glucose-regulated protein",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P11021"
},
{
"name": "BiP",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P11021"
},
{
"name": "Binding-immunoglobulin protein",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P11021"
},
{
"name": "GRP-78",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P11021"
},
{
"name": "HSP70 family protein 5",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P11021"
},
{
"name": "Heat shock protein 70 family protein 5",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P11021"
},
{
"name": "Heat shock protein family A member 5",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P11021"
},
{
"name": "Immunoglobulin heavy chain-binding protein",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P11021"
},
{
"name": "endoplasmic reticulum chaperone BiP precursor",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_005338",
"id": "NP_005338"
}
],
"function": [
{
"annotation": "(Microbial infection) Acts as a receptor for CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi (PubMed:24355926, PubMed:20484814, PubMed:32487760). Acts as a receptor for R.delemar CotH3 in nasal epithelial cells, which may be an early step in rhinoorbital/cerebral mucormycosis (RCM) disease progression (PubMed:32487760).",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021#function"
},
{
"database": "PubMed",
"id": "32487760",
"url": "https://glygen.org/publication/PubMed/32487760"
},
{
"database": "PubMed",
"id": "24355926",
"url": "https://glygen.org/publication/PubMed/24355926"
},
{
"database": "PubMed",
"id": "20484814",
"url": "https://glygen.org/publication/PubMed/20484814"
}
]
},
{
"annotation": "(Microbial infection) Plays an important role in viral binding to the host cell membrane and entry for several flaviruses such as Dengue virus, Zika virus and Japanese encephalitis virus (PubMed:33432092, PubMed:15098107, PubMed:28053106). Acts as a component of the cellular receptor for Dengue virus serotype 2/DENV-2 on human liver cells (PubMed:15098107).",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021#function"
},
{
"database": "PubMed",
"id": "33432092",
"url": "https://glygen.org/publication/PubMed/33432092"
},
{
"database": "PubMed",
"id": "28053106",
"url": "https://glygen.org/publication/PubMed/28053106"
},
{
"database": "PubMed",
"id": "15098107",
"url": "https://glygen.org/publication/PubMed/15098107"
}
]
},
{
"annotation": "Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:1550958, PubMed:19538957). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (PubMed:26045166).",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021#function"
},
{
"database": "PubMed",
"id": "23769672",
"url": "https://glygen.org/publication/PubMed/23769672"
},
{
"database": "UniProtKB",
"id": "P20029",
"url": "https://www.uniprot.org/uniprot/P20029#function"
},
{
"database": "PubMed",
"id": "2294010",
"url": "https://glygen.org/publication/PubMed/2294010"
},
{
"database": "PubMed",
"id": "23990668",
"url": "https://glygen.org/publication/PubMed/23990668"
},
{
"database": "PubMed",
"id": "28332555",
"url": "https://glygen.org/publication/PubMed/28332555"
},
{
"database": "PubMed",
"id": "26045166",
"url": "https://glygen.org/publication/PubMed/26045166"
},
{
"database": "UniProtKB",
"id": "G3I8R9",
"url": "https://www.uniprot.org/uniprot/G3I8R9#function"
},
{
"database": "PubMed",
"id": "1550958",
"url": "https://glygen.org/publication/PubMed/1550958"
},
{
"database": "PubMed",
"id": "29719251",
"url": "https://glygen.org/publication/PubMed/29719251"
},
{
"database": "PubMed",
"id": "19538957",
"url": "https://glygen.org/publication/PubMed/19538957"
}
]
},
{
"annotation": "LncRNA HOTAIRM1 Activated by HOXA4 Drives HUVEC Proliferation Through Direct Interaction with Protein Partner HSPA5.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_005338",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_005338"
},
{
"database": "PubMed",
"id": "37898994",
"url": "https://glygen.org/publication/PubMed/37898994"
}
]
},
{
"annotation": "NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_005338",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_005338"
},
{
"database": "PubMed",
"id": "37807968",
"url": "https://glygen.org/publication/PubMed/37807968"
}
]
},
{
"annotation": "Nuclear GRP78 Promotes Metabolic Reprogramming and Therapeutic Resistance in Pancreatic Ductal Adenocarcinoma.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_005338",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_005338"
},
{
"database": "PubMed",
"id": "37819952",
"url": "https://glygen.org/publication/PubMed/37819952"
}
]
},
{
"annotation": "PLXNC1 interference alleviates the inflammatory injury, apoptosis and extracellular matrix degradation of IL-1beta-exposed chondrocytes via suppressing GRP78 expression. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_005338",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_005338"
},
{
"database": "PubMed",
"id": "37853395",
"url": "https://glygen.org/publication/PubMed/37853395"
}
]
},
{
"annotation": "Research progress on the GRP78 gene in the diagnosis, treatment and immunity of cervical cancer. Review article Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_005338",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_005338"
},
{
"database": "PubMed",
"id": "37858217",
"url": "https://glygen.org/publication/PubMed/37858217"
}
]
},
{
"annotation": "The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers. [provided by RefSeq, Jul 2020].",
"evidence": [
{
"database": "RefSeq",
"id": "NP_005338",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_005338"
}
]
}
],
"disease": [],
"snv": [
{
"evidence": [
{
"id": "P11021",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P11021"
}
],
"glycoeffect": [
"n-glyco-sequon-gain",
"o-glyco-site-loss"
],
"start_pos": 122,
"end_pos": 122,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "K",
"sequence_mut": "N",
"comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (KKT->NKT).",
"chr_id": "9",
"chr_pos": "125240298",
"ref_nt": "C",
"alt_nt": "G",
"minor_allelic_frequency": "",
"site_lbl": "K122",
"disease": [
{
"disease_id": "DOID:11934",
"recommended_name": {
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck cancer",
"description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
},
"synonyms": [
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck tumours",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head/neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "tumor of head and neck",
"description": ""
}
]
},
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease"
]
},
{
"evidence": [
{
"id": "rs1229759275",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1229759275"
},
{
"id": "rs1229759275",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs1229759275"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 196,
"end_pos": 196,
"sequence_org": "M",
"sequence_mut": "T",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NVM->NVT).",
"chr_id": "9",
"chr_pos": "125239439",
"ref_nt": "G",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "M196",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "P11021",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P11021"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 231,
"end_pos": 231,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "D",
"sequence_mut": "N",
"comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (DVS->NVS).",
"chr_id": "9",
"chr_pos": "125239246",
"ref_nt": "C",
"alt_nt": "T",
"minor_allelic_frequency": "",
"site_lbl": "D231",
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
},
{
"disease_id": "DOID:1793",
"recommended_name": {
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "pancreatic cancer",
"description": "An endocrine gland cancer located_in the pancreas."
