{ "uniprot_canonical_ac": "P10635-1", "uniprot_ac": "P10635", "uniprot_id": "CP2D6_HUMAN", "mass": { "chemical_mass": 55769.0, "monoisotopic_mass": 55769.0 }, "refseq": { "ac": "NP_000097", "name": "cytochrome P450 2D6 isoform 1", "summary": "This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000097" }, "gene_names": [ { "name": "CYP2D6", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P10635", "id": "P10635" }, { "name": "CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000097", "id": "NP_000097" }, { "name": "CYP2D6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000097", "id": "NP_000097" }, { "name": "CYP2DL1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P10635", "id": "P10635" }, { "name": "LOC101929829", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P10635", "id": "P10635" }, { "name": "cyp2d6", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P10635", "id": "P10635" } ], "protein_names": [ { "name": "Cytochrome P450 2D6", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P10635" }, { "name": "1.14.14.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10635" }, { "name": "CYPIID6", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10635" }, { "name": "Cholesterol 25-hydroxylase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10635" }, { "name": "Cytochrome P450-DB1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10635" }, { "name": "Debrisoquine 4-hydroxylase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10635" }, { "name": "cytochrome P450 2D6 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000097", "id": "NP_000097" }, { "name": "debrisoquine 4-hydroxylase; microsomal monooxygenase; xenobiotic monooxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6; cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2; cholesterol 25-hydroxylase; cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2; nonfunctional cytochrome P450 2D6; cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1; cytochrome P450-DB1; cytochrome P450, family 2, subfamily D, polypeptide 6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000097", "id": "NP_000097" } ], "function": [ { "annotation": "A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids (PubMed:18698000, PubMed:19965576, PubMed:20972997, PubMed:21289075, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:18698000, PubMed:19965576, PubMed:20972997, PubMed:21289075, PubMed:21576599). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) (PubMed:19965576, PubMed:20972997). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:18698000, PubMed:21289075). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). Catalyzes the oxidative transformations of all-trans retinol to all-trans retinal, a precursor for the active form all-trans-retinoic acid (PubMed:10681376). Also involved in the oxidative metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635#function" }, { "database": "PubMed", "id": "18698000", "url": "https://glygen.org/publication/PubMed/18698000" }, { "database": "PubMed", "id": "21289075", "url": "https://glygen.org/publication/PubMed/21289075" }, { "database": "PubMed", "id": "10681376", "url": "https://glygen.org/publication/PubMed/10681376" }, { "database": "PubMed", "id": "21576599", "url": "https://glygen.org/publication/PubMed/21576599" }, { "database": "PubMed", "id": "19965576", "url": "https://glygen.org/publication/PubMed/19965576" }, { "database": "PubMed", "id": "20972997", "url": "https://glygen.org/publication/PubMed/20972997" }, { "database": "PubMed", "id": "16352597", "url": "https://glygen.org/publication/PubMed/16352597" } ] }, { "annotation": "Associations between Selected ADRB1 and CYP2D6 Gene Polymorphisms in Children with Ventricular and Supraventricular Arrhythmias. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000097" }, { "database": "PubMed", "id": "38138160", "url": "https://glygen.org/publication/PubMed/38138160" } ] }, { "annotation": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.", "evidence": [ { "database": "UniProtKB", "id": "H7BY38", "url": "https://www.uniprot.org/uniprot/H7BY38#function" }, { "database": "UniProtKB", "id": "RU368047", "url": "https://www.uniprot.org/uniprot/RU368047#function" }, { "database": "UniProtKB", "id": "Q38LG0", "url": "https://www.uniprot.org/uniprot/Q38LG0#function" }, { "database": "UniProtKB", "id": "A0A1B0GU72", "url": "https://www.uniprot.org/uniprot/A0A1B0GU72#function" }, { "database": "UniProtKB", "id": "Q6NWU0", "url": "https://www.uniprot.org/uniprot/Q6NWU0#function" }, { "database": "UniProtKB", "id": "A0A0G2JSD7", "url": "https://www.uniprot.org/uniprot/A0A0G2JSD7#function" }, { "database": "UniProtKB", "id": "A0A1B0GUD8", "url": "https://www.uniprot.org/uniprot/A0A1B0GUD8#function" }, { "database": "UniProtKB", "id": "C1ID54", "url": "https://www.uniprot.org/uniprot/C1ID54#function" } ] }, { "annotation": "Decreased Analgesic Effect of Tramadol in Japanese Patients with CYP2D6 Intermediate Metabolizers after Orthopedic Surgery.", "evidence": [ { "database": "RefSeq", "id": "NP_000097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000097" }, { "database": "PubMed", "id": "37394642", "url": "https://glygen.org/publication/PubMed/37394642" } ] }, { "annotation": "Effects of CYP2D6 allelic variants on therapy with tamsulosin in patients with benign prostatic hyperplasia. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000097" }, { "database": "PubMed", "id": "37656138", "url": "https://glygen.org/publication/PubMed/37656138" } ] }, { "annotation": "Novel Independent Trans- and Cis-Genetic Variants Associated with CYP2D6 Expression and Activity in Human Livers. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000097" }, { "database": "PubMed", "id": "38050015", "url": "https://glygen.org/publication/PubMed/38050015" } ] }, { "annotation": "Nrf2 Regulates the Expression of CYP2D6 by Inhibiting the Activity of Kruppel-Like Factor 9 (KLF9).", "evidence": [ { "database": "RefSeq", "id": "NP_000097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000097" }, { "database": "PubMed", "id": "37916628", "url": "https://glygen.org/publication/PubMed/37916628" } ] }, { "annotation": "This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].", "evidence": [ { "database": "RefSeq", "id": "NP_000097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000097" } ] } ], "disease": [ { "disease_id": "MONDO:0012148", "recommended_name": { "id": "MONDO:0012148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012148", "name": "obsolete drug metabolism, poor, CYP2D6-related", "description": "" }, "synonyms": [ { "id": "MONDO:0012148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012148", "name": "codeine sensitivity", "description": "" }, { "id": "MONDO:0012148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012148", "name": "debrisoquine sensitivity", "description": "" }, { "id": "MONDO:0012148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012148", "name": "drug metabolism, poor, CYP2D6-related", "description": "" }, { "id": "MONDO:0012148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012148", "name": "codeine, ultrarapid metabolism of", "description": "" }, { "id": "MONDO:0012148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012148", "name": "debrisoquine, poor metabolism of", "description": "" }, { "id": "MONDO:0012148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012148", "name": "debrisoquine, ultrarapid metabolism of", "description": "" }, { "id": "MONDO:0012148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012148", "name": "drug metabolism, ultrarapid, CYP2D6-related", "description": "" }, { "id": "MONDO:0012148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012148", "name": "nortriptyline, poor metabolism of", "description": "" }, { "id": "MONDO:0012148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012148", "name": "sparteine, poor metabolism of", "description": "" } ], "evidence": [ { "id": "608902", "database": "MIM", "url": "https://www.omim.org/entry/608902" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "78.28", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000100197", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000100197" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "66.54", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000100197", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000100197" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "72.01", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000100197", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000100197" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "69.93", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000100197", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000100197" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "71.5", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000100197", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000100197" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "80.98", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000100197", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000100197" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "97.53", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000100197", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000100197" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "80.56", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000100197", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000100197" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "73.41", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000100197", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000100197" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P10635", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P10635" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", 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"resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P10635", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P10635" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "P10635", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P10635" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that 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"https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the 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"https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "P10635", "url": 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This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "P10635", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P10635" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "P10635", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P10635" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P10635", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P10635" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "P10635", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P10635" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "P10635", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P10635" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Uterine cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:363", "evidence": [ { "database": "BioXpress", "id": "P10635", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P10635" } ], "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": 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"categories": [ "3D Structure" ] }, { "id": "3TBG", "url": "https://www.rcsb.org/structure/3TBG", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3TDA", "url": "https://www.rcsb.org/structure/3TDA", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4WNT", "url": "https://www.rcsb.org/structure/4WNT", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4WNU", "url": "https://www.rcsb.org/structure/4WNU", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4WNV", "url": "https://www.rcsb.org/structure/4WNV", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4WNW", "url": "https://www.rcsb.org/structure/4WNW", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4XRY", "url": "https://www.rcsb.org/structure/4XRY", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4XRZ", "url": "https://www.rcsb.org/structure/4XRZ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5TFT", "url": "https://www.rcsb.org/structure/5TFT", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5TFU", "url": "https://www.rcsb.org/structure/5TFU", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6CSB", "url": "https://www.rcsb.org/structure/6CSB", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6CSD", "url": "https://www.rcsb.org/structure/6CSD", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00067", "url": "http://pfam.xfam.org/family/PF00067", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P10635", "url": "https://pharos.nih.gov/targets/P10635", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_P10635", "url": "http://purl.obolibrary.org/obo/PR_P10635", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-211935", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211935", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-211958", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211958", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-211981", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211981", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-211999", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211999", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9027307", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9027307", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9749641", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9749641", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_000097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000097", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "39783", "url": "https://www.rhea-db.org/rhea/39783", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "42092", "url": "https://www.rhea-db.org/rhea/42092", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "49856", "url": "https://www.rhea-db.org/rhea/49856", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "49880", "url": "https://www.rhea-db.org/rhea/49880", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "49884", "url": "https://www.rhea-db.org/rhea/49884", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "50256", "url": "https://www.rhea-db.org/rhea/50256", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "52120", "url": "https://www.rhea-db.org/rhea/52120", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "52124", "url": "https://www.rhea-db.org/rhea/52124", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "53140", "url": "https://www.rhea-db.org/rhea/53140", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "53144", "url": "https://www.rhea-db.org/rhea/53144", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "53148", "url": "https://www.rhea-db.org/rhea/53148", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "53152", "url": "https://www.rhea-db.org/rhea/53152", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0G2JLK7", "url": "https://www.uniprot.org/uniprot/A0A0G2JLK7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JLK7-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JLK7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JSD7", "url": "https://www.uniprot.org/uniprot/A0A0G2JSD7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JSD7-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JSD7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1B0GU72", "url": "https://www.uniprot.org/uniprot/A0A1B0GU72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1B0GU72-1", "url": "https://www.uniprot.org/uniprot/A0A1B0GU72-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1B0GUD8", "url": "https://www.uniprot.org/uniprot/A0A1B0GUD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1B0GUD8-1", "url": "https://www.uniprot.org/uniprot/A0A1B0GUD8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1B0GV74", "url": "https://www.uniprot.org/uniprot/A0A1B0GV74", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1B0GV74-1", "url": "https://www.uniprot.org/uniprot/A0A1B0GV74-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C1ID54", "url": "https://www.uniprot.org/uniprot/C1ID54", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C1ID54-1", "url": "https://www.uniprot.org/uniprot/C1ID54-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7BY38", "url": "https://www.uniprot.org/uniprot/H7BY38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7BY38-1", "url": "https://www.uniprot.org/uniprot/H7BY38-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P10635-1", "url": "https://www.uniprot.org/uniprot/P10635-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P10635-2", "url": "https://www.uniprot.org/uniprot/P10635-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q38LG0", "url": "https://www.uniprot.org/uniprot/Q38LG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q38LG0-1", "url": "https://www.uniprot.org/uniprot/Q38LG0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6NWU0", "url": "https://www.uniprot.org/uniprot/Q6NWU0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6NWU0-1", "url": "https://www.uniprot.org/uniprot/Q6NWU0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR", "length": 497, "header": "sp|P10635-1|CP2D6_HUMAN Isoform 1 of Cytochrome P450 2D6 OS=Homo sapiens OX=9606 GN=CYP2D6 PE=1 SV=2 CANONICAL=P10635-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JLK7-1", "url": "", "sequence": { "sequence": "MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYSPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVPR", "length": 446, "header": "tr|A0A0G2JLK7-1|A0A0G2JLK7_HUMAN Computationally mapped isoform of Cytochrome P450 2D6 OS=Homo sapiens OX=9606 GN=CYP2D6 PE=1 SV=1 CANONICAL=P10635-1" }, "locus": { "chromosome": "HSCHR22_2_CTG1", "start_pos": 65275, "end_pos": 61061, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000606649.2", "url": "https://www.ensembl.org/id/ENST00000606649.