{ "uniprot_canonical_ac": "P10243-1", "uniprot_ac": "P10243", "uniprot_id": "MYBA_HUMAN", "mass": { "chemical_mass": 85887.0, "monoisotopic_mass": 85887.0 }, "refseq": { "ac": "NP_001073885", "name": "myb-related protein A isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073885" }, "gene_names": [ { "name": "MYBL1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P10243", "id": "P10243" }, { "name": "A-MYB; AMYB", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073885", "id": "NP_001073885" }, { "name": "AMYB", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P10243", "id": "P10243" }, { "name": "MYBL1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073885", "id": "NP_001073885" } ], "protein_names": [ { "name": "Myb-related protein A", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P10243" }, { "name": "A-Myb", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10243" }, { "name": "Myb-like protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P10243" }, { "name": "myb-related protein A isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073885", "id": "NP_001073885" }, { "name": "myb-related protein A; v-myb avian myeloblastosis viral oncogene homolog-like 1; myb-like protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073885", "id": "NP_001073885" } ], "function": [ { "annotation": "A single-center study of the clinicopathologic correlates of gliomas with a MYB or MYBL1 alteration.", "evidence": [ { "database": "RefSeq", "id": "NP_001073885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073885" }, { "database": "PubMed", "id": "31595312", "url": "https://glygen.org/publication/PubMed/31595312" } ] }, { "annotation": "Integration analysis identifies MYBL1 as a novel immunotherapy biomarker affecting the immune microenvironment in clear cell renal cell carcinoma: Evidence based on machine learning and experiments. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001073885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073885" }, { "database": "PubMed", "id": "36591240", "url": "https://glygen.org/publication/PubMed/36591240" } ] }, { "annotation": "Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course.", "evidence": [ { "database": "RefSeq", "id": "NP_001073885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073885" }, { "database": "PubMed", "id": "31563982", "url": "https://glygen.org/publication/PubMed/31563982" } ] }, { "annotation": "MYBL1 induces transcriptional activation of ANGPT2 to promote tumor angiogenesis and confer sorafenib resistance in human hepatocellular carcinoma. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001073885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073885" }, { "database": "PubMed", "id": "35987690", "url": "https://glygen.org/publication/PubMed/35987690" } ] }, { "annotation": "Pediatric-type diffuse low-grade glioma with MYB/MYBL1 alteration: report of 2 cases.", "evidence": [ { "database": "RefSeq", "id": "NP_001073885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073885" }, { "database": "PubMed", "id": "36074655", "url": "https://glygen.org/publication/PubMed/36074655" } ] }, { "annotation": "Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3' (PubMed:8058310, PubMed:7987850). Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity). Transcriptional activator of SOX30 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P10243", "url": "https://www.uniprot.org/uniprot/P10243#function" }, { "database": "PubMed", "id": "7987850", "url": "https://glygen.org/publication/PubMed/7987850" }, { "database": "UniProtKB", "id": "P51960", "url": "https://www.uniprot.org/uniprot/P51960#function" }, { "database": "PubMed", "id": "8058310", "url": "https://glygen.org/publication/PubMed/8058310" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "P10243", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P10243" } ], "glycoeffect": [], "start_pos": 562, "end_pos": 562, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "A", "sequence_mut": "V", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "8", "chr_pos": "66572525", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "A562", "disease": [ { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "BT - 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"MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000185697", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000185697" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P10243", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P10243" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": 