{ "uniprot_canonical_ac": "P06730-1", "uniprot_ac": "P06730", "uniprot_id": "IF4E_HUMAN", "mass": { "chemical_mass": 25097.0, "monoisotopic_mass": 25097.0 }, "refseq": { "ac": "NP_001317946", "name": "eukaryotic translation initiation factor 4E isoform 4", "summary": "The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317946" }, "gene_names": [ { "name": "EIF4E", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P06730", "id": "P06730" }, { "name": "AUTS19; CBP; eIF-4E; EIF4E1; EIF4EL1; EIF4F", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317946", "id": "NP_001317946" }, { "name": "EIF4EL1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P06730", "id": "P06730" }, { "name": "EIF4E", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317946", "id": "NP_001317946" }, { "name": "EIF4F", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P06730", "id": "P06730" } ], "protein_names": [ { "name": "Eukaryotic translation initiation factor 4E", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P06730" }, { "name": "eIF-4E", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P06730" }, { "name": "eIF-4F 25 kDa subunit", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P06730" }, { "name": "eIF4E", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P06730" }, { "name": "eukaryotic translation initiation factor 4E isoform 4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317946", "id": "NP_001317946" }, { "name": "mRNA cap-binding protein; eIF-4F 25 kDa subunit; eukaryotic translation initiation factor 4E-like 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317946", "id": "NP_001317946" }, { "name": "mRNA cap-binding protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P06730" } ], "function": [ { "annotation": "Acts in the cytoplasm to initiate and regulate protein synthesis and is required in the nucleus for export of a subset of mRNAs from the nucleus to the cytoplasm which promotes processes such as RNA capping, processing and splicing (PubMed:11606200, PubMed:24335285, PubMed:29987188, PubMed:22684010, PubMed:22578813). Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity). This protein recognizes and binds the 7-methylguanosine (m7G)-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:16271312, PubMed:22578813). Together with EIF4G1, antagonizes the scanning promoted by EIF1-EIF4G1 and is required for TISU translation, a process where the TISU element recognition makes scanning unnecessary (PubMed:29987188). In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (PubMed:24335285). Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap (By similarity). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (PubMed:24335285). May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). As well as its roles in translation, also involved in mRNA nucleocytoplasmic transport (By similarity). Its role in mRNA export from the nucleus to the cytoplasm relies on its ability to bind the m7G cap of RNAs and on the presence of the 50-nucleotide EIF4E sensitivity element (4ESE) in the 3'UTR of sensitive transcripts (By similarity). Interaction with the 4ESE is mediated by LRPPRC which binds simultaneously to both EIF4E and the 4ESE, thereby acting as a platform for assembly for the RNA export complex (By similarity). EIF4E-dependent mRNA export is independent of ongoing protein or RNA synthesis and is also NFX1-independent but is XPO1-dependent with LRPPRC interacting with XPO1 to form an EIF4E-dependent mRNA export complex (By similarity). Alters the composition of the cytoplasmic face of the nuclear pore to promote RNA export by reducing RANBP2 expression, relocalizing nucleoporin NUP214 and increasing expression of RANBP1 and RNA export factors DDX19 and GLE1 (By similarity). Promotes the nuclear export of cyclin CCND1 mRNA (By similarity). Promotes the nuclear export of NOS2/iNOS mRNA (PubMed:23471078). Promotes the nuclear export of MDM2 mRNA (PubMed:22684010). Promotes the export of additional mRNAs, including others involved in the cell cycle (By similarity). In the nucleus, binds to capped splice factor-encoding mRNAs and stimulates their nuclear export to enhance splice factor production by increasing their cytoplasmic availability to the translation machinery (By similarity). May also regulate splicing through interaction with the spliceosome in an RNA and m7G cap-dependent manner (By similarity). Also binds to some pre-mRNAs and may play a role in their recruitment to the spliceosome (By similarity). Promotes steady-state capping of a subset of coding and non-coding RNAs by mediating nuclear export of capping machinery mRNAs including RNMT, RNGTT and RAMAC to enhance their translation (By similarity). Stimulates mRNA 3'-end processing by promoting the expression of several core cleavage complex factors required for mRNA cleavage and polyadenylation, and may also have a direct effect through its interaction with the CPSF3 cleavage enzyme (By similarity). Rescues cells from apoptosis by promoting activation of serine/threonine-protein kinase AKT1 through mRNA export of NBS1 which potentiates AKT1 phosphorylation and also through mRNA export of AKT1 effectors, allowing for increased production of these proteins (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730#function" }, { "database": "PubMed", "id": "16271312", "url": "https://glygen.org/publication/PubMed/16271312" }, { "database": "PubMed", "id": "22578813", "url": "https://glygen.org/publication/PubMed/22578813" }, { "database": "UniProtKB", "id": "P63073", "url": "https://www.uniprot.org/uniprot/P63073#function" }, { "database": "PubMed", "id": "24335285", "url": "https://glygen.org/publication/PubMed/24335285" }, { "database": "UniProtKB", "id": "P63074", "url": "https://www.uniprot.org/uniprot/P63074#function" }, { "database": "PubMed", "id": "22684010", "url": "https://glygen.org/publication/PubMed/22684010" }, { "database": "PubMed", "id": "29987188", "url": "https://glygen.org/publication/PubMed/29987188" }, { "database": "PubMed", "id": "23471078", "url": "https://glygen.org/publication/PubMed/23471078" }, { "database": "PubMed", "id": "11606200", "url": "https://glygen.org/publication/PubMed/11606200" } ] }, { "annotation": "Crystallographic and mass spectrometric characterisation of eIF4E with N7-alkylated cap derivatives. Review article", "evidence": [ { "database": "RefSeq", "id": "NP_001317946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317946" }, { "database": "PubMed", "id": "17631896", "url": "https://glygen.org/publication/PubMed/17631896" } ] }, { "annotation": "Genetic Evidence Supporting a Causal Association Between mTOR-Dependent EIF-4E Circulating Protein Level and Osteoporosis.", "evidence": [ { "database": "RefSeq", "id": "NP_001317946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317946" }, { "database": "PubMed", "id": "37728694", "url": "https://glygen.org/publication/PubMed/37728694" } ] }, { "annotation": "Human eIF4E promotes mRNA restructuring by stimulating eIF4A helicase activity.", "evidence": [ { "database": "RefSeq", "id": "NP_001317946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317946" }, { "database": "PubMed", "id": "23901100", "url": "https://glygen.org/publication/PubMed/23901100" } ] }, { "annotation": "Neural precursors are transcriptionally primed to generate neurons, but an eIF4E/4E-T complex sequesters and represses translation of proneurogenic proteins to determine appropriate neurogenesis.", "evidence": [ { "database": "RefSeq", "id": "NP_001317946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317946" }, { "database": "PubMed", "id": "25456498", "url": "https://glygen.org/publication/PubMed/25456498" } ] }, { "annotation": "The crystal structures of the full-length human eukaryotic initiation factor (eIF) 4E complexed with two mRNA cap analogues", "evidence": [ { "database": "RefSeq", "id": "NP_001317946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317946" }, { "database": "PubMed", "id": "11879179", "url": "https://glygen.org/publication/PubMed/11879179" } ] }, { "annotation": "The eukaryotic translation initiation factor eIF4E unexpectedly acts in splicing thereby coupling mRNA processing with translation: eIF4E induces widescale splicing reprogramming providing system-wide connectivity between splicing, nuclear mRNA export and translation.", "evidence": [ { "database": "RefSeq", "id": "NP_001317946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317946" }, { "database": "PubMed", "id": "37926700", "url": "https://glygen.org/publication/PubMed/37926700" } ] }, { "annotation": "The findings suggest further that eIF4E sumoylation is a new fundamental regulatory mechanism of protein synthesis and might be important in promoting human cancers.", "evidence": [ { "database": "RefSeq", "id": "NP_001317946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317946" }, { "database": "PubMed", "id": "20224576", "url": "https://glygen.org/publication/PubMed/20224576" } ] }, { "annotation": "The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].", "evidence": [ { "database": "RefSeq", "id": "NP_001317946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317946" } ] } ], "disease": [ { "disease_id": "MONDO:0014041", "recommended_name": { "id": "MONDO:0014041", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014041", "name": "autism, susceptibility to, 19", "description": "" }, "synonyms": [ { "id": "MONDO:0014041", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014041", "name": "autism, susceptibility to, 19", "description": "" }, { "id": "MONDO:0014041", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014041", "name": "autism, susceptibility to, type 19", "description": "" }, { "id": "MONDO:0014041", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014041", "name": "AUTS19", "description": "" }, { "id": "MONDO:0014041", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014041", "name": "susceptibility to autism 19", "description": "" }, { "id": "MIM:615091", "resource": "MIM", "url": "https://www.omim.org/entry/615091", "name": "Autism 19", "description": "Autism 19" } ], "evidence": [ { "id": "615091", "database": "MIM", "url": "https://www.omim.org/entry/615091" } ] } ], "snv": [ { "evidence": [ { "id": "rs770337295", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs770337295" }, { "id": "rs770337295", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs770337295" }, { "id": "rs770337295", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs770337295" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 177, "end_pos": 177, "sequence_org": "T", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->A).", "chr_id": "4", "chr_pos": "98884932", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T177", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs769814766", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs769814766" }, { "id": "rs769814766", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs769814766" }, { "id": "rs769814766", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs769814766" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 79, "end_pos": 79, "sequence_org": "I", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NHI->NHT).", "chr_id": "4", "chr_pos": "98887938", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I79", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [ { "start_pos": 102, "end_pos": 102, "sequence_org": "W", "sequence_mut": "L", "comment": "Decrease in mRNA cap binding; when associated with A-105.", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "PubMed", "id": "1672854", "url": "https://glygen.org/publication/PubMed/1672854" } ] }, { "start_pos": 103, "end_pos": 103, "sequence_org": "E", "sequence_mut": "A", "comment": "No effect.", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "PubMed", "id": "1672854", "url": "https://glygen.org/publication/PubMed/1672854" } ] }, { "start_pos": 104, "end_pos": 104, "sequence_org": "D", "sequence_mut": "A", "comment": "No effect.", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "PubMed", "id": "1672854", "url": "https://glygen.org/publication/PubMed/1672854" } ] }, { "start_pos": 105, "end_pos": 105, "sequence_org": "E", "sequence_mut": "A", "comment": "Decrease in mRNA cap binding; when associated with L-102.", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "PubMed", "id": "1672854", "url": "https://glygen.org/publication/PubMed/1672854" } ] }, { "start_pos": 119, "end_pos": 119, "sequence_org": "K", "sequence_mut": "A", "comment": "Higher affinity for EIF4G1.", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "PubMed", "id": "17036047", "url": "https://glygen.org/publication/PubMed/17036047" } ] }, { "start_pos": 209, "end_pos": 209, "sequence_org": "S", "sequence_mut": "A", "comment": "Abolishes resistance to cellular stress and DNA-damaging agents. Does not affect ability to rescue growth of yeast lacking a functional EIF4E/CDC33 gene.", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "PubMed", "id": "25923732", "url": "https://glygen.org/publication/PubMed/25923732" }, { "database": "PubMed", "id": "11606200", "url": "https://glygen.org/publication/PubMed/11606200" } ] }, { "start_pos": 209, "end_pos": 209, "sequence_org": "S", "sequence_mut": "D", "comment": "Phosphomimetic mutant; confers resistance to cellular stress and DNA-damaging agents. Does not affect ability to rescue growth of yeast lacking a functional EIF4E/CDC33 gene.", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "PubMed", "id": "25923732", "url": "https://glygen.org/publication/PubMed/25923732" }, { "database": "PubMed", "id": "11606200", "url": "https://glygen.org/publication/PubMed/11606200" } ] }, { "start_pos": 53, "end_pos": 53, "sequence_org": "S", "sequence_mut": "A", "comment": "Does not affect ability to rescue growth of yeast lacking a functional EIF4E/CDC33 gene.", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "PubMed", "id": "11606200", "url": "https://glygen.org/publication/PubMed/11606200" } ] }, { "start_pos": 53, "end_pos": 53, "sequence_org": "S", "sequence_mut": "A", "comment": "No effect on phosphorylation level nor incorporation into eIF4F complex.", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "PubMed", "id": "8505316", "url": "https://glygen.org/publication/PubMed/8505316" }, { "database": "PubMed", "id": "7590282", "url": "https://glygen.org/publication/PubMed/7590282" } ] }, { "start_pos": 53, "end_pos": 53, "sequence_org": "S", "sequence_mut": "D", "comment": "No effect on phosphorylation level nor incorporation into eIF4F complex.", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "PubMed", "id": "8505316", "url": "https://glygen.org/publication/PubMed/8505316" }, { "database": "PubMed", "id": "7590282", "url": "https://glygen.org/publication/PubMed/7590282" } ] }, { "start_pos": 56, "end_pos": 56, "sequence_org": "W", "sequence_mut": "A", "comment": "Impairs mRNA nuclear export. Reduces affinity for ribavirin.", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "PubMed", "id": "15601771", "url": "https://glygen.org/publication/PubMed/15601771" }, { "database": "PubMed", "id": "22684010", "url": "https://glygen.org/publication/PubMed/22684010" } ] }, { "start_pos": 73, "end_pos": 73, "sequence_org": "W", "sequence_mut": "A", "comment": "Abolishes binding to EIF4EBP1. Impairs interaction with DDX3X. Does not impair mRNA nuclear export. Does not affect affinity for ribavirin.", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "PubMed", "id": "22578813", "url": "https://glygen.org/publication/PubMed/22578813" }, { "database": "PubMed", "id": "17667941", "url": "https://glygen.org/publication/PubMed/17667941" }, { "database": "PubMed", "id": "15601771", "url": "https://glygen.org/publication/PubMed/15601771" }, { "database": "PubMed", "id": "22684010", "url": "https://glygen.org/publication/PubMed/22684010" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "77.34", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000151247", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000151247" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "87.17", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000151247", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000151247" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "79.61", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000151247", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000151247" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "59.95", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000151247", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000151247" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "94.91", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000151247", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000151247" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "97.21", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000151247", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000151247" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "57.41", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000151247", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000151247" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "87.95", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000151247", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000151247" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "92.35", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000151247", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000151247" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "59.79", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000151247", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000151247" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "90.58", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000151247", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000151247" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "89.48", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000151247", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000151247" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "91.05", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000151247", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000151247" } ] } ], "expression_disease": [ { "significant": "No", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P06730", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06730" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P06730", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06730" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "P06730", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06730" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "P06730", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06730" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "P06730", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06730" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "P06730", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06730" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P06730", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06730" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "P06730", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06730" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "P06730", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06730" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Uterine cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:363", "evidence": [ { "database": "BioXpress", "id": "P06730", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06730" } ], "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Esophageal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:5041", "evidence": [ { "database": "BioXpress", "id": "P06730", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06730" } ], "disease": [ { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Aerodigestive tract cancer, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Escc, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "gastric cardia adenocarcinoma, susceptibility to", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Colorectal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:9256", "evidence": [ { "database": "BioXpress", "id": "P06730", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06730" } ], "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "common_name": "Human" } ], "gene": [ { "name": "EIF4E", "url": "https://www.uniprot.org/uniprot/P06730", "locus": { "chromosome": "4", "start_pos": 98879276, "end_pos": 98929133, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000151247", "url": "https://www.ensembl.org/id/ENSG00000151247" } ] } } ], "crossref": [ { "id": "ENSG00000151247", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000151247", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "CHEMBL4848", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL4848", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "EIF4E", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=EIF4E", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "1977", "url": "https://www.ncbi.nlm.nih.gov/gene/1977", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "3287", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3287", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "D6RBW1", "url": "https://www.ebi.ac.uk/intact/interactors/id:D6RBW1*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "P06730", "url": "https://www.ebi.ac.uk/intact/interactors/id:P06730*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001040", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001040", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023398", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023398", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:1977", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:1977", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "133440", "url": "http://www.omim.org/entry/133440", "database": "MIM", "categories": [ "Other" ] }, { "id": "615091", "url": "http://www.omim.org/entry/615091", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_P06730", "url": "https://www.nextprot.org/entry/NX_P06730", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "P06730", "url": "https://oglcnac.org/atlas/detail/P06730", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "P06730", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P06730", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "FWFDTPS", "url": "https://omabrowser.org/oma/group/FWFDTPS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "180043at2759", "url": "http://www.orthodb.org/?query=180043at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11960", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11960", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11960:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11960:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "1IPB", "url": "https://www.rcsb.org/structure/1IPB", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1IPC", "url": "https://www.rcsb.org/structure/1IPC", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1WKW", "url": "https://www.rcsb.org/structure/1WKW", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2GPQ", "url": "https://www.rcsb.org/structure/2GPQ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2V8W", "url": "https://www.rcsb.org/structure/2V8W", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2V8X", "url": "https://www.rcsb.org/structure/2V8X", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2V8Y", "url": "https://www.rcsb.org/structure/2V8Y", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2W97", "url": "https://www.rcsb.org/structure/2W97", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3AM7", "url": "https://www.rcsb.org/structure/3AM7", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3TF2", "url": "https://www.rcsb.org/structure/3TF2", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3U7X", "url": "https://www.rcsb.org/structure/3U7X", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4AZA", "url": "https://www.rcsb.org/structure/4AZA", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4BEA", "url": "https://www.rcsb.org/structure/4BEA", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4DT6", "url": "https://www.rcsb.org/structure/4DT6", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4DUM", "url": "https://www.rcsb.org/structure/4DUM", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4TPW", "url": "https://www.rcsb.org/structure/4TPW", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4TQB", "url": "https://www.rcsb.org/structure/4TQB", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4TQC", "url": "https://www.rcsb.org/structure/4TQC", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4UED", "url": "https://www.rcsb.org/structure/4UED", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5EHC", "url": "https://www.rcsb.org/structure/5EHC", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5EI3", "url": "https://www.rcsb.org/structure/5EI3", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5EIR", "url": "https://www.rcsb.org/structure/5EIR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5EKV", "url": "https://www.rcsb.org/structure/5EKV", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5GW6", "url": "https://www.rcsb.org/structure/5GW6", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5T46", "url": "https://www.rcsb.org/structure/5T46", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5ZJY", "url": "https://www.rcsb.org/structure/5ZJY", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5ZJZ", "url": "https://www.rcsb.org/structure/5ZJZ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5ZK5", "url": "https://www.rcsb.org/structure/5ZK5", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5ZK7", "url": "https://www.rcsb.org/structure/5ZK7", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5ZK9", "url": "https://www.rcsb.org/structure/5ZK9", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5ZML", "url": "https://www.rcsb.org/structure/5ZML", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7D6Y", "url": "https://www.rcsb.org/structure/7D6Y", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7D8B", "url": "https://www.rcsb.org/structure/7D8B", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7EZW", "url": "https://www.rcsb.org/structure/7EZW", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7F07", "url": "https://www.rcsb.org/structure/7F07", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7MEU", "url": "https://www.rcsb.org/structure/7MEU", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7XTP", "url": "https://www.rcsb.org/structure/7XTP", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8SX4", "url": "https://www.rcsb.org/structure/8SX4", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF01652", "url": "http://pfam.xfam.org/family/PF01652", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P06730", "url": "https://pharos.nih.gov/targets/P06730", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_P06730", "url": "http://purl.obolibrary.org/obo/PR_P06730", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156827", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-159227", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159227", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-159230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159230", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-159231", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159231", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-166208", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166208", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-429947", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-429947", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-72649", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72649", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-72662", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72662", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-72702", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72702", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72706", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9820841", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9820841", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9820865", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9820865", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001317946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317946", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "D6RBW1", "url": "https://www.uniprot.org/uniprot/D6RBW1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RBW1-1", "url": "https://www.uniprot.org/uniprot/D6RBW1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RFJ3", "url": "https://www.uniprot.org/uniprot/D6RFJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RFJ3-1", "url": "https://www.uniprot.org/uniprot/D6RFJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y8J7", "url": "https://www.uniprot.org/uniprot/H0Y8J7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y8J7-1", "url": "https://www.uniprot.org/uniprot/H0Y8J7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P06730-1", "url": "https://www.uniprot.org/uniprot/P06730-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P06730-2", "url": "https://www.uniprot.org/uniprot/P06730-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P06730-3", "url": "https://www.uniprot.org/uniprot/P06730-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV", "length": 217, "header": "sp|P06730-1|IF4E_HUMAN Isoform 1 of Eukaryotic translation initiation factor 4E OS=Homo sapiens OX=9606 GN=EIF4E PE=1 SV=2 CANONICAL=P06730-1" }, "isoforms": [ { "isoform_ac": "D6RBW1-1", "url": "", "sequence": { "sequence": "MKKKQNKKERKKMRAEDGENDAIKKQAESLRESQETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV", "length": 245, "header": "tr|D6RBW1-1|IF4E_HUMAN Computationally mapped isoform of Eukaryotic translation initiation factor 4E OS=Homo sapiens OX=9606 GN=EIF4E PE=1 SV=1 CANONICAL=P06730-1" }, "locus": { "chromosome": "4", "start_pos": 98909779, "end_pos": 98881031, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000504432.5", "url": "https://www.ensembl.org/id/ENST00000504432.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000423977.1", "url": "https://www.ensembl.org/id/ENSP00000423977.1" } ] } }, { "isoform_ac": "D6RFJ3-1", "url": "", "sequence": { "sequence": "MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNR", "length": 42, "header": "tr|D6RFJ3-1|D6RFJ3_HUMAN Computationally mapped isoform of Eukaryotic translation initiation factor 4E OS=Homo sapiens OX=9606 GN=EIF4E PE=1 SV=1 CANONICAL=P06730-1" }, "locus": { "chromosome": "4", "start_pos": 98929112, "end_pos": 98887167, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000515638.5", "url": "https://www.ensembl.org/id/ENST00000515638.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000426602.1", "url": "https://www.ensembl.org/id/ENSP00000426602.1" } ] } }, { "isoform_ac": "H0Y8J7-1", "url": "", "sequence": { "sequence": "XEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETEGIQGKVRTSSKDSDWLSVPRRHSY", "length": 155, "header": "tr|H0Y8J7-1|H0Y8J7_HUMAN Computationally mapped isoform of Eukaryotic translation initiation factor 4E OS=Homo sapiens OX=9606 GN=EIF4E PE=1 SV=1 CANONICAL=P06730-1" }, "locus": { "chromosome": "4", "start_pos": 98929101, "end_pos": 98881066, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000511644.5", "url": "https://www.ensembl.org/id/ENST00000511644.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000421287.1", "url": "https://www.ensembl.org/id/ENSP00000421287.1" } ] } }, { "isoform_ac": "P06730-1", "url": "", "sequence": { "sequence": "MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV", "length": 217, "header": "sp|P06730-1|IF4E_HUMAN Isoform 1 of Eukaryotic translation initiation factor 4E OS=Homo sapiens OX=9606 GN=EIF4E PE=1 SV=2 CANONICAL=P06730-1" }, "locus": { "chromosome": "4", "start_pos": 98929112, "end_pos": 98881031, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000450253.7", "url": "https://www.ensembl.org/id/ENST00000450253.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000389624.2", "url": "https://www.ensembl.org/id/ENSP00000389624.2" } ] } }, { "isoform_ac": "P06730-2", "url": "", "sequence": { "sequence": "MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETRWDLAMLPRLVSNFWPQVILPLQPPKVLELQLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV", "length": 248, "header": "sp|P06730-2|IF4E_HUMAN Isoform 2 of Eukaryotic translation initiation factor 4E OS=Homo sapiens OX=9606 GN=EIF4E PE=1 SV=2 CANONICAL=P06730-1" }, "locus": { "chromosome": "4", "start_pos": 98929112, "end_pos": 98881031, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000505992.1", "url": "https://www.ensembl.org/id/ENST00000505992.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000425561.1", "url": "https://www.ensembl.org/id/ENSP00000425561.1" } ] } }, { "isoform_ac": "P06730-3", "url": "", "sequence": { "sequence": "MLDLTSRGQVGTSRRMAEAACSAHFLETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV", "length": 237, "header": "sp|P06730-3|IF4E_HUMAN Isoform 3 of Eukaryotic translation initiation factor 4E OS=Homo sapiens OX=9606 GN=EIF4E PE=1 SV=2 CANONICAL=P06730-1" }, "locus": { "chromosome": "4", "start_pos": 98928972, "end_pos": 98881031, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000280892.10", "url": "https://www.ensembl.org/id/ENST00000280892.10" }, { "database": "Ensembl Peptide", "id": "ENSP00000280892.6", "url": "https://www.ensembl.org/id/ENSP00000280892.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 168, "start_aa": "Thr", "end_pos": 168, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr168", "evidence": [ { "id": "P06730", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P06730" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "30677218", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30677218" }, { "id": "P06730", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P06730" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 177, "start_aa": "Thr", "end_pos": 177, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr177", "evidence": [ { "id": "P06730", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P06730" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "30677218", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30677218" }, { "id": "P06730", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P06730" } ] } ], "phosphorylation": [ { "start_pos": 207, "end_pos": 207, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" }, { "database": "PubMed", "id": "15248766", "url": "https://glygen.org/publication/PubMed/15248766" } ], "site_lbl": "Ser207" }, { "start_pos": 209, "end_pos": 209, "kinase_uniprot_canonical_ac": "O00443-1", "kinase_gene_name": "PIK3C2A", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" }, { "database": "PubMed", "id": "7782349", "url": "https://glygen.org/publication/PubMed/7782349" } ], "site_lbl": "Ser209" }, { "start_pos": 209, "end_pos": 209, "kinase_uniprot_canonical_ac": "P05129-1", "kinase_gene_name": "PRKCG", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" }, { "database": "PubMed", "id": "8662663", "url": "https://glygen.org/publication/PubMed/8662663" } ], "site_lbl": "Ser209" }, { "start_pos": 209, "end_pos": 209, "kinase_uniprot_canonical_ac": "P05771-1", "kinase_gene_name": "PRKCB", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" }, { "database": "PubMed", "id": "8662663", "url": "https://glygen.org/publication/PubMed/8662663" } ], "site_lbl": "Ser209" }, { "start_pos": 209, "end_pos": 209, "kinase_uniprot_canonical_ac": "P17252-1", "kinase_gene_name": "PRKCA", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" }, { "database": "PubMed", "id": "8662663", "url": "https://glygen.org/publication/PubMed/8662663" } ], "site_lbl": "Ser209" }, { "start_pos": 209, "end_pos": 209, "kinase_uniprot_canonical_ac": "Q9BUB5-1", "kinase_gene_name": "MKNK1", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" }, { "database": "PubMed", "id": "9155017", "url": "https://glygen.org/publication/PubMed/9155017" }, { "database": "PubMed", "id": "9878069", "url": "https://glygen.org/publication/PubMed/9878069" }, { "database": "PubMed", "id": "20722422", "url": "https://glygen.org/publication/PubMed/20722422" }, { "database": "PubMed", "id": "17724079", "url": "https://glygen.org/publication/PubMed/17724079" } ], "site_lbl": "Ser209" }, { "start_pos": 209, "end_pos": 