{ "uniprot_canonical_ac": "P0DJD4-1", "uniprot_ac": "P0DJD4", "uniprot_id": "RBY1C_HUMAN", "mass": { "chemical_mass": 55784.0, "monoisotopic_mass": 55784.0 }, "refseq": {}, "gene_names": [ { "name": "RBMY1C", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P0DJD4", "id": "P0DJD4" } ], "protein_names": [ { "name": "RNA-binding motif protein, Y chromosome, family 1 member C", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P0DJD4" } ], "function": [ { "annotation": "RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs.", "evidence": [ { "database": "UniProtKB", "id": "P0DJD4", "url": "https://www.uniprot.org/uniprot/P0DJD4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P0DJD4", "url": "https://www.uniprot.org/uniprot/P0DJD4" } ], "common_name": "Human" } ], "gene": [ { "name": "RBMY1C", "url": "https://www.uniprot.org/uniprot/P0DJD4", "locus": {} } ], "crossref": [ { "id": "cd12382", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12382", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "RBMY1C", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=RBMY1C", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "9914", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=9914", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012604", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012604", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "400006", "url": "http://www.omim.org/entry/400006", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_P0DJD4", "url": "https://www.nextprot.org/entry/NX_P0DJD4", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "PTHR48034", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48034", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48034:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48034:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "http://pfam.xfam.org/family/PF00076", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08081", "url": "http://pfam.xfam.org/family/PF08081", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P0DJD4", "url": "https://pharos.nih.gov/targets/P0DJD4", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_P0DJD4", "url": "http://purl.obolibrary.org/obo/PR_P0DJD4", "database": "PRO", "categories": [ "Protein" ] }, { "id": "P0DJD4", "url": "https://www.uniprot.org/uniprot/P0DJD4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P0DJD4-1", "url": "https://www.uniprot.org/uniprot/P0DJD4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDRTSKSRGFAFITFENPADAKNAAKDMNGKSLHGKAIKVEQAQKPSFQSGGRRRPPASSRNRSPSGSLRSARGSRGGTRGWLPSHEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARSNSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATNDGNHPSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGHAYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPSSRETRDYAPPHRDYAYRDYGHSSWDEHSSRGYSYHDGYGEALGRDHSEHLSGSSYRDALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRDRYGRSWESYSSCGDFHYCDREHVCRKDQRNPPSLGRVLPDPREACGSSSYVASIVDGGESRSEKGDSSRY", "length": 496, "header": "sp|P0DJD4-1|RBY1C_HUMAN Isoform 1 of RNA-binding motif protein, Y chromosome, family 1 member C OS=Homo sapiens OX=9606 GN=RBMY1C PE=1 SV=1 CANONICAL=P0DJD4-1" }, "isoforms": [ { "isoform_ac": "P0DJD4-1", "url": "", "sequence": { "sequence": "MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDRTSKSRGFAFITFENPADAKNAAKDMNGKSLHGKAIKVEQAQKPSFQSGGRRRPPASSRNRSPSGSLRSARGSRGGTRGWLPSHEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARSNSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATNDGNHPSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGHAYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPSSRETRDYAPPHRDYAYRDYGHSSWDEHSSRGYSYHDGYGEALGRDHSEHLSGSSYRDALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRDRYGRSWESYSSCGDFHYCDREHVCRKDQRNPPSLGRVLPDPREACGSSSYVASIVDGGESRSEKGDSSRY", "length": 496, "header": "sp|P0DJD4-1|RBY1C_HUMAN Isoform 1 of RNA-binding motif protein, Y chromosome, family 1 member C OS=Homo sapiens OX=9606 GN=RBMY1C PE=1 SV=1 CANONICAL=P0DJD4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis.", "journal": "Hum. Mol. Genet.", "date": "1999", "authors": "Venables JP, Vernet C, Chew SL, Elliott DJ, Cowmeadow RB, Wu J, Cooke HJ, Artzt K, Eperon IC", "evidence": [ { "database": "UniProtKB", "id": "P0DJD4", "url": "https://www.uniprot.org/uniprot/P0DJD4" } ], "reference": [ { "type": "PubMed", "id": "10332027", "url": "https://glygen.org/publication/PubMed/10332027" } ] }, { "title": "RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing.", "journal": "Hum. Mol. Genet.", "date": "2000", "authors": "Venables JP, Elliott DJ, Makarova OV, Makarov EM, Cooke HJ, Eperon IC", "evidence": [ { "database": "UniProtKB", "id": "P0DJD4", "url": "https://www.uniprot.org/uniprot/P0DJD4" } ], "reference": [ { "type": "PubMed", "id": "10749975", "url": "https://glygen.org/publication/PubMed/10749975" } ] }, { "title": "The role of potential splicing factors including RBMY, RBMX, hnRNPG-T and STAR proteins in spermatogenesis.", "journal": "Int. J. Androl.", "date": "2004", "authors": "Elliott David J", "evidence": [ { "database": "UniProtKB", "id": "P0DJD4", "url": "https://www.uniprot.org/uniprot/P0DJD4" } ], "reference": [ { "type": "PubMed", "id": "15595951", "url": "https://glygen.org/publication/PubMed/15595951" } ] }, { "title": "Expression of RBM in the nuclei of human germ cells is dependent on a critical region of the Y chromosome long arm.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1997", "authors": "Elliott DJ, Millar MR, Oghene K, Ross A, Kiesewetter F, Pryor J, McIntyre M, Hargreave TB, Saunders PT, Vogt PH, Chandley AC, Cooke H", "evidence": [ { "database": "UniProtKB", "id": "P0DJD4", "url": "https://www.uniprot.org/uniprot/P0DJD4" } ], "reference": [ { "type": "PubMed", "id": "9108067", "url": "https://glygen.org/publication/PubMed/9108067" } ] }, { "title": "Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene.", "journal": "Genomics", "date": "1998", "authors": "Chai N N, Zhou H, Hernandez J, Najmabadi H, Bhasin S, Yen P H", "evidence": [ { "database": "UniProtKB", "id": "P0DJD4", "url": "https://www.uniprot.org/uniprot/P0DJD4" } ], "reference": [ { "type": "PubMed", "id": "9598316", "url": "https://glygen.org/publication/PubMed/9598316" } ] } ], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of mRNA splicing, via spliceosome", "id": "GO:0048026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048026", "evidence": [ { "database": "UniProtKB", "id": "P0DJD4", "url": "https://www.uniprot.org/uniprot/P0DJD4" } ], "pmid": "" }, { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "P0DJD4", "url": "https://www.uniprot.org/uniprot/P0DJD4" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "P0DJD4", "url": "https://www.uniprot.org/uniprot/P0DJD4" } ], "pmid": "" }, { "name": "regulation of RNA splicing", "id": "GO:0043484", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043484", "evidence": [ { "database": "UniProtKB", "id": "P0DJD4", "url": "https://www.uniprot.org/uniprot/P0DJD4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "P0DJD4", "url": "https://www.uniprot.org/uniprot/P0DJD4" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "P0DJD4", "url": "https://www.uniprot.org/uniprot/P0DJD4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "P0DJD4", "url": "https://www.uniprot.org/uniprot/P0DJD4" } ], "pmid": "" }, { "name": "spliceosomal complex", "id": "GO:0005681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005681", "evidence": [ { "database": "UniProtKB", "id": "P0DJD4", "url": "https://www.uniprot.org/uniprot/P0DJD4" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "P0DJD4", "url": "https://www.uniprot.org/uniprot/P0DJD4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 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