{ "uniprot_canonical_ac": "P06493-1", "uniprot_ac": "P06493", "uniprot_id": "CDK1_HUMAN", "mass": { "chemical_mass": 34095.0, "monoisotopic_mass": 34095.0 }, "refseq": { "ac": "NP_001307847", "name": "cyclin-dependent kinase 1 isoform 1", "summary": "The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2023].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307847" }, "gene_names": [ { "name": "CDK1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P06493", "id": "P06493" }, { "name": "CDC28A", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P06493", "id": "P06493" }, { "name": "CDC2; CDC28A; P34CDC2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307847", "id": "NP_001307847" }, { "name": "CDC2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P06493", "id": "P06493" }, { "name": "CDK1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307847", "id": "NP_001307847" }, { "name": "CDKN1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P06493", "id": "P06493" }, { "name": "P34CDC2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P06493", "id": "P06493" } ], "protein_names": [ { "name": "Cyclin-dependent kinase 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P06493" }, { "name": "2.7.11.22", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P06493" }, { "name": "2.7.11.23", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P06493" }, { "name": "CDK1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P06493" }, { "name": "Cell division control protein 2 homolog", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P06493" }, { "name": "Cell division protein kinase 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P06493" }, { "name": "cell division cycle 2, G1 to S and G2 to M; cell division control protein 2 homolog; p34 protein kinase; cell cycle controller CDC2; cell division protein kinase 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307847", "id": "NP_001307847" }, { "name": "cyclin-dependent kinase 1 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307847", "id": "NP_001307847" }, { "name": "p34 protein kinase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P06493" } ], "function": [ { "annotation": "(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry.", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493#function" }, { "database": "PubMed", "id": "21516087", "url": "https://glygen.org/publication/PubMed/21516087" } ] }, { "annotation": "Deubiquitylase YOD1 regulates CDK1 stability and drives triple-negative breast cancer tumorigenesis. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001307847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307847" }, { "database": "PubMed", "id": "37667382", "url": "https://glygen.org/publication/PubMed/37667382" } ] }, { "annotation": "Dynamic phosphorylation of CENP-N by CDK1 guides accurate chromosome segregation in mitosis.", "evidence": [ { "database": "RefSeq", "id": "NP_001307847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307847" }, { "database": "PubMed", "id": "37365681", "url": "https://glygen.org/publication/PubMed/37365681" } ] }, { "annotation": "Inhibition of CDK1 Overcomes Oxaliplatin Resistance by Regulating ACSL4-mediated Ferroptosis in Colorectal Cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_001307847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307847" }, { "database": "PubMed", "id": "37428466", "url": "https://glygen.org/publication/PubMed/37428466" } ] }, { "annotation": "Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins (PubMed:16407259, PubMed:17459720, PubMed:16933150, PubMed:18356527, PubMed:19509060, PubMed:20171170, PubMed:19917720, PubMed:20937773, PubMed:20935635, PubMed:21063390, PubMed:23355470, PubMed:23601106, PubMed:23602554, PubMed:25556658, PubMed:26829474, PubMed:30704899). Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, KAT5, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MLST8, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2, CGAS and RUNX2 (PubMed:16407259, PubMed:17459720, PubMed:16933150, PubMed:18356527, PubMed:19509060, PubMed:20171170, PubMed:19917720, PubMed:20937773, PubMed:20935635, PubMed:21063390, PubMed:23355470, PubMed:23601106, PubMed:23602554, PubMed:25556658, PubMed:32351706, PubMed:26829474, PubMed:30704899, PubMed:34741373). CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs (PubMed:18480403, PubMed:20360007). Essential for early stages of embryonic development (PubMed:18480403, PubMed:20360007). During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation (PubMed:18480403, PubMed:20360007). Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis (PubMed:18480403, PubMed:20360007). Phosphorylates KRT5 during prometaphase and metaphase (By similarity). Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair (PubMed:20360007). Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression (PubMed:20395957). In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons (PubMed:18356527). The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis (PubMed:16371510). NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis (PubMed:20171170). The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis (PubMed:19917720). In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis (PubMed:20937773). This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes (PubMed:20937773). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (PubMed:20935635). CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity). CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230). Regulates the amplitude of the cyclic expression of the core clock gene BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1 (PubMed:27238018). Phosphorylates EML3 at 'Thr-881' which is essential for its interaction with HAUS augmin-like complex and TUBG1 (PubMed:30723163). Phosphorylates CGAS during mitosis, leading to its inhibition, thereby preventing CGAS activation by self DNA during mitosis (PubMed:32351706).", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493#function" }, { "database": "UniProtKB", "id": "P11440", "url": "https://www.uniprot.org/uniprot/P11440#function" }, { "database": "PubMed", "id": "20395957", "url": "https://glygen.org/publication/PubMed/20395957" }, { "database": "PubMed", "id": "17459720", "url": "https://glygen.org/publication/PubMed/17459720" }, { "database": "PubMed", "id": "26549230", "url": "https://glygen.org/publication/PubMed/26549230" }, { "database": "PubMed", "id": "18356527", "url": "https://glygen.org/publication/PubMed/18356527" }, { "database": "PubMed", "id": "25556658", "url": "https://glygen.org/publication/PubMed/25556658" }, { "database": "PubMed", "id": "20171170", "url": "https://glygen.org/publication/PubMed/20171170" }, { "database": "PubMed", "id": "19509060", "url": "https://glygen.org/publication/PubMed/19509060" }, { "database": "PubMed", "id": "21063390", "url": "https://glygen.org/publication/PubMed/21063390" }, { "database": "PubMed", "id": "16933150", "url": "https://glygen.org/publication/PubMed/16933150" }, { "database": "PubMed", "id": "20935635", "url": "https://glygen.org/publication/PubMed/20935635" }, { "database": "PubMed", "id": "18480403", "url": "https://glygen.org/publication/PubMed/18480403" }, { "database": "PubMed", "id": "20360007", "url": "https://glygen.org/publication/PubMed/20360007" }, { "database": "PubMed", "id": "27238018", "url": "https://glygen.org/publication/PubMed/27238018" }, { "database": "PubMed", "id": "23601106", "url": "https://glygen.org/publication/PubMed/23601106" }, { "database": "PubMed", "id": "16407259", "url": "https://glygen.org/publication/PubMed/16407259" }, { "database": "PubMed", "id": "26829474", "url": "https://glygen.org/publication/PubMed/26829474" }, { "database": "PubMed", "id": "32351706", "url": "https://glygen.org/publication/PubMed/32351706" }, { "database": "PubMed", "id": "19917720", "url": "https://glygen.org/publication/PubMed/19917720" }, { "database": "PubMed", "id": "30723163", "url": "https://glygen.org/publication/PubMed/30723163" }, { "database": "PubMed", "id": "20937773", "url": "https://glygen.org/publication/PubMed/20937773" }, { "database": "PubMed", "id": "16371510", "url": "https://glygen.org/publication/PubMed/16371510" }, { "database": "PubMed", "id": "30704899", "url": "https://glygen.org/publication/PubMed/30704899" }, { "database": "UniProtKB", "id": "P39951", "url": "https://www.uniprot.org/uniprot/P39951#function" }, { "database": "PubMed", "id": "23602554", "url": "https://glygen.org/publication/PubMed/23602554" }, { "database": "PubMed", "id": "23355470", "url": "https://glygen.org/publication/PubMed/23355470" }, { "database": "PubMed", "id": "34741373", "url": "https://glygen.org/publication/PubMed/34741373" } ] }, { "annotation": "The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2023].", "evidence": [ { "database": "RefSeq", "id": "NP_001307847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307847" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "P06493", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P06493" } ], "glycoeffect": [], "start_pos": 275, "end_pos": 275, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "Q", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "10", "chr_pos": "60793905", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "R275", "disease": [ { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" 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"description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL 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"name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P06493", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06493" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "P06493", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06493" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "P06493", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06493" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "P06493", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06493" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine 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"resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "P06493", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06493" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P06493", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06493" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "P06493", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06493" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "P06493", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06493" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06493" } ], "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Esophageal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:5041", "evidence": [ { "database": "BioXpress", "id": "P06493", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P06493" } ], "disease": [ { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": 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"MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM", "length": 297, "header": "sp|P06493-1|CDK1_HUMAN Isoform 1 of Cyclin-dependent kinase 1 OS=Homo sapiens OX=9606 GN=CDK1 PE=1 SV=3 CANONICAL=P06493-1" }, "locus": { "chromosome": "10", "start_pos": 60793972, "end_pos": 60780166, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000395284.8", "url": "https://www.ensembl.org/id/ENST00000395284.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000378699.3", "url": "https://www.ensembl.org/id/ENSP00000378699.3" } ] } }, { "isoform_ac": "P06493-2", "url": "", "sequence": { "sequence": "MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM", "length": 240, "header": "sp|P06493-2|CDK1_HUMAN Isoform 2 of Cyclin-dependent kinase 1 OS=Homo sapiens OX=9606 GN=CDK1 PE=1 SV=3 CANONICAL=P06493-1" }, "locus": { "chromosome": "10", "start_pos": 60793972, "end_pos": 60780166, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000316629.8", "url": "https://www.ensembl.org/id/ENST00000316629.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000325970.4", "url": "https://www.ensembl.org/id/ENSP00000325970.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "P06493", "database": 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"residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "P06493", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06493" } ], "site_lbl": "Thr141" }, { "start_pos": 14, "end_pos": 14, "kinase_uniprot_canonical_ac": "Q01538-1", "kinase_gene_name": "MYT1", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P06493", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06493" }, { "database": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" }, { "database": "PubMed", "id": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "spindle microtubule", "id": "GO:0005876", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005876", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "mitotic spindle", "id": "GO:0072686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072686", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "cyclin-dependent protein kinase holoenzyme complex", "id": "GO:0000307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000307", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "chromosome, telomeric region", "id": "GO:0000781", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000781", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "cyclin B1-CDK1 complex", "id": "GO:0097125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097125", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "cyclin A2-CDK1 complex", "id": "GO:0097122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097122", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 48, "go_terms": [ { "name": "positive regulation of protein import into nucleus", "id": "GO:0042307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042307", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "microtubule cytoskeleton organization involved in mitosis", "id": "GO:1902850", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902850", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "protein phosphorylation", "id": "GO:0006468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006468", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "positive regulation of G2/M transition of mitotic cell cycle", "id": "GO:0010971", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010971", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "epithelial cell differentiation", "id": "GO:0030855", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030855", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "response to ethanol", "id": "GO:0045471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045471", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "G2/M transition of mitotic cell cycle", "id": "GO:0000086", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000086", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "DNA replication", "id": "GO:0006260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006260", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "response to cadmium ion", "id": "GO:0046686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046686", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "response to toxic substance", "id": "GO:0009636", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009636", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "cellular response to hydrogen peroxide", "id": "GO:0070301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070301", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "ERK1 and ERK2 cascade", "id": "GO:0070371", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070371", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "response to activity", "id": "GO:0014823", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014823", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "regulation of circadian rhythm", "id": "GO:0042752", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042752", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "rhythmic process", "id": "GO:0048511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048511", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "G1/S transition of mitotic cell cycle", "id": "GO:0000082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000082", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "peptidyl-threonine phosphorylation", "id": "GO:0018107", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018107", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "animal organ regeneration", "id": "GO:0031100", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031100", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "response to copper ion", "id": "GO:0046688", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046688", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "response to axon injury", "id": "GO:0048678", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048678", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "microtubule cytoskeleton organization", "id": "GO:0000226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000226", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "peptidyl-serine phosphorylation", "id": "GO:0018105", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018105", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "response to xenobiotic stimulus", "id": "GO:0009410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009410", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "chromosome condensation", "id": "GO:0030261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030261", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "cellular response to organic cyclic compound", "id": "GO:0071407", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071407", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "positive regulation of protein localization to nucleus", "id": "GO:1900182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900182", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "centrosome cycle", "id": "GO:0007098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007098", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "positive regulation of DNA replication", "id": "GO:0045740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045740", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "fibroblast proliferation", "id": "GO:0048144", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048144", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "response to amine", "id": "GO:0014075", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014075", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "ventricular cardiac muscle cell development", "id": "GO:0055015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055015", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "mitotic G2 DNA damage checkpoint signaling", "id": "GO:0007095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007095", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "protein localization to kinetochore", "id": "GO:0034501", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034501", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "positive regulation of cardiac muscle cell proliferation", "id": "GO:0060045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060045", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "pronuclear fusion", "id": "GO:0007344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007344", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "regulation of Schwann cell differentiation", "id": "GO:0014038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014038", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "regulation of embryonic development", "id": "GO:0045995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045995", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "Golgi disassembly", "id": "GO:0090166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090166", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "positive regulation of mitochondrial ATP synthesis coupled electron transport", "id": "GO:1905448", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905448", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "protein-containing complex assembly", "id": "GO:0065003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0065003", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" }, { "name": "positive regulation of mitotic sister chromatid segregation", "id": "GO:0062033", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062033", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [ { "annotation": "Phosphorylation at Thr-161 by CAK/CDK7 activates kinase activity. Phosphorylation at Thr-14 and Tyr-15 by PKMYT1 prevents nuclear translocation. Phosphorylation at Tyr-15 by WEE1 and WEE2 inhibits the protein kinase activity and acts as a negative regulator of entry into mitosis (G2 to M transition). Phosphorylation by PKMYT1 and WEE1 takes place during mitosis to keep CDK1-cyclin-B complexes inactive until the end of G2. By the end of G2, PKMYT1 and WEE1 are inactivated, but CDC25A and CDC25B are activated. Dephosphorylation by active CDC25A and CDC25B at Thr-14 and Tyr-15, leads to CDK1 activation at the G2-M transition. Phosphorylation at Tyr-15 by WEE2 during oogenesis is required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, leading to prevent meiotic reentry. Phosphorylation by WEE2 is also required for metaphase II exit during egg activation to ensure exit from meiosis in oocytes and promote pronuclear formation. Phosphorylated at Tyr-4 by PKR/EIF2AK2 upon genotoxic stress. This phosphorylation triggers CDK1 polyubiquitination and subsequent proteolysis, thus leading to G2 arrest. In response to UV irradiation, phosphorylation at Tyr-15 by PRKCD activates the G2/M DNA damage checkpoint.", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" }, { "database": "PubMed", "id": "20395957", "url": "https://glygen.org/publication/PubMed/20395957" }, { "database": "PubMed", "id": "7569953", "url": "https://glygen.org/publication/PubMed/7569953" }, { "database": "PubMed", "id": "3289755", "url": "https://glygen.org/publication/PubMed/3289755" }, { "database": "PubMed", "id": "19917613", "url": "https://glygen.org/publication/PubMed/19917613" }, { "database": "PubMed", "id": "20360007", "url": "https://glygen.org/publication/PubMed/20360007" } ] }, { "annotation": "Polyubiquitinated upon genotoxic stress.", "evidence": [ { "database": "UniProtKB", "id": "P06493", "url": "https://www.uniprot.org/uniprot/P06493" }, { "database": "PubMed", "id": "20395957", "url": "https://glygen.org/publication/PubMed/20395957" } ] } ], "interactions": [], "reactions": [ { "id": "10216", "name": "", "equation": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P51952-1", "Q3MJK5-1", "Q641Z4-1", "P39951-1", "Q63470-1", "A0A8I5ZYM4-1", "P06493-1", "Q9NYV4-1", "P50750-1", "Q14004-1", "P50613-1", "P49336-1", "Q13627-1", "Q8R3L8-1", "Q14AX6-1", "Q03147-1", "Q69ZA1-1", "Q99J95-1", "P11440-1", "Q61214-1", "P23293-1", "P06242-1", "P39073-1", "Q03957-1", "P34112-1", "P54685-1", "Q95YH0-1", "P23573-1", "P23572-1", "Q9VT57-1", "Q9VP22-1", "Q24216-1" ], "evidence": [ { "id": "10216", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10216" } ] }, { "id": "17989", "name": "", "equation": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "B2DD29-1", "D3ZML2-1", "O08875-1", "O35831-1", "D3ZHP7-1", "D4A280-1", "E9PTG8-1", "O35832-1", "O54748-1", "P57760-1", "Q62868-1", "D3ZBE5-1", "P59895-1", "O55099-1", "O88764-1", "P59241-1", "Q91XS8-1", "Q63644-1", "Q7TQP6-1", "Q9Z2P5-1", "P11345-1", "P11275-1", "F1LYY7-1", "Q9JIH7-1", "P14056-1", "P35426-1", "P51952-1", "P63086-1", "Q5U2X5-1", "Q5XIT0-1", "Q63117-1", "F1M7Y5-1", "P47196-1", "P47197-1", "P97874-1", "Q03114-1", "Q3MJK5-1", "Q09137-1", "Q4V8A3-1", "P54645-1", "Q63686-1", "P08413-1", "P0C1X8-1", "P19139-1", "D4A7V9-1", "Q63184-1", "Q63484-1", "Q9Z1Z1-1", "Q4KM34-1", "Q4KM47-1", "O08874-1", "O70444-1", "O88831-1", "P0C0R5-1", "P26794-1", "P46892-1", "Q66HE7-1", "Q6XUX2-1", "Q62915-1", "Q63185-1", "Q63470-1", "Q62673-1", "Q63433-1", "P53669-1", "P53670-1", "Q63699-1", "Q641Z4-1", "Q91ZN7-1", "A0A0G2K344-1", "P18265-1", "P39951-1", "B2GUY1-1", "B0LT89-1", "A1A5Q6-1", "F1LP90-1", "O08815-1", "O88850-1", "P00539-1", "P0C865-1", "P27791-1", "P63319-1", 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"Q9VP22-1", "Q9W1B0-1", "Q9V3I5-1", "Q9VRJ6-1", "Q8T9L5-1", "Q94533-1", "Q9VUQ9-1", "Q9VGF9-1", "Q9VBU2-1", "Q9VR42-1", "Q9VL34-1", "Q9VTL5-1", "Q95TN8-1", "Q9VCV0-1", "Q8MSQ4-1", "Q9VE06-1", "Q9VJ30-1", "Q9VXN5-1", "M9PGC5-1", "Q9VN23-1", "M9NGC6-1", "O61444-1", "O62602-1", "Q9VUV4-1", "Q9VMY8-1", "Q9VD82-1", "A0A6M3Q7C8-1", "Q9W3N8-1", "Q95SH0-1", "Q9VI84-1", "Q9VEN3-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "B2DD29-1", "D3ZML2-1", "O08875-1", "O35831-1", "P57760-1", "D3ZHP7-1", "D4A280-1", "E9PTG8-1", "O35832-1", "O54748-1", "Q62868-1", "D3ZBE5-1", "P59895-1", "O55099-1", "O88764-1", "P59241-1", "Q91XS8-1", "Q63644-1", "Q7TQP6-1", "Q9Z2P5-1", "P11345-1", "P11275-1", "F1LYY7-1", 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"Q06098-1", "Q08732-1", "Q12152-1", "Q12222-1", "Q12310-1", "Q54FH3-1", "Q54R98-1", "Q54RP7-1", "Q55FJ6-1", "Q55GG4-1", "Q54C38-1", "Q54DY0-1", "Q54E34-1", "Q54EM1-1", "Q54ER4-1", "Q54ET3-1", "Q54F40-1", "Q54FR9-1", "Q54G43-1", "Q54H05-1", "Q54HD2-1", "Q54IF2-1", "Q54IH8-1", "Q54IP4-1", "Q54JQ1-1", "Q54L00-1", "Q54L81-1", "Q54LH8-1", "Q54LU8-1", "Q54MH0-1", "Q54MV2-1", "Q54P26-1", "Q54PK8-1", "Q54PX0-1", "Q54QD5-1", "Q54R95-1", "Q54RB2-1", "Q54RJ4-1", "Q54RR9-1", "Q54RV3-1", "Q54RZ7-1", "Q54SC4-1", "Q54SK3-1", "Q54TA3-1", "Q54TH6-1", "Q54TN4-1", "Q54U31-1", "Q54U65-1", "Q54UA9-1", "Q54UZ1-1", "Q54V35-1", "Q54V83-1", "Q54VC0-1", "Q54VU4-1", "Q54VV7-1", "Q54WC0-1", "Q54WD7-1", "Q54WE5-1", "Q54WW7-1", "Q54XJ4-1", "Q54XX5-1", "Q54XY6-1", "Q54XZ5-1", "Q54Y06-1", "Q54Y55-1", "Q54Y90-1", "Q54YZ5-1", "Q54ZN3-1", "Q552C1-1", "Q552E9-1", "Q552Z2-1", "Q553E9-1", "Q556J6-1", "Q559A2-1", "Q559T8-1", "Q55A09-1", "Q55A55-1", "Q55BA0-1", "Q55CA6-1", "Q55CE0-1", "Q55CW2-1", "Q55CW3-1", "Q55DJ9-1", "Q55DK2-1", "Q55DU7-1", "Q55EI8-1", "Q55F45-1", "Q55FV4-1", "Q55FV5-1", "Q55GC2-1", "Q55GE6-1", "Q55GS4-1", "Q55GU0-1", "Q6XHA7-1", "Q75JN1-1", "Q76P07-1", "Q869L4-1", "Q869T7-1", "Q869X3-1", "Q86A12-1", "Q86HG9-1", "Q86HW6-1", "Q86I06-1", "Q8MYF1-1", "Q8SSV3-1", "Q9NGW9-1", "P0CD62-1", "P34100-1", "P34102-1", "P34103-1", "Q1ZXC8-1", "Q1ZXH2-1", "Q1ZXI5-1", "Q1ZXR2-1", "Q23915-1", "Q54HS0-1", "O61122-1", "O61125-1", "P28178-1", "P34099-1", "P34101-1", "P34112-1", "P34117-1", "P42525-1", "P54644-1", "P54685-1", "Q02720-1", "Q1ZXD6-1", "Q54B33-1", "Q54B48-1", "Q54BC9-1", "Q54BF0-1", "Q54C18-1", "Q54C71-1", "Q54D75-1", "Q54DC8-1", "Q54DF2-1", "Q54DK3-1", "Q54EG9-1", "Q54EY4-1", "Q54GY6-1", "Q54H45-1", "Q54H46-1", "Q54HC6-1", "Q54I36-1", "Q54IE8-1", "Q54JC7-1", "Q54JG7-1", "Q54LR6-1", "Q54M77-1", "Q54MY9-1", "Q54P47-1", "Q54PK9-1", "Q54Q69-1", "Q54QB1-1", "Q54QI2-1", "Q54QQ1-1", "Q54QV3-1", "Q54R82-1", "Q54RB7-1", "Q54S77-1", "Q54T05-1", "Q54TA1-1", "Q54TM7-1", "Q54TW2-1", "Q54UC0-1", "Q54UL8-1", "Q54VD8-1", "Q54VI1-1", "Q54W07-1", "Q54WJ0-1", "Q54WS5-1", "Q54WX4-1", "Q54XL6-1", "Q54XQ2-1", "Q54Y26-1", "Q54YF2-1", "Q550K8-1", "Q550L8-1", "Q551H4-1", "Q552C6-1", "Q556Q3-1", "Q556S2-1", "Q556Y4-1", "Q557G1-1", "Q558U1-1", "Q55BN8-1", "Q55CL6-1", "Q55CY9-1", "Q55CZ1-1", "Q55D99-1", "Q55DD4-1", "Q55DJ8-1", "Q55E58-1", "Q55EC7-1", "Q55FS2-1", "Q55FT4-1", "Q55GJ2-1", "Q55GV3-1", "Q5VJL3-1", "Q6B9X6-1", "Q6XHA5-1", "Q6XHB2-1", "Q75JK0-1", "Q76NV1-1", "Q869N2-1", "Q86AE1-1", "Q86AT8-1", "Q86C65-1", "Q86CS2-1", "Q86HN7-1", "Q86IX1-1", "Q8MVR1-1", "Q8SSS9-1", "Q8SSY6-1", "Q8T2I8-1", "Q95YH0-1", "O61267-1", "P13677-1", "P23573-1", "P51123-1", "Q00168-1", "Q23977-1", "Q24210-3", "Q9VKN7-1", "O62618-1", "P10676-1", "P18431-2", "P23647-1", "P52304-1", "P83098-1", "P83104-1", "Q03042-1", "Q70PP2-1", "Q8T0S6-1", "P12370-1", "Q05652-1", "Q9VXE5-1", "P83103-1", "Q7KRY6-1", "Q95UN8-1", "Q8INB9-1", "A0A0B4KHX7-1", "A1Z9X0-1", "P08181-1", "P11346-1", "M9PI41-1", "Q9VM90-1", "A1ZBL9-1", "O76324-1", "P13678-1", "P16912-1", "P23572-1", "P40417-3", "P48609-1", "P49071-1", "P49762-1", "P54367-1", "P83099-1", "P83100-1", "P83102-1", "P92208-1", "Q03043-1", "Q0KHT7-1", "Q24324-1", "Q5EAK6-1", "Q9NIV1-1", "Q9VPC0-1", "Q9VXG8-1", "Q9W354-1", "A1Z7T0-1", "O61443-1", "O97143-1", "P05130-1", "P16911-1", "P49657-1", "Q9NI63-1", "Q9V3Q6-1", "Q9VA38-1", "Q9VK45-1", "Q9W0V1-4", "P54360-1", "Q9VT57-1", "Q9VI13-1", "A1ZBC4-1", "Q8IMC6-1", "Q8IR79-1", "Q9V3D5-1", "Q0KHQ5-1", "Q0KHV6-1", "Q9NBK5-1", "Q7PLI7-1", "X2JAG8-1", "O61661-1", "A4VCL2-2", "A0A0B4KHT3-1", "A0A4D6K823-1", "Q9VP22-1", "Q9VZI2-1", "Q9W1B0-1", "Q9V3I5-1", "A1ZBH7-1", "Q9W002-1", "Q9VRJ6-1", "Q8T9L5-1", "Q94533-1", "Q9VUQ9-1", "Q9VXE3-1", "Q9VGF9-1", "Q9VBU2-1", "Q9VR42-1", "Q9VW24-1", "A0A0B4KHC3-1", "Q9VL34-1", "Q9VTL5-1", "Q95TN8-1", "Q9VCV0-1", "Q8MSQ4-1", "Q9VE06-1", "Q9VJ30-1", "Q9VXN5-1", "M9PGC5-1", "Q9VN23-1", "M9NGC6-1", "O61444-1", "O62602-1", "Q9VUV4-1", "Q9VMY8-1", "Q9VD82-1", "A0A6M3Q7C8-1", "Q9W3N8-1", "Q95SH0-1", "Q9VJC2-1", "Q9VI84-1", "Q9VEN3-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] }, { "id": "R-HSA-112342", "name": "Inactivation of MAP2K1 by CDK1", "equation": "", "summary": "At the beginning of this reaction, 2 molecules of 'ATP', and 1 molecule of 'MEK1' are present. At the end of this reaction, 1 molecule of 'phospho_MEK1', and 2 molecules of 'ADP' are present.
