{ "uniprot_canonical_ac": "P09341-1", "uniprot_ac": "P09341", "uniprot_id": "GROA_HUMAN", "mass": { "chemical_mass": 11301.0, "monoisotopic_mass": 11301.0 }, "refseq": { "ac": "NP_001502", "name": "growth-regulated alpha protein precursor", "summary": "This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001502" }, "gene_names": [ { "name": "CXCL1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P09341", "id": "P09341" }, { "name": "CXCL1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001502", "id": "NP_001502" }, { "name": "FSP; GRO1; GROa; MGSA; MGSA-a; NAP-3; SCYB1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001502", "id": "NP_001502" }, { "name": "GRO1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P09341", "id": "P09341" }, { "name": "GROA", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P09341", "id": "P09341" }, { "name": "GRO", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P09341", "id": "P09341" }, { "name": "MGSA", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P09341", "id": "P09341" }, { "name": "SCYB1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P09341", "id": "P09341" } ], "protein_names": [ { "name": "Growth-regulated alpha protein", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P09341" }, { "name": "C-X-C motif chemokine 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P09341" }, { "name": "GRO-alpha(1-73)", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P09341" }, { "name": "GRO1 oncogene (melanoma growth-stimulating activity); fibroblast secretory protein; GRO1 oncogene (melanoma growth stimulating activity, alpha); chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); growth-regulated alpha protein; MGSA alpha; melanoma growth stimulatory activity alpha; GRO-alpha(1-73); C-X-C motif chemokine 1; neutrophil-activating protein 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001502", "id": "NP_001502" }, { "name": "MGSA", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P09341" }, { "name": "Melanoma growth stimulatory activity", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P09341" }, { "name": "NAP-3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P09341" }, { "name": "Neutrophil-activating protein 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P09341" }, { "name": "growth-regulated alpha protein precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001502", "id": "NP_001502" } ], "function": [ { "annotation": "CXCL1 promotes immune escape in colorectal cancer by autophagy-mediated MHC-I degradation.", "evidence": [ { "database": "RefSeq", "id": "NP_001502", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001502" }, { "database": "PubMed", "id": "37802708", "url": "https://glygen.org/publication/PubMed/37802708" } ] }, { "annotation": "Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.", "evidence": [ { "database": "UniProtKB", "id": "P09341", "url": "https://www.uniprot.org/uniprot/P09341#function" }, { "database": "PubMed", "id": "10095777", "url": "https://glygen.org/publication/PubMed/10095777" } ] }, { "annotation": "TGFbeta1 induces CXCL1 to promote stemness features in lung cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_001502", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001502" }, { "database": "PubMed", "id": "38158808", "url": "https://glygen.org/publication/PubMed/38158808" } ] }, { "annotation": "This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014].", "evidence": [ { "database": "RefSeq", "id": "NP_001502", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001502" } ] }, { "annotation": "This protein displays antimicrobial activity against E. coli and S. aureus.", "evidence": [ { "database": "RefSeq", "id": "NP_001502", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001502" }, { "database": "PubMed", "id": "12949249", "url": "https://glygen.org/publication/PubMed/12949249" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "P09341", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P09341" } ], "glycoeffect": [], "start_pos": 73, "end_pos": 73, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "E", "sequence_mut": "K", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "4", "chr_pos": "73869785", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "E73", "disease": [ 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"url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": 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{ "database": "Bgee", "id": "ENSG00000163739", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000163739" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "63.08", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000163739", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000163739" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "89.1", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000163739", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000163739" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "75.01", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000163739", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000163739" } 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"evidence": [ { "database": "BioXpress", "id": "P09341", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P09341" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P09341", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P09341" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P09341" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "P09341", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P09341" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": 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