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000475794.1", "url": "https://www.ensembl.org/id/ENSP00000475794.1" } ] } }, { "isoform_ac": "A0A0G2JSD7-1", "url": "", "sequence": { "sequence": "MHRRQRWAARYSPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQQGGRVQAGAHPIVGTHVCPGRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVPR", "length": 494, "header": "tr|A0A0G2JSD7-1|A0A0G2JSD7_HUMAN Computationally mapped isoform of Cytochrome P450 OS=Homo sapiens OX=9606 GN=CYP2D6 PE=1 SV=1 CANONICAL=P10635-1" }, "locus": { "chromosome": "HSCHR22_5_CTG1", "start_pos": 16291, "end_pos": 12143, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000625898.2", "url": "https://www.ensembl.org/id/ENST00000625898.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000487558.1", "url": "https://www.ensembl.org/id/ENSP00000487558.1" } ] } }, { "isoform_ac": "A0A1B0GU72-1", "url": "", "sequence": { "sequence": "MHRRQRWAARYSPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREAMVTRGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQQGGRVQAGAHPIVGTHVCPGRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVPR", "length": 494, "header": "tr|A0A1B0GU72-1|A0A1B0GU72_HUMAN Computationally mapped isoform of Cytochrome P450 OS=Homo sapiens OX=9606 GN=CYP2D6 PE=1 SV=1 CANONICAL=P10635-1" }, "locus": { "chromosome": "HSCHR22_8_CTG1", "start_pos": 8466, "end_pos": 4318, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000636361.1", "url": "https://www.ensembl.org/id/ENST00000636361.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000489990.1", "url": "https://www.ensembl.org/id/ENSP00000489990.1" } ] } }, { "isoform_ac": "A0A1B0GUD8-1", "url": "", "sequence": { "sequence": "LRRRFGDVFSLQLAWTPVVVLNGLAAVREAMVTRGEDTADRPPVPITQILGFGPRSQGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKWWLTCSLPGW", "length": 180, "header": "tr|A0A1B0GUD8-1|A0A1B0GUD8_HUMAN Computationally mapped isoform of Cytochrome P450 OS=Homo sapiens OX=9606 GN=CYP2D6 PE=1 SV=1 CANONICAL=P10635-1" }, "locus": { "chromosome": "HSCHR22_8_CTG1", "start_pos": 7650, "end_pos": 5646, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000636910.1", "url": "https://www.ensembl.org/id/ENST00000636910.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000490065.1", "url": "https://www.ensembl.org/id/ENSP00000490065.1" } ] } }, { "isoform_ac": "A0A1B0GV74-1", "url": "", "sequence": { "sequence": "MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYSPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREAMVTRGEDTADRPPVPITQILGFGPRSQGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVPR", "length": 446, "header": "tr|A0A1B0GV74-1|A0A1B0GV74_HUMAN Computationally mapped isoform of Cytochrome P450 2D6 OS=Homo sapiens OX=9606 GN=CYP2D6 PE=1 SV=1 CANONICAL=P10635-1" }, "locus": { "chromosome": "HSCHR22_8_CTG1", "start_pos": 8532, "end_pos": 4318, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000637987.1", "url": "https://www.ensembl.org/id/ENST00000637987.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000490398.1", "url": "https://www.ensembl.org/id/ENSP00000490398.1" } ] } }, { "isoform_ac": "C1ID54-1", "url": "", "sequence": { "sequence": "MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYSPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREAMVTRGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVPR", "length": 497, "header": "tr|C1ID54-1|C1ID54_HUMAN Computationally mapped isoform of Cytochrome P450 OS=Homo sapiens OX=9606 GN=CYP2D6 PE=1 SV=1 CANONICAL=P10635-1" }, "locus": { "chromosome": "HSCHR22_8_CTG1", "start_pos": 8532, "end_pos": 4318, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000646114.2", "url": "https://www.ensembl.org/id/ENST00000646114.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000493632.1", "url": "https://www.ensembl.org/id/ENSP00000493632.1" } ] } }, { "isoform_ac": "H7BY38-1", "url": "", "sequence": { "sequence": "LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKWWLTCSLPGW", "length": 180, "header": "tr|H7BY38-1|H7BY38_HUMAN Computationally mapped isoform of Cytochrome P450 OS=Homo sapiens OX=9606 GN=CYP2D6 PE=1 SV=1 CANONICAL=P10635-1" }, "locus": { "chromosome": "HSCHR22_7_CTG1", "start_pos": 23498, "end_pos": 21494, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000635505.1", "url": "https://www.ensembl.org/id/ENST00000635505.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000488991.1", "url": "https://www.ensembl.org/id/ENSP00000488991.1" } ] } }, { "isoform_ac": "P10635-1", "url": "", "sequence": { 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"UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "reference": [ { "type": "PubMed", "id": "10064570", "url": "https://glygen.org/publication/PubMed/10064570" } ] }, { "title": "Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells.", "journal": "Molecular pharmacology", "date": "1999", "authors": "Cui Y, Konig J, Buchholz JK, Spring H, Leier I, Keppler D", "evidence": [ { "database": "Reactome", "id": "R-HSA-9749641", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9749641" } ], "reference": [ { "type": "PubMed", "id": "10220572", "url": "https://glygen.org/publication/PubMed/10220572" } ] }, { "title": "Specific dehydrogenation of 3-methylindole and epoxidation of naphthalene by recombinant human CYP2F1 expressed in lymphoblastoid cells.", "journal": "Drug metabolism and disposition: the biological fate of chemicals", "date": "1999", "authors": "Lanza DL, Code E, Crespi CL, Gonzalez FJ, Yost GS", "evidence": [ { "database": "Reactome", "id": "R-HSA-211981", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211981" } ], "reference": [ { "type": "PubMed", "id": "10383923", "url": "https://glygen.org/publication/PubMed/10383923" } ] }, { "title": "Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids.", "journal": "Biochimica et biophysica acta", "date": "1999", "authors": "Vessey DA, Kelley M, Warren RS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9749641", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9749641" } ], "reference": [ { "type": "PubMed", "id": "10434065", "url": "https://glygen.org/publication/PubMed/10434065" } ] }, { "title": "Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes.", "journal": "Drug metabolism and disposition: the biological fate of chemicals", "date": "2000-03", "authors": "Chen H, Howald W N, Juchau M R", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "reference": [ { "type": "PubMed", "id": "10681376", "url": "https://glygen.org/publication/PubMed/10681376" } ] }, { "title": "Cytochrome P450 2E1 is the primary enzyme responsible for low-dose carbon tetrachloride metabolism in human liver microsomes.", "journal": "Chemico-biological interactions", "date": "2000", "authors": "Zangar RC, Benson JM, Burnett VL, Springer DL", "evidence": [ { "database": "Reactome", "id": "R-HSA-211999", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211999" } ], "reference": [ { "type": "PubMed", "id": "10731522", "url": "https://glygen.org/publication/PubMed/10731522" } ] }, { "title": "Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation.", "journal": "Clinical pharmacology and therapeutics", "date": "2000", "authors": "Manyike PT, Kharasch ED, Kalhorn TF, Slattery JT", "evidence": [ { "database": "Reactome", "id": "R-HSA-211999", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211999" } ], "reference": [ { "type": "PubMed", "id": "10741631", "url": "https://glygen.org/publication/PubMed/10741631" } ] }, { "title": "cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450.", "journal": "Molecular