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"name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", 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"MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL 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"name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, 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"http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P10243", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P10243" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P10243", "url": "https://www.uniprot.org/uniprot/P10243" } ], "common_name": "Human" } ], "gene": [ { "name": "MYBL1", "url": "https://www.uniprot.org/uniprot/P10243", "locus": { "chromosome": "8", "start_pos": 66562175, "end_pos": 66614247, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000185697", "url": "https://www.ensembl.org/id/ENSG00000185697" } ] } } ], "crossref": [ { "id": "ENSG00000185697", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000185697", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "P10243", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P10243", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "cd00167", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00167", "database": "CDD", 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"database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015395", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015395", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017930", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017930", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:4603", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:4603", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "159405", "url": "http://www.omim.org/entry/159405", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_P10243", "url": "https://www.nextprot.org/entry/NX_P10243", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "P10243", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P10243", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "QMGGFPF", "url": "https://omabrowser.org/oma/group/QMGGFPF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "20023at2759", "url": "http://www.orthodb.org/?query=20023at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45614", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45614", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46621", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46621", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46621:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46621:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00249", "url": "http://pfam.xfam.org/family/PF00249", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07988", "url": "http://pfam.xfam.org/family/PF07988", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF09316", "url": "http://pfam.xfam.org/family/PF09316", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13921", "url": "http://pfam.xfam.org/family/PF13921", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P10243", "url": "https://pharos.nih.gov/targets/P10243", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_P10243", "url": "http://purl.obolibrary.org/obo/PR_P10243", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-5601884", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5601884", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001073885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073885", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E7EWZ1", "url": "https://www.uniprot.org/uniprot/E7EWZ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E7EWZ1-1", "url": "https://www.uniprot.org/uniprot/E7EWZ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P10243", "url": "https://www.uniprot.org/uniprot/P10243", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P10243-1", "url": "https://www.uniprot.org/uniprot/P10243-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P10243-2", "url": "https://www.uniprot.org/uniprot/P10243-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKRSRSEDEDDDLQYADHDYEVPQQKGLKKLWNRVKWTRDEDDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRWAEIAKLLPGRTDNSIKNHWNSTMRRKVEQEGYLQDGIKSERSSSKLQHKPCAAMDHMQTQNQFYIPVQIPGYQYVSPEGNCIEHVQPTSAFIQQPFIDEDPDKEKKIKELEMLLMSAENEVRRKRIPSQPGSFSSWSGSFLMDDNMSNTLNSLDEHTSEFYSMDENQPVSAQQNSPTKFLAVEANAVLSSLQTIPEFAETLELIESDPVAWSDVTSFDISDAAASPIKSTPVKLMRIQHNEGAMECQFNVSLVLEGKKNTCNGGNSEAVPLTSPNIAKFSTPPAILRKKRKMRVGHSPGSELRDGSLNDGGNMALKHTPLKTLPFSPSQFFNTCPGNEQLNIENPSFTSTPICGQKALITTPLHKETTPKDQKENVGFRTPTIRRSILGTTPRTPTPFKNALAAQEKKYGPLKIVSQPLAFLEEDIREVLKEETGTDLFLKEEDEPAYKSCKQENTASGKKVRKSLVLDNWEKEESGTQLLTEDISDMQSENRFTTSLLMIPLLEIHDNRCNLIPEKQDINSTNKTYTLTKKKPNPNTSKVVKLEKNLQSNCEWETVVYGKTEDQLIMTEQARRYLSTYTATSSTSRALIL", "length": 