{ "uniprot_canonical_ac": "P08799-1", "uniprot_ac": "P08799", "uniprot_id": "MYS2_DICDI", "mass": { "chemical_mass": 243786.0, "monoisotopic_mass": 243786.0 }, "refseq": { "ac": "XP_637740", "name": "myosin II heavy chain", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_637740" }, "gene_names": [ { "name": "mhcA", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P08799", "id": "P08799" }, { "name": "DDB_G0286355", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P08799", "id": "P08799" }, { "name": "mhcA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_637740", "id": "XP_637740" } ], "protein_names": [ { "name": "Myosin-2 heavy chain", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P08799" }, { "name": "Myosin II heavy chain", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P08799" }, { "name": "myosin II heavy chain", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_637740", "id": "XP_637740" }, { "name": "myosin heavy chain", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_637740", "id": "XP_637740" } ], "function": [ { "annotation": "Myosin is a protein that binds to actin and has ATPase activity that is activated by actin.", "evidence": [ { "database": "UniProtKB", "id": "P08799", "url": "https://www.uniprot.org/uniprot/P08799#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "P08799", "url": "https://www.uniprot.org/uniprot/P08799" } ], "common_name": "Cellular slime molds" } ], "gene": [ { "name": "mhcA", "url": "https://www.uniprot.org/uniprot/P08799", "locus": {} } ], "crossref": [ { "id": "5.6.1.8", "url": 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"categories": [ "3D Structure" ] }, { "id": "3MNQ", "url": "https://www.rcsb.org/structure/3MNQ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3MYH", "url": "https://www.rcsb.org/structure/3MYH", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3MYK", "url": "https://www.rcsb.org/structure/3MYK", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3MYL", "url": "https://www.rcsb.org/structure/3MYL", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4AE3", "url": "https://www.rcsb.org/structure/4AE3", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4PJK", "url": "https://www.rcsb.org/structure/4PJK", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6Z2S", "url": "https://www.rcsb.org/structure/6Z2S", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6Z7T", "url": "https://www.rcsb.org/structure/6Z7T", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6Z7U", "url": "https://www.rcsb.org/structure/6Z7U", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7B1A", "url": "https://www.rcsb.org/structure/7B1A", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00063", "url": "http://pfam.xfam.org/family/PF00063", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01576", "url": "http://pfam.xfam.org/family/PF01576", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02736", "url": "http://pfam.xfam.org/family/PF02736", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_P08799", "url": "http://purl.obolibrary.org/obo/PR_P08799", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DDI-5627123", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-5627123", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_637740", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_637740", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P08799", "url": "https://www.uniprot.org/uniprot/P08799", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P08799-1", "url": "https://www.uniprot.org/uniprot/P08799-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNPIHDRTSDYHKYLKVKQGDSDLFKLTVSDKRYIWYNPDPKERDSYECGEIVSETSDSFTFKTVDGQDRQVKKDDANQRNPIKFDGVEDMSELSYLNEPAVFHNLRVRYNQDLIYTYSGLFLVAVNPFKRIPIYTQEMVDIFKGRRRNEVAPHIFAISDVAYRSMLDDRQNQSLLITGESGAGKTENTKKVIQYLASVAGRNQANGSGVLEQQILQANPILEAFGNAKTTRNNNSSRFGKFIEIQFNSAGFISGASIQSYLLEKSRVVFQSETERNYHIFYQLLAGATAEEKKALHLAGPESFNYLNQSGCVDIKGVSDSEEFKITRQAMDIVGFSQEEQMSIFKIIAGILHLGNIKFEKGAGEGAVLKDKTALNAASTVFGVNPSVLEKALMEPRILAGRDLVAQHLNVEKSSSSRDALVKALYGRLFLWLVKKINNVLCQERKAYFIGVLDISGFEIFKVNSFEQLCINYTNEKLQQFFNHHMFKLEQEEYLKEKINWTFIDFGLDSQATIDLIDGRQPPGILALLDEQSVFPNATDNTLITKLHSHFSKKNAKYEEPRFSKTEFGVTHYAGQVMYEIQDWLEKNKDPLQQDLELCFKDSSDNVVTKLFNDPNIASRAKKGANFITVAAQYKEQLASLMATLETTNPHFVRCIIPNNKQLPAKLEDKVVLDQLRCNGVLEGIRITRKGFPNRIIYADFVKRYYLLAPNVPRDAEDSQKATDAVLKHLNIDPEQYRFGITKIFFRAGQLARIEEAREQRISEIIKAIQAATRGWIARKVYKQAREHTVAARIIQQNLRAYIDFKSWPWWKLFSKARPLLKRRNFEKEIKEKEREILELKSNLTDSTTQKDKLEKSLKDTESNVLDLQRQLKAEKETLKAMYDSKDALEAQKRELEIRVEDMESELDEKKLALENLQNQKRSVEEKVRDLEEELQEEQKLRNTLEKLKKKYEEELEEMKRVNDGQSDTISRLEKIKDELQKEVEELTESFSEESKDKGVLEKTRVRLQSELDDLTVRLDSETKDKSELLRQKKKLEEELKQVQEALAAETAAKLAQEAANKKLQGEYTELNEKFNSEVTARSNVEKSKKTLESQLVAVNNELDEEKKNRDALEKKKKALDAMLEEMKDQLESTGGEKKSLYDLKVKQESDMEALRNQISELQSTIAKLEKIKSTLEGEVARLQGELEAEQLAKSNVEKQKKKVELDLEDKSAQLAEETAAKQALDKLKKKLEQELSEVQTQLSEANNKNVNSDSTNKHLETSFNNLKLELEAEQKAKQALEKKRLGLESELKHVNEQLEEEKKQKESNEKRKVDLEKEVSELKDQIEEEVASKKAVTEAKNKKESELDEIKRQYADVVSSRDKSVEQLKTLQAKNEELRNTAEEAEGQLDRAERSKKKAEFDLEEAVKNLEEETAKKVKAEKAMKKAETDYRSTKSELDDAKNVSSEQYVQIKRLNEELSELRSVLEEADERCNSAIKAKKTAESALESLKDEIDAANNAKAKAERKSKELEVRVAELEESLEDKSGTVNVEFIRKKDAEIDDLRARLDRETESRIKSDEDKKNTRKQFADLEAKVEEAQREVVTIDRLKKKLESDIIDLSTQLDTETKSRIKIEKSKKKLEQTLAERRAAEEGSSKAADEEIRKQVWQEVDELRAQLDSERAALNASEKKIKSLVAEVDEVKEQLEDEILAKDKLVKAKRALEVELEEVRDQLEEEEDSRSELEDSKRRLTTEVEDIKKKYDAEVEQNTKLDEAKKKLTDDVDTLKKQLEDEKKKLNESERAKKRLESENEDFLAKLDAEVKNRSRAEKDRKKYEKDLKDTKYKLNDEAATKTQTEIGAAKLEDQIDELRSKLEQEQAKATQADKSKKTLEGEIDNLRAQIEDEGKIKMRLEKEKRALEGELEELRETVEEAEDSKSEAEQSKRLVELELEDARRNLQKEIDAKEIAEDAKSNLQREIVEAKGRLEEESIARTNSDRSRKRLEAEIDALTAQVDAEQKAKNQQIKENKKIETELKEYRKKFGESEKTKTKEFLVVEKLETDYKRAKKEAADEQQQRLTVENDLRKHLSEISLLKDAIDKLQRDHDKTKRELETETASKIEMQRKMADFFGGFKA", "length": 2116, "header": "sp|P08799-1|MYS2_DICDI Isoform 1 of Myosin-2 heavy chain OS=Dictyostelium discoideum OX=44689 GN=mhcA PE=1 SV=3 CANONICAL=P08799-1" }, "isoforms": [ { "isoform_ac": "P08799-1", "url": "", "sequence": { "sequence": "MNPIHDRTSDYHKYLKVKQGDSDLFKLTVSDKRYIWYNPDPKERDSYECGEIVSETSDSFTFKTVDGQDRQVKKDDANQRNPIKFDGVEDMSELSYLNEPAVFHNLRVRYNQDLIYTYSGLFLVAVNPFKRIPIYTQEMVDIFKGRRRNEVAPHIFAISDVAYRSMLDDRQNQSLLITGESGAGKTENTKKVIQYLASVAGRNQANGSGVLEQQILQANPILEAFGNAKTTRNNNSSRFGKFIEIQFNSAGFISGASIQSYLLEKSRVVFQSETERNYHIFYQLLAGATAEEKKALHLAGPESFNYLNQSGCVDIKGVSDSEEFKITRQAMDIVGFSQEEQMSIFKIIAGILHLGNIKFEKGAGEGAVLKDKTALNAASTVFGVNPSVLEKALMEPRILAGRDLVAQHLNVEKSSSSRDALVKALYGRLFLWLVKKINNVLCQERKAYFIGVLDISGFEIFKVNSFEQLCINYTNEKLQQFFNHHMFKLEQEEYLKEKINWTFIDFGLDSQATIDLIDGRQPPGILALLDEQSVFPNATDNTLITKLHSHFSKKNAKYEEPRFSKTEFGVTHYAGQVMYEIQDWLEKNKDPLQQDLELCFKDSSDNVVTKLFNDPNIASRAKKGANFITVAAQYKEQLASLMATLETTNPHFVRCIIPNNKQLPAKLEDKVVLDQLRCNGVLEGIRITRKGFPNRIIYADFVKRYYLLAPNVPRDAEDSQKATDAVLKHLNIDPEQYRFGITKIFFRAGQLARIEEAREQRISEIIKAIQAATRGWIARKVYKQAREHTVAARIIQQNLRAYIDFKSWPWWKLFSKARPLLKRRNFEKEIKEKEREILELKSNLTDSTTQKDKLEKSLKDTESNVLDLQRQLKAEKETLKAMYDSKDALEAQKRELEIRVEDMESELDEKKLALENLQNQKRSVEEKVRDLEEELQEEQKLRNTLEKLKKKYEEELEEMKRVNDGQSDTISRLEKIKDELQKEVEELTESFSEESKDKGVLEKTRVRLQSELDDLTVRLDSETKDKSELLRQKKKLEEELKQVQEALAAETAAKLAQEAANKKLQGEYTELNEKFNSEVTARSNVEKSKKTLESQLVAVNNELDEEKKNRDALEKKKKALDAMLEEMKDQLESTGGEKKSLYDLKVKQESDMEALRNQISELQSTIAKLEKIKSTLEGEVARLQGELEAEQLAKSNVEKQKKKVELDLEDKSAQLAEETAAKQALDKLKKKLEQELSEVQTQLSEANNKNVNSDSTNKHLETSFNNLKLELEAEQKAKQALEKKRLGLESELKHVNEQLEEEKKQKESNEKRKVDLEKEVSELKDQIEEEVASKKAVTEAKNKKESELDEIKRQYADVVSSRDKSVEQLKTLQAKNEELRNTAEEAEGQLDRAERSKKKAEFDLEEAVKNLEEETAKKVKAEKAMKKAETDYRSTKSELDDAKNVSSEQYVQIKRLNEELSELRSVLEEADERCNSAIKAKKTAESALESLKDEIDAANNAKAKAERKSKELEVRVAELEESLEDKSGTVNVEFIRKKDAEIDDLRARLDRETESRIKSDEDKKNTRKQFADLEAKVEEAQREVVTIDRLKKKLESDIIDLSTQLDTETKSRIKIEKSKKKLEQTLAERRAAEEGSSKAADEEIRKQVWQEVDELRAQLDSERAALNASEKKIKSLVAEVDEVKEQLEDEILAKDKLVKAKRALEVELEEVRDQLEEEEDSRSELEDSKRRLTTEVEDIKKKYDAEVEQNTKLDEAKKKLTDDVDTLKKQLEDEKKKLNESERAKKRLESENEDFLAKLDAEVKNRSRAEKDRKKYEKDLKDTKYKLNDEAATKTQTEIGAAKLEDQIDELRSKLEQEQAKATQADKSKKTLEGEIDNLRAQIEDEGKIKMRLEKEKRALEGELEELRETVEEAEDSKSEAEQSKRLVELELEDARRNLQKEIDAKEIAEDAKSNLQREIVEAKGRLEEESIARTNSDRSRKRLEAEIDALTAQVDAEQKAKNQQIKENKKIETELKEYRKKFGESEKTKTKEFLVVEKLETDYKRAKKEAADEQQQRLTVENDLRKHLSEISLLKDAIDKLQRDHDKTKRELETETASKIEMQRKMADFFGGFKA", "length": 2116, "header": "sp|P08799-1|MYS2_DICDI Isoform 1 of Myosin-2 heavy chain OS=Dictyostelium discoideum OX=44689 GN=mhcA PE=1 SV=3 CANONICAL=P08799-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 1823, "end_pos": 1823, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine; by MHCK", "evidence": [ { "database": "UniProtKB", "id": "P08799", "url": "https://www.uniprot.org/uniprot/P08799" } ], "site_lbl": "Thr1823" }, { "start_pos": 1833, "end_pos": 1833, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine; by MHCK", "evidence": [ { "database": "UniProtKB", "id": "P08799", "url": "https://www.uniprot.org/uniprot/P08799" } ], "site_lbl": "Thr1833" }, { "start_pos": 2029, "end_pos": 2029, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine; by MHCK", "evidence": [ { "database": "UniProtKB", "id": "P08799", "url": "https://www.uniprot.org/uniprot/P08799" } ], "site_lbl": "Thr2029" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Structure of a genetically engineered molecular motor.", "journal": "EMBO J.", "date": "2001", "authors": "Kliche W, Fujita-Becker S, Kollmar M, Manstein D J, Kull F J", "evidence": [ { "database": "UniProtKB", "id": "P08799", "url": "https://www.uniprot.org/uniprot/P08799" } ], "reference": [ { "type": "PubMed", "id": "11226153", "url": "https://glygen.org/publication/PubMed/11226153" } ] }, { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Eichinger L, Pachebat J A, Gl\u00f6ckner G, Rajandream M-A, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov B A, Rivero F, Bankier A T, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, Hauser H, James K, Quiles M, Madan Babu M, Saito T, Buchrieser C, Wardroper A, Felder M, Thangavelu M, Johnson D, Knights A, Loulseged H, Mungall K, Oliver K, Price C, Quail M A, Urushihara H, Hernandez J, Rabbinowitsch E, Steffen D, Sanders M, Ma J, Kohara Y, Sharp S, Simmonds M, Spiegler S, Tivey A, Sugano S, White B, Walker D, Woodward J, Winckler T, Tanaka Y, Shaulsky G, Schleicher M, Weinstock G, Rosenthal A, Cox E C, Chisholm R L, Gibbs R, Loomis W F, Platzer M, Kay R R, Williams J, Dear P H, Noegel A A, Barrell B, Kuspa A", "evidence": [ { "database": "UniProtKB", "id": "P08799", "url": "https://www.uniprot.org/uniprot/P08799" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] }, { "title": "Thirteen is 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