pharmacology", "date": "2001", "authors": "Domanski TL, Finta C, Halpert JR, Zaphiropoulos PG", "evidence": [ { "database": "Reactome", "id": "R-HSA-211958", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211958" } ], "reference": [ { "type": "PubMed", "id": "11160876", "url": "https://glygen.org/publication/PubMed/11160876" } ] }, { "title": "cDna cloning and expression of CYP4F12, a novel human cytochrome P450.", "journal": "Biochemical and biophysical research communications", "date": "2001", "authors": "Bylund J, Bylund M, Oliw EH", "evidence": [ { "database": "Reactome", "id": "R-HSA-211935", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211935" } ], "reference": [ { "type": "PubMed", "id": "11162607", "url": "https://glygen.org/publication/PubMed/11162607" } ] }, { "title": "Isolation of a family of organic anion transporters from human liver and kidney.", "journal": "Biochemical and biophysical research communications", "date": "2001", "authors": "Sun W, Wu RR, van Poelje PD, Erion MD", "evidence": [ { "database": "Reactome", "id": "R-HSA-9749641", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9749641" } ], "reference": [ { "type": "PubMed", "id": "11327718", "url": "https://glygen.org/publication/PubMed/11327718" } ] }, { "title": "Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3).", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Zelcer N, Saeki T, Reid G, Beijnen JH, Borst P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9749641", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9749641" } ], "reference": [ { "type": "PubMed", "id": "11581266", "url": "https://glygen.org/publication/PubMed/11581266" } ] }, { "title": "Cytochrome P450 isozymes involved in the metabolism of phenol, a benzene metabolite.", "journal": "Toxicology letters", "date": "2001", "authors": "Powley MW, Carlson GP", "evidence": [ { "database": "Reactome", "id": "R-HSA-211999", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211999" } ], "reference": [ { "type": "PubMed", "id": "11701230", "url": "https://glygen.org/publication/PubMed/11701230" } ] }, { "title": "Cytochrome P450 oxidations in the generation of reactive electrophiles: epoxidation and related reactions.", "journal": "Archives of biochemistry and biophysics", "date": "2003", "authors": "Guengerich FP", "evidence": [ { "database": "Reactome", "id": "R-HSA-211981", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211981" } ], "reference": [ { "type": "PubMed", "id": "12464245", "url": "https://glygen.org/publication/PubMed/12464245" } ] }, { "title": "Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria.", "journal": "Journal of biochemical and molecular toxicology", "date": "2003", "authors": "Vessey DA, Lau E, Kelley M, Warren RS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9749641", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9749641" } ], "reference": [ { "type": "PubMed", "id": "12616642", "url": "https://glygen.org/publication/PubMed/12616642" } ] }, { "title": "Role of polymorphic human CYP2B6 in cyclophosphamide bioactivation.", "journal": "The pharmacogenomics journal", "date": "2003", "authors": "Xie HJ, Yasar U, Lundgren S, Griskevicius L, Terelius Y, Hassan M, Rane A", "evidence": [ { "database": "Reactome", "id": "R-HSA-211981", "url": 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the official journal of the Association for Ocular Pharmacology and Therapeutics", "date": "2004", "authors": "Ashkar S, Mesentsev A, Zhang WX, Mastyugin V, Dunn MW, Laniado-Schwartzman M", "evidence": [ { "database": "Reactome", "id": "R-HSA-211935", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211935" } ], "reference": [ { "type": "PubMed", "id": "15006160", "url": "https://glygen.org/publication/PubMed/15006160" } ] }, { "title": "Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7-hydroxylation.", "journal": "Archives of biochemistry and biophysics", "date": "2004", "authors": "He XY, Shen J, Hu WY, Ding X, Lu AY, Hong JY", "evidence": [ { "database": "Reactome", "id": "R-HSA-211981", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211981" } ], "reference": [ { "type": "PubMed", "id": "15196988", "url": "https://glygen.org/publication/PubMed/15196988" } ] }, { "title": "Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes.", "journal": "European journal of clinical pharmacology", "date": "2004", "authors": "Kim KA, Chung J, Jung DH, Park JY", "evidence": [ { "database": "Reactome", "id": "R-HSA-211981", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211981" } ], "reference": [ { "type": "PubMed", "id": "15365656", "url": "https://glygen.org/publication/PubMed/15365656" } ] }, { "title": "Increased levels of aflatoxin-albumin adducts are associated with CYP3A5 polymorphisms in The Gambia, West Africa.", "journal": "Pharmacogenetics", "date": "2004", "authors": "Wojnowski L, Turner PC, Pedersen B, Hustert E, Brockmoller J, Mendy M, Whittle HC, Kirk G, Wild CP", "evidence": [ { "database": "Reactome", "id": "R-HSA-211981", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211981" } ], "reference": [ { "type": "PubMed", "id": "15454734", "url": "https://glygen.org/publication/PubMed/15454734" } ] }, { "title": "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.", "journal": "Pharmacogenomics", "date": "2004", "authors": "Solus JF, Arietta BJ, Harris JR, Sexton DP, Steward JQ, McMunn C, Ihrie P, Mehall JM, Edwards TL, Dawson EP", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "reference": [ { "type": "PubMed", "id": "15469410", "url": "https://glygen.org/publication/PubMed/15469410" } ] }, { "title": "CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer.", "journal": "Cancer research", "date": "2004", "authors": "Zeigler-Johnson C, Friebel T, Walker AH, Wang Y, Spangler E, Panossian S, Patacsil M, Aplenc R, Wein AJ, Malkowicz SB, Rebbeck TR", "evidence": [ { "database": "Reactome", "id": "R-HSA-211958", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211958" } ], 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"http://www.informatics.jax.org/homology/45933485", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P10634-1", "protein_name": "Cytochrome P450 2D26", "gene_name": "Cyp2d26", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGLLIGDDLWAVVIFTAIFLLLVDLVHRHKFWTAHYPPGPVPLPGLGNLLQVDFENMPYSLYKLRSRYGDVFSLQIAWKPVVVINGLKAVRELLVTYGEDTADRPLLPIYNHLGYGNKSKGVVLAPYGPEWREQRRFSVSTLRDFGVGKKSLEQWVTEEAGHLCDTFAKEAEHPFNPSILLSKAVSNVIASLVYARRFEYEDPFFNRMLKTLKESFGEDTGFMAEVLNAIPILLQIPGLPGKVFPKLNSFIALVDKMLIEHKKSWDPAQPPRDMTDAFLAEMQKAKGNPESSFNDENLRLVVIDLFMAGMVTTSTTLSWALLLMILHPDVQRRVHEEIDEVIGQVRRPEMADQARMPFTNAVIHEVQRFADIVPTNIPHMTSRDIKFQGFLIPKGTTLIPNLSSVLKDETVWEKPLRFHPEHFLDAQGNFVKHEAFMPFSAGRRACLGEPLARMELFLFFTCLLQRFSFSVLAGRPRPSTHGVYALPVTPQPYQLCAVAR", "length": 500 }, "evidence": [ { "id": "45933484", "url": "http://www.informatics.jax.org/homology/45933484", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P11714-1", "protein_name": "Cytochrome P450 2D9", "gene_name": "Cyp2d9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELLTGTDLWPVAIFTVIFILLVDLTHQRQRWTSRYPPGPVPWPVLGNLLQVDLGNMPYSLYKLQNRYGDVFSLQMAWKPMVVINGLKAMKEMLLTCGEDTADRPPVPIFEYLGVKPGSQGVVLAPYGPEWREQRRFSVSTLRNFGLGKKSLEDWVTKEANHLCDAFTAQAGQPINPNPMLNKSTCNVIASLIFARRFEYEDPFLIRMLKVLEQSLTEVSGLIPEVLNAFPILLRIPRLADKALQGQKSFIAILDNLLTENRTTWDPVQAPRNLTDAFLAEIEKAKGNPESSFNDENLLMVVRDLFGAGMLTTSTTLSWALMLMILHPDVQRRVQQEIDEVIGQVRHPEMADQAHMPYTNAVIHEVQRFGDIVPVNLPRITSHDIEVQDFLIPKGTILLPNMSSMLKDESVWEKPLRFHPEHFLDAQGHFVKPEAFMPFSAGRRSCLGEALARMELFLFFTCLLQRFSFSVPDGQPQPSNSGVYGILVAPSPYQLCAVVRDQGH", "length": 504 }, "evidence": [ { "id": "45933486", "url": "http://www.informatics.jax.org/homology/45933486", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P12938-1", "protein_name": "Cytochrome P450 2D3", "gene_name": "Cyp2d3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MELLAGTGLWPMAIFTVIFILLVDLMHRRQRWTSRYPPGPVPWPVLGNLLQVDLCNMPYSMYKLQNRYGDVFSLQMGWKPVVVINGLKAVQELLVTCGEDTADRPEMPIFQHIGYGHKAKGVVLAPYGPEWREQRRFSVSTLRNFGVGKKSLEQWVTDEASHLCDALTAEAGRPLDPYTLLNKAVCNVIASLIYARRFDYGDPDFIKVLKILKESMGEQTGLFPEVLNMFPVLLRIPGLADKVFPGQKTFLTMVDNLVTEHKKTWDPDQPPRDLTDAFLAEIEKAKGNPESSFNDANLRLVVNDLFGAGMVTTSITLTWALLLMILHPDVQCRVQQEIDEVIGQVRHPEMADQAHMPFTNAVIHEVQRFADIVPMNLPHKTSRDIEVQGFLIPKGTTLIPNLSSVLKDETVWEKPLRFHPEHFLDAQGNFVKHEAFMPFSAGRRACLGEPLARMELFLFFTCLLQRFSFSVPTGQPRPSDYGVFAFLLSPSPYQLCAFKR", "length": 500 }, "evidence": [ { "id": "45933488", "url": "http://www.informatics.jax.org/homology/45933488", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P12939-1", "protein_name": "Cytochrome