752, "header": "sp|P10243-1|MYBA_HUMAN Isoform 1 of Myb-related protein A OS=Homo sapiens OX=9606 GN=MYBL1 PE=1 SV=2 CANONICAL=P10243-1" }, "isoforms": [ { "isoform_ac": "E7EWZ1-1", "url": "", "sequence": { "sequence": "MAKRSRSEDEDDDLQYADHDYEVPQQKGLKKLWNRVKWTRDEDDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGKKRKMRVGHSPGSELRDGSLNDGGNMALKHTPLKTLPFSPSQFFNTCPGNEQLNIENPSFTSTPICGQKALITTPLHKETTPKDQKENVGFRTPTIRRSILGTTPRTPTPFKNALAAQEKKYGPLKIVSQPLAFLEEDIREVLKEETGTDLFLKEEDEPAYKSCKQENTASGKKVRKSLVLDNWEKEESGTQLLTEDISDMQSENRFTTSLLMIPLLEIHDNRCNLIPEKQDINSTNKTYTLTKKKPNPNTSKVVKLEKNLQSNCEWETVVYGKTEDQLIMTEQARRYLSTYTATSSTSRALIL", "length": 410, "header": "tr|E7EWZ1-1|MYBA_HUMAN Computationally mapped isoform of Myb-related protein A OS=Homo sapiens OX=9606 GN=MYBL1 PE=1 SV=1 CANONICAL=P10243-1" }, "locus": { "chromosome": "8", "start_pos": 66612838, "end_pos": 66564700, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000517885.5", "url": "https://www.ensembl.org/id/ENST00000517885.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000428265.1", "url": "https://www.ensembl.org/id/ENSP00000428265.1" } ] } }, { "isoform_ac": "P10243-1", "url": "", "sequence": { "sequence": "MAKRSRSEDEDDDLQYADHDYEVPQQKGLKKLWNRVKWTRDEDDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRWAEIAKLLPGRTDNSIKNHWNSTMRRKVEQEGYLQDGIKSERSSSKLQHKPCAAMDHMQTQNQFYIPVQIPGYQYVSPEGNCIEHVQPTSAFIQQPFIDEDPDKEKKIKELEMLLMSAENEVRRKRIPSQPGSFSSWSGSFLMDDNMSNTLNSLDEHTSEFYSMDENQPVSAQQNSPTKFLAVEANAVLSSLQTIPEFAETLELIESDPVAWSDVTSFDISDAAASPIKSTPVKLMRIQHNEGAMECQFNVSLVLEGKKNTCNGGNSEAVPLTSPNIAKFSTPPAILRKKRKMRVGHSPGSELRDGSLNDGGNMALKHTPLKTLPFSPSQFFNTCPGNEQLNIENPSFTSTPICGQKALITTPLHKETTPKDQKENVGFRTPTIRRSILGTTPRTPTPFKNALAAQEKKYGPLKIVSQPLAFLEEDIREVLKEETGTDLFLKEEDEPAYKSCKQENTASGKKVRKSLVLDNWEKEESGTQLLTEDISDMQSENRFTTSLLMIPLLEIHDNRCNLIPEKQDINSTNKTYTLTKKKPNPNTSKVVKLEKNLQSNCEWETVVYGKTEDQLIMTEQARRYLSTYTATSSTSRALIL", "length": 752, "header": "sp|P10243-1|MYBA_HUMAN Isoform 1 of Myb-related protein A OS=Homo sapiens OX=9606 GN=MYBL1 PE=1 SV=2 CANONICAL=P10243-1" }, "locus": { "chromosome": "8", "start_pos": 66612838, "end_pos": 66564700, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000522677.8", "url": "https://www.ensembl.org/id/ENST00000522677.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000429633.2", "url": "https://www.ensembl.org/id/ENSP00000429633.2" } ] } }, { "isoform_ac": "P10243-2", "url": "", "sequence": { "sequence": "MAKRSRSEDEDDDLQYADHDYEVPQQKGLKKLWNRVKWTRDEDDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRWAEIAKLLPGRTDNSIKNHWNSTMRRKVEQEGYLQDGIKSERSSSKLQHKPCAAMDHMQTQNQFYIPVQIPGYQYVSPEGNCIEHVQPTSAFIQQPFIDEDPDKEKKIKELEMLLMSAENEVRRKRIPSQPGSFSSWSGSFLMDDNMSNTLNSLDEHTSEFYSMDENQPVSAQQNSPTKFLAVEANAVLSSLQTIPEFAETLELIESDPVAWSDVTSFDISDAAASPIKSTPVKLMRIQHNEGAMECQFNVSLVLEGKKNTCNGGNSEAVPLTSPNIAKFSTPPAILRKKRKMRVGHSPGSELRDGSLNDGGNMALKHTPLKTLPFSPSQFFNTCPGNEQLNIENPSFTSTPICGQKALITTPLHKETTPKDQKENVGFRTPTIRRSILGTTPRTPTPFKNALAAQEKKYGPLKIVSQPLAFLEEDIREVLKEETGTDLFLKEEDEPAYKSCKQENTASGKKVRKSLVLDNWEKEESGTQLLTEDISDMQSNCEWETVVYGKTEDQLIMTEQARRYLSTYTATSSTSRALIL", "length": 692, "header": "sp|P10243-2|MYBA_HUMAN Isoform 2 of Myb-related protein A OS=Homo sapiens OX=9606 GN=MYBL1 PE=1 SV=2 CANONICAL=P10243-1" }, "locus": { "chromosome": "8", "start_pos": 66612838, "end_pos": 66564700, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000524176.2", "url": "https://www.ensembl.org/id/ENST00000524176.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000428011.2", "url": "https://www.ensembl.org/id/ENSP00000428011.