},
"synonyms": [
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "Ca body of pancreas",
"description": ""
},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "Ca head of pancreas",
"description": ""
},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "Ca tail of pancreas",
"description": ""
},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "malignant neoplasm of body of pancreas",
"description": ""
},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "malignant neoplasm of head of pancreas",
"description": ""
},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "malignant neoplasm of tail of pancreas",
"description": ""
},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "pancreas neoplasm",
"description": ""
},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "pancreatic neoplasm",
"description": ""
},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "pancreatic tumor",
"description": ""
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease"
]
},
{
"evidence": [
{
"id": "rs1415653914",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1415653914"
},
{
"id": "rs1415653914",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs1415653914"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 284,
"end_pos": 284,
"sequence_org": "A",
"sequence_mut": "T",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NRA->NRT).",
"chr_id": "9",
"chr_pos": "125239087",
"ref_nt": "T",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "A284",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "P11021",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P11021"
}
],
"glycoeffect": [
"n-glyco-sequon-gain",
"o-glyco-site-loss"
],
"start_pos": 352,
"end_pos": 352,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "K",
"sequence_mut": "N",
"comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (KKS->NKS).",
"chr_id": "9",
"chr_pos": "125238768",
"ref_nt": "C",
"alt_nt": "A",
"minor_allelic_frequency": "",
"site_lbl": "K352",
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
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"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "HPC8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "predisposing for prostate cancer",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, type 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "HPC6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "HPC10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate carcinoma",
"description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate carcinoma",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, somatic",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, hereditary",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "HPC7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer aggressiveness",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "RNASEL familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "familial prostate cancer caused by mutation in RNASEL",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, type 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "HPC1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "Prca1",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "HPC11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "HPC14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "HPC15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "HPCX1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer susceptibility, X-linked",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "HPCX2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MIM:611868",
"resource": "MIM",
"url": "https://www.omim.org/entry/611868",
"name": "Prostate cancer, hereditary, 12",
"description": "Prostate cancer, hereditary, 12"
},
{
"id": "MIM:611928",
"resource": "MIM",
"url": "https://www.omim.org/entry/611928",
"name": "Prostate cancer, hereditary, 13",
"description": "Prostate cancer, hereditary, 13"
},
{
"id": "MIM:176807",
"resource": "MIM",
"url": "https://www.omim.org/entry/176807",
"name": "Prostate cancer",
"description": "Prostate cancer"
},
{
"id": "MIM:601518",
"resource": "MIM",
"url": "https://www.omim.org/entry/601518",
"name": "Prostate cancer, hereditary, 1",
"description": "Prostate cancer, hereditary, 1"
},
{
"id": "MIM:611955",
"resource": "MIM",
"url": "https://www.omim.org/entry/611955",
"name": "Prostate cancer, hereditary, 11",
"description": "Prostate cancer, hereditary, 11"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Stomach cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10534",
"evidence": [
{
"database": "BioXpress",
"id": "P11021",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11021"
}
],
"disease": [
{
"disease_id": "DOID:10534",
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"resource": "Disease Ontology",
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},
"synonyms": [
{
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"description": ""
},
{
"id": "DOID:10534",
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"name": "gastric neoplasm",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": "A primary or metastatic malignant neoplasm involving the stomach."
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca lesser curvature - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "cancer of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer risk after h. pylori infection",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumor",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumour",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant stomach neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "stomach cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca body - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
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},
{
"id": "MONDO:0001056",
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"name": "malignant neoplasm of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, intestinal",
"description": ""
},
{
"id": "MIM:613659",
"resource": "MIM",
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"name": "Gastric cancer",
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}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Urinary bladder cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11054",
"evidence": [
{
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{
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},
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},
{
"id": "DOID:11054",
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"url": "http://disease-ontology.org/term/DOID:11054",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": "A primary or metastatic malignant neoplasm involving the bladder."
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
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"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "bladder cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "cancer of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, urinary bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
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"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumour",
"description": ""
},
{
"id": "MIM:109800",
"resource": "MIM",
"url": "https://www.omim.org/entry/109800",
"name": "Bladder cancer",
"description": "Bladder cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Head and neck cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11934",
"evidence": [
{
"database": "BioXpress",
"id": "P11021",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11021"
}
],
"disease": [
{
"disease_id": "DOID:11934",
"recommended_name": {
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck cancer",
"description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
},
"synonyms": [
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck tumours",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head/neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "tumor of head and neck",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Lung cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1324",
"evidence": [
{
"database": "BioXpress",
"id": "P11021",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11021"
}
],
"disease": [
{
"disease_id": "DOID:1324",
"recommended_name": {
"id": "DOID:1324",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1324",
"name": "lung cancer",
"description": "A respiratory system cancer that is located_in the lung."
},
"synonyms": [
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "LNCR1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "LNCR3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "adenocarcinoma of lung, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "LNCR4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "LNCR5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": "A malignant neoplasm involving the lung."
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "cancer of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung neoplasm",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumor",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumour",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung neoplasm",
"description": ""
},
{
"id": "MIM:211980",
"resource": "MIM",
"url": "https://www.omim.org/entry/211980",
"name": "Lung cancer",
"description": "Lung cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Breast cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1612",
"evidence": [
{
"database": "BioXpress",
"id": "P11021",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11021"
}
],
"disease": [
{
"disease_id": "DOID:1612",
"recommended_name": {
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast cancer",
"description": "A thoracic cancer that originates in the mammary gland."
},
"synonyms": [
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant neoplasm of breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant tumor of the breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary cancer",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "primary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, lobular, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of the breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial Male",
"description": ""
},
{
"id": "MIM:114480",
"resource": "MIM",
"url": "https://www.omim.org/entry/114480",
"name": "Breast cancer",
"description": "Breast cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Thyroid cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1781",
"evidence": [
{
"database": "BioXpress",
"id": "P11021",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11021"
}
],
"disease": [
{
"disease_id": "DOID:1781",
"recommended_name": {
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid cancer",
"description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
},
"synonyms": [
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid gland cancer",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "Thyroid gland neoplasm",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant tumour of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Kidney cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:263",
"evidence": [
{
"database": "BioXpress",
"id": "P11021",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11021"
}
],
"disease": [
{
"disease_id": "DOID:263",
"recommended_name": {
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "kidney cancer",
"description": "A urinary system cancer that is located_in the kidney."
},
"synonyms": [
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant neoplasm of kidney except pelvis",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant tumour of kidney",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "renal cancer",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Liver cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:3571",
"evidence": [
{
"database": "BioXpress",
"id": "P11021",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11021"
}
],
"disease": [
{
"disease_id": "DOID:3571",
"recommended_name": {
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "liver cancer",
"description": "A hepatobiliary system cancer that is located_in the liver."
},
"synonyms": [
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Ca liver - primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Resectable malignant neoplasm of Liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant hepato-biliary neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant tumor of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "non-resectable primary hepatic malignant neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary liver cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "resectable malignant neoplasm of the liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, not specified as primary or secondary",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Uterine cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:363",
"evidence": [
{
"database": "BioXpress",
"id": "P11021",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11021"
}
],
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
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"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
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"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
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"name": "uterine tumor",
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},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
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}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Esophageal cancer [DO disease name]",
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"evidence": [
{
"database": "BioXpress",
"id": "P11021",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11021"
}
],
"disease": [
{
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"name": "esophageal cancer",
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},
"synonyms": [
{
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"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophagus cancer",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
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"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
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"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Distal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Proximal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
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"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
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"name": "malignant tumor of the middle Third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": "A primary or metastatic malignant neoplasm involving the esophagus."