P450 2D10", "gene_name": "Cyp2d10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MELLNGTGLWPMAIFTVIFILLVDLMHRHQRWTSRYPPGPVPWPVLGNLLQVDPSNMPYSMYKLQHRYGDVFSLQMGWKPMVIVNRLKAVQEVLVTHGEDTADRPPVPIFKCLGVKPRSQGVVFASYGPEWREQRRFSVSTLRTFGMGKKSLEEWVTKEAGHLCDAFTAQNGRSINPKAMLNKALCNVIASLIFARRFEYEDPYLIRMLTLVEESLIEVSGFIPEVLNTFPALLRIPGLADKVFQGQKTFMAFLDNLLAENRTTWDPAQPPRNLTDAFLAEVEKAKGNPESSFNDENLRMVVVDLFTAGMVTTATTLTWALLLMILYPDVQRRVQQEIDEVIGQVRCPEMTDQAHMPYTNAVIHEVQRFGDIAPLNLPRITSCDIEVQDFVIPKGTTLIINLSSVLKDETVWEKPLRFHPEHFLDAQGNFVKHEAFMPFSAGRRACLGEPLARMELFLFFTCLLQHFSFSVPAGQPRPSTLGNFAISVAPLPYQLCAAVREQGH", "length": 504 }, "evidence": [ { "id": "45933487", "url": "http://www.informatics.jax.org/homology/45933487", "database": "MGI" }, { "id": "45933486", "url": "http://www.informatics.jax.org/homology/45933486", "database": "MGI" }, { "id": "45933491", "url": "http://www.informatics.jax.org/homology/45933491", "database": "MGI" }, { "id": "45933490", "url": "http://www.informatics.jax.org/homology/45933490", "database": "MGI" }, { "id": "45933485", "url": "http://www.informatics.jax.org/homology/45933485", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P24456-1", "protein_name": "Cytochrome P450 2D10", "gene_name": "Cyp2d10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELLTGAGLWSVAIFTVIFILLVDLMHRHQRWTSRYPPGPVPWPVLGNLLQVDLDNMPYSLYKLQNRYGDVFSLQMGWKPMVVINGLKAMKEVLLTCGEDTADRPQVPIFEYLGVKPGSQGVVLAPYGPEWREQRRFSVSTLRNFGLGKKSLEDWVTKEARHLCDAFTAQAGQPINPNTMLNNAVCNVIASLIFARRFEYEDPYLIRMQKVLEDSLTEISGLIPEVLNMFPILLRIPGLPGKVFQGQKSLLAIVENLLTENRNTWDPDQPPRNLTDAFLAEIEKVKGNAESSFNDENLRMVVLDLFTAGMVTTSTTLSWALLLMILHPDVQRRVQQEIDAVIGQVRHPEMADQARMPYTNAVIHEVQRFGDIAPLNLPRITSRDIEVQDFLIPKGSILIPNMSSVLKDETVWEKPLRFHPEHFLDAQGHFVKPEAFMPFSAGRRSCLGEPLARMELFLFFTCLLQHFSFSVPNGQPRPRNLGVFPFPVAPYPYQLCAVMREQGH", "length": 504 }, "evidence": [ { "id": "45933485", "url": "http://www.informatics.jax.org/homology/45933485", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P24457-1", "protein_name": "Cytochrome P450 2D11", "gene_name": "Cyp2d11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELLTGAGLWSVAIFTVIFILLVDLMHRHQHWTSRCPPGPVPWPVLGNLLQVDLGNMPYSLYKLQNRYGDVFSLQMGWKPMVVINGLKAMKEVLLTCGEDTADRPQVPIFEYLGVKPGSQGVVLAPYGPEWQEQRRFSVSTLRNFGLGKKSLEDWVTKEARHLCDAFTAQAGQSINPNTMLNNAVCNVIASLIFARRFEYEDPYLIRMLKMLKECFTEISGFIPGVLNEFPIFLRIPGLADMVFQGQKSFMAILDNLLTENRTTWDPDQPPRNLTDAFLAEIEKAKGNPESSFNDENLRMVVGDLFTAGMVTTSTTLSWALLLMILHPDVQRRVQQEIDAVIGQVQHPEMADQARMPYTNAVIHEVQRFGDIAPLPLPRITSRDIEVQDFLVTKGSTLIPNMSSVLKDETVWEKPLRFHPEHFLDAQGHFVKPEAFMPFSAGHRSCLGEALARMELFLFFTCLLQRFSISVPDGQPQPSNYRVHAIPVAPFPYQLCAVMREQGH", "length": 504 }, "evidence": [ { "id": "45933487", "url": "http://www.informatics.jax.org/homology/45933487", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q64680-1", "protein_name": "Cytochrome P450 2D4", "gene_name": "Cyp2d4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRMPTGSELWPIAIFTIIFLLLVDLMHRRQRWTSRYPPGPVPWPVLGNLLQIDFQNMPAGFQKLRCRFGDLFSLQLAFESVVVLNGLPALREALVKYSEDTADRPPLHFNDQSGFGPRSQGVVLARYGPAWRQQRRFSVSTFRHFGLGKKSLEQWVTEEARCLCAAFADHSGFPFSPNTLLDKAVCNVIASLLFACRFEYNDPRFIRLLDLLKDTLEEESGFLPMLLNVFPMLLHIPGLLGKVFSGKKAFVAMLDELLTEHKVTWDPAQPPRDLTDAFLAEVEKAKGNPESSFNDENLRVVVADLFMAGMVTTSTTLTWALLFMILRPDVQCRVQQEIDEVIGQVRRPEMADQARMPFTNAVIHEVQRFADILPLGVPHKTSRDIEVQGFLIPKGTTLIINLSSVLKDETVWEKPLRFHPEHFLDAQGNFVKHEAFMPFSAGRRACLGEPLARMELFLFFTCLLQRFSFSVPAGQPRPSNYGVFGALTTPRPYQLCASPR", "length": 500 }, "evidence": [ { "id": "45933489", "url": "http://www.informatics.jax.org/homology/45933489", "database": "MGI" }, { "id": "P10635", "url": "https://omabrowser.org/oma/group/P10635/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6P8N9-1", "protein_name": "Cytochrome P450, family 2, subfamily d, polypeptide 40", "gene_name": "Cyp2d40", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELLTGTDLWPVAIFTVIFILLVDLLHRRQRWTSRYPPGPVPWPVLGNLLQVDLDNMPYSFYKVVKMFPIVLRIPGLADKIFPGQKTFLTMVDKLVTEHKRTWDPDQPPRDLTDAFMAEMETAKGNPESSFNEANLRLVVLDLFGGGIVTTSATLTWALLLMILHPDVQRRVQEEIDEVIGQARRPEMADQARMPYTNAVIHEVQRFADIAPMTLPHRTSCDIEVQGFLIPKGTTLICNLSSVLKDETVWEKPLRFYPEHFLDAQGHFVKPEAFMPFSAGRRACLGEPLVRMELFLFFTCLLQRFSFSVPDGQPLPSDYGIYSMVVSPAPYQLCAVVR", "length": 338 }, "evidence": [ { "id": "45933488", "url": "http://www.informatics.jax.org/homology/45933488", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8BVD2-1", "protein_name": "Cytochrome P450", "gene_name": "Cyp2d12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELLTGTDLWSVAIFTVIFILLVDLMHRRQSWTSCYPPGPVPWPVLGNLLQVDLNNMPYSLYKLQNRYGDVFSLQMAWKPMVVINRMKAMKEVLLTCGEDTADRPPVPIFEHLGFKPRSQGMIFAPYGPEWREQRRFSLSSLRNFGLGRKSLEEWVIKEAGHLCDAFTTQAGQYINPNTMLKKATCNVIASLIFARRFEYEDPYLIRMLKVLEDSLTELSGLIPEVINTFPILLHIPRLADKFLQSQKSFIAIVDNLLTENRTTWDPAQSPRNLTDAFLAEIEKAKGNPESSFNDENLRMVVIDLFTAGILTTSTTLSWALLLMILHPDVQRRVQQEIDEVIGQVRHPEMADQAHMPYTNAVIHEVQRFGDIVPLHLPRITSRDIEVQDFLIPKGTILLPNMSSVHMDDTVWEKPLRFHPEHFLDAQGHFVKHEAFITFSAGRRSCLGEPLARMELFLFFTCLLQRFSFSVPDGQPQPSDHRVFSIMVAPSPYQLCAVIREQGH", "length": 504 }, "evidence": [ { "id": "45933491", "url": "http://www.informatics.jax.org/homology/45933491", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8CIM7-1", "protein_name": "Cytochrome P450 2D26", "gene_name": "Cyp2d26", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVGDDLWAVVIFTAIFLLLVDLVHRRQRWTACYPPGPVPFPGLGNLLQVDFENIPYSFYKLQNRYGNVFSLQMAWKPVVVVNGLKAVRELLVTYGEDTSDRPLMPIYNHIGYGHKSKGVILAPYGPEWREQRRFSVSTLRDFGLGKKSLEQWVTEEAGHLCDAFTKEAEHPFNPSPLLSKAVSNVIASLIYARRFEYEDPFFNRMLKTLKESLGEDTGFVGEVLNAIPMLLHIPGLPDKAFPKLNSFIALVNKMLIEHDLTWDPAQPPRDLTDAFLAEVEKAKGNPESSFNDKNLRIVVIDLFMAGMVTTSTTLSWALLLMILHPDVQRRVHQEIDEVIGHVRHPEMADQARMPYTNAVIHEVQRFADIVPTNLPHMTSRDIKFQDFFIPKGTTLIPNLSSVLKDETVWEKPLRFYPEHFLDAQGHFVKHEAFMPFSAGRRSCLGEPLARMELFLFFTCLLQRFSFSVPDGQPRPSDYGIYTMPVTPEPYQLCAVAR", "length": 500 }, "evidence": [ { "id": "45933484", "url": "http://www.informatics.jax.org/homology/45933484", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9JKY7-1", "protein_name": "Cytochrome P450", "gene_name": "Cyp2d22", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRLPTGAELWPIAIFTVIFLILVNLMHWRQRWTAHYPPGPMPWPVLGNLLHMDFQNMPAGFQKLRGRYGDLFSLQLASESVVVLNGLTALREALVKHSEDTADRPPLHFNDLLGFGPRSQGIVLARYGPAWRQQRRFSVSTMHHFGLGKKSLEQWVTEEARCLCAAFADHTGHPFSPNTLLDKAVCNVIASLLYACRFEYDDPRFIRLLGLLKETLKEEAGFLPMFLNVFPMLLRIPGLVGKVFPGKRAFVTMLDELLAEHKTTWDPTQPPRDLTDAFLAEVEKAKGNPESSFNDENLRTVVGDLFSAGMVTTSTTLSWALMLMILHPDVQRRVQQEIDEVIGQVQCPEMADQARMPYTNAVIHEVQRFADILPLGVPHKTSRDIELQGFLIPKGTTLITNLSSALKDETVWEKPLCFHPEHFLDAQGHFVKPEAFMPFSAGRRSCLGEPLARMELFLFFTCLLQRFSISVPDGQPQPSDHGVFRALTTPCPYQLCALPR", "length": 500 }, "evidence": [ { "id": "45933489", "url": "http://www.informatics.jax.org/homology/45933489", "database": "MGI" }, { "id": "P10635", "url": "https://omabrowser.org/oma/group/P10635/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 10, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "id": "GO:0016712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016712", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "monooxygenase activity", "id": "GO:0004497", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004497", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "anandamide 8,9 epoxidase activity", "id": "GO:0062187", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062187", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "anandamide 11,12 epoxidase activity", "id": "GO:0062188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062188", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "anandamide 14,15 epoxidase activity", "id": "GO:0062189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062189", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "aromatase activity", "id": "GO:0070330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070330", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "id": "GO:0016705", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016705", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 17, "go_terms": [ { "name": "estrogen metabolic process", "id": "GO:0008210", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008210", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "monoterpenoid metabolic process", "id": "GO:0016098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016098", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "heterocycle metabolic process", "id": "GO:0046483", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046483", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "cholesterol metabolic process", "id": "GO:0008203", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008203", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "retinol metabolic