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "P10243", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P10243" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" } ] } ], "phosphorylation": [ { "start_pos": 683, "end_pos": 683, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P10243", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10243" }, { "database": "PubMed", "id": "18491316", "url": "https://glygen.org/publication/PubMed/18491316" } ], "site_lbl": "Ser683" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.", "journal": "Mol. Cell", "date": "2007", "authors": "Litovchick L, Sadasivam S, Florens L, Zhu X, Swanson SK, Velmurugan S, Chen R, Washburn MP, Liu XS, DeCaprio JA", "evidence": [ { "database": "UniProtKB", "id": "P10243", "url": "https://www.uniprot.org/uniprot/P10243" } ], "reference": [ { "type": "PubMed", "id": "17531812", "url": "https://glygen.org/publication/PubMed/17531812" } ] }, { "title": "Phosphoproteome analysis of the human Chang liver cells using SCX and a complementary mass spectrometric strategy.", "journal": "Proteomics", "date": "2008", "authors": "Sui S, Wang J, Yang B, Song L, Zhang J, Chen M, Liu J, Lu Z, Cai Y, Chen S, Bi W, Zhu Y, He F, Qian X", "evidence": [ { "database": "iPTMnet", "id": "P10243-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10243-1" } ], "reference": [ { "type": "PubMed", "id": "18491316", "url": "https://glygen.org/publication/PubMed/18491316" } ] }, { "title": "A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice.", "journal": "Molecular cell", "date": "2008", "authors": "Aravin AA, Sachidanandam R, Bourc'his D, Schaefer C, Pezic D, Toth KF, Bestor T, Hannon GJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5601884", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5601884" } ], "reference": [ { "type": "PubMed", "id": "18922463", "url": "https://glygen.org/publication/PubMed/18922463" } ] }, { "title": "Lysine acetylation targets protein complexes and co-regulates major cellular functions.", "journal": "Science (New York, N.Y.)", "date": "2009", "authors": "Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M", "evidence": [ { "database": "UniProtKB", "id": "P10243", "url": "https://www.uniprot.org/uniprot/P10243" } ], "reference": [ { "type": "PubMed", "id": "19608861", "url": "https://glygen.org/publication/PubMed/19608861" } ] }, { "title": "Structural insights into piRNA recognition by the human PIWI-like 1 PAZ domain.", "journal": "Proteins", "date": "2011", "authors": "Zeng L, Zhang Q, Yan K, Zhou MM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5601884", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5601884" } ], "reference": [ { "type": "PubMed", "id": "21465557", "url": "https://glygen.org/publication/PubMed/21465557" } ] }, { "title": "proTRAC--a software for probabilistic piRNA cluster detection, visualization and analysis.", "journal": "BMC bioinformatics", "date": "2012", "authors": "Rosenkranz D, Zischler H", "evidence": [ { "database": "Reactome", "id": "R-HSA-5601884", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5601884" } ], "reference": [ { "type": "PubMed", "id": "22233380", "url": "https://glygen.org/publication/PubMed/22233380" } ] }, { "title": "Selective constraint on copy number variation in human piwi-interacting RNA Loci.", "journal": "PloS one", "date": "2012", "authors": "Gould DW, Lukic S, Chen KC", "evidence": [ { "database": "Reactome", "id": "R-HSA-5601884", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5601884" } ], "reference": [ { "type": "PubMed", "id": "23056369", "url": "https://glygen.org/publication/PubMed/23056369" } ] }, { "title": "MicroRNA and piRNA profiles in normal human testis detected by next generation sequencing.", "journal": "PloS one", "date": "2013", "authors": "Yang Q, Hua J, Wang L, Xu B, Zhang H, Ye N, Zhang Z, Yu D, Cooke HJ, Zhang Y, Shi Q", "evidence": [ { "database": "Reactome", "id": "R-HSA-5601884", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5601884" } ], "reference": [ { "type": "PubMed", "id": "23826142", "url": "https://glygen.org/publication/PubMed/23826142" } ] }, { "title": "PIWI-interacting RNAs (piRNAs) - a mouse testis perspective.", "journal": "Biochemistry. Biokhimiia", "date": "2013", "authors": "Bortvin A", "evidence": [ { "database": "Reactome", "id": "R-HSA-5601884", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5601884" } ], "reference": [ { "type": "PubMed", "id": "23980886", "url": "https://glygen.org/publication/PubMed/23980886" } ] }, { "title": "piClust: a density based piRNA clustering algorithm.", "journal": "Computational biology and chemistry", "date": "2014", "authors": "Jung I, Park JC, Kim S", "evidence": [ { "database": "Reactome", "id": "R-HSA-5601884", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5601884" } ], "reference": [ { "type": "PubMed", "id": "24656595", "url": "https://glygen.org/publication/PubMed/24656595" } ] }, { "title": "Uncovering global SUMOylation signaling networks in a site-specific manner.", "journal": "Nat. Struct. Mol. Biol.", "date": "2014", "authors": "Hendriks IA, D'Souza RC, Yang B, Verlaan-de Vries M, Mann M, Vertegaal AC", "evidence": [ { "database": "UniProtKB", "id": "P10243", "url": "https://www.uniprot.org/uniprot/P10243" } ], "reference": [ { "type": "PubMed", "id": "25218447", "url": "https://glygen.org/publication/PubMed/25218447" } ] }, { "title": "Synthesis of a Highly Azide-Reactive and Thermosensitive Biofunctional Reagent for Efficient Enrichment and Large-Scale Identification of O-GlcNAc Proteins by Mass Spectrometry.", "journal": "Analytical chemistry", "date": "2017", "authors": "Zhang W, Liu T, Dong H, Bai H, Tian F, Shi Z, Chen M, Wang J, Qin W, Qian X", "evidence": [ { "database": "O-GlcNAc Database", "id": "P10243", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P10243" } ], "reference": [ { "type": "PubMed", "id": "28510447", "url": "https://glygen.org/publication/PubMed/28510447" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "P10243", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P10243" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Isolation of human cDNA clones of myb-related genes, A-myb and B-myb.", "journal": "Nucleic Acids Res.", "date": "1988", "authors": "Nomura N, Takahashi M, Matsui M, Ishii S, Date T, Sasamoto S, Ishizaki R", "evidence": [ { "database": "UniProtKB", "id": "P10243", "url": "https://www.uniprot.org/uniprot/P10243" } ], "reference": [ { "type": "PubMed", "id": "3060855", "url": "https://glygen.org/publication/PubMed/3060855" } ] }, { "title": "Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course.", "journal": "Acta neuropathologica", "date": "2020", "authors": "Wefers AK, Stichel D, Schrimpf D, Coras R, Pages M, Tauziede-Espariat A, Varlet P, Schwarz D, Soylemezoglu F, Pohl U, Pimentel J, Meyer J, Hewer E, Japp A, Joshi A, Reuss DE, Reinhardt A, Sievers P, Casalini MB, Ebrahimi A, Huang K, Koelsche C, Low HL, Rebelo O, Marnoto D, Becker AJ, Staszewski O, Mittelbronn M, Hasselblatt M, Schittenhelm J, Cheesman E, de Oliveira RS, Queiroz RGP, Valera ET, Hans VH, Korshunov A, Olar A, Ligon KL, Pfister SM, Jaunmuktane Z, Brandner S, Tatevossian RG, Ellison DW, Jacques TS, Honavar M, Aronica E, Thom M, Sahm F, von Deimling A, Jones DTW, Blumcke I, Capper D", "evidence": [ { "database": "RefSeq", "id": "NP_001073885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073885" } ], "reference": [ { "type": "PubMed", "id": "31563982", "url": "https://glygen.org/publication/PubMed/31563982" } ] }, { "title": "A single-center study of the clinicopathologic correlates of gliomas with a MYB or MYBL1 alteration.", "journal": "Acta neuropathologica", "date": "2019", "authors": "Chiang J, Harreld JH, Tinkle CL, Moreira DC, Li X, Acharya S, Qaddoumi I, Ellison DW", "evidence": [ { "database": "RefSeq", "id": "NP_001073885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073885" } ], "reference": [ { "type": "PubMed", "id": "31595312", "url": "https://glygen.org/publication/PubMed/31595312" } ] }, { "title": "MYBL1 induces transcriptional activation of ANGPT2 to promote tumor angiogenesis and confer sorafenib resistance in human hepatocellular carcinoma.", "journal": "Cell death & disease", "date": "2022", "authors": "Zhu J, Wu Y, Yu Y, Li Y, Shen J, Zhang R", "evidence": [ { "database": "RefSeq", "id": "NP_001073885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073885" } ], "reference": [ { "type": "PubMed", "id": "35987690", "url": "https://glygen.org/publication/PubMed/35987690" } ] }, { "title": "Pediatric-type diffuse low-grade glioma with MYB/MYBL1 alteration: report of 2 cases.", "journal": "The neuroradiology journal", "date": "2022-09-08", "authors": "Kalelioglu Tuba, Rama Bharath, Cho Benjamin B, Lopes Beatriz M, Patel Sohil H", "evidence": [ { "database": "RefSeq", "id": "NP_001073885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073885" } ], "reference": [ { "type": "PubMed", "id": "36074655", "url": "https://glygen.org/publication/PubMed/36074655" } ] }, { "title": "Integration analysis identifies MYBL1 as a novel immunotherapy biomarker affecting the immune microenvironment in clear cell renal cell carcinoma: Evidence based on machine learning and experiments.", "journal": "Frontiers in immunology", "date": "2022", "authors": "Wang Tengda, Jian Wengang, Xue Wei, Meng Yuyang, Xia Zhinan, Li Qinchen, Xu Shenhao, Dong Yu, Mao Anli, Zhang Cheng", "evidence": [ { "database": 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