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumor",
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},
{
"id": "MONDO:0007576",
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"name": "malignant esophageal tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
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},
{
"id": "MONDO:0007576",
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"name": "malignant tumour of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "oesophagus cancer",
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},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of lower third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of middle third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of proximal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of upper third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of distal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of proximal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of the middle third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of abdominal oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of distal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of proximal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of the middle third of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Aerodigestive tract cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Escc, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "gastric cardia adenocarcinoma, susceptibility to",
"description": ""
},
{
"id": "MIM:133239",
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"name": "Esophageal cancer",
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}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Colorectal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:9256",
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{
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"id": "P11021",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P11021"
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],
"disease": [
{
"disease_id": "DOID:9256",
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},
"synonyms": [
{
"id": "MONDO:0005575",
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},
{
"id": "MONDO:0005575",
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"name": "cancer of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large bowel",
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},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
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"name": "cancer of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, advanced, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
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"name": "colon cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer with chromosomal instability, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
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"name": "colorectal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
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},
{
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"name": "colorectum cancer",
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},
{
"id": "MONDO:0005575",
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"name": "malignant colorectal neoplasm",
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},
{
"id": "MONDO:0005575",
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"name": "malignant colorectal tumor",
"description": ""
},
{
"id": "MONDO:0005575",
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"name": "malignant colorectal tumour",
"description": ""
},
{
"id": "MONDO:0005575",
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"name": "malignant colorectum neoplasm",
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},
{
"id": "MONDO:0005575",
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"name": "malignant large bowel neoplasm",
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},
{
"id": "MONDO:0005575",
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},
{
"id": "MONDO:0005575",
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"length": 654,
"header": "sp|P11021-1|BIP_HUMAN Isoform 1 of Endoplasmic reticulum chaperone BiP OS=Homo sapiens OX=9606 GN=HSPA5 PE=1 SV=2 CANONICAL=P11021-1"
},
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"length": 623,
"header": "tr|A0A7P0TB36-1|A0A7P0TB36_HUMAN Computationally mapped isoform of 78 kDa glucose-regulated protein OS=Homo sapiens OX=9606 GN=HSPA5 PE=1 SV=1 CANONICAL=P11021-1"
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"isoform_ac": "P11021-1",
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"date": "2003",
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"title": "Novel interactions of CLN3 protein link Batten disease to dysregulation of fodrin-Na+, K+ ATPase complex.",
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"date": "2008",
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"date": "2013-09-18",
"authors": "Evensen Nikki A, Kuscu Cem, Nguyen Hoang-Lan, Zarrabi Kevin, Dufour Antoine, Kadam Pournima, Hu You-Jun, Pulkoski-Gross Ashleigh, Bahou Wadie F, Zucker Stanley, Cao Jian",
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"title": "Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.",
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"date": "2014",
"authors": "Guo A, Gu H, Zhou J, Mulhern D, Wang Y, Lee KA, Yang V, Aguiar M, Kornhauser J, Jia X, Ren J, Beausoleil SA, Silva JC, Vemulapalli V, Bedford MT, Comb MJ",
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"title": "N-linked glycosylation enrichment for in-depth cell surface proteomics of diffuse large B-cell lymphoma subtypes.",
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"date": "2014",
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"id": "GLY_000143",
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"type": "PubMed",
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]
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"title": "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.",
"journal": "Journal of proteomics",
"date": "2014",
"authors": "Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H",
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"database": "iPTMnet",
"id": "P11021",
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]
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"title": "CotH3 mediates fungal invasion of host cells during mucormycosis.",
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"date": "2014-01",
"authors": "Gebremariam Teclegiorgis, Liu Mingfu, Luo Guanpingsheng, Bruno Vincent, Phan Quynh T, Waring Alan J, Edwards John E, Filler Scott G, Yeaman Michael R, Ibrahim Ashraf S",
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"id": "P11021",
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"title": "Specific associations of fluorescent beta-2-microglobulin with cell surfaces. The affinity of different H-2 and HLA antigens for beta-2-microglobulin.",
"journal": "Journal of immunology (Baltimore, Md. : 1950)",
"date": "1988",
"authors": "Hochman JH, Shimizu Y, DeMars R, Edidin M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-983170",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983170"
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"type": "PubMed",
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]
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"title": "Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.",
"journal": "Proc. Natl. Acad. Sci. U.S.A.",
"date": "2014",
"authors": "Impens F, Radoshevich L, Cossart P, Ribet D",
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"database": "UniProtKB",
"id": "P11021",
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"type": "PubMed",
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"url": "https://glygen.org/publication/PubMed/25114211"
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]
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{
"title": "Uncovering global SUMOylation signaling networks in a site-specific manner.",
"journal": "Nat. Struct. Mol. Biol.",
"date": "2014",
"authors": "Hendriks IA, D'Souza RC, Yang B, Verlaan-de Vries M, Mann M, Vertegaal AC",
"evidence": [
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"database": "UniProtKB",
"id": "P11021",
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]
},
{
"title": "ATF6\u03b2 regulates the Wfs1 gene and has a cell survival role in the ER stress response in pancreatic \u03b2-cells.",
"journal": "Experimental cell research",
"date": "2015-01-01",
"authors": "Odisho Tanya, Zhang Liling, Volchuk Allen",
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"database": "Reactome",
"id": "R-HSA-8874177",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8874177"
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"type": "PubMed",
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]
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"title": "A novel link between Fic (filamentation induced by cAMP)-mediated adenylylation/AMPylation and the unfolded protein response.",
"journal": "The Journal of biological chemistry",
"date": "2015",
"authors": "Sanyal A, Chen AJ, Nakayasu ES, Lazar CS, Zbornik EA, Worby CA, Koller A, Mattoo S",
"evidence": [
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"database": "UniProtKB",
"id": "P11021",
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"title": "System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.",
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"date": "2015",
"authors": "Xiao Zhenyu, Chang Jer-Gung, Hendriks Ivo A, Sigur\u00f0sson J\u00f3n Otti, Olsen Jesper V, Vertegaal Alfred C O",
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"title": "Probing the O-glycoproteome of gastric cancer cell lines for biomarker discovery.",
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"date": "2015",
"authors": "Campos D, Freitas D, Gomes J, Magalhaes A, Steentoft C, Gomes C, Vester-Christensen MB, Ferreira JA, Afonso LP, Santos LL, Pinto de Sousa J, Mandel U, Clausen H, Vakhrushev SY, Reis CA",
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"type": "PubMed",
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]
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"title": "KIAA1324 Suppresses Gastric Cancer Progression by Inhibiting the Oncoprotein GRP78.",
"journal": "Cancer research",
"date": "2015-08-01",
"authors": "Kang Jin Muk, Park Sujin, Kim Staci Jakyong, Kim Hyojung, Lee Bona, Kim Junil, Park Jinah, Kim Shin Tae, Yang Han-Kwang, Kim Woo Ho, Kim Seong-Jin",
"evidence": [
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"database": "UniProtKB",
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]
},
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"title": "Placental endoplasmic reticulum stress negatively regulates transcription of placental growth factor via ATF4 and ATF6beta: implications for the pathophysiology of human pregnancy complications.",
"journal": "The Journal of pathology",
"date": "2016",
"authors": "Mizuuchi M, Cindrova-Davies T, Olovsson M, Charnock-Jones DS, Burton GJ, Yung HW",
"evidence": [
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"database": "Reactome",
"id": "R-HSA-8874177",
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"type": "PubMed",
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]
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"title": "Close and Allosteric Opening of the Polypeptide-Binding Site in a Human Hsp70 Chaperone BiP.",
"journal": "Structure (London, England : 1993)",
"date": "2015",
"authors": "Yang J, Nune M, Zong Y, Zhou L, Liu Q",
"evidence": [
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"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
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]
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"title": "Versatile function of the circadian protein CIPC as a regulator of Erk activation.",
"journal": "Biochem. Biophys. Res. Commun.",
"date": "2016",
"authors": "Matsunaga R, Nishino T, Yokoyama A, Nakashima A, Kikkawa U, Konishi H",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
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"type": "PubMed",
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"title": "Comparative analysis of Cu (I)-catalyzed alkyne-azide cycloaddition (CuAAC) and strain-promoted alkyne-azide cycloaddition (SPAAC) in O-GlcNAc proteomics.",
"journal": "Electrophoresis",
"date": "2016",
"authors": "Li S, Zhu H, Wang J, Wang X, Li X, Ma C, Wen L, Yu B, Wang Y, Li J, Wang PG",
"evidence": [
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"database": "O-GlcNAc Database",
"id": "P11021",
"url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11021"
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"type": "PubMed",
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]
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"title": "Glucose-regulated protein 78 (GRP78) binds directly to PIP3 phosphatase SKIP and determines its localization.",
"journal": "Genes Cells",
"date": "2016",
"authors": "Ijuin T, Hatano N, Takenawa T",
"evidence": [
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"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
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"type": "PubMed",
"id": "26940976",
"url": "https://glygen.org/publication/PubMed/26940976"
}
]
},
{
"title": "Bicarbonate correction of ketoacidosis alters host-pathogen interactions and alleviates mucormycosis.",
"journal": "J. Clin. Invest.",
"date": "2016",
"authors": "Gebremariam Teclegiorgis, Lin Lin, Liu Mingfu, Kontoyiannis Dimitrios P, French Samuel, Edwards John E, Filler Scott G, Ibrahim Ashraf S",
"evidence": [
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"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
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],
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"type": "PubMed",
"id": "27159390",
"url": "https://glygen.org/publication/PubMed/27159390"
}
]
},
{
"title": "GRP78 Is an Important Host Factor for Japanese Encephalitis Virus Entry and Replication in Mammalian Cells.",
"journal": "Journal of virology",
"date": "2017-03-15",
"authors": "Nain Minu, Mukherjee Sriparna, Karmakar Sonali Porey, Paton Adrienne W, Paton James C, Abdin M Z, Basu Anirban, Kalia Manjula, Vrati Sudhanshu",
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"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
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{
"type": "PubMed",
"id": "28053106",
"url": "https://glygen.org/publication/PubMed/28053106"
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]
},
{
"title": "HSPA5 Gene encoding Hsp70 chaperone BiP in the endoplasmic reticulum.",
"journal": "Gene",
"date": "2017",
"authors": "Wang Jie, Lee Jessica, Liem David, Ping Peipei",
"evidence": [
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"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
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"type": "PubMed",
"id": "28286085",
"url": "https://glygen.org/publication/PubMed/28286085"
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]
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{
"title": "LOXL2 drives epithelial-mesenchymal transition via activation of IRE1-XBP1 signalling pathway.",
"journal": "Scientific reports",
"date": "2017",
"authors": "Cuevas EP, Eraso P, Mazon MJ, Santos V, Moreno-Bueno G, Cano A, Portillo F",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
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"type": "PubMed",
"id": "28332555",
"url": "https://glygen.org/publication/PubMed/28332555"
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]
},
{
"title": "Human gene encoding the 78,000-dalton glucose-regulated protein and its pseudogene: structure, conservation, and regulation.",
"journal": "DNA",
"date": "1988",
"authors": "Ting J, Lee A S",
"evidence": [
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"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
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"type": "PubMed",
"id": "2840249",
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}
]
},
{
"title": "Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection.",
"journal": "Nat. Commun.",
"date": "2018",
"authors": "Bai M, Vozdek R, Hnizda A, Jiang C, Wang B, Kuchar L, Li T, Zhang Y, Wood C, Feng L, Dang Y, Ma DK",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
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"id": "29497057",
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}
]
},
{
"title": "Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier.",
"journal": "Cell reports",
"date": "2018",
"authors": "Hassdenteufel S, Johnson N, Paton AW, Paton JC, High S, Zimmermann R",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
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"type": "PubMed",
"id": "29719251",
"url": "https://glygen.org/publication/PubMed/29719251"
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]
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{
"title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.",
"journal": "ACS chemical biology",
"date": "2018",
"authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X",
"evidence": [
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"database": "O-GlcNAc Database",
"id": "P11021",
"url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11021"
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"database": "O-GlcNAc Atlas",
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"type": "PubMed",
"id": "30059200",
"url": "https://glygen.org/publication/PubMed/30059200"
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"title": "Combinatorial regulation of hepatic cytoplasmic signaling and nuclear transcriptional events by the OGT/REV-ERBalpha complex.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "2018",
"authors": "Berthier A, Vinod M, Porez G, Steenackers A, Alexandre J, Yamakawa N, Gheeraert C, Ploton M, Marechal X, Dubois-Chevalier J, Hovasse A, Schaeffer-Reiss C, Cianferani S, Rolando C, Bray F, Duez H, Eeckhoute J, Lefebvre T, Staels B, Lefebvre P",
"evidence": [
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"database": "O-GlcNAc Database",
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"url": "https://www.oglcnac.mcw.edu/search/?query_protein=P11021"
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"type": "PubMed",
"id": "30397120",
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]
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"title": "O-GlcNAc-induced nuclear translocation of hnRNP-K is associated with progression and metastasis of cholangiocarcinoma.",
"journal": "Molecular oncology",
"date": "2019",
"authors": "Phoomak C, Park D, Silsirivanit A, Sawanyawisuth K, Vaeteewoottacharn K, Detarya M, Wongkham C, Lebrilla CB, Wongkham S",
"evidence": [
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"database": "O-GlcNAc Database",
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"title": "Eukaryotic Initiation Factor 5B (eIF5B) Cooperates with eIF1A and eIF5 to Facilitate uORF2-Mediated Repression of ATF4 Translation.",
"journal": "International journal of molecular sciences",
"date": "2018",
"authors": "Ross JA, Bressler KR, Thakor N",
"evidence": [
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"database": "Reactome",
"id": "R-HSA-381042",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381042"
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"title": "Engineering a Proximity-Directed O-GlcNAc Transferase for Selective Protein O-GlcNAcylation in Cells.",
"journal": "ACS chemical biology",
"date": "2020",
"authors": "Ramirez DH, Aonbangkhen C, Wu HY, Naftaly JA, Tang S, O'Meara TR, Woo CM",
"evidence": [
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"database": "O-GlcNAc Database",
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"date": "2020-06-02",
"authors": "Alqarihi Abdullah, Gebremariam Teclegiorgis, Gu Yiyou, Swidergall Marc, Alkhazraji Sondus, Soliman Sameh S M, Bruno Vincent M, Edwards John E, Filler Scott G, Uppuluri Priya, Ibrahim Ashraf S",
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"title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.",
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"date": "2020",
"authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J",
"evidence": [
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"date": "2021-01-11",
"authors": "Khongwichit Sarawut, Sornjai Wannapa, Jitobaom Kunlakanya, Greenwood Mingkwan, Greenwood Michael P, Hitakarun Atitaya, Wikan Nitwara, Murphy David, Smith Duncan R",
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"date": "2021",
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"id": "45919030",
"url": "http://www.informatics.jax.org/homology/45919030",
"database": "MGI"
},
{
"id": "P11021",
"url": "https://omabrowser.org/oma/group/P11021/",
"database": "OMA"
}
],
"common_name": "Mouse"
},
{
"uniprot_canonical_ac": "P29844-1",
"protein_name": "Endoplasmic reticulum chaperone BiP",
"gene_name": "Hsc70-3",
"tax_id": 7227,
"organism": "Drosophila melanogaster",
"sequence": {
"sequence": "MKLCILLAVVAFVGLSLGEEKKEKDKELGTVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTVFDAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDKKEGEKNVLVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRAVQKLRREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGEQDTDAIVLLDVNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTKDNHLLGKFDLTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVITNDQNRLTPEDIDRMIRDAEKFADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKLSDDEKNKLESAIDESIKWLEQNPDADPEEYKKQKKDLEAIVQPVIAKLYQGAGGAPPPEGGDDADLKDEL",
"length": 656
},
"evidence": [
{
"id": "P11021",
"url": "https://omabrowser.org/oma/group/P11021/",
"database": "OMA"
}
],
"common_name": "Fruit fly"
}
],
"go_annotation": {
"categories": [
{
"name": "Molecular Function",
"total": 14,
"go_terms": [
{
"name": "ATP binding",
"id": "GO:0005524",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "ATP-dependent protein folding chaperone",
"id": "GO:0140662",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140662",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "enzyme binding",
"id": "GO:0019899",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "protein domain specific binding",
"id": "GO:0019904",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "unfolded protein binding",
"id": "GO:0051082",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "protein-folding chaperone binding",
"id": "GO:0051087",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051087",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "ATP hydrolysis activity",
"id": "GO:0016887",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "heat shock protein binding",
"id": "GO:0031072",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031072",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "ubiquitin protein ligase binding",
"id": "GO:0031625",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "calcium ion binding",
"id": "GO:0005509",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "cadherin binding",
"id": "GO:0045296",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045296",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "ribosome binding",
"id": "GO:0043022",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043022",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "misfolded protein binding",
"id": "GO:0051787",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051787",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "protein folding chaperone",
"id": "GO:0044183",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044183",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
}
]
},
{
"name": "Cellular Component",
"total": 18,
"go_terms": [
{
"name": "endoplasmic reticulum lumen",
"id": "GO:0005788",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "cell surface",
"id": "GO:0009986",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "melanosome",
"id": "GO:0042470",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042470",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "endoplasmic reticulum chaperone complex",
"id": "GO:0034663",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034663",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "nucleus",
"id": "GO:0005634",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "cytoplasm",
"id": "GO:0005737",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "mitochondrion",
"id": "GO:0005739",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "endoplasmic reticulum",
"id": "GO:0005783",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "cytosol",
"id": "GO:0005829",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "plasma membrane",
"id": "GO:0005886",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "focal adhesion",
"id": "GO:0005925",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "membrane",
"id": "GO:0016020",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "intracellular membrane-bounded organelle",
"id": "GO:0043231",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "extracellular exosome",
"id": "GO:0070062",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "endoplasmic reticulum membrane",
"id": "GO:0005789",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "midbody",
"id": "GO:0030496",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "endoplasmic reticulum-Golgi intermediate compartment",
"id": "GO:0005793",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005793",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "protein-containing complex",
"id": "GO:0032991",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
}
]
},
{
"name": "Biological Process",
"total": 24,
"go_terms": [
{
"name": "regulation of IRE1-mediated unfolded protein response",
"id": "GO:1903894",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903894",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "positive regulation of cell migration",
"id": "GO:0030335",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "negative regulation of apoptotic process",
"id": "GO:0043066",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "substantia nigra development",
"id": "GO:0021762",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021762",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "positive regulation of protein ubiquitination",
"id": "GO:0031398",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031398",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "cellular response to glucose starvation",
"id": "GO:0042149",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042149",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "negative regulation of protein-containing complex assembly",
"id": "GO:0031333",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031333",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "cerebellar Purkinje cell layer development",
"id": "GO:0021680",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021680",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "ubiquitin-dependent ERAD pathway",
"id": "GO:0030433",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030433",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "endoplasmic reticulum unfolded protein response",
"id": "GO:0030968",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030968",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "negative regulation of transforming growth factor beta receptor signaling pathway",
"id": "GO:0030512",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030512",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress",
"id": "GO:1990440",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990440",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "ER overload response",
"id": "GO:0006983",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006983",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "cellular response to interleukin-4",
"id": "GO:0071353",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071353",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "protein refolding",
"id": "GO:0042026",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042026",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "chaperone cofactor-dependent protein refolding",
"id": "GO:0051085",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051085",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "post-translational protein targeting to membrane, translocation",
"id": "GO:0031204",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031204",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "negative regulation of IRE1-mediated unfolded protein response",
"id": "GO:1903895",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903895",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "protein folding in endoplasmic reticulum",
"id": "GO:0034975",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034975",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "cerebellum structural organization",
"id": "GO:0021589",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021589",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "maintenance of protein localization in endoplasmic reticulum",
"id": "GO:0035437",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035437",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "regulation of protein folding in endoplasmic reticulum",
"id": "GO:0060904",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060904",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "regulation of ATF6-mediated unfolded protein response",
"id": "GO:1903891",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903891",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
},
{
"name": "regulation of PERK-mediated unfolded protein response",
"id": "GO:1903897",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903897",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
}
],
"pmid": ""
}
]
}
]
},
"pro_annotation": [],
"site_annotation": [],
"ptm_annotation": [
{
"annotation": "AMPylated by FICD (PubMed:25601083). In unstressed cells, AMPylation at Thr-518 by FICD inactivates the chaperome activity: AMPylated form is locked in a relatively inert state and only weakly stimulated by J domain-containing proteins (By similarity). In response to endoplasmic reticulum stress, de-AMPylation by the same protein, FICD, restores the chaperone activity (By similarity).",
"evidence": [
{
"database": "UniProtKB",
"id": "P11021",
"url": "https://www.uniprot.org/uniprot/P11021"
},
{
"database": "PubMed",
"id": "25601083",
"url": "https://glygen.org/publication/PubMed/25601083"
}
]
}
],
"interactions": [],
"reactions": [
{
"id": "13065",
"name": "",
"equation": "ATP + H2O = ADP + H(+) + phosphate",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"D3ZD32-1",
"A0A8I5ZKX7-1",
"D4A7Q5-1",
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],
"evidence": [
{
"id": "13065",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/13065"
}
]
},
{
"id": "R-HSA-1791150",
"name": "Expression of BIP (78 kDa Glucose-regulated protein, GRP78, HSPA5)",
"equation": "",
"summary": "The BIP (HSPA5) gene is transcribed to yield mRNA and the mRNA is translated to yield protein.",
"cellular_location": "endoplasmic reticulum membrane, nucleoplasm",
"input_participant_list": [
"R-HSA-5642261"
],
"output_participant_list": [],
"enzyme_list": [
"P11021-1"
],
"evidence": [
{
"id": "R-HSA-1791150",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1791150"
}
]
},
{
"id": "R-HSA-351323",
"name": "Release of 78 kDa glucose-regulated protein",
"equation": "",
"summary": "After Platelet activation '78 kDa glucose-regulated protein' from the endoplasmic reticulum lumen is released in to the extracellular platelet releasate.",
"cellular_location": "endoplasmic reticulum membrane, extracellular region",
"input_participant_list": [
"R-HSA-351315"
],
"output_participant_list": [
"R-HSA-351322"
],
"enzyme_list": [
"P11021-1"
],
"evidence": [
{
"id": "R-HSA-351323",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-351323"
}
]
},
{
"id": "R-HSA-381086",
"name": "Dissociation of PERK:BiP Heterodimer",
"equation": "",
"summary": "PERK (EIF2AK3) is a single-pass transmembrane protein located in the Endoplasmic Reticulum (ER) membrane. PERK has an N-terminal luminal domain and a C-terminal cytosolic domain. It is maintained in an inactive state by association of its luminal domain with BiP, a chaperone in the ER. Because BiP also binds unfolded proteins, BiP dissociates from PERK when unfolded proteins exceed chaperone activity in the ER.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-HSA-381130"
],
"output_participant_list": [
"R-HSA-381046"
],
"enzyme_list": [
"P11021-1",
"Q9NZJ5-1"
],
"evidence": [
{
"id": "R-HSA-381086",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381086"
}
]
},
{
"id": "R-HSA-381158",
"name": "ATF6:HSPA5 (ATF6-alpha:BiP) dissociates and HSPA5 binds unfolded protein",
"equation": "",
"summary": "ATF6-alpha is a transmembrane protein located in the endoplasmic reticulum (ER) membrane with N-terminal cytoplasmic and C-terminal luminal domains. BiP binds the luminal domain of ATF6-alpha via the substrate binding domain of BiP. Binding of BiP blocks 2 Golgi localization sequences on ATF6-alpha, maintaining ATF6-alpha in the ER.
BiP is also a general chaperone capable of binding unfolded proteins in the ER lumen. When chaperone activity in the ER is overwhelmed, BiP dissociates from ATF6-alpha and binds the excess unfolded proteins. It is unclear whether the dissociation is due to competition of unfolded proteins for BiP or to a more specific interaction between BiP and ATF6-alpha. The dissociation exposes the Golgi localization sequences of ATF6-alpha and allows ATF6-alpha to transit to the Golgi.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [],
"output_participant_list": [
"R-HSA-381222"
],
"enzyme_list": [
"P11021-1"
],
"evidence": [
{
"id": "R-HSA-381158",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381158"
}
]
},
{
"id": "R-HSA-381217",
"name": "IRE1:BiP dissociates in response to unfolded protein",
"equation": "",
"summary": "IRE1-alpha is a single-pass transmembrane protein with a luminal N-terminus and a cytoplasmic C-terminus. IRE1-alpha is maintained in an inactive state in the Endoplasmic Reticulum (ER) membrane by interaction between the luminal domain of IRE1-alpha and the ATPase domain of BiP within the ER.
BiP is a general chaperone that also binds unfolded proteins within the ER. Thus BiP dissociates from IRE1-alpha when chaperone activity is overwhelmed by unfolded proteins in the ER.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [],
"output_participant_list": [
"R-HSA-381076"
],
"enzyme_list": [
"P11021-1"
],
"evidence": [
{
"id": "R-HSA-381217",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381217"
}
]
},
{
"id": "R-HSA-5251942",
"name": "Hikeshi binds HSP70s:ATP",
"equation": "",
"summary": "Protein Hikeshi (C11orf73) is a nuclear import carrier protein for heat-shock 70 proteins (HSP70s) in response to heat-shock stress. C11orf73 binds HSP70s in the cytosol, ready for nuclear import (Kose et al. 2012).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1",
"P11021-1"
],
"evidence": [
{
"id": "R-HSA-5251942",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5251942"
}
]
},
{
"id": "R-HSA-5251955",
"name": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm",
"equation": "",
"summary": "Protein Hikeshi (C11orf73) is a nuclear import carrier protein for heat-shock 70 proteins (HSP70s) in response to heat-shock stress. It is only able to bind HSP70s when they are bound to ATP. DnaJ homolog subfamily members (aka heat-shock 40 proteins, HSP40s) also translocate to the nucleus under heat-shock stress (Hattori et al. 1992) and can act as stimulators of intrinsic ATPase activity of HSP70s. The result is that Hikeshi dissociates from HSP70:ADP.",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [
"R-HSA-5252048"
],
"enzyme_list": [
"P11142-1",
"P11021-1"
],
"evidence": [
{
"id": "R-HSA-5251955",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5251955"
}
]
},
{
"id": "R-HSA-5251959",
"name": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol",
"equation": "",
"summary": "Heat-shock 70kDa proteins (HSP70s) are a family of conserved, ubiquitously expressed heat-shock proteins which play important roles in protein folding and in protecting cells from stress. They possess three functional domains; an N-terminal ATPase domain, a substrate binding domain and a C-terminal domain. HSP70s are bound to either ATP or ADP. In the ATP-bound state, HSP70s do not interact with a substrate peptide as the C-terminal domain (which acts as a lid) is \\open\\, allowing peptides to bind to the substrate binding domain but then be released very rapidily. However, a substrate peptide in the binding domain can stimulate the intrinsic ATPase activity of HSP70s, hydrolysing ATP to ADP. With ADP bound, the C-terminal domain of HSP70s closes around the peptide, effectively trapping the peptide.
Intrinsic ATPase activity proceeds relatively slowly but can be dramatically increased by binding of J-domain chaperones such as HSP40s. These are eukaryotic orthologues of the DnaJ cochaperones found in prokaryotes. The human HSP40s that are able to modulate intrinsic ATPase activity of HSP70s are DNAJB1, B6, C2 and C7 (Raabe & Manley 1991, Melville et al. 1999, Hanai & Mashima 2003, Izawa et al. 2000, Hundley et al. 2005, Brychzy et al. 2003). They are also able to co-localise to the nucleus with HSP70s upon heat-shock (Hattori et al. 1992).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1",
"P11021-1"
],
"evidence": [
{
"id": "R-HSA-5251959",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5251959"
}
]
},
{
"id": "R-HSA-5252041",
"name": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm",
"equation": "",
"summary": "Protein Hikeshi (C11orf73) is a nuclear import carrier protein for heat-shock 70 proteins (HSP70s) in response to heat-shock stress. C11orf73-bound HSP70s bind to the nuclear pore complex (NPC) which transports the complex from the cytosol to the nucleoplasm where HSP70s can counteract heat shock-induced damage (Kose et al. 2012). NPC does not transport ADP-bound HSP70s.",
"cellular_location": "cytosol, nuclear envelope, nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1",
"P11021-1",
"P49792-1"
],
"evidence": [
{
"id": "R-HSA-5252041",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5252041"
}
]
},
{
"id": "R-HSA-5252079",
"name": "HSP110s exchange ATP for ADP on HSP70s:ADP",
"equation": "",
"summary": "The substrate binding ability of heat-shock 70kDa proteins (HSP70s) is dependant on their bound state to either ATP or ADP. Release of a protein substrate is induced when HSP70s are bound to ATP and conversely, proteins substrates bind when HSP70s are bound to ADP. Intrinsic ATPase of HSP70s slowly hydrolyses ATP to ADP. This process can be speeded up by cochaperones such as HSP40s which stimulate ATPase activity. Nucleotide exchange factors (NEFs) regulate the lifespan of the HSP70:ADP:substrate complex by exchanging ADP for ATP, thus inducing the release of the substrate. Eukaryote NEFs include heat-shock protein 105kDa (HSPH1 aka HSP110) (Schuermann et al. 2008) and the BAG family molecular chaperone regulator (BAG) family (BAG1-5). BAGs inhibit the chaperone activity of HSP70s by promoting substrate release (Takayama et al. 1997, Takayama et al. 1999). HSC70-interacting protein (ST13 aka HIP) is a 48kDa tetrameric protein able to bind the ATPase domain of HSP70s and thought to stabilise the ADP state of HSP70s (Hohfeld et al. 1995, Prapapanich et al. 1996).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11142-1",
"P11021-1"
],
"evidence": [
{
"id": "R-HSA-5252079",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5252079"
}
]
},
{
"id": "R-HSA-8874162",
"name": "ATF6B:HSPA5 (ATF6-beta:BiP) dissociates and HSPA5 binds unfolded protein",
"equation": "",
"summary": "Based on homology of the C-terminal lumenal domains of ATF6 and ATF6B, ATF6B is inferred to interact with HSPA5 (BiP, GRP78) and dissociate from HSPA5 as HSPA5 binds unfolded protein. The release of HSPA5 from ATF6B allows ATF6B to traffic from the endoplasmic reticulum to the Golgi where it is activated by cleavage.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [],
"output_participant_list": [
"R-HSA-8874179"
],
"enzyme_list": [
"P11021-1"
],
"evidence": [
{
"id": "R-HSA-8874162",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8874162"
}
]
},
{
"id": "R-HSA-983145",
"name": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin",
"equation": "",
"summary": "The newly synthesized MHC class I heavy chain (HC) translocates into the endoplasmic reticulum (ER) and binds rapidly to calnexin (CNX), a transmembrane calcium-dependent lectin with chaperone activity. CNX recognizes and binds to an N-linked monoglycosylated Glc1Man9GlcNAc2 carbohydrate group found attached to the conserved Asn-86 in the HC. Interaction of HC with CNX promotes the formation of intrachain disulfide bonds. Another candidate ER chaperon protein is immunoglobulin binding protein (BiP), found to associate with HC in the absence of CNX. These chaperones can cooperate in protein folding and prevention of aggregation.",
"cellular_location": "endoplasmic reticulum lumen, integral component of lumenal side of endoplasmic reticulum membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11021-1"
],
"evidence": [
{
"id": "R-HSA-983145",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983145"
}
]
},
{
"id": "R-HSA-983146",
"name": "Interaction of beta-2-microglobulin (B2M) chain with class I HC",
"equation": "",
"summary": "Interaction of calnexin (CNX) with MHC class I HC stabilizes it and facilitates the association of the beta2 microglobulin component (B2M). The two chains are linked noncovalently via interaction of B2M and the alpha3 domain of MHC HC. After formation of the HC:B2M heterodimer, the MHC complex dissociates from CNX.",
"cellular_location": "endoplasmic reticulum lumen, integral component of lumenal side of endoplasmic reticulum membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P30101-1",
"P11021-1"
],
"evidence": [
{
"id": "R-HSA-983146",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983146"
}
]
},
{
"id": "R-HSA-983148",
"name": "Interaction of Erp57 with MHC class I HC",
"equation": "",
"summary": "Endoplasmic reticulum resident protein 57 (ERp57), is a member of the protein disulphide isomerase (PDI) family of thiol oxidoreducatases. It associates with Calnexin (CNX), and its soluble homolog calreticulin (CRT) and is recruited to MHC Class I Heavy Chain (HC). ERp57 is involved in the formation of HC disulphide bonds.",
"cellular_location": "endoplasmic reticulum lumen, integral component of lumenal side of endoplasmic reticulum membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P30101-1",
"P11021-1"
],
"evidence": [
{
"id": "R-HSA-983148",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983148"
}
]
}
],
"reaction_participants": [
{
"participant_id": "R-HSA-351315",
"participant_name": "HSPA5 [endoplasmic reticulum membrane]",
"crossref": [
{
"id": "P11021",
"database": "UniProt",
"url": ""
},
{
"id": "6DWS",
"database": "PDB",
"url": ""
},
{
"id": "GRP78_HUMAN",
"database": "ZINC - Metabolites",
"url": ""
},
{
"id": "5F1X",
"database": "PDB",
"url": ""
},
{
"id": "6DFO",
"database": "PDB",
"url": ""
},
{
"id": "P11021",
"database": "GeneCards",
"url": ""
},
{
"id": "3LDN",
"database": "PDB",
"url": ""
},
{
"id": "5EVZ",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000044574-HSPA5",
"database": "HPA",
"url": ""
},
{
"id": "GRP78_HUMAN",
"database": "ZINC - Substances",
"url": ""
},
{
"id": "5F2R",
"database": "PDB",
"url": ""
},
{
"id": "3LDO",
"database": "PDB",
"url": ""
},
{
"id": "P11021",
"database": "ZINC target",
"url": ""
},
{
"id": "3LDL",
"database": "PDB",
"url": ""
},
{
"id": "5F0X",
"database": "PDB",
"url": ""
},
{
"id": "6DFM",
"database": "PDB",
"url": ""
},
{
"id": "7N1R",
"database": "PDB",
"url": ""
},