process", "id": "GO:0042572", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042572", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "xenobiotic metabolic process", "id": "GO:0006805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006805", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "xenobiotic catabolic process", "id": "GO:0042178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042178", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "oxidative demethylation", "id": "GO:0070989", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070989", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "steroid metabolic process", "id": "GO:0008202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008202", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "long-chain fatty acid biosynthetic process", "id": "GO:0042759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042759", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "arachidonic acid metabolic process", "id": "GO:0019369", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019369", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "isoquinoline alkaloid metabolic process", "id": "GO:0033076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033076", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "negative regulation of binding", "id": "GO:0051100", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051100", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "negative regulation of cellular organofluorine metabolic process", "id": "GO:0090350", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090350", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "coumarin metabolic process", "id": "GO:0009804", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009804", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "alkaloid metabolic process", "id": "GO:0009820", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009820", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" }, { "name": "alkaloid catabolic process", "id": "GO:0009822", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009822", "evidence": [ { "database": "UniProtKB", "id": "P10635", "url": "https://www.uniprot.org/uniprot/P10635" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 398, "end_pos": 400, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "39783", "name": "", "equation": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P08683-1", "P24470-1", "P10635-1", "P51589-1", "P10632-1", "Q91WL5-1", "E9Q5K4-1", "A2A974-1" ], "evidence": [ { "id": "39783", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39783" } ] }, { "id": "42092", "name": "", "equation": "all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P04799-1", "Q64678-1", "P10635-1", "P08684-1", "P04798-1", "P05177-1", "Q16678-1", "P20815-1", "P00186-1", "P00184-1", "Q64429-1" ], "evidence": [ { "id": "42092", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/42092" } ] }, { "id": "49856", "name": "", "equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04799-1", "Q64678-1", "P08683-1", "P24470-1", "P10635-1", "P08684-1", "P51589-1", "P04798-1", "P05177-1", "P10632-1", "P11712-1", "Q86W10-1", "P00186-1", "P00184-1", "P56657-1" ], "evidence": [ { "id": "49856", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/49856" } ] }, { "id": "49880", "name": "", "equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "Q64678-1", "P08683-1", "P24470-1", "P10635-1", "P51589-1", "P04798-1", "P33261-1", "Q16678-1", "P10632-1", "P11712-1", "P00184-1", "Q64429-1", "E9Q5K4-1" ], "evidence": [ { "id": "49880", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/49880" } ] }, { "id": "49884", "name": "", "equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "Q64678-1", "P08683-1", "P24470-1", "P10635-1", "P51589-1", "P04798-1", "P33261-1", "Q16678-1", "P11712-1", "P00184-1", "Q64429-1", "E9Q5K4-1" ], "evidence": [ { "id": "49884", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/49884" } ] }, { "id": "50256", "name": "", "equation": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04799-1", "P10635-1", "P08684-1", "P05177-1", "P11712-1", "P00186-1" ], "evidence": [ { "id": "50256", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/50256" } ] }, { "id": "52120", "name": "", "equation": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P04799-1", "P10635-1", "P08684-1", "P51589-1", "P04798-1", "P05177-1", "P33261-1", "P10632-1", "P00186-1", "P00184-1" ], "evidence": [ { "id": "52120", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52120" } ] }, { "id": "52124", "name": "", "equation": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P10635-1", "P08684-1", "P51589-1", "P04798-1", "P33261-1", "P10632-1", "P00184-1" ], "evidence": [ { "id": "52124", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52124" } ] }, { "id": "53140", "name": "", "equation": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P10635-1", "P08684-1", "P20813-1" ], "evidence": [ { "id": "53140", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53140" } ] }, { "id": "53144", "name": "", "equation": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P10635-1", "P08684-1", "P20813-1" ], "evidence": [ { "id": "53144", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53144" } ] }, { "id": "53148", "name": "", "equation": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8K4D6-1", "P10635-1", "P08684-1", "P20813-1", "Q8N118-1", "Q6A152-1" ], "evidence": [ { "id": "53148", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53148" } ] }, { "id": "53152", "name": "", "equation": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P10635-1" ], "evidence": [ { "id": "53152", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53152" } ] }, { "id": "R-HSA-143468", "name": "MEOS oxidizes ethanol to acetaldehyde", "equation": "", "summary": "The MEOS (microsomal ethanol oxidizing system) is an accessory pathway in the liver which increases in activity on chronic alcohol induction. The MEOS utilizes a cytochrome P450 which has since been deciphered to be CYP2E1, an ethanol-inducible form of P450. CYP2E1 also increases acetaldehyde formation and free radicals which can initiate lipid peroxidation. CYP2E1 can also activate many over-the-counter medicines and solvents to toxic metabolites and deplete retinoids resulting in their depletion and deletrious effects. This is because, being a cytochrome P450 and using NADPH and oxygen, it has the ability to biotransform drugs when it has been induced by ethanol.", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-113748" ], "output_participant_list": [ "R-ALL-113745" ], "enzyme_list": [ "P05181-1", "P10635-1", "P20813-1", "P20853-1", "P33261-1", "P11509-1", "Q96SQ9-1", "P10632-1", "P11712-1", "P24903-1", "Q16696-1" ], "evidence": [ { "id": "R-HSA-143468", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-143468" } ] }, { "id": "R-HSA-211910", "name": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation", "equation": "", "summary": "Paclitaxel (Taxol) is a naturally occurring member of the taxane family of antitumor drugs. It acts by stabilizing microtubules. Paclitaxel is inactivated in human liver by CYP2C8, which catalyzes 6alpha-hydroxylation of paclitaxel.", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-211906" ], "output_participant_list": [ "R-ALL-211894" ], "enzyme_list": [ "P05181-1", "P10635-1", "P20813-1", "P20853-1", "P33261-1", "Q96SQ9-1", "P10632-1", "P11712-1", "P24903-1", "P33260-1", "Q16696-1" ], "evidence": [ { "id": "R-HSA-211910", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211910" } ] }, { "id": "R-HSA-211929", "name": "CYP2C19 5-hydroxylates omeprazole", "equation": "", "summary": "Omeprazole is a potent long-acting inhibitor of gastric acid secretion by irreversible binding to the proton pump (H+,K+) ATPase in the gastric parietal cell. CYP2C19 is the major P450 which involved in 5-hydroxylation of omeprazole.", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-211892" ], "output_participant_list": [ "R-ALL-211944" ], "enzyme_list": [ "P05181-1", "P10635-1", "P20813-1", "P20853-1", "P33261-1", "Q96SQ9-1", "P10632-1", "P11712-1", "P24903-1", "P33260-1", "Q16696-1" ], "evidence": [ { "id": "R-HSA-211929", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211929" } ] }, { "id": "R-HSA-211966", "name": "CYP2D6 4-hydroxylates debrisoquine", "equation": "", "summary": "CYP2D6 (debrisoquine 4-hydroxylase) has a wide substrate specificity and is an important cytochrme P450 in drug metabolism. It has extensive genetic polymorphism (called the debrisoquine/sparteine oxidation polymorphism) that