This reaction takes place in the 'cytosol' and is mediated by the 'protein serine/threonine kinase activity' of 'phospho-Cdc2 (Thr 161)'(Shah et al.2003 ).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06493-1", "Q02750-1" ], "evidence": [ { "id": "R-HSA-112342", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-112342" } ] }, { "id": "R-HSA-113638", "name": "Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation", "equation": "", "summary": "This event is inferred from the fission yeast. Cyclin B activity is thought to inhibit pre-RC formation by first associating with ORC during DNA replication.", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06493-1", "Q9UJA3-1" ], "evidence": [ { "id": "R-HSA-113638", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-113638" } ] }, { "id": "R-HSA-170044", "name": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus", "equation": "", "summary": "During interphase, cyclin B1:Cdc2 shuttles continuously in and out of the nucleus. Cyclin B1:Cdc2 is transported into the nucleus by an unusual mechanism that requires importin b but not importin a or Ran. Dissociation of the cyclin-B1:Cdc2:importin complex in the nucleus requires ATP and involves\n other yet unidentified nuclear factors (Takizawa et al.,1991).", "cellular_location": "nuclear envelope", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06493-1" ], "evidence": [ { "id": "R-HSA-170044", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-170044" } ] }, { "id": "R-HSA-170055", "name": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes", "equation": "", "summary": "Myt1, which localizes preferentially to the endoplasmic reticulum and Golgi complex, phosphorylates Cdc2 on threonine 14 ( Liu et al., 1997).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06493-1", "Q99640-1" ], "evidence": [ { "id": "R-HSA-170055", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-170055" } ] }, { "id": "R-HSA-170057", "name": "Formation of Cyclin B:Cdc2 complexes", "equation": "", "summary": "Cyclin dependent kinases are themselves catalytically inactive due to the fact that their active site is blocked by a portion of the Cdk molecule itself. Binding to their corresponding cyclin partner results in conformational change that partially exposes the active site. The two B-type cyclins localize to different regions within the cell and and are thought to have specific roles as CDK1-activating subunits (see Bellanger et al., 2007). Cyclin B1 is primarily cytoplasmic during interphase and translocates into the nucleus at the onset of mitosis (Jackman et al., 1995; Hagting et al., 1999). Cyclin B2 colocalizes with the Golgi apparatus and contributes to its fragmentation during mitosis (Jackman et al., 1995; Draviam et al., 2001).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06493-1" ], "evidence": [ { "id": "R-HSA-170057", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-170057" } ] }, { "id": "R-HSA-170070", "name": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes", "equation": "", "summary": "WEE1, a nuclear kinase, phosphorylates cyclin B1:Cdc2 (CCNB1:CDK1) on tyrosine 15 (Y15), inactivating the complex (Parker and Piwnica-Worms 1992, McGowan and Russell 1993). The complex of cyclin B2 and Cdc2 (CCNB2:CDK1) is also phosphorylated on Y15 (Galaktionov and Beach 1991).", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-HSA-170073" ], "output_participant_list": [ "R-HSA-170065" ], "enzyme_list": [ "P30291-1", "P06493-1" ], "evidence": [ { "id": "R-HSA-170070", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-170070" } ] }, { "id": "R-HSA-170072", "name": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm", "equation": "", "summary": "During interphase, cyclin B1 shuttles continuously in and out of the nucleus. The cyclin B cytoplasmic retention sequence (CRS), which is responsible for its interphase cytoplasmic localization, functions as a nuclear export sequence (Yang et al., 1998).", "cellular_location": "nuclear envelope", "input_participant_list": [], "output_participant_list": [ "R-HSA-170068" ], "enzyme_list": [ "P06493-1" ], "evidence": [ { "id": "R-HSA-170072", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-170072" } ] }, { "id": "R-HSA-170076", "name": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes", "equation": "", "summary": "Full activity of most CDKs is dependent on CAK mediated phosphorylation at a conserved residue (Thr161 in Cdc2). This modification is thought to improve substrate binding. Cyclin B:Cdc2 complexes have considerably low activity in the absence of CAK mediated phosphorylation (Desai et al 1995).", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-HSA-170056" ], "output_participant_list": [], "enzyme_list": [ "P06493-1", "P50613-1" ], "evidence": [ { "id": "R-HSA-170076", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-170076" } ] }, { "id": "R-HSA-170084", "name": "Formation of Cyclin A:Cdc2 complexes", "equation": "", "summary": "Cyclin A is synthesized and associates with Cdc2 in G1. Cyclin dependent kinases are themselves catalytically inactive due to the fact that their active sites are blocked by a portion of the CDK molecule itself. Binding to their corresponding cyclin partner results in a conformational change that partially exposes the active site.", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06493-1" ], "evidence": [ { "id": "R-HSA-170084", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-170084" } ] }, { "id": "R-HSA-170087", "name": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes", "equation": "", "summary": "Full activity of most CDKs is dependent on CAK mediated phosphorylation at a conserved residue (Thr 161 in Cdc2). This modification is thought to improve substrate binding. High affinity binding of Cyclin A within the Cyclin A:Cdc2 complex requires this phosphorylation (Desai et al 1995).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06493-1", "P50613-1" ], "evidence": [ { "id": "R-HSA-170087", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-170087" } ] }, { "id": "R-HSA-170088", "name": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus", "equation": "", "summary": "Cyclin A:Cdc2 complexes translocate to the nucleus in G1 and may associate with condensing chromosomes in prophase (Pines and Hunter 1991).", "cellular_location": "nuclear envelope", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06493-1" ], "evidence": [ { "id": "R-HSA-170088", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-170088" } ] }, { "id": "R-HSA-170116", "name": "Myt-1 mediated phosphorylation of Cyclin A:Cdc2", "equation": "", "summary": "Myt1, which localizes preferentially to the endoplasmic reticulum and Golgi complex, phosphorylates Cdc2 on threonine 14 ( Liu et al., 1997).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06493-1", "Q99640-1" ], "evidence": [ { "id": "R-HSA-170116", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-170116" } ] }, { "id": "R-HSA-170126", "name": "Phosphorylation of Cyclin B1 in the CRS domain", "equation": "", "summary": "At the onset of mitosis, cyclin B is phosphorylated in the CRS sequence which creates a nuclear import signal in the amino terminus. The kinase(s) responsible for this phosphorylation are not yet known (Hagting et al., 1999).", "cellular_location": "cytosol", "input_participant_list": [ "R-HSA-157456" ], "output_participant_list": [ "R-HSA-170121" ], "enzyme_list": [ "P06493-1", "P53350-1" ], "evidence": [ { "id": "R-HSA-170126", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-170126" } ] }, { "id": "R-HSA-170131", "name": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes", "equation": "", "summary": "The rapid translocation of cyclin B1:Cdc2 from the cytoplasm to the nucleus at the onset of mitosis is a result of an increase in the rate of import and, likely, a\n decreased rate of export. The increased rate of nuclear import is dependent upon phosphorylation of the CRS which creates a nuclear import signal in the amino terminus of cyclin B1 (Hagting et al, 1999).", "cellular_location": "nuclear envelope", "input_participant_list": [ "R-HSA-170047" ], "output_participant_list": [ "R-HSA-170127" ], "enzyme_list": [ "P06493-1" ], "evidence": [ { "id": "R-HSA-170131", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-170131" } ] }, { "id": "R-HSA-170153", "name": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases", "equation": "", "summary": "Following its translocation to the nucleus, Cdc25 dephosphorylates and activates nuclear cyclin B1:Cdc2 complexes (Strausfeld et al., 1991).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [ "R-HSA-170160" ], "enzyme_list": [ "P30304-1", "P30305-1", "P30307-1", "P06493-1" ], "evidence": [ { "id": "R-HSA-170153", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-170153" } ] }, { "id": "R-HSA-170156", "name": "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes", "equation": "", "summary": "The human Wee1 kinase phosphorylates Cdc2 on tyrosine 15 inactivating the cyclin:CDK complex (Watanabe et al., 1995).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P30291-1", "P06493-1" ], "evidence": [ { "id": "R-HSA-170156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-170156" } ] }, { "id": "R-HSA-170158", "name": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes", "equation": "", "summary": "Activation of the cyclin A:Cdc2 complexes at mitosis requires the removal of the inhibitory phosphate groups on Cdc2 (CDK1). This dephosphorylation is achieved by the activity of the CDC25A phosphatase (Timofeev et al. 2009). CDC25A, CDC25B, and CDC25C are kept inactive during interphase and are activated at the G2/M transition (see Wolfe and Gould 2004).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P30304-1", "P06493-1" ], "evidence": [ { "id": "R-HSA-170158", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-170158" } ] }, { "id": "R-HSA-170161", "name": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B", "equation": "", "summary": "Activation of the mitotic cyclinB:Cdc2 (CCNB:CDK1) complexes at mitosis requires the removal of the inhibitory phosphate groups on Cdc2 (CDK1). This dephosphorylation is achieved by the activity of the CDC25 family of phosphatases, which act on both CCNB1 and CCNB2-bound CDK1 (Galaktionov and Beach 1991, Goda et al. 2003, Timofeev et al. 2010). The CDC25 members, CDC25A, CDC25B, and CDC25C are kept inactive during interphase and are activated at the G2/M transition. CCNB:CDK1 complexes appear to participate in the full activation of CDC25 in a process that involves an amplification loop (see Wolfe and Gould, 2004). The initial activation of the CCNB:CDK1 (cyclin B1:Cdc2 and cyclin-B2:Cdc2) complexes occurs in the cytoplasm in prophase (Jackman et al., 2003). CDC25B, which is present at highest concentrations in the cytoplasm at this time, is thought to trigger the activation of CCNB1:CDK1 (Lindqvist et al. 2004; Honda et al., 1993). Active CCNB1:CDK1 then phosphorylates CDC25C (contributing to its PLK1-mediated activation) and stabilizes CDC25A (Strausfeld et al., 1994; Hoffman et al.,1993; Mailand et al, 2002). This creates positive feedback loops that allows CDC25A and CDC25C to dephosphorylate and further activate CDK1. As active CDC25C is nuclear, it presumably predominantly contributes to activation of nuclear CDK1 (Strausfeld et al. 1994, Toyoshima-Morimoto et al. 2002, Bonnet, Coopman et al. 2008, Bonnet Mayonove et al. 2008).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P30305-1", "P06493-1" ], "evidence": [ { "id": "R-HSA-170161", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-170161" } ] }, { "id": "R-HSA-174104", "name": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex", "equation": "", "summary": "Rape et al. have recently demonstrated that the order in which APC/C targeted proteins are degraded is determined by the processivity of multiubiquitination of these substrates. Processive substrates acquire a polyubiquitin chain upon binding to the APC/C once and are degraded. Distributive substrates bind, dissociate and reassociate with the APC/C multiple times before acquiring an ubiquitin chain of sufficient length to insure degradation. In addition, distributive substrates that dissociate from the APC/C with short ubiquitin chains are targeted for deubiquitination (Rape et al., 2006). Paradoxically, although the multiubiquitination of cyclin A is distributive and later substrates of APC-Cdc20 such as Securin are processive (Rape et al., 2006), Cyclin A is degraded prior to Securin and Cyclin B. The mechanisms insuring this order have not yet be determined.", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q16763-1", "P06493-1", "P51668-1", "P51965-1", "O60566-1", "O00762-1" ], "evidence": [ { "id": "R-HSA-174104", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174104" } ] }, { "id": "R-HSA-174120", "name": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex", "equation": "", "summary": "Cyclin B is believed to be recognized by the APC/C:Cdc20 complex through its D-box sequence.", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q16763-1", "P06493-1", "P51668-1", "P51965-1", "O00762-1" ], "evidence": [ { "id": "R-HSA-174120", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174120" } ] }, { "id": "R-HSA-174122", "name": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2", "equation": "", "summary": "Emi1 is also believed to be phosphorylated by Cyclin B:Cdc2 on a CDK consensus site at Ser 182. While Plk1 mediated phosphorylation of Emi1 at the DSGxxS (\u00dfTrCP recognition) motif is essential for Emi1 destruction in mitosis, Cdk phosphorylation has been shown to play an important regulatory role.", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06493-1" ], "evidence": [ { "id": "R-HSA-174122", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174122" } ] }, { "id": "R-HSA-174132", "name": "Free APC/C phosphorylated by Cyclin B:Cdc2", "equation": "", "summary": "Phosphorylation of the APC/C is believed to be required for its activation. While the identity of the essential phosphorylation sites and the kinase(s) responsible are not known with certainty, in vitro studies have shown that the Apc1 and the tetratricopeptide repeat (TPR) subunits Cdc27, Cdc16, Cdc23 and Apc7 are phosphorylated and that the Cdk1 and Plk1 kinases may play a role.", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q16763-1", "P06493-1", "P51668-1", "P51965-1", "O00762-1" ], "evidence": [ { "id": "R-HSA-174132", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174132" } ] }, { "id": "R-HSA-174157", "name": "Degradation of multiubiquitinated Cyclin B", "equation": "", "summary": "Mulitubiquitinated Cyclin B is targeted for degradation by the 26S proteasome.", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q16763-1", "P06493-1", "P51668-1", "P51965-1", "O00762-1" ], "evidence": [ { "id": "R-HSA-174157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174157" } ] }, { "id": "R-HSA-174171", "name": "Association of Cyclin A with the APC/C", "equation": "", "summary": "Cyclin A is believed to be recognized by the APC/C:Cdc20 complex through its D-box sequence, which is 10-20 residues longer than the D-box of cyclin B (Geley et al., 2001).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q16763-1", "P06493-1", "P51668-1", "P51965-1", "O60566-1", "O00762-1" ], "evidence": [ { "id": "R-HSA-174171", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174171" } ] }, { "id": "R-HSA-174227", "name": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex", "equation": "", "summary": "At the beginning of this reaction, 1 molecule of 'Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex', and 3 molecules of 'ubiquitin' are present. At the end of this reaction, 1 molecule of 'multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex' is present.

This reaction takes place in the 'cytosol' and is mediated by the 'ubiquitin-protein ligase activity' of 'Cdc20:Phospho-APC/C'.
", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q16763-1", "P06493-1", "P51668-1", "P51965-1", "O00762-1" ], "evidence": [ { "id": "R-HSA-174227", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174227" } ] }, { "id": "R-HSA-174251", "name": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2", "equation": "", "summary": "At the onset of mitosis, Cdh1 is phosphorylated by Cyclin B-Cdc2 resulting in a conformational change that prevents Cdh1 from activating the APC/C.", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-HSA-174099" ], "output_participant_list": [ "R-HSA-174257" ], "enzyme_list": [ "P06493-1" ], "evidence": [ { "id": "R-HSA-174251", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174251" } ] }, { "id": "R-HSA-174255", "name": "Degradation multiubiquitinated Cyclin A", "equation": "", "summary": "Following multiubiquitination, Cyclin A is targeted for destruction by the 26S proteasome.", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A5LHX3-1", "O00487-1", "P28074-1", "Q99436-1", "Q16763-1", "P06493-1", "P28072-1", "P51668-1", "P51965-1", "O60566-1", "P40306-1", "P28065-1", "P28062-1", "O00762-1" ], "evidence": [ { "id": "R-HSA-174255", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174255" } ] }, { "id": "R-HSA-2172183", "name": "Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB", "equation": "", "summary": "GORASP1 (GRASP65) and GOLGA2 (GM130) form a complex on cis-Golgi membranes. RAB1A or RAB1B, small RAS GTP-ases, can also associate with this complex through interaction with GOLGA2 (Moyer et al. 2001, Weide et al. 2001). GOLGA2 provides a docking site for the USO1 (p115) homodimer (Nakamura et al. 1995, Seeman et al. 2000). RAB1 also participates in this interaction and facilitates it when in the GTP-bound state (Moyer et al. 2001). Binding of USO1 to GORASP1:GOLGA2:RAB1:GTP complex enables fusion of vesicles originating in the endoplasmic reticulum (ER) with cisternae of cis-Golgi.
In mitotic prophase, CDK1 (CDC2) in complex with either CCNB1 (cyclin B1) or CCNB2 (cyclin B2), as both CCNB1 and CCNB2 can localize to Golgi (Jackman et al. 1995, Draviam et al. 2001), phosphorylates GORASP1, GOLGA2 and RAB1 (Bailly et al. 1991, Lowe et al. 1998, Preisinger et al. 2005). Phosphorylation of GOLGA2 and RAB1 impairs their association with USO1, which inhibits thethering and subsequent fusion of ER-originating vesicles with cis-Golgi cisternae, resulting in cessation of ER to Golgi protein trafficking at the start of mitosis and increase in the number of Golgi trafficking vesicles at the expense of Golgi cisternae (Lowe et al. 1998, Seeman et al. 2000, Moyer et al. 2001, Diao et al. 2008).", "cellular_location": "Golgi membrane, cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06493-1", "P62820-1", "Q9H0U4-1" ], "evidence": [ { "id": "R-HSA-2172183", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2172183" } ] }, { "id": "R-HSA-2245218", "name": "CDK1 phosphorylates PHF8", "equation": "", "summary": "Increased activity of CDK1:CCNB1 during the cell cycle promotes PHF8 dissociation from chromatin, while the inhibition of CDK activity promotes binding of PHF8 to chromatin during mitosis. CDK1:CCNB1 complex phosphorylates PHF8 in vitro on serine residues S33 and S84. Mutation of PHF8 phosphorylation sites impairs the dissociation of PHF8 from chromatin and the accumulation of H4K20me1 in prophase (Liu et al. 2010). Positions of CDK1-phosphorylated serine residues in PHF8, S33 and S84, are based on the sequence of PHF8 splicing isoform 2, which was used in the experiments of Liu et al. In PHF8 splicing isoforms 1 and 3, serine residues S69 and S120 are annotated as targets of CDK1-mediated phosphorylation.", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06493-1" ], "evidence": [ { "id": "R-HSA-2245218", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2245218" } ] }, { "id": "R-HSA-2294600", "name": "CDK1 phosphorylates condensin II subunit NCAPD3", "equation": "", "summary": "Phosphorylation of the threonine residue T1415 of condensin II subunit NCAPD3 is required for chromosome condensation in prophase. In vivo, phosphorylation of NCAPD3 threonine residue T1415 is blocked when cells are treated with CDK1 inhibitors. In addition, it was shown that CDK1 in complex with cyclin B1 (CDK1:CCNB1) phosphorylates NCAPD3 at T1415 in vitro (Abe et al. 2011).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06493-1" ], "evidence": [ { "id": "R-HSA-2294600", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2294600" } ] }, { "id": "R-HSA-2430533", "name": "CDK1 phosphorylates MASTL", "equation": "", "summary": "At the beginning of mitosis, MASTL (GWL, Greatwall kinase) is activated by phosphorylation at several key sites. Many of these sites, including functionally important threonine residues T194, T207 and T741 (corresponding to Xenopus residues T193, T206 and T748), are proline directed, matching CDK1 consensus sequence, and thus probably phosphorylated by CDK1, as shown by in vitro studies (Yu et al. 2006. Blake-Hodek et al. 2012). Phosphorylation of the serine residue S875 (S883 in Xenopus) is implicated as critical for the mitotic function of MASTL (Vigneron et al. 2011) and likely occurs through autophosphorylation (Blake-Hodek et al. 2012). Other kinases, such as PLK1 (Vigneron et al. 2011) and other MASTL phosphorylation sites may also be involved in mitotic activation of MASTL (Yu et al. 2006, Vigneron et al. 2011, Blake-Hodek et al. 2012). Phosphorylation of the serine residue S102 (S101 in Xenopus) is functionally important but the responsible kinase has not been identified (Blake-Hodek et al. 2012).", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-HSA-2160957" ], "output_participant_list": [ "R-HSA-2430549" ], "enzyme_list": [ "Q96GX5-1", "P06493-1" ], "evidence": [ { "id": "R-HSA-2430533", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2430533" } ] }, { "id": "R-HSA-2468287", "name": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres", "equation": "", "summary": "Phosphorylation of CDCA5 (Sororin) coincides with dissociation of CDCA5 from chromosomal arms in prometaphase, but phosphorylated CDCA5 persists on centromeres throughout prophase and metaphase. Several serine and threonine residues in CDCA5 are phosphorylated by CDK1 in prometaphase, but only the three sites that perfectly match the CDK1 consensus phosphorylation sequence are shown here - serines S21 and S75 and threonine T159 (Drier et al. 2011, Zhang et al. 2011).", "cellular_location": "chromosome, centromeric region, cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P0DPH7-1", "P67775-1", "Q96GD4-1", "O43683-1", "P36873-1", "P68363-1", "P06493-1", "Q2NKX8-1", "P53350-1", "P62714-1", "Q7L7X3-1", "P49792-1", "O60566-1", "Q6PEY2-1", "P68366-1", "Q71U36-1", "A6NHL2-1", "Q9NY65-1", "Q9BQE3-1", "Q9H853-1", "P0DPH8-1" ], "evidence": [ { "id": "R-HSA-2468287", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2468287" } ] }, { "id": "R-HSA-2468293", "name": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms", "equation": "", "summary": "Phosphorylation of CDCA5 (Sororin) coincides with dissociation of CDCA5 from chromosomal arms in prometaphase. Several serine and threonine residues in CDCA5 are phosphorylated by CDK1 in prometaphase, but only the three sites that perfectly match the CDK1 consensus phosphorylation sequence are shown here - serines S21 and S75 and threonine T159 (Drier et al. 2011, Zhang et al. 2011).", "cellular_location": "chromosome, cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06493-1" ], "evidence": [ { "id": "R-HSA-2468293", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2468293" } ] }, { "id": "R-HSA-2514854", "name": "CDK1 phosphorylates condensin I", "equation": "", "summary": "CDK1 (CDC2) in complex with CCNB (cyclin B) phosphorylates condensin I subunits NCAPD2, NCAPG and NCAPH in mitosis (Kimura et al. 2001, Takemoto et al. 2006), but other mitotic kinases may also be involved. CDK1 phosphorylation sites in NCAPH have not been established. NCAPD2 threonine residues T1339, T1384 and T1389 are inferred to be phosphorylated by CDK1 based on homologues sites in Xenopus laevis Ncapd2 (Kimura et al. 1998). NCAPG threonine residues T308 and T332 are phosphorylated by CDK1 in vitro and functionally important. The functional importance of threonine T931, also phosphorylated by CDK1 in vitro, has not been demonstrated (Murphy et al. 2008). Phosphorylation by CDK1 is required for mitotic activation of condensin I and promotes chromosomal binding, introduction of positive supercoils into DNA, and chromatin condensation (Kimura et al. 1998, Kimura et al. 2001, Takemoto et al. 2006).", "cellular_location": "cytosol", "input_participant_list": [ "R-HSA-1638143" ], "output_participant_list": [ "R-HSA-2520845" ], "enzyme_list": [ "P06493-1" ], "evidence": [ { "id": "R-HSA-2514854", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2514854" } ] }, { "id": "R-HSA-2574840", "name": "AJUBA facilitates AURKA autophosphorylation", "equation": "", "summary": "AURKA (Aurora A kinase) activation through autophosphorylation of threonine T288 is facilitated by AJUBA binding. AJUBA is also phosphorylated by AURKA on an unidentified serine or threonine residue (Hirota et al. 2003).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-HSA-2574841" ], "enzyme_list": [ "P48730-1", "O00444-1", "P17612-1", "P49674-1", "P07900-1", "P51955-1", "O14965-1", "P06493-1", "P53350-1", "P68366-1", "Q71U36-1" ], "evidence": [ { "id": "R-HSA-2574840", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2574840" } ] }, { "id": "R-HSA-2574845", "name": "AJUBA binds centrosome-associated AURKA", "equation": "", "summary": "AJUBA, a LIM domain-containing protein, binds centrosome-associated AURKA (Aurora A kinase) through interaction of LIM-2 and LIM-3 domains of AJUBA with the N-terminus of AURKA (Hirota et al. 2003).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P48730-1", "O00444-1", "P17612-1", "P49674-1", "P07900-1", "P51955-1", "O14965-1", "P06493-1", "P53350-1", "P68366-1", "Q71U36-1" ], "evidence": [ { "id": "R-HSA-2574845", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2574845" } ] }, { "id": "R-HSA-2984220", "name": "CDK1:CCNB phosphorylates NEK9", "equation": "", "summary": "NEK9 functions as a homodimer and becomes catalytically active in mitosis through phosphorylation (Roig et al. 2002). While threonine T333 of NEK9 is phosphorylated in both interphase and mitotic cells (Roig et al. 2005, Bertran et al. 2011), serine residues S29, S750 and S869 of NEK9 are phosphorylated only in mitotic cells. S29, S750 and S869 sites are proline directed and match the CDK1 consensus sequence (Bertran et al. 2011). CDK1:CCNB complex was shown to phosphorylate NEK9 in vitro (Roig et al. 2002).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8TD19-1", "P06493-1" ], "evidence": [ { "id": "R-HSA-2984220", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2984220" } ] }, { "id": "R-HSA-2990882", "name": "CDK1 phosphorylates NUP98", "equation": "", "summary": "CDK1 activity promotes the nuclear pore complex (NPC) disassembly in mitosis (Muhlhausser and Kutay 2007). While NUP98 is probably not the only nucleoporin phosphorylated by CDK1 at mitotic entry, NUP98 is the best characterized CDK1 target among nuclear pore complex components. NUP98 threonine residues T529, T536, and T653, as well as serine residues S595 and S606 were found to be phosphorylated when NUP98 was isolated from mitotic HeLa cells (human cervical carcinoma cell line); these five sites match the CDK1 target site consensus and are phosphorylated by CDK1:CCNB in vitro (Laurell et al. 2011). The NUP98 splicing isoform NUP98-4 was used in the study by Laurell et al. 2011 and the indicated positions of phosphorylated amino acid residues refer to this isoform. An additional splicing isoform NUP98-3, the product of an alternative splicing site in exon10 of the NUP98 gene, which is 17 amino acids longer than NUP98-4, could also be a part of the NPC. CDK1-phosphorylated residues in NUP98-3 would be threonines T546, T553 and T670, and serines S612 and S623.", "cellular_location": "cytosol, nuclear envelope", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06493-1", "P49792-1" ], "evidence": [ { "id": "R-HSA-2990882", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2990882" } ] }, { "id": "R-HSA-3000310", "name": "AURKA phosphorylates PLK1", "equation": "", "summary": "AURKA (Aurora A kinase) phosphorylates PLK1 on threonine residue T210 that lies in the conserved aurora kinase consensus site (Seki et al. 2008). PLK1 needs to be phosphorylated on T210 to become catalytically active (Jang et al. 2002). BORA, but not other AURKA co-activators, facilitate PLK1 phosphorylation by AURKA (Macurek et al. 2008, Seki et al. 2008).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P48730-1", "O00444-1", "P17612-1", "P49674-1", "P07900-1", "P51955-1", "O14965-1", "P06493-1", "P53350-1", "P68366-1", "Q71U36-1" ], "evidence": [ { "id": "R-HSA-3000310", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000310" } ] }, { "id": "R-HSA-3000319", "name": "BORA binds PLK1 and AURKA", "equation": "", "summary": "BORA is able to interact with both AURKA (Aurora A kinase) and PLK1. Binding of BORA to PLK1 increases the accessibility of PLK1 threonine residue T210 and also brings PLK1 in proximity to AURKA, enabling AURKA to phosphorylate T210 of PLK1 and thereby activate PLK1 (Seki et al. 2008). While BORA is required for mitotic activation of AURKA in Drosophila (Hutterer et al. 2006), it does not significantly activate AURKA in human cells (Seki et al. 2008). AURKA is able to phosphorylate BORA in vitro, but the functional significance of this modification has not been determined (Hutterer et al. 2006).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P48730-1", "O00444-1", "P17612-1", "P49674-1", "P07900-1", "P51955-1", "O14965-1", "P06493-1", "P53350-1", "P68366-1", "Q71U36-1" ], "evidence": [ { "id": "R-HSA-3000319", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000319" } ] }, { "id": "R-HSA-380272", "name": "Plk1-mediated phosphorylation of Nlp", "equation": "", "summary": "Phosphorylation of NlP by Plk1 regulates the interaction of Nlp with both centrosomes and ?-TuRCs (Casenghi et al., 2003).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P48730-1", "O00444-1", "P17612-1", "P49674-1", "P07900-1", "P51955-1", "P06493-1", "P53350-1", "P68366-1", "Q71U36-1" ], "evidence": [ { "id": "R-HSA-380272", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-380272" } ] }, { "id": "R-HSA-380278", "name": "CCNB1:p-T160-CDK1 phosphorylates NUMA1", "equation": "", "summary": "After the initiation of DNA condensation in prophase of mitosis, NuMA (NUMA1) is phosphorylated on threonine residue 2055 by the complex of Cdc2 (CDK1) kinase and Cyclin B1 (CCNB1). After the nuclear envelope breakdown, phosphorylated NuMA rapidly moves to the centrosomal region (Compton and Luo 1995, Hsu and Yeh 1996, Kotak et al. 2013). Another phosphorylation event occurs when NuMA associates with the mitotic spindle (Gaglio et al. 1995; Hsu and Yeh 1996). While CCNB1:p-T160-CDK1-dependent phosphorylation appears to plays an essential role in the targeting of NuMA to the spindle apparatus (Compton and Luo 1995, Hsu and Yeh 1996, Kotak et al. 2013), there may be additional protein kinases that promote the release of NuMA from the nuclear compartment at nuclear envelope breakdown (Saredi et al. 1997).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06493-1" ], "evidence": [ { "id": "R-HSA-380278", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-380278" } ] }, { "id": "R-HSA-380283", "name": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome", "equation": "", "summary": "Microtubule nucleation at the centrosome is mediated by the gamma tubulin ring complex (gamma TuRC) (reviewed in Raynaud-Messina and Merdes, 2006; Wiese and Zheng, 2006). In humans, this large complex contains the tubulin superfamily member gamma-tubulin, five gamma complex proteins (GCP2-GPC6) and NEDD1/GCP-WD. A current model of the arrangement of subunits within the gamma-TuRC proposes that 6-7 TuSC subcomplexes are held together by the other Grip proteins (at an unknown stoichiometry), which together form the cap subunits. ; In many animal cells, the recruitment of gamma-tubulin complexes to the centrosome rapidly increases (3\u20135 fold ) before mitosis to support the formation of new spindle microtubules (Khodjakov and Rieder 1999). NEDD1/GCP-WD plays an essential role in recruitment of these complexes to the centrosomes (Haren et al., 2006; Luders et al., 2006) and to the mitotic spindle (Luders et al., 2006). GCP-WD/NEDD1 associates directly with the gamma-TuRC. The carboxy-terminal half binds to the gamma-TuRC whereas the amino-terminal half, corresponding to the WD-repeat domain, is responsible for its attachment to the centrosome (Haren et al., 2006). Additional centrosomal proteins have also been implicated in the docking of gamma-TuRC to the centrosomes. CG-NAP/AKAP450 and kendrin are necessary for the initiation of microtubule nucleation and interact with GCP2/GCP3 and GCP2, respectively (Takahashi et al., 2002). Pericentrin plays an important role in microtubule organization in mitotic cells and anchors gamma- TuRC through domains that bind GCP2 and GCP3 (Zimmerman et al. 2004). Ninein localizes to the centriole via its C-terminus and interacts with gamma-tubulin-containing complexes via its N-terminus.

Nucleoside diphosphate kinase (NME7) is a poorly characterised member of the NME family and has been observed to exhibit no NADPK activity (Yoon et al. 2005, Liu et al. 2014). NME7 has recently been found to be a component of the \u03b3-tubulin ring complex (\u03b3TuRC) where it regulates the microtubule-nucleating activity (the event that initiates de novo formation of microtubules) of the \u03b3TuRC. NME7 contains two putative kinase domains, A and B; domain A is involved in autophosphorylation whereas domain B is inactive. NME7 interacts with the \u03b3TuRC through both domains, with Arg-322 in domain B being critical for binding. In association with the \u03b3TuRC, NME7 localizes to centrosomes throughout the cell cycle and to mitotic spindles during mitosis (Liu et al. 2014).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P48730-1", "Q9Y5B8-1", "O00444-1", "P17612-1", "P49674-1", "P07900-1", "P51955-1", "P06493-1", "P53350-1", "P68366-1", "Q71U36-1" ], "evidence": [ { "id": "R-HSA-380283", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-380283" } ] }, { "id": "R-HSA-380294", "name": "Loss of C-Nap-1 from centrosomes", "equation": "", "summary": "The centrosomal protein C-Nap1 is thought to play an important role in centrosome cohesion during interphase (Fry et al.,1998). At the onset of mitosis, when centrosomes separate to form the bipolar spindle, C-Nap1 dissociates (Mayor et al., 2000). Dissociation of C-Nap1 from mitotic centrosomes appears to be regulated by phosphorylation (Mayor et al. 2002).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P48730-1", "O00444-1", "P17612-1", "P49674-1", "P07900-1", "P51955-1", "P06493-1", "P53350-1", "P68366-1", "Q71U36-1" ], "evidence": [ { "id": "R-HSA-380294", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-380294" } ] }, { "id": "R-HSA-380303", "name": "Dissociation of Phospho-Nlp from the centrosome", "equation": "", "summary": "Mitotic activation of Plk1 is required for efficient displacement of Nlp from the centrosome (Casenghi et al., 2003).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P48730-1", "O00444-1", "P17612-1", "P49674-1", "P07900-1", "P51955-1", "P06493-1", "P53350-1", "P68366-1", "Q71U36-1" ], "evidence": [ { "id": "R-HSA-380303", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-380303" } ] }, { "id": "R-HSA-380311", "name": "Recruitment of Plk1 to centrosomes", "equation": "", "summary": "Plk1 is associated with the centrosomes early in mitosis (Golsteyn et al. 1995). Plk1 activity is necessary for the maturation of centrosomes at the G2/M transition and the establishment of a bipolar spindle (Lane and Nigg 1996). Specific inhibitors against Plk1 or silencing of Plk1 produce a monopolar mitotic apparatus (Sumara et al, 2004, van Vugt et al, 2004, McInnes et al, 2006, Peters et al, 2006, L\u00e9n\u00e1rt et al, 2007).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P48730-1", "O00444-1", "P17612-1", "P49674-1", "P07900-1", "P51955-1", "P06493-1", "P53350-1", "P21127-1", "Q9UQ88-1", "P68366-1", "Q71U36-1" ], "evidence": [ { "id": "R-HSA-380311", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-380311" } ] }, { "id": "R-HSA-380316", "name": "Association of NuMA with microtubules", "equation": "", "summary": "NuMA can interact with microtubules by direct binding to tubulin. Binding occurs through amino acids 1868-1967 of human NuMA (tail IIA) and appears to play a role in the organization of the spindle poles by stably crosslinking microtubule fibers (Haren and Merdes 2002). While the exact mechanism of microtubule bundling is not known, NuMA has been shown to form large fibrous networks (Saredi et al. 1996, Gueth-Hallonet et al.1998, Harborth et al.1999) apparently as a result of dimerization of the NuMA rod domains followed by association of multiple NuMA dimers through their tail domains.", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P48730-1", "P0DPH7-1", "Q9Y5B8-1", "O00444-1", "P17612-1", "P49674-1", "P07900-1", "P51955-1", "P68363-1", "P06493-1", "P53350-1", "Q6PEY2-1", "P68366-1", "Q71U36-1", "A6NHL2-1", "Q9NY65-1", "Q9BQE3-1", "Q9H853-1", "P0DPH8-1" ], "evidence": [ { "id": "R-HSA-380316", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-380316" } ] }, { "id": "R-HSA-380455", "name": "Recruitment of CDK11p58 to the centrosomes", "equation": "", "summary": "CDK11p58 is a kinase that is active during mitosis when it associates with centrosomes, and has a crucial role in centrosome maturation and bipolar spindle formation (Petretti et al., 2006). CDK11p58 facilitates microtubule nucleation and is required for the recruitment of Aurora and Plk1 to the centrosome (Petretti et al., 2006).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P48730-1", "O00444-1", "P17612-1", "P49674-1", "P07900-1", "P51955-1", "P06493-1", "P53350-1", "P21127-1", "Q9UQ88-1", "P68366-1", "Q71U36-1" ], "evidence": [ { "id": "R-HSA-380455", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-380455" } ] }, { "id": "R-HSA-380508", "name": "Translocation of NuMA to the centrosomes", "equation": "", "summary": "After the nuclear envelope breakdown, phosphorylated NuMA rapidly moves to the centrosomal region (Compton and Luo 1995, Hsu and Yeh 1996, Kotak et al. 2013).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P48730-1", "Q9Y5B8-1", "O00444-1", "P17612-1", "P49674-1", "P07900-1", "P51955-1", "P06493-1", "P53350-1", "P68366-1", "Q71U36-1" ], "evidence": [ { "id": "R-HSA-380508", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-380508" } ] }, { "id": "R-HSA-4086410", "name": "CDK1 phosphorylates BORA", "equation": "", "summary": "CDK1 phosphorylates both human and Drosophila BORA protein (Hutterer et al. 2006) on an evolutionarily conserved serine residue - S252 in human BORA (Chan et al. 2008), providing a docking site for PLK1.", "cellular_location": "cytosol", "input_participant_list": [ "R-HSA-2562607" ], "output_participant_list": [ "R-HSA-4086411" ], "enzyme_list": [ "P06493-1" ], "evidence": [ { "id": "R-HSA-4086410", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4086410" } ] }, { "id": "R-HSA-4088024", "name": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1", "equation": "", "summary": "In the G2 phase of the cell cycle, cyclin A (CCNA) and B (CCNB)-dependent kinases CDK1 and CDK2 phosphorylate FOXM1 transcription factor, increasing its transcriptional activity. Threonine residue T611 (corresponds to T596 in FOXM1B isoform) was shown to be phosphorylated by both CCNA:CDK1/2 and CCNB:CDK1 complexes and its functional relevance is best establshed (Major et al. 2004, Laoukili et al. 2008, Fu et al. 2008). CCNA:CDK1/2 may also phosphorylate FOXM1 on T600 (Laoukili et al. 2008), while CCNB:CDK1 may phosphorylate it on S693 (S678 in FOXM1B isoform) (Fu et al. 2008). The phosphorylation of FOXM1 threonine residue T611 relieves the N-terminal domain-mediated autoinhibition of FOXM1 transcriptional activity (Laoukili et al. 2008), likely enabling interaction with transcriptional co-activators (Major et al. 2004), and creates a docking site for the Polo-box domain (PBD) of PLK1 (Fu et al. 2008).", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-HSA-4088019" ], "output_participant_list": [], "enzyme_list": [ "P06493-1", "P24941-1" ], "evidence": [ { "id": "R-HSA-4088024", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4088024" } ] }, { "id": "R-HSA-5195402", "name": "CDK1 phosphorylates LPIN", "equation": "", "summary": "Lipins (LPIN1, LPIN2, LPIN3) possess several proline-directed phosphorylation sites that can be phosphorylated by CDK1 (Grimsey et al. 2008), including S106. Serine S106 in lipins is a preferred target for dephosphorylation by the evolutionarilly conserved CTDNEP1:CNEP1R1 complex (ortholog of yeast NEM1:SPO7 complex). Lipin phosphorylation regulates lipin localization, with phosphorylated lipins being soluble and dephosphorylated lipins being membrane-bound. The yeast ortholog of CDK1, CDC28, as well as human CDK1 can phosphorylate yeast lipin PAH1, inducing its dissociation from the nuclear envelope and endoplasmic reticulum membrane (Choi et al. 2011).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06493-1", "Q14693-1", "Q92539-1", "Q9BQK8-1" ], "evidence": [ { "id": "R-HSA-5195402", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5195402" } ] }, { "id": "R-HSA-5244669", "name": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments", "equation": "", "summary": "Phosphorylation of the N-termini of lamins by CDK1 (serine S23 of lamin B, serin S22 of lamin A and C) probably happens consequentially with phosphorylation of C-termini of lamins by PKC, and contributes to the depolymerization of lamin filaments and solubilization of the nuclear lamina (Ward and Kirschner 1990, Peter et al. 1990, Heald and McKeon 1990, Mall et al. 2012).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06493-1" ], "evidence": [ { "id": "R-HSA-5244669", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5244669" } ] }, { "id": "R-HSA-5617816", "name": "RAB3IP stimulates nucleotide exchange on RAB8A", "equation": "", "summary": "RAB3IP is a GEF for RAB8A, the only RAB GTPase localized in the cilium. GTP-bound RAB8A may play a role in recruiting vesicles from the Golgi to the ciliary base and is required for cilia formation (Nachury et al, 2007; Yoshimura et al, 2007; reviewed in Reiter et al, 2012).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P62491-1", "Q6IQ55-1", "P48730-1", "Q96L34-1", "O00444-1", "P17612-1", "P49674-1", "P07900-1", "P51955-1", "P06493-1", "P53350-1", "P68366-1", "Q71U36-1", "P61006-1" ], "evidence": [ { "id": "R-HSA-5617816", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5617816" } ] }, { "id": "R-HSA-5626220", "name": "C2CD3 binds the mother centriole", "equation": "", "summary": "C2 domain-containing protein 3 (C2CD3) is basal body-localized protein that is required for ciliogenesis and Hh signaling (Hoover et al, 2008; Balestra et al, 2013). C2CD3 is recruited to the centrosome in a pericentriolar material 1 protein (PCM1)- and microtubule-dependent manner and is required for the subsequent recruitment of the distal appendage proteins to the mother centriole (Tanos et al, 2013; Sillibourne et al, 2013; Ye et al, 2014; reviewed in Winey and O'Toole, 2014). The distal appendage proteins are thought to be a component of the transition fibres that anchor the basal body to the membrane at the base of the cilium and are themselves required for the recruitment of Tau-tubulin kinase 2 (TTBK2) and for docking ciliary vesicles to the mother centriole (Tanos et al, 2013; Wei et al, 2013; Joo et al, 2013; Schmidt et al, 2012; Sillibourne et al, 2013; Burke et al, 2014).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P48730-1", "O00444-1", "P17612-1", "P49674-1", "P07900-1", "P51955-1", "P06493-1", "P53350-1", "P68366-1", "Q71U36-1" ], "evidence": [ { "id": "R-HSA-5626220", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5626220" } ] }, { "id": "R-HSA-5626223", "name": "C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole", "equation": "", "summary": "C2CD3 and the centrosome component OFD1 are required for the recruitment of distal appendage proteins CEP164, CEP83/CCDC41, CEP89, FBF1 and SCLT1 to the mother centriole (Ye et al, 2014; Tang et al, 2013; Singla et al, 2010). Distal appendage proteins are believed to form part of the transition fibres that anchor the basal bodies to the actin rich cortex at the base of the emerging cilium, and are also required for the recruitment and binding of ciliary vesicles and intraflagellar transport (IFT) complexes (Tanos et al, 2013; Wei et al, 2013; Joo et al, 2010; Schmidt et al, 2012; Sillibourne et al, 2013; Ye et al, 2014; reviewed in Winey and O'Toole, 2014).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P48730-1", "O00444-1", "P17612-1", "P49674-1", "P07900-1", "P51955-1", "P06493-1", "P53350-1", "P68366-1", "Q71U36-1" ], "evidence": [ { "id": "R-HSA-5626223", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5626223" } ] }, { "id": "R-HSA-5626227", "name": "CP110 and CEP97 dissociate from the centriole", "equation": "", "summary": "CCP110 is a negative regulator of ciliogenesis that caps the mother centriole. CCP110 may inhibit ciliogenesis in part by preventing the CEP290-dependent recruitment of RAB8A to the centrosome and cilia (Spektor et al, 2007; Tsang et al, 2008; reviewed in Tsang and Dynlacht, 2013). CCP110 and CEP97 also form a complex with the KIF24, a kinesin with centriolar microtubule depolymerizing activity that is required for the initial recruitment and/or stability of CCP110 at the centriole (Kobayashi et al, 2011). Recruitment of TTBK2 promotes the displacement of CCP110 and its binding partner CEP97. This results in the formation of a basal body and promotes recruitment of IFT complex members and allows axonemal extension to occur (Goetz et al, 2012; Ye et al, 2014; reviewed in Tsang and Dynlacht, 2013). Although the kinase activity of TTBK2 is required for cilium formation and TTBK2 has been shown to phosphorylate CEP164, the relevant physiological target during ciliogenesis has not been unambiguously identified (Cajanek et al, 2014). Similarly, the kinase activity of MARK4 is also required for ciliogenesis, and the interaction between MARK4 and ODF2, a putative substrate, is needed to promote the dissociation of the CCP110 and CEP97 proteins from the centriole (Kuhns et al, 2013; reviewed in Kim and Dynlacht, 2013).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6IQ55-1", "P48730-1", "Q96L34-1", "O00444-1", "P17612-1", "P49674-1", "P07900-1", "P51955-1", "P06493-1", "P53350-1", "P68366-1", "Q71U36-1" ], "evidence": [ { "id": "R-HSA-5626227", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5626227" } ] }, { "id": "R-HSA-5626228", "name": "The distal appendage proteins recruit TTBK2", "equation": "", "summary": "C2CD3 and the distal appendage protein CEP164 are required for the recruitment of the kinase Tau tubulin kinase 2 (TTBK2) to the centriole (Ye et al, 2014; Cajanek et al, 2014). TTBK2 recruitment promotes the release of CCP110, a negative regulator of ciliogenesis that caps the mother centriole (Goetz et al, 2012; Ye et al, 2014; Tsang et al, 2008; Spektor et al, 2007). CCP110 is initially recruited and/or stabilized at the mother centriole in a KIF24-dependent manner; KIF24, a kinesin-like protein, also restricts ciliogenesis through its microtubule depolymerizing activity (Kobayashi et al, 2011). In addition to promoting the release of CCP110, TTBK2 also plays a role in the recruitment of intraflagellar transport (IFT) proteins and in this way contributes to extension of the ciliary axoneme (Goetz et al, 2012; Ye et al, 2014). Mutations in TTBK2 disrupt ciliogenesis and are associated with the development of spinocerebellar ataxia (Houlden et al, 2007; Bouskila et al, 2011; reviewed in Jackson, 2012).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6IQ55-1", "P48730-1", "O00444-1", "P17612-1", "P49674-1", "P07900-1", "P51955-1", "P06493-1", "P53350-1", "P68366-1", "Q71U36-1" ], "evidence": [ { "id": "R-HSA-5626228", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5626228" } ] }, { "id": "R-HSA-5626681", "name": "Recruitment of transition zone proteins", "equation": "", "summary": "The transition zone is a protein-rich zone at the base of the cilium that forms after maturation of the mother centriole and prior to or concurrent with the initiation of intraflagellar transport (IFT) (reviewed in Benzing and Schermer, 2011; Reiter et al, 2012). The transition zone consists of a growing number of proteins and protein complexes, many of whose genes are associated with ciliopathies such as nephronophthisis, Meckel-Gruber syndrome and Joubert's syndrome (Reiter et al, 2006; Hu et al, 2010; Sang et al, 2011; Williams et al, 2011; Garcia-Gonzalo et al, 2011; Chih et al, 2012; reviewed in Reiter et al, 2012). In conjunction with SEPT2, which was recently shown to form a septin ring diffusion barrier at the base of the cilium, the transition zone and its resident proteins contribute to protein sorting and ciliary membrane composition and act as a ciliary gate (Hu et al, 2010; Williams et al, 2011; Garcia-Gonzalo et al, 2011; Chih et al, 2012; reviewed in Reiter et al, 2012).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6IQ55-1", "P48730-1", "Q96L34-1", "O00444-1", "P17612-1", "P49674-1", "P07900-1", "P51955-1", "P06493-1", "P53350-1", "P68366-1", "Q71U36-1" ], "evidence": [ { "id": "R-HSA-5626681", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5626681" } ] }, { "id": "R-HSA-5626699", "name": "MARK4 binds ODF2 in the centriole", "equation": "", "summary": "MARK4 (microtubule associated protein/microtubule affinity regulating kinase 4) was identified in a screen as a positive regulator of ciliogenesis (Kuhns et al, 2013). MARK4 interacts at the centriole with the subdistal appendage component ODF2 and this interaction is required to promote axonemal extension (Kuhns et al, 2013; reviewed in Kim and Dynlacht, 2013). Like Tau tubulin kinase 2 (TTBK2), MARK4 appears to have a role in promoting the dissociation of CCP110 and CEP97, uncapping the centriole and allowing axonemal extension to take place (Kuhns et al, 2013; Ye et al, 2014;; Goetz et al, 2012). Although this reaction shows that MARK4 is recruited to the centriole subsequent to TTBK2, the timing of the ODF2:MARK4 interaction is not known.", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6IQ55-1", "P48730-1", "Q96L34-1", "O00444-1", "P17612-1", "P49674-1", "P07900-1", "P51955-1", "P06493-1", "P53350-1", "P68366-1", "Q71U36-1" ], "evidence": [ { "id": "R-HSA-5626699", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5626699" } ] }, { "id": "R-HSA-5638009", "name": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body", "equation": "", "summary": "The distal appendage protein CEP164 interacts with RAB3IP, and in this way recruits Golgi-derived vesicles to the basal body to initiate ciliary membrane biogenesis (Schmidt et al, 2012; Westlake et al, 2011; Rohatgi and Snell, 2010). RAB3IP recruitment to the distal appendages of centrioles promotes the appropriate localization and activation of RAB8A (Nachury et al, 2007; Yoshimura et al, 2007; Westlake et al, 2011; Schmidt et al, 2012).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P62491-1", "Q6IQ55-1", "P48730-1", "Q96L34-1", "O00444-1", "P17612-1", "P49674-1", "P07900-1", "P51955-1", "P06493-1", "P53350-1", "P68366-1", "Q71U36-1" ], "evidence": [ { "id": "R-HSA-5638009", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5638009" } ] }, { "id": "R-HSA-5692755", "name": "CDK1 phosphorylates MAPK6", "equation": "", "summary": "MAPK6 is hyperphosphorylated by CDK1 at multiple sites in the C-terminal extension, and this phosphorylation is associated with the stabilization of MAPK6 protein in mitosis. Residues S684, S688, T698 and S705 have been identified as in vitro targets of CDK1, and phosphorylation of T698 has also been demonstrated in vivo (Tanguay et al, 2010). The role of hyperphosphorylated MAPK6 during mitosis has not been established, and although the CDK1-dependent phosphorylation of MAPK6 is depicted as occuring in the nucleus, the site of action has also not been determined. CDK1-dependent hyperphosphorylation of the C-terminal tail is reversed by the phosphatases CDC14A and B (Tanguay et al, 2010; Hansen et al, 2008).", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-HSA-5692686" ], "output_participant_list": [ "R-HSA-5692665" ], "enzyme_list": [ "P06493-1", "Q16659-1" ], "evidence": [ { "id": "R-HSA-5692755", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5692755" } ] }, { "id": "R-HSA-6793661", "name": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218", "equation": "", "summary": "CDK1 or CDK2 in complex with CCNA (cyclin A) phosphorylates MDM2 at threonine residue T218. Phosphorylation of MDM2 at T218 increases its affinity for p14-ARF and reduces its affinity for TP53 (p53), thus resulting in TP53 upregulation (Zhang and Prives 2001).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [ "R-HSA-6792862" ], "enzyme_list": [ "Q00987-1", "P06493-1", "P24941-1" ], "evidence": [ { "id": "R-HSA-6793661", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6793661" } ] }, { "id": "R-HSA-6803875", "name": "SFN dimer binds CDK1 and CCNB1", "equation": "", "summary": "SFN (14-3-3-sigma) dimer binds the complex of CCNB1 (cyclin B1) and CDK1 (Cdc2) in the cytosol and prevents the translocation of the CCNB1:CDK1 complex into the nucleus. This induces G2 cell cycle arrest as nuclear localization of the CCNB1:CDK1 complex is necessary for phosphorylation of nuclear target proteins that are needed for the G2/M transition (Chan et al. 1999).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06493-1" ], "evidence": [ { "id": "R-HSA-6803875", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803875" } ] }, { "id": "R-HSA-69754", "name": "Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes", "equation": "", "summary": "At the beginning of this reaction, 1 molecule of 'ATP', and 1 molecule of 'G2/M transition protein' are present. At the end of this reaction, 1 molecule of 'ADP', and 1 molecule of 'phospho-G2/M transition protein' are present.

This reaction takes place in the 'nucleoplasm' and is mediated by the 'cyclin-dependent protein kinase activity' of 'Cyclin A1:Cdc2' (Liu et al. 2000).
", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-HSA-617370" ], "output_participant_list": [ "R-HSA-617372" ], "enzyme_list": [ "P06493-1" ], "evidence": [ { "id": "R-HSA-69754", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-69754" } ] }, { "id": "R-HSA-69756", "name": "Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes", "equation": "", "summary": "At the beginning of this reaction, 1 molecule of 'ATP', and 1 molecule of 'G2/M transition protein' are present. At the end of this reaction, 1 molecule of 'ADP', and 1 molecule of 'phospho-G2/M transition protein' are present.

This reaction takes place in the 'nucleoplasm' and is mediated by the 'cyclin-dependent protein kinase activity' of 'Cyclin A2:Cdc2'.
", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-HSA-617374" ], "output_participant_list": [ "R-HSA-617371", "R-HSA-69753" ], "enzyme_list": [ "P06493-1" ], "evidence": [ { "id": "R-HSA-69756", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-69756" } ] }, { "id": "R-HSA-8852306", "name": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends", "equation": "", "summary": "Starting in mitotic prometaphase, GTSE1 becomes phosphorylated at threonine residues T513 and T526 (and possibly other sites), located adjacent to the two SKIP-like motifs involved in binding to MAPRE1 (EB1). Mitotic phosphorylation of GTSE1 inhibits its association with microtubule plus ends. CDK1 activity inhibits the association of recombinant human GTSE1 with microtubule plus ends in Xenopus extracts, but it is not certain whether CDK1 or another mitotic kinase phosphorylates GTSE1 (Scolz et al. 2012).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-HSA-8852308" ], "enzyme_list": [ "P0DPH7-1", "P68363-1", "P06493-1", "Q6PEY2-1", "P68366-1", "Q71U36-1", "A6NHL2-1", "Q9NY65-1", "Q9BQE3-1", "Q9H853-1", "P0DPH8-1" ], "evidence": [ { "id": "R-HSA-8852306", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8852306" } ] }, { "id": "R-HSA-8853405", "name": "TPX2 binds AURKA at centrosomes", "equation": "", "summary": "TPX2 binds to aurora kinase A (AURKA) at centrosomes. The first 43 amino acids at the N-terminus of TPX2 are needed for binding to AURKA (Bayliss et al. 2003). HMMR (RHAMM) binds to TPX2 (Groen et al. 2004, Maxwell et al. 2005) and is involved in the proper localization of TPX2 to centrosomes and TPX2-mediated AURKA activation (Chen et al. 2014, Scrofani et al. 2015).

TPX2 binding to Aurora A protects premature AURKA degradation by APC/C-mediated proteolysis during early mitosis. TPX2 differentially regulates AURKA stability, activity and localization. While amino acids 1-43 in TPX2 facilitate complex formation between AURKA and TPX2 and promote kinase activation, they are insufficient for AURKA targeting to the mitotic spindle (Giubettini et al. 2011).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P48730-1", "O00444-1", "P17612-1", "P49674-1", "P07900-1", "P51955-1", "O14965-1", "P06493-1", "P53350-1", "P68366-1", "Q71U36-1" ], "evidence": [ { "id": "R-HSA-8853405", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853405" } ] }, { "id": "R-HSA-8853419", "name": "TPX2 promotes AURKA autophosphorylation", "equation": "", "summary": "TPX2 promotes aurora kinase A (AURKA) activation via autophosphorylation of AURKA on threonine residue T288. Continuous association of TPX2 with AURKA facilitates active state conformation of AURKA and may prevent inactivation of AURKA by protein phosphatases (Bayliss et al. 2003).

Molecular dynamic simulations suggest the existence of two TPX2-dependent switches for Aurora A activation. 1) TPX2 binding to Aurora A forces lysine residue K143 of AURKA into an \u201copen\u201d state, which pulls ADP out of the ATP binding site in AURKA to promote kinase activation. 2) Arginine residue R180 of AURKA undergoes a \u201cclosed\u201d movement upon TPX2 binding, thus capturing phosphorylated threonine T288 of AURKA into a buried position and locking AURKA in its active conformation. The existence of two TPX2-dependent switches in AURKA activation was further verified by the analysis of two AURKA mutants (K143A and R180A) (Xu et al. 2011).AURKA activation is enabled through phosphorylation and TPX2 binding; these two activating switches act synergistically and withough a predefined order (Dodson and Bayliss 2012).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P48730-1", "O00444-1", "P17612-1", "P49674-1", "P07900-1", "P51955-1", "O14965-1", "P06493-1", "P53350-1", "P68366-1", "Q71U36-1" ], "evidence": [ { "id": "R-HSA-8853419", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853419" } ] }, { "id": "R-HSA-8940100", "name": "CDK1 phosphorylates VCPIP1", "equation": "", "summary": "Valosin-containing protein p97/p47 complex-interacting protein 1 (VCPIP1, VCIP135) enzymatic activity is required for p97/p47 (VCP/NSFL1C) -mediated Golgi membrane fusion (Wang et al. 2004). In vitro it displays highest activity toward K11- and K48-linked ubiquitin chains (Mevissen et al. 2013, Zhang & Wang 2015).

VCPIP1 is highly phosphorylated in mitosis. This reduces its association with Golgi membranes and its interaction with VCP and is thought to regulate VCP function in the fusion of the postmitotic Golgi membrane (Zhang et al. 2014).

The N-terminal half of VCPIP1 has a single phosphorylation site, S131 (Zhang et al. 2014). A S131A mutant (serine mutated to alanine) exhibited strong DUB activity, while a phosphomimetic S131E (serine mutated to glutamic acid) mutant had no detectable activity suggesting that S131 phosphorylation regulates VCPIP1 DUB activity. Phosphorylation of VCPIP1 by CDK1 at S131 was sufficient to inactivate the enzyme and inhibit p97/p47-mediated Golgi membrane fusion. Dephosphorylation of VCPIP1 with the CDK1 inhibitor roscovitine significantly increased the DUB activity of endogenous VCPIP1 and attenuated p97/p47-mediated Golgi membrane fusion (Zhang & Wang 2015).", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [ "R-HSA-8940103" ], "output_participant_list": [ "R-HSA-8940104" ], "enzyme_list": [ "Q96JH7-1", "P06493-1" ], "evidence": [ { "id": "R-HSA-8940100", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8940100" } ] }, { "id": "R-HSA-8961934", "name": "CDK1 gene expression is stimulated by E2F1 and repressed by RBL1 and RBL2", "equation": "", "summary": "E2F1 directly stimulates transcription of the CDK1 gene, encoding cyclin-dependent kinase 1 (Cdc2) (Furukawa et al. 1994, DeGregori et al. 1995, Zhu et al. 2004). Transcription of the CDK1 gene is directly inhibited by complexes of HDAC1 and RBL1 (p107) or RBL2 (p130) in G1 and G0, respectively (Rayman et al. 2002).", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-HSA-8961921" ], "output_participant_list": [ "R-HSA-68889" ], "enzyme_list": [ "Q13547-1", "P06493-1" ], "evidence": [ { "id": "R-HSA-8961934", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8961934" } ] }, { "id": "R-HSA-9009282", "name": "CDK1 phosphorylates RUNX2", "equation": "", "summary": "RUNX2, presumably in complex with CBFB, can be phosphorylated by the complex of CDK1 and cyclin B. The interaction was demonstrated between endogenous human RUNX2 and CDK1:CCNB1. It was also shown in human cells that RUNX2 undergoes CDK1:CCNB1-mediated phosphorylation on serine residue S451 of RUNX2-P2 isoform. This residue corresponds to the mouse Runx-P1 serine residue S472 (Qiao et al. 2006, Rajgopal et al. 2007). At mitotic exit, RUNX2 is dephosphorylated by unidentified PP1 or PP2A phosphatase (Rajgopal et al. 2007).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06493-1" ], "evidence": [ { "id": "R-HSA-9009282", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9009282" } ] }, { "id": "R-HSA-9624800", "name": "CDK1 phosphorylates LBR", "equation": "", "summary": "During mitosis, CDK1 phosphorylates LBR (lamin B receptor) on N-terminal serine residues S71 and S86. S71 is the major CDK1 phosphorylation site in LBR (Tseng and Chen 2011).", "cellular_location": "cytosol, nuclear envelope", "input_participant_list": [ "R-HSA-194637" ], "output_participant_list": [ "R-HSA-9624811" ], "enzyme_list": [ "P06493-1", "Q14739-1" ], "evidence": [ { "id": "R-HSA-9624800", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9624800" } ] }, { "id": "R-HSA-9836184", "name": "p-PKR dimer phosphorylates CDK1", "equation": "", "summary": "Cyclin-dependent kinase 1 (CDK1, CDC2), as subunit of a complex with Cyclin B, regulates and promotes multiple transitions in the cell cycle. Protein kinase R (PKR, EIF2AK2) phosphorylates CDK1 at Y4, marking it for subsequent ubiquitination and proteosomal degradation, leading to G2/M arrest and apoptosis, in particular under genotoxic conditions in cancer therapy, and as part of the antiviral response (Dagon et al, 2001; Yoon et al, 2010).", "cellular_location": "cytosol", "input_participant_list": [ "R-HSA-170075" ], "output_participant_list": [ "R-HSA-9836187" ], "enzyme_list": [ "P06493-1", "P19525-1" ], "evidence": [ { "id": "R-HSA-9836184", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9836184" } ] }, { "id": "R-NUL-2422970", "name": "Phosphorylation of Gorasp1, Golga2 and RAB1A by CDK1:CCNB", "equation": "", "summary": "The existence of Gorasp1:Golga2:Uso1:Rab1:GTP complex was established by co-immunoprecipitation of exogenously expressed human RAB1A (identical sequence to rat Rab1A) from normal rat kidney cells, NRKs (Moyer et al. 2001). It was also shown that human RAB1B binds human GM130 (Weide et al. 2001). In mitotic prophase, human CDK1 (CDC2) in complex with either CCNB1 (cyclin B1) or CCNB2 (cyclin B2), as both CCNB1 and CCNB2 can localize to Golgi (Jackman et al. 1995, Draviam et al. 2001), was shown to phosphorylate recombinant rat Gorasp1 and Golga2, as well as RAB1A (Bailly et al. 1991, Lowe et al. 1998, Preisinger et al. 2005) . Phosphorylation of Golga2 and RAB1A impairs their association with Uso1 (Lowe et al. 1998, Seeman et al. 2000, Moyer et al. 2001).", "cellular_location": "Golgi membrane, cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P06493-1", "P62820-1", "Q9H0U4-1" ], "evidence": [ { "id": "R-NUL-2422970", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-NUL-2422970" } ] }, { "id": "R-NUL-2434198", "name": "CDK1 phosphorylates Mastl", "equation": "", "summary": "Phosphorylation of MASTL (GWL) by CDK1 (Cdc2) was established using Mastl (Gwl) purified from Xenopus egg extracts and recombinant human CDK1. Phosphopeptide mapping identified several CDK1 phosphorylation sites in Mastl of which threonine residues T193 (Blake-Hodek et al. 2012), T206 (Blake-Hodek et al. 2012) and T748 (Yu et al. 2006) were found to be functionally important. These threonine residues are conserved and they correspond to T194, T207 and T741 of human MASTL. In addition, phosphorylation of Xenopus Mastl on serines S101 and S883 is important for the mitotic function of Mastl, but these sites, although conserved in Xenopus, human and mouse, do not conform to the CDK1 consensus, and the responsible kinase has not been identified. S883 may represent an autophosphorylation site (Blake-Hodek et al. 2012).", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-XLA-2434201" ], "output_participant_list": [ "R-XLA-2434203" ], "enzyme_list": [ "P06493-1" ], "evidence": [ { "id": "R-NUL-2434198", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-NUL-2434198" } ] } ], "reaction_participants": [ { "participant_id": "R-HSA-157456", "participant_name": "CCNB1:p-T161-CDK1 [cytosol]", "crossref": [ { "id": "CPX-2007", "database": "ComplexPortal", "url": "" } ] }, { "participant_id": "R-HSA-1638143", "participant_name": "Condensin I [cytosol]", "crossref": [ { "id": "CPX-979", "database": "ComplexPortal", "url": "" } ] }, { "participant_id": "R-HSA-170047", "participant_name": "phospho-cyclin B1(CRS):phosph-Cdc2(Thr 161) [cytosol]", "crossref": [ { "id": "CPX-2007", "database": "ComplexPortal", "url": "" } ] }, { "participant_id": "R-HSA-170056", "participant_name": "CCNB1:p-T14-CDK1 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"id": "A0A0G2JZW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JZW9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A0G2JZW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JZW9" } ] } ] }, { "uniprot_ac": "A0A0G2K2T8", "gene_name": "RGD1565143", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A0G2K2T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K2T8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A0G2K2T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K2T8" } ] } ] }, { "uniprot_ac": "A0A0G2K344", "gene_name": "Pik3ca", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A0G2K344", "database": "UniProtKB", "url": 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} ] } ] }, { "uniprot_ac": "A0A0G2K490", "gene_name": "Tnik", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A0G2K490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K490" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A0G2K490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K490" } ] } ] }, { "uniprot_ac": "A0A0G2K578", "gene_name": "AABR07068650.1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A0G2K578", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K578" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A0G2K578", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K578" } ] } ] }, { "uniprot_ac": "A0A0G2K5C7", "gene_name": "Nek1", 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L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A0G2K6V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K6V9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A0G2K6V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K6V9" } ] } ] }, { "uniprot_ac": "A0A0G2KAH6", "gene_name": "Srpk3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A0G2KAH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2KAH6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A0G2KAH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2KAH6" } ] } ] }, { "uniprot_ac": "A0A0G2KB60", "gene_name": "Rps6kc1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A0G2KB60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2KB60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A0G2KB60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2KB60" } ] } ] }, { "uniprot_ac": "A0A0G2QC55", "gene_name": "Tssk4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A0G2QC55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2QC55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A0G2QC55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2QC55" } ] } ] }, { "uniprot_ac": "A0A140LI04", "gene_name": "Gm5890", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A140LI04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A140LI04" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A140LI04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A140LI04" } ] } ] }, { "uniprot_ac": "A0A140LJ87", "gene_name": "Gm4565", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A140LJ87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A140LJ87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A140LJ87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A140LJ87" } ] } ] }, { "uniprot_ac": "A0A3B2WD63", "gene_name": "Gm7356", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A3B2WD63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A3B2WD63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3B2WD63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A3B2WD63" } ] } ] }, { "uniprot_ac": "A0A4D6K823", "gene_name": "nmo", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A4D6K823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A4D6K823" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A4D6K823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A4D6K823" } ] } ] }, { "uniprot_ac": "A0A6M3Q7C8", "gene_name": "SRPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A6M3Q7C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A6M3Q7C8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A6M3Q7C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A6M3Q7C8" } ] } ] }, { "uniprot_ac": "A0A8I5Y7S3", "gene_name": "LOC120097771", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I5Y7S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5Y7S3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I5Y7S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5Y7S3" } ] } ] }, { "uniprot_ac": "A0A8I5Y8C3", "gene_name": "Stk36", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I5Y8C3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5Y8C3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I5Y8C3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5Y8C3" } ] } ] }, { "uniprot_ac": "A0A8I5ZKJ9", "gene_name": "ENSRNOG00000070867", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I5ZKJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZKJ9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I5ZKJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZKJ9" } ] } ] }, { "uniprot_ac": "A0A8I5ZLV4", "gene_name": "Map4k4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I5ZLV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZLV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I5ZLV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZLV4" } ] } ] }, { "uniprot_ac": "A0A8I5ZMP0", "gene_name": "Mast2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I5ZMP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMP0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I5ZMP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMP0" } ] } ] }, { "uniprot_ac": "A0A8I5ZN46", "gene_name": "LOC108353138", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I5ZN46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZN46" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I5ZN46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZN46" } ] } ] }, { "uniprot_ac": "A0A8I5ZNK2", "gene_name": "Oxsr1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I5ZNK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZNK2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I5ZNK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZNK2" } ] } ] }, { "uniprot_ac": "A0A8I5ZP97", "gene_name": "Dyrk1b", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I5ZP97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZP97" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A8I5ZP97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZP97" } ] } ] }, { "uniprot_ac": "A0A8I5ZR62", "gene_name": "RGD1565071", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I5ZR62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZR62" } ] }, { "ec_number": "2.7.11.31", "activity": "ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase].", "evidence": [ { "id": "A0A8I5ZR62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZR62" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0A8I5ZR62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZR62" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I5ZR62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZR62" } ] } ] }, { "uniprot_ac": "A0A8I5ZS27", "gene_name": "LOC102555239", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I5ZS27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZS27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I5ZS27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZS27" } ] } ] }, { "uniprot_ac": "A0A8I5ZSS7", "gene_name": "LOC102546375", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I5ZSS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZSS7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I5ZSS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZSS7" } ] } ] }, { "uniprot_ac": "A0A8I5ZT61", "gene_name": "LOC300308", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I5ZT61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZT61" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I5ZT61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZT61" } ] } ] }, { "uniprot_ac": "A0A8I5ZUS1", "gene_name": "Map3k4", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I5ZUS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUS1" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A8I5ZUS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUS1" } ] } ] }, { "uniprot_ac": "A0A8I5ZUX6", "gene_name": "RGD1566007", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I5ZUX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUX6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I5ZUX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUX6" } ] } ] }, { "uniprot_ac": "A0A8I5ZV60", "gene_name": "Hunk", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I5ZV60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZV60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I5ZV60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZV60" } ] } ] }, { "uniprot_ac": "A0A8I5ZYM4", "gene_name": "Cdk8", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I5ZYM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZYM4" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "A0A8I5ZYM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZYM4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A8I5ZYM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZYM4" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A8I5ZYM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZYM4" } ] } ] }, { "uniprot_ac": "A0A8I5ZZZ6", "gene_name": "Riok3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I5ZZZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZZZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I5ZZZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZZZ6" } ] } ] }, { "uniprot_ac": "A0A8I6A0F8", "gene_name": "Stk4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6A0F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A0F8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6A0F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A0F8" } ] } ] }, { "uniprot_ac": "A0A8I6A165", "gene_name": "LOC120093114", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6A165", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A165" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6A165", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A165" } ] } ] }, { "uniprot_ac": "A0A8I6A1U5", "gene_name": "LOC120093094", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6A1U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A1U5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6A1U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A1U5" } ] } ] }, { "uniprot_ac": "A0A8I6A574", "gene_name": "Nek4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6A574", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A574" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6A574", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A574" } ] } ] }, { "uniprot_ac": "A0A8I6A7D1", "gene_name": "Rps6ka5", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6A7D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A7D1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6A7D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A7D1" } ] } ] }, { "uniprot_ac": "A0A8I6A7V5", "gene_name": "Cdk14", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6A7V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A7V5" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A8I6A7V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A7V5" } ] } ] }, { "uniprot_ac": "A0A8I6A8U4", "gene_name": "ENSRNOG00000066428", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6A8U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A8U4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6A8U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A8U4" } ] } ] }, { "uniprot_ac": "A0A8I6A9X0", "gene_name": "LOC120100104", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6A9X0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A9X0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6A9X0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A9X0" } ] } ] }, { "uniprot_ac": "A0A8I6AAX5", "gene_name": "LOC120099682", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6AAX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AAX5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6AAX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AAX5" } ] } ] }, { "uniprot_ac": "A0A8I6ACE8", "gene_name": "LOC100910657", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6ACE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6ACE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6ACE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6ACE8" } ] } ] }, { "uniprot_ac": "A0A8I6ACR1", "gene_name": "ENSRNOG00000067256", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6ACR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6ACR1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6ACR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6ACR1" } ] } ] }, { "uniprot_ac": "A0A8I6AD01", "gene_name": "Rps6kl1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6AD01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AD01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6AD01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AD01" } ] } ] }, { "uniprot_ac": "A0A8I6AEL0", "gene_name": "Map3k5", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6AEL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AEL0" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A8I6AEL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AEL0" } ] } ] }, { "uniprot_ac": "A0A8I6AHQ6", "gene_name": "Nek2l1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6AHQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AHQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6AHQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AHQ6" } ] } ] }, { "uniprot_ac": "A0A8I6AJD2", "gene_name": "LOC103690174", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6AJD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AJD2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6AJD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AJD2" } ] } ] }, { "uniprot_ac": "A0A8I6AJX5", "gene_name": "RGD1561440", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6AJX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AJX5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A8I6AJX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AJX5" } ] } ] }, { "uniprot_ac": "A0A8I6ANX6", "gene_name": "Dmpk", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6ANX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6ANX6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6ANX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6ANX6" } ] } ] }, { "uniprot_ac": "A0A8I6AQN6", "gene_name": "Rps6ka6", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6AQN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AQN6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6AQN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AQN6" } ] } ] }, { "uniprot_ac": "A0A8I6ATH0", "gene_name": "Braf", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6ATH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6ATH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6ATH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6ATH0" } ] } ] }, { "uniprot_ac": "A0A8I6ATM1", "gene_name": "Prkg1", "activity": [ { "ec_number": "2.7.11.12", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6ATM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6ATM1" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0A8I6ATM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6ATM1" } ] } ] }, { "uniprot_ac": "A0A8I6AUJ4", "gene_name": "Mast4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6AUJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AUJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6AUJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AUJ4" } ] } ] }, { "uniprot_ac": "A0A8I6AWX7", "gene_name": "Dyrk4", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6AWX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AWX7" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A8I6AWX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AWX7" } ] } ] }, { "uniprot_ac": "A0A8I6G1H3", "gene_name": "Irak4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6G1H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6G1H3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6G1H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6G1H3" } ] } ] }, { "uniprot_ac": "A0A8I6G5Z0", "gene_name": "AABR07072539.5", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6G5Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6G5Z0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6G5Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6G5Z0" } ] } ] }, { "uniprot_ac": "A0A8I6G980", "gene_name": "LOC100911984", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6G980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6G980" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6G980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6G980" } ] } ] }, { "uniprot_ac": "A0A8I6GBQ0", "gene_name": "Stk26", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6GBQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GBQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6GBQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GBQ0" } ] } ] }, { "uniprot_ac": "A0A8I6GDY5", "gene_name": "RGD1564651", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6GDY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GDY5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6GDY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GDY5" } ] } ] }, { "uniprot_ac": "A0A8I6GI15", "gene_name": "RGD1560718", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6GI15", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GI15" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6GI15", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GI15" } ] } ] }, { "uniprot_ac": "A0A8I6GJV1", "gene_name": "ENSRNOG00000069390", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6GJV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GJV1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6GJV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GJV1" } ] } ] }, { "uniprot_ac": "A0A8I6GK16", "gene_name": "LOC102549716", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6GK16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GK16" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6GK16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GK16" } ] } ] }, { "uniprot_ac": "A0A8I6GK52", "gene_name": "Smg1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6GK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6GK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GK52" } ] } ] }, { "uniprot_ac": "A0A8I6GKS8", "gene_name": "LOC120093063", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6GKS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GKS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6GKS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GKS8" } ] } ] }, { "uniprot_ac": "A0A8I6GM03", "gene_name": "LOC685793", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6GM03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GM03" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6GM03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GM03" } ] } ] }, { "uniprot_ac": "A0A8J8XEH6", "gene_name": "ENSRNOG00000067334", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8J8XEH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8J8XEH6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8J8XEH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8J8XEH6" } ] } ] }, { "uniprot_ac": "A0AUV4", "gene_name": "Gm7168", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0AUV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0AUV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AUV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0AUV4" } ] } ] }, { "uniprot_ac": "A1A5Q6", "gene_name": "Smok", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A1A5Q6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1A5Q6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A1A5Q6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1A5Q6" } ] } ] }, { "uniprot_ac": "A1Z7T0", "gene_name": "Pkn", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A1Z7T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1Z7T0" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1Z7T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1Z7T0" } ] }, { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "A1Z7T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1Z7T0" } ] } ] }, { "uniprot_ac": "A1Z9X0", "gene_name": "aPKC", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A1Z9X0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1Z9X0" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1Z9X0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1Z9X0" } ] } ] }, { "uniprot_ac": "A1ZBC4", "gene_name": "Sik3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A1ZBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1ZBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A1ZBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1ZBC4" } ] }, { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "A1ZBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1ZBC4" } ] } ] }, { "uniprot_ac": "A1ZBH7", "gene_name": "hppy", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A1ZBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1ZBH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A1ZBH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1ZBH7" } ] } ] }, { "uniprot_ac": "A1ZBL9", "gene_name": "par-1", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "A1ZBL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1ZBL9" } ] }, { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "A1ZBL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1ZBL9" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A1ZBL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1ZBL9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A1ZBL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1ZBL9" } ] } ] }, { "uniprot_ac": "A2AAJ9", "gene_name": "Obscn", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A2AAJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AAJ9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2AAJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AAJ9" } ] } ] }, { "uniprot_ac": "A2AQW0", "gene_name": "Map3k15", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A2AQW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AQW0" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2AQW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AQW0" } ] } ] }, { "uniprot_ac": "A2AQX6", "gene_name": "Gm14151", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A2AQX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AQX6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2AQX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AQX6" } ] } ] }, { "uniprot_ac": "A2ASS6", "gene_name": "Ttn", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A2ASS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ASS6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2ASS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ASS6" } ] } ] }, { "uniprot_ac": "A2CG49", "gene_name": "Kalrn", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A2CG49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2CG49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2CG49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2CG49" } ] } ] }, { "uniprot_ac": "A2KF29", "gene_name": "Smoktcr", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A2KF29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2KF29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2KF29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2KF29" } ] } ] }, { "uniprot_ac": "A4L9P5", "gene_name": "Hipk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A4L9P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A4L9P5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A4L9P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A4L9P5" } ] } ] }, { "uniprot_ac": "A4VCL2", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A4VCL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A4VCL2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A4VCL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A4VCL2" } ] } ] }, { "uniprot_ac": "A5LHX3", "gene_name": "PSMB11", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "A5LHX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A5LHX3" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "A5LHX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A5LHX3" } ] } ] }, { "uniprot_ac": "A6HK01", "gene_name": "Map3k3", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A6HK01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6HK01" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A6HK01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6HK01" } ] } ] }, { "uniprot_ac": "A6KB61", "gene_name": "Riok2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A6KB61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6KB61" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A6KB61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6KB61" } ] } ] }, { "uniprot_ac": "A6NHL2", "gene_name": "TUBAL3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6NHL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NHL2" } ] } ] }, { "uniprot_ac": "B0G126", "gene_name": "pip5k3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "B0G126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G126" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "B0G126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G126" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "B0G126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G126" } ] } ] }, { "uniprot_ac": "B0LT89", "gene_name": "Stk24", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "B0LT89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0LT89" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "B0LT89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0LT89" } ] } ] }, { "uniprot_ac": "B1WBT4", "gene_name": "Srpk2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "B1WBT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1WBT4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "B1WBT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1WBT4" } ] } ] }, { "uniprot_ac": "B1WBU5", "gene_name": "Sbk2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "B1WBU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1WBU5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "B1WBU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1WBU5" } ] } ] }, { "uniprot_ac": "B2DD29", "gene_name": "Brsk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "B2DD29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2DD29" } ] }, { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "B2DD29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2DD29" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "B2DD29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2DD29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "B2DD29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2DD29" } ] } ] }, { "uniprot_ac": "B2GUY1", "gene_name": "Plk4", "activity": [ { "ec_number": "2.7.11.21", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "B2GUY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GUY1" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "B2GUY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GUY1" } ] } ] }, { "uniprot_ac": "B5DFG1", "gene_name": "Pink1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "B5DFG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DFG1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "B5DFG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DFG1" } ] } ] }, { "uniprot_ac": "C0HKC8", "gene_name": "Smok3a", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "C0HKC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C0HKC8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "C0HKC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C0HKC8" } ] } ] }, { "uniprot_ac": "C0HKC9", "gene_name": "Smok3b", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "C0HKC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C0HKC9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "C0HKC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C0HKC9" } ] } ] }, { "uniprot_ac": "D3Z822", "gene_name": "Atr", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3Z822", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z822" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D3Z822", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z822" } ] } ] }, { "uniprot_ac": "D3Z837", "gene_name": "Cdc42bpg", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3Z837", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z837" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D3Z837", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z837" } ] } ] }, { "uniprot_ac": "D3Z8E0", "gene_name": "Rps6ka3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3Z8E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z8E0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D3Z8E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z8E0" } ] } ] }, { "uniprot_ac": "D3Z8I4", "gene_name": "Map4k1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3Z8I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z8I4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D3Z8I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z8I4" } ] } ] }, { "uniprot_ac": "D3ZBE5", "gene_name": "Nek7", "activity": [ { "ec_number": "2.7.11.34", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3ZBE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBE5" } ] }, { "ec_number": "2.7.11.34", "activity": "", "evidence": [ { "id": "D3ZBE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBE5" } ] } ] }, { "uniprot_ac": "D3ZBS8", "gene_name": "LOC690235", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3ZBS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D3ZBS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBS8" } ] } ] }, { "uniprot_ac": "D3ZCD7", "gene_name": "Tp53rkb", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3ZCD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZCD7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D3ZCD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZCD7" } ] } ] }, { "uniprot_ac": "D3ZD18", "gene_name": "Stk32a", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3ZD18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD18" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D3ZD18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD18" } ] } ] }, { "uniprot_ac": "D3ZDM6", "gene_name": "Cdk19", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3ZDM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDM6" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "D3ZDM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDM6" } ] } ] }, { "uniprot_ac": "D3ZEK4", "gene_name": "Tssk6", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3ZEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEK4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D3ZEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEK4" } ] } ] }, { "uniprot_ac": "D3ZFL3", "gene_name": "Map3k6", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3ZFL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZFL3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "D3ZFL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZFL3" } ] } ] }, { "uniprot_ac": "D3ZG83", "gene_name": "Map3k10", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3ZG83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZG83" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "D3ZG83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZG83" } ] } ] }, { "uniprot_ac": "D3ZGQ5", "gene_name": "Nek8", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3ZGQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D3ZGQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGQ5" } ] } ] }, { "uniprot_ac": "D3ZHL6", "gene_name": "Map4k5", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3ZHL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZHL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D3ZHL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZHL6" } ] } ] }, { "uniprot_ac": "D3ZHP7", "gene_name": "Ulk3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3ZHP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZHP7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D3ZHP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZHP7" } ] } ] }, { "uniprot_ac": "D3ZJ84", "gene_name": "Tssk5", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3ZJ84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZJ84" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D3ZJ84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZJ84" } ] } ] }, { "uniprot_ac": "D3ZL21", "gene_name": "Tp53rka", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3ZL21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZL21" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D3ZL21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZL21" } ] } ] }, { "uniprot_ac": "D3ZMG0", "gene_name": "Ulk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3ZMG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZMG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D3ZMG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZMG0" } ] } ] }, { "uniprot_ac": "D3ZML2", "gene_name": "Brsk2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3ZML2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZML2" } ] }, { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "D3ZML2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZML2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D3ZML2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZML2" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "D3ZML2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZML2" } ] } ] }, { "uniprot_ac": "D3ZQN8", "gene_name": "Nuak1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3ZQN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQN8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D3ZQN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQN8" } ] } ] }, { "uniprot_ac": "D3ZRJ7", "gene_name": "Lrrk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3ZRJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZRJ7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D3ZRJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZRJ7" } ] } ] }, { "uniprot_ac": "D3ZSB7", "gene_name": "Rps6ka4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3ZSB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSB7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D3ZSB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSB7" } ] } ] }, { "uniprot_ac": "D3ZSY9", "gene_name": "Nek5", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3ZSY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D3ZSY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSY9" } ] } ] }, { "uniprot_ac": "D3ZSZ3", "gene_name": "Nlk", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3ZSZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSZ3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "D3ZSZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSZ3" } ] } ] }, { "uniprot_ac": "D3ZTD1", "gene_name": "Map3k14", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3ZTD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZTD1" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "D3ZTD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZTD1" } ] } ] }, { "uniprot_ac": "D3ZXB1", "gene_name": "Map4k2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3ZXB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZXB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D3ZXB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZXB1" } ] } ] }, { "uniprot_ac": "D3ZY07", "gene_name": "Plk5", "activity": [ { "ec_number": "2.7.11.21", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3ZY07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZY07" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "D3ZY07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZY07" } ] } ] }, { "uniprot_ac": "D3ZZK7", "gene_name": "Myo3a", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D3ZZK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZZK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D3ZZK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZZK7" } ] } ] }, { "uniprot_ac": "D4A229", "gene_name": "Prkd3", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D4A229", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A229" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "D4A229", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A229" } ] } ] }, { "uniprot_ac": "D4A280", "gene_name": "Pak5", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D4A280", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A280" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D4A280", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A280" } ] } ] }, { "uniprot_ac": "D4A355", "gene_name": "Mastl", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D4A355", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A355" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D4A355", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A355" } ] } ] }, { "uniprot_ac": "D4A3D9", "gene_name": "Stk32c", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D4A3D9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A3D9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D4A3D9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A3D9" } ] } ] }, { "uniprot_ac": "D4A3H8", "gene_name": "Nek11", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D4A3H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A3H8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D4A3H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A3H8" } ] } ] }, { "uniprot_ac": "D4A454", "gene_name": "Map3k21", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D4A454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A454" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "D4A454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A454" } ] } ] }, { "uniprot_ac": "D4A6T6", "gene_name": "Melk", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D4A6T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A6T6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D4A6T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A6T6" } ] } ] }, { "uniprot_ac": "D4A6T9", "gene_name": "Mark4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D4A6T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A6T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D4A6T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A6T9" } ] } ] }, { "uniprot_ac": "D4A7V9", "gene_name": "Eif2ak4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D4A7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A7V9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D4A7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A7V9" } ] } ] }, { "uniprot_ac": "D4A949", "gene_name": "Smokl1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D4A949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A949" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D4A949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A949" } ] } ] }, { "uniprot_ac": "D4A9H8", "gene_name": "Nim1k", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D4A9H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A9H8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D4A9H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A9H8" } ] } ] }, { "uniprot_ac": "D4ACL8", "gene_name": "Atm", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D4ACL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ACL8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D4ACL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ACL8" } ] } ] }, { "uniprot_ac": "D4AD76", "gene_name": "Aurkc", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D4AD76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AD76" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D4AD76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AD76" } ] } ] }, { "uniprot_ac": "D4AE24", "gene_name": "Rps6kb2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D4AE24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AE24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D4AE24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AE24" } ] } ] }, { "uniprot_ac": "D4AE59", "gene_name": "Stk11", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D4AE59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AE59" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D4AE59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AE59" } ] } ] }, { "uniprot_ac": "E9PSK5", "gene_name": "Sik2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "E9PSK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PSK5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E9PSK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PSK5" } ] } ] }, { "uniprot_ac": "E9PSL7", "gene_name": "Cit", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "E9PSL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PSL7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E9PSL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PSL7" } ] } ] }, { "uniprot_ac": "E9PSM2", "gene_name": "LOC301165", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "E9PSM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PSM2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E9PSM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PSM2" } ] } ] }, { "uniprot_ac": "E9PTG8", "gene_name": "Stk10", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "E9PTG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PTG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E9PTG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PTG8" } ] } ] }, { "uniprot_ac": "E9Q3S4", "gene_name": "Map3k19", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "E9Q3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E9Q3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q3S4" } ] } ] }, { "uniprot_ac": "F1LNJ1", "gene_name": "Lrrk2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "F1LNJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LNJ1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1LNJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LNJ1" } ] } ] }, { "uniprot_ac": "F1LNN8", "gene_name": "Dapk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "F1LNN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LNN8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1LNN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LNN8" } ] } ] }, { "uniprot_ac": "F1LP90", "gene_name": "Mink1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "F1LP90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LP90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1LP90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LP90" } ] } ] }, { "uniprot_ac": "F1LRA7", "gene_name": "Map3k9", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "F1LRA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LRA7" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1LRA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LRA7" } ] } ] }, { "uniprot_ac": "F1LTP9", "gene_name": "LOC120093110", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "F1LTP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LTP9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1LTP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LTP9" } ] } ] }, { "uniprot_ac": "F1LUY7", "gene_name": "Map3k15", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "F1LUY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LUY7" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1LUY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LUY7" } ] } ] }, { "uniprot_ac": "F1LWF2", "gene_name": "Dclk3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "F1LWF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LWF2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1LWF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LWF2" } ] } ] }, { "uniprot_ac": "F1LWJ6", "gene_name": "Myo3b", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "F1LWJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LWJ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1LWJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LWJ6" } ] } ] }, { "uniprot_ac": "F1LXF1", "gene_name": "Bcr", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "F1LXF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LXF1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1LXF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LXF1" } ] } ] }, { "uniprot_ac": "F1LYY7", "gene_name": "Dyrk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "F1LYY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LYY7" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "F1LYY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LYY7" } ] } ] }, { "uniprot_ac": "F1M0Z1", "gene_name": "Trio", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "F1M0Z1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M0Z1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1M0Z1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M0Z1" } ] } ] }, { "uniprot_ac": "F1M419", "gene_name": "Pim2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "F1M419", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M419" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1M419", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M419" } ] } ] }, { "uniprot_ac": "F1M7G0", "gene_name": "Trpm6", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "F1M7G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M7G0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1M7G0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M7G0" } ] } ] }, { "uniprot_ac": "F1M7N7", "gene_name": "Rps6ka2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "F1M7N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M7N7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1M7N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M7N7" } ] } ] }, { "uniprot_ac": "F1M7Y5", "gene_name": "Prkci", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "F1M7Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M7Y5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1M7Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M7Y5" } ] } ] }, { "uniprot_ac": "F1M9D0", "gene_name": "Map3k2", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "F1M9D0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M9D0" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1M9D0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M9D0" } ] } ] }, { "uniprot_ac": "F7FMK8", "gene_name": "Map3k13", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "F7FMK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F7FMK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F7FMK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F7FMK8" } ] } ] }, { "uniprot_ac": "G3V783", "gene_name": "Ripk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] } ] }, { "uniprot_ac": "J3KMT3", "gene_name": "Gm6882", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "J3KMT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/J3KMT3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "J3KMT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/J3KMT3" } ] } ] }, { "uniprot_ac": "J3QK59", "gene_name": "Gm6176", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "J3QK59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/J3QK59" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "J3QK59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/J3QK59" } ] } ] }, { "uniprot_ac": "M0R777", "gene_name": "LOC102551633", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "M0R777", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R777" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "M0R777", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R777" } ] } ] }, { "uniprot_ac": "M0R7E7", "gene_name": "Map2k3", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "M0R7E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R7E7" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "M0R7E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R7E7" } ] } ] }, { "uniprot_ac": "M0RBT0", "gene_name": "Haspin", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "M0RBT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RBT0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "M0RBT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RBT0" } ] } ] }, { "uniprot_ac": "M0RD40", "gene_name": "Sik3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "M0RD40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RD40" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "M0RD40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RD40" } ] } ] }, { "uniprot_ac": "M0RD88", "gene_name": "Smok2a", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "M0RD88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RD88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "M0RD88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RD88" } ] } ] }, { "uniprot_ac": "M0RDM0", "gene_name": "LOC103689976", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "M0RDM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RDM0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "M0RDM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RDM0" } ] } ] }, { "uniprot_ac": "M9NGC6", "gene_name": "Srpk79D", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "M9NGC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M9NGC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "M9NGC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M9NGC6" } ] } ] }, { "uniprot_ac": "M9PGC5", "gene_name": "Wnk", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "M9PGC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M9PGC5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "M9PGC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M9PGC5" } ] } ] }, { "uniprot_ac": "M9PI41", "gene_name": "sti", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "M9PI41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M9PI41" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "M9PI41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M9PI41" } ] } ] }, { "uniprot_ac": "O00141", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O00141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00141" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O00141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00141" } ] } ] }, { "uniprot_ac": "O00311", "gene_name": "CDC7", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O00311", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00311" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O00311", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00311" } ] } ] }, { "uniprot_ac": "O00444", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O00444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00444" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "O00444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00444" } ] } ] }, { "uniprot_ac": "O00487", "gene_name": "PSMD14", "activity": [ { "ec_number": "3.4.19.-", "activity": "", "evidence": [ { "id": "O00487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00487" } ] } ] }, { "uniprot_ac": "O00506", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O00506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00506" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O00506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00506" } ] } ] }, { "uniprot_ac": "O00762", "gene_name": "UBE2C", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O00762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00762" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "O00762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00762" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "O00762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00762" } ] } ] }, { "uniprot_ac": "O08605", "gene_name": "Mknk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O08605", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08605" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O08605", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08605" } ] } ] }, { "uniprot_ac": "O08648", "gene_name": "Map3k4", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O08648", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08648" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "O08648", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08648" } ] } ] }, { "uniprot_ac": "O08678", "gene_name": "Mark1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O08678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08678" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O08678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08678" } ] }, { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "O08678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08678" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "O08678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08678" } ] } ] }, { "uniprot_ac": "O08679", "gene_name": "Mark2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O08679", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08679" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O08679", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08679" } ] }, { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "O08679", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08679" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "O08679", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08679" } ] } ] }, { "uniprot_ac": "O08815", "gene_name": "Slk", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O08815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08815" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O08815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08815" } ] } ] }, { "uniprot_ac": "O08874", "gene_name": "Pkn2", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O08874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08874" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "O08874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08874" } ] } ] }, { "uniprot_ac": "O08875", "gene_name": "Dclk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O08875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08875" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O08875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08875" } ] } ] }, { "uniprot_ac": "O08901", "gene_name": "Bub1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O08901", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08901" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O08901", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08901" } ] } ] }, { "uniprot_ac": "O08911", "gene_name": "Mapk12", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O08911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08911" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "O08911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08911" } ] } ] }, { "uniprot_ac": "O09110", "gene_name": "Map2k3", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O09110", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09110" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "O09110", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09110" } ] } ] }, { "uniprot_ac": "O14578", "gene_name": "CIT", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O14578", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14578" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O14578", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14578" } ] } ] }, { "uniprot_ac": "O14730", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O14730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14730" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O14730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14730" } ] } ] }, { "uniprot_ac": "O14733", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O14733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14733" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "O14733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14733" } ] } ] }, { "uniprot_ac": "O14757", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O14757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14757" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O14757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14757" } ] } ] }, { "uniprot_ac": "O14874", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "O14874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14874" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O14874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14874" } ] }, { "ec_number": "2.7.11.4", "activity": "ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] = ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase].", "evidence": [ { "id": "O14874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14874" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O14874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14874" } ] } ] }, { "uniprot_ac": "O14920", "gene_name": "IKBKB", "activity": [ { "ec_number": "2.7.11.10", "activity": "ATP + L-seryl-[I-kappa-B protein] = ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein].", "evidence": [ { "id": "O14920", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14920" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "O14920", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14920" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O14920", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14920" } ] } ] }, { "uniprot_ac": "O14936", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O14936", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14936" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O14936", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14936" } ] } ] }, { "uniprot_ac": "O14965", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O14965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14965" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O14965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14965" } ] } ] }, { "uniprot_ac": "O14976", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O14976", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14976" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O14976", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14976" } ] } ] }, { "uniprot_ac": "O15021", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O15021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15021" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O15021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15021" } ] } ] }, { "uniprot_ac": "O15075", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O15075", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15075" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O15075", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15075" } ] } ] }, { "uniprot_ac": "O15264", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O15264", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15264" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "O15264", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15264" } ] } ] }, { "uniprot_ac": "O15530", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O15530", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15530" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O15530", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15530" } ] } ] }, { "uniprot_ac": "O35099", "gene_name": "Map3k5", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O35099", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35099" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "O35099", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35099" } ] } ] }, { "uniprot_ac": "O35280", "gene_name": "Chek1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O35280", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35280" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O35280", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35280" } ] } ] }, { "uniprot_ac": "O35491", "gene_name": "Clk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O35491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35491" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O35491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35491" } ] } ] }, { "uniprot_ac": "O35492", "gene_name": "Clk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O35492", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35492" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O35492", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35492" } ] } ] }, { "uniprot_ac": "O35493", "gene_name": "Clk4", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O35493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35493" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O35493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35493" } ] } ] }, { "uniprot_ac": "O35495", "gene_name": "Cdk14", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O35495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35495" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "O35495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35495" } ] } ] }, { "uniprot_ac": "O35831", "gene_name": "Cdk17", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O35831", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35831" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "O35831", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35831" } ] } ] }, { "uniprot_ac": "O35832", "gene_name": "Cdk18", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O35832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35832" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "O35832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35832" } ] } ] }, { "uniprot_ac": "O35942", "gene_name": "Nek2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O35942", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35942" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O35942", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35942" } ] } ] }, { "uniprot_ac": "O43283", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O43283", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43283" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "O43283", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43283" } ] } ] }, { "uniprot_ac": "O43293", "gene_name": "DAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O43293", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43293" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O43293", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43293" } ] } ] }, { "uniprot_ac": "O43318", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O43318", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43318" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "O43318", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43318" } ] } ] }, { "uniprot_ac": "O43353", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43353" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43353" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43353" } ] } ] }, { "uniprot_ac": "O43683", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O43683", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43683" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O43683", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43683" } ] } ] }, { "uniprot_ac": "O43781", "gene_name": "DYRK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O43781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43781" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O43781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43781" } ] } ] }, { "uniprot_ac": "O43930", "gene_name": "PRKY", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O43930", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43930" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O43930", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43930" } ] } ] }, { "uniprot_ac": "O54748", "gene_name": "Stk3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O54748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54748" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O54748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54748" } ] } ] }, { "uniprot_ac": "O54781", "gene_name": "Srpk2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O54781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54781" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O54781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54781" } ] } ] }, { "uniprot_ac": "O54784", "gene_name": "Dapk3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O54784", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54784" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O54784", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54784" } ] } ] }, { "uniprot_ac": "O54785", "gene_name": "Limk2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O54785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54785" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O54785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54785" } ] } ] }, { "uniprot_ac": "O54833", "gene_name": "Csnk2a2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O54833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54833" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O54833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54833" } ] } ] }, { "uniprot_ac": "O54863", "gene_name": "Tssk2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O54863", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54863" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O54863", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54863" } ] } ] }, { "uniprot_ac": "O54874", "gene_name": "Cdc42bpa", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O54874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54874" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O54874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54874" } ] } ] }, { "uniprot_ac": "O54949", "gene_name": "Nlk", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O54949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54949" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "O54949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54949" } ] } ] }, { "uniprot_ac": "O54967", "gene_name": "Tnk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O54967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54967" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "O54967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54967" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O54967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54967" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O54967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54967" } ] } ] }, { "uniprot_ac": "O54988", "gene_name": "Slk", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O54988", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54988" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O54988", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54988" } ] } ] }, { "uniprot_ac": "O54992", "gene_name": "Mapkapk5", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O54992", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54992" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O54992", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54992" } ] } ] }, { "uniprot_ac": "O55028", "gene_name": "Bckdk", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "O55028", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55028" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O55028", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55028" } ] }, { "ec_number": "2.7.11.4", "activity": "ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] = ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase].", "evidence": [ { "id": "O55028", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55028" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O55028", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55028" } ] } ] }, { "uniprot_ac": "O55047", "gene_name": "Tlk2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O55047", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55047" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O55047", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55047" } ] } ] }, { "uniprot_ac": "O55098", "gene_name": "Stk10", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O55098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55098" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O55098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55098" } ] } ] }, { "uniprot_ac": "O55099", "gene_name": "Aurkb", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O55099", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55099" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O55099", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55099" } ] } ] }, { "uniprot_ac": "O55173", "gene_name": "Pdpk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O55173", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55173" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O55173", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55173" } ] } ] }, { "uniprot_ac": "O55222", "gene_name": "Ilk", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O55222", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55222" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O55222", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55222" } ] } ] }, { "uniprot_ac": "O60229", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O60229", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60229" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O60229", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60229" } ] } ] }, { "uniprot_ac": "O60285", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O60285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60285" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O60285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60285" } ] } ] }, { "uniprot_ac": "O60307", "gene_name": "MAST3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O60307", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60307" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O60307", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60307" } ] } ] }, { "uniprot_ac": "O60566", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O60566", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60566" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O60566", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60566" } ] } ] }, { "uniprot_ac": "O61122", "gene_name": "svkA", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O61122", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61122" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O61122", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61122" } ] } ] }, { "uniprot_ac": "O61125", "gene_name": "krsA", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O61125", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61125" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O61125", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61125" } ] } ] }, { "uniprot_ac": "O61267", "gene_name": "lok", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O61267", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61267" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O61267", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61267" } ] }, { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "O61267", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61267" } ] } ] }, { "uniprot_ac": "O61443", "gene_name": "p38b", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O61443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61443" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "O61443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61443" } ] } ] }, { "uniprot_ac": "O61444", "gene_name": "Mkk4", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O61444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61444" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "O61444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61444" } ] } ] }, { "uniprot_ac": "O61661", "gene_name": "grp", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O61661", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61661" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O61661", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61661" } ] } ] }, { "uniprot_ac": "O62602", "gene_name": "lic", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O62602", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O62602" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "O62602", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O62602" } ] } ] }, { "uniprot_ac": "O62618", "gene_name": "p38a", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O62618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O62618" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "O62618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O62618" } ] } ] }, { "uniprot_ac": "O70126", "gene_name": "Aurkb", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O70126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70126" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O70126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70126" } ] } ] }, { "uniprot_ac": "O70146", "gene_name": "Tesk1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O70146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70146" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O70146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70146" } ] } ] }, { "uniprot_ac": "O70150", "gene_name": "Pnck", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O70150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70150" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "O70150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70150" } ] } ] }, { "uniprot_ac": "O70405", "gene_name": "Ulk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O70405", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70405" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O70405", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70405" } ] } ] }, { "uniprot_ac": "O70444", "gene_name": "Pim3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O70444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70444" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O70444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70444" } ] } ] }, { "uniprot_ac": "O70551", "gene_name": "Srpk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O70551", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70551" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O70551", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70551" } ] } ] }, { "uniprot_ac": "O70589", "gene_name": "Cask", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O70589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70589" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O70589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70589" } ] } ] }, { "uniprot_ac": "O75116", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O75116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75116" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O75116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75116" } ] } ] }, { "uniprot_ac": "O75385", "gene_name": "ULK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O75385", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75385" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O75385", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75385" } ] } ] }, { "uniprot_ac": "O75460", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O75460", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75460" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O75460", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75460" } ] }, { "ec_number": "3.1.26.-", "activity": "", "evidence": [ { "id": "O75460", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75460" } ] } ] }, { "uniprot_ac": "O75582", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O75582", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75582" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O75582", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75582" } ] } ] }, { "uniprot_ac": "O75676", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O75676", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75676" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O75676", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75676" } ] } ] }, { "uniprot_ac": "O75716", "gene_name": "STK16", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O75716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75716" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O75716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75716" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O75716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75716" } ] } ] }, { "uniprot_ac": "O75914", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O75914", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75914" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O75914", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75914" } ] } ] }, { "uniprot_ac": "O75962", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O75962", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75962" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O75962", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75962" } ] } ] }, { "uniprot_ac": "O76039", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O76039", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76039" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "O76039", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76039" } ] } ] }, { "uniprot_ac": "O76324", "gene_name": "dco", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O76324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76324" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O76324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76324" } ] } ] }, { "uniprot_ac": "O88351", "gene_name": "Ikbkb", "activity": [ { "ec_number": "2.7.11.10", "activity": "ATP + L-seryl-[I-kappa-B protein] = ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein].", "evidence": [ { "id": "O88351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88351" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "O88351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88351" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O88351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88351" } ] } ] }, { "uniprot_ac": "O88445", "gene_name": "Aurkc", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O88445", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88445" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O88445", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88445" } ] } ] }, { "uniprot_ac": "O88506", "gene_name": "Stk39", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O88506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88506" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O88506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88506" } ] } ] }, { "uniprot_ac": "O88643", "gene_name": "Pak1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O88643", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88643" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O88643", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88643" } ] } ] }, { "uniprot_ac": "O88664", "gene_name": "Taok1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O88664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88664" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O88664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88664" } ] } ] }, { "uniprot_ac": "O88697", "gene_name": "Stk16", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O88697", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88697" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O88697", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88697" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O88697", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88697" } ] } ] }, { "uniprot_ac": "O88764", "gene_name": "Dapk3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O88764", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88764" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O88764", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88764" } ] } ] }, { "uniprot_ac": "O88831", "gene_name": "Camkk2", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O88831", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88831" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "O88831", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88831" } ] } ] }, { "uniprot_ac": "O88850", "gene_name": "Hipk3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O88850", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88850" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O88850", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88850" } ] } ] }, { "uniprot_ac": "O88866", "gene_name": "Hunk", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O88866", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88866" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O88866", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88866" } ] } ] }, { "uniprot_ac": "O88904", "gene_name": "Hipk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O88904", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88904" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O88904", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88904" } ] } ] }, { "uniprot_ac": "O94768", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O94768", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94768" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O94768", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94768" } ] } ] }, { "uniprot_ac": "O94804", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O94804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94804" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O94804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94804" } ] } ] }, { "uniprot_ac": "O94806", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O94806", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94806" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "O94806", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94806" } ] } ] }, { "uniprot_ac": "O94921", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O94921", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94921" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "O94921", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94921" } ] } ] }, { "uniprot_ac": "O95382", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O95382", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95382" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "O95382", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95382" } ] } ] }, { "uniprot_ac": "O95747", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O95747", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95747" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O95747", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95747" } ] } ] }, { "uniprot_ac": "O95819", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O95819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95819" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O95819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95819" } ] } ] }, { "uniprot_ac": "O95835", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O95835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95835" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O95835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95835" } ] } ] }, { "uniprot_ac": "O96013", "gene_name": "PAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O96013", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O96013" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O96013", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O96013" } ] } ] }, { "uniprot_ac": "O96017", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O96017", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O96017" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O96017", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O96017" } ] } ] }, { "uniprot_ac": "O97143", "gene_name": "SAK", "activity": [ { "ec_number": "2.7.11.21", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O97143", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O97143" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "O97143", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O97143" } ] } ] }, { "uniprot_ac": "P00536", "gene_name": "Mos", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P00536", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00536" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P00536", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00536" } ] } ] }, { "uniprot_ac": "P00539", "gene_name": "Mos", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P00539", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00539" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P00539", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00539" } ] } ] }, { "uniprot_ac": "P00540", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P00540", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00540" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P00540", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00540" } ] } ] }, { "uniprot_ac": "P00546", "gene_name": "CDC28", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P00546", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00546" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P00546", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00546" } ] } ] }, { "uniprot_ac": "P04049", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P04049", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04049" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P04049", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04049" } ] } ] }, { "uniprot_ac": "P04627", "gene_name": "Araf", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P04627", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04627" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P04627", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04627" } ] } ] }, { "uniprot_ac": "P05129", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P05129", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05129" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05129", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05129" } ] } ] }, { "uniprot_ac": "P05130", "gene_name": "Pkc53E", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P05130", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05130" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05130", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05130" } ] } ] }, { "uniprot_ac": "P05132", "gene_name": "Prkaca", "activity": [ { "ec_number": "2.7.11.11", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P05132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05132" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05132" } ] } ] }, { "uniprot_ac": "P05696", "gene_name": "Prkca", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P05696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05696" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05696" } ] } ] }, { "uniprot_ac": "P05771", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P05771", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05771" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05771", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05771" } ] } ] }, { "uniprot_ac": "P05986", "gene_name": "TPK3", "activity": [ { "ec_number": "2.7.11.11", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P05986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05986" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05986" } ] } ] }, { "uniprot_ac": "P06242", "gene_name": "KIN28", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "P06242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06242" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P06242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06242" } ] } ] }, { "uniprot_ac": "P06243", "gene_name": "CDC7", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P06243", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06243" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P06243", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06243" } ] } ] }, { "uniprot_ac": "P06244", "gene_name": "TPK1", "activity": [ { "ec_number": "2.7.11.11", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P06244", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06244" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P06244", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06244" } ] } ] }, { "uniprot_ac": "P06245", "gene_name": "TPK2", "activity": [ { "ec_number": "2.7.11.11", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P06245", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06245" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P06245", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06245" } ] } ] }, { "uniprot_ac": "P06493", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P06493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06493" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "P06493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06493" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P06493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06493" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P06493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06493" } ] } ] }, { "uniprot_ac": "P06782", "gene_name": "SNF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P06782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06782" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P06782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06782" } ] } ] }, { "uniprot_ac": "P06784", "gene_name": "STE7", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P06784", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06784" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P06784", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06784" } ] } ] }, { "uniprot_ac": "P06803", "gene_name": "Pim1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P06803", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06803" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P06803", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06803" } ] } ] }, { "uniprot_ac": "P07900", "gene_name": "HSP90AA1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P07900", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07900" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P07900", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07900" } ] } ] }, { "uniprot_ac": "P07934", "gene_name": "Phkg1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P07934", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07934" } ] }, { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "P07934", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07934" } ] }, { "ec_number": "2.7.11.19", "activity": "2 ATP + phosphorylase b = 2 ADP + phosphorylase a.", "evidence": [ { "id": "P07934", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07934" } ] }, { "ec_number": "2.7.11.19", "activity": "", "evidence": [ { "id": "P07934", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07934" } ] } ] }, { "uniprot_ac": "P08018", "gene_name": "PBS2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P08018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08018" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P08018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08018" } ] } ] }, { "uniprot_ac": "P08181", "gene_name": "CkIIalpha", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P08181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08181" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P08181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08181" } ] } ] }, { "uniprot_ac": "P08413", "gene_name": "Camk2b", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P08413", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08413" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "P08413", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08413" } ] } ] }, { "uniprot_ac": "P08414", "gene_name": "Camk4", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P08414", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08414" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "P08414", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08414" } ] } ] }, { "uniprot_ac": "P08458", "gene_name": "SPS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P08458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08458" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P08458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08458" } ] } ] }, { "uniprot_ac": "P09215", "gene_name": "Prkcd", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P09215", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09215" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P09215", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09215" } ] } ] }, { "uniprot_ac": "P09216", "gene_name": "Prkce", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P09216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09216" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P09216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09216" } ] } ] }, { "uniprot_ac": "P09217", "gene_name": "Prkcz", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P09217", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09217" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P09217", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09217" } ] } ] }, { "uniprot_ac": "P0C0R5", "gene_name": "Pik3r4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P0C0R5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C0R5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P0C0R5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C0R5" } ] } ] }, { "uniprot_ac": "P0C1X8", "gene_name": "Aak1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P0C1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1X8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P0C1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1X8" } ] } ] }, { "uniprot_ac": "P0C263", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P0C263", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C263" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P0C263", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C263" } ] } ] }, { "uniprot_ac": "P0C264", "gene_name": "SBK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P0C264", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C264" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P0C264", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C264" } ] } ] }, { "uniprot_ac": "P0C5K0", "gene_name": "Sbk3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P0C5K0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C5K0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P0C5K0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C5K0" } ] } ] }, { "uniprot_ac": "P0C5K1", "gene_name": "Sbk2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P0C5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C5K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P0C5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C5K1" } ] } ] }, { "uniprot_ac": "P0C605", "gene_name": "Prkg1", "activity": [ { "ec_number": "2.7.11.12", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P0C605", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C605" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P0C605", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C605" } ] } ] }, { "uniprot_ac": "P0C865", "gene_name": "Mapk7", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P0C865", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C865" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P0C865", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C865" } ] } ] }, { "uniprot_ac": "P0C8E4", "gene_name": "Map3k7", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P0C8E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C8E4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "P0C8E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C8E4" } ] } ] }, { "uniprot_ac": "P0CD62", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P0CD62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CD62" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P0CD62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CD62" } ] } ] }, { "uniprot_ac": "P0DPH7", "gene_name": "TUBA3C", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P0DPH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DPH7" } ] } ] }, { "uniprot_ac": "P0DPH8", "gene_name": "TUBA3D", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P0DPH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DPH8" } ] } ] }, { "uniprot_ac": "P10398", "gene_name": "ARAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P10398", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10398" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P10398", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10398" } ] } ] }, { "uniprot_ac": "P10676", "gene_name": "ninaC", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P10676", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10676" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P10676", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10676" } ] } ] }, { "uniprot_ac": "P11274", "gene_name": "BCR", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P11274", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11274" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P11274", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11274" } ] } ] }, { "uniprot_ac": "P11275", "gene_name": "Camk2a", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P11275", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11275" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "P11275", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11275" } ] } ] }, { "uniprot_ac": "P11309", "gene_name": "PIM1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P11309", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11309" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P11309", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11309" } ] } ] }, { "uniprot_ac": "P11345", "gene_name": "Raf1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P11345", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11345" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P11345", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11345" } ] } ] }, { "uniprot_ac": "P11346", "gene_name": "Raf", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P11346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11346" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P11346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11346" } ] } ] }, { "uniprot_ac": "P11440", "gene_name": "Cdk1", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P11440", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11440" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "P11440", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11440" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P11440", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11440" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P11440", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11440" } ] } ] }, { "uniprot_ac": "P11730", "gene_name": "Camk2g", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P11730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11730" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "P11730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11730" } ] } ] }, { "uniprot_ac": "P11792", "gene_name": "SCH9", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P11792", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11792" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P11792", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11792" } ] } ] }, { "uniprot_ac": "P11798", "gene_name": "Camk2a", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P11798", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11798" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "P11798", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11798" } ] } ] }, { "uniprot_ac": "P11801", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P11801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11801" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P11801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11801" } ] } ] }, { "uniprot_ac": "P11802", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P11802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11802" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P11802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11802" } ] } ] }, { "uniprot_ac": "P11980", "gene_name": "Pkm", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] } ] }, { "uniprot_ac": "P12370", "gene_name": "Pka-C1", "activity": [ { "ec_number": "2.7.11.11", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P12370", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12370" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P12370", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12370" } ] } ] }, { "uniprot_ac": "P12688", "gene_name": "YPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P12688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12688" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P12688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12688" } ] } ] }, { "uniprot_ac": "P13185", "gene_name": "KIN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P13185", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13185" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P13185", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13185" } ] } ] }, { "uniprot_ac": "P13186", "gene_name": "KIN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P13186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13186" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P13186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13186" } ] } ] }, { "uniprot_ac": "P13234", "gene_name": "Camk4", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P13234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13234" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "P13234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13234" } ] } ] }, { "uniprot_ac": "P13286", "gene_name": "Phkg1", "activity": [ { "ec_number": "2.7.11.19", "activity": "2 ATP + phosphorylase b = 2 ADP + phosphorylase a.", "evidence": [ { "id": "P13286", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13286" } ] }, { "ec_number": "2.7.11.19", "activity": "", "evidence": [ { "id": "P13286", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13286" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P13286", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13286" } ] }, { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "P13286", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13286" } ] } ] }, { "uniprot_ac": "P13677", "gene_name": "inaC", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P13677", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13677" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P13677", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13677" } ] } ] }, { "uniprot_ac": "P13678", "gene_name": "Pkc98E", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P13678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13678" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P13678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13678" } ] } ] }, { "uniprot_ac": "P14056", "gene_name": "Araf", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P14056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14056" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P14056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14056" } ] } ] }, { "uniprot_ac": "P14618", "gene_name": "PKM", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] } ] }, { "uniprot_ac": "P14680", "gene_name": "YAK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14680" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14680" } ] } ] }, { "uniprot_ac": "P14681", "gene_name": "KSS1", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P14681", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14681" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P14681", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14681" } ] } ] }, { "uniprot_ac": "P15056", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P15056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15056" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P15056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15056" } ] } ] }, { "uniprot_ac": "P15442", "gene_name": "GCN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P15442", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15442" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P15442", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15442" } ] } ] }, { "uniprot_ac": "P15790", "gene_name": "CKA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P15790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15790" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P15790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15790" } ] } ] }, { "uniprot_ac": "P15791", "gene_name": "Camk2d", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P15791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15791" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "P15791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15791" } ] } ] }, { "uniprot_ac": "P16054", "gene_name": "Prkce", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P16054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16054" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P16054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16054" } ] } ] }, { "uniprot_ac": "P16892", "gene_name": "FUS3", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P16892", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16892" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P16892", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16892" } ] } ] }, { "uniprot_ac": "P16911", "gene_name": "Pka-C2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P16911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16911" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P16911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16911" } ] }, { "ec_number": "2.7.11.11", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P16911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16911" } ] }, { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "P16911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16911" } ] } ] }, { "uniprot_ac": "P16912", "gene_name": "Pka-C3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P16912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16912" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P16912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16912" } ] } ] }, { "uniprot_ac": "P17157", "gene_name": "PHO85", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P17157", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17157" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P17157", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17157" } ] } ] }, { "uniprot_ac": "P17252", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P17252", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17252" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P17252", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17252" } ] } ] }, { "uniprot_ac": "P17612", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P17612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17612" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P17612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17612" } ] } ] }, { "uniprot_ac": "P18265", "gene_name": "Gsk3a", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P18265", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18265" } ] }, { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "P18265", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18265" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "P18265", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18265" } ] } ] }, { "uniprot_ac": "P18266", "gene_name": "Gsk3b", "activity": [ { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "P18266", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18266" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "P18266", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18266" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P18266", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18266" } ] } ] }, { "uniprot_ac": "P18431", "gene_name": "sgg", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P18431", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18431" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P18431", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18431" } ] } ] }, { "uniprot_ac": "P18653", "gene_name": "Rps6ka1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P18653", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18653" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P18653", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18653" } ] } ] }, { "uniprot_ac": "P18654", "gene_name": "Rps6ka3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P18654", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18654" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P18654", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18654" } ] } ] }, { "uniprot_ac": "P18961", "gene_name": "YPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P18961", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18961" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P18961", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18961" } ] } ] }, { "uniprot_ac": "P19139", "gene_name": "Csnk2a1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P19139", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19139" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P19139", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19139" } ] } ] }, { "uniprot_ac": "P19454", "gene_name": "CKA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P19454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19454" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P19454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19454" } ] } ] }, { "uniprot_ac": "P19525", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P19525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19525" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P19525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19525" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P19525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19525" } ] } ] }, { "uniprot_ac": "P19784", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P19784", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19784" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P19784", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19784" } ] } ] }, { "uniprot_ac": "P20444", "gene_name": "Prkca", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P20444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20444" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P20444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20444" } ] } ] }, { "uniprot_ac": "P20793", "gene_name": "Mak", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P20793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20793" } ] } ] }, { "uniprot_ac": "P20794", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P20794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20794" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20794" } ] } ] }, { "uniprot_ac": "P21127", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P21127", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21127" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P21127", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21127" } ] } ] }, { "uniprot_ac": "P21675", "gene_name": "TAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P21675", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21675" } ] }, { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "P21675", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21675" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P21675", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21675" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "P21675", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21675" } ] } ] }, { "uniprot_ac": "P21708", "gene_name": "Mapk3", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P21708", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21708" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P21708", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21708" } ] } ] }, { "uniprot_ac": "P21965", "gene_name": "MCK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P21965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21965" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P21965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21965" } ] } ] }, { "uniprot_ac": "P22204", "gene_name": "DBF2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P22204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22204" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P22204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22204" } ] } ] }, { "uniprot_ac": "P22209", "gene_name": "KIN3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P22209", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22209" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P22209", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22209" } ] } ] }, { "uniprot_ac": "P22211", "gene_name": "NPR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P22211", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22211" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P22211", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22211" } ] } ] }, { "uniprot_ac": "P22216", "gene_name": "RAD53", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P22216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22216" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P22216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22216" } ] } ] }, { "uniprot_ac": "P22219", "gene_name": "VPS15", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P22219", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22219" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P22219", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22219" } ] } ] }, { "uniprot_ac": "P22517", "gene_name": "CMK2", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P22517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22517" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "P22517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22517" } ] } ] }, { "uniprot_ac": "P22518", "gene_name": "Clk1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P22518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22518" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P22518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22518" } ] } ] }, { "uniprot_ac": "P22612", "gene_name": "PRKACG", "activity": [ { "ec_number": "2.7.11.11", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P22612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22612" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P22612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22612" } ] } ] }, { "uniprot_ac": "P22694", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P22694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22694" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P22694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22694" } ] } ] }, { "uniprot_ac": "P23291", "gene_name": "YCK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P23291", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23291" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P23291", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23291" } ] } ] }, { "uniprot_ac": "P23292", "gene_name": "YCK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P23292", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23292" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P23292", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23292" } ] } ] }, { "uniprot_ac": "P23293", "gene_name": "SGV1", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P23293", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23293" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "P23293", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23293" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P23293", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23293" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P23293", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23293" } ] } ] }, { "uniprot_ac": "P23298", "gene_name": "Prkch", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P23298", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23298" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P23298", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23298" } ] } ] }, { "uniprot_ac": "P23443", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P23443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P23443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23443" } ] } ] }, { "uniprot_ac": "P23561", "gene_name": "STE11", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P23561", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23561" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "P23561", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23561" } ] } ] }, { "uniprot_ac": "P23572", "gene_name": "Cdk1", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P23572", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23572" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "P23572", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23572" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P23572", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23572" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P23572", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23572" } ] } ] }, { "uniprot_ac": "P23573", "gene_name": "Cdk2", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P23573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23573" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "P23573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23573" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P23573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23573" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P23573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23573" } ] } ] }, { "uniprot_ac": "P23647", "gene_name": "fu", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P23647", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23647" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P23647", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23647" } ] } ] }, { "uniprot_ac": "P24583", "gene_name": "PKC1", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P24583", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24583" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P24583", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24583" } ] } ] }, { "uniprot_ac": "P24719", "gene_name": "MEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P24719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24719" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P24719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24719" } ] } ] }, { "uniprot_ac": "P24723", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P24723", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24723" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P24723", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24723" } ] } ] }, { "uniprot_ac": "P24788", "gene_name": "Cdk11b", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P24788", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24788" } ] } ] }, { "uniprot_ac": "P24941", "gene_name": "CDK2", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P24941", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24941" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P24941", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24941" } ] } ] }, { "uniprot_ac": "P25333", "gene_name": "SAT4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P25333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25333" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P25333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25333" } ] } ] }, { "uniprot_ac": "P25341", "gene_name": "KIN82", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P25341", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25341" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P25341", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25341" } ] } ] }, { "uniprot_ac": "P25389", "gene_name": "KCC4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P25389", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25389" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P25389", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25389" } ] } ] }, { "uniprot_ac": "P25390", "gene_name": "SSK22", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P25390", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25390" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P25390", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25390" } ] } ] }, { "uniprot_ac": "P26794", "gene_name": "Pim1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P26794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26794" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P26794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26794" } ] } ] }, { "uniprot_ac": "P27361", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P27361", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27361" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P27361", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27361" } ] } ] }, { "uniprot_ac": "P27448", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P27448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27448" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P27448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27448" } ] } ] }, { "uniprot_ac": "P27466", "gene_name": "CMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P27466", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27466" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "P27466", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27466" } ] } ] }, { "uniprot_ac": "P27636", "gene_name": "CDC15", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P27636", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27636" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P27636", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27636" } ] } ] }, { "uniprot_ac": "P27704", "gene_name": "Mapk6", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P27704", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27704" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P27704", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27704" } ] } ] }, { "uniprot_ac": "P27791", "gene_name": "Prkaca", "activity": [ { "ec_number": "2.7.11.11", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P27791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27791" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P27791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27791" } ] } ] }, { "uniprot_ac": "P28028", "gene_name": "Braf", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P28028", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28028" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P28028", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28028" } ] } ] }, { "uniprot_ac": "P28062", "gene_name": "PSMB8", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "P28062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28062" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "P28062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28062" } ] } ] }, { "uniprot_ac": "P28065", "gene_name": "PSMB9", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "P28065", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28065" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "P28065", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28065" } ] } ] }, { "uniprot_ac": "P28072", "gene_name": "PSMB6", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "P28072", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28072" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "P28072", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28072" } ] } ] }, { "uniprot_ac": "P28074", "gene_name": "PSMB5", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "P28074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28074" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "P28074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28074" } ] } ] }, { "uniprot_ac": "P28178", "gene_name": "pkgB", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P28178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28178" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P28178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28178" } ] } ] }, { "uniprot_ac": "P28482", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P28482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28482" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P28482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28482" } ] } ] }, { "uniprot_ac": "P28652", "gene_name": "Camk2b", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P28652", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28652" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "P28652", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28652" } ] } ] }, { "uniprot_ac": "P28708", "gene_name": "PRR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P28708", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28708" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P28708", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28708" } ] } ] }, { "uniprot_ac": "P28867", "gene_name": "Prkcd", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P28867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28867" } ] }, { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P28867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28867" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P28867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28867" } ] } ] }, { "uniprot_ac": "P29295", "gene_name": "HRR25", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P29295", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29295" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P29295", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29295" } ] } ] }, { "uniprot_ac": "P30285", "gene_name": "Cdk4", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P30285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30285" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P30285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30285" } ] } ] }, { "uniprot_ac": "P30291", "gene_name": "WEE1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P30291", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30291" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P30291", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30291" } ] } ] }, { "uniprot_ac": "P30304", "gene_name": "CDC25A", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P30304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30304" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P30304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30304" } ] } ] }, { "uniprot_ac": "P30305", "gene_name": "CDC25B", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P30305", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30305" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P30305", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30305" } ] } ] }, { "uniprot_ac": "P30307", "gene_name": "CDC25C", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P30307", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30307" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P30307", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30307" } ] } ] }, { "uniprot_ac": "P31152", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P31152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31152" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P31152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31152" } ] } ] }, { "uniprot_ac": "P31374", "gene_name": "PSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P31374", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31374" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P31374", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31374" } ] } ] }, { "uniprot_ac": "P31749", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P31749", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31749" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P31749", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31749" } ] } ] }, { "uniprot_ac": "P31750", "gene_name": "Akt1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P31750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31750" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P31750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31750" } ] } ] }, { "uniprot_ac": "P31751", "gene_name": "AKT2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P31751", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31751" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P31751", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31751" } ] } ] }, { "uniprot_ac": "P31938", "gene_name": "Map2k1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P31938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31938" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P31938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31938" } ] } ] }, { "uniprot_ac": "P32328", "gene_name": "DBF20", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32328", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32328" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32328", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32328" } ] } ] }, { "uniprot_ac": "P32350", "gene_name": "KNS1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32350" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P32350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32350" } ] } ] }, { "uniprot_ac": "P32361", "gene_name": "IRE1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32361", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32361" } ] }, { "ec_number": "3.1.26.-", "activity": "", "evidence": [ { "id": "P32361", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32361" } ] } ] }, { "uniprot_ac": "P32485", "gene_name": "HOG1", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32485", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32485" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P32485", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32485" } ] } ] }, { "uniprot_ac": "P32490", "gene_name": "MKK1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32490" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P32490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32490" } ] } ] }, { "uniprot_ac": "P32491", "gene_name": "MKK2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32491" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P32491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32491" } ] } ] }, { "uniprot_ac": "P32562", "gene_name": "CDC5", "activity": [ { "ec_number": "2.7.11.21", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32562" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "P32562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32562" } ] } ] }, { "uniprot_ac": "P32581", "gene_name": "IME2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32581" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32581" } ] } ] }, { "uniprot_ac": "P32600", "gene_name": "TOR2", "activity": [ { "ec_number": "2.7.1.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32600" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32600" } ] }, { "ec_number": "2.7.1.67", "activity": "", "evidence": [ { "id": "P32600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32600" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32600" } ] } ] }, { "uniprot_ac": "P32789", "gene_name": "ALK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32789", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32789" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32789", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32789" } ] } ] }, { "uniprot_ac": "P32801", "gene_name": "ELM1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32801" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32801" } ] } ] }, { "uniprot_ac": "P32944", "gene_name": "SWE1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32944", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32944" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32944", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32944" } ] } ] }, { "uniprot_ac": "P33076", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P33076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33076" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "P33076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33076" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P33076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33076" } ] } ] }, { "uniprot_ac": "P33981", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P33981", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33981" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P33981", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33981" } ] } ] }, { "uniprot_ac": "P34099", "gene_name": "pkaC", "activity": [ { "ec_number": "2.7.11.11", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P34099", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34099" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P34099", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34099" } ] } ] }, { "uniprot_ac": "P34100", "gene_name": "pkaD", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P34100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34100" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P34100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34100" } ] } ] }, { "uniprot_ac": "P34101", "gene_name": "fhkC", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P34101", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34101" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P34101", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34101" } ] } ] }, { "uniprot_ac": "P34102", "gene_name": "pkgC", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P34102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34102" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P34102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34102" } ] } ] }, { "uniprot_ac": "P34103", "gene_name": "pkgD", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P34103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34103" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P34103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34103" } ] } ] }, { "uniprot_ac": "P34112", "gene_name": "cdk1", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P34112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34112" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "P34112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34112" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P34112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34112" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P34112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34112" } ] } ] }, { "uniprot_ac": "P34117", "gene_name": "cdk5", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P34117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34117" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P34117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34117" } ] } ] }, { "uniprot_ac": "P34244", "gene_name": "HSL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P34244", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34244" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P34244", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34244" } ] } ] }, { "uniprot_ac": "P35169", "gene_name": "TOR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P35169", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35169" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35169", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35169" } ] } ] }, { "uniprot_ac": "P35426", "gene_name": "Cdk4", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P35426", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35426" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P35426", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35426" } ] } ] }, { "uniprot_ac": "P35465", "gene_name": "Pak1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P35465", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35465" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35465", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35465" } ] } ] }, { "uniprot_ac": "P35761", "gene_name": "Ttk", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P35761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35761" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P35761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35761" } ] } ] }, { "uniprot_ac": "P36002", "gene_name": "PTK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P36002", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36002" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P36002", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36002" } ] } ] }, { "uniprot_ac": "P36003", "gene_name": "NNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P36003", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36003" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P36003", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36003" } ] } ] }, { "uniprot_ac": "P36004", "gene_name": "KKQ8", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P36004", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36004" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P36004", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36004" } ] } ] }, { "uniprot_ac": "P36005", "gene_name": "KDX1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P36005", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36005" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P36005", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36005" } ] } ] }, { "uniprot_ac": "P36506", "gene_name": "Map2k2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P36506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36506" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P36506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36506" } ] } ] }, { "uniprot_ac": "P36507", "gene_name": "MAP2K2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P36507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36507" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P36507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36507" } ] } ] }, { "uniprot_ac": "P36873", "gene_name": "PPP1CC", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P36873", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36873" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P36873", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36873" } ] } ] }, { "uniprot_ac": "P38070", "gene_name": "YPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P38070", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38070" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P38070", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38070" } ] } ] }, { "uniprot_ac": "P38080", "gene_name": "AKL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P38080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38080" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P38080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38080" } ] } ] }, { "uniprot_ac": "P38110", "gene_name": "TEL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P38110", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38110" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P38110", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38110" } ] } ] }, { "uniprot_ac": "P38111", "gene_name": "MEC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P38111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38111" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P38111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38111" } ] } ] }, { "uniprot_ac": "P38147", "gene_name": "CHK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P38147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38147" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P38147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38147" } ] } ] }, { "uniprot_ac": "P38615", "gene_name": "RIM11", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P38615", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38615" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P38615", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38615" } ] } ] }, { "uniprot_ac": "P38622", "gene_name": "RCK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P38622", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38622" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P38622", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38622" } ] } ] }, { "uniprot_ac": "P38623", "gene_name": "RCK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P38623", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38623" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P38623", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38623" } ] } ] }, { "uniprot_ac": "P38691", "gene_name": "KSP1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P38691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38691" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P38691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38691" } ] } ] }, { "uniprot_ac": "P38692", "gene_name": "KIC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P38692", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38692" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P38692", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38692" } ] } ] }, { "uniprot_ac": "P38970", "gene_name": "HAL5", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P38970", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38970" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P38970", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38970" } ] } ] }, { "uniprot_ac": "P38990", "gene_name": "SAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P38990", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38990" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P38990", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38990" } ] } ] }, { "uniprot_ac": "P38991", "gene_name": "IPL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P38991", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38991" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P38991", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38991" } ] } ] }, { "uniprot_ac": "P39009", "gene_name": "DUN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P39009", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39009" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P39009", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39009" } ] } ] }, { "uniprot_ac": "P39073", "gene_name": "SSN3", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P39073", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39073" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "P39073", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39073" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P39073", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39073" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P39073", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39073" } ] } ] }, { "uniprot_ac": "P39951", "gene_name": "Cdk1", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P39951", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39951" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "P39951", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39951" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P39951", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39951" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P39951", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39951" } ] } ] }, { "uniprot_ac": "P39962", "gene_name": "YCK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P39962", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39962" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P39962", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39962" } ] } ] }, { "uniprot_ac": "P40160", "gene_name": "RIO2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P40160", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40160" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P40160", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40160" } ] } ] }, { "uniprot_ac": "P40306", "gene_name": "PSMB10", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "P40306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40306" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "P40306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40306" } ] } ] }, { "uniprot_ac": "P40417", "gene_name": "rl", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P40417", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40417" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P40417", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40417" } ] } ] }, { "uniprot_ac": "P40494", "gene_name": "PRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P40494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40494" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P40494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40494" } ] } ] }, { "uniprot_ac": "P41279", "gene_name": "MAP3K8", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P41279", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41279" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "P41279", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41279" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P41279", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41279" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P41279", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41279" } ] } ] }, { "uniprot_ac": "P41695", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P41695", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41695" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P41695", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41695" } ] } ] }, { "uniprot_ac": "P41743", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P41743", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41743" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P41743", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41743" } ] } ] }, { "uniprot_ac": "P41808", "gene_name": "SMK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P41808", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41808" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P41808", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41808" } ] } ] }, { "uniprot_ac": "P42336", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P42336", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42336" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P42336", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42336" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P42336", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42336" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P42336", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42336" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P42336", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42336" } ] } ] }, { "uniprot_ac": "P42337", "gene_name": "Pik3ca", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P42337", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42337" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P42337", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42337" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P42337", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42337" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P42337", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42337" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P42337", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42337" } ] } ] }, { "uniprot_ac": "P42338", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P42338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42338" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P42338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42338" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P42338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42338" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P42338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42338" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P42338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42338" } ] } ] }, { "uniprot_ac": "P42345", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P42345", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42345" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P42345", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42345" } ] } ] }, { "uniprot_ac": "P42346", "gene_name": "Mtor", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P42346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42346" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P42346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42346" } ] } ] }, { "uniprot_ac": "P42525", "gene_name": "erkA", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P42525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42525" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P42525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42525" } ] } ] }, { "uniprot_ac": "P43565", "gene_name": "RIM15", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P43565", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43565" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P43565", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43565" } ] } ] }, { "uniprot_ac": "P43568", "gene_name": "CAK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P43568", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43568" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P43568", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43568" } ] } ] }, { "uniprot_ac": "P43633", "gene_name": "ALK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P43633", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43633" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P43633", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43633" } ] } ] }, { "uniprot_ac": "P43637", "gene_name": "TOS3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P43637", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43637" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P43637", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43637" } ] } ] }, { "uniprot_ac": "P45983", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P45983", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45983" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P45983", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45983" } ] } ] }, { "uniprot_ac": "P45984", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P45984", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45984" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P45984", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45984" } ] } ] }, { "uniprot_ac": "P45985", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P45985", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45985" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P45985", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45985" } ] } ] }, { "uniprot_ac": "P46734", "gene_name": "MAP2K3", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P46734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46734" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P46734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46734" } ] } ] }, { "uniprot_ac": "P46892", "gene_name": "Cdk11b", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P46892", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46892" } ] } ] }, { "uniprot_ac": "P47042", "gene_name": "IKS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P47042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47042" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P47042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47042" } ] } ] }, { "uniprot_ac": "P47116", "gene_name": "PTK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P47116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47116" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P47116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47116" } ] } ] }, { "uniprot_ac": "P47196", "gene_name": "Akt1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P47196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47196" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P47196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47196" } ] } ] }, { "uniprot_ac": "P47197", "gene_name": "Akt2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P47197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47197" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P47197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47197" } ] } ] }, { "uniprot_ac": "P47809", "gene_name": "Map2k4", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P47809", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47809" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P47809", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47809" } ] } ] }, { "uniprot_ac": "P47811", "gene_name": "Mapk14", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P47811", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47811" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P47811", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47811" } ] } ] }, { "uniprot_ac": "P48562", "gene_name": "CLA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P48562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48562" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P48562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48562" } ] } ] }, { "uniprot_ac": "P48609", "gene_name": "Cdk5", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P48609", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48609" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48609", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48609" } ] } ] }, { "uniprot_ac": "P48729", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P48729", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48729" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P48729", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48729" } ] } ] }, { "uniprot_ac": "P48730", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P48730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48730" } ] }, { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "P48730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48730" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "P48730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48730" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P48730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48730" } ] } ] }, { "uniprot_ac": "P48736", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P48736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48736" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P48736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48736" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P48736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48736" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "P48736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48736" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P48736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48736" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P48736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48736" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "P48736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48736" } ] } ] }, { "uniprot_ac": "P49025", "gene_name": "Cit", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49025", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49025" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P49025", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49025" } ] } ] }, { "uniprot_ac": "P49071", "gene_name": "MAPk-Ak2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49071" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P49071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49071" } ] } ] }, { "uniprot_ac": "P49137", "gene_name": "MAPKAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49137" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P49137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49137" } ] } ] }, { "uniprot_ac": "P49138", "gene_name": "Mapkapk2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49138" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P49138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49138" } ] } ] }, { "uniprot_ac": "P49185", "gene_name": "Mapk8", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49185", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49185" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P49185", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49185" } ] } ] }, { "uniprot_ac": "P49186", "gene_name": "Mapk9", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49186" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P49186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49186" } ] } ] }, { "uniprot_ac": "P49187", "gene_name": "Mapk10", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49187", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49187" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P49187", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49187" } ] } ] }, { "uniprot_ac": "P49336", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49336", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49336" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "P49336", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49336" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P49336", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49336" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P49336", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49336" } ] } ] }, { "uniprot_ac": "P49615", "gene_name": "Cdk5", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49615", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49615" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P49615", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49615" } ] } ] }, { "uniprot_ac": "P49657", "gene_name": "mnb", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49657" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49657" } ] } ] }, { "uniprot_ac": "P49674", "gene_name": "CSNK1E", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49674" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P49674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49674" } ] } ] }, { "uniprot_ac": "P49759", "gene_name": "CLK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49759" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49759" } ] } ] }, { "uniprot_ac": "P49760", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49760" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49760" } ] } ] }, { "uniprot_ac": "P49761", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49761" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49761" } ] } ] }, { "uniprot_ac": "P49762", "gene_name": "Doa", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "P49762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49762" } ] }, { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49762" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49762" } ] } ] }, { "uniprot_ac": "P49792", "gene_name": "RANBP2", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "P49792", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49792" } ] }, { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P49792", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49792" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P49792", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49792" } ] } ] }, { "uniprot_ac": "P49840", "gene_name": "GSK3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49840", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49840" } ] }, { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "P49840", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49840" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "P49840", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49840" } ] } ] }, { "uniprot_ac": "P49841", "gene_name": "GSK3B", "activity": [ { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "P49841", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49841" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "P49841", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49841" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49841", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49841" } ] } ] }, { "uniprot_ac": "P50613", "gene_name": "CDK7", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "P50613", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50613" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P50613", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50613" } ] }, { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P50613", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50613" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P50613", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50613" } ] } ] }, { "uniprot_ac": "P50750", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P50750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50750" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P50750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50750" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "P50750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50750" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P50750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50750" } ] } ] }, { "uniprot_ac": "P50873", "gene_name": "MRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P50873", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50873" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P50873", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50873" } ] } ] }, { "uniprot_ac": "P51123", "gene_name": "Taf1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P51123", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51123" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P51123", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51123" } ] } ] }, { "uniprot_ac": "P51617", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P51617", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51617" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P51617", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51617" } ] } ] }, { "uniprot_ac": "P51668", "gene_name": "UBE2D1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P51668", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51668" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P51668", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51668" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P51668", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51668" } ] } ] }, { "uniprot_ac": "P51812", "gene_name": "RPS6KA3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P51812", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51812" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P51812", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51812" } ] } ] }, { "uniprot_ac": "P51817", "gene_name": "PRKX", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P51817", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51817" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P51817", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51817" } ] } ] }, { "uniprot_ac": "P51952", "gene_name": "Cdk7", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P51952", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51952" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "P51952", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51952" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P51952", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51952" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P51952", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51952" } ] } ] }, { "uniprot_ac": "P51954", "gene_name": "Nek1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P51954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51954" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P51954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51954" } ] } ] }, { "uniprot_ac": "P51955", "gene_name": "NEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P51955", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51955" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P51955", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51955" } ] } ] }, { "uniprot_ac": "P51956", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P51956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51956" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P51956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51956" } ] } ] }, { "uniprot_ac": "P51957", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P51957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51957" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P51957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51957" } ] } ] }, { "uniprot_ac": "P51965", "gene_name": "UBE2E1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P51965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51965" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P51965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51965" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P51965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51965" } ] } ] }, { "uniprot_ac": "P52304", "gene_name": "polo", "activity": [ { "ec_number": "2.7.11.21", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P52304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52304" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "P52304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52304" } ] } ] }, { "uniprot_ac": "P52480", "gene_name": "Pkm", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] } ] }, { "uniprot_ac": "P52564", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P52564", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52564" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P52564", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52564" } ] } ] }, { "uniprot_ac": "P53104", "gene_name": "ATG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P53104", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53104" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P53104", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53104" } ] } ] }, { "uniprot_ac": "P53233", "gene_name": "FMP48", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P53233", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53233" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P53233", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53233" } ] } ] }, { "uniprot_ac": "P53323", "gene_name": "BUD32", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P53323", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53323" } ] }, { "ec_number": "3.6.-.-", "activity": "", "evidence": [ { "id": "P53323", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53323" } ] } ] }, { "uniprot_ac": "P53349", "gene_name": "Map3k1", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P53349", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53349" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "P53349", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53349" } ] } ] }, { "uniprot_ac": "P53350", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P53350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53350" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "P53350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53350" } ] } ] }, { "uniprot_ac": "P53351", "gene_name": "Plk2", "activity": [ { "ec_number": "2.7.11.21", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P53351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53351" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "P53351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53351" } ] } ] }, { "uniprot_ac": "P53355", "gene_name": "DAPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P53355", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53355" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P53355", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53355" } ] } ] }, { "uniprot_ac": "P53599", "gene_name": "SSK2", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P53599", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53599" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "P53599", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53599" } ] } ] }, { "uniprot_ac": "P53667", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P53667", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53667" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P53667", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53667" } ] } ] }, { "uniprot_ac": "P53668", "gene_name": "Limk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P53668", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53668" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P53668", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53668" } ] } ] }, { "uniprot_ac": "P53669", "gene_name": "Limk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P53669", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53669" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P53669", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53669" } ] } ] }, { "uniprot_ac": "P53670", "gene_name": "Limk2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P53670", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53670" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P53670", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53670" } ] } ] }, { "uniprot_ac": "P53671", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P53671", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53671" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P53671", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53671" } ] } ] }, { "uniprot_ac": "P53739", "gene_name": "FPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P53739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53739" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P53739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53739" } ] } ] }, { "uniprot_ac": "P53778", "gene_name": "MAPK12", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P53778", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53778" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P53778", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53778" } ] } ] }, { "uniprot_ac": "P53779", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P53779", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53779" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P53779", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53779" } ] } ] }, { "uniprot_ac": "P53894", "gene_name": "CBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P53894", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53894" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P53894", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53894" } ] } ] }, { "uniprot_ac": "P53974", "gene_name": "ARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P53974", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53974" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P53974", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53974" } ] } ] }, { "uniprot_ac": "P54199", "gene_name": "MPS1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P54199", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54199" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P54199", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54199" } ] } ] }, { "uniprot_ac": "P54265", "gene_name": "Dmpk", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P54265", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54265" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P54265", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54265" } ] } ] }, { "uniprot_ac": "P54360", "gene_name": "fj", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P54360", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54360" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P54360", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54360" } ] } ] }, { "uniprot_ac": "P54367", "gene_name": "CkIalpha", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P54367", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54367" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P54367", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54367" } ] } ] }, { "uniprot_ac": "P54644", "gene_name": "pkbA", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P54644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54644" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P54644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54644" } ] } ] }, { "uniprot_ac": "P54645", "gene_name": "Prkaa1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P54645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54645" } ] }, { "ec_number": "2.7.11.31", "activity": "ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase].", "evidence": [ { "id": "P54645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54645" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P54645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54645" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "P54645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54645" } ] }, { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "P54645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54645" } ] } ] }, { "uniprot_ac": "P54646", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P54646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54646" } ] }, { "ec_number": "2.7.11.31", "activity": "ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase].", "evidence": [ { "id": "P54646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54646" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P54646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54646" } ] } ] }, { "uniprot_ac": "P54685", "gene_name": "cdk7", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P54685", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54685" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "P54685", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54685" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P54685", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54685" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P54685", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54685" } ] } ] }, { "uniprot_ac": "P57058", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P57058", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57058" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P57058", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57058" } ] } ] }, { "uniprot_ac": "P57059", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P57059", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57059" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P57059", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57059" } ] } ] }, { "uniprot_ac": "P57078", "gene_name": "RIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P57078", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57078" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P57078", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57078" } ] } ] }, { "uniprot_ac": "P57760", "gene_name": "Stk16", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P57760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57760" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P57760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57760" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P57760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57760" } ] } ] }, { "uniprot_ac": "P58750", "gene_name": "Pim3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P58750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58750" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P58750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58750" } ] } ] }, { "uniprot_ac": "P58801", "gene_name": "Ripk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P58801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58801" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P58801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58801" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P58801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58801" } ] } ] }, { "uniprot_ac": "P59241", "gene_name": "Aurka", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P59241", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59241" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P59241", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59241" } ] } ] }, { "uniprot_ac": "P59895", "gene_name": "Nek6", "activity": [ { "ec_number": "2.7.11.34", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P59895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59895" } ] }, { "ec_number": "2.7.11.34", "activity": "", "evidence": [ { "id": "P59895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59895" } ] } ] }, { "uniprot_ac": "P61006", "gene_name": "RAB8A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P61006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61006" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61006" } ] } ] }, { "uniprot_ac": "P62491", "gene_name": "RAB11A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P62491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62491" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62491" } ] } ] }, { "uniprot_ac": "P62714", "gene_name": "PPP2CB", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P62714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62714" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P62714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62714" } ] } ] }, { "uniprot_ac": "P62820", "gene_name": "RAB1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P62820", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62820" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62820", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62820" } ] } ] }, { "uniprot_ac": "P63085", "gene_name": "Mapk1", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P63085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63085" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P63085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63085" } ] } ] }, { "uniprot_ac": "P63086", "gene_name": "Mapk1", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P63086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63086" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P63086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63086" } ] } ] }, { "uniprot_ac": "P63318", "gene_name": "Prkcg", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P63318", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63318" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P63318", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63318" } ] } ] }, { "uniprot_ac": "P63319", "gene_name": "Prkcg", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P63319", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63319" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P63319", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63319" } ] } ] }, { "uniprot_ac": "P67775", "gene_name": "PPP2CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P67775", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P67775" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P67775", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P67775" } ] } ] }, { "uniprot_ac": "P67999", "gene_name": "Rps6kb1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P67999", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P67999" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67999", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P67999" } ] } ] }, { "uniprot_ac": "P68181", "gene_name": "Prkacb", "activity": [ { "ec_number": "2.7.11.11", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P68181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68181" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P68181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68181" } ] } ] }, { "uniprot_ac": "P68182", "gene_name": "Prkacb", "activity": [ { "ec_number": "2.7.11.11", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P68182", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68182" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P68182", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68182" } ] } ] }, { "uniprot_ac": "P68363", "gene_name": "TUBA1B", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68363", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68363" } ] } ] }, { "uniprot_ac": "P68366", "gene_name": "TUBA4A", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68366", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68366" } ] } ] }, { "uniprot_ac": "P68400", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P68400", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68400" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68400", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68400" } ] } ] }, { "uniprot_ac": "P68403", "gene_name": "Prkcb", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P68403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68403" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P68403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68403" } ] } ] }, { "uniprot_ac": "P68404", "gene_name": "Prkcb", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P68404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68404" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P68404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68404" } ] } ] }, { "uniprot_ac": "P70218", "gene_name": "Map4k1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P70218", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70218" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P70218", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70218" } ] } ] }, { "uniprot_ac": "P70236", "gene_name": "Map2k6", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P70236", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70236" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P70236", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70236" } ] } ] }, { "uniprot_ac": "P70268", "gene_name": "Pkn1", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P70268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70268" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P70268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70268" } ] } ] }, { "uniprot_ac": "P70335", "gene_name": "Rock1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P70335", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70335" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P70335", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70335" } ] } ] }, { "uniprot_ac": "P70336", "gene_name": "Rock2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P70336", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70336" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P70336", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70336" } ] } ] }, { "uniprot_ac": "P70618", "gene_name": "Mapk14", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P70618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70618" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P70618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70618" } ] } ] }, { "uniprot_ac": "P78362", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P78362", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78362" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P78362", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78362" } ] } ] }, { "uniprot_ac": "P78368", "gene_name": "CSNK1G2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P78368", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78368" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P78368", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78368" } ] } ] }, { "uniprot_ac": "P78527", "gene_name": "PRKDC", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P78527", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78527" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P78527", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78527" } ] } ] }, { "uniprot_ac": "P79621", "gene_name": "Ciita", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P79621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P79621" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "P79621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P79621" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P79621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P79621" } ] } ] }, { "uniprot_ac": "P80192", "gene_name": "MAP3K9", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P80192", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80192" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "P80192", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80192" } ] } ] }, { "uniprot_ac": "P83098", "gene_name": "Stlk", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P83098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83098" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P83098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83098" } ] } ] }, { "uniprot_ac": "P83099", "gene_name": "Pkcdelta", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P83099", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83099" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P83099", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83099" } ] }, { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "P83099", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83099" } ] } ] }, { "uniprot_ac": "P83100", "gene_name": "p38c", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P83100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83100" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P83100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83100" } ] } ] }, { "uniprot_ac": "P83102", "gene_name": "Dyrk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P83102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83102" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P83102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83102" } ] } ] }, { "uniprot_ac": "P83103", "gene_name": "Haspin", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P83103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83103" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P83103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83103" } ] } ] }, { "uniprot_ac": "P83104", "gene_name": "Takl1", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P83104", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83104" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "P83104", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83104" } ] } ] }, { "uniprot_ac": "P83510", "gene_name": "Tnik", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P83510", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83510" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P83510", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83510" } ] } ] }, { "uniprot_ac": "P83741", "gene_name": "Wnk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P83741", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83741" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P83741", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83741" } ] } ] }, { "uniprot_ac": "P92208", "gene_name": "bsk", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P92208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P92208" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P92208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P92208" } ] } ] }, { "uniprot_ac": "P97313", "gene_name": "Prkdc", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P97313", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97313" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P97313", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97313" } ] } ] }, { "uniprot_ac": "P97343", "gene_name": "Uhmk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P97343", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97343" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P97343", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97343" } ] } ] }, { "uniprot_ac": "P97377", "gene_name": "Cdk2", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P97377", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97377" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P97377", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97377" } ] } ] }, { "uniprot_ac": "P97477", "gene_name": "Aurka", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P97477", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97477" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P97477", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97477" } ] } ] }, { "uniprot_ac": "P97633", "gene_name": "Csnk1a1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P97633", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97633" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P97633", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97633" } ] } ] }, { "uniprot_ac": "P97756", "gene_name": "Camkk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P97756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97756" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P97756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97756" } ] }, { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P97756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97756" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "P97756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97756" } ] } ] }, { "uniprot_ac": "P97820", "gene_name": "Map4k4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P97820", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97820" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P97820", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97820" } ] } ] }, { "uniprot_ac": "P97874", "gene_name": "Gak", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P97874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97874" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P97874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97874" } ] } ] }, { "uniprot_ac": "P97924", "gene_name": "Kalrn", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P97924", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97924" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P97924", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97924" } ] } ] }, { "uniprot_ac": "Q00168", "gene_name": "CaMKII", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q00168", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00168" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q00168", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00168" } ] } ] }, { "uniprot_ac": "Q00526", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q00526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00526" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q00526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00526" } ] } ] }, { "uniprot_ac": "Q00532", "gene_name": "CDKL1", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q00532", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00532" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q00532", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00532" } ] } ] }, { "uniprot_ac": "Q00534", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q00534", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00534" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q00534", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00534" } ] } ] }, { "uniprot_ac": "Q00535", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q00535", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00535" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q00535", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00535" } ] } ] }, { "uniprot_ac": "Q00536", "gene_name": "CDK16", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q00536", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00536" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q00536", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00536" } ] } ] }, { "uniprot_ac": "Q00537", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q00537", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00537" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q00537", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00537" } ] } ] }, { "uniprot_ac": "Q00772", "gene_name": "SLT2", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q00772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00772" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q00772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00772" } ] } ] }, { "uniprot_ac": "Q00972", "gene_name": "Bckdk", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q00972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00972" } ] }, { "ec_number": "2.7.11.4", "activity": "ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] = ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase].", "evidence": [ { "id": "Q00972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00972" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q00972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00972" } ] }, { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q00972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00972" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q00972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00972" } ] } ] }, { "uniprot_ac": "Q00987", "gene_name": "MDM2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q00987", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00987" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q00987", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00987" } ] } ] }, { "uniprot_ac": "Q01389", "gene_name": "BCK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q01389", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01389" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01389", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01389" } ] } ] }, { "uniprot_ac": "Q01919", "gene_name": "KIN4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q01919", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01919" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01919", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01919" } ] } ] }, { "uniprot_ac": "Q01986", "gene_name": "Map2k1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q01986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01986" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q01986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01986" } ] } ] }, { "uniprot_ac": "Q02111", "gene_name": "Prkcq", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q02111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02111" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q02111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02111" } ] } ] }, { "uniprot_ac": "Q02156", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q02156", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02156" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q02156", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02156" } ] } ] }, { "uniprot_ac": "Q02720", "gene_name": "casK", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q02720", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02720" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02720", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02720" } ] } ] }, { "uniprot_ac": "Q02750", "gene_name": "MAP2K1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q02750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02750" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q02750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02750" } ] } ] }, { "uniprot_ac": "Q02779", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q02779", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02779" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "Q02779", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02779" } ] } ] }, { "uniprot_ac": "Q02956", "gene_name": "Prkcz", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q02956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02956" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q02956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02956" } ] } ] }, { "uniprot_ac": "Q03002", "gene_name": "FRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q03002", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03002" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q03002", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03002" } ] } ] }, { "uniprot_ac": "Q03042", "gene_name": "Pkg21D", "activity": [ { "ec_number": "2.7.11.12", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q03042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03042" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "Q03042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03042" } ] } ] }, { "uniprot_ac": "Q03043", "gene_name": "for", "activity": [ { "ec_number": "2.7.11.12", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q03043", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03043" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "Q03043", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03043" } ] } ] }, { "uniprot_ac": "Q03114", "gene_name": "Cdk5", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q03114", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03114" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q03114", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03114" } ] } ] }, { "uniprot_ac": "Q03141", "gene_name": "Mark3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q03141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03141" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q03141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03141" } ] } ] }, { "uniprot_ac": "Q03147", "gene_name": "Cdk7", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q03147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03147" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q03147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03147" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q03147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03147" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q03147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03147" } ] } ] }, { "uniprot_ac": "Q03306", "gene_name": "PKH3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q03306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03306" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q03306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03306" } ] } ] }, { "uniprot_ac": "Q03407", "gene_name": "PKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q03407", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03407" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q03407", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03407" } ] } ] }, { "uniprot_ac": "Q03497", "gene_name": "STE20", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q03497", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03497" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q03497", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03497" } ] } ] }, { "uniprot_ac": "Q03533", "gene_name": "TDA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q03533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03533" } ] } ] }, { "uniprot_ac": "Q03656", "gene_name": "SKY1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q03656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03656" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q03656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03656" } ] } ] }, { "uniprot_ac": "Q03785", "gene_name": "VHS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q03785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03785" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q03785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03785" } ] } ] }, { "uniprot_ac": "Q03957", "gene_name": "CTK1", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q03957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03957" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q03957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03957" } ] } ] }, { "uniprot_ac": "Q03963", "gene_name": "Eif2ak2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03963" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q03963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03963" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q03963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03963" } ] } ] }, { "uniprot_ac": "Q04735", "gene_name": "Cdk16", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q04735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04735" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q04735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04735" } ] } ] }, { "uniprot_ac": "Q04759", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q04759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04759" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q04759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04759" } ] } ] }, { "uniprot_ac": "Q04859", "gene_name": "Mak", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q04859", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04859" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q04859", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04859" } ] } ] }, { "uniprot_ac": "Q04899", "gene_name": "Cdk18", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q04899", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04899" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q04899", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04899" } ] } ] }, { "uniprot_ac": "Q05512", "gene_name": "Mark2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q05512", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05512" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q05512", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05512" } ] }, { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "Q05512", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05512" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "Q05512", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05512" } ] } ] }, { "uniprot_ac": "Q05513", "gene_name": "PRKCZ", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q05513", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05513" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q05513", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05513" } ] } ] }, { "uniprot_ac": "Q05652", "gene_name": "pll", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q05652", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05652" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q05652", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05652" } ] }, { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q05652", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05652" } ] } ] }, { "uniprot_ac": "Q05655", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q05655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05655" } ] }, { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q05655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05655" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q05655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05655" } ] } ] }, { "uniprot_ac": "Q06098", "gene_name": "ISR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q06098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06098" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q06098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06098" } ] } ] }, { "uniprot_ac": "Q06226", "gene_name": "Sgk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q06226", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06226" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q06226", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06226" } ] } ] }, { "uniprot_ac": "Q06486", "gene_name": "Csnk1d", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q06486", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06486" } ] }, { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "Q06486", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06486" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q06486", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06486" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "Q06486", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06486" } ] } ] }, { "uniprot_ac": "Q07002", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q07002", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07002" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q07002", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07002" } ] } ] }, { "uniprot_ac": "Q07174", "gene_name": "Map3k8", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q07174", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07174" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "Q07174", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07174" } ] } ] }, { "uniprot_ac": "Q07832", "gene_name": "Plk1", "activity": [ { "ec_number": "2.7.11.21", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q07832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07832" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q07832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07832" } ] } ] }, { "uniprot_ac": "Q07912", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q07912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07912" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q07912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07912" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q07912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07912" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q07912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07912" } ] } ] }, { "uniprot_ac": "Q08217", "gene_name": "PSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q08217", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08217" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08217", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08217" } ] } ] }, { "uniprot_ac": "Q08732", "gene_name": "HRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q08732", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08732" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08732", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08732" } ] } ] }, { "uniprot_ac": "Q09013", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q09013", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09013" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q09013", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09013" } ] } ] }, { "uniprot_ac": "Q09137", "gene_name": "Prkaa2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q09137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09137" } ] }, { "ec_number": "2.7.11.31", "activity": "ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase].", "evidence": [ { "id": "Q09137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09137" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q09137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09137" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "Q09137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09137" } ] } ] }, { "uniprot_ac": "Q0KHQ5", "gene_name": "Tao", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q0KHQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q0KHQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0KHQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q0KHQ5" } ] } ] }, { "uniprot_ac": "Q0KHT7", "gene_name": "Drak", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q0KHT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q0KHT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0KHT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q0KHT7" } ] } ] }, { "uniprot_ac": "Q0KHV6", "gene_name": "Pink1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q0KHV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q0KHV6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0KHV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q0KHV6" } ] } ] }, { "uniprot_ac": "Q0KL02", "gene_name": "Trio", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q0KL02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q0KL02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0KL02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q0KL02" } ] } ] }, { "uniprot_ac": "Q12003", "gene_name": "ENV7", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q12003", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12003" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q12003", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12003" } ] } ] }, { "uniprot_ac": "Q12100", "gene_name": "RTK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q12100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12100" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q12100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12100" } ] } ] }, { "uniprot_ac": "Q12152", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q12152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12152" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q12152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12152" } ] } ] }, { "uniprot_ac": "Q12196", "gene_name": "RIO1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q12196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12196" } ] }, { "ec_number": "3.6.3.-", "activity": "", "evidence": [ { "id": "Q12196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12196" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q12196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12196" } ] } ] }, { "uniprot_ac": "Q12222", "gene_name": "YGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q12222", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12222" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q12222", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12222" } ] } ] }, { "uniprot_ac": "Q12236", "gene_name": "PKH2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q12236", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12236" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q12236", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12236" } ] } ] }, { "uniprot_ac": "Q12263", "gene_name": "GIN4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q12263", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12263" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q12263", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12263" } ] } ] }, { "uniprot_ac": "Q12310", "gene_name": "PRR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q12310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12310" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q12310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12310" } ] } ] }, { "uniprot_ac": "Q12469", "gene_name": "SKM1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q12469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12469" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q12469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12469" } ] } ] }, { "uniprot_ac": "Q12505", "gene_name": "SKS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q12505", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12505" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q12505", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12505" } ] } ] }, { "uniprot_ac": "Q12851", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q12851", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12851" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q12851", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12851" } ] } ] }, { "uniprot_ac": "Q12852", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q12852", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12852" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "Q12852", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12852" } ] } ] }, { "uniprot_ac": "Q13043", "gene_name": "STK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13043", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13043" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q13043", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13043" } ] } ] }, { "uniprot_ac": "Q13131", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13131" } ] }, { "ec_number": "2.7.11.31", "activity": "ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase].", "evidence": [ { "id": "Q13131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13131" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "Q13131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13131" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q13131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13131" } ] }, { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "Q13131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13131" } ] } ] }, { "uniprot_ac": "Q13153", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13153", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13153" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q13153", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13153" } ] } ] }, { "uniprot_ac": "Q13163", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13163" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q13163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13163" } ] } ] }, { "uniprot_ac": "Q13164", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13164", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13164" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q13164", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13164" } ] } ] }, { "uniprot_ac": "Q13177", "gene_name": "PAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13177" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q13177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13177" } ] } ] }, { "uniprot_ac": "Q13188", "gene_name": "STK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13188", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13188" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q13188", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13188" } ] } ] }, { "uniprot_ac": "Q13233", "gene_name": "MAP3K1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q13233", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13233" } ] }, { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13233", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13233" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "Q13233", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13233" } ] } ] }, { "uniprot_ac": "Q13237", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13237", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13237" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "Q13237", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13237" } ] } ] }, { "uniprot_ac": "Q13315", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13315", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13315" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q13315", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13315" } ] } ] }, { "uniprot_ac": "Q13418", "gene_name": "ILK", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13418", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13418" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q13418", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13418" } ] } ] }, { "uniprot_ac": "Q13464", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13464", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13464" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q13464", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13464" } ] } ] }, { "uniprot_ac": "Q13523", "gene_name": "PRPF4B", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13523" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q13523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13523" } ] } ] }, { "uniprot_ac": "Q13535", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13535", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13535" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q13535", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13535" } ] } ] }, { "uniprot_ac": "Q13546", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13546", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13546" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q13546", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13546" } ] } ] }, { "uniprot_ac": "Q13547", "gene_name": "HDAC1", "activity": [ { "ec_number": "3.5.1.98", "activity": "H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone].", "evidence": [ { "id": "Q13547", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13547" } ] }, { "ec_number": "3.5.1.98", "activity": "", "evidence": [ { "id": "Q13547", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13547" } ] }, { "ec_number": "3.5.1.-", "activity": "", "evidence": [ { "id": "Q13547", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13547" } ] } ] }, { "uniprot_ac": "Q13554", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13554", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13554" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q13554", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13554" } ] } ] }, { "uniprot_ac": "Q13555", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13555" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q13555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13555" } ] } ] }, { "uniprot_ac": "Q13557", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13557", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13557" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q13557", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13557" } ] } ] }, { "uniprot_ac": "Q13627", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q13627", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13627" } ] }, { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13627", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13627" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q13627", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13627" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q13627", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13627" } ] } ] }, { "uniprot_ac": "Q13976", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13976", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13976" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "Q13976", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13976" } ] } ] }, { "uniprot_ac": "Q14004", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q14004", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14004" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q14004", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14004" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q14004", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14004" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q14004", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14004" } ] } ] }, { "uniprot_ac": "Q14012", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q14012", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14012" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q14012", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14012" } ] } ] }, { "uniprot_ac": "Q14296", "gene_name": "FASTK", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q14296", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14296" } ] }, { "ec_number": "2.7.11.8", "activity": "ATP + L-threonyl-[Fas-activated protein] = ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein].", "evidence": [ { "id": "Q14296", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14296" } ] }, { "ec_number": "2.7.11.8", "activity": "", "evidence": [ { "id": "Q14296", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14296" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q14296", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14296" } ] } ] }, { "uniprot_ac": "Q14680", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14680" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14680" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14680" } ] } ] }, { "uniprot_ac": "Q14693", "gene_name": "LPIN1", "activity": [ { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "Q14693", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14693" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "Q14693", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14693" } ] } ] }, { "uniprot_ac": "Q14739", "gene_name": "LBR", "activity": [ { "ec_number": "1.3.1.70", "activity": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH.", "evidence": [ { "id": "Q14739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14739" } ] }, { "ec_number": "1.3.1.70", "activity": "", "evidence": [ { "id": "Q14739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14739" } ] } ] }, { "uniprot_ac": "Q14AX6", "gene_name": "Cdk12", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q14AX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14AX6" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q14AX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14AX6" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q14AX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14AX6" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q14AX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14AX6" } ] } ] }, { "uniprot_ac": "Q15131", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q15131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15131" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q15131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15131" } ] } ] }, { "uniprot_ac": "Q15139", "gene_name": "PRKD1", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q15139", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15139" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q15139", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15139" } ] } ] }, { "uniprot_ac": "Q15208", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q15208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15208" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q15208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15208" } ] } ] }, { "uniprot_ac": "Q15349", "gene_name": "RPS6KA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q15349", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15349" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q15349", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15349" } ] } ] }, { "uniprot_ac": "Q15418", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q15418", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15418" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q15418", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15418" } ] } ] }, { "uniprot_ac": "Q15569", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q15569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15569" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q15569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15569" } ] } ] }, { "uniprot_ac": "Q15759", "gene_name": "MAPK11", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q15759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15759" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q15759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15759" } ] } ] }, { "uniprot_ac": "Q15772", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q15772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15772" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q15772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15772" } ] } ] }, { "uniprot_ac": "Q15831", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q15831", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15831" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q15831", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15831" } ] } ] }, { "uniprot_ac": "Q16512", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q16512", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16512" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q16512", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16512" } ] } ] }, { "uniprot_ac": "Q16513", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q16513", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16513" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q16513", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16513" } ] } ] }, { "uniprot_ac": "Q16539", "gene_name": "MAPK14", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q16539", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16539" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q16539", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16539" } ] } ] }, { "uniprot_ac": "Q16566", "gene_name": "CAMK4", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q16566", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16566" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q16566", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16566" } ] } ] }, { "uniprot_ac": "Q16584", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q16584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16584" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "Q16584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16584" } ] } ] }, { "uniprot_ac": "Q16644", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q16644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16644" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q16644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16644" } ] } ] }, { "uniprot_ac": "Q16659", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q16659", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16659" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q16659", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16659" } ] } ] }, { "uniprot_ac": "Q16763", "gene_name": "UBE2S", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q16763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16763" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q16763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16763" } ] } ] }, { "uniprot_ac": "Q16816", "gene_name": "PHKG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q16816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16816" } ] }, { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "Q16816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16816" } ] }, { "ec_number": "2.7.11.19", "activity": "2 ATP + phosphorylase b = 2 ADP + phosphorylase a.", "evidence": [ { "id": "Q16816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16816" } ] }, { "ec_number": "2.7.11.19", "activity": "", "evidence": [ { "id": "Q16816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16816" } ] } ] }, { "uniprot_ac": "Q1EG27", "gene_name": "Myo3b", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q1EG27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1EG27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1EG27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1EG27" } ] } ] }, { "uniprot_ac": "Q1HKZ5", "gene_name": "Map3k13", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q1HKZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1HKZ5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "Q1HKZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1HKZ5" } ] } ] }, { "uniprot_ac": "Q1ZXC8", "gene_name": "pXi", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q1ZXC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1ZXC8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1ZXC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1ZXC8" } ] } ] }, { "uniprot_ac": "Q1ZXD6", "gene_name": "roco5", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q1ZXD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1ZXD6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1ZXD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1ZXD6" } ] } ] }, { "uniprot_ac": "Q1ZXH2", "gene_name": "fhkB", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q1ZXH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1ZXH2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1ZXH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1ZXH2" } ] } ] }, { "uniprot_ac": "Q1ZXI5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q1ZXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1ZXI5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1ZXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1ZXI5" } ] } ] }, { "uniprot_ac": "Q1ZXR2", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q1ZXR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1ZXR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1ZXR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1ZXR2" } ] } ] }, { "uniprot_ac": "Q23915", "gene_name": "kinX", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q23915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23915" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q23915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23915" } ] } ] }, { "uniprot_ac": "Q23977", "gene_name": "hep", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q23977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23977" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q23977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23977" } ] } ] }, { "uniprot_ac": "Q24210", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q24210", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24210" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q24210", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24210" } ] } ] }, { "uniprot_ac": "Q24216", "gene_name": "Cdk7", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q24216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24216" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q24216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24216" } ] } ] }, { "uniprot_ac": "Q24324", "gene_name": "Dsor1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q24324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24324" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q24324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24324" } ] } ] }, { "uniprot_ac": "Q2M2I8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q2M2I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2M2I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2M2I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2M2I8" } ] } ] }, { "uniprot_ac": "Q2NKX8", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q2NKX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2NKX8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2NKX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2NKX8" } ] } ] }, { "uniprot_ac": "Q2NL51", "gene_name": "Gsk3a", "activity": [ { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "Q2NL51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2NL51" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "Q2NL51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2NL51" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q2NL51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2NL51" } ] } ] }, { "uniprot_ac": "Q38SD2", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q38SD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q38SD2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q38SD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q38SD2" } ] } ] }, { "uniprot_ac": "Q3MJK5", "gene_name": "Cdk12", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q3MJK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MJK5" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q3MJK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MJK5" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q3MJK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MJK5" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q3MJK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MJK5" } ] } ] }, { "uniprot_ac": "Q3TYD6", "gene_name": "Lmtk2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q3TYD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TYD6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3TYD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TYD6" } ] } ] }, { "uniprot_ac": "Q3TZA2", "gene_name": "Cdkl4", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q3TZA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TZA2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q3TZA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TZA2" } ] } ] }, { "uniprot_ac": "Q3U1V8", "gene_name": "Map3k9", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q3U1V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U1V8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "Q3U1V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U1V8" } ] } ] }, { "uniprot_ac": "Q3U214", "gene_name": "Mast3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q3U214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U214" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3U214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U214" } ] } ] }, { "uniprot_ac": "Q3U3Q1", "gene_name": "Ulk3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q3U3Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U3Q1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3U3Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U3Q1" } ] } ] }, { "uniprot_ac": "Q3UGM2", "gene_name": "Nek10", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q3UGM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UGM2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3UGM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UGM2" } ] } ] }, { "uniprot_ac": "Q3UH66", "gene_name": "Wnk2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q3UH66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UH66" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3UH66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UH66" } ] } ] }, { "uniprot_ac": "Q3UHC2", "gene_name": "Lrrk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q3UHC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UHC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3UHC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UHC2" } ] } ] }, { "uniprot_ac": "Q3UHJ0", "gene_name": "Aak1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q3UHJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UHJ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3UHJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UHJ0" } ] } ] }, { "uniprot_ac": "Q3ULB5", "gene_name": "Pak6", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q3ULB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3ULB5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3ULB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3ULB5" } ] } ] }, { "uniprot_ac": "Q3UMM4", "gene_name": "Cdk10", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q3UMM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UMM4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q3UMM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UMM4" } ] } ] }, { "uniprot_ac": "Q3UMW7", "gene_name": "Mapkapk3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q3UMW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UMW7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3UMW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UMW7" } ] } ] }, { "uniprot_ac": "Q3UT86", "gene_name": "Gm5891", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q3UT86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UT86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3UT86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UT86" } ] } ] }, { "uniprot_ac": "Q3UTA8", "gene_name": "Gm4567", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q3UTA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UTA8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3UTA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UTA8" } ] } ] }, { "uniprot_ac": "Q3UTQ8", "gene_name": "Cdkl5", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q3UTQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UTQ8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q3UTQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UTQ8" } ] } ] }, { "uniprot_ac": "Q3UU96", "gene_name": "Cdc42bpa", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q3UU96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UU96" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3UU96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UU96" } ] } ] }, { "uniprot_ac": "Q3UVC0", "gene_name": "Ksr2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q3UVC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UVC0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3UVC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UVC0" } ] } ] }, { "uniprot_ac": "Q3UVR3", "gene_name": "Ttbk2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q3UVR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UVR3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3UVR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UVR3" } ] } ] }, { "uniprot_ac": "Q3V016", "gene_name": "Hipk4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q3V016", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3V016" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3V016", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3V016" } ] } ] }, { "uniprot_ac": "Q3V129", "gene_name": "Ulk4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q3V129", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3V129" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3V129", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3V129" } ] } ] }, { "uniprot_ac": "Q3V3A1", "gene_name": "Cdk15", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q3V3A1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3V3A1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q3V3A1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3V3A1" } ] } ] }, { "uniprot_ac": "Q4FZD7", "gene_name": "Plk5", "activity": [ { "ec_number": "2.7.11.21", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q4FZD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4FZD7" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q4FZD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4FZD7" } ] } ] }, { "uniprot_ac": "Q4G050", "gene_name": "Mknk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q4G050", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4G050" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q4G050", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4G050" } ] } ] }, { "uniprot_ac": "Q4KLN3", "gene_name": "Srpk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q4KLN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KLN3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q4KLN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KLN3" } ] } ] }, { "uniprot_ac": "Q4KM34", "gene_name": "Cdk20", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q4KM34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KM34" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q4KM34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KM34" } ] } ] }, { "uniprot_ac": "Q4KM47", "gene_name": "Cdk10", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q4KM47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KM47" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q4KM47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KM47" } ] } ] }, { "uniprot_ac": "Q4KSH6", "gene_name": "Map2k4", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q4KSH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KSH6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q4KSH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KSH6" } ] } ] }, { "uniprot_ac": "Q4KSH7", "gene_name": "Map2k7", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q4KSH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KSH7" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q4KSH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KSH7" } ] } ] }, { "uniprot_ac": "Q4V793", "gene_name": "Hipk4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q4V793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4V793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q4V793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4V793" } ] } ] }, { "uniprot_ac": "Q4V8A3", "gene_name": "Dyrk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q4V8A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4V8A3" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4V8A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4V8A3" } ] } ] }, { "uniprot_ac": "Q52WX2", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q52WX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q52WX2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q52WX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q52WX2" } ] } ] }, { "uniprot_ac": "Q53UA7", "gene_name": "Taok3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q53UA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53UA7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q53UA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53UA7" } ] } ] }, { "uniprot_ac": "Q54B33", "gene_name": "pakE", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54B33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54B33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54B33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54B33" } ] } ] }, { "uniprot_ac": "Q54B48", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54B48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54B48" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54B48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54B48" } ] } ] }, { "uniprot_ac": "Q54BC9", "gene_name": "dyrk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54BC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54BC9" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q54BC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54BC9" } ] } ] }, { "uniprot_ac": "Q54BF0", "gene_name": "fhkA", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54BF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54BF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54BF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54BF0" } ] } ] }, { "uniprot_ac": "Q54C18", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54C18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54C18" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54C18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54C18" } ] } ] }, { "uniprot_ac": "Q54C38", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54C38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54C38" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54C38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54C38" } ] } ] }, { "uniprot_ac": "Q54C71", "gene_name": "kxcB", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54C71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54C71" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54C71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54C71" } ] } ] }, { "uniprot_ac": "Q54D75", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54D75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54D75" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q54D75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54D75" } ] } ] }, { "uniprot_ac": "Q54DC8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54DC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54DC8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54DC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54DC8" } ] } ] }, { "uniprot_ac": "Q54DF2", "gene_name": "mrkA", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54DF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54DF2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54DF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54DF2" } ] } ] }, { "uniprot_ac": "Q54DK3", "gene_name": "cdc7", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54DK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54DK3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54DK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54DK3" } ] } ] }, { "uniprot_ac": "Q54DY0", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54DY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54DY0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54DY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54DY0" } ] } ] }, { "uniprot_ac": "Q54E34", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + 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"https://www.uniprot.org/uniprot/Q54EM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54EM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54EM1" } ] } ] }, { "uniprot_ac": "Q54ER4", "gene_name": "atr1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54ER4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54ER4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54ER4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54ER4" } ] } ] }, { "uniprot_ac": "Q54ET3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54ET3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54ET3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54ET3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54ET3" } ] } ] }, { "uniprot_ac": "Q54EY4", "gene_name": "dst3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54EY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54EY4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54EY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54EY4" } ] } ] }, { "uniprot_ac": "Q54F40", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54F40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54F40" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54F40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54F40" } ] } ] }, { "uniprot_ac": "Q54FH3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54FH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54FH3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54FH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54FH3" } ] } ] }, { "uniprot_ac": "Q54FR9", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54FR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54FR9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54FR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54FR9" } ] } ] }, { "uniprot_ac": "Q54G43", "gene_name": "shkE", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + 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"Q54HS0", "gene_name": "nek4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54HS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54HS0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54HS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54HS0" } ] } ] }, { "uniprot_ac": "Q54I36", "gene_name": "pyk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54I36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54I36" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q54I36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54I36" } ] } ] }, { "uniprot_ac": "Q54IE8", "gene_name": "irlE", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + 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"Q54JC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54JC7" } ] } ] }, { "uniprot_ac": "Q54JG7", "gene_name": "dst4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54JG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54JG7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54JG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54JG7" } ] } ] }, { "uniprot_ac": "Q54JQ1", "gene_name": "mkcC", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54JQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54JQ1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54JQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54JQ1" } ] } ] }, { "uniprot_ac": 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"https://www.uniprot.org/uniprot/Q54LU8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54LU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54LU8" } ] } ] }, { "uniprot_ac": "Q54M77", "gene_name": "roco8", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54M77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54M77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54M77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54M77" } ] } ] }, { "uniprot_ac": "Q54MH0", "gene_name": "fhkD", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54MH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54MH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54MH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54MH0" } ] } ] }, { "uniprot_ac": "Q54MV2", "gene_name": "mrkB", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54MV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54MV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54MV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54MV2" } ] } ] }, { "uniprot_ac": "Q54MY9", "gene_name": "mkcA", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54MY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54MY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54MY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54MY9" } ] } ] }, { "uniprot_ac": "Q54P26", "gene_name": "samkB", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54P26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54P26" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54P26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54P26" } ] } ] }, { "uniprot_ac": "Q54P47", "gene_name": "ndrC", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54P47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54P47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54P47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54P47" } ] } ] }, { "uniprot_ac": "Q54PK8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + 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"https://www.uniprot.org/uniprot/Q54PX0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q54PX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54PX0" } ] } ] }, { "uniprot_ac": "Q54Q69", "gene_name": "dhkG", "activity": [ { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "Q54Q69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54Q69" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54Q69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54Q69" } ] } ] }, { "uniprot_ac": "Q54QB1", "gene_name": "erkB", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54QB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QB1" } ] }, { 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"Q55EI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55EI8" } ] } ] }, { "uniprot_ac": "Q55F45", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q55F45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55F45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q55F45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55F45" } ] } ] }, { "uniprot_ac": "Q55FJ6", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q55FJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55FJ6" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q55FJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55FJ6" } ] } ] }, { "uniprot_ac": "Q55FS2", "gene_name": "krsB", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q55FS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55FS2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q55FS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55FS2" } ] } ] }, { "uniprot_ac": "Q55FT4", "gene_name": "tsuA", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q55FT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55FT4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q55FT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55FT4" } ] } ] }, { "uniprot_ac": "Q55FV4", "gene_name": "fnkB", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q55FV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55FV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q55FV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55FV4" } ] } ] }, { "uniprot_ac": "Q55FV5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q55FV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55FV5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q55FV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55FV5" } ] } ] }, { "uniprot_ac": "Q55GC2", "gene_name": "dst2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q55GC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55GC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q55GC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55GC2" } ] } ] }, { "uniprot_ac": "Q55GE6", "gene_name": "roco7", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q55GE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55GE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q55GE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55GE6" } ] } ] }, { "uniprot_ac": "Q55GG4", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q55GG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55GG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q55GG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55GG4" } ] } ] }, { "uniprot_ac": "Q55GJ2", "gene_name": "ireA", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q55GJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55GJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q55GJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55GJ2" } ] } ] }, { "uniprot_ac": "Q55GS4", "gene_name": "cdk10", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q55GS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55GS4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q55GS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55GS4" } ] } ] }, { "uniprot_ac": "Q55GU0", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q55GU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55GU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q55GU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55GU0" } ] } ] }, { "uniprot_ac": "Q55GV3", "gene_name": "pakC", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q55GV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55GV3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q55GV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55GV3" } ] } ] }, { "uniprot_ac": "Q56UN5", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q56UN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q56UN5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q56UN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q56UN5" } ] }, { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q56UN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q56UN5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "Q56UN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q56UN5" } ] } ] }, { "uniprot_ac": "Q59H18", "gene_name": "TNNI3K", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q59H18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q59H18" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q59H18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q59H18" } ] } ] }, { "uniprot_ac": "Q5EAK6", "gene_name": "tefu", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5EAK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5EAK6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5EAK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5EAK6" } ] } ] }, { "uniprot_ac": "Q5EG47", "gene_name": "Prkaa1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5EG47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5EG47" } ] }, { "ec_number": "2.7.11.31", "activity": "ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase].", "evidence": [ { "id": "Q5EG47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5EG47" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "Q5EG47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5EG47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5EG47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5EG47" } ] }, { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "Q5EG47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5EG47" } ] } ] }, { "uniprot_ac": "Q5F2E8", "gene_name": "Taok1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5F2E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5F2E8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5F2E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5F2E8" } ] } ] }, { "uniprot_ac": "Q5GIG6", "gene_name": "Tnni3k", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5GIG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5GIG6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5GIG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5GIG6" } ] } ] }, { "uniprot_ac": "Q5MAI5", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5MAI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5MAI5" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5MAI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5MAI5" } ] } ] }, { "uniprot_ac": "Q5MJS3", "gene_name": "Fam20c", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5MJS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5MJS3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5MJS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5MJS3" } ] } ] }, { "uniprot_ac": "Q5MPA9", "gene_name": "Dclk2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5MPA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5MPA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5MPA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5MPA9" } ] } ] }, { "uniprot_ac": "Q5PQT0", "gene_name": "Pask", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5PQT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5PQT0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5PQT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5PQT0" } ] } ] }, { "uniprot_ac": "Q5RJI5", "gene_name": "Brsk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5RJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5RJI5" } ] }, { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "Q5RJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5RJI5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5RJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5RJI5" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "Q5RJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5RJI5" } ] } ] }, { "uniprot_ac": "Q5RKH1", "gene_name": "Prpf4b", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5RKH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5RKH1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5RKH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5RKH1" } ] } ] }, { "uniprot_ac": "Q5S006", "gene_name": "Lrrk2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5S006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5S006" } ] }, { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5S006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5S006" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5S006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5S006" } ] } ] }, { "uniprot_ac": "Q5S007", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5S007", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5S007" } ] }, { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q5S007", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5S007" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5S007", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5S007" } ] } ] }, { "uniprot_ac": "Q5SUV5", "gene_name": "Mylk4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5SUV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5SUV5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5SUV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5SUV5" } ] } ] }, { "uniprot_ac": "Q5SYL1", "gene_name": "Rskr", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5SYL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5SYL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5SYL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5SYL1" } ] } ] }, { "uniprot_ac": "Q5TCX8", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5TCX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5TCX8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "Q5TCX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5TCX8" } ] } ] }, { "uniprot_ac": "Q5TCY1", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5TCY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5TCY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5TCY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5TCY1" } ] } ] }, { "uniprot_ac": "Q5U2N4", "gene_name": "Mknk2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5U2N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U2N4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5U2N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U2N4" } ] } ] }, { "uniprot_ac": "Q5U2X5", "gene_name": "Tnk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q5U2X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U2X5" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q5U2X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U2X5" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5U2X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U2X5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5U2X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U2X5" } ] } ] }, { "uniprot_ac": "Q5U452", "gene_name": "Trp53rka", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5U452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U452" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5U452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U452" } ] } ] }, { "uniprot_ac": "Q5U4C9", "gene_name": "Dyrk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5U4C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U4C9" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q5U4C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U4C9" } ] } ] }, { "uniprot_ac": "Q5VJL3", "gene_name": "gdt9", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5VJL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VJL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5VJL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VJL3" } ] } ] }, { "uniprot_ac": "Q5VST9", "gene_name": "OBSCN", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5VST9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VST9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5VST9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VST9" } ] } ] }, { "uniprot_ac": "Q5VT25", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5VT25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VT25" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5VT25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VT25" } ] } ] }, { "uniprot_ac": "Q5XIS9", "gene_name": "Prkd2", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5XIS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIS9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q5XIS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIS9" } ] } ] }, { "uniprot_ac": "Q5XIT0", "gene_name": "Cdkl2", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5XIT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIT0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5XIT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIT0" } ] } ] }, { "uniprot_ac": "Q5XJV6", "gene_name": "Lmtk3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5XJV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XJV6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5XJV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XJV6" } ] } ] }, { "uniprot_ac": "Q60592", "gene_name": "Mast2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q60592", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60592" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q60592", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60592" } ] } ] }, { "uniprot_ac": "Q60670", "gene_name": "Sik1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q60670", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60670" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q60670", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60670" } ] } ] }, { "uniprot_ac": "Q60700", "gene_name": "Map3k12", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q60700", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60700" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "Q60700", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60700" } ] } ] }, { "uniprot_ac": "Q60737", "gene_name": "Csnk2a1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q60737", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60737" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q60737", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60737" } ] } ] }, { "uniprot_ac": "Q60806", "gene_name": "Plk3", "activity": [ { "ec_number": "2.7.11.21", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q60806", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60806" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q60806", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60806" } ] } ] }, { "uniprot_ac": "Q60823", "gene_name": "Akt2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q60823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60823" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q60823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60823" } ] } ] }, { "uniprot_ac": "Q60855", "gene_name": "Ripk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q60855", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60855" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q60855", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60855" } ] } ] }, { "uniprot_ac": "Q61036", "gene_name": "Pak3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q61036", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61036" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q61036", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61036" } ] } ] }, 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L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q61097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61097" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q61097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61097" } ] } ] }, { "uniprot_ac": "Q61136", "gene_name": "Prpf4b", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q61136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61136" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q61136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61136" } ] } ] }, { "uniprot_ac": "Q61161", "gene_name": "Map4k2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q61161", "database": 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"UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61214" } ] } ] }, { "uniprot_ac": "Q61241", "gene_name": "Tssk1b", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q61241", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61241" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q61241", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61241" } ] } ] }, { "uniprot_ac": "Q61410", "gene_name": "Prkg2", "activity": [ { "ec_number": "2.7.11.12", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q61410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61410" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "Q61410", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61410" } ] } ] }, { "uniprot_ac": "Q61532", "gene_name": 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"gene_name": "Map3k7", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q62073", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62073" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "Q62073", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62073" } ] } ] }, { "uniprot_ac": "Q62074", "gene_name": "Prkci", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q62074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62074" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q62074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62074" } ] } ] }, { "uniprot_ac": "Q62101", "gene_name": "Prkd1", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q62101", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62101" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q62101", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62101" } ] } ] }, { "uniprot_ac": "Q62388", "gene_name": "Atm", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q62388", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62388" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q62388", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62388" } ] } ] }, { "uniprot_ac": "Q62406", "gene_name": "Irak1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q62406", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62406" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q62406", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62406" } ] } ] }, { "uniprot_ac": "Q62407", "gene_name": "Speg", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q62407", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62407" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q62407", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62407" } ] } ] }, { "uniprot_ac": "Q62673", "gene_name": "Plk1", "activity": [ { "ec_number": "2.7.11.21", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q62673", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62673" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q62673", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62673" } ] } ] }, { "uniprot_ac": "Q62726", "gene_name": "Cilk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q62726", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62726" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q62726", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62726" } ] } ] }, { "uniprot_ac": "Q62761", "gene_name": "Csnk1g1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q62761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62761" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q62761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62761" } ] } ] }, { "uniprot_ac": "Q62762", "gene_name": "Csnk1g2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q62762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62762" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q62762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62762" } ] } ] }, { "uniprot_ac": "Q62763", "gene_name": "Csnk1g3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q62763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62763" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q62763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62763" } ] } ] }, { "uniprot_ac": "Q62829", "gene_name": "Pak3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q62829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62829" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q62829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62829" } ] } ] }, { "uniprot_ac": "Q62862", "gene_name": "Map2k5", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q62862", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62862" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q62862", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62862" } ] } ] }, { "uniprot_ac": "Q62868", "gene_name": "Rock2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q62868", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62868" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q62868", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62868" } ] } ] }, { "uniprot_ac": "Q62915", "gene_name": "Cask", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q62915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62915" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q62915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62915" } ] } ] }, { "uniprot_ac": "Q62925", "gene_name": "Map3k1", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q62925", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62925" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "Q62925", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62925" } ] } ] }, { "uniprot_ac": "Q63117", "gene_name": "Clk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63117" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q63117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63117" } ] } ] }, { "uniprot_ac": "Q63184", "gene_name": "Eif2ak2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63184" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63184" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q63184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63184" } ] } ] }, { "uniprot_ac": "Q63185", "gene_name": "Eif2ak1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63185", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63185" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q63185", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63185" } ] } ] }, { "uniprot_ac": "Q63285", "gene_name": "Uhmk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63285" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q63285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63285" } ] } ] }, { "uniprot_ac": "Q63433", "gene_name": "Pkn1", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63433", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63433" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q63433", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63433" } ] } ] }, { "uniprot_ac": "Q63450", "gene_name": "Camk1", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63450", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63450" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q63450", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63450" } ] } ] }, { "uniprot_ac": "Q63454", "gene_name": "Mapk4", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63454" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q63454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63454" } ] } ] }, { "uniprot_ac": "Q63470", "gene_name": "Dyrk1a", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q63470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63470" } ] }, { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63470" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q63470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63470" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q63470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63470" } ] } ] }, { "uniprot_ac": "Q63484", "gene_name": "Akt3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63484" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q63484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63484" } ] } ] }, { "uniprot_ac": "Q63531", "gene_name": "Rps6ka1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63531", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63531" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q63531", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63531" } ] } ] }, { "uniprot_ac": "Q63538", "gene_name": "Mapk12", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63538", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63538" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q63538", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63538" } ] } ] }, { "uniprot_ac": "Q63553", "gene_name": "Snrk", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63553", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63553" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q63553", "database": "UniProtKB", "url": 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[ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63638", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63638" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q63638", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63638" } ] } ] }, { "uniprot_ac": "Q63644", "gene_name": "Rock1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63644" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q63644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63644" } ] } ] }, { "uniprot_ac": "Q63686", "gene_name": "Cdk16", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63686", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63686" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q63686", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63686" } ] } ] }, { "uniprot_ac": "Q63699", "gene_name": "Cdk2", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63699", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63699" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q63699", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63699" } ] } ] }, { "uniprot_ac": "Q63796", "gene_name": "Map3k12", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63796", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63796" } ] 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"https://www.uniprot.org/uniprot/Q63932" } ] } ] }, { "uniprot_ac": "Q63945", "gene_name": "Set", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63945", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63945" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q63945", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63945" } ] } ] }, { "uniprot_ac": "Q641K5", "gene_name": "Nuak1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q641K5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q641K5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q641K5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q641K5" } ] } ] }, { "uniprot_ac": "Q641Z4", "gene_name": "Cdk9", "activity": [ { 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"UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64261" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q64261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64261" } ] } ] }, { "uniprot_ac": "Q64303", "gene_name": "Pak2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q64303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64303" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q64303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64303" } ] } ] }, { "uniprot_ac": "Q64595", "gene_name": "Prkg2", "activity": [ { "ec_number": "2.7.11.12", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q64595", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64595" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "Q64595", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64595" } ] } ] }, { "uniprot_ac": "Q64617", "gene_name": "Prkch", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q64617", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64617" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q64617", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64617" } ] } ] }, { "uniprot_ac": "Q64702", "gene_name": "Plk4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q64702", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64702" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q64702", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64702" } ] }, { "ec_number": "2.7.11.21", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q64702", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64702" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q64702", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64702" } ] } ] }, { "uniprot_ac": "Q66H84", "gene_name": "Mapkapk3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q66H84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66H84" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q66H84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66H84" } ] } ] }, { "uniprot_ac": "Q66HA1", "gene_name": "Map3k11", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + 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"https://www.uniprot.org/uniprot/Q66HE7" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q66HE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66HE7" } ] } ] }, { "uniprot_ac": "Q66L42", "gene_name": "Map3k10", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q66L42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66L42" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "Q66L42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66L42" } ] } ] }, { "uniprot_ac": "Q69Z98", "gene_name": "Brsk2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q69Z98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69Z98" } ] }, { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "Q69Z98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69Z98" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "Q69Z98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69Z98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q69Z98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69Z98" } ] } ] }, { "uniprot_ac": "Q69ZA1", "gene_name": "Cdk13", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q69ZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69ZA1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q69ZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69ZA1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q69ZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69ZA1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q69ZA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69ZA1" } ] } ] }, { "uniprot_ac": "Q69ZM6", "gene_name": "Stk36", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q69ZM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69ZM6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q69ZM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69ZM6" } ] } ] }, { "uniprot_ac": "Q6A1A2", "gene_name": "PDPK2P", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { 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"2.7.11.1", "activity": "", "evidence": [ { "id": "Q6DT37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6DT37" } ] } ] }, { "uniprot_ac": "Q6IQ55", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q6IQ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6IQ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6IQ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6IQ55" } ] } ] }, { "uniprot_ac": "Q6P0Q8", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q6P0Q8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P0Q8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6P0Q8", "database": "UniProtKB", "url": 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{ "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q6VAB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6VAB6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6VAB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6VAB6" } ] } ] }, { "uniprot_ac": "Q6XHA5", "gene_name": "roco11", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q6XHA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XHA5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6XHA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XHA5" } ] } ] }, { "uniprot_ac": "Q6XHA7", "gene_name": "roco9", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q6XHA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XHA7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6XHA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XHA7" } ] } ] }, { "uniprot_ac": "Q6XHB2", "gene_name": "roco4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q6XHB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XHB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6XHB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XHB2" } ] } ] }, { "uniprot_ac": "Q6XUX1", "gene_name": "Dstyk", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q6XUX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XUX1" } ] }, { 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"https://www.uniprot.org/uniprot/Q6XUX3" } ] } ] }, { "uniprot_ac": "Q6ZMQ8", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q6ZMQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZMQ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6ZMQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZMQ8" } ] } ] }, { "uniprot_ac": "Q6ZN16", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q6ZN16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZN16" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "Q6ZN16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZN16" } ] } ] }, { "uniprot_ac": "Q6ZQ29", "gene_name": "Taok2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q6ZQ29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZQ29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6ZQ29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZQ29" } ] } ] }, { "uniprot_ac": "Q6ZWH5", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q6ZWH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZWH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6ZWH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZWH5" } ] } ] }, { "uniprot_ac": "Q70PP2", "gene_name": "nonC", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q70PP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q70PP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q70PP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q70PP2" } ] } ] }, { "uniprot_ac": "Q71U36", "gene_name": "TUBA1A", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q71U36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q71U36" } ] } ] }, { "uniprot_ac": "Q75JK0", "gene_name": "zakA", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q75JK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q75JK0" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q75JK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q75JK0" } ] } ] }, { "uniprot_ac": "Q75JN1", "gene_name": "ifkC", "activity": [ { 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"Q76NV1", "gene_name": "dyrk1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q76NV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q76NV1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q76NV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q76NV1" } ] } ] }, { "uniprot_ac": "Q76P07", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q76P07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q76P07" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q76P07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q76P07" } ] } ] }, { "uniprot_ac": "Q7KRY6", "gene_name": "ball", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q7KRY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KRY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7KRY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KRY6" } ] } ] }, { "uniprot_ac": "Q7KZI7", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q7KZI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KZI7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7KZI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KZI7" } ] }, { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "Q7KZI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KZI7" } ] }, { "ec_number": 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"https://www.uniprot.org/uniprot/Q7TSJ6" } ] } ] }, { "uniprot_ac": "Q7TT49", "gene_name": "Cdc42bpb", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q7TT49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TT49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7TT49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TT49" } ] } ] }, { "uniprot_ac": "Q7TT50", "gene_name": "Cdc42bpb", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q7TT50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TT50" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7TT50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TT50" } ] } ] }, { "uniprot_ac": "Q7Z2Y5", "gene_name": "NRK", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q7Z2Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z2Y5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7Z2Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z2Y5" } ] } ] }, { "uniprot_ac": "Q80TR8", "gene_name": "Dcaf1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q80TR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80TR8" } ] } ] }, { "uniprot_ac": "Q80UE6", "gene_name": "Wnk4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q80UE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80UE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q80UE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80UE6" } ] } ] }, { "uniprot_ac": "Q80UV9", "gene_name": "Taf1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q80UV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80UV9" } ] }, { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q80UV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80UV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q80UV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80UV9" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q80UV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80UV9" } ] } ] }, { "uniprot_ac": "Q80UW5", "gene_name": "Cdc42bpg", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q80UW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80UW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q80UW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80UW5" } ] } ] }, { "uniprot_ac": "Q80X41", "gene_name": "Vrk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q80X41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80X41" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q80X41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80X41" } ] } ] }, { "uniprot_ac": "Q80XI6", "gene_name": "Map3k11", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q80XI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80XI6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "Q80XI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80XI6" } ] } ] }, { "uniprot_ac": "Q80XP9", "gene_name": "Wnk3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q80XP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80XP9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q80XP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80XP9" } ] } ] }, { "uniprot_ac": "Q80Y86", "gene_name": "Mapk15", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q80Y86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80Y86" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q80Y86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80Y86" } ] } ] }, { "uniprot_ac": "Q80YE4", "gene_name": "Aatk", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q80YE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80YE4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q80YE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80YE4" } ] } ] }, { "uniprot_ac": "Q80YE7", "gene_name": "Dapk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q80YE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80YE7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q80YE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80YE7" } ] } ] }, { "uniprot_ac": "Q80YP0", "gene_name": "Cdk3", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q80YP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80YP0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q80YP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80YP0" } ] } ] }, { "uniprot_ac": "Q80ZW0", "gene_name": "Stk35", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q80ZW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80ZW0" } ] } ] }, { "uniprot_ac": "Q810W7", "gene_name": "Mast1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q810W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810W7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q810W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810W7" } ] } ] }, { "uniprot_ac": "Q811L6", "gene_name": "Mast4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q811L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q811L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q811L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q811L6" } ] } ] }, { "uniprot_ac": "Q869L4", "gene_name": "fnkA", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q869L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q869L4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q869L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q869L4" } ] } ] }, { "uniprot_ac": "Q869N2", "gene_name": "pakB", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q869N2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q869N2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q869N2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q869N2" } ] } ] }, { "uniprot_ac": "Q869T7", "gene_name": "pakF", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q869T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q869T7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q869T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q869T7" } ] } ] }, { "uniprot_ac": "Q869X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q869X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q869X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q869X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q869X3" } ] } ] }, { "uniprot_ac": "Q86A12", "gene_name": "sky1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q86A12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86A12" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q86A12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86A12" } ] } ] }, { "uniprot_ac": "Q86AE1", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q86AE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86AE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q86AE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86AE1" } ] } ] }, { "uniprot_ac": "Q86AT8", "gene_name": "spkA-1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q86AT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86AT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q86AT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86AT8" } ] } ] }, { "uniprot_ac": "Q86C65", "gene_name": "tor", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q86C65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86C65" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q86C65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86C65" } ] } ] }, { "uniprot_ac": "Q86CS2", "gene_name": "atg1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q86CS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86CS2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q86CS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86CS2" } ] } ] }, { "uniprot_ac": "Q86HG9", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q86HG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86HG9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q86HG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86HG9" } ] } ] }, { "uniprot_ac": "Q86HN7", "gene_name": "PLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q86HN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86HN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q86HN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86HN7" } ] } ] }, { "uniprot_ac": "Q86HW6", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q86HW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86HW6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q86HW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86HW6" } ] } ] }, { "uniprot_ac": "Q86I06", "gene_name": "nek3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q86I06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86I06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q86I06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86I06" } ] } ] }, { "uniprot_ac": "Q86IX1", "gene_name": "dst1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q86IX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86IX1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q86IX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86IX1" } ] } ] }, { "uniprot_ac": "Q86SG6", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q86SG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86SG6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q86SG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86SG6" } ] } ] }, { "uniprot_ac": "Q86TB3", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q86TB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86TB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q86TB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86TB3" } ] } ] }, { "uniprot_ac": "Q86UE8", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q86UE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86UE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q86UE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86UE8" } ] } ] }, { "uniprot_ac": "Q86UX6", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q86UX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86UX6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q86UX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86UX6" } ] } ] }, { "uniprot_ac": "Q86V86", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q86V86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86V86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q86V86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86V86" } ] } ] }, { "uniprot_ac": "Q86Y07", "gene_name": "VRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q86Y07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86Y07" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q86Y07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86Y07" } ] } ] }, { "uniprot_ac": "Q86YV6", "gene_name": "MYLK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q86YV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86YV6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q86YV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86YV6" } ] } ] }, { "uniprot_ac": "Q86Z02", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q86Z02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86Z02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q86Z02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86Z02" } ] } ] }, { "uniprot_ac": "Q8BG48", "gene_name": "Stk17b", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8BG48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BG48" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8BG48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BG48" } ] } ] }, { "uniprot_ac": "Q8BGW6", "gene_name": "Stk32a", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8BGW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BGW6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8BGW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BGW6" } ] } ] }, { "uniprot_ac": "Q8BHI9", "gene_name": "Nim1k", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8BHI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BHI9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8BHI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BHI9" } ] } ] }, { "uniprot_ac": "Q8BI55", "gene_name": "Dyrk4", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8BI55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BI55" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q8BI55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BI55" } ] } ] }, { "uniprot_ac": "Q8BK63", "gene_name": "Csnk1a1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8BK63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BK63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8BK63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BK63" } ] } ] }, { "uniprot_ac": "Q8BKX6", "gene_name": "Smg1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8BKX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BKX6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8BKX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BKX6" } ] } ] }, { "uniprot_ac": "Q8BLF2", "gene_name": "Cdkl3", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8BLF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BLF2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q8BLF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BLF2" } ] } ] }, { "uniprot_ac": "Q8BLK9", "gene_name": "Rps6kc1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8BLK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BLK9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8BLK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BLK9" } ] } ] }, { "uniprot_ac": "Q8BN21", "gene_name": "Vrk2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8BN21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BN21" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8BN21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BN21" } ] } ] }, { "uniprot_ac": "Q8BPM2", "gene_name": "Map4k5", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8BPM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BPM2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8BPM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BPM2" } ] } ] }, { "uniprot_ac": "Q8BRK8", "gene_name": "Prkaa2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8BRK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BRK8" } ] }, { "ec_number": "2.7.11.31", "activity": "ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase].", "evidence": [ { "id": "Q8BRK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BRK8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8BRK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BRK8" } ] } ] }, { "uniprot_ac": "Q8BSK8", "gene_name": "Rps6kb1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8BSK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BSK8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8BSK8", 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1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "Q8BTI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BTI9" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "Q8BTI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BTI9" } ] } ] }, { "uniprot_ac": "Q8BTW9", "gene_name": "Pak4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8BTW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BTW9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8BTW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BTW9" } ] } ] }, { "uniprot_ac": "Q8BVP5", "gene_name": "Csnk1g2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": 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"2.7.11.22", "activity": "", "evidence": [ { "id": "Q8BWD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWD8" } ] } ] }, { "uniprot_ac": "Q8BWE1", "gene_name": "1810024B03Rik", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8BWE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8BWE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWE1" } ] } ] }, { "uniprot_ac": "Q8BWQ5", "gene_name": "Dclk3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8BWQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8BWQ5", "database": "UniProtKB", "url": 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{ "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8BYR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BYR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8BYR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BYR2" } ] } ] }, { "uniprot_ac": "Q8BZ03", "gene_name": "Prkd2", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8BZ03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BZ03" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q8BZ03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BZ03" } ] } ] }, { "uniprot_ac": "Q8BZ25", "gene_name": "Ankk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", 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"Q8MVR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8MVR1" } ] } ] }, { "uniprot_ac": "Q8MYF1", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8MYF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8MYF1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8MYF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8MYF1" } ] } ] }, { "uniprot_ac": "Q8N165", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8N165", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N165" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8N165", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N165" } ] } ] }, { "uniprot_ac": "Q8N2I9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8N2I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N2I9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8N2I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N2I9" } ] } ] }, { "uniprot_ac": "Q8N4C8", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8N4C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N4C8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8N4C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N4C8" } ] } ] }, { "uniprot_ac": "Q8N568", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8N568", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N568" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8N568", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N568" } ] } ] }, { "uniprot_ac": "Q8N5S9", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8N5S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N5S9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q8N5S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N5S9" } ] } ] }, { "uniprot_ac": "Q8N752", "gene_name": "CSNK1A1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8N752", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N752" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8N752", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N752" } ] } ] }, { "uniprot_ac": "Q8NE63", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8NE63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NE63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8NE63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NE63" } ] } ] }, { "uniprot_ac": "Q8NEV1", "gene_name": "CSNK2A3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8NEV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NEV1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8NEV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NEV1" } ] } ] }, { "uniprot_ac": "Q8NEV4", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8NEV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NEV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8NEV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NEV4" } ] } ] }, { "uniprot_ac": "Q8NFD2", "gene_name": "ANKK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8NFD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NFD2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8NFD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NFD2" } ] } ] }, { "uniprot_ac": "Q8NG66", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8NG66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NG66" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8NG66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NG66" } ] } ] }, { "uniprot_ac": "Q8QZR7", "gene_name": "Pdik1l", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8QZR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8QZR7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8QZR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8QZR7" } ] } ] }, { "uniprot_ac": "Q8QZV4", "gene_name": "Stk32c", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8QZV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8QZV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8QZV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8QZV4" } ] } ] }, { "uniprot_ac": "Q8QZX0", "gene_name": "Sbk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8QZX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8QZX0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8QZX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8QZX0" } ] } ] }, { "uniprot_ac": "Q8R2S1", "gene_name": "Rps6kl1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8R2S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R2S1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8R2S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R2S1" } ] } ] }, { "uniprot_ac": "Q8R3L8", "gene_name": "Cdk8", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8R3L8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R3L8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q8R3L8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R3L8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q8R3L8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R3L8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q8R3L8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R3L8" } ] } ] }, { "uniprot_ac": "Q8R4K2", "gene_name": "Irak4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8R4K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R4K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8R4K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R4K2" } ] } ] }, { "uniprot_ac": "Q8R4U9", "gene_name": "Sgk2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8R4U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R4U9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8R4U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R4U9" } ] } ] }, { "uniprot_ac": "Q8R4V0", "gene_name": "Sgk3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8R4V0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R4V0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8R4V0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R4V0" } ] } ] }, { "uniprot_ac": "Q8SSS9", "gene_name": "qkgA-2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8SSS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8SSS9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8SSS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8SSS9" } ] } ] }, { "uniprot_ac": "Q8SSV3", "gene_name": "mkcD", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8SSV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8SSV3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8SSV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8SSV3" } ] } ] }, { "uniprot_ac": "Q8SSY6", "gene_name": "", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8SSY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8SSY6" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8SSY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8SSY6" } ] } ] }, { "uniprot_ac": "Q8T0S6", "gene_name": "hpo", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8T0S6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T0S6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8T0S6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T0S6" } ] } ] }, { "uniprot_ac": "Q8T2I8", "gene_name": "sepA", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8T2I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T2I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8T2I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T2I8" } ] } ] }, { "uniprot_ac": "Q8T9L5", "gene_name": "Lkb1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8T9L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T9L5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8T9L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T9L5" } ] } ] }, { "uniprot_ac": "Q8TAS1", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8TAS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TAS1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8TAS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TAS1" } ] } ] }, { "uniprot_ac": "Q8TD08", "gene_name": "MAPK15", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8TD08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TD08" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q8TD08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TD08" } ] } ] }, { "uniprot_ac": "Q8TD19", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8TD19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TD19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8TD19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TD19" } ] } ] }, { "uniprot_ac": "Q8TDC3", "gene_name": "BRSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8TDC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TDC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8TDC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TDC3" } ] }, { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "Q8TDC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TDC3" } ] } ] }, { "uniprot_ac": "Q8TDR2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8TDR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TDR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8TDR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TDR2" } ] } ] }, { "uniprot_ac": "Q8TDX7", "gene_name": "NEK7", "activity": [ { "ec_number": "2.7.11.34", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8TDX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TDX7" } ] }, { "ec_number": "2.7.11.34", "activity": "", "evidence": [ { "id": "Q8TDX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TDX7" } ] } ] }, { "uniprot_ac": "Q8TF76", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8TF76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TF76" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8TF76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TF76" } ] } ] }, { "uniprot_ac": "Q8VBY2", "gene_name": "Camkk1", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8VBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VBY2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q8VBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VBY2" } ] } ] }, { "uniprot_ac": "Q8VCT9", "gene_name": "Tesk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8VCT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCT9" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q8VCT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCT9" } ] } ] }, { "uniprot_ac": "Q8VD65", "gene_name": "Pik3r4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8VD65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VD65" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8VD65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VD65" } ] } ] }, { "uniprot_ac": "Q8VDF3", "gene_name": "Dapk2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8VDF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDF3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8VDF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDF3" } ] } ] }, { "uniprot_ac": "Q8VDG6", "gene_name": "Map3k21", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8VDG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDG6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "Q8VDG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDG6" } ] } ] }, { "uniprot_ac": "Q8VDU5", "gene_name": "Snrk", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8VDU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDU5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8VDU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDU5" } ] } ] }, { "uniprot_ac": "Q8VHF0", "gene_name": "Mark3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8VHF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8VHF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHF0" } ] } ] }, { "uniprot_ac": "Q8VHJ5", "gene_name": "Mark1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8VHJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHJ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8VHJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHJ5" } ] }, { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "Q8VHJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHJ5" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "Q8VHJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHJ5" } ] } ] }, { "uniprot_ac": "Q8WU08", "gene_name": "STK32A", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8WU08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WU08" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8WU08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WU08" } ] } ] }, { "uniprot_ac": "Q8WXR4", "gene_name": "MYO3B", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8WXR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WXR4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8WXR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WXR4" } ] } ] }, { "uniprot_ac": "Q8WZ42", "gene_name": "TTN", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8WZ42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WZ42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q8WZ42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WZ42" } ] } ] }, { "uniprot_ac": "Q91VB2", "gene_name": "Camk1g", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q91VB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91VB2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q91VB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91VB2" } ] } ] }, { "uniprot_ac": "Q91VJ4", "gene_name": "Stk38", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q91VJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91VJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q91VJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91VJ4" } ] } ] }, { "uniprot_ac": "Q91XS8", "gene_name": "Stk17b", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q91XS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91XS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q91XS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91XS8" } ] } ] }, { "uniprot_ac": "Q91Y86", "gene_name": "Mapk8", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q91Y86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91Y86" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q91Y86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91Y86" } ] } ] }, { "uniprot_ac": "Q91YA2", "gene_name": "Pskh1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q91YA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91YA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q91YA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91YA2" } ] } ] }, { "uniprot_ac": "Q91YS8", "gene_name": "Camk1", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q91YS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91YS8" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q91YS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91YS8" } ] } ] }, { "uniprot_ac": "Q91Z96", "gene_name": "Bmp2k", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q91Z96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91Z96" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q91Z96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91Z96" } ] } ] }, { "uniprot_ac": "Q91ZB0", "gene_name": "Alpk2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q91ZB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZB0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q91ZB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZB0" } ] } ] }, { "uniprot_ac": "Q91ZN7", "gene_name": "Chek1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q91ZN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q91ZN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZN7" } ] }, { "ec_number": "2.4.99.18", "activity": "a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = a dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein].", "evidence": [ { "id": "Q91ZN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZN7" } ] }, { "ec_number": "2.4.99.18", "activity": "", "evidence": [ { "id": "Q91ZN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZN7" } ] } ] }, { "uniprot_ac": "Q91ZR4", "gene_name": "Nek8", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q91ZR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZR4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q91ZR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZR4" } ] } ] }, { "uniprot_ac": "Q922Q2", "gene_name": "Riok1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q922Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922Q2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q922Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922Q2" } ] }, { "ec_number": "3.6.3.-", "activity": "", "evidence": [ { "id": "Q922Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922Q2" } ] } ] }, { "uniprot_ac": "Q922R0", "gene_name": "Prkx", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q922R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922R0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q922R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922R0" } ] } ] }, { "uniprot_ac": "Q922Y0", "gene_name": "Dyrk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q922Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922Y0" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q922Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922Y0" } ] } ] }, { "uniprot_ac": "Q923J1", "gene_name": "Trpm7", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q923J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q923J1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q923J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q923J1" } ] } ] }, { "uniprot_ac": "Q923T9", "gene_name": "Camk2g", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q923T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q923T9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q923T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q923T9" } ] } ] }, { "uniprot_ac": "Q924C5", "gene_name": "Alpk3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q924C5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q924C5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q924C5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q924C5" } ] } ] }, { "uniprot_ac": "Q924I2", "gene_name": "Map4k3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q924I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q924I2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q924I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q924I2" } ] } ] }, { "uniprot_ac": "Q924U5", "gene_name": "Tesk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q924U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q924U5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q924U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q924U5" } ] } ] }, { "uniprot_ac": "Q924X7", "gene_name": "Stk33", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q924X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q924X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q924X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q924X7" } ] } ] }, { "uniprot_ac": "Q92539", "gene_name": "LPIN2", "activity": [ { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "Q92539", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92539" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "Q92539", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92539" } ] } ] }, { "uniprot_ac": "Q925B3", "gene_name": "Trpm7", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q925B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q925B3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q925B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q925B3" } ] } ] }, { "uniprot_ac": "Q925D6", "gene_name": "Map2k6", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q925D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q925D6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q925D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q925D6" } ] } ] }, { "uniprot_ac": "Q925K9", "gene_name": "Tssk6", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q925K9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q925K9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q925K9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q925K9" } ] } ] }, { "uniprot_ac": "Q92630", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q92630", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92630" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q92630", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92630" } ] } ] }, { "uniprot_ac": "Q92772", "gene_name": "CDKL2", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q92772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92772" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q92772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92772" } ] } ] }, { "uniprot_ac": "Q92918", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q92918", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92918" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q92918", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92918" } ] } ] }, { "uniprot_ac": "Q94533", "gene_name": "S6k", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q94533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q94533" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q94533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q94533" } ] } ] }, { "uniprot_ac": "Q95SH0", "gene_name": "Pask", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q95SH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q95SH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": 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"Q95YH0", "gene_name": "cdk8", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q95YH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q95YH0" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q95YH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q95YH0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q95YH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q95YH0" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q95YH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q95YH0" } ] } ] }, { "uniprot_ac": "Q96BR1", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q96BR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96BR1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q96BR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96BR1" } ] } ] }, { "uniprot_ac": "Q96C45", "gene_name": "ULK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q96C45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96C45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q96C45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96C45" } ] } ] }, { "uniprot_ac": "Q96GD4", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q96GD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96GD4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q96GD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96GD4" } ] } ] }, { "uniprot_ac": "Q96GX5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q96GX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96GX5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q96GX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96GX5" } ] } ] }, { "uniprot_ac": "Q96J92", "gene_name": "WNK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q96J92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96J92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q96J92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96J92" } ] } ] }, { "uniprot_ac": "Q96JH7", "gene_name": "VCPIP1", "activity": [ { "ec_number": "3.4.19.12", "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "Q96JH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96JH7" } ] }, { "ec_number": "3.4.19.12", "activity": "", "evidence": [ { "id": "Q96JH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96JH7" } ] } ] }, { "uniprot_ac": "Q96KB5", "gene_name": "PBK", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q96KB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96KB5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q96KB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96KB5" } ] } ] }, { "uniprot_ac": "Q96L34", "gene_name": "MARK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q96L34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96L34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q96L34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96L34" } ] } ] }, { "uniprot_ac": "Q96L96", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q96L96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96L96" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q96L96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96L96" } ] } ] }, { "uniprot_ac": "Q96LW2", "gene_name": "RSKR", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q96LW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96LW2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q96LW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96LW2" } ] } ] }, { "uniprot_ac": "Q96NX5", "gene_name": "CAMK1G", "activity": [ { "ec_number": "2.7.11.17", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q96NX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96NX5" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q96NX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96NX5" } ] } ] }, { "uniprot_ac": "Q96PF2", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) 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"Q96QS6", "gene_name": "PSKH2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q96QS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96QS6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q96QS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96QS6" } ] } ] }, { "uniprot_ac": "Q96QT4", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q96QT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96QT4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q96QT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96QT4" } ] } ] }, { "uniprot_ac": "Q96RG2", "gene_name": "PASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP 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"activity": "", "evidence": [ { "id": "Q99436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99436" } ] } ] }, { "uniprot_ac": "Q99558", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q99558", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99558" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "Q99558", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99558" } ] } ] }, { "uniprot_ac": "Q99570", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q99570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99570" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q99570", "database": "UniProtKB", "url": 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"activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q99759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99759" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "Q99759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99759" } ] } ] }, { "uniprot_ac": "Q99986", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q99986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99986" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q99986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99986" } ] } ] }, { "uniprot_ac": "Q99J82", "gene_name": "Ilk", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + 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"ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q99J95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99J95" } ] } ] }, { "uniprot_ac": "Q99JP0", "gene_name": "Map4k3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q99JP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99JP0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q99JP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99JP0" } ] } ] }, { "uniprot_ac": "Q99JT2", "gene_name": "Stk26", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q99JT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99JT2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q99JT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99JT2" } ] } ] }, { "uniprot_ac": "Q99KH8", "gene_name": "Stk24", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q99KH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99KH8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q99KH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99KH8" } ] } ] }, { "uniprot_ac": "Q99KY4", "gene_name": "Gak", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q99KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99KY4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q99KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99KY4" } ] } ] }, { "uniprot_ac": "Q99MQ3", "gene_name": "Pink1", "activity": [ { 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"evidence": [ { "id": "Q99N57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99N57" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q99N57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99N57" } ] } ] }, { "uniprot_ac": "Q99PW4", "gene_name": "Tp53rkb", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q99PW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99PW4" } ] }, { "ec_number": "3.6.-.-", "activity": "", "evidence": [ { "id": "Q99PW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99PW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q99PW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99PW4" } ] } ] }, { "uniprot_ac": "Q9BQE3", "gene_name": "TUBA1C", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q9BQE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BQE3" } ] } ] }, { "uniprot_ac": "Q9BQI3", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9BQI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BQI3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9BQI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BQI3" } ] } ] }, { "uniprot_ac": "Q9BQK8", "gene_name": "LPIN3", "activity": [ { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "Q9BQK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BQK8" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "Q9BQK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BQK8" } ] } ] 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"https://www.uniprot.org/uniprot/Q9BUB5" } ] } ] }, { "uniprot_ac": "Q9BVS4", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9BVS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BVS4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9BVS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BVS4" } ] } ] }, { "uniprot_ac": "Q9BWU1", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9BWU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BWU1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q9BWU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BWU1" } ] } ] }, { "uniprot_ac": "Q9BX84", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9BX84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BX84" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9BX84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BX84" } ] } ] }, { "uniprot_ac": "Q9BXA6", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9BXA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BXA6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9BXA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BXA6" } ] } ] }, { "uniprot_ac": "Q9BXA7", "gene_name": "TSSK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9BXA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BXA7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9BXA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BXA7" } ] } ] }, { "uniprot_ac": "Q9BXM7", "gene_name": "PINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9BXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BXM7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9BXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BXM7" } ] } ] }, { "uniprot_ac": "Q9BXU1", "gene_name": "STK31", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9BXU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BXU1" } ] }, { 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[ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9CQS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CQS5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9CQS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CQS5" } ] } ] }, { "uniprot_ac": "Q9CXB8", "gene_name": "Alpk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9CXB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CXB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9CXB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CXB8" } ] } ] }, { "uniprot_ac": "Q9D2E1", "gene_name": "Tssk3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9D2E1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D2E1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9D2E1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D2E1" } ] } ] }, { "uniprot_ac": "Q9D411", "gene_name": "Tssk4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9D411", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D411" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9D411", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D411" } ] } ] }, { "uniprot_ac": "Q9DBU3", "gene_name": "Riok3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9DBU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBU3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9DBU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBU3" } ] } ] }, { "uniprot_ac": "Q9DC28", "gene_name": "Csnk1d", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9DC28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DC28" } ] }, { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "Q9DC28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DC28" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9DC28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DC28" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "Q9DC28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DC28" } ] } ] }, { "uniprot_ac": "Q9EQY0", "gene_name": "Ern1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9EQY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EQY0" } ] }, { "ec_number": "3.1.26.-", "activity": "", "evidence": [ { "id": "Q9EQY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EQY0" } ] } ] }, { "uniprot_ac": "Q9ERE3", "gene_name": "Sgk3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9ERE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ERE3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9ERE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ERE3" } ] } ] }, { "uniprot_ac": "Q9ERH7", "gene_name": "Hipk3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9ERH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ERH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9ERH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ERH7" } ] } ] }, { "uniprot_ac": "Q9ERK0", "gene_name": "Ripk4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9ERK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ERK0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9ERK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ERK0" } ] } ] }, { "uniprot_ac": "Q9ES70", "gene_name": "Nek6", "activity": [ { "ec_number": "2.7.11.34", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9ES70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ES70" } ] }, { "ec_number": "2.7.11.34", "activity": "", "evidence": [ { "id": "Q9ES70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ES70" } ] } ] }, { "uniprot_ac": "Q9ES74", "gene_name": "Nek7", "activity": [ { "ec_number": "2.7.11.34", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9ES74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ES74" } ] }, { "ec_number": "2.7.11.34", "activity": "", "evidence": [ { "id": "Q9ES74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ES74" } ] } ] }, { "uniprot_ac": "Q9ESG9", "gene_name": "Pkmyt1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9ESG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ESG9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9ESG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ESG9" } ] } ] }, { "uniprot_ac": "Q9ESL4", "gene_name": "Map3k20", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9ESL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ESL4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "Q9ESL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ESL4" } ] } ] }, { "uniprot_ac": "Q9H093", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9H093", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H093" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9H093", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H093" } ] } ] }, { "uniprot_ac": "Q9H0K1", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9H0K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H0K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9H0K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H0K1" } ] } ] }, { "uniprot_ac": "Q9H0U4", "gene_name": "RAB1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "Q9H0U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H0U4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q9H0U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H0U4" } ] } ] }, { "uniprot_ac": "Q9H2G2", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9H2G2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H2G2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9H2G2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H2G2" } ] } ] }, { "uniprot_ac": "Q9H2K8", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9H2K8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H2K8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9H2K8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H2K8" } ] } ] }, { "uniprot_ac": "Q9H2X6", "gene_name": "HIPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9H2X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H2X6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9H2X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H2X6" } ] } ] }, { "uniprot_ac": "Q9H422", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9H422", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H422" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9H422", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H422" } ] } ] }, { "uniprot_ac": "Q9H4A3", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9H4A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H4A3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9H4A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H4A3" } ] } ] }, { "uniprot_ac": "Q9H4B4", "gene_name": "PLK3", "activity": [ { "ec_number": "2.7.11.21", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9H4B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H4B4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q9H4B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H4B4" } ] } ] }, { "uniprot_ac": "Q9H853", "gene_name": "TUBA4B", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q9H853", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H853" } ] } ] }, { "uniprot_ac": "Q9HAZ1", "gene_name": "CLK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9HAZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HAZ1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q9HAZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HAZ1" } ] } ] }, { "uniprot_ac": "Q9HBH9", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9HBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HBH9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9HBH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HBH9" } ] } ] }, { "uniprot_ac": "Q9HBY8", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9HBY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HBY8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9HBY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HBY8" } ] } ] }, { "uniprot_ac": "Q9HC98", "gene_name": "NEK6", "activity": [ { "ec_number": "2.7.11.34", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9HC98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HC98" } ] }, { "ec_number": "2.7.11.34", "activity": "", "evidence": [ { "id": "Q9HC98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HC98" } ] } ] }, { "uniprot_ac": "Q9HCP0", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9HCP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCP0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9HCP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCP0" } ] } ] }, { "uniprot_ac": "Q9JHG7", "gene_name": "Pik3cg", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9JHG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JHG7" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "Q9JHG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JHG7" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "Q9JHG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JHG7" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "Q9JHG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JHG7" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "Q9JHG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JHG7" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "Q9JHG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JHG7" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "Q9JHG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JHG7" } ] } ] }, { "uniprot_ac": "Q9JHU3", "gene_name": "Cdk20", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9JHU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JHU3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q9JHU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JHU3" } ] } ] }, { "uniprot_ac": "Q9JI10", "gene_name": "Stk3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9JI10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JI10" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9JI10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JI10" } ] } ] }, { "uniprot_ac": "Q9JI11", "gene_name": "Stk4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9JI11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JI11" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9JI11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JI11" } ] } ] }, { "uniprot_ac": "Q9JIH7", "gene_name": "Wnk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9JIH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JIH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9JIH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JIH7" } ] } ] }, { "uniprot_ac": "Q9JIX9", "gene_name": "Fastk", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9JIX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JIX9" } ] }, { "ec_number": "2.7.11.8", "activity": "ATP + L-threonyl-[Fas-activated protein] = ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein].", "evidence": [ { "id": "Q9JIX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JIX9" } ] }, { "ec_number": 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L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VA38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VA38" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VA38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VA38" } ] } ] }, { "uniprot_ac": "Q9VBU2", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VBU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VBU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VBU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VBU2" } ] } ] }, { "uniprot_ac": "Q9VCV0", "gene_name": "Takl2", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VCV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VCV0" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "Q9VCV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VCV0" } ] } ] }, { "uniprot_ac": "Q9VD82", "gene_name": "Dmel\\CG6800", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VD82" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q9VD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VD82" } ] } ] }, { "uniprot_ac": "Q9VE06", "gene_name": "cdi", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VE06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VE06" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q9VE06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VE06" } ] } ] }, { "uniprot_ac": "Q9VEN3", "gene_name": "GckIII", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VEN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VEN3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VEN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VEN3" } ] } ] }, { "uniprot_ac": "Q9VGF9", "gene_name": "aurA", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VGF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VGF9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VGF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VGF9" } ] } ] }, { "uniprot_ac": "Q9VI13", "gene_name": "Pak", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VI13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VI13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VI13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VI13" } ] } ] }, { "uniprot_ac": "Q9VI84", "gene_name": "Dmel\\CG1227", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VI84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VI84" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VI84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VI84" } ] } ] }, { "uniprot_ac": "Q9VJ30", "gene_name": "Nak", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VJ30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJ30" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VJ30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJ30" } ] } ] }, { "uniprot_ac": "Q9VJC2", "gene_name": "Dmel\\CG7094", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VJC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VJC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJC2" } ] } ] }, { "uniprot_ac": "Q9VK45", "gene_name": "mTor", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VK45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VK45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VK45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VK45" } ] } ] }, { "uniprot_ac": "Q9VKN7", "gene_name": "aurB", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VKN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VKN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VKN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VKN7" } ] } ] }, { "uniprot_ac": "Q9VL34", "gene_name": "Dmel\\CG4839", "activity": [ { "ec_number": "2.7.11.12", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VL34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VL34" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "Q9VL34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VL34" } ] } ] }, { "uniprot_ac": "Q9VM90", "gene_name": "meng", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VM90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VM90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VM90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VM90" } ] } ] }, { "uniprot_ac": "Q9VMY8", "gene_name": "aux", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VMY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VMY8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VMY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VMY8" } ] } ] }, { "uniprot_ac": "Q9VN23", "gene_name": "CG10532", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VN23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VN23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VN23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VN23" } ] } ] }, { "uniprot_ac": "Q9VP22", "gene_name": "Cdk12", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VP22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VP22" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q9VP22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VP22" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q9VP22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VP22" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q9VP22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VP22" } ] } ] }, { "uniprot_ac": "Q9VPC0", "gene_name": "Pitslre", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VPC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VPC0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q9VPC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VPC0" } ] } ] }, { "uniprot_ac": "Q9VR42", "gene_name": "Dmel\\CG3008", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VR42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VR42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VR42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VR42" } ] } ] }, { "uniprot_ac": "Q9VRJ6", "gene_name": "Tcs5", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VRJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VRJ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VRJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VRJ6" } ] } ] }, { "uniprot_ac": "Q9VT57", "gene_name": "Cdk8", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VT57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VT57" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q9VT57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VT57" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q9VT57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VT57" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q9VT57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VT57" } ] } ] }, { "uniprot_ac": "Q9VTL5", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VTL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VTL5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VTL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VTL5" } ] } ] }, { "uniprot_ac": "Q9VUQ9", "gene_name": "dop", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VUQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VUQ9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VUQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VUQ9" } ] } ] }, { "uniprot_ac": "Q9VUV4", "gene_name": "sff", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VUV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VUV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VUV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VUV4" } ] } ] }, { "uniprot_ac": "Q9VW24", "gene_name": "wnd", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VW24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VW24" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "Q9VW24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VW24" } ] } ] }, { "uniprot_ac": "Q9VXE3", "gene_name": "Rok", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VXE3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VXE3" } ] } ] }, { "uniprot_ac": "Q9VXE5", "gene_name": "mbt", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VXE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VXE5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VXE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VXE5" } ] } ] }, { "uniprot_ac": "Q9VXG8", "gene_name": "mei-41", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VXG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VXG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VXG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VXG8" } ] } ] }, { "uniprot_ac": "Q9VXN5", "gene_name": "Dmel\\CG8565", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VXN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VXN5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VXN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VXN5" } ] } ] }, { "uniprot_ac": "Q9VZI2", "gene_name": "Ack", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9VZI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VZI2" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VZI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VZI2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9VZI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VZI2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q9VZI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VZI2" } ] } ] }, { "uniprot_ac": "Q9W002", "gene_name": "msn", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9W002", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9W002" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9W002", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9W002" } ] } ] }, { "uniprot_ac": "Q9W0V1", "gene_name": "Pdk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9W0V1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9W0V1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9W0V1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9W0V1" } ] } ] }, { "uniprot_ac": "Q9W1B0", "gene_name": "gek", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9W1B0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9W1B0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9W1B0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9W1B0" } ] } ] }, { "uniprot_ac": "Q9W354", "gene_name": "Erk7", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9W354", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9W354" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q9W354", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9W354" } ] } ] }, { "uniprot_ac": "Q9W3N8", "gene_name": "Nek2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9W3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9W3N8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9W3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9W3N8" } ] } ] }, { "uniprot_ac": "Q9WTK7", "gene_name": "Stk11", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9WTK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WTK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9WTK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WTK7" } ] } ] }, { "uniprot_ac": "Q9WTQ0", "gene_name": "Prkcq", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9WTQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WTQ0" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q9WTQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WTQ0" } ] } ] }, { "uniprot_ac": "Q9WTQ1", "gene_name": "Prkd1", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9WTQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WTQ1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q9WTQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WTQ1" } ] } ] }, { "uniprot_ac": "Q9WTR2", "gene_name": "Map3k6", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9WTR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WTR2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "Q9WTR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WTR2" } ] } ] }, { "uniprot_ac": "Q9WTU6", "gene_name": "Mapk9", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9WTU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WTU6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q9WTU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WTU6" } ] } ] }, { "uniprot_ac": "Q9WTY9", "gene_name": "Mapk13", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9WTY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WTY9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q9WTY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WTY9" } ] } ] }, { "uniprot_ac": "Q9WUA6", "gene_name": "Akt3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + 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"https://www.uniprot.org/uniprot/Q9WUL6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "Q9WUL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WUL6" } ] } ] }, { "uniprot_ac": "Q9WUN2", "gene_name": "Tbk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9WUN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WUN2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9WUN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WUN2" } ] } ] }, { "uniprot_ac": "Q9WUT3", "gene_name": "Rps6ka2", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9WUT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WUT3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9WUT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WUT3" } ] } ] }, { "uniprot_ac": "Q9WV60", "gene_name": "Gsk3b", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9WV60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WV60" } ] }, { "ec_number": "2.7.11.26", "activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].", "evidence": [ { "id": "Q9WV60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WV60" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "Q9WV60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WV60" } ] } ] }, { "uniprot_ac": "Q9WVC6", "gene_name": "Sgk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9WVC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WVC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9WVC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WVC6" } ] } ] }, { "uniprot_ac": "Q9WVS4", "gene_name": "Mok", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9WVS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WVS4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q9WVS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WVS4" } ] } ] }, { "uniprot_ac": "Q9WVS7", "gene_name": "Map2k5", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9WVS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WVS7" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q9WVS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WVS7" } ] } ] }, { "uniprot_ac": "Q9WVS8", "gene_name": "Mapk7", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9WVS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WVS8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q9WVS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WVS8" } ] } ] }, { "uniprot_ac": "Q9Y243", "gene_name": "AKT3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9Y243", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y243" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9Y243", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y243" } ] } ] }, { 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L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9Y2I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y2I7" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "Q9Y2I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y2I7" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "Q9Y2I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y2I7" } ] } ] }, { "uniprot_ac": "Q9Y2K2", "gene_name": "SIK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9Y2K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y2K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": 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"Q9Y463", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9Y463", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y463" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q9Y463", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y463" } ] } ] }, { "uniprot_ac": "Q9Y4B6", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9Y4B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y4B6" } ] } ] }, { "uniprot_ac": "Q9Y4K4", "gene_name": "MAP4K5", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9Y4K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y4K4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9Y4K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y4K4" } ] } ] }, { "uniprot_ac": "Q9Y572", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9Y572", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y572" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9Y572", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y572" } ] } ] }, { "uniprot_ac": "Q9Y5B8", "gene_name": "NME7", "activity": [ { "ec_number": "2.7.4.6", "activity": "a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP.", "evidence": [ { "id": "Q9Y5B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y5B8" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "Q9Y5B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y5B8" } ] } ] }, { "uniprot_ac": "Q9Y5S2", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9Y5S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y5S2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9Y5S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y5S2" } ] } ] }, { "uniprot_ac": "Q9Y6E0", "gene_name": "STK24", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9Y6E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y6E0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9Y6E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y6E0" } ] } ] }, { "uniprot_ac": "Q9Y6M4", "gene_name": "CSNK1G3", 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