209, "kinase_uniprot_canonical_ac": "Q9HBH9-1", "kinase_gene_name": "MKNK2", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" }, { "database": "PubMed", "id": "12897141", "url": "https://glygen.org/publication/PubMed/12897141" }, { "database": "PubMed", "id": "9155017", "url": "https://glygen.org/publication/PubMed/9155017" }, { "database": "PubMed", "id": "11154262", "url": "https://glygen.org/publication/PubMed/11154262" }, { "database": "PubMed", "id": "11463832", "url": "https://glygen.org/publication/PubMed/11463832" }, { "database": "PubMed", "id": "20823271", "url": "https://glygen.org/publication/PubMed/20823271" }, { "database": "PubMed", "id": "20927323", "url": "https://glygen.org/publication/PubMed/20927323" }, { "database": "PubMed", "id": "20722422", "url": "https://glygen.org/publication/PubMed/20722422" }, { "database": "PubMed", "id": "17724079", "url": "https://glygen.org/publication/PubMed/17724079" } ], "site_lbl": "Ser209" }, { "start_pos": 209, "end_pos": 209, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PKC and MKNK2", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "IntAct", "id": "P06730", "url": "https://www.ebi.ac.uk/intact/interactors/id:P06730*" }, { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" }, { "database": "PubMed", "id": "20927323", "url": "https://glygen.org/publication/PubMed/20927323" }, { "database": "PubMed", "id": "12890645", "url": "https://glygen.org/publication/PubMed/12890645" }, { "database": "phospho.ELM", "id": "P06730", "url": "http://phospho.elm.eu.org/byAccession/P06730.html" }, { "database": "PubMed", "id": "11723111", "url": "https://glygen.org/publication/PubMed/11723111" }, { "database": "PubMed", "id": "7782323", "url": "https://glygen.org/publication/PubMed/7782323" }, { "database": "PubMed", "id": "11463832", "url": "https://glygen.org/publication/PubMed/11463832" }, { "database": "PubMed", "id": "10022874", "url": "https://glygen.org/publication/PubMed/10022874" }, { "database": "PubMed", "id": "10891393", "url": "https://glygen.org/publication/PubMed/10891393" }, { "database": "PubMed", "id": "11112322", "url": "https://glygen.org/publication/PubMed/11112322" }, { "database": "PubMed", "id": "11154262", "url": "https://glygen.org/publication/PubMed/11154262" }, { "database": "PubMed", "id": "11368785", "url": "https://glygen.org/publication/PubMed/11368785" }, { "database": "PubMed", "id": "11606200", "url": "https://glygen.org/publication/PubMed/11606200" }, { "database": "PubMed", "id": "12554876", "url": "https://glygen.org/publication/PubMed/12554876" }, { "database": "PubMed", "id": "12691746", "url": "https://glygen.org/publication/PubMed/12691746" }, { "database": "PubMed", "id": "15122903", "url": "https://glygen.org/publication/PubMed/15122903" }, { "database": "PubMed", "id": "15248766", "url": "https://glygen.org/publication/PubMed/15248766" }, { "database": "PubMed", "id": "15574771", "url": "https://glygen.org/publication/PubMed/15574771" }, { "database": "PubMed", "id": "16540463", "url": "https://glygen.org/publication/PubMed/16540463" }, { "database": "PubMed", "id": "16982703", "url": "https://glygen.org/publication/PubMed/16982703" }, { "database": "PubMed", "id": "17724079", "url": "https://glygen.org/publication/PubMed/17724079" }, { "database": "PubMed", "id": "18365020", "url": "https://glygen.org/publication/PubMed/18365020" }, { "database": "PubMed", "id": "19714237", "url": "https://glygen.org/publication/PubMed/19714237" }, { "database": "PubMed", "id": "19934253", "url": "https://glygen.org/publication/PubMed/19934253" }, { "database": "PubMed", "id": "20664001", "url": "https://glygen.org/publication/PubMed/20664001" }, { "database": "PubMed", "id": "20686366", "url": "https://glygen.org/publication/PubMed/20686366" }, { "database": "PubMed", "id": "20823271", "url": "https://glygen.org/publication/PubMed/20823271" }, { "database": "PubMed", "id": "21233335", "url": "https://glygen.org/publication/PubMed/21233335" }, { "database": "PubMed", "id": "21635931", "url": "https://glygen.org/publication/PubMed/21635931" }, { "database": "PubMed", "id": "21837706", "url": "https://glygen.org/publication/PubMed/21837706" }, { "database": "PubMed", "id": "21949767", "url": "https://glygen.org/publication/PubMed/21949767" }, { "database": "PubMed", "id": "22392765", "url": "https://glygen.org/publication/PubMed/22392765" }, { "database": "PubMed", "id": "23824493", "url": "https://glygen.org/publication/PubMed/23824493" }, { "database": "PubMed", "id": "24504069", "url": "https://glygen.org/publication/PubMed/24504069" }, { "database": "PubMed", "id": "24551240", "url": "https://glygen.org/publication/PubMed/24551240" }, { "database": "PubMed", "id": "25193863", "url": "https://glygen.org/publication/PubMed/25193863" }, { "database": "PubMed", "id": "25277198", "url": "https://glygen.org/publication/PubMed/25277198" }, { "database": "PubMed", "id": "25403230", "url": "https://glygen.org/publication/PubMed/25403230" }, { "database": "PubMed", "id": "25535978", "url": "https://glygen.org/publication/PubMed/25535978" }, { "database": "PubMed", "id": "25561727", "url": "https://glygen.org/publication/PubMed/25561727" }, { "database": "PubMed", "id": "25915158", "url": "https://glygen.org/publication/PubMed/25915158" }, { "database": "PubMed", "id": "26041884", "url": "https://glygen.org/publication/PubMed/26041884" }, { "database": "PubMed", "id": "26097864", "url": "https://glygen.org/publication/PubMed/26097864" }, { "database": "PubMed", "id": "26268528", "url": "https://glygen.org/publication/PubMed/26268528" }, { "database": "PubMed", "id": "26317997", "url": "https://glygen.org/publication/PubMed/26317997" }, { "database": "PubMed", "id": "26861281", "url": "https://glygen.org/publication/PubMed/26861281" }, { "database": "PubMed", "id": "26882068", "url": "https://glygen.org/publication/PubMed/26882068" }, { "database": "PubMed", "id": "27237224", "url": "https://glygen.org/publication/PubMed/27237224" }, { "database": "PubMed", "id": "27462781", "url": "https://glygen.org/publication/PubMed/27462781" }, { "database": "PubMed", "id": "27926520", "url": "https://glygen.org/publication/PubMed/27926520" }, { "database": "PubMed", "id": "28386346", "url": "https://glygen.org/publication/PubMed/28386346" }, { "database": "PubMed", "id": "28745319", "url": "https://glygen.org/publication/PubMed/28745319" }, { "database": "PubMed", "id": "29269484", "url": "https://glygen.org/publication/PubMed/29269484" }, { "database": "PubMed", "id": "29581834", "url": "https://glygen.org/publication/PubMed/29581834" }, { "database": "PubMed", "id": "29683667", "url": "https://glygen.org/publication/PubMed/29683667" }, { "database": "PubMed", "id": "30388805", "url": "https://glygen.org/publication/PubMed/30388805" }, { "database": "PubMed", "id": "31113936", "url": "https://glygen.org/publication/PubMed/31113936" }, { "database": "PubMed", "id": "31118010", "url": "https://glygen.org/publication/PubMed/31118010" }, { "database": "PubMed", "id": "31258849", "url": "https://glygen.org/publication/PubMed/31258849" }, { "database": "PubMed", "id": "31398271", "url": "https://glygen.org/publication/PubMed/31398271" }, { "database": "PubMed", "id": "31903169", "url": "https://glygen.org/publication/PubMed/31903169" }, { "database": "PubMed", "id": "31949502", "url": "https://glygen.org/publication/PubMed/31949502" }, { "database": "PubMed", "id": "32535199", "url": "https://glygen.org/publication/PubMed/32535199" }, { "database": "PubMed", "id": "33014898", "url": "https://glygen.org/publication/PubMed/33014898" }, { "database": "PubMed", "id": "33092114", "url": "https://glygen.org/publication/PubMed/33092114" }, { "database": "PubMed", "id": "33116125", "url": "https://glygen.org/publication/PubMed/33116125" }, { "database": "PubMed", "id": "33439620", "url": "https://glygen.org/publication/PubMed/33439620" }, { "database": "PubMed", "id": "33971490", "url": "https://glygen.org/publication/PubMed/33971490" }, { "database": "PubMed", "id": "34012509", "url": "" }, { "database": "PubMed", "id": "35877722", "url": "" }, { "database": "PubMed", "id": "7782349", "url": "https://glygen.org/publication/PubMed/7782349" }, { "database": "PubMed", "id": "8662663", "url": "https://glygen.org/publication/PubMed/8662663" }, { "database": "PubMed", "id": "9642105", "url": "https://glygen.org/publication/PubMed/9642105" }, { "database": "PubMed", "id": "9878069", "url": "https://glygen.org/publication/PubMed/9878069" }, { "database": "PubMed", "id": "25923732", "url": "https://glygen.org/publication/PubMed/25923732" }, { "database": "PubMed", "id": "7665584", "url": "https://glygen.org/publication/PubMed/7665584" } ], "site_lbl": "Ser209" }, { "start_pos": 210, "end_pos": 210, "kinase_uniprot_canonical_ac": "O00443-1", "kinase_gene_name": "PIK3C2A", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" }, { "database": "PubMed", "id": "7782349", "url": "https://glygen.org/publication/PubMed/7782349" } ], "site_lbl": "Thr210" }, { "start_pos": 22, "end_pos": 22, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ], "site_lbl": "Thr22" }, { "start_pos": 53, "end_pos": 53, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" }, { "database": "PubMed", "id": "3112145", "url": "https://glygen.org/publication/PubMed/3112145" }, { "database": "phospho.ELM", "id": "P06730", "url": "http://phospho.elm.eu.org/byAccession/P06730.html" }, { "database": "PubMed", "id": "1587843", "url": "https://glygen.org/publication/PubMed/1587843" }, { "database": "PubMed", "id": "2122455", "url": "https://glygen.org/publication/PubMed/2122455" }, { "database": "PubMed", "id": "7590282", "url": "https://glygen.org/publication/PubMed/7590282" }, { "database": "PubMed", "id": "8505316", "url": "https://glygen.org/publication/PubMed/8505316" } ], "site_lbl": "Ser53" }, { "start_pos": 9, "end_pos": 9, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" }, { "database": "PubMed", "id": "19664995", "url": "https://glygen.org/publication/PubMed/19664995" } ], "site_lbl": "Thr9" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo.", "journal": "Molecular and cellular biology", "date": "1999", "authors": "Waskiewicz AJ, Johnson JC, Penn B, Mahalingam M, Kimball SR, Cooper JA", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "10022874", "url": "https://glygen.org/publication/PubMed/10022874" } ] }, { "title": "Ded1p, a DEAD-box protein required for translation initiation in Saccharomyces cerevisiae, is an RNA helicase.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Iost I, Dreyfus M, Linder P", "evidence": [ { "database": "Reactome", "id": "R-HSA-72702", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72702" } ], "reference": [ { "type": "PubMed", "id": "10364207", "url": "https://glygen.org/publication/PubMed/10364207" } ] }, { "title": "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.", "journal": "Nucleic acids research", "date": "2000", "authors": "Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT", "evidence": [ { "database": "Reactome", "id": "R-HSA-429947", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-429947" } ], "reference": [ { "type": "PubMed", "id": "10637334", "url": "https://glygen.org/publication/PubMed/10637334" } ] }, { "title": "Nuclear eukaryotic initiation factor 4E (eIF4E) colocalizes with splicing factors in speckles.", "journal": "J. Cell Biol.", "date": "2000", "authors": "Dostie J, Lejbkowicz F, Sonenberg N", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "10648556", "url": "https://glygen.org/publication/PubMed/10648556" } ] }, { "title": "Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI.", "journal": "The EMBO journal", "date": "2000-02-01", "authors": "Raught B, Gingras A C, Gygi S P, Imataka H, Morino S, Gradi A, Aebersold R, Sonenberg N", "evidence": [ { "database": "Reactome", "id": "R-HSA-166208", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166208" } ], "reference": [ { "type": "PubMed", "id": "10654941", "url": "https://glygen.org/publication/PubMed/10654941" } ] }, { "title": "The joining of ribosomal subunits in eukaryotes requires eIF5B.", "journal": "Nature", "date": "2000", "authors": "Pestova TV, Lomakin IB, Lee JH, Choi SK, Dever TE, Hellen CU", "evidence": [ { "database": "Reactome", "id": "R-HSA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72706" } ], "reference": [ { "type": "PubMed", "id": "10659855", "url": "https://glygen.org/publication/PubMed/10659855" } ] }, { "title": "A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E.", "journal": "EMBO J.", "date": "2000", "authors": "Dostie J, Ferraiuolo M, Pause A, Adam SA, Sonenberg N", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "10856257", "url": "https://glygen.org/publication/PubMed/10856257" } ] }, { "title": "Interaction between a poly(A)-specific ribonuclease and the 5' cap influences mRNA deadenylation rates in vitro.", "journal": "Molecular cell", "date": "2000", "authors": "Gao M, Fritz DT, Ford LP, Wilusz J", "evidence": [ { "database": "Reactome", "id": "R-HSA-429947", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-429947" } ], "reference": [ { "type": "PubMed", "id": "10882133", "url": "https://glygen.org/publication/PubMed/10882133" } ] }, { "title": "Phosphorylation of eIF-4E on Ser 209 in response to mitogenic and inflammatory stimuli is faithfully detected by specific antibodies.", "journal": "Molecular cell biology research communications : MCBRC", "date": "2000", "authors": "Tschopp C, Knauf U, Brauchle M, Zurini M, Ramage P, Glueck D, New L, Han J, Gram H", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "10891393", "url": "https://glygen.org/publication/PubMed/10891393" } ] }, { "title": "Purification and characterization of homogeneous initiation factor M2A from rabbit reticulocytes.", "journal": "The Journal of biological chemistry", "date": "1975", "authors": "Merrick WC, Kemper WM, Anderson WF", "evidence": [ { "database": "Reactome", "id": "R-HSA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72706" } ], "reference": [ { "type": "PubMed", "id": "1095581", "url": "https://glygen.org/publication/PubMed/1095581" } ] }, { "title": "The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans.", "journal": "Nature", "date": "2000", "authors": "Zhou Z, Luo MJ, Straesser K, Katahira J, Hurt E, Reed R", "evidence": [ { "database": "Reactome", "id": "R-HSA-159231", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159231" } ], "reference": [ { "type": "PubMed", "id": "11014198", "url": "https://glygen.org/publication/PubMed/11014198" } ] }, { "title": "A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo.", "journal": "Genes & development", "date": "2000", "authors": "Asano K, Clayton J, Shalev A, Hinnebusch AG", "evidence": [ { "database": "Reactome", "id": "R-HSA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72706" } ], "reference": [ { "type": "PubMed", "id": "11018020", "url": "https://glygen.org/publication/PubMed/11018020" } ] }, { "title": "A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: implications for filovirus budding.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2000", "authors": "Harty RN, Brown ME, Wang G, Huibregtse J, Hayes FP", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "11095724", "url": "https://glygen.org/publication/PubMed/11095724" } ] }, { "title": "Protein kinase C-related kinase 2 phosphorylates the protein synthesis initiation factor eIF4E in starfish oocytes.", "journal": "Developmental biology", "date": "2000", "authors": "Lee SJ, Stapleton G, Greene JH, Hille MB", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "11112322", "url": "https://glygen.org/publication/PubMed/11112322" } ] }, { "title": "Ubiquitination of HIV-1 and MuLV Gag.", "journal": "Virology", "date": "2000", "authors": "Ott DE, Coren LV, Chertova EN, Gagliardi TD, Schubert U", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "11112487", "url": "https://glygen.org/publication/PubMed/11112487" } ] }, { "title": "The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.", "journal": "Molecular and cellular biology", "date": "2001", "authors": "Scheper GC, Morrice NA, Kleijn M, Proud CG", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "11154262", "url": "https://glygen.org/publication/PubMed/11154262" } ] }, { "title": "Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein.", "journal": "The EMBO journal", "date": "2001", "authors": "Yuan W, Krug RM", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "11157743", "url": "https://glygen.org/publication/PubMed/11157743" } ] }, { "title": "The cap-to-tail guide to mRNA turnover.", "journal": "Nature reviews. Molecular cell biology", "date": "2001", "authors": "Wilusz CJ, Wormington M, Peltz SW", "evidence": [ { "database": "Reactome", "id": "R-HSA-429947", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-429947" } ], "reference": [ { "type": "PubMed", "id": "11283721", "url": "https://glygen.org/publication/PubMed/11283721" } ] }, { "title": "Modifications of eukaryotic initiation factor 4F (eIF4F) in adult cardiocytes by adenoviral gene transfer: differential effects on eIF4F activity and total protein synthesis rates.", "journal": "The Biochemical journal", "date": "2001-06-01", "authors": "Saghir A N, Tuxworth W J, Hagedorn C H, McDermott P J", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "11368785", "url": "https://glygen.org/publication/PubMed/11368785" } ] }, { "title": "Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Li W, Belsham G J, Proud C G", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "11408474", "url": "https://glygen.org/publication/PubMed/11408474" } ] }, { "title": "Coupled transcription and translation within nuclei of mammalian cells.", "journal": "Science", "date": "2001", "authors": "Iborra F J, Jackson D A, Cook P R", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "11423616", "url": "https://glygen.org/publication/PubMed/11423616" } ] }, { "title": "Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2.", "journal": "Molecular and cellular biology", "date": "2001", "authors": "Knauf U, Tschopp C, Gram H", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "11463832", "url": "https://glygen.org/publication/PubMed/11463832" } ] }, { "title": "PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA.", "journal": "EMBO J.", "date": "2001", "authors": "Cohen N, Sharma M, Kentsis A, Perez J M, Strudwick S, Borden K L", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "11500381", "url": "https://glygen.org/publication/PubMed/11500381" } ] }, { "title": "The RING domains of the promyelocytic leukemia protein PML and the arenaviral protein Z repress translation by directly inhibiting translation initiation factor eIF4E.", "journal": "J. Mol. Biol.", "date": "2001", "authors": "Kentsis A, Dwyer E C, Perez J M, Sharma M, Chen A, Pan Z Q, Borden K L", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "11575918", "url": "https://glygen.org/publication/PubMed/11575918" } ] }, { "title": "Phosphorylation of eukaryotic initiation factor 4E (eIF4E) at Ser209 is not required for protein synthesis in vitro and in vivo.", "journal": "European journal of biochemistry", "date": "2001", "authors": "McKendrick L, Morley SJ, Pain VM, Jagus R, Joshi B", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "11606200", "url": "https://glygen.org/publication/PubMed/11606200" } ] }, { "title": "Phosphorylation of eukaryotic initiation factor 4E markedly reduces its affinity for capped mRNA.