{
"id": "5E86",
"database": "PDB",
"url": ""
},
{
"id": "3193",
"database": "Guide to Pharmacology - Targets",
"url": ""
},
{
"id": "NP_005338.1",
"database": "RefSeq",
"url": ""
},
{
"id": "5E84",
"database": "PDB",
"url": ""
},
{
"id": "GRP78_HUMAN",
"database": "ZINC - Predictions - Purchasable",
"url": ""
},
{
"id": "5EY4",
"database": "PDB",
"url": ""
},
{
"id": "P11021",
"database": "PRO",
"url": ""
},
{
"id": "6CZ1",
"database": "PDB",
"url": ""
},
{
"id": "6ZMD",
"database": "PDB",
"url": ""
},
{
"id": "5E85",
"database": "PDB",
"url": ""
},
{
"id": "5EX5",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000044574",
"database": "OpenTargets",
"url": ""
},
{
"id": "6DO2",
"database": "PDB",
"url": ""
},
{
"id": "3LDP",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000324460",
"database": "Ensembl",
"url": ""
},
{
"id": "3IUC",
"database": "PDB",
"url": ""
},
{
"id": "GRP78_HUMAN",
"database": "ZINC - Biogenic",
"url": ""
},
{
"id": "ENSG00000044574",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000324173",
"database": "Ensembl",
"url": ""
},
{
"id": "6ASY",
"database": "PDB",
"url": ""
},
{
"id": "5EXW",
"database": "PDB",
"url": ""
},
{
"id": "P11021",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "3.6.4.10",
"database": "IntEnz",
"url": ""
}
]
},
{
"participant_id": "R-HSA-351322",
"participant_name": "HSPA5 [extracellular region]",
"crossref": [
{
"id": "6DO2",
"database": "PDB",
"url": ""
},
{
"id": "3LDL",
"database": "PDB",
"url": ""
},
{
"id": "5EXW",
"database": "PDB",
"url": ""
},
{
"id": "GRP78_HUMAN",
"database": "ZINC - Predictions - Purchasable",
"url": ""
},
{
"id": "P11021",
"database": "GeneCards",
"url": ""
},
{
"id": "6ZMD",
"database": "PDB",
"url": ""
},
{
"id": "GRP78_HUMAN",
"database": "ZINC - Substances",
"url": ""
},
{
"id": "GRP78_HUMAN",
"database": "ZINC - Biogenic",
"url": ""
},
{
"id": "5E86",
"database": "PDB",
"url": ""
},
{
"id": "6DWS",
"database": "PDB",
"url": ""
},
{
"id": "5EX5",
"database": "PDB",
"url": ""
},
{
"id": "3LDO",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000324173",
"database": "Ensembl",
"url": ""
},
{
"id": "5F1X",
"database": "PDB",
"url": ""
},
{
"id": "NP_005338.1",
"database": "RefSeq",
"url": ""
},
{
"id": "3.6.4.10",
"database": "IntEnz",
"url": ""
},
{
"id": "6DFM",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000324460",
"database": "Ensembl",
"url": ""
},
{
"id": "5EVZ",
"database": "PDB",
"url": ""
},
{
"id": "P11021",
"database": "PRO",
"url": ""
},
{
"id": "P11021",
"database": "UniProt",
"url": ""
},
{
"id": "6CZ1",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000044574-HSPA5",
"database": "HPA",
"url": ""
},
{
"id": "3IUC",
"database": "PDB",
"url": ""
},
{
"id": "7N1R",
"database": "PDB",
"url": ""
},
{
"id": "6ASY",
"database": "PDB",
"url": ""
},
{
"id": "P11021",
"database": "ZINC target",
"url": ""
},
{
"id": "ENSG00000044574",
"database": "OpenTargets",
"url": ""
},
{
"id": "6DFO",
"database": "PDB",
"url": ""
},
{
"id": "5E84",
"database": "PDB",
"url": ""
},
{
"id": "P11021",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "5F0X",
"database": "PDB",
"url": ""
},
{
"id": "3LDP",
"database": "PDB",
"url": ""
},
{
"id": "3LDN",
"database": "PDB",
"url": ""
},
{
"id": "5EY4",
"database": "PDB",
"url": ""
},
{
"id": "GRP78_HUMAN",
"database": "ZINC - Metabolites",
"url": ""
},
{
"id": "5E85",
"database": "PDB",
"url": ""
},
{
"id": "5F2R",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000044574",
"database": "Ensembl",
"url": ""
},
{
"id": "3193",
"database": "Guide to Pharmacology - Targets",
"url": ""
}
]
},
{
"participant_id": "R-HSA-381046",
"participant_name": "EIF2AK3 [endoplasmic reticulum membrane]",
"crossref": [
{
"id": "4X7O",
"database": "PDB",
"url": ""
},
{
"id": "4M7I",
"database": "PDB",
"url": ""
},
{
"id": "Q9NZJ5",
"database": "GeneCards",
"url": ""
},
{
"id": "15919",
"database": "Orphanet",
"url": ""
},
{
"id": "4G31",
"database": "PDB",
"url": ""
},
{
"id": "Q9NZJ5",
"database": "PRO",
"url": ""
},
{
"id": "NP_004827.4",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000172071",
"database": "OpenTargets",
"url": ""
},
{
"id": "4YZS",
"database": "PDB",
"url": ""
},
{
"id": "Q9NZJ5",
"database": "ZINC target",
"url": ""
},
{
"id": "Q9NZJ5",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "4X7K",
"database": "PDB",
"url": ""
},
{
"id": "E2AK3_HUMAN",
"database": "ZINC - Substances",
"url": ""
},
{
"id": "4X7H",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000172071",
"database": "Ensembl",
"url": ""
},
{
"id": "4X7L",
"database": "PDB",
"url": ""
},
{
"id": "8EQ9",
"database": "PDB",
"url": ""
},
{
"id": "8EQE",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000307235",
"database": "Ensembl",
"url": ""
},
{
"id": "8EQD",
"database": "PDB",
"url": ""
},
{
"id": "E2AK3_HUMAN",
"database": "ZINC - Predictions - Purchasable",
"url": ""
},
{
"id": "ENSG00000172071-EIF2AK3",
"database": "HPA",
"url": ""
},
{
"id": "7MF0",
"database": "PDB",
"url": ""
},
{
"id": "Q9NZJ5",
"database": "UniProt",
"url": ""
},
{
"id": "HMDBP09502",
"database": "HMDB Protein",
"url": ""
},
{
"id": "5SV7",
"database": "PDB",
"url": ""
},
{
"id": "4X7J",
"database": "PDB",
"url": ""
},
{
"id": "4X7N",
"database": "PDB",
"url": ""
},
{
"id": "4G34",
"database": "PDB",
"url": ""
},
{
"id": "2017",
"database": "Guide to Pharmacology - Targets",
"url": ""
},
{
"id": "ENST00000303236",
"database": "Ensembl",
"url": ""
}
]
},
{
"participant_id": "R-HSA-381076",
"participant_name": "ERN1 [endoplasmic reticulum membrane]",
"crossref": [
{
"id": "4Z7H",
"database": "PDB",
"url": ""
},
{
"id": "2HZ6",
"database": "PDB",
"url": ""
},
{
"id": "5HGI",
"database": "PDB",
"url": ""
},
{
"id": "4U6R",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000606895",
"database": "Ensembl",
"url": ""
},
{
"id": "6HV0",
"database": "PDB",
"url": ""
},
{
"id": "3P23",
"database": "PDB",
"url": ""
},
{
"id": "O75460",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENSG00000178607-ERN1",
"database": "HPA",
"url": ""
},
{
"id": "6W3E",
"database": "PDB",
"url": ""
},
{
"id": "4YZD",
"database": "PDB",
"url": ""
},
{
"id": "6XDF",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000178607",
"database": "Ensembl",
"url": ""
},
{
"id": "ERN1_HUMAN",
"database": "ZINC - FDA approved",
"url": ""
},
{
"id": "6SHC",
"database": "PDB",
"url": ""
},
{
"id": "6XDD",
"database": "PDB",
"url": ""
},
{
"id": "4YZC",
"database": "PDB",
"url": ""
},
{
"id": "ERN1_HUMAN",
"database": "ZINC - Predictions - Purchasable",
"url": ""
},
{
"id": "4YZ9",
"database": "PDB",
"url": ""
},
{
"id": "6HX1",
"database": "PDB",
"url": ""
},
{
"id": "ERN1_HUMAN",
"database": "ZINC - Investigational",
"url": ""
},
{
"id": "ENSP00000475519",
"database": "Ensembl",
"url": ""
},
{
"id": "O75460",
"database": "UniProt",
"url": ""
},
{
"id": "ERN1_HUMAN",
"database": "ZINC - Biogenic",
"url": ""
},
{
"id": "HMDBP08718",
"database": "HMDB Protein",
"url": ""
},
{
"id": "7BMK",
"database": "PDB",
"url": ""
},
{
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