influences its expression and function.The polymorphism is responsible for populations being poor metabolizers (PM) or extensive metabolizers (EM, normal). Approximately 10% of Caucasians and less than 1% of Asians lack the CYP2D6 protein because of two null alleles which do not encode the functional product. Further polymorphisms discovered recently have identified ultrarapid metabolizers (PM) (alleles with multiple gene copies) and intermediate metabolizers (IM) (deficiency in their metabolism capacity) (Zanger UM et al, 2004).", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-211993" ], "output_participant_list": [ "R-ALL-211952" ], "enzyme_list": [ "P05181-1", "P10635-1", "P33261-1", "P51589-1", "Q8TAV3-1", "P10632-1", "P11712-1" ], "evidence": [ { "id": "R-HSA-211966", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211966" } ] }, { "id": "R-HSA-211968", "name": "CYP2W1 oxidises INDOL", "equation": "", "summary": "CYP2W1 is a so-called \\ophan P450\\, a cytochrome P450 enzyme which has no defined function or endogenous/xenobiotic substrates. CYP2W1 has recently been shown to be selectively expressed in some forms of cancers and, with the low expression in normal tissues, could be rendered as a possible drug target during cancer therapy (Yoshioka et al. 2006). CYP2W1 can bioactivate several procarcinogens but at lower levels than other P450s. CYP2W1 also shows monooxygenase activity towards the pigment indole (INDOL), an ingredient of perfumes and coal tar.", "cellular_location": "smooth endoplasmic reticulum", "input_participant_list": [ "R-ALL-216547" ], "output_participant_list": [ "R-ALL-216598" ], "enzyme_list": [ "P10635-1", "Q8TAV3-1" ], "evidence": [ { "id": "R-HSA-211968", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211968" } ] }, { "id": "R-HSA-211983", "name": "CYP2J2 oxidises ARA", "equation": "", "summary": "Activation of phospholipases releases free arachidonic acid (ARA) from phospholipid bilayers which can then be metabolised to biologically active eicosanoids (signaling molecules which exert effects in inflammation and immunity). The cytochrome P450 enzyme CYP2J2 (arachidonic acid epoxygenase) is mainly expressed in human heart and can metabolise ARA to epoxyeicosatrienoic acid (EET). Four cis-EETs can be produced: 5,6-, 8,9-, 11,12- and 14,15-EET. Each of these can be formed as the R,S or the S,R enantiomer (Zeldin DC, 2001). The most abundant regioisomer in human heart is 14,15-EET although 11,12-EET possesses the most potent anti-inflammatory effect (Wu et al. 1996).", "cellular_location": "smooth endoplasmic reticulum", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P10635-1", "P20813-1", "P20853-1", "P51589-1", "P24903-1", "Q16696-1" ], "evidence": [ { "id": "R-HSA-211983", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211983" } ] }, { "id": "R-HSA-211988", "name": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation", "equation": "", "summary": "Tolbutamide is an oral hypoglycemic agent whose action is terminated by hydroxylation of the tolylsulfonyl methyl moiety. The reaction is catalyzed by CYP2C9.", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-9838902" ], "output_participant_list": [ "R-ALL-211937" ], "enzyme_list": [ "P05181-1", "P10635-1", "P20813-1", "P20853-1", "P33261-1", "Q96SQ9-1", "P10632-1", "P11712-1", "P24903-1", "P33260-1", "Q16696-1" ], "evidence": [ { "id": "R-HSA-211988", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211988" } ] }, { "id": "R-HSA-76354", "name": "Vinyl chloride is oxidized to 2-Chloroethylene oxide", "equation": "", "summary": "CYP2E1 can catalyze the oxidation of the vinyl halide vinyl chloride to the epoxide 2-chloroethylene oxide. The epoxide is very unstable and rearranges quickly to 2-chloroacetaldehyde. Both these products can interact with DNA and proteins.", "cellular_location": "smooth endoplasmic reticulum", "input_participant_list": [ "R-ALL-39417" ], "output_participant_list": [ "R-ALL-156524" ], "enzyme_list": [ "P05181-1", "P10635-1", "P20813-1", "P20853-1", "P33261-1", "P11509-1", "Q96SQ9-1", "P10632-1", "P11712-1", "P24903-1", "Q16696-1" ], "evidence": [ { "id": "R-HSA-76354", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76354" } ] }, { "id": "R-HSA-76397", "name": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)", "equation": "", "summary": "N-acetyl-p-benzoquinone imine (NAPQI) is the reactive intermediate of the analgesic and antipyretic, acetaminophen (INN, paracetamol). At usual doses, NAPQI is quickly detoxified by conjugation but in overdose situations, NAPQI is extremely toxic to liver tissue.", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-113555", "R-ALL-113564", "R-ALL-39427" ], "output_participant_list": [ "R-ALL-76396" ], "enzyme_list": [ "P05181-1", "P10635-1", "P20813-1", "P20853-1", "P33261-1", "P11509-1", "Q96SQ9-1", "P10632-1", "P11712-1", "P24903-1", "Q16696-1" ], "evidence": [ { "id": "R-HSA-76397", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76397" } ] }, { "id": "R-HSA-76416", "name": "Benzene is hydroxylated to phenol", "equation": "", "summary": "Benzene is an occupational and environmental toxicant and is implicated in myelogenous leukemia. For toxicity to occur, benzene is oxidised to phenol and subsequently to catechol and hydroquinone. CYP2E1 is the enzyme responsible for oxidation of benzene to phenol.", "cellular_location": "smooth endoplasmic reticulum", "input_participant_list": [ "R-ALL-31711" ], "output_participant_list": [ "R-ALL-29630" ], "enzyme_list": [ "P05181-1", "P10635-1", "P20813-1", "P20853-1", "P33261-1", "P11509-1", "Q96SQ9-1", "P10632-1", "P11712-1", "P24903-1", "Q16696-1" ], "evidence": [ { "id": "R-HSA-76416", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76416" } ] }, { "id": "R-HSA-76434", "name": "Dehalogenation of carbon tetrachloride to form a free radical", "equation": "", "summary": "Carbon tetrachloride (CCl4) has been widely used as a dry-cleaning agent, in fire extinguishers and in the manufacture of other halogenated hydrocarbons. At toxic doses, CCl4 exposure can damage the liver and kidneys. This toxicity results from CYP2E1-dependant reduction of CCl4 to the reactive trichloromethyl radical (CCl3.).", "cellular_location": "smooth endoplasmic reticulum", "input_participant_list": [ "R-ALL-40887" ], "output_participant_list": [ "R-ALL-29572", "R-ALL-76433" ], "enzyme_list": [ "P05181-1", "P10635-1", "P20813-1", "P20853-1", "P33261-1", "P11509-1", "Q96SQ9-1", "P10632-1", "P11712-1", "P24903-1", "Q16696-1" ], "evidence": [ { "id": "R-HSA-76434", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76434" } ] }, { "id": "R-HSA-76456", "name": "O-atom dealkylation of dextromethorphan", "equation": "", "summary": "At the beginning of this reaction, 1 molecule of 'H+', 1 molecule of 'Dextromethorphan', 1 molecule of 'Oxygen', and 1 molecule of 'NADPH' are present. At the end of this reaction, 1 molecule of 'NADP+', 1 molecule of 'Dextrorphan', 1 molecule of 'Formaldehyde', and 1 molecule of 'H2O' are present.

This reaction takes place in the 'smooth endoplasmic reticulum' and is mediated by the 'oxygen binding activity' of 'Cytochrome P450 2D6 '.
", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane, smooth endoplasmic reticulum", "input_participant_list": [ "R-ALL-39703" ], "output_participant_list": [ "R-ALL-76455" ], "enzyme_list": [ "P05181-1", "P10635-1", "P33261-1", "P51589-1", "Q8TAV3-1", "P10632-1", "P11712-1" ], "evidence": [ { "id": "R-HSA-76456", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76456" } ] }, { "id": "R-HSA-76475", "name": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide", "equation": "", "summary": "The volatile anesthetic halothane can undergo CYP2E1-catalyzed oxidation to form a reactive intermediate which can acetylate liver proteins. These proteins can then stimulate an immune reaction that mediates severe hepatic necrosis (\\halothane hepatitis\\).", "cellular_location": "smooth endoplasmic reticulum", "input_participant_list": [ "R-ALL-40795" ], "output_participant_list": [ "R-ALL-76473", "R-ALL-76474" ], "enzyme_list": [ "P05181-1", "P10635-1", "P20813-1", "P20853-1", "P33261-1", "P11509-1", "Q96SQ9-1", "P10632-1", "P11712-1", "P24903-1", "Q16696-1" ], "evidence": [ { "id": "R-HSA-76475", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76475" } ] }, { "id": "R-HSA-9027043", "name": "CYPs hydroxylate DHA to 14(R)-HDHA", "equation": "", "summary": "Using human leukocytes and platelets, Hong et al. found that incubating docosahexaenoic acid (DHA) with a mixture of human cytochrome P450 enzymes (CYP1A2, 2C8, 2C9, 2D6, 2E1 and 3A4) formed 14(R)-hydroxy-docsosahexaenoic acid (14(R)-HDHA), the precursor to maresin-like mediator 2 (MaR-L2) (Hong et al. 2014). There is no data to indicate which one or ones of these CYPs mediate this event under physiological conditions. CYP inhibition diminishes the formation of 14(R)-HDHA, confirming CYP determines 14(R)-hydroxylation (Hong et al. 2014). The CYP mixture also formed 22-hydroxy-docosahexaenoic acid (22-HDHA) by \u03c9-oxidation (not shown here). Although the CYP mixture also catalysed the formation of 14(S)-HDHA, the amount formed is minor compared to that formed by 12-lipoxygenase (Hong et al. 2014).", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-9024011" ], "output_participant_list": [], "enzyme_list": [ "P05181-1", "P10635-1", "P10632-1", "P11712-1", "P05177-1", "P08684-1" ], "evidence": [ { "id": "R-HSA-9027043", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9027043" } ] }, { "id": "R-HSA-9749986", "name": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA", "equation": "", "summary": "2,3-Dihydroxybenzoate (2,3-DHBA) is a minor oxidation product of salicylate (ST). The reaction is catalyzed by several CYP2 and CYP3 cytochromes in the ER of hepatocytes (Grootveld & Halliwell, 1988; Bojic et al, 2015)", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-9750011" ], "enzyme_list": [ "P05181-1", "P10635-1", "P33261-1", "P10632-1", "P11712-1", "P08684-1" ], "evidence": [ { "id": "R-HSA-9749986", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9749986" } ] }, { "id": "R-HSA-9750016", "name": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA", "equation": "", "summary": "2,5-Dihydroxybenzoate (gentisic acid, 2,5-DHBA) is a minor oxidation product of salicylate (ST). The reaction is catalyzed by several CYP2 and CYP3 cytochromes in the ER of hepatocytes (Grootveld & Halliwell, 1988; Bojic et al, 2015).", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-9750014" ], "enzyme_list": [ "P05181-1", "P10635-1", "P33261-1", "P10632-1", "P11712-1", "P08684-1" ], "evidence": [ { "id": "R-HSA-9750016", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9750016" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-113555", "participant_name": "H2 [endoplasmic reticulum lumen]", "crossref": [ { "id": "HMDB0001362", "database": "HMDB Metabolite", "url": "" }, { "id": "18276", "database": "ChEBI", "url": "" }, { "id": "C00282", "database": "COMPOUND", "url": "" }, { "id": "11533269", "database": "PubChem Substance", "url": "" }, { "id": "C00282", "database": "COMPOUND", "url": "" }, { "id": "18276", "database": "ChEBI", "url": 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"P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.55", "activity": "O2 + quinine + reduced [NADPH--hemoprotein reductase] = 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.56", "activity": "1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] = 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.73", "activity": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] } ] }, { "uniprot_ac": "P10632", "gene_name": "CYP2C8", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P10632", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10632" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P10632", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10632" } ] } ] }, { "uniprot_ac": "P10635", "gene_name": "CYP2D6", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P10635", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10635" } ] } ] }, { "uniprot_ac": "P11509", "gene_name": "CYP2A6", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P11509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11509" } ] } ] }, { "uniprot_ac": "P11712", "gene_name": "CYP2C9", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11712" } ] }, { "ec_number": "1.14.14.51", "activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11712" } ] }, { "ec_number": "1.14.14.52", "activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11712" } ] }, { "ec_number": "1.14.14.53", "activity": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11712" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P11712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11712" } ] } ] }, { "uniprot_ac": "P20813", "gene_name": "CYP2B6", "activity": [ { "ec_number": "1.14.13.-", "activity": "", "evidence": [ { "id": "P20813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20813" } ] } ] }, { "uniprot_ac": "P20815", "gene_name": "CYP3A5", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P20815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20815" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P20815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20815" } ] } ] }, { "uniprot_ac": "P20853", "gene_name": "CYP2A7", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P20853", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20853" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P20853", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20853" } ] } ] }, { "uniprot_ac": "P24470", "gene_name": "Cyp2c23", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P24470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24470" } ] } ] }, { "uniprot_ac": "P24903", "gene_name": "CYP2F1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P24903", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24903" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P24903", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24903" } ] } ] }, { "uniprot_ac": "P33260", "gene_name": "CYP2C18", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33260" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P33260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33260" } ] } ] }, { "uniprot_ac": "P33261", "gene_name": "CYP2C19", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] }, { "ec_number": "1.14.14.51", "activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] }, { "ec_number": "1.14.14.52", "activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] }, { "ec_number": "1.14.14.53", "activity": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] }, { "ec_number": "1.14.14.75", "activity": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] = 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] } ] }, { "uniprot_ac": "P51589", "gene_name": "CYP2J2", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P51589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51589" } ] }, { "ec_number": "5.4.4.7", "activity": "a hydroperoxyeicosatetraenoate = a hydroxy-epoxy-eicosatetraenoate.", "evidence": [ { "id": "P51589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51589" } ] }, { "ec_number": "1.14.14.73", "activity": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P51589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51589" } ] }, { "ec_number": "1.14.14.74", "activity": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P51589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51589" } ] } ] }, { "uniprot_ac": "P56657", "gene_name": "Cyp2c40", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P56657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56657" } ] } ] }, { "uniprot_ac": "Q16678", "gene_name": "CYP1B1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q16678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16678" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "Q16678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16678" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q16678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16678" } ] } ] }, { "uniprot_ac": "Q16696", "gene_name": "CYP2A13", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q16696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16696" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q16696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16696" } ] } ] }, { "uniprot_ac": "Q64429", "gene_name": "Cyp1b1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64429" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "Q64429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64429" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64429" } ] } ] }, { "uniprot_ac": "Q64678", "gene_name": "Cyp1b1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64678" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "Q64678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64678" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64678" } ] } ] }, { 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