{ "uniprot_canonical_ac": "P06870-1", "uniprot_ac": "P06870", "uniprot_id": "KLK1_HUMAN", "mass": { "chemical_mass": 28890.0, "monoisotopic_mass": 28890.0 }, "refseq": { "ac": "NP_002248", "name": "kallikrein-1 preproprotein", "summary": "Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002248" }, "gene_names": [ { "name": "KLK1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P06870", "id": "P06870" }, { "name": "KLK1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002248", "id": "NP_002248" }, { "name": "hK1; Klk6; KLKR", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002248", "id": "NP_002248" } ], "protein_names": [ { "name": "Kallikrein-1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P06870" }, { "name": "3.4.21.35", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P06870" }, { "name": "Kidney/pancreas/salivary gland kallikrein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P06870" }, { "name": "Tissue kallikrein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P06870" }, { "name": "kallikrein 1, renal/pancreas/salivary; tissue kallikrein; kallikrein serine protease 1; glandular kallikrein 1; kidney/pancreas/salivary gland kallikrein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002248", "id": "NP_002248" }, { "name": "kallikrein-1 preproprotein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002248", "id": "NP_002248" } ], "function": [ { "annotation": "(Microbial infection) Cleaves Neisseria meningitidis NHBA in saliva; Neisseria is an obligate commensal of the nasopharyngeal mucosa.", "evidence": [ { "database": "UniProtKB", "id": "P06870", "url": "https://www.uniprot.org/uniprot/P06870#function" }, { "database": "PubMed", "id": "31369555", "url": "https://glygen.org/publication/PubMed/31369555" } ] }, { "annotation": "Associations of ACE I/D polymorphism with the levels of ACE, kallikrein, angiotensin II and interleukin-6 in STEMI patients. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_002248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002248" }, { "database": "PubMed", "id": "31873176", "url": "https://glygen.org/publication/PubMed/31873176" } ] }, { "annotation": "Coexpression of tissue kallikrein 1 and tissue inhibitor of matrix metalloproteinase 1 improves myocardial ischemiareperfusion injury by promoting angiogenesis and inhibiting oxidative stress.", "evidence": [ { "database": "RefSeq", "id": "NP_002248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002248" }, { "database": "PubMed", "id": "33355364", "url": "https://glygen.org/publication/PubMed/33355364" } ] }, { "annotation": "Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.", "evidence": [ { "database": "UniProtKB", "id": "P06870", "url": "https://www.uniprot.org/uniprot/P06870#function" } ] }, { "annotation": "Kallikrein directly interacts with and activates Factor IX, resulting in thrombin generation and fibrin formation independent of Factor XI.", "evidence": [ { "database": "RefSeq", "id": "NP_002248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002248" }, { "database": "PubMed", "id": "33397811", "url": "https://glygen.org/publication/PubMed/33397811" } ] }, { "annotation": "Kallikrein has an apple domain disc with a rotated conformation compared to factor XI", "evidence": [ { "database": "RefSeq", "id": "NP_002248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002248" }, { "database": "PubMed", "id": "30801944", "url": "https://glygen.org/publication/PubMed/30801944" } ] }, { "annotation": "Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_002248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002248" } ] }, { "annotation": "The findings indicate that KLK1 intervenes early in the antiviral defense modulating the severity of influenza infection. Decreased KLK1 expression in Chronic obstructive pulmonary disease patients could contribute to the worsening of influenza.", "evidence": [ { "database": "RefSeq", "id": "NP_002248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002248" }, { "database": "PubMed", "id": "30908937", "url": "https://glygen.org/publication/PubMed/30908937" } ] } ], "disease": [ { "disease_id": "MONDO:0014415", "recommended_name": { "id": "MONDO:0014415", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014415", "name": "kallikrein, decreased urinary activity of", "description": "" }, "synonyms": [ { "id": "MONDO:0014415", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014415", "name": "kallikrein, decreased urinary activity of", "description": "" } ], "evidence": [ { "id": "615953", "database": "MIM", "url": "https://www.omim.org/entry/615953" } ] } ], "snv": [ { "evidence": [ { "id": "rs1475630231", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1475630231" }, { "id": "rs1475630231", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1475630231" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 167, "end_pos": 167, "sequence_org": "S", "sequence_mut": "L", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NFS->NFL); o-glyco-site-loss (S->L).", "chr_id": "19", "chr_pos": "50820032", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S167", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "P06870", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P06870" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 109, "end_pos": 109, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "H", "sequence_mut": "P", "comment": "Somatic mutation passed 1 out of 6 filters: 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"description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi" ] }, { "evidence": [ { "id": "rs1475954682", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1475954682" }, { "id": "rs1475954682", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1475954682#frequency_tab" }, { "id": "rs1475954682", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1475954682" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 110, "end_pos": 110, "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NHT->NHN).", 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"description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL 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"name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, 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"http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric 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"name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant 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"https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "P06870", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06870" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06870" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine 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"resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine 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"MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "P06870", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06870" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P06870", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06870" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "P06870", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06870" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "P06870", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06870" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Uterine cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:363", "evidence": [ { "database": "BioXpress", "id": "P06870", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06870" } ], "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P06870", "url": "https://www.uniprot.org/uniprot/P06870" } ], "common_name": "Human" } ], "gene": [ { "name": "KLK1", "url": "https://www.uniprot.org/uniprot/P06870", "locus": { "chromosome": "19", "start_pos": 50819146, "end_pos": 50823787, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000167748", "url": "https://www.ensembl.org/id/ENSG00000167748" } ] } } ], "crossref": [ { "id": "ENSG00000167748", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000167748", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "P06870", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P06870", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "3.4.21.35", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.21.35&UniProtAcc=P06870", "database": 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"https://www.ebi.ac.uk/interpro/entry/IPR001254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:3816", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:3816", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "147910", "url": "http://www.omim.org/entry/147910", "database": "MIM", "categories": [ "Other" ] }, { "id": "615953", "url": "http://www.omim.org/entry/615953", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_P06870", "url": "https://www.nextprot.org/entry/NX_P06870", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "FMLCAGQ", "url": "https://omabrowser.org/oma/group/FMLCAGQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4629979at2759", "url": "http://www.orthodb.org/?query=4629979at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24271", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24271", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24271:SF47", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24271:SF47", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "1SPJ", "url": "https://www.rcsb.org/structure/1SPJ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00089", "url": "http://pfam.xfam.org/family/PF00089", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P06870", "url": "https://pharos.nih.gov/targets/P06870", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR:000053596", "url": "https://proconsortium.org/app/entry/PR:000053596", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053597", "url": "https://proconsortium.org/app/entry/PR:000053597", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053598", "url": "https://proconsortium.org/app/entry/PR:000053598", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053599", "url": "https://proconsortium.org/app/entry/PR:000053599", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053600", "url": "https://proconsortium.org/app/entry/PR:000053600", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053601", "url": "https://proconsortium.org/app/entry/PR:000053601", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053602", "url": "https://proconsortium.org/app/entry/PR:000053602", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053603", "url": "https://proconsortium.org/app/entry/PR:000053603", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053604", "url": "https://proconsortium.org/app/entry/PR:000053604", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053605", "url": "https://proconsortium.org/app/entry/PR:000053605", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053606", "url": "https://proconsortium.org/app/entry/PR:000053606", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053607", "url": "https://proconsortium.org/app/entry/PR:000053607", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053608", "url": "https://proconsortium.org/app/entry/PR:000053608", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053609", "url": "https://proconsortium.org/app/entry/PR:000053609", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053610", "url": "https://proconsortium.org/app/entry/PR:000053610", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053611", "url": "https://proconsortium.org/app/entry/PR:000053611", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053612", "url": "https://proconsortium.org/app/entry/PR:000053612", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053613", "url": "https://proconsortium.org/app/entry/PR:000053613", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053614", "url": "https://proconsortium.org/app/entry/PR:000053614", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053615", "url": "https://proconsortium.org/app/entry/PR:000053615", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053616", "url": "https://proconsortium.org/app/entry/PR:000053616", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053617", "url": "https://proconsortium.org/app/entry/PR:000053617", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053618", "url": "https://proconsortium.org/app/entry/PR:000053618", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053619", "url": "https://proconsortium.org/app/entry/PR:000053619", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053620", "url": "https://proconsortium.org/app/entry/PR:000053620", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053621", "url": "https://proconsortium.org/app/entry/PR:000053621", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053622", "url": "https://proconsortium.org/app/entry/PR:000053622", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053623", "url": "https://proconsortium.org/app/entry/PR:000053623", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053624", "url": "https://proconsortium.org/app/entry/PR:000053624", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053625", "url": "https://proconsortium.org/app/entry/PR:000053625", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053626", "url": "https://proconsortium.org/app/entry/PR:000053626", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053627", "url": "https://proconsortium.org/app/entry/PR:000053627", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053628", "url": "https://proconsortium.org/app/entry/PR:000053628", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053629", "url": "https://proconsortium.org/app/entry/PR:000053629", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053630", "url": "https://proconsortium.org/app/entry/PR:000053630", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053631", "url": "https://proconsortium.org/app/entry/PR:000053631", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053632", "url": "https://proconsortium.org/app/entry/PR:000053632", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053633", "url": "https://proconsortium.org/app/entry/PR:000053633", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053634", "url": "https://proconsortium.org/app/entry/PR:000053634", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053635", "url": "https://proconsortium.org/app/entry/PR:000053635", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053636", "url": "https://proconsortium.org/app/entry/PR:000053636", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053637", "url": "https://proconsortium.org/app/entry/PR:000053637", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053638", "url": "https://proconsortium.org/app/entry/PR:000053638", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053639", "url": "https://proconsortium.org/app/entry/PR:000053639", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000053640", "url": "https://proconsortium.org/app/entry/PR:000053640", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR_P06870", "url": "http://purl.obolibrary.org/obo/PR_P06870", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_002248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002248", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P06870", "url": "DISABLED", "database": "UniCarbKB", "categories": [ "Glycoproteomics" ] }, { "id": "M0R318", "url": "https://www.uniprot.org/uniprot/M0R318", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M0R318-1", "url": "https://www.uniprot.org/uniprot/M0R318-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P06870", "url": "https://www.uniprot.org/uniprot/P06870", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P06870-1", "url": "https://www.uniprot.org/uniprot/P06870-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P06870-2", "url": "https://www.uniprot.org/uniprot/P06870-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS", "length": 262, "header": "sp|P06870-1|KLK1_HUMAN Isoform 1 of Kallikrein-1 OS=Homo sapiens OX=9606 GN=KLK1 PE=1 SV=2 CANONICAL=P06870-1" }, "isoforms": [ { "isoform_ac": "M0R318-1", "url": "", "sequence": { "sequence": "MWFLVLCLALSLGGTALVFWNPTPRILNAFSASASALASPKIASKRTPYPSSTLRP", "length": 56, "header": "tr|M0R318-1|M0R318_HUMAN Computationally mapped isoform of Kallikrein 1 OS=Homo sapiens OX=9606 GN=KLK1 PE=4 SV=1 CANONICAL=P06870-1" }, "locus": { "chromosome": "19", "start_pos": 50823748, "end_pos": 50822730, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000593325.5", "url": "https://www.ensembl.org/id/ENST00000593325.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000472939.1", "url": "https://www.ensembl.org/id/ENSP00000472939.1" } ] } }, { "isoform_ac": "P06870-1", "url": "", "sequence": { "sequence": "MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS", "length": 262, "header": "sp|P06870-1|KLK1_HUMAN Isoform 1 of Kallikrein-1 OS=Homo sapiens OX=9606 GN=KLK1 PE=1 SV=2 CANONICAL=P06870-1" }, "locus": { "chromosome": "19", "start_pos": 50823748, "end_pos": 50819197, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000301420.3", "url": "https://www.ensembl.org/id/ENST00000301420.