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Scheper GC, van Kollenburg B, Hu J, Luo Y, Goss DJ, Proud CG", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "11723111", "url": "https://glygen.org/publication/PubMed/11723111" } ] }, { "title": "UBP43 (USP18) specifically removes ISG15 from conjugated proteins.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Malakhov MP, Malakhova OA, Kim KI, Ritchie KJ, Zhang DE", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "11788588", "url": "https://glygen.org/publication/PubMed/11788588" } ] }, { "title": "Crystal structures of 7-methylguanosine 5'-triphosphate (m(7)GTP)- and P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate (m(7)GpppA)-bound human full-length eukaryotic initiation factor 4E: biological importance of the C-terminal flexible region.", "journal": "Biochem. J.", "date": "2002", "authors": "Tomoo K, Shen X, Okabe K, Nozoe Y, Fukuhara S, Morino S, Ishida T, Taniguchi T, Hasegawa H, Terashima A, Sasaki M, Katsuya Y, Kitamura K, Miyoshi H, Ishikawa M, Miura K", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "RefSeq", "id": "NP_001317946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317946" } ], "reference": [ { "type": "PubMed", "id": "11879179", "url": "https://glygen.org/publication/PubMed/11879179" } ] }, { "title": "CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase.", "journal": "The EMBO journal", "date": "2002", "authors": "Chen J, Chiang YC, Denis CL", "evidence": [ { "database": "Reactome", "id": "R-HSA-429947", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-429947" } ], "reference": [ { "type": "PubMed", "id": "11889047", "url": "https://glygen.org/publication/PubMed/11889047" } ] }, { "title": "An element in the 3' untranslated region of human LINE-1 retrotransposon mRNA binds NXF1(TAP) and can function as a nuclear export element.", "journal": "RNA (New York, N.Y.)", "date": "2002", "authors": "Lindtner S, Felber BK, Kjems J", "evidence": [ { "database": "Reactome", "id": "R-HSA-159227", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159227" } ], "reference": [ { "type": "PubMed", "id": "12003494", "url": "https://glygen.org/publication/PubMed/12003494" } ] }, { "title": "Phosphorylation of eukaryotic initiation factor (eIF) 4E is not required for de novo protein synthesis following recovery from hypertonic stress in human kidney cells.", "journal": "The Journal of biological chemistry", "date": "2002-09-06", "authors": "Morley Simon J, Naegele Susanne", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "12138083", "url": "https://glygen.org/publication/PubMed/12138083" } ] }, { "title": "Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.", "journal": "Cell", "date": "2002", "authors": "Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, Hidayat S, Tokunaga C, Avruch J, Yonezawa K", "evidence": [ { "database": "Reactome", "id": "R-HSA-166208", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166208" } ], "reference": [ { "type": "PubMed", "id": "12150926", "url": "https://glygen.org/publication/PubMed/12150926" } ] }, { "title": "Overlapping motifs (PTAP and PPEY) within the Ebola virus VP40 protein function independently as late budding domains: involvement of host proteins TSG101 and VPS-4.", "journal": "Journal of virology", "date": "2003", "authors": "Licata JM, Simpson-Holley M, Wright NT, Han Z, Paragas J, Harty RN", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "12525615", "url": "https://glygen.org/publication/PubMed/12525615" } ] }, { "title": "The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth.", "journal": "EMBO J.", "date": "2003", "authors": "Topisirovic Ivan, Culjkovic Biljana, Cohen Natalie, Perez Jacqueline M, Skrabanek Lucy, Borden Katherine L B", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "12554669", "url": "https://glygen.org/publication/PubMed/12554669" } ] }, { "title": "Phosphorylation of eIF4E attenuates its interaction with mRNA 5' cap analogs by electrostatic repulsion: intein-mediated protein ligation strategy to obtain phosphorylated protein.", "journal": "RNA (New York, N.Y.)", "date": "2003", "authors": "Zuberek J, Wyslouch-Cieszynska A, Niedzwiecka A, Dadlez M, Stepinski J, Augustyniak W, Gingras AC, Zhang Z, Burley SK, Sonenberg N, Stolarski R, Darzynkiewicz E", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "12554876", "url": "https://glygen.org/publication/PubMed/12554876" } ] }, { "title": "High-throughput immunoblotting. Ubiquitiin-like protein ISG15 modifies key regulators of signal transduction.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Malakhov MP, Kim KI, Malakhova OA, Jacobs BS, Borden EC, Zhang DE", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "12582176", "url": "https://glygen.org/publication/PubMed/12582176" } ] }, { "title": "Transcript-selective translational silencing by gamma interferon is directed by a novel structural element in the ceruloplasmin mRNA 3' untranslated region.", "journal": "Molecular and cellular biology", "date": "2003", "authors": "Sampath P, Mazumder B, Seshadri V, Fox PL", "evidence": [ { "database": "Reactome", "id": "R-HSA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156827" } ], "reference": [ { "type": "PubMed", "id": "12588972", "url": "https://glygen.org/publication/PubMed/12588972" } ] }, { "title": "Structural features of human initiation factor 4E, studied by X-ray crystal analyses and molecular dynamics simulations.", "journal": "Journal of molecular biology", "date": "2003", "authors": "Tomoo K, Shen X, Okabe K, Nozoe Y, Fukuhara S, Morino S, Sasaki M, Taniguchi T, Miyagawa H, Kitamura K, Miura K, Ishida T", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "12691746", "url": "https://glygen.org/publication/PubMed/12691746" } ] }, { "title": "Sirolimus: its discovery, biological properties, and mechanism of action.", "journal": "Transplantation proceedings", "date": "2003", "authors": "Sehgal SN", "evidence": [ { "database": "Reactome", "id": "R-HSA-166208", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166208" } ], "reference": [ { "type": "PubMed", "id": "12742462", "url": "https://glygen.org/publication/PubMed/12742462" } ] }, { "title": "A role for PYK2 in ANG II-dependent regulation of the PHAS-1-eIF4E complex by multiple signaling cascades in vascular smooth muscle.", "journal": "American journal of physiology. Cell physiology", "date": "2003", "authors": "Rocic P, Jo H, Lucchesi PA", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "12890645", "url": "https://glygen.org/publication/PubMed/12890645" } ] }, { "title": "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization.", "journal": "Mol. Cell. Biol.", "date": "2003", "authors": "Scheper GC, Parra JL, Wilson M, Van Kollenburg B, Vertegaal AC, Han ZG, Proud CG", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "iPTMnet", "id": "P06730-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730-1" } ], "reference": [ { "type": "PubMed", "id": "12897141", "url": "https://glygen.org/publication/PubMed/12897141" } ] }, { "title": "Backbone resonance assignment of human eukaryotic translation initiation factor 4E (eIF4E) in complex with 7-methylguanosine diphosphate (m7GDP) and a 17-amino acid peptide derived from human eIF4GII.", "journal": "J. Biomol. NMR", "date": "2003", "authors": "Miura Takaaki, Shiratori Yasuhiko, Shimma Nobuo", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "12975586", "url": "https://glygen.org/publication/PubMed/12975586" } ] }, { "title": "Properties of a HeLa cell 3' exonuclease specific for degrading poly(A) tails of mammalian mRNA.", "journal": "The Journal of biological chemistry", "date": "1992", "authors": "Astrom J, Astrom A, Virtanen A", "evidence": [ { "database": "Reactome", "id": "R-HSA-429947", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-429947" } ], "reference": [ { "type": "PubMed", "id": "1355481", "url": "https://glygen.org/publication/PubMed/1355481" } ] }, { "title": "A fraction of the mRNA 5' cap-binding protein, eukaryotic initiation factor 4E, localizes to the nucleus.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1992", "authors": "Lejbkowicz F, Goyer C, Darveau A, Neron S, Lemieux R, Sonenberg N", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "1384058", "url": "https://glygen.org/publication/PubMed/1384058" } ] }, { "title": "Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control.", "journal": "Cell", "date": "2003", "authors": "Mazumder B, Sampath P, Seshadri V, Maitra RK, DiCorleto PE, Fox PL", "evidence": [ { "database": "Reactome", "id": "R-HSA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156827" } ], "reference": [ { "type": "PubMed", "id": "14567916", "url": "https://glygen.org/publication/PubMed/14567916" } ] }, { "title": "Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Uchida N, Hoshino S, Katada T", "evidence": [ { "database": "Reactome", "id": "R-HSA-429947", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-429947" } ], "reference": [ { "type": "PubMed", "id": "14583602", "url": "https://glygen.org/publication/PubMed/14583602" } ] }, { "title": "The enzymes and control of eukaryotic mRNA turnover.", "journal": "Nature structural & molecular biology", "date": "2004", "authors": "Parker R, Song H", "evidence": [ { "database": "Reactome", "id": "R-HSA-429947", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-429947" } ], "reference": [ { "type": "PubMed", "id": "14749774", "url": "https://glygen.org/publication/PubMed/14749774" } ] }, { "title": "Nuclear export of mRNA: from the site of transcription to the cytoplasm.", "journal": "Experimental cell research", "date": "2004", "authors": "Erkmann JA, Kutay U", "evidence": [ { "database": "Reactome", "id": "R-HSA-159231", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159231" } ], "reference": [ { "type": "PubMed", "id": "15120988", "url": "https://glygen.org/publication/PubMed/15120988" } ] }, { "title": "Influence of electric charge variation at residues 209 and 159 on the interaction of eIF4E with the mRNA 5' terminus.", "journal": "Biochemistry", "date": "2004", "authors": "Zuberek J, Jemielity J, Jablonowska A, Stepinski J, Dadlez M, Stolarski R, Darzynkiewicz E", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "15122903", "url": "https://glygen.org/publication/PubMed/15122903" } ] }, { "title": "The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2004", "authors": "Zhao C, Beaudenon SL, Kelley ML, Waddell MB, Yuan W, Schulman BA, Huibregtse JM, Krug RM", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "15131269", "url": "https://glygen.org/publication/PubMed/15131269" } ] }, { "title": "Phosphorylation states of translational initiation factors affect mRNA cap binding in wheat.", "journal": "Biochemistry", "date": "2004", "authors": "Khan MA, Goss DJ", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "15248766", "url": "https://glygen.org/publication/PubMed/15248766" } ] }, { "title": "Upstream and downstream of mTOR.", "journal": "Genes & development", "date": "2004", "authors": "Hay N, Sonenberg N", "evidence": [ { "database": "Reactome", "id": "R-HSA-166208", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166208" } ], "reference": [ { "type": "PubMed", "id": "15314020", "url": "https://glygen.org/publication/PubMed/15314020" } ] }, { "title": "Messenger RNA decay in mammalian cells: the exonuclease perspective.", "journal": "Cell biochemistry and biophysics", "date": "2004", "authors": "Fritz DT, Bergman N, Kilpatrick WJ, Wilusz CJ, Wilusz J", "evidence": [ { "database": "Reactome", "id": "R-HSA-429947", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-429947" } ], "reference": [ { "type": "PubMed", "id": "15475613", "url": "https://glygen.org/publication/PubMed/15475613" } ] }, { "title": "Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation.", "journal": "Molecular and cellular biology", "date": "2004", "authors": "Kim KI, Giannakopoulos NV, Virgin HW, Zhang DE", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "15485925", "url": "https://glygen.org/publication/PubMed/15485925" } ] }, { "title": "Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities.", "journal": "Cancer research", "date": "2004", "authors": "Topisirovic I, Ruiz-Gutierrez M, Borden KL", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "15574771", "url": "https://glygen.org/publication/PubMed/15574771" } ] }, { "title": "Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2004-12-28", "authors": "Kentsis Alex, Topisirovic Ivan, Culjkovic Biljana, Shao Ling, Borden Katherine L B", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "15601771", "url": "https://glygen.org/publication/PubMed/15601771" } ] }, { "title": "Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels.", "journal": "Mol. Cell. Biol.", "date": "2005", "authors": "Topisirovic Ivan, Kentsis Alex, Perez Jacqueline M, Guzman Monica L, Jordan Craig T, Borden Katherine L B", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "15657436", "url": "https://glygen.org/publication/PubMed/15657436" } ] }, { "title": "An unconventional NLS is critical for the nuclear import of the influenza A virus nucleoprotein and ribonucleoprotein.", "journal": "Traffic (Copenhagen, Denmark)", "date": "2005", "authors": "Cros JF, Garcia-Sastre A, Palese P", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "15702989", "url": "https://glygen.org/publication/PubMed/15702989" } ] }, { "title": "Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Ali SM, Sabatini DM", "evidence": [ { "database": "Reactome", "id": "R-HSA-166208", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166208" } ], "reference": [ { "type": "PubMed", "id": "15809305", "url": "https://glygen.org/publication/PubMed/15809305" } ] }, { "title": "Ras transformation of cloned rat embryo fibroblasts results in increased rates of protein synthesis and phosphorylation of eukaryotic initiation factor 4E.", "journal": "The Journal of biological chemistry", "date": "1992", "authors": "Rinker-Schaeffer CW, Austin V, Zimmer S, Rhoads RE", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "1587843", "url": "https://glygen.org/publication/PubMed/1587843" } ] }, { "title": "Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2005", "authors": "Zhao C, Denison C, Huibregtse JM, Gygi S, Krug RM", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "16009940", "url": "https://glygen.org/publication/PubMed/16009940" } ] }, { "title": "ISG15 modification of Ubc13 suppresses its ubiquitin-conjugating activity.", "journal": "Biochemical and biophysical research communications", "date": "2005", "authors": "Takeuchi T, Yokosawa H", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "16112642", "url": "https://glygen.org/publication/PubMed/16112642" } ] }, { "title": "ISG15 modification of ubiquitin E2 Ubc13 disrupts its ability to form thioester bond with ubiquitin.", "journal": "Biochemical and biophysical research communications", "date": "2005", "authors": "Zou W, Papov V, Malakhova O, Kim KI, Dao C, Li J, Zhang DE", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "16122702", "url": "https://glygen.org/publication/PubMed/16122702" } ] }, { "title": "Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.", "journal": "Biochemical and biophysical research communications", "date": "2005", "authors": "Giannakopoulos NV, Luo JK, Papov V, Zou W, Lenschow DJ, Jacobs BS, Borden EC, Li J, Virgin HW, Zhang DE", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "16139798", "url": "https://glygen.org/publication/PubMed/16139798" } ] }, { "title": "From birth to death: the complex lives of eukaryotic mRNAs.", "journal": "Science (New York, N.Y.)", "date": "2005", "authors": "Moore MJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-429947", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-429947" } ], "reference": [ { "type": "PubMed", "id": "16141059", "url": "https://glygen.org/publication/PubMed/16141059" } ] }, { "title": "A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay.", "journal": "J. Cell Biol.", "date": "2005", "authors": "Ferraiuolo MA, Basak S, Dostie J, Murray EL, Schoenberg DR, Sonenberg N", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "16157702", "url": "https://glygen.org/publication/PubMed/16157702" } ] }, { "title": "Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods.", "journal": "Biochimica et biophysica acta", "date": "2005-12-01", "authors": "Tomoo Koji, Matsushita Yasunori, Fujisaki Hiroyuki, Abiko Fumi, Shen Xu, Taniguchi Taizo, Miyagawa Hiroo, Kitamura Kunihiro, Miura Kin-ichiro, Ishida Toshimasa", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "16271312", "url": "https://glygen.org/publication/PubMed/16271312" } ] }, { "title": "Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover.", "journal": "Nature structural & molecular biology", "date": "2005", "authors": "Yamashita A, Chang TC, Yamashita Y, Zhu W, Zhong Z, Chen CY, Shyu AB", "evidence": [ { "database": "Reactome", "id": "R-HSA-429947", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-429947" } ], "reference": [ { "type": "PubMed", "id": "16284618", "url": "https://glygen.org/publication/PubMed/16284618" } ] }, { "title": "Transcriptome analysis of human gastric cancer.", "journal": "Mamm. Genome", "date": "2005", "authors": "Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "16341674", "url": "https://glygen.org/publication/PubMed/16341674" } ] }, { "title": "The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Zou W, Zhang DE", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "16352599", "url": "https://glygen.org/publication/PubMed/16352599" } ] }, { "title": "Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Dastur A, Beaudenon S, Kelley M, Krug RM, Huibregtse JM", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "16407192", "url": "https://glygen.org/publication/PubMed/16407192" } ] }, { "title": "Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme.", "journal": "Journal of biochemistry", "date": "2005", "authors": "Takeuchi T, Iwahara S, Saeki Y, Sasajima H, Yokosawa H", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "16428300", "url": "https://glygen.org/publication/PubMed/16428300" } ] }, { "title": "Stopped-flow kinetic analysis of eIF4E and phosphorylated eIF4E binding to cap analogs and capped oligoribonucleotides: evidence for a one-step binding mechanism.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Slepenkov SV, Darzynkiewicz E, Rhoads RE", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "16540463", "url": "https://glygen.org/publication/PubMed/16540463" } ] }, { "title": "Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1.", "journal": "Nature immunology", "date": "2006", "authors": "Saitoh T, Tun-Kyi A, Ryo A, Yamamoto M, Finn G, Fujita T, Akira S, Yamamoto N, Lu KP, Yamaoka S", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "16699525", "url": "https://glygen.org/publication/PubMed/16699525" } ] }, { "title": "Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies.", "journal": "PLoS Pathog.", "date": "2006", "authors": "Wichroski MJ, Robb GB, Rana TM", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "16699599", "url": "https://glygen.org/publication/PubMed/16699599" } ] }, { "title": "Pin-ning down immune responses to RNA viruses.", "journal": "Nature immunology", "date": "2006", "authors": "Goutagny N, Severa M, Fitzgerald KA", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "16715065", "url": "https://glygen.org/publication/PubMed/16715065" } ] }, { "title": "Combination of Trp and Glu residues for recognition of mRNA cap structure. Analysis of m7G base recognition site of human cap binding protein (IF-4E) by site-directed mutagenesis.", "journal": "FEBS letters", "date": "1991", "authors": "Ueda H, Iyo H, Doi M, Inoue M, Ishida T, Morioka H, Tanaka T, Nishikawa S, Uesugi S", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "1672854", "url": "https://glygen.org/publication/PubMed/1672854" } ] }, { "title": "Cumulative mutations of ubiquitin acceptor sites in human immunodeficiency virus type 1 gag cause a late budding defect.", "journal": "Journal of virology", "date": "2006", "authors": "Gottwein E, Jager S, Habermann A, Krausslich HG", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "16775314", "url": "https://glygen.org/publication/PubMed/16775314" } ] }, { "title": "HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2006", "authors": "Wong JJ, Pung YF, Sze NS, Chin KC", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "16815975", "url": "https://glygen.org/publication/PubMed/16815975" } ] }, { "title": "Negative regulation of protein phosphatase 2Cbeta by ISG15 conjugation.", "journal": "FEBS letters", "date": "2006", "authors": "Takeuchi T, Kobayashi T, Tamura S, Yokosawa H", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "16872604", "url": "https://glygen.org/publication/PubMed/16872604" } ] }, { "title": "ISG15 enhances the innate antiviral response by inhibition of IRF-3 degradation.", "journal": "Cellular and molecular biology (Noisy-le-Grand, France)", "date": "2006", "authors": "Lu G, Reinert JT, Pitha-Rowe I, Okumura A, Kellum M, Knobeloch KP, Hassel B, Pitha PM", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "16914094", "url": "https://glygen.org/publication/PubMed/16914094" } ] }, { "title": "Pifithrin-alpha enhances chemosensitivity by a p38 mitogen-activated protein kinase-dependent modulation of the eukaryotic initiation factor 4E in malignant cholangiocytes.", "journal": "The Journal of pharmacology and experimental therapeutics", "date": "2006-12", "authors": "Wehbe Hania, Henson Roger, Lang Molly, Meng Fanyin, Patel Tushar", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "16982703", "url": "https://glygen.org/publication/PubMed/16982703" } ] }, { "title": "Cap-free structure of eIF4E suggests a basis for conformational regulation by its ligands.", "journal": "The EMBO journal", "date": "2006", "authors": "Volpon L, Osborne MJ, Topisirovic I, Siddiqui N, Borden KL", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "17036047", "url": "https://glygen.org/publication/PubMed/17036047" } ] }, { "title": "Opposing polymerase-deadenylase activities regulate cytoplasmic polyadenylation.", "journal": "Molecular cell", "date": "2006", "authors": "Kim JH, Richter JD", "evidence": [ { "database": "Reactome", "id": "R-HSA-429947", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-429947" } ], "reference": [ { "type": "PubMed", "id": "17052452", "url": "https://glygen.org/publication/PubMed/17052452" } ] }, { "title": "Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes.", "journal": "Cell", "date": "1991", "authors": "Liu J, Farmer JD Jr, Lane WS, Friedman J, Weissman I, Schreiber SL", "evidence": [ { "database": "Reactome", "id": "R-HSA-166208", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166208" } ], "reference": [ { "type": "PubMed", "id": "1715244", "url": "https://glygen.org/publication/PubMed/1715244" } ] }, { "title": "The highways and byways of mRNA decay.", "journal": "Nature reviews. Molecular cell biology", "date": "2007", "authors": "Garneau NL, Wilusz J, Wilusz CJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-429947", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-429947" } ], "reference": [ { "type": "PubMed", "id": "17245413", "url": "https://glygen.org/publication/PubMed/17245413" } ] }, { "title": "ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP.", "journal": "Genes & development", "date": "2007", "authors": "Okumura F, Zou W, Zhang DE", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "17289916", "url": "https://glygen.org/publication/PubMed/17289916" } ] }, { "title": "CRM1-mediated nuclear export: to the pore and beyond.", "journal": "Trends in cell biology", "date": "2007", "authors": "Hutten S, Kehlenbach RH", "evidence": [ { "database": "Reactome", "id": "R-HSA-159231", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159231" } ], "reference": [ { "type": "PubMed", "id": "17317185", "url": "https://glygen.org/publication/PubMed/17317185" } ] }, { "title": "Nuclear and nucleolar targeting of influenza A virus NS1 protein: striking differences between different virus subtypes.", "journal": "Journal of virology", "date": "2007", "authors": "Melen K, Kinnunen L, Fagerlund R, Ikonen N, Twu KY, Krug RM, Julkunen I", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "17376915", "url": "https://glygen.org/publication/PubMed/17376915" } ] }, { "title": "Poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Siddiqui N, Mangus DA, Chang TC, Palermino JM, Shyu AB, Gehring K", "evidence": [ { "database": "Reactome", "id": "R-HSA-429947", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-429947" } ], "reference": [ { "type": "PubMed", "id": "17595167", "url": "https://glygen.org/publication/PubMed/17595167" } ] }, { "title": "Crystallographic and mass spectrometric characterisation of eIF4E with N7-alkylated cap derivatives.", "journal": "J. Mol. Biol.", "date": "2007", "authors": "Brown CJ, McNae I, Fischer PM, Walkinshaw MD", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "RefSeq", "id": "NP_001317946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317946" } ], "reference": [ { "type": "PubMed", "id": "17631896", "url": "https://glygen.org/publication/PubMed/17631896" } ] }, { "title": "Candidate tumor suppressor DDX3 RNA helicase specifically represses cap-dependent translation by acting as an eIF4E inhibitory protein.", "journal": "Oncogene", "date": "2008", "authors": "Shih JW, Tsai TY, Chao CH, Wu Lee YH", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "17667941", "url": "https://glygen.org/publication/PubMed/17667941" } ] }, { "title": "Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation.", "journal": "Molecular and cellular biology", "date": "2007", "authors": "Wang X, Yue P, Chan CB, Ye K, Ueda T, Watanabe-Fukunaga R, Fukunaga R, Fu H, Khuri FR, Sun SY", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "17724079", "url": "https://glygen.org/publication/PubMed/17724079" } ] }, { "title": "ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Malakhova OA, Zhang DE", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "18287095", "url": "https://glygen.org/publication/PubMed/18287095" } ] }, { "title": "ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Okumura A, Pitha PM, Harty RN", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "18305167", "url": "https://glygen.org/publication/PubMed/18305167" } ] }, { "title": "Differences in muscle protein synthesis and anabolic signaling in the postabsorptive state and in response to food in 65-80 year old men and women.", "journal": "PloS one", "date": "2008", "authors": "Smith GI, Atherton P, Villareal DT, Frimel TN, Rankin D, Rennie MJ, Mittendorfer B", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "18365020", "url": "https://glygen.org/publication/PubMed/18365020" } ] }, { "title": "Function of eukaryotic initiation factor 5 in the formation of an 80 S ribosomal polypeptide chain initiation complex.", "journal": "The Journal of biological chemistry", "date": "1991", "authors": "Chakrabarti A, Maitra U", "evidence": [ { "database": "Reactome", "id": "R-HSA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72706" } ], "reference": [ { "type": "PubMed", "id": "1856230", "url": "https://glygen.org/publication/PubMed/1856230" } ] }, { "title": "The basis for selective E1-E2 interactions in the ISG15 conjugation system.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Durfee LA, Kelley ML, Huibregtse JM", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "18583345", "url": "https://glygen.org/publication/PubMed/18583345" } ] }, { "title": "Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells.", "journal": "The Journal of cell biology", "date": "2008", "authors": "Zheng D, Ezzeddine N, Chen CY, Zhu W, He X, Shyu AB", "evidence": [ { "database": "Reactome", "id": "R-HSA-429947", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-429947" } ], "reference": [ { "type": "PubMed", "id": "18625844", "url": "https://glygen.org/publication/PubMed/18625844" } ] }, { "title": "ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus.", "journal": "Journal of virology", "date": "2009", "authors": "Giannakopoulos NV, Arutyunova E, Lai C, Lenschow DJ, Haas AL, Virgin HW", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "19073728", "url": "https://glygen.org/publication/PubMed/19073728" } ] }, { "title": "Inhibition of IRF3-dependent antiviral responses by cellular and viral proteins.", "journal": "Cell research", "date": "2009", "authors": "Tsuchida T, Kawai T, Akira S", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "19125153", "url": "https://glygen.org/publication/PubMed/19125153" } ] }, { "title": "The many pathways of RNA degradation.", "journal": "Cell", "date": "2009", "authors": "Houseley J, Tollervey D", "evidence": [ { "database": "Reactome", "id": "R-HSA-429947", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-429947" } ], "reference": [ { "type": "PubMed", "id": "19239894", "url": "https://glygen.org/publication/PubMed/19239894" } ] }, { "title": "Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP.", "journal": "EMBO J.", "date": "2009", "authors": "Topisirovic Ivan, Siddiqui Nadeem, Lapointe Vincent Leroux, Trost Matthias, Thibault Pierre, Bangeranye Catherine, Pi\u00f1ol-Roma Serafin, Borden Katherine L B", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "19262567", "url": "https://glygen.org/publication/PubMed/19262567" } ] }, { "title": "ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway.", "journal": "EMBO reports", "date": "2009", "authors": "Jeon YJ, Choi JS, Lee JY, Yu KR, Kim SM, Ka SH, Oh KH, Kim KI, Zhang DE, Bang OS, Chung CH", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "19270716", "url": "https://glygen.org/publication/PubMed/19270716" } ] }, { "title": "Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin.", "journal": "Blood", "date": "2009", "authors": "Assouline Sarit, Culjkovic Biljana, Cocolakis Eftihia, Rousseau Caroline, Beslu Nathalie, Amri Abdellatif, Caplan Stephen, Leber Brian, Roy Denis-Claude, Miller Wilson H, Borden Katherine L B", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "19433856", "url": "https://glygen.org/publication/PubMed/19433856" } ] }, { "title": "mRNA nuclear export at a glance.", "journal": "Journal of cell science", "date": "2009", "authors": "Carmody SR, Wente SR", "evidence": [ { "database": "Reactome", "id": "R-HSA-159231", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159231" } ], "reference": [ { "type": "PubMed", "id": "19494120", "url": "https://glygen.org/publication/PubMed/19494120" } ] }, { "title": "Deregulation of EIF4E: a novel mechanism for autism.", "journal": "J. Med. Genet.", "date": "2009", "authors": "Neves-Pereira M, M\u00fcller B, Massie D, Williams J H G, O'Brien P C M, Hughes A, Shen S-B, Clair David St, Miedzybrodzka Z", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "19556253", "url": "https://glygen.org/publication/PubMed/19556253" } ] }, { "title": "Human Ccr4-Not complexes contain variable deadenylase subunits.", "journal": "The Biochemical journal", "date": "2009", "authors": "Lau NC, Kolkman A, van Schaik FM, Mulder KW, Pijnappel WW, Heck AJ, Timmers HT", "evidence": [ { "database": "Reactome", "id": "R-HSA-429947", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-429947" } ], "reference": [ { "type": "PubMed", "id": "19558367", "url": "https://glygen.org/publication/PubMed/19558367" } ] }, { "title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Pan C, Olsen JV, Daub H, Mann M", "evidence": [ { "database": "iPTMnet", "id": "P06730-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730-1" } ], "reference": [ { "type": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ] }, { "title": "Phosphorylation dynamics during early differentiation of human embryonic stem cells.", "journal": "Cell stem cell", "date": "2009", "authors": "Van Hoof D, Munoz J, Braam SR, Pinkse MW, Linding R, Heck AJ, Mummery CL, Krijgsveld J", "evidence": [ { "database": "iPTMnet", "id": "P06730-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730-1" } ], "reference": [ { "type": "PubMed", "id": "19664995", "url": "https://glygen.org/publication/PubMed/19664995" } ] }, { "title": "Regulation of host translational machinery by African swine fever virus.", "journal": "PLoS pathogens", "date": "2009", "authors": "Castello A, Quintas A, Sanchez EG, Sabina P, Nogal M, Carrasco L, Revilla Y", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "19714237", "url": "https://glygen.org/publication/PubMed/19714237" } ] }, { "title": "Differential regulation of CHOP translation by phosphorylated eIF4E under stress conditions.", "journal": "Nucleic acids research", "date": "2010", "authors": "Chen YJ, Tan BC, Cheng YY, Chen JS, Lee SC", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "19934253", "url": "https://glygen.org/publication/PubMed/19934253" } ] }, { "title": "Phosphorylation of the proto-oncogene product eukaryotic initiation factor 4E is a common cellular response to tumor necrosis factor.", "journal": "J. Biol. Chem.", "date": "1991", "authors": "Marino M W, Feld L J, Jaffe E A, Pfeffer L M, Han H M, Donner D B", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "1993647", "url": "https://glygen.org/publication/PubMed/1993647" } ] }, { "title": "Arginine methylation of REF/ALY promotes efficient handover of mRNA to TAP/NXF1.", "journal": "Nucleic acids research", "date": "2010", "authors": "Hung ML, Hautbergue GM, Snijders AP, Dickman MJ, Wilson SA", "evidence": [ { "database": "Reactome", "id": "R-HSA-159230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159230" } ], "reference": [ { "type": "PubMed", "id": "20129943", "url": "https://glygen.org/publication/PubMed/20129943" } ] }, { "title": "ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2010", "authors": "Zhao C, Hsiang TY, Kuo RL, Krug RM", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "20133869", "url": "https://glygen.org/publication/PubMed/20133869" } ] }, { "title": "Regulation of histone mRNA in the unperturbed cell cycle: evidence suggesting control at two posttranscriptional steps.", "journal": "Molecular and cellular biology", "date": "1991", "authors": "Harris ME, Bohni R, Schneiderman MH, Ramamurthy L, Schumperli D, Marzluff WF", "evidence": [ { "database": "Reactome", "id": "R-HSA-159231", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159231" } ], "reference": [ { "type": "PubMed", "id": "2017161", "url": "https://glygen.org/publication/PubMed/2017161" } ] }, { "title": "Structural characterization of the Z RING-eIF4E complex reveals a distinct mode of control for eIF4E.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2010", "authors": "Volpon Laurent, Osborne Michael J, Capul Althea A, de la Torre Juan C, Borden Katherine L B", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "20212144", "url": "https://glygen.org/publication/PubMed/20212144" } ] }, { "title": "Species-specific antagonism of host ISGylation by the influenza B virus NS1 protein.", "journal": "Journal of virology", "date": "2010", "authors": "Versteeg GA, Hale BG, van Boheemen S, Wolff T, Lenschow DJ, Garcia-Sastre A", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "20219937", "url": "https://glygen.org/publication/PubMed/20219937" } ] }, { "title": "Sumoylation of eIF4E activates mRNA translation.", "journal": "EMBO reports", "date": "2010", "authors": "Xu X, Vatsyayan J, Gao C, Bakkenist CJ, Hu J", "evidence": [ { "database": "RefSeq", "id": "NP_001317946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317946" } ], "reference": [ { "type": "PubMed", "id": "20224576", "url": "https://glygen.org/publication/PubMed/20224576" } ] }, { "title": "Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification.", "journal": "Molecular and cellular biology", "date": "2010", "authors": "Shi HX, Yang K, Liu X, Liu XY, Wei B, Shan YF, Zhu LH, Wang C", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "20308324", "url": "https://glygen.org/publication/PubMed/20308324" } ] }, { "title": "Herc5 attenuates influenza A virus by catalyzing ISGylation of viral NS1 protein.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2010", "authors": "Tang Y, Zhong G, Zhu L, Liu X, Shan Y, Feng H, Bu Z, Chen H, Wang C", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "20385878", "url": "https://glygen.org/publication/PubMed/20385878" } ] }, { "title": "The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration.", "journal": "Nucleic Acids Res.", "date": "2010", "authors": "Burrows C, Abd Latip N, Lam SJ, Carpenter L, Sawicka K, Tzolovsky G, Gabra H, Bushell M, Glover DM, Willis AE, Blagden SP", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "20430826", "url": "https://glygen.org/publication/PubMed/20430826" } ] }, { "title": "LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2010", "authors": "James V, Zhang Y, Foxler DE, de Moor CH, Kong YW, Webb TM, Self TJ, Feng Y, Lagos D, Chu CY, Rana TM, Morley SJ, Longmore GD, Bushell M, Sharp TV", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "20616046", "url": "https://glygen.org/publication/PubMed/20616046" } ] }, { "title": "The nuclear pore complex and nuclear transport.", "journal": "Cold Spring Harbor perspectives in biology", "date": "2010", "authors": "Wente SR, Rout MP", "evidence": [ { "database": "Reactome", "id": "R-HSA-159231", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159231" } ], "reference": [ { "type": "PubMed", "id": "20630994", "url": "https://glygen.org/publication/PubMed/20630994" } ] }, { "title": "Negative regulatory effects of Mnk kinases in the generation of chemotherapy-induced antileukemic responses.", "journal": "Molecular pharmacology", "date": "2010", "authors": "Altman JK, Glaser H, Sassano A, Joshi S, Ueda T, Watanabe-Fukunaga R, Fukunaga R, Tallman MS, Platanias LC", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "20664001", "url": "https://glygen.org/publication/PubMed/20664001" } ] }, { "title": "The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survival.", "journal": "Cancer biology & therapy", "date": "2010", "authors": "Wheater MJ, Johnson PW, Blaydes JP", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "20686366", "url": "https://glygen.org/publication/PubMed/20686366" } ] }, { "title": "Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach.", "journal": "Journal of medicinal chemistry", "date": "2010", "authors": "Oyarzabal J, Zarich N, Albarran MI, Palacios I, Urbano-Cuadrado M, Mateos G, Reymundo I, Rabal O, Salgado A, Corrionero A, Fominaya J, Pastor J, Bischoff JR", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "20722422", "url": "https://glygen.org/publication/PubMed/20722422" } ] }, { "title": "Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction.", "journal": "Molecular and cellular biology", "date": "2010", "authors": "Shveygert M, Kaiser C, Bradrick SS, Gromeier M", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "20823271", "url": "https://glygen.org/publication/PubMed/20823271" } ] }, { "title": "Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E.", "journal": "Neoplasia (New York, N.Y.)", "date": "2010", "authors": "Li Y, Yue P, Deng X, Ueda T, Fukunaga R, Khuri FR, Sun SY", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "20927323", "url": "https://glygen.org/publication/PubMed/20927323" } ] }, { "title": "Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1990", "authors": "De Benedetti A, Rhoads RE", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "2122455", "url": "https://glygen.org/publication/PubMed/2122455" } ] }, { "title": "Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases.", "journal": "Cancer research", "date": "2011", "authors": "Konicek BW, Stephens JR, McNulty AM, Robichaud N, Peery RB, Dumstorf CA, Dowless MS, Iversen PW, Parsons S, Ellis KE, McCann DJ, Pelletier J, Furic L, Yingling JM, Stancato LF, Sonenberg N, Graff JR", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "21233335", "url": "https://glygen.org/publication/PubMed/21233335" } ] }, { "title": "The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder.", "journal": "Progress in neuro-psychopharmacology & biological psychiatry", "date": "2011", "authors": "Jernigan CS, Goswami DB, Austin MC, Iyo AH, Chandran A, Stockmeier CA, Karolewicz B", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "21635931", "url": "https://glygen.org/publication/PubMed/21635931" } ] }, { "title": "Structural scaffold for eIF4E binding selectivity of 4E-BP isoforms: crystal structure of eIF4E binding region of 4E-BP2 and its comparison with that of 4E-BP1.", "journal": "J. Pept. Sci.", "date": "2011", "authors": "Fukuyo A, In Y, Ishida T, Tomoo K", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "21661078", "url": "https://glygen.org/publication/PubMed/21661078" } ] }, { "title": "Tissue microarray evidence of association between p16 and phosphorylated eIF4E in tonsillar squamous cell carcinoma.", "journal": "Head & neck", "date": "2011", "authors": "Fury MG, Drobnjak M, Sima CS, Asher M, Shah J, Lee N, Carlson D, Wendel HG, Pfister DG", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "21837706", "url": "https://glygen.org/publication/PubMed/21837706" } ] }, { "title": "Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress response.", "journal": "Biochem. J.", "date": "2012", "authors": "Shih JW, Wang WT, Tsai TY, Kuo CY, Li HK, Wu Lee YH", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "21883093", "url": "https://glygen.org/publication/PubMed/21883093" } ] }, { "title": "Simultaneous inhibition of mTOR-containing complex 1 (mTORC1) and MNK induces apoptosis of cutaneous T-cell lymphoma (CTCL) cells.", "journal": "PloS one", "date": "2011", "authors": "Marzec M, Liu X, Wysocka M, Rook AH, Odum N, Wasik MA", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "21949767", "url": "https://glygen.org/publication/PubMed/21949767" } ] }, { "title": "Targeting Mnks for cancer therapy.", "journal": "Oncotarget", "date": "2012", "authors": "Hou J, Lam F, Proud C, Wang S", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "22392765", "url": "https://glygen.org/publication/PubMed/22392765" } ] }, { "title": "Translational homeostasis via the mRNA cap-binding protein, eIF4E.", "journal": "Molecular cell", "date": "2012", "authors": "Yanagiya A, Suyama E, Adachi H, Svitkin YV, Aza-Blanc P, Imataka H, Mikami S, Martineau Y, Ronai ZA, Sonenberg N", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "22578813", "url": "https://glygen.org/publication/PubMed/22578813" } ] }, { "title": "4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2.", "journal": "FEBS letters", "date": "2012", "authors": "Chen CC, Lee JC, Chang MC", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "22684010", "url": "https://glygen.org/publication/PubMed/22684010" } ] }, { "title": "Human intronless genes: functional groups, associated diseases, evolution, and mRNA processing in absence of splicing.", "journal": "Biochemical and biophysical research communications", "date": "2012", "authors": "Grzybowska EA", "evidence": [ { "database": "Reactome", "id": "R-HSA-159227", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159227" } ], "reference": [ { "type": "PubMed", "id": "22732409", "url": "https://glygen.org/publication/PubMed/22732409" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "Human inducible nitric oxide synthase (iNOS) expression depends on chromosome region maintenance 1 (CRM1)- and eukaryotic translation initiation factor 4E (elF4E)-mediated nucleocytoplasmic mRNA transport.", "journal": "Nitric oxide : biology and chemistry", "date": "2013-04-01", "authors": "Bollmann Franziska, Fechir Katrin, Nowag Sebastian, Koch Kathrin, Art Julia, Kleinert Hartmut, Pautz Andrea", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "23471078", "url": "https://glygen.org/publication/PubMed/23471078" } ] }, { "title": "Aiding and abetting cancer: mRNA export and the nuclear pore.", "journal": "Trends in cell biology", "date": "2013", "authors": "Culjkovic-Kraljacic B, Borden KL", "evidence": [ { "database": "Reactome", "id": "R-HSA-159231", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159231" } ], "reference": [ { "type": "PubMed", "id": "23582887", "url": "https://glygen.org/publication/PubMed/23582887" } ] }, { "title": "Structural and biochemical studies of SLIP1-SLBP identify DBP5 and eIF3g as SLIP1-binding proteins.", "journal": "Nucleic acids research", "date": "2013", "authors": "von Moeller H, Lerner R, Ricciardi A, Basquin C, Marzluff WF, Conti E", "evidence": [ { "database": "Reactome", "id": "R-HSA-159231", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159231" } ], "reference": [ { "type": "PubMed", "id": "23804756", "url": "https://glygen.org/publication/PubMed/23804756" } ] }, { "title": "Sphingosine-1-Phosphate as a Regulator of Hypoxia-Induced Factor-1alpha in Thyroid Follicular Carcinoma Cells.", "journal": "PloS one", "date": "2013", "authors": "Kalhori V, Kemppainen K, Asghar MY, Bergelin N, Jaakkola P, Tornquist K", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "23824493", "url": "https://glygen.org/publication/PubMed/23824493" } ] }, { "title": "Human eIF4E promotes mRNA restructuring by stimulating eIF4A helicase activity.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2013", "authors": "Feoktistova K, Tuvshintogs E, Do A, Fraser CS", "evidence": [ { "database": "RefSeq", "id": "NP_001317946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317946" } ], "reference": [ { "type": "PubMed", "id": "23901100", "url": "https://glygen.org/publication/PubMed/23901100" } ] }, { "title": "Investigating the consequences of eIF4E2 (4EHP) interaction with 4E-transporter on its cellular distribution in HeLa cells.", "journal": "PLoS ONE", "date": "2013", "authors": "Kubacka D, Kamenska A, Broomhead H, Minshall N, Darzynkiewicz E, Standart N", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "23991149", "url": "https://glygen.org/publication/PubMed/23991149" } ] }, { "title": "Interaction of the eukaryotic initiation factor 4E with 4E-BP2 at a dynamic bipartite interface.", "journal": "Structure", "date": "2013", "authors": "Lukhele S, Bah A, Lin H, Sonenberg N, Forman-Kay JD", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "24207126", "url": "https://glygen.org/publication/PubMed/24207126" } ] }, { "title": "Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing.", "journal": "Nucleic acids research", "date": "2014", "authors": "Kamenska A, Lu WT, Kubacka D, Broomhead H, Minshall N, Bushell M, Standart N", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "24335285", "url": "https://glygen.org/publication/PubMed/24335285" } ] }, { "title": "First MNKs degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines.", "journal": "Oncotarget", "date": "2014", "authors": "Ramalingam S, Gediya L, Kwegyir-Afful AK, Ramamurthy VP, Purushottamachar P, Mbatia H, Njar VC", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "24504069", "url": "https://glygen.org/publication/PubMed/24504069" } ] }, { "title": "Phosphorylated Mnk1 and eIF4E are associated with lymph node metastasis and poor prognosis of nasopharyngeal carcinoma.", "journal": "PloS one", "date": "2014", "authors": "Zheng J, Li J, Xu L, Xie G, Wen Q, Luo J, Li D, Huang D, Fan S", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "24551240", "url": "https://glygen.org/publication/PubMed/24551240" } ] }, { "title": "Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells.", "journal": "Oncotarget", "date": "2014", "authors": "Eckerdt F, Beauchamp E, Bell J, Iqbal A, Su B, Fukunaga R, Lulla RR, Goldman S, Platanias LC", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "25193863", "url": "https://glygen.org/publication/PubMed/25193863" } ] }, { "title": "Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73.", "journal": "Oncotarget", "date": "2014", "authors": "Lam F, Abbas AY, Shao H, Teo T, Adams J, Li P, Bradshaw TD, Fischer PM, Walsby E, Pepper C, Chen Y, Ding J, Wang S", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "25277198", "url": "https://glygen.org/publication/PubMed/25277198" } ] }, { "title": "MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.", "journal": "Nature communications", "date": "2014", "authors": "Landon AL, Muniandy PA, Shetty AC, Lehrmann E, Volpon L, Houng S, Zhang Y, Dai B, Peroutka R, Mazan-Mamczarz K, Steinhardt J, Mahurkar A, Becker KG, Borden KL, Gartenhaus RB", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "25403230", "url": "https://glygen.org/publication/PubMed/25403230" } ] }, { "title": "An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program.", "journal": "Neuron", "date": "2014", "authors": "Yang G, Smibert CA, Kaplan DR, Miller FD", "evidence": [ { "database": "RefSeq", "id": "NP_001317946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317946" } ], "reference": [ { "type": "PubMed", "id": "25456498", "url": "https://glygen.org/publication/PubMed/25456498" } ] }, { "title": "Uridylation by TUT4 and TUT7 marks mRNA for degradation.", "journal": "Cell", "date": "2014", "authors": "Lim J, Ha M, Chang H, Kwon SC, Simanshu DK, Patel DJ, Kim VN", "evidence": [ { "database": "Reactome", "id": "R-HSA-429947", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-429947" } ], "reference": [ { "type": "PubMed", "id": "25480299", "url": "https://glygen.org/publication/PubMed/25480299" } ] }, { "title": "Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch.", "journal": "Nature", "date": "2015", "authors": "Bah A, Vernon RM, Siddiqui Z, Krzeminski M, Muhandiram R, Zhao C, Sonenberg N, Kay LE, Forman-Kay JD", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "25533957", "url": "https://glygen.org/publication/PubMed/25533957" } ] }, { "title": "The antileukemia roles of PP242 alone or in combination with daunorubicin in acute leukemia.", "journal": "Anti-cancer drugs", "date": "2015", "authors": "Shi F, Yang X, Gong Y, Shi R, Yang X, Naren D, Wu J", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "25535978", "url": "https://glygen.org/publication/PubMed/25535978" } ] }, { "title": "Murine norovirus 1 (MNV1) replication induces translational control of the host by regulating eIF4E activity during infection.", "journal": "The Journal of biological chemistry", "date": "2015", "authors": "Royall E, Doyle N, Abdul-Wahab A, Emmott E, Morley SJ, Goodfellow I, Roberts LO, Locker N", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "25561727", "url": "https://glygen.org/publication/PubMed/25561727" } ] }, { "title": "Molecular architecture of 4E-BP translational inhibitors bound to eIF4E.", "journal": "Mol. Cell", "date": "2015", "authors": "Peter D, Igreja C, Weber R, Wohlbold L, Weiler C, Ebertsch L, Weichenrieder O, Izaurralde E", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "25702871", "url": "https://glygen.org/publication/PubMed/25702871" } ] }, { "title": "Small-molecule induction of phospho-eIF4E sumoylation and degradation via targeting its phosphorylated serine 209 residue.", "journal": "Oncotarget", "date": "2015", "authors": "Gu Y, Zhou H, Gan Y, Zhang J, Chen J, Gan X, Li H, Zheng W, Meng Z, Ma X, Wang X, Xu X, Xu G, Lu X, Liang Y, Zhang X, Lu X, Huang W, Xu R", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "25915158", "url": "https://glygen.org/publication/PubMed/25915158" } ] }, { "title": "Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches.", "journal": "PloS one", "date": "2015", "authors": "Martinez A, Sese M, Losa JH, Robichaud N, Sonenberg N, Aasen T, Ramon Y Cajal S", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "25923732", "url": "https://glygen.org/publication/PubMed/25923732" } ] }, { "title": "Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL.", "journal": "Oncotarget", "date": "2015", "authors": "De Falco F, Sabatini R, Del Papa B, Falzetti F, Di Ianni M, Sportoletti P, Baldoni S, Screpanti I, Marconi P, Rosati E", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "26041884", "url": "https://glygen.org/publication/PubMed/26041884" } ] }, { "title": "New insights into malignant cell survival mechanisms in medulloblastoma.", "journal": "Cancer cell & microenvironment", "date": "2014", "authors": "Eckerdt F, Goldman S, Platanias LC", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "26097864", "url": "https://glygen.org/publication/PubMed/26097864" } ] }, { "title": "Identification of a Highly Conserved Allosteric Binding Site on Mnk1 and Mnk2.", "journal": "Molecular pharmacology", "date": "2015", "authors": "Basnet SK, Diab S, Schmid R, Yu M, Yang Y, Gillam TA, Teo T, Li P, Peat T, Albrecht H, Wang S", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "26268528", "url": "https://glygen.org/publication/PubMed/26268528" } ] }, { "title": "Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E Pathway.", "journal": "PLoS pathogens", "date": "2015", "authors": "Joubert PE, Stapleford K, Guivel-Benhassine F, Vignuzzi M, Schwartz O, Albert ML", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "26317997", "url": "https://glygen.org/publication/PubMed/26317997" } ] }, { "title": "Isolation of Flavonoids from Deguelia duckeana and Their Effect on Cellular Viability, AMPK, eEF2, eIF2 and eIF4E.", "journal": "Molecules (Basel, Switzerland)", "date": "2016", "authors": "Cursino LM, Lima NM, Murillo R, Nunez CV, Merfort I, Humar M", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "26861281", "url": "https://glygen.org/publication/PubMed/26861281" } ] }, { "title": "Phosphorylation of eIF4E serine 209 is associated with tumour progression and reduced survival in malignant melanoma.", "journal": "British journal of cancer", "date": "2016", "authors": "Carter JH, Deddens JA, Spaulding NR IV, Lucas D, Colligan BM, Lewis TG, Hawkins E, Jones J, Pemberton JO, Douglass LE, Graff JR", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "26882068", "url": "https://glygen.org/publication/PubMed/26882068" } ] }, { "title": "The m(6)A methyltransferase METTL3 promotes translation in human cancer cells.", "journal": "Mol. Cell", "date": "2016", "authors": "Lin S, Choe J, Du P, Triboulet R, Gregory RI", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "27117702", "url": "https://glygen.org/publication/PubMed/27117702" } ] }, { "title": "Adaptations to chronic rapamycin in mice.", "journal": "Pathobiology of aging & age related diseases", "date": "2016", "authors": "Dodds SG, Livi CB, Parihar M, Hsu HK, Benavides AD, Morris J, Javors M, Strong R, Christy B, Hasty P, Sharp ZD", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "27237224", "url": "https://glygen.org/publication/PubMed/27237224" } ] }, { "title": "Inhibition of Mnk enhances apoptotic activity of cytarabine in acute myeloid leukemia cells.", "journal": "Oncotarget", "date": "2016", "authors": "Li P, Diab S, Yu M, Adams J, Islam S, Basnet SK, Albrecht H, Milne R, Wang S", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "27462781", "url": "https://glygen.org/publication/PubMed/27462781" } ] }, { "title": "Inhibiting the MNK-eIF4E-beta-catenin axis increases the responsiveness of aggressive breast cancer cells to chemotherapy.", "journal": "Oncotarget", "date": "2017", "authors": "Li Z, Sun Y, Qu M, Wan H, Cai F, Zhang P", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "27926520", "url": "https://glygen.org/publication/PubMed/27926520" } ] }, { "title": "A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery.", "journal": "RNA", "date": "2017", "authors": "Volpon Laurent, Culjkovic-Kraljacic Biljana, Sohn Hye Seon, Blanchet-Cohen Alexis, Osborne Michael J, Borden Katherine L B", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "28325843", "url": "https://glygen.org/publication/PubMed/28325843" } ] }, { "title": "Targeting the eIF4E/beta-catenin axis sensitizes cervical carcinoma squamous cells to chemotherapy.", "journal": "American journal of translational research", "date": "2017", "authors": "Xu H, Wang Z, Xu L, Mo G, Duan G, Wang Y, Sun Z, Chen H", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "28386346", "url": "https://glygen.org/publication/PubMed/28386346" } ] }, { "title": "Cap-binding protein 4EHP effects translation silencing by microRNAs.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2017", "authors": "Chapat C, Jafarnejad SM, Matta-Camacho E, Hesketh GG, Gelbart IA, Attig J, Gkogkas CG, Alain T, Stern-Ginossar N, Fabian MR, Gingras AC, Duchaine TF, Sonenberg N", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "28487484", "url": "https://glygen.org/publication/PubMed/28487484" } ] }, { "title": "The helicase, DDX3X, interacts with poly(A)-binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading.", "journal": "Biochem. J.", "date": "2017", "authors": "Copsey AC, Cooper S, Parker R, Lineham E, Lapworth C, Jallad D, Sweet S, Morley SJ", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "28733330", "url": "https://glygen.org/publication/PubMed/28733330" } ] }, { "title": "The androgen receptor is a negative regulator of eIF4E phosphorylation at S209: implications for the use of mTOR inhibitors in advanced prostate cancer.", "journal": "Oncogene", "date": "2017", "authors": "D'Abronzo LS, Bose S, Crapuchettes ME, Beggs RE, Vinall RL, Tepper CG, Siddiqui S, Mudryj M, Melgoza FU, Durbin-Johnson BP, deVere White RW, Ghosh PM", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "28745319", "url": "https://glygen.org/publication/PubMed/28745319" } ] }, { "title": "Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1979", "authors": "Sonenberg N, Rupprecht KM, Hecht SM, Shatkin AJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-72662", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72662" } ], "reference": [ { "type": "PubMed", "id": "291969", "url": "https://glygen.org/publication/PubMed/291969" } ] }, { "title": "Hyperactive mTOR and MNK1 phosphorylation of eIF4E confer tamoxifen resistance and estrogen independence through selective mRNA translation reprogramming.", "journal": "Genes & development", "date": "2017", "authors": "Geter PA, Ernlund AW, Bakogianni S, Alard A, Arju R, Giashuddin S, Gadi A, Bromberg J, Schneider RJ", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "29269484", "url": "https://glygen.org/publication/PubMed/29269484" } ] }, { "title": "Rbm24, a target of p53, is necessary for proper expression of p53 and heart development.", "journal": "Cell Death Differ.", "date": "2018", "authors": "Zhang M, Zhang Y, Xu E, Mohibi S, de Anda DM, Jiang Y, Zhang J, Chen X", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "29358667", "url": "https://glygen.org/publication/PubMed/29358667" } ] }, { "title": "Synergistic effects of inhibiting the MNK-eIF4E and PI3K/AKT/ mTOR pathways on cell migration in MDA-MB-231 cells.", "journal": "Oncotarget", "date": "2018", "authors": "Lineham E, Tizzard GJ, Coles SJ, Spencer J, Morley SJ", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "29581834", "url": "https://glygen.org/publication/PubMed/29581834" } ] }, { "title": "Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia.", "journal": "Journal of medicinal chemistry", "date": "2018", "authors": "Yang H, Chennamaneni LR, Ho MWT, Ang SH, Tan ESW, Jeyaraj DA, Yeap YS, Liu B, Ong EH, Joy JK, Wee JLK, Kwek P, Retna P, Dinie N, Nguyen TTH, Tai SJ, Manoharan V, Pendharkar V, Low CB, Chew YS, Vuddagiri S, Sangthongpitag K, Choong ML, Lee MA, Kannan S, Verma CS, Poulsen A, Lim S, Chuah C, Ong TS, Hill J, Matter A, Nacro K", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "29683667", "url": "https://glygen.org/publication/PubMed/29683667" } ] }, { "title": "Dynamic Interaction of Eukaryotic Initiation Factor 4G1 (eIF4G1) with eIF4E and eIF1 Underlies Scanning-Dependent and -Independent Translation.", "journal": "Molecular and cellular biology", "date": "2018", "authors": "Haimov O, Sehrawat U, Tamarkin-Ben Harush A, Bahat A, Uzonyi A, Will A, Hiraishi H, Asano K, Dikstein R", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "29987188", "url": "https://glygen.org/publication/PubMed/29987188" } ] }, { "title": "The Natural Compound Homoharringtonine Presents Broad Antiviral Activity In Vitro and In Vivo.", "journal": "Viruses", "date": "2018", "authors": "Dong HJ, Wang ZH, Meng W, Li CC, Hu YX, Zhou L, Wang XJ", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "30388805", "url": "https://glygen.org/publication/PubMed/30388805" } ] }, { "title": "O-GlcNAc transferase activates stem-like cell potential in hepatocarcinoma through O-GlcNAcylation of eukaryotic initiation factor 4E.", "journal": "Journal of cellular and molecular medicine", "date": "2019", "authors": "Cao B, Duan M, Xing Y, Liu C, Yang F, Li Y, Yang T, Wei Y, Gao Q, Jiang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "P06730", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P06730" }, { "database": "O-GlcNAc Atlas", "id": "P06730", "url": "https://oglcnac.org/atlas/detail/P06730" } ], "reference": [ { "type": "PubMed", "id": "30677218", "url": "https://glygen.org/publication/PubMed/30677218" } ] }, { "title": "Nuclear eIF4E Stimulates 3'-End Cleavage of Target RNAs.", "journal": "Cell Rep.", "date": "2019", "authors": "Davis Margaret Rose, Delaleau Mildred, Borden Katherine L B", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "31042468", "url": "https://glygen.org/publication/PubMed/31042468" } ] }, { "title": "XPO1 inhibitor KPT-330 synergizes with Bcl-xL inhibitor to induce cancer cell apoptosis by perturbing rRNA processing and Mcl-1 protein synthesis.", "journal": "Cell death & disease", "date": "2019-05-21", "authors": "Zhu Zhi-Chuan, Liu Ji-Wei, Yang Can, Zhao Miao, Xiong Zhi-Qi", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "31113936", "url": "https://glygen.org/publication/PubMed/31113936" } ] }, { "title": "Monitoring flux in signalling pathways through measurements of 4EBP1-mediated eIF4F complex assembly.", "journal": "BMC biology", "date": "2019", "authors": "Frosi Y, Usher R, Lian DTG, Lane DP, Brown CJ", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "31118010", "url": "https://glygen.org/publication/PubMed/31118010" } ] }, { "title": "Phosphorylation site of eukaryotic initiation factor 4E.", "journal": "The Journal of biological chemistry", "date": "1987", "authors": "Rychlik W, Russ MA, Rhoads RE", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "iPTMnet", "id": "P06730-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730-1" } ], "reference": [ { "type": "PubMed", "id": "3112145", "url": "https://glygen.org/publication/PubMed/3112145" } ] }, { "title": "Impact of eIF4E phosphorylation at Ser209 via MNK2a on tumour recurrence after curative surgery in localized clear cell renal cell carcinoma.", "journal": "Oncotarget", "date": "2019", "authors": "Ichiyanagi O, Ito H, Naito S, Kabasawa T, Kanno H, Narisawa T, Ushijima M, Kurota Y, Ozawa M, Sakurai T, Nishida H, Kato T, Yamakawa M, Tsuchiya N", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "31258849", "url": "https://glygen.org/publication/PubMed/31258849" } ] }, { "title": "Targeting CDK9 for treatment of colorectal cancer.", "journal": "Molecular oncology", "date": "2019", "authors": "Rahaman MH, Lam F, Zhong L, Teo T, Adams J, Yu M, Milne RW, Pepper C, Lokman NA, Ricciardelli C, Oehler MK, Wang S", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "31398271", "url": "https://glygen.org/publication/PubMed/31398271" } ] }, { "title": "Structural studies of the eIF4E-VPg complex reveal a direct competition for capped RNA: Implications for translation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2019", "authors": "Coutinho de Oliveira L, Volpon L, Rahardjo AK, Osborne MJ, Culjkovic-Kraljacic B, Trahan C, Oeffinger M, Kwok BH, Borden KLB", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "31712417", "url": "https://glygen.org/publication/PubMed/31712417" } ] }, { "title": "Inhibitory effects of SEL201 in acute myeloid leukemia.", "journal": "Oncotarget", "date": "2019-12-24", "authors": "Kosciuczuk Ewa M, Kar Aroop K, Blyth Gavin T, Fischietti Mariafausta, Abedin Sameem, Mina Alain A, Siliezar Rebekah, Rzymski Tomasz, Brzozka Krzysztof, Eklund Elizabeth A, Beauchamp Elspeth M, Eckerdt Frank, Saleiro Diana, Platanias Leonidas C", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "31903169", "url": "https://glygen.org/publication/PubMed/31903169" } ] }, { "title": "EIF4E regulates STEAP1 expression in peritoneal metastasis.", "journal": "Journal of Cancer", "date": "2020", "authors": "Jiang Jun-Nan, Wu Yuan-Yu, Fang Xue-Dong, Ji Fu-Jian", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "31949502", "url": "https://glygen.org/publication/PubMed/31949502" } ] }, { "title": "Homozygous Mutations in BTG4 Cause Zygotic Cleavage Failure and Female Infertility.", "journal": "American journal of human genetics", "date": "2020", "authors": "Zheng W, Zhou Z, Sha Q, Niu X, Sun X, Shi J, Zhao L, Zhang S, Dai J, Cai S, Meng F, Hu L, Gong F, Li X, Fu J, Shi R, Lu G, Chen B, Fan H, Wang L, Lin G, Sang Q", "evidence": [ { "database": "Reactome", "id": "R-HSA-9820841", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9820841" } ], "reference": [ { "type": "PubMed", "id": "32502391", "url": "https://glygen.org/publication/PubMed/32502391" } ] }, { "title": "Phosphorylation of the mRNA cap-binding protein eIF4E and cancer.", "journal": "Cellular signalling", "date": "2020-09", "authors": "Yang Xiaotong, Zhong Wu, Cao Ruifeng", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "32535199", "url": "https://glygen.org/publication/PubMed/32535199" } ] }, { "title": "Infection by the Protozoan Parasite Toxoplasma gondii Inhibits Host MNK1/2-eIF4E Axis to Promote Its Survival.", "journal": "Frontiers in cellular and infection microbiology", "date": "2020", "authors": "Leroux Louis-Philippe, Chaparro Visnu, Jaramillo Maritza", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "33014898", "url": "https://glygen.org/publication/PubMed/33014898" } ] }, { "title": "Contribution of miRNAs, tRNAs and tRFs to Aberrant Signaling and Translation Deregulation in Lung Cancer.", "journal": "Cancers", "date": "2020-10-20", "authors": "Skeparnias Ilias, Anastasakis Dimitrios, Grafanaki Katerina, Kyriakopoulos George, Alexopoulos Panagiotis, Dougenis Dimitrios, Scorilas Andreas, Kontos Christos K, Stathopoulos Constantinos", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "33092114", "url": "https://glygen.org/publication/PubMed/33092114" } ] }, { "title": "Indole hydrazide compound ZJQ-24 inhibits angiogenesis and induces apoptosis cell death through abrogation of AKT/mTOR pathway in hepatocellular carcinoma.", "journal": "Cell death & disease", "date": "2020-10-28", "authors": "Liu Jing, Liu Ying, Zhang Jianqiang, Liu Dan, Bao Yafeng, Chen Tianxing, Tang Tao, Lin Jun, Luo Ying, Jin Yi, Zhang Jihong", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "33116125", "url": "https://glygen.org/publication/PubMed/33116125" } ] }, { "title": "Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect.", "journal": "ACS chemical biology", "date": "2021-02-19", "authors": "Warminski Marcin, Kowalska Joanna, Nowak Elzbieta, Kubacka Dorota, Tibble Ryan, Kasprzyk Renata, Sikorski Pawel J, Gross John D, Nowotny Marcin, Jemielity Jacek", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "33439620", "url": "https://glygen.org/publication/PubMed/33439620" } ] }, { "title": "Design, synthesis and biological evaluation of imidazopyridazine derivatives containing isoquinoline group as potent MNK1/2 inhibitors.", "journal": "Bioorganic & medicinal chemistry", "date": "2021-06-15", "authors": "Bu Hong, Yuan Xinrui, Wu Hanshu, Zhou Jinpei, Zhang Huibin", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "33971490", "url": "https://glygen.org/publication/PubMed/33971490" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "P06730", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P06730" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "A novel homozygous missense variant in BTG4 causes zygotic cleavage failure and female infertility.", "journal": "Journal of assisted reproduction and genetics", "date": "2021", "authors": "Liu R, Zhou Y, Li Q, Chen B, Zhou Z, Wang L, Wang L, Sang Q, Jin L", "evidence": [ { "database": "Reactome", "id": "R-HSA-9820841", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9820841" } ], "reference": [ { "type": "PubMed", "id": "34647228", "url": "https://glygen.org/publication/PubMed/34647228" } ] }, { "title": "Amino acid sequence of the mRNA cap-binding protein from human tissues.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1987", "authors": "Rychlik W, Domier LL, Gardner PR, Hellmann GM, Rhoads RE", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "3469651", "url": "https://glygen.org/publication/PubMed/3469651" } ] }, { "title": "Truncation of the TPR domain of OGT alters substrate and glycosite selection.", "journal": "Analytical and bioanalytical chemistry", "date": "2021", "authors": "Ramirez DH, Yang B, D'Souza AK, Shen D, Woo CM", "evidence": [ { "database": "O-GlcNAc Database", "id": "P06730", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P06730" } ], "reference": [ { "type": "PubMed", "id": "34725712", "url": "https://glygen.org/publication/PubMed/34725712" } ] }, { "title": "The eukaryotic translation initiation factor eIF4E reprograms alternative splicing.", "journal": "EMBO J.", "date": "2023", "authors": "Ghram Mehdi, Morris Gavin, Culjkovic-Kraljacic Biljana, Mars Jean-Clement, Gendron Patrick, Skrabanek Lucy, Revuelta Maria Victoria, Cerchietti Leandro, Guzman Monica L, Borden Katherine L B", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "36843541", "url": "https://glygen.org/publication/PubMed/36843541" } ] }, { "title": "Genetic Evidence Supporting a Causal Association Between mTOR-Dependent EIF-4E Circulating Protein Level and Osteoporosis.", "journal": "Advances in therapy", "date": "2023-11", "authors": "Cheng Ting, Zhang Yao-Chen, Fan Ke-Yi, Hu Jing-Xi, Wang Qian, Wang Qi, Liu Liu, Zhang He-Yi, Hou Yao-Pu, Li Xiao-Feng, Zhang Sheng-Xiao", "evidence": [ { "database": "RefSeq", "id": "NP_001317946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317946" } ], "reference": [ { "type": "PubMed", "id": "37728694", "url": "https://glygen.org/publication/PubMed/37728694" } ] }, { "title": "The eukaryotic translation initiation factor eIF4E unexpectedly acts in splicing thereby coupling mRNA processing with translation: eIF4E induces widescale splicing reprogramming providing system-wide connectivity between splicing, nuclear mRNA export and translation.", "journal": "BioEssays : news and reviews in molecular, cellular and developmental biology", "date": "2024-01", "authors": "Borden Katherine L B", "evidence": [ { "database": "RefSeq", "id": "NP_001317946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317946" } ], "reference": [ { "type": "PubMed", "id": "37926700", "url": "https://glygen.org/publication/PubMed/37926700" } ] }, { "title": "Binding and release of radiolabeled eukaryotic initiation factors 2 and 3 during 80 S initiation complex formation.", "journal": "The Journal of biological chemistry", "date": "1979", "authors": "Peterson DT, Merrick WC, Safer B", "evidence": [ { "database": "Reactome", "id": "R-HSA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72706" } ], "reference": [ { "type": "PubMed", "id": "429297", "url": "https://glygen.org/publication/PubMed/429297" } ] }, { "title": "Initiation of mammalian protein synthesis. I. Purification and characterization of seven initiation factors.", "journal": "Journal of molecular biology", "date": "1977", "authors": "Schreier MH, Erni B, Staehelin T", "evidence": [ { "database": "Reactome", "id": "R-HSA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72706" } ], "reference": [ { "type": "PubMed", "id": "592398", "url": "https://glygen.org/publication/PubMed/592398" } ] }, { "title": "Initiation of mammalian protein synthesis. II. The assembly of the initiation complex with purified initiation factors.", "journal": "Journal of molecular biology", "date": "1977", "authors": "Trachsel H, Erni B, Schreier MH, Staehelin T", "evidence": [ { "database": "Reactome", "id": "R-HSA-72649", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72649" } ], "reference": [ { "type": "PubMed", "id": "592399", "url": "https://glygen.org/publication/PubMed/592399" } ] }, { "title": "The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes.", "journal": "The Journal of biological chemistry", "date": "1978", "authors": "Benne R, Hershey JW", "evidence": [ { "database": "Reactome", "id": "R-HSA-72649", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72649" } ], "reference": [ { "type": "PubMed", "id": "641056", "url": "https://glygen.org/publication/PubMed/641056" } ] }, { "title": "New initiation factor activity required for globin mRNA translation.", "journal": "The Journal of biological chemistry", "date": "1983", "authors": "Grifo JA, Tahara SM, Morgan MA, Shatkin AJ, Merrick WC", "evidence": [ { "database": "Reactome", "id": "R-HSA-72649", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72649" } ], "reference": [ { "type": "PubMed", "id": "6853548", "url": "https://glygen.org/publication/PubMed/6853548" } ] }, { "title": "Evaluation of the `scanning model` for initiation of protein synthesis in eucaryotes.", "journal": "Cell", "date": "1980", "authors": "Kozak M", "evidence": [ { "database": "Reactome", "id": "R-HSA-72702", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72702" } ], "reference": [ { "type": "PubMed", "id": "7000367", "url": "https://glygen.org/publication/PubMed/7000367" } ] }, { "title": "Nuclear import of influenza virus RNA can be mediated by viral nucleoprotein and transport factors required for protein import.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "O'Neill RE, Jaskunas R, Blobel G, Palese P, Moroianu J", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "7559393", "url": "https://glygen.org/publication/PubMed/7559393" } ] }, { "title": "Role of Ser-53 phosphorylation in the activity of human translation initiation factor eIF-4E in mammalian and yeast cells.", "journal": "Gene", "date": "1995", "authors": "Zhang Y, Klein HL, Schneider RJ", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "7590282", "url": "https://glygen.org/publication/PubMed/7590282" } ] }, { "title": "Serine 209, not serine 53, is the major site of phosphorylation in initiation factor eIF-4E in serum-treated Chinese hamster ovary cells.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "Flynn A, Proud CG", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "7665584", "url": "https://glygen.org/publication/PubMed/7665584" } ] }, { "title": "Phosphorylation of eukaryotic protein synthesis initiation factor 4E at Ser-209.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "Joshi B, Cai AL, Keiper BD, Minich WB, Mendez R, Beach CM, Stepinski J, Stolarski R, Darzynkiewicz E, Rhoads RE", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "7782323", "url": "https://glygen.org/publication/PubMed/7782323" } ] }, { "title": "Phosphorylation of eukaryotic protein synthesis initiation factor 4E by insulin-stimulated protamine kinase.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "Makkinje A, Xiong H, Li M, Damuni Z", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "7782349", "url": "https://glygen.org/publication/PubMed/7782349" } ] }, { "title": "Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function.", "journal": "Nature", "date": "1994", "authors": "Pause A, Belsham GJ, Gingras AC, Donze O, Lin TA, Lawrence JC Jr, Sonenberg N", "evidence": [ { "database": "Reactome", "id": "R-HSA-72662", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72662" } ], "reference": [ { "type": "PubMed", "id": "7935836", "url": "https://glygen.org/publication/PubMed/7935836" } ] }, { "title": "The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A.", "journal": "The Journal of biological chemistry", "date": "1993", "authors": "Yoder-Hill J, Pause A, Sonenberg N, Merrick WC", "evidence": [ { "database": "Reactome", "id": "R-HSA-72662", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72662" } ], "reference": [ { "type": "PubMed", "id": "8449919", "url": "https://glygen.org/publication/PubMed/8449919" } ] }, { "title": "Characterization of wild-type and Ser53 mutant eukaryotic initiation factor 4E overexpression in mammalian cells.", "journal": "The Journal of biological chemistry", "date": "1993", "authors": "Kaufman RJ, Murtha-Riel P, Pittman DD, Davies MV", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "8505316", "url": "https://glygen.org/publication/PubMed/8505316" } ] }, { "title": "Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.", "journal": "EMBO J.", "date": "1995", "authors": "Haghighat A, Mader S, Pause A, Sonenberg N", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "reference": [ { "type": "PubMed", "id": "8521827", "url": "https://glygen.org/publication/PubMed/8521827" } ] }, { "title": "Phosphorylation of eIF-4E on serine 209 by protein kinase C is inhibited by the translational repressors, 4E-binding proteins.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Whalen SG, Gingras AC, Amankwa L, Mader S, Branton PE, Aebersold R, Sonenberg N", "evidence": [ { "database": "iPTMnet", "id": "P06730-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730-1" } ], "reference": [ { "type": "PubMed", "id": "8662663", "url": "https://glygen.org/publication/PubMed/8662663" } ] }, { "title": "Functional dissection of eukaryotic initiation factor 4F: the 4A subunit and the central domain of the 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes.", "journal": "Molecular and cellular biology", "date": "1996", "authors": "Pestova TV, Shatsky IN, Hellen CU", "evidence": [ { "database": "Reactome", "id": "R-HSA-72702", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72702" } ], "reference": [ { "type": "PubMed", "id": "8943342", "url": "https://glygen.org/publication/PubMed/8943342" } ] }, { "title": "Requirement of the DEAD-Box protein ded1p for messenger RNA translation.", "journal": "Science (New York, N.Y.)", "date": "1997", "authors": "Chuang RY, Weaver PL, Liu Z, Chang TH", "evidence": [ { "database": "Reactome", "id": "R-HSA-72702", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72702" } ], "reference": [ { "type": "PubMed", "id": "9045610", "url": "https://glygen.org/publication/PubMed/9045610" } ] }, { "title": "Poly(A) tail shortening by a mammalian poly(A)-specific 3'-exoribonuclease.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Korner CG, Wahle E", "evidence": [ { "database": "Reactome", "id": "R-HSA-429947", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-429947" } ], "reference": [ { "type": "PubMed", "id": "9099687", "url": "https://glygen.org/publication/PubMed/9099687" } ] }, { "title": "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2.", "journal": "The EMBO journal", "date": "1997", "authors": "Waskiewicz AJ, Flynn A, Proud CG, Cooper JA", "evidence": [ { "database": "iPTMnet", "id": "P06730-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730-1" } ], "reference": [ { "type": "PubMed", "id": "9155017", "url": "https://glygen.org/publication/PubMed/9155017" } ] }, { "title": "Ubiquitin is covalently attached to the p6Gag proteins of human immunodeficiency virus type 1 and simian immunodeficiency virus and to the p12Gag protein of Moloney murine leukemia virus.", "journal": "Journal of virology", "date": "1998", "authors": "Ott DE, Coren LV, Copeland TD, Kane BP, Johnson DG, Sowder RC 2nd, Yoshinaka Y, Oroszlan S, Arthur LO, Henderson LE", "evidence": [ { "database": "Reactome", "id": "R-HSA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408" } ], "reference": [ { "type": "PubMed", "id": "9525617", "url": "https://glygen.org/publication/PubMed/9525617" } ] }, { "title": "Effect of mRNA cap structure on eIF-4E phosphorylation and cap binding analyses using Ser209-mutated eIF-4Es.", "journal": "Biochemical and biophysical research communications", "date": "1998", "authors": "Shibata S, Morino S, Tomoo K, In Y, Ishida T", "evidence": [ { "database": "iPTMnet", "id": "P06730", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730" } ], "reference": [ { "type": "PubMed", "id": "9642105", "url": "https://glygen.org/publication/PubMed/9642105" } ] }, { "title": "Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression.", "journal": "Clinical biochemistry", "date": "1998", "authors": "Sehgal SN", "evidence": [ { "database": "Reactome", "id": "R-HSA-166208", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166208" } ], "reference": [ { "type": "PubMed", "id": "9721431", "url": "https://glygen.org/publication/PubMed/9721431" } ] }, { "title": "Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons.", "journal": "Nature", "date": "1998", "authors": "Pestova TV, Borukhov SI, Hellen CU", "evidence": [ { "database": "Reactome", "id": "R-HSA-72649", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72649" } ], "reference": [ { "type": "PubMed", "id": "9732867", "url": "https://glygen.org/publication/PubMed/9732867" } ] }, { "title": "A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation.", "journal": "The EMBO journal", "date": "1998", "authors": "Imataka H, Gradi A, Sonenberg N", "evidence": [ { "database": "Reactome", "id": "R-HSA-72649", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72649" } ], "reference": [ { "type": "PubMed", "id": "9857202", "url": "https://glygen.org/publication/PubMed/9857202" } ] }, { "title": "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.", "journal": "The EMBO journal", "date": "1999", "authors": "Pyronnet S, Imataka H, Gingras AC, Fukunaga R, Hunter T, Sonenberg N", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "iPTMnet", "id": "P06730-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06730-1" } ], "reference": [ { "type": "PubMed", "id": "9878069", "url": "https://glygen.org/publication/PubMed/9878069" } ] } ], "pathway": [ { "id": "hsa:1977", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:1977", "resource": "KEGG Pathway" }, { "id": "R-HSA-1169408", "name": "ISG15 antiviral mechanism", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1169408", "resource": "Reactome", "description": "ISG15 antiviral mechanism" }, { "id": "R-HSA-156827", "name": "L13a-mediated translational silencing of Ceruloplasmin expression", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-HSA-159227", "name": "Transport of the SLBP independent Mature mRNA", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159227", "resource": "Reactome", "description": "Transport of the SLBP independent Mature mRNA" }, { "id": "R-HSA-159230", "name": "Transport of the SLBP Dependant Mature mRNA", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159230", "resource": "Reactome", "description": "Transport of the SLBP Dependant Mature mRNA" }, { "id": "R-HSA-159231", "name": "Transport of Mature mRNA Derived from an Intronless Transcript", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159231", "resource": "Reactome", "description": "Transport of Mature mRNA Derived from an Intronless Transcript" }, { "id": "R-HSA-166208", "name": "mTORC1-mediated signalling", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166208", "resource": "Reactome", "description": "mTORC1-mediated signalling" }, { "id": "R-HSA-429947", "name": "Deadenylation of mRNA", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-429947", "resource": "Reactome", "description": "Deadenylation of mRNA" }, { "id": "R-HSA-72649", "name": "Translation initiation complex formation", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72649", "resource": "Reactome", "description": "Translation initiation complex formation" }, { "id": "R-HSA-72662", "name": "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72662", "resource": "Reactome", "description": "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S" }, { "id": "R-HSA-72702", "name": "Ribosomal scanning and start codon recognition", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72702", "resource": "Reactome", "description": "Ribosomal scanning and start codon recognition" }, { "id": "R-HSA-72706", "name": "GTP hydrolysis and joining of the 60S ribosomal subunit", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-HSA-9820841", "name": "M-decay: degradation of maternal mRNAs by maternally stored factors", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9820841", "resource": "Reactome", "description": "M-decay: degradation of maternal mRNAs by maternally stored factors" }, { "id": "R-HSA-9820865", "name": "Z-decay: degradation of maternal mRNAs by zygotically expressed factors", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9820865", "resource": "Reactome", "description": "Z-decay: degradation of maternal mRNAs by zygotically expressed factors" } ], "orthologs": [ { "uniprot_canonical_ac": "P63073-1", "protein_name": "Eukaryotic translation initiation factor 4E", "gene_name": "Eif4e", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATVEPETTPTTNPPPAEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENRDAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV", "length": 217 }, "evidence": [ { "id": "45918320", "url": "http://www.informatics.jax.org/homology/45918320", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P63074-1", "protein_name": "Eukaryotic translation initiation factor 4E", "gene_name": "Eif4e", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATVEPETTPTTNPPPAEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENRDAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV", "length": 217 }, "evidence": [ { "id": "45918320", "url": "http://www.informatics.jax.org/homology/45918320", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 15, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "postsynapse", "id": "GO:0098794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098794", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "P-body", "id": "GO:0000932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000932", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "eukaryotic translation initiation factor 4F complex", "id": "GO:0016281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016281", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "cytoplasmic ribonucleoprotein granule", "id": "GO:0036464", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036464", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "RISC complex", "id": "GO:0016442", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016442", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "mRNA cap binding complex", "id": "GO:0005845", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005845", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "cytoplasmic stress granule", "id": "GO:0010494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010494", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "chromatoid body", "id": "GO:0033391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033391", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "RNA 7-methylguanosine cap binding", "id": "GO:0000340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000340", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "translation initiation factor activity", "id": "GO:0003743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003743", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "mRNA cap binding", "id": "GO:0098808", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098808", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "RNA cap binding", "id": "GO:0000339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000339", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "eukaryotic initiation factor 4G binding", "id": "GO:0031370", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031370", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "DNA-binding transcription factor binding", "id": "GO:0140297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140297", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "mRNA export from nucleus", "id": "GO:0006406", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006406", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "regulation of translation", "id": "GO:0006417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006417", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "negative regulation of neuron differentiation", "id": "GO:0045665", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045665", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "positive regulation of mitotic cell cycle", "id": "GO:0045931", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045931", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "translational initiation", "id": "GO:0006413", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006413", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "neuron differentiation", "id": "GO:0030182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030182", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "cellular response to dexamethasone stimulus", "id": "GO:0071549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071549", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "behavioral fear response", "id": "GO:0001662", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001662", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "G1/S transition of mitotic cell cycle", "id": "GO:0000082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000082", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "negative regulation of translation", "id": "GO:0017148", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017148", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "stem cell population maintenance", "id": "GO:0019827", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019827", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" }, { "name": "regulation of translation at postsynapse, modulating synaptic transmission", "id": "GO:0099578", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099578", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [ { "annotation": "Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex (PubMed:11154262, PubMed:3112145, PubMed:7590282, PubMed:7665584, PubMed:7782323, PubMed:8505316, PubMed:9878069). Phosphorylation also enhances its mRNA transport function (By similarity). Phosphorylation at Ser-209 is not essential for protein synthesis (PubMed:11606200, PubMed:12138083).", "evidence": [ { "database": "UniProtKB", "id": "P06730", "url": "https://www.uniprot.org/uniprot/P06730" }, { "database": "PubMed", "id": "7665584", "url": "https://glygen.org/publication/PubMed/7665584" }, { "database": "PubMed", "id": "9878069", "url": "https://glygen.org/publication/PubMed/9878069" }, { "database": "PubMed", "id": "7782323", "url": "https://glygen.org/publication/PubMed/7782323" }, { "database": "PubMed", "id": "3112145", "url": "https://glygen.org/publication/PubMed/3112145" }, { "database": "PubMed", "id": "11154262", "url": "https://glygen.org/publication/PubMed/11154262" }, { "database": "PubMed", "id": "8505316", "url": "https://glygen.org/publication/PubMed/8505316" }, { "database": "PubMed", "id": "7590282", "url": "https://glygen.org/publication/PubMed/7590282" }, { "database": "PubMed", "id": "11606200", "url": "https://glygen.org/publication/PubMed/11606200" }, { "database": "PubMed", "id": "12138083", "url": "https://glygen.org/publication/PubMed/12138083" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 168, 177 ], "snv_sites": [ 79, 177 ], "glycation_sites": [], "phosphorylation_sites": [ 9, 22, 53, 207, 209, 210 ], "sequon_annotation_sites": [] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 12 }, { "field": "total_sites", "count": 6 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 234 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }