{ "uniprot_canonical_ac": "P07550-1", "uniprot_ac": "P07550", "uniprot_id": "ADRB2_HUMAN", "mass": { "chemical_mass": 46459.0, "monoisotopic_mass": 46459.0 }, "refseq": { "ac": "NP_000015", "name": "beta-2 adrenergic receptor", "summary": "This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This receptor is also a transcription regulator of the alpha-synuclein gene, and together, both genes are believed to be associated with risk of Parkinson's Disease. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity, type 2 diabetes and cardiovascular disease. [provided by RefSeq, Oct 2019].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000015" }, "gene_names": [ { "name": "ADRB2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P07550", "id": "P07550" }, { "name": "ADRB2R; ADRBR; ARB2; B2AR; BAR; BETA2AR", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000015", "id": "NP_000015" }, { "name": "ADRB2R", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P07550", "id": "P07550" }, { "name": "ADRB2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000015", "id": "NP_000015" }, { "name": "B2AR", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P07550", "id": "P07550" } ], "protein_names": [ { "name": "Beta-2 adrenergic receptor", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P07550" }, { "name": "Beta-2 adrenoceptor", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07550" }, { "name": "Beta-2 adrenoreceptor", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P07550" }, { "name": "beta-2 adrenergic receptor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000015", "id": "NP_000015" }, { "name": "catecholamine receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor; adrenergic, beta-2-, receptor, surface; adrenoceptor beta 2 surface", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000015", "id": "NP_000015" } ], "function": [ { "annotation": "Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550#function" }, { "database": "PubMed", "id": "7915137", "url": "https://glygen.org/publication/PubMed/7915137" }, { "database": "PubMed", "id": "2831218", "url": "https://glygen.org/publication/PubMed/2831218" } ] }, { "annotation": "Biased Signaling in Mutated Variants of beta2-Adrenergic Receptor: Insights from Molecular Dynamics Simulations.", "evidence": [ { "database": "RefSeq", "id": "NP_000015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000015" }, { "database": "PubMed", "id": "38194225", "url": "https://glygen.org/publication/PubMed/38194225" } ] }, { "annotation": "Evaluation of ADRB2 and OATP2A1 genetic polymorphisms in Indian patients with primary open-angle glaucoma.", "evidence": [ { "database": "RefSeq", "id": "NP_000015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000015" }, { "database": "PubMed", "id": "37906648", "url": "https://glygen.org/publication/PubMed/37906648" } ] }, { "annotation": "Evaluation value and mechanism of ADRB2 and FCER1B gene polymorphisms in preterm infants with congenital respiratory diseases. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000015" }, { "database": "PubMed", "id": "38158688", "url": "https://glygen.org/publication/PubMed/38158688" } ] }, { "annotation": "The association of gene polymorphisms in catechol-O'methyltransferase (COMT) and beta2-adrenergic receptor (ADRB2) with temporomandibular joint disorders.", "evidence": [ { "database": "RefSeq", "id": "NP_000015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000015" }, { "database": "PubMed", "id": "38043362", "url": "https://glygen.org/publication/PubMed/38043362" } ] }, { "annotation": "This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This receptor is also a transcription regulator of the alpha-synuclein gene, and together, both genes are believed to be associated with risk of Parkinson's Disease. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity, type 2 diabetes and cardiovascular disease. [provided by RefSeq, Oct 2019].", "evidence": [ { "database": "RefSeq", "id": "NP_000015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000015" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs144618094", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs144618094" }, { "id": "rs144618094", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs144618094" }, { "id": "rs144618094", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs144618094#frequency_tab" }, { "id": "rs144618094", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs144618094" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 15, "end_pos": 15, "sequence_org": "N", "sequence_mut": "D", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NGS->DGS).", "chr_id": "5", "chr_pos": "148826874", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N15", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs33973603", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs33973603" }, { "id": "rs33973603", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs33973603" }, { "id": "rs33973603", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs33973603" }, { "id": "rs33973603", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs33973603#frequency_tab" }, { "id": "rs33973603", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs33973603" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 15, "end_pos": 15, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NGS->SGS).", "chr_id": "5", "chr_pos": "148826875", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "0.000599", "site_lbl": "N15", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs200042760", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs200042760" }, { "id": "rs200042760", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs200042760" }, { "id": "rs200042760", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs200042760" }, { "id": "rs200042760", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs200042760#frequency_tab" }, { "id": "rs200042760", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs200042760" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 187, "end_pos": 187, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NET->SET).", "chr_id": "5", "chr_pos": "148827391", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "0.000998", "site_lbl": "N187", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1580822963", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1580822963" }, { "id": "rs1580822963", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1580822963" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 189, "end_pos": 189, "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NET->NEN).", "chr_id": "5", "chr_pos": "148827397", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T189", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1580822956", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1580822956" }, { "id": "rs1580822956", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1580822956" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 189, "end_pos": 189, "sequence_org": "T", "sequence_mut": "P", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NET->NEP).", "chr_id": "5", "chr_pos": "148827396", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T189", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1287505878", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1287505878" }, { "id": "rs1287505878", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1287505878" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 201, "end_pos": 201, "sequence_org": "I", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (IAS->NAS).", "chr_id": "5", "chr_pos": "148827433", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I201", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "P07550", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P07550" } ], "glycoeffect": [], "start_pos": 343, "end_pos": 343, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "C", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "5", "chr_pos": "148827858", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "R343", "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. 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}, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL 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"name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, 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"http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "P07550", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07550" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "P07550", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P07550" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "P07550", "url": 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}, { "id": "R-HSA-390696", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-390696", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-8856825", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8856825", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-8856828", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8856828", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_000015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000015", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P07550-1", "url": "https://www.uniprot.org/uniprot/P07550-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL", "length": 413, "header": "sp|P07550-1|ADRB2_HUMAN Isoform 1 of Beta-2 adrenergic receptor OS=Homo sapiens OX=9606 GN=ADRB2 PE=1 SV=3 CANONICAL=P07550-1" }, "isoforms": [ { "isoform_ac": "P07550-1", "url": "", "sequence": { "sequence": "MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL", "length": 413, "header": "sp|P07550-1|ADRB2_HUMAN Isoform 1 of Beta-2 adrenergic receptor OS=Homo sapiens OX=9606 GN=ADRB2 PE=1 SV=3 CANONICAL=P07550-1" }, "locus": { "chromosome": "5", "start_pos": 148828070, "end_pos": 148826832, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000305988.6", "url": "https://www.ensembl.org/id/ENST00000305988.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000305372.4", "url": "https://www.ensembl.org/id/ENSP00000305372.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", 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"https://research.bioinformatics.udel.edu/glyco/pmid/28467637" }, { "id": "28467637", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28467637" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "automatic_literature_mining", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 187, "start_aa": "Asn", "end_pos": 187, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn187", "evidence": [ { "id": "28467637", "database": "Automatic Literature Mining", "url": "https://research.bioinformatics.udel.edu/glyco/pmid/28467637" }, { "id": "28467637", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28467637" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 6, "start_aa": "Asn", "end_pos": 6, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn6", "evidence": [ { "id": "P07550", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07550#ptm_processing" }, { "id": "28467637", "database": "Automatic Literature Mining", "url": "https://research.bioinformatics.udel.edu/glyco/pmid/28467637" }, { "id": "28467637", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28467637" } ] } ], "phosphorylation": [ { "start_pos": 132, "end_pos": 132, "kinase_uniprot_canonical_ac": "P06213-1", "kinase_gene_name": "INSR", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P07550", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07550" }, { "database": "PubMed", "id": "8557631", "url": "https://glygen.org/publication/PubMed/8557631" } ], "site_lbl": "Tyr132" }, { "start_pos": 132, "end_pos": 132, "kinase_uniprot_canonical_ac": "P08069-1", "kinase_gene_name": "IGF1R", "residue": "Tyr", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "P07550", "url": "http://phospho.elm.eu.org/byAccession/P07550.html" }, { "database": "iPTMnet", "id": "P07550", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07550" }, { "database": "PubMed", "id": "8910597", "url": "https://glygen.org/publication/PubMed/8910597" } ], "site_lbl": "Tyr132" }, { "start_pos": 141, "end_pos": 141, "kinase_uniprot_canonical_ac": "P06213-1", "kinase_gene_name": "INSR", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P07550", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07550" }, { "database": "PubMed", "id": "8557631", "url": "https://glygen.org/publication/PubMed/8557631" } ], "site_lbl": "Tyr141" }, { "start_pos": 141, "end_pos": 141, "kinase_uniprot_canonical_ac": "P08069-1", "kinase_gene_name": "IGF1R", "residue": "Tyr", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "P07550", "url": "http://phospho.elm.eu.org/byAccession/P07550.html" }, { "database": "iPTMnet", "id": "P07550", "url": 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"https://glygen.org/publication/PubMed/17525332" }, { "database": "iPTMnet", "id": "P07550", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07550" }, { "database": "PubMed", "id": "18578522", "url": "https://glygen.org/publication/PubMed/18578522" }, { "database": "phospho.ELM", "id": "P07550", "url": "http://phospho.elm.eu.org/byAccession/P07550.html" } ], "site_lbl": "Ser246" }, { "start_pos": 261, "end_pos": 261, "kinase_uniprot_canonical_ac": "Q05655-1", "kinase_gene_name": "PRKCD", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P07550", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07550" }, { "database": "PubMed", "id": "1848190", "url": "https://glygen.org/publication/PubMed/1848190" } ], "site_lbl": "Ser261" }, { "start_pos": 261, "end_pos": 261, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PKA", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" }, { "database": "iPTMnet", "id": "P07550", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07550" }, { "database": "PubMed", "id": "24677713", "url": "https://glygen.org/publication/PubMed/24677713" }, { "database": "PubMed", "id": "27481942", "url": "https://glygen.org/publication/PubMed/27481942" }, { "database": "PubMed", "id": "27646272", "url": "https://glygen.org/publication/PubMed/27646272" } ], "site_lbl": "Ser261" }, { "start_pos": 262, "end_pos": 262, "kinase_uniprot_canonical_ac": "Q05655-1", "kinase_gene_name": "PRKCD", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P07550", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P07550" }, { "database": "PubMed", "id": "1848190", "url": "https://glygen.org/publication/PubMed/1848190" } ], "site_lbl": "Ser262" }, { "start_pos": 262, "end_pos": 262, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", 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"name": "clathrin-coated endocytic vesicle membrane", "id": "GO:0030669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030669", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 33, "go_terms": [ { "name": "smooth muscle contraction", "id": "GO:0006939", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006939", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "activation of transmembrane receptor protein tyrosine kinase activity", "id": "GO:0007171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007171", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "activation of adenylate cyclase activity", "id": "GO:0007190", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007190", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "response to cold", "id": "GO:0009409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009409", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "positive regulation of protein kinase A signaling", "id": "GO:0010739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010739", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "positive regulation of MAPK cascade", "id": "GO:0043410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043410", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "brown fat cell differentiation", "id": "GO:0050873", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050873", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "adenylate cyclase-activating adrenergic receptor signaling pathway", "id": "GO:0071880", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071880", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "cellular response to amyloid-beta", "id": "GO:1904646", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904646", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "id": "GO:0007188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007188", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "regulation of sodium ion transport", "id": "GO:0002028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002028", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "endosome to lysosome transport", "id": "GO:0008333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008333", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "diet induced thermogenesis", "id": "GO:0002024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002024", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure", "id": "GO:0002025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002025", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "desensitization of G protein-coupled receptor signaling pathway by arrestin", "id": "GO:0002032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002032", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "receptor-mediated endocytosis", "id": "GO:0006898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006898", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "positive regulation of bone mineralization", "id": "GO:0030501", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030501", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "heat generation", "id": "GO:0031649", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031649", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "negative regulation of multicellular organism growth", "id": "GO:0040015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0040015", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "bone resorption", "id": "GO:0045453", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045453", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "negative regulation of smooth muscle contraction", "id": "GO:0045986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045986", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "positive regulation of mini excitatory postsynaptic potential", "id": "GO:0061885", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061885", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "adrenergic receptor signaling pathway", "id": "GO:0071875", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071875", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "positive regulation of autophagosome maturation", "id": "GO:1901098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901098", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "positive regulation of lipophagy", "id": "GO:1904504", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904504", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "response to psychosocial stress", "id": "GO:1990911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990911", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "positive regulation of cAMP-dependent protein kinase activity", "id": "GO:2000481", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000481", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "positive regulation of AMPA receptor activity", "id": "GO:2000969", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000969", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "positive regulation of protein serine/threonine kinase activity", "id": "GO:0071902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071902", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "transcription by RNA polymerase II", "id": "GO:0006366", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006366", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "positive regulation of cold-induced thermogenesis", "id": "GO:0120162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120162", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "amyloid-beta binding", "id": "GO:0001540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001540", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "potassium channel regulator activity", "id": "GO:0015459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015459", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "adenylate cyclase binding", "id": "GO:0008179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008179", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "protein-containing complex binding", "id": "GO:0044877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "norepinephrine binding", "id": "GO:0051380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051380", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" } ], "pmid": "" }, { "name": "beta2-adrenergic receptor activity", "id": 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Mainly palmitoylated at Cys-341 (PubMed:2540197, PubMed:17962520, PubMed:18547522). Palmitoylation may reduce accessibility of phosphorylation sites by anchoring the receptor to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation (PubMed:11146000). Also undergoes transient, ligand-induced palmitoylation at Cys-265 probably by ZDHHC9, ZDHHC14 and ZDHHC18 within the Golgi (PubMed:27481942). Palmitoylation at Cys-265 requires phosphorylation by PKA and receptor internalization and stabilizes the receptor (PubMed:27481942). Could be depalmitoylated by LYPLA1 at the plasma membrane (PubMed:27481942).", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" }, { "database": "PubMed", "id": "17962520", "url": "https://glygen.org/publication/PubMed/17962520" }, { "database": "PubMed", "id": "18547522", "url": "https://glygen.org/publication/PubMed/18547522" }, { "database": "PubMed", "id": "11146000", "url": "https://glygen.org/publication/PubMed/11146000" }, { "database": "PubMed", "id": "2540197", "url": "https://glygen.org/publication/PubMed/2540197" }, { "database": "PubMed", "id": "27481942", "url": "https://glygen.org/publication/PubMed/27481942" } ] }, { "annotation": "Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor.", "evidence": [ { "database": "UniProtKB", "id": "P07550", "url": "https://www.uniprot.org/uniprot/P07550" }, { "database": "PubMed", "id": "8521811", "url": "https://glygen.org/publication/PubMed/8521811" } ] }, { "annotation": "Polyubiquitinated (PubMed:23166351). Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation (PubMed:19424180, PubMed:20559325, PubMed:23166351). Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation. 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