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000301420.1", "url": "https://www.ensembl.org/id/ENSP00000301420.1" } ] } }, { "isoform_ac": "P06870-2", "url": "", "sequence": { "sequence": "MLPCPIPFSPSRLLIPPFPSFPSNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS", "length": 216, "header": "sp|P06870-2|KLK1_HUMAN Isoform 2 of Kallikrein-1 OS=Homo sapiens OX=9606 GN=KLK1 PE=1 SV=2 CANONICAL=P06870-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "G09150LP", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 102, "start_aa": "Asn", "end_pos": 102, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn102", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G09482NW", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 102, "start_aa": "Asn", "end_pos": 102, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn102", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G20170YB", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 102, "start_aa": "Asn", "end_pos": 102, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn102", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G23484GM", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 102, "start_aa": "Asn", "end_pos": 102, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn102", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G25350TT", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 102, "start_aa": "Asn", "end_pos": 102, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn102", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G29377XJ", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 102, "start_aa": "Asn", "end_pos": 102, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn102", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G59361OW", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 102, "start_aa": "Asn", "end_pos": 102, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn102", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G60963AS", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 102, "start_aa": "Asn", "end_pos": 102, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn102", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G63065KG", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 102, "start_aa": "Asn", "end_pos": 102, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn102", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G72221XM", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 102, "start_aa": "Asn", "end_pos": 102, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn102", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G85542KD", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 102, "start_aa": "Asn", "end_pos": 102, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn102", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G88417ED", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 102, "start_aa": "Asn", "end_pos": 102, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn102", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G88461FF", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 102, "start_aa": "Asn", "end_pos": 102, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn102", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G88948CY", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 102, "start_aa": "Asn", "end_pos": 102, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn102", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G96063MG", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 102, "start_aa": "Asn", "end_pos": 102, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn102", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 102, "start_aa": "Asn", "end_pos": 102, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn102", "evidence": [ { "id": "P06870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06870#ptm_processing" }, { "id": "3163150", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/3163150" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-GalNAcylation", "site_category": "reported", "site_seq": "S", "relation": "attached", "comment": "O-linked (GalNAc...) serine O-GalNAcylation", "start_pos": 104, "start_aa": "Ser", "end_pos": 104, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser104", "evidence": [ { "id": "P06870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06870#ptm_processing" }, { "id": "3163150", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/3163150" } ] }, { "glytoucan_ac": "G09150LP", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 108, "start_aa": "Asn", "end_pos": 108, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn108", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G09482NW", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 108, "start_aa": "Asn", "end_pos": 108, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn108", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G20170YB", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 108, "start_aa": "Asn", "end_pos": 108, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn108", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G23484GM", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 108, "start_aa": "Asn", "end_pos": 108, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn108", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G25350TT", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 108, "start_aa": "Asn", "end_pos": 108, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn108", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G29377XJ", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 108, "start_aa": "Asn", "end_pos": 108, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn108", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G59361OW", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 108, "start_aa": "Asn", "end_pos": 108, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn108", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G60963AS", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 108, "start_aa": "Asn", "end_pos": 108, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn108", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G63065KG", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 108, "start_aa": "Asn", "end_pos": 108, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn108", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G72221XM", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 108, "start_aa": "Asn", "end_pos": 108, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn108", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G85542KD", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 108, "start_aa": "Asn", "end_pos": 108, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn108", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G88417ED", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 108, "start_aa": "Asn", "end_pos": 108, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn108", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G88461FF", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 108, "start_aa": "Asn", "end_pos": 108, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn108", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G88948CY", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 108, "start_aa": "Asn", "end_pos": 108, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn108", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G96063MG", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 108, "start_aa": "Asn", "end_pos": 108, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn108", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 108, "start_aa": "Asn", "end_pos": 108, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn108", "evidence": [ { "id": "P06870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06870#ptm_processing" }, { "id": "15651049", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/15651049" }, { "id": "3163150", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/3163150" } ] }, { "glytoucan_ac": "G09150LP", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 165, "start_aa": "Asn", "end_pos": 165, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn165", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G09482NW", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 165, "start_aa": "Asn", "end_pos": 165, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn165", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G20170YB", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 165, "start_aa": "Asn", "end_pos": 165, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn165", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G23484GM", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 165, "start_aa": "Asn", "end_pos": 165, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn165", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G25350TT", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 165, "start_aa": "Asn", "end_pos": 165, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn165", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G29377XJ", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 165, "start_aa": "Asn", "end_pos": 165, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn165", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G59361OW", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 165, "start_aa": "Asn", "end_pos": 165, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn165", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G60963AS", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 165, "start_aa": "Asn", "end_pos": 165, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn165", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G63065KG", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 165, "start_aa": "Asn", "end_pos": 165, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn165", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G72221XM", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 165, "start_aa": "Asn", "end_pos": 165, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn165", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G85542KD", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 165, "start_aa": "Asn", "end_pos": 165, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn165", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G88417ED", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 165, "start_aa": "Asn", "end_pos": 165, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn165", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G88461FF", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 165, "start_aa": "Asn", "end_pos": 165, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn165", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G88948CY", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: N-102, N-108, N-165", "start_pos": 165, "start_aa": "Asn", "end_pos": 165, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn165", "evidence": [ { "id": "P06870", "database": "UniCarbKB", "url": "" }, { "id": "8416919", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8416919" } ] }, { "glytoucan_ac": "G96063MG", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "GlycoSuiteDB curation notes. 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19q13.3-q13.4.", "journal": "Biochem. Biophys. Res. 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"length": 261 }, "evidence": [ { "id": "45934250", "url": "http://www.informatics.jax.org/homology/45934250", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P00756-1", "protein_name": "Kallikrein 1-related peptidase b3", "gene_name": "Klk1b3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWFLILFLALSLGGIDAAPPVQSRIVGGFKCEKNSQPWHVAVYRYTQYLCGGVLLDPNWVLTAAHCYDDNYKVWLGKNNLFKDEPSAQHRFVSKAIPHPGFNMSLMRKHIRFLEYDYSNDLMLLRLSKPADITDTVKPITLPTEEPKLGSTCLASGWGSITPTKFQFTDDLYCVNLKLLPNEDCAKAHIEKVTDAMLCAGEMDGGKDTCKGDSGGPLICDGVLQGITSWGHTPCGEPDMPGVYTKLNKFTSWIKDTMAKNP", "length": 261 }, "evidence": [ { "id": "45934260", "url": "http://www.informatics.jax.org/homology/45934260", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P00757-1", "protein_name": "Kallikrein 1-related peptidase-like b4", "gene_name": "Klk1b4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWFLILFLALSLGGIDAAPPVQSQVDCENSQPWHVAVYRFNKYQCGGVLLDRNWVLTAAHCYNDKYQVWLGKNNFLEDEPSDQHRLVSKAIPHPDFNMSLLNEHTPQPEDDYSNDLMLLRLSKPADITDVVKPITLPTEEPKLGSTCLASGWGSTTPIKFKYPDDLQCVNLKLLPNEDCDKAHEMKVTDAMLCAGEMDGGSYTCEHDSGGPLICDGILQGITSWGPEPCGEPTEPSVYTKLIKFSSWIRETMANNP", "length": 256 }, "evidence": [ { "id": "45934252", "url": "http://www.informatics.jax.org/homology/45934252", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P00758-1", "protein_name": "Kallikrein-1", "gene_name": "Ngfg", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWFLILFLALSLGRNDAAPPVQSRVVGGYNCEMNSQPWQVAVYYFGEYLCGGVLIDPSWVITAAHCATDNYQVWLGRNNLYEDEPFAQHRLVSQSFPHPGFNQDLIWNHTRQPGDDYSNDLMLLHLSQPADITDGVKVIDLPIEEPKVGSTCLASGWGSITPDGLELSDDLQCVNIDLLSNEKCVEAHKEEVTDLMLCAGEMDGGKDTCKGDSGGPLICNGVLQGITSWGFNPCGEPKKPGIYTKLIKFTPWIKEVMKENP", "length": 261 }, "evidence": [ { "id": "45934254", "url": "http://www.informatics.jax.org/homology/45934254", "database": "MGI" }, { "id": "45934261", "url": "http://www.informatics.jax.org/homology/45934261", "database": "MGI" }, { "id": "45934257", "url": "http://www.informatics.jax.org/homology/45934257", "database": "MGI" }, { "id": "45934251", "url": "http://www.informatics.jax.org/homology/45934251", "database": "MGI" }, { "id": "45934247", "url": "http://www.informatics.jax.org/homology/45934247", "database": "MGI" }, { "id": "45934260", "url": "http://www.informatics.jax.org/homology/45934260", "database": "MGI" }, { "id": "45934259", "url": "http://www.informatics.jax.org/homology/45934259", "database": "MGI" }, { "id": "45934255", "url": "http://www.informatics.jax.org/homology/45934255", "database": "MGI" }, { "id": "45934256", "url": "http://www.informatics.jax.org/homology/45934256", "database": "MGI" }, { "id": "45934250", "url": "http://www.informatics.jax.org/homology/45934250", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P00759-1", "protein_name": "Tonin", "gene_name": "Klk2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWLQILSLVLSVGRIDAAPPGQSRIVGGYKCEKNSQPWQVAVINEYLCGGVLIDPSWVITAAHCYSNNYQVLLGRNNLFKDEPFAQRRLVRQSFRHPDYIPLIVTNDTEQPVHDHSNDLMLLHLSEPADITGGVKVIDLPTKEPKVGSTCLASGWGSTNPSEMVVSHDLQCVNIHLLSNEKCIETYKDNVTDVMLCAGEMEGGKDTCAGDSGGPLICDGVLQGITSGGATPCAKPKTPAIYAKLIKFTSWIKKVMKENP", "length": 259 }, "evidence": [ { "id": "45934254", "url": "http://www.informatics.jax.org/homology/45934254", "database": "MGI" }, { "id": "45934261", "url": "http://www.informatics.jax.org/homology/45934261", "database": "MGI" }, { "id": "45934257", "url": "http://www.informatics.jax.org/homology/45934257", "database": "MGI" }, { "id": "45934251", "url": "http://www.informatics.jax.org/homology/45934251", "database": "MGI" }, { "id": "45934249", "url": "http://www.informatics.jax.org/homology/45934249", "database": "MGI" }, { "id": "45934248", "url": "http://www.informatics.jax.org/homology/45934248", "database": "MGI" }, { "id": "45934247", "url": "http://www.informatics.jax.org/homology/45934247", "database": "MGI" }, { "id": "45934260", "url": "http://www.informatics.jax.org/homology/45934260", "database": "MGI" }, { "id": "45934259", "url": "http://www.informatics.jax.org/homology/45934259", "database": "MGI" }, { "id": "45934253", "url": "http://www.informatics.jax.org/homology/45934253", "database": "MGI" }, { "id": "45934258", "url": "http://www.informatics.jax.org/homology/45934258", "database": "MGI" }, { "id": "45934255", "url": "http://www.informatics.jax.org/homology/45934255", "database": "MGI" }, { "id": "45934256", "url": "http://www.informatics.jax.org/homology/45934256", "database": "MGI" }, { "id": "45934250", "url": "http://www.informatics.jax.org/homology/45934250", "database": "MGI" }, { "id": "45934252", "url": "http://www.informatics.jax.org/homology/45934252", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P04071-1", "protein_name": "Kallikrein 1-related peptidase b16", "gene_name": "Klk1b16", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWFLILFLALSLGGIDAAPPVQSRIVGGFKCEKNSQPWQVAVYYHKEHICGGVLLDRNWVLTAAHCYVDECEVWLGKNQLFQEEPSAQNRLVSKSFPHPGFNMTLLTFEKLPPGADFSNDLMLLRLSKPADITDVVKPIDLPTKEPKLDSTCLVSGWGSITPTKWQKPDDLQCMFTKLLPNENCAKAYLLKVTDVMLCTIEMGEDKGPCVGDSGGPLICDGVLQGTVSIGPDPCGIPGVSAIYTNLVKFNSWIKDTMMKNA", "length": 261 }, "evidence": [ { "id": "45934253", "url": "http://www.informatics.jax.org/homology/45934253", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P07288-1", "protein_name": "Prostate-specific antigen", "gene_name": "KLK3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWVPVVFLTLSVTWIGAAPLILSRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWVLTAAHCIRNKSVILLGRHSLFHPEDTGQVFQVSHSFPHPLYDMSLLKNRFLRPGDDSSHDLMLLRLSEPAELTDAVKVMDLPTQEPALGTTCYASGWGSIEPEEFLTPKKLQCVDLHVISNDVCAQVHPQKVTKFMLCAGRWTGGKSTCSGDSGGPLVCNGVLQGITSWGSEPCALPERPSLYTKVVHYRKWIKDTIVANP", "length": 261 }, "evidence": [ { "id": "45934254", "url": "http://www.informatics.jax.org/homology/45934254", "database": "MGI" }, { "id": "45934261", "url": "http://www.informatics.jax.org/homology/45934261", "database": "MGI" }, { "id": "45934257", "url": "http://www.informatics.jax.org/homology/45934257", "database": "MGI" }, { "id": "45934251", "url": "http://www.informatics.jax.org/homology/45934251", "database": "MGI" }, { "id": "45934249", "url": "http://www.informatics.jax.org/homology/45934249", "database": "MGI" }, { "id": "45934247", "url": "http://www.informatics.jax.org/homology/45934247", "database": "MGI" }, { "id": "45934260", "url": "http://www.informatics.jax.org/homology/45934260", "database": "MGI" }, { "id": "45934259", "url": "http://www.informatics.jax.org/homology/45934259", "database": "MGI" }, { "id": "45934253", "url": "http://www.informatics.jax.org/homology/45934253", "database": "MGI" }, { "id": "45934258", "url": "http://www.informatics.jax.org/homology/45934258", "database": "MGI" }, { "id": "45934255", "url": "http://www.informatics.jax.org/homology/45934255", "database": "MGI" }, { "id": "45934256", "url": "http://www.informatics.jax.org/homology/45934256", "database": "MGI" }, { "id": "45934250", "url": "http://www.informatics.jax.org/homology/45934250", "database": "MGI" }, { "id": "45934252", "url": "http://www.informatics.jax.org/homology/45934252", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "P07628-1", "protein_name": "Kallikrein 1-related peptidase b8", "gene_name": "Klk1b8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRFLILFLALSLGGIDAAPPLQSRVVGGFNCEKNSQPWQVAVYDNKEHICGGVLLERNWVLTAAHCYVDQYEVWLGKNKLFQEEPSAQHRLVSKSFPHPGFNMSLLTLKEIPPGADFSNDLMLLRLSKPADITDAVKPITLPTKESKLGSTCLASGWGSITPTKWQKPDDLQCVFLKLLPIKNCIENHNVKVTDVMLCAGEMSGGKNICKGDSGGPLICDSVLQGITSTGPIPCGKPGVPAMYTNLIKFNSWIKDTMTKNS", "length": 261 }, "evidence": [ { "id": "45934258", "url": "http://www.informatics.jax.org/homology/45934258", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P07647-1", "protein_name": "Submandibular glandular kallikrein-9", "gene_name": "Klk9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWFLILFLALSLGQIDAAPPGQSRVVGGYNCETNSQPWQVAVIGTTFCGGVLIDPSWVITAAHCYSKNYRVLLGRNNLVKDEPFAQRRLVSQSFQHPDYIPVFMRNHTRQRAYDHNNDLMLLHLSKPADITGGVKVIDLPTEEPKVGSICLASGWGMTNPSEMKLSHDLQCVNIHLLSNEKCIETYKNIETDVTLCAGEMDGGKDTCTGDSGGPLICDGVLQGLTSGGATPCAKPKTPAIYAKLIKFTSWIKKVMKENP", "length": 259 }, "evidence": [ { "id": "45934254", "url": "http://www.informatics.jax.org/homology/45934254", "database": "MGI" }, { "id": "45934261", "url": "http://www.informatics.jax.org/homology/45934261", "database": "MGI" }, { "id": "45934257", "url": "http://www.informatics.jax.org/homology/45934257", "database": "MGI" }, { "id": "45934251", "url": "http://www.informatics.jax.org/homology/45934251", "database": "MGI" }, { "id": "45934249", "url": "http://www.informatics.jax.org/homology/45934249", "database": "MGI" }, { "id": "45934248", "url": "http://www.informatics.jax.org/homology/45934248", "database": "MGI" }, { "id": "45934247", "url": "http://www.informatics.jax.org/homology/45934247", "database": "MGI" }, { "id": "45934260", "url": "http://www.informatics.jax.org/homology/45934260", "database": "MGI" }, { "id": "45934259", "url": "http://www.informatics.jax.org/homology/45934259", "database": "MGI" }, { "id": "45934253", "url": "http://www.informatics.jax.org/homology/45934253", "database": "MGI" }, { "id": "45934258", "url": "http://www.informatics.jax.org/homology/45934258", "database": "MGI" }, { "id": "45934255", "url": "http://www.informatics.jax.org/homology/45934255", "database": "MGI" }, { "id": "45934256", "url": "http://www.informatics.jax.org/homology/45934256", "database": "MGI" }, { "id": "45934250", "url": "http://www.informatics.jax.org/homology/45934250", "database": "MGI" }, { "id": "45934252", "url": "http://www.informatics.jax.org/homology/45934252", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P15945-1", "protein_name": "Kallikrein 1-related peptidase b5", "gene_name": "Klk1b5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWFLILFLALSLGGIDAAPPVQSRIFGGFNCEKNSQPWQVAVYRFTKYQCGGVLLNANWVLTAAHCHNDKYQVWLGKNNFFEDEPSAQHRLVSKAIPHPDFNMSLLNEHTPQPEDDYSNDLMLLRLKKPADITDVVKPIDLPTEEPKLGSTCLASGWGSITPVIYEPADDLQCVNFKLLPNEDCVKAHIEKVTDVMLCAGDMDGGKDTCMGDSGGPLICDGVLHGITSWGPSPCGKPNVPGIYTKLIKFNSWIKDTIAKNA", "length": 261 }, "evidence": [ { "id": "45934257", "url": "http://www.informatics.jax.org/homology/45934257", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P15946-1", "protein_name": "Kallikrein 1-related peptidase b11", "gene_name": "Klk1b11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWFLILFLALSLGGIDAAPPVQSRIVGGFNCEKNSQPWHVAVYRYNKYICGGVLLDRNWVLTAAHCHVSQYNVWLGKTKLFQREPSAQHRMVSKSFPHPDYNMSLLIIHNPEPEDDESNDLMLLRLSEPADITDAVKPIALPTEEPKLGSTCLVSGWGSITPTKFQTPDDLQCVSIKLLPNEVCVKNHNQKVTDVMLCAGEMGGGKDTCKGDSGGPLICDGVLHGITAWGPIPCGKPNTPGVYTKLIKFTNWIKDTMAKNP", "length": 261 }, "evidence": [ { "id": "45934259", "url": "http://www.informatics.jax.org/homology/45934259", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P15947-1", "protein_name": "Kallikrein-1", "gene_name": "Klk1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRFLILFLALSLGGIDAAPPVQSRIVGGFNCEKNSQPWQVAVYRFTKYQCGGILLNANWVLTAAHCHNDKYQVWLGKNNFLEDEPSAQHRLVSKAIPHPDFNMSLLNEHTPQPEDDYSNDLMLLRLKKPADITDVVKPIDLPTEEPKLGSTCLASGWGSITPVKYEYPDELQCVNLKLLPNEDCAKAHIEKVTDDMLCAGDMDGGKDTCAGDSGGPLICDGVLQGITSWGPSPCGKPNVPGIYTRVLNFNTWIRETMAEND", "length": 261 }, "evidence": [ { "id": "45934247", "url": "http://www.informatics.jax.org/homology/45934247", "database": "MGI" }, { "id": "P06870", "url": "https://omabrowser.org/oma/group/P06870/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P15948-1", "protein_name": "Kallikrein 1-related peptidase b22", "gene_name": "Klk1b22", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRFLILFLTLSLGGIDAAPPVQSRILGGFKCEKNSQPWQVAVYYLDEYLCGGVLLDRNWVLTAAHCYEDKYNIWLGKNKLFQDEPSAQHRLVSKSFPHPDFNMSLLQSVPTGADLSNDLMLLRLSKPADITDVVKPIDLPTTEPKLGSTCLASGWGSINQLIYQNPNDLQCVSIKLHPNEVCVKAHILKVTDVMLCAGEMNGGKDTCKGDSGGPLICDGVLQGITSWGSTPCGEPNAPAIYTKLIKFTSWIKDTMAKNP", "length": 259 }, "evidence": [ { "id": "45934251", "url": "http://www.informatics.jax.org/homology/45934251", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P15949-1", "protein_name": "Kallikrein 1-related peptidase b9", "gene_name": "Klk1b9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRFLILFLALSLGGIDAAPPVHSRIVGGFKCEKNSQPWHVAVYRYNEYICGGVLLDANWVLTAAHCYYEENKVSLGKNNLYEEEPSAQHRLVSKSFLHPGYNRSLHRNHIRHPEYDYSNDLMLLRLSKPADITDVVKPIALPTEEPKLGSTCLASGWGSTTPFKFQNAKDLQCVNLKLLPNEDCGKAHIEKVTDVMLCAGETDGGKDTCKGDSGGPLICDGVLQGITSWGFTPCGEPKKPGVYTKLIKFTSWIKDTMAKNL", "length": 261 }, "evidence": [ { "id": "45934254", "url": "http://www.informatics.jax.org/homology/45934254", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P20151-1", "protein_name": "Kallikrein-2", "gene_name": "KLK2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKNSQVWLGRHNLFEPEDTGQRVPVSHSFPHPLYNMSLLKHQSLRPDEDSSHDLMLLRLSEPAKITDVVKVLGLPTQEPALGTTCYASGWGSIEPEEFLRPRSLQCVSLHLLSNDMCARAYSEKVTEFMLCAGLWTGGKDTCGGDSGGPLVCNGVLQGITSWGPEPCALPEKPAVYTKVVHYRKWIKDTIAANP", "length": 261 }, "evidence": [ { "id": "45934254", "url": "http://www.informatics.jax.org/homology/45934254", "database": "MGI" }, { "id": "45934261", "url": "http://www.informatics.jax.org/homology/45934261", "database": "MGI" }, { "id": "45934257", "url": "http://www.informatics.jax.org/homology/45934257", "database": "MGI" }, { "id": "45934251", "url": "http://www.informatics.jax.org/homology/45934251", "database": "MGI" }, { "id": "45934249", "url": "http://www.informatics.jax.org/homology/45934249", "database": "MGI" }, { "id": "45934248", "url": "http://www.informatics.jax.org/homology/45934248", "database": "MGI" }, { "id": "45934247", "url": "http://www.informatics.jax.org/homology/45934247", "database": "MGI" }, { "id": "45934260", "url": "http://www.informatics.jax.org/homology/45934260", "database": "MGI" }, { "id": "45934259", "url": "http://www.informatics.jax.org/homology/45934259", "database": "MGI" }, { "id": "45934253", "url": "http://www.informatics.jax.org/homology/45934253", "database": "MGI" }, { "id": "45934258", "url": "http://www.informatics.jax.org/homology/45934258", "database": "MGI" }, { "id": "45934255", "url": "http://www.informatics.jax.org/homology/45934255", "database": "MGI" }, { "id": "45934256", "url": "http://www.informatics.jax.org/homology/45934256", "database": "MGI" }, { "id": "45934250", "url": "http://www.informatics.jax.org/homology/45934250", "database": "MGI" }, { "id": "45934252", "url": "http://www.informatics.jax.org/homology/45934252", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "P36368-1", "protein_name": "Epidermal growth factor-binding protein type B", "gene_name": "Egfbp2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWFLILFLALSLGGIDAAPPLQSRVVGGFNCKKNSQPWQVAVYYQKEHICGGVLLDRNWVLTAAHCYVDQYEVWLGKNKLFQEEPSAQHRLVSKSFPHPGFNMSLLMLQTIPPGADFSNDLMLLRLSKPADITDVVKPIALPTKEPKPGSKCLASGWGSITPTRWQKPDDLQCVFITLLPNENCAKVYLQKVTDVMLCAGEMGGGKDTCRDDSGGPLICDGILQGTTSYGPVPCGKPGVPAIYTNLIKFNSWIKDTMMKNA", "length": 261 }, "evidence": [ { "id": "45934248", "url": "http://www.informatics.jax.org/homology/45934248", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P36369-1", "protein_name": "Kallikrein 1-related peptidase b26", "gene_name": "Klk1b26", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWFLILFPALSLGGIDAAPPLQSRVVGGFNCEKNSQPWQVAVYYQKEHICGGVLLDRNWVLTAAHCYVDQYEVWLGKNKLFQEEPSAQHRLVSKSFPHPGFNMSLLMLQTTPPGADFSNDLMLLRLSKPADITDVVKPIALPTKEPKPGSTCLASGWGSITPTRWQKSDDLQCVFITLLPNENCAKVYLQKVTDVMLCAGEMGGGKDTCAGDSGGPLICDGILQGTTSNGPEPCGKPGVPAIYTNLIKFNSWIKDTMMKNA", "length": 261 }, "evidence": [ { "id": "45934261", "url": "http://www.informatics.jax.org/homology/45934261", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P36374-1", "protein_name": "Prostatic glandular kallikrein-6", "gene_name": "Klk6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWLLILFLILSLGWNDAAPPGQSRIIGGFNCEKNSQPWQVAVYHFNEPQCGGVLIHPSWVITAAHCYSVNYQVWLGRNNLLEDEPFAQHRLVSQSFPHPGFNLDIIKNHTRKPGNDYSNDLMLLHLKTPADITDGVKVIDLPTEEPKVGSTCLTSGWGSITPLKWEFPDDLQCVNIHLLSNEKCIKAYNDEVTDVMLCAGEMDGGKDICKGDSGGPLICDGVLQGITSWGSMPCGEPNKPSVYTKLIKFTSWMKKVMKENP", "length": 261 }, "evidence": [ { "id": "45934254", "url": "http://www.informatics.jax.org/homology/45934254", "database": "MGI" }, { "id": "45934261", "url": "http://www.informatics.jax.org/homology/45934261", "database": "MGI" }, { "id": "45934257", "url": "http://www.informatics.jax.org/homology/45934257", "database": "MGI" }, { "id": "45934251", "url": "http://www.informatics.jax.org/homology/45934251", "database": "MGI" }, { "id": "45934249", "url": "http://www.informatics.jax.org/homology/45934249", "database": "MGI" }, { "id": "45934248", "url": "http://www.informatics.jax.org/homology/45934248", "database": "MGI" }, { "id": "45934247", "url": "http://www.informatics.jax.org/homology/45934247", "database": "MGI" }, { "id": "45934260", "url": "http://www.informatics.jax.org/homology/45934260", "database": "MGI" }, { "id": "45934259", "url": "http://www.informatics.jax.org/homology/45934259", "database": "MGI" }, { "id": "45934253", "url": "http://www.informatics.jax.org/homology/45934253", "database": "MGI" }, { "id": "45934258", "url": "http://www.informatics.jax.org/homology/45934258", "database": "MGI" }, { "id": "45934255", "url": "http://www.informatics.jax.org/homology/45934255", "database": "MGI" }, { "id": "45934256", "url": "http://www.informatics.jax.org/homology/45934256", "database": "MGI" }, { "id": "45934250", "url": "http://www.informatics.jax.org/homology/45934250", "database": "MGI" }, { "id": "45934252", "url": "http://www.informatics.jax.org/homology/45934252", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P36375-1", "protein_name": "Glandular kallikrein-10", "gene_name": "Klk10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWFLILFLALSLGGIDAAPPGQSRIVGGYKCEKNSQPWQVAIINEYLCGGVLIDPSWVITAAHCYSNYYHVLLGRNNLFEDEPFAQYRFVNQSFPHPDYKPFLMRNHTRQRGDDYSNDLMLLHLSEPADITDGVKVIDLPTEEPKVGSTCLASGWGSTKPLNWELPDDLQCVNIHLLSNEKCIEAYEQKVTDLMLCAGEMDGRKDTCKGDSGGPLICDGVLQGITSWGNVPCAEPYNPGVYTKLIKFTSWIKEVMKENP", "length": 259 }, "evidence": [ { "id": "45934254", "url": "http://www.informatics.jax.org/homology/45934254", "database": "MGI" }, { "id": "45934261", "url": "http://www.informatics.jax.org/homology/45934261", "database": "MGI" }, { "id": "45934257", "url": "http://www.informatics.jax.org/homology/45934257", "database": "MGI" }, { "id": "45934251", "url": "http://www.informatics.jax.org/homology/45934251", "database": "MGI" }, { "id": "45934249", "url": "http://www.informatics.jax.org/homology/45934249", "database": "MGI" }, { "id": "45934248", "url": "http://www.informatics.jax.org/homology/45934248", "database": "MGI" }, { "id": "45934247", "url": "http://www.informatics.jax.org/homology/45934247", "database": "MGI" }, { "id": "45934260", "url": "http://www.informatics.jax.org/homology/45934260", "database": "MGI" }, { "id": "45934259", "url": "http://www.informatics.jax.org/homology/45934259", "database": "MGI" }, { "id": "45934253", "url": "http://www.informatics.jax.org/homology/45934253", "database": "MGI" }, { "id": "45934258", "url": "http://www.informatics.jax.org/homology/45934258", "database": "MGI" }, { "id": "45934255", "url": "http://www.informatics.jax.org/homology/45934255", "database": "MGI" }, { "id": "45934256", "url": "http://www.informatics.jax.org/homology/45934256", "database": "MGI" }, { "id": "45934250", "url": "http://www.informatics.jax.org/homology/45934250", "database": "MGI" }, { "id": "45934252", "url": "http://www.informatics.jax.org/homology/45934252", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P36376-1", "protein_name": "Glandular kallikrein-12, submandibular/renal", "gene_name": "Klk12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWLQILFLVLSVGRIDAAPPGQSRVVGGYKCEKNSQPWQVAVINRYLCGGVLIDPSWVITAAHCYSHNYHVLLGRNNLFKDEPFAQYRVVNQSFPHPDYNPFFMKNHTLFPGDDHSNDLMLLHLSEPADITDGVKVIDLPTEEPKVGSTCLASGWSSTKPLEWEFPDDLQCVNINILSNEKCIKAHTQMVTDVMLCAGELEGGKDTCNGDSGGPLLCDGVLQGITSWSSVPCGETNRPAIYTKLIKFTSWIKEVMKENS", "length": 259 }, "evidence": [ { "id": "45934254", "url": "http://www.informatics.jax.org/homology/45934254", "database": "MGI" }, { "id": "45934261", "url": "http://www.informatics.jax.org/homology/45934261", "database": "MGI" }, { "id": "45934257", "url": "http://www.informatics.jax.org/homology/45934257", "database": "MGI" }, { "id": "45934251", "url": "http://www.informatics.jax.org/homology/45934251", "database": "MGI" }, { "id": "45934249", "url": "http://www.informatics.jax.org/homology/45934249", "database": "MGI" }, { "id": "45934248", "url": "http://www.informatics.jax.org/homology/45934248", "database": "MGI" }, { "id": "45934247", "url": "http://www.informatics.jax.org/homology/45934247", "database": "MGI" }, { "id": "45934260", "url": "http://www.informatics.jax.org/homology/45934260", "database": "MGI" }, { "id": "45934259", "url": "http://www.informatics.jax.org/homology/45934259", "database": "MGI" }, { "id": "45934253", "url": "http://www.informatics.jax.org/homology/45934253", "database": "MGI" }, { "id": "45934258", "url": "http://www.informatics.jax.org/homology/45934258", "database": "MGI" }, { "id": "45934255", "url": "http://www.informatics.jax.org/homology/45934255", "database": "MGI" }, { "id": "45934256", "url": "http://www.informatics.jax.org/homology/45934256", "database": "MGI" }, { "id": "45934250", "url": "http://www.informatics.jax.org/homology/45934250", "database": "MGI" }, { "id": "45934252", "url": "http://www.informatics.jax.org/homology/45934252", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q61754-1", "protein_name": "Kallikrein 1-related peptidase b24", "gene_name": "Klk1b24", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWFLILFLALSLGGIDAAPPVQSRVVGGFKCEKNSQPWHVAVFRYNKYICGGVLLNPNWVLTAAHCYGNATSQYNVWLGKNKLFQREPSAQHRWVSKSFPHPDYNMSLLNDDIPQPKDKSNDLMLLRLSEPADITDAVKPIDLPTEEPKLGSTCLASGWGSITPTKWQKPNDLQCVFIKLLPNENCTKPYLHKVTDVMLCAGEMGGGKDTCAGDSGGPLICDGILHGITSWGPVPCGKPNAPAIYTKLIKFASWIKDTMAKNP", "length": 263 }, "evidence": [ { "id": "45934255", "url": "http://www.informatics.jax.org/homology/45934255", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q61759-1", "protein_name": "Kallikrein 1-related peptidase b21", "gene_name": "Klk1b21", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRFLILFLALSLGEIDAAPPVQSRIVGGFNCEKNSQPWHVAVFRYNKYICGGVLLNPNWVLTAAHCYGNQYNVWLGKNKLFQHESSAQHRLVSKSFPHPDYNMSLMNDHTPHPEDDYSNDLMLLRLSKPADITDAVKPIDLPTEEPKLGSTCLASGWGSITPTKWQIPNDLQCGFIKPLPNENCAKAYIHKVTDVMLCAGEMGGGKDTCAGDSGGPLICDGVLQGITSWGSIPCAKPNAPAIYTKLIKFTSWIKDTMAKNP", "length": 261 }, "evidence": [ { "id": "45934256", "url": "http://www.informatics.jax.org/homology/45934256", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9JM71-1", "protein_name": "Kallikrein 1-related peptidase b27", "gene_name": "Klk1b27", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRFLILFLALSLGGIDAAPPVQSRIIGGFKCKKNSQPWHVAVLRSNKYICGGVLLDPNWVLTAAHCYGNDTSQHNVWLGKNKLFQREPSAQHRWVSKSFPHPDYNMSLLNDHIPHPEDKSNDLMLLRLSKPADITDAVKPIDLPTEEPKLGSTCLASGWGSITPTKYQIPNDLQCVFIKLLPNENCAKAYVHKVTDVMLCVGETGGGKGTCKGDSGGPLICDGVLHGITSWGSIPCAKPNAPGVFTKLIKFTSWIKDTMAKNP", "length": 263 }, "evidence": [ { "id": "45934249", "url": "http://www.informatics.jax.org/homology/45934249", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "P06870", "url": "https://www.uniprot.org/uniprot/P06870" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "P06870", "url": "https://www.uniprot.org/uniprot/P06870" } ], "pmid": "" }, { "name": "secretory granule", "id": "GO:0030141", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030141", "evidence": [ { "database": "UniProtKB", "id": "P06870", "url": "https://www.uniprot.org/uniprot/P06870" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "P06870", "url": "https://www.uniprot.org/uniprot/P06870" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of systemic arterial blood pressure", "id": "GO:0003073", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003073", "evidence": [ { "database": "UniProtKB", "id": "P06870", "url": "https://www.uniprot.org/uniprot/P06870" } ], "pmid": "" }, { "name": "zymogen activation", "id": "GO:0031638", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031638", "evidence": [ { "database": "UniProtKB", "id": "P06870", "url": "https://www.uniprot.org/uniprot/P06870" } ], "pmid": "" } ] } ] }, "pro_annotation": [ { "name": "kallikrein-1 N-glycosylated 1 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-102 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G09150LP. Example: UniProtKB:P06870-1, Asn-102, MOD:00160~GNO:G09150LP. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053596", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053596" } ] }, { "name": "kallikrein-1 N-glycosylated 2 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-102 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G09482NW. Example: UniProtKB:P06870-1, Asn-102, MOD:00160~GNO:G09482NW. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053597", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053597" } ] }, { "name": "kallikrein-1 N-glycosylated 3 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-102 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G20170YB. Example: UniProtKB:P06870-1, Asn-102, MOD:00160~GNO:G20170YB. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053598", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053598" } ] }, { "name": "kallikrein-1 N-glycosylated 4 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-102 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G23484GM. Example: UniProtKB:P06870-1, Asn-102, MOD:00160~GNO:G23484GM. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053599", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053599" } ] }, { "name": "kallikrein-1 N-glycosylated 5 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-102 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G25350TT. Example: UniProtKB:P06870-1, Asn-102, MOD:00160~GNO:G25350TT. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053600", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053600" } ] }, { "name": "kallikrein-1 N-glycosylated 6 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-102 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G29377XJ. Example: UniProtKB:P06870-1, Asn-102, MOD:00160~GNO:G29377XJ. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053601", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053601" } ] }, { "name": "kallikrein-1 N-glycosylated 7 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-102 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G59361OW. Example: UniProtKB:P06870-1, Asn-102, MOD:00160~GNO:G59361OW. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053602", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053602" } ] }, { "name": "kallikrein-1 N-glycosylated 8 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-102 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G60963AS. Example: UniProtKB:P06870-1, Asn-102, MOD:00160~GNO:G60963AS. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053603", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053603" } ] }, { "name": "kallikrein-1 N-glycosylated 9 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-102 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G63065KG. Example: UniProtKB:P06870-1, Asn-102, MOD:00160~GNO:G63065KG. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053604", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053604" } ] }, { "name": "kallikrein-1 N-glycosylated 10 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-102 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G72221XM. Example: UniProtKB:P06870-1, Asn-102, MOD:00160~GNO:G72221XM. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053605", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053605" } ] }, { "name": "kallikrein-1 N-glycosylated 11 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-102 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G85542KD. Example: UniProtKB:P06870-1, Asn-102, MOD:00160~GNO:G85542KD. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053606", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053606" } ] }, { "name": "kallikrein-1 N-glycosylated 12 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-102 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G88417ED. Example: UniProtKB:P06870-1, Asn-102, MOD:00160~GNO:G88417ED. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053607", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053607" } ] }, { "name": "kallikrein-1 N-glycosylated 13 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-102 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G88461FF. Example: UniProtKB:P06870-1, Asn-102, MOD:00160~GNO:G88461FF. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053608", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053608" } ] }, { "name": "kallikrein-1 N-glycosylated 14 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-102 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G88948CY. Example: UniProtKB:P06870-1, Asn-102, MOD:00160~GNO:G88948CY. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053609", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053609" } ] }, { "name": "kallikrein-1 N-glycosylated 15 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-102 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G96063MG. Example: UniProtKB:P06870-1, Asn-102, MOD:00160~GNO:G96063MG. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053610", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053610" } ] }, { "name": "kallikrein-1 N-glycosylated 16 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-108 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G09150LP. Example: UniProtKB:P06870-1, Asn-108, MOD:00160~GNO:G09150LP. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053611", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053611" } ] }, { "name": "kallikrein-1 N-glycosylated 17 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-108 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G09482NW. Example: UniProtKB:P06870-1, Asn-108, MOD:00160~GNO:G09482NW. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053612", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053612" } ] }, { "name": "kallikrein-1 N-glycosylated 18 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-108 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G20170YB. Example: UniProtKB:P06870-1, Asn-108, MOD:00160~GNO:G20170YB. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053613", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053613" } ] }, { "name": "kallikrein-1 N-glycosylated 19 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-108 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G23484GM. Example: UniProtKB:P06870-1, Asn-108, MOD:00160~GNO:G23484GM. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053614", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053614" } ] }, { "name": "kallikrein-1 N-glycosylated 20 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-108 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G25350TT. Example: UniProtKB:P06870-1, Asn-108, MOD:00160~GNO:G25350TT. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053615", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053615" } ] }, { "name": "kallikrein-1 N-glycosylated 21 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-108 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G29377XJ. Example: UniProtKB:P06870-1, Asn-108, MOD:00160~GNO:G29377XJ. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053616", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053616" } ] }, { "name": "kallikrein-1 N-glycosylated 22 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-108 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G59361OW. Example: UniProtKB:P06870-1, Asn-108, MOD:00160~GNO:G59361OW. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053617", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053617" } ] }, { "name": "kallikrein-1 N-glycosylated 23 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-108 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G60963AS. Example: UniProtKB:P06870-1, Asn-108, MOD:00160~GNO:G60963AS. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053618", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053618" } ] }, { "name": "kallikrein-1 N-glycosylated 24 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-108 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G63065KG. Example: UniProtKB:P06870-1, Asn-108, MOD:00160~GNO:G63065KG. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053619", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053619" } ] }, { "name": "kallikrein-1 N-glycosylated 25 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-108 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G72221XM. Example: UniProtKB:P06870-1, Asn-108, MOD:00160~GNO:G72221XM. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053620", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053620" } ] }, { "name": "kallikrein-1 N-glycosylated 26 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-108 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G85542KD. Example: UniProtKB:P06870-1, Asn-108, MOD:00160~GNO:G85542KD. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053621", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053621" } ] }, { "name": "kallikrein-1 N-glycosylated 27 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-108 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G88417ED. Example: UniProtKB:P06870-1, Asn-108, MOD:00160~GNO:G88417ED. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053622", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053622" } ] }, { "name": "kallikrein-1 N-glycosylated 28 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-108 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G88461FF. Example: UniProtKB:P06870-1, Asn-108, MOD:00160~GNO:G88461FF. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053623", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053623" } ] }, { "name": "kallikrein-1 N-glycosylated 29 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-108 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G88948CY. Example: UniProtKB:P06870-1, Asn-108, MOD:00160~GNO:G88948CY. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053624", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053624" } ] }, { "name": "kallikrein-1 N-glycosylated 30 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-108 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G96063MG. Example: UniProtKB:P06870-1, Asn-108, MOD:00160~GNO:G96063MG. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053625", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053625" } ] }, { "name": "kallikrein-1 N-glycosylated 31 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-165 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G09150LP. Example: UniProtKB:P06870-1, Asn-165, MOD:00160~GNO:G09150LP. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053626", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053626" } ] }, { "name": "kallikrein-1 N-glycosylated 32 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-165 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G09482NW. Example: UniProtKB:P06870-1, Asn-165, MOD:00160~GNO:G09482NW. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053627", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053627" } ] }, { "name": "kallikrein-1 N-glycosylated 33 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-165 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G20170YB. Example: UniProtKB:P06870-1, Asn-165, MOD:00160~GNO:G20170YB. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053628", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053628" } ] }, { "name": "kallikrein-1 N-glycosylated 34 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-165 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G23484GM. Example: UniProtKB:P06870-1, Asn-165, MOD:00160~GNO:G23484GM. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053629", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053629" } ] }, { "name": "kallikrein-1 N-glycosylated 35 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-165 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G25350TT. Example: UniProtKB:P06870-1, Asn-165, MOD:00160~GNO:G25350TT. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053630", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053630" } ] }, { "name": "kallikrein-1 N-glycosylated 36 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-165 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G29377XJ. Example: UniProtKB:P06870-1, Asn-165, MOD:00160~GNO:G29377XJ. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053631", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053631" } ] }, { "name": "kallikrein-1 N-glycosylated 37 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-165 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G59361OW. Example: UniProtKB:P06870-1, Asn-165, MOD:00160~GNO:G59361OW. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053632", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053632" } ] }, { "name": "kallikrein-1 N-glycosylated 38 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-165 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G60963AS. Example: UniProtKB:P06870-1, Asn-165, MOD:00160~GNO:G60963AS. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053633", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053633" } ] }, { "name": "kallikrein-1 N-glycosylated 39 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-165 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G63065KG. Example: UniProtKB:P06870-1, Asn-165, MOD:00160~GNO:G63065KG. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053634", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053634" } ] }, { "name": "kallikrein-1 N-glycosylated 40 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-165 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G72221XM. Example: UniProtKB:P06870-1, Asn-165, MOD:00160~GNO:G72221XM. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053635", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053635" } ] }, { "name": "kallikrein-1 N-glycosylated 41 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-165 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G85542KD. Example: UniProtKB:P06870-1, Asn-165, MOD:00160~GNO:G85542KD. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053636", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053636" } ] }, { "name": "kallikrein-1 N-glycosylated 42 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-165 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G88417ED. Example: UniProtKB:P06870-1, Asn-165, MOD:00160~GNO:G88417ED. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053637", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053637" } ] }, { "name": "kallikrein-1 N-glycosylated 43 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-165 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G88461FF. Example: UniProtKB:P06870-1, Asn-165, MOD:00160~GNO:G88461FF. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053638", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053638" } ] }, { "name": "kallikrein-1 N-glycosylated 44 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-165 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G88948CY. Example: UniProtKB:P06870-1, Asn-165, MOD:00160~GNO:G88948CY. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053639", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053639" } ] }, { "name": "kallikrein-1 N-glycosylated 45 (human)", "definition": "A kallikrein-1 (human) that has been N-glycosylated at the residue equivalent to Asn-165 of the amino acid sequence represented by UniProtKB:P06870-1, in which the glycan structure is represented by GlyTouCan:G96063MG. Example: UniProtKB:P06870-1, Asn-165, MOD:00160~GNO:G96063MG. [PRO:DNx, PMID:8416919]", "evidence": [ { "id": "PR:000053640", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000053640" } ] } ], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 108, "end_pos": 110, "annotation": "n_glycosylation_sequon" }, { "start_pos": 165, "end_pos": 167, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "The O-linked polysaccharides on Ser-93, Ser-104 and Ser-167 are probably the mucin type linked to GalNAc. In PubMed:3163150, GalNAc was detected with the corresponding peptides but not located.", "evidence": [ { "database": "UniProtKB", "id": "P06870", "url": "https://www.uniprot.org/uniprot/P06870" }, { "database": "PubMed", "id": "15651049", "url": "https://glygen.org/publication/PubMed/15651049" }, { "database": "PubMed", "id": "3163150", "url": "https://glygen.org/publication/PubMed/3163150" } ] } ], "interactions": [], "reactions": [ { "id": "R-HSA-381466", "name": "Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS", "equation": "", "summary": "Prostate specific Antigen (PSA, KLK3) cleaves IGFBP-3 in the IGF:IGFBP-3:ALS Complex between amino acids 186 and 187. Other cleavage sites were observed but not reproducibly. These may have been caused by impurities in the PSA preparation.", "cellular_location": "extracellular region", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07288-1", "P06870-1", "P20151-1", "Q9UKR3-1" ], "evidence": [ { "id": "R-HSA-381466", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381466" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "P06870", "gene_name": "KLK1", "activity": [ { "ec_number": "3.4.21.35", "activity": "Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.", "evidence": [ { "id": "P06870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06870" } ] }, { "ec_number": "3.4.21.35", "activity": "", "evidence": [ { "id": "P06870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06870" } ] } ] }, { "uniprot_ac": "P07288", "gene_name": "KLK3", "activity": [ { "ec_number": "3.4.21.77", "activity": "Preferential cleavage: -Tyr-|-Xaa-.", "evidence": [ { "id": "P07288", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07288" } ] }, { "ec_number": "3.4.21.77", "activity": "", "evidence": [ { "id": "P07288", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07288" } ] } ] }, { "uniprot_ac": "P20151", "gene_name": "KLK2", "activity": [ { "ec_number": "3.4.21.35", "activity": "Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.", "evidence": [ { "id": "P20151", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20151" } ] }, { "ec_number": "3.4.21.35", "activity": "", "evidence": [ { "id": "P20151", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20151" } ] } ] }, { "uniprot_ac": "Q9UKR3", "gene_name": "KLK13", "activity": [ { "ec_number": "3.4.21.-", "activity": "", "evidence": [ { "id": "Q9UKR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UKR3" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 102, 108, 165 ], "o_linked_sites": [ 93, 104, 167 ], "snv_sites": [ 87, 109, 110, 165, 167, 186 ], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 }, { "start_pos": 108, "end_pos": 110 }, { "start_pos": 165, "end_pos": 167 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 79 }, { "field": "total_sites", "count": 7 }, { "field": "n_linked_glycans", "count": 28 }, { "field": "n_linked_glycan_sites", "count": 7 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 3 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 3 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 3 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 73 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_glycans", "count": 28 }, { "field": "n_linked_glycan_sites", "count": 4 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 9 }, { "field": "total_sites", "count": 6 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 81 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }