{ "uniprot_canonical_ac": "P05198-1", "uniprot_ac": "P05198", "uniprot_id": "IF2A_HUMAN", "mass": { "chemical_mass": 36112.0, "monoisotopic_mass": 36112.0 }, "refseq": { "ac": "NP_004085", "name": "eukaryotic translation initiation factor 2 subunit 1", "summary": "The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004085" }, "gene_names": [ { "name": "EIF2S1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P05198", "id": "P05198" }, { "name": "EIF-2; EIF-2A; EIF-2alpha; EIF2; EIF2A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004085", "id": "NP_004085" }, { "name": "EIF2A", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P05198", "id": "P05198" }, { "name": "EIF2S1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004085", "id": "NP_004085" } ], "protein_names": [ { "name": "Eukaryotic translation initiation factor 2 subunit 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P05198" }, { "name": "Eukaryotic translation initiation factor 2 subunit alpha", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P05198" }, { "name": "eIF-2-alpha; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa; eIF2-alpha", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004085", "id": "NP_004085" }, { "name": "eIF-2-alpha", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P05198" }, { "name": "eIF-2A", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P05198" }, { "name": "eIF-2alpha", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P05198" }, { "name": "eIF2-alpha", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P05198" }, { "name": "eukaryotic translation initiation factor 2 subunit 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004085", "id": "NP_004085" } ], "function": [ { "annotation": "Activation of BZW1 by CEBPB in macrophages promotes eIF2alpha phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_004085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004085" }, { "database": "PubMed", "id": "37828427", "url": "https://glygen.org/publication/PubMed/37828427" } ] }, { "annotation": "C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2alpha. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_004085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004085" }, { "database": "PubMed", "id": "36438488", "url": "https://glygen.org/publication/PubMed/36438488" } ] }, { "annotation": "Helicobacter pylori Targets in AGS Human Gastric Adenocarcinoma: In Situ Proteomic Profiling and Systematic Analysis.", "evidence": [ { "database": "RefSeq", "id": "NP_004085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004085" }, { "database": "PubMed", "id": "34969763", "url": "https://glygen.org/publication/PubMed/34969763" } ] }, { "annotation": "Higher-order phosphatase-substrate contacts terminate the integrated stress response.", "evidence": [ { "database": "RefSeq", "id": "NP_004085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004085" }, { "database": "PubMed", "id": "34625748", "url": "https://glygen.org/publication/PubMed/34625748" } ] }, { "annotation": "Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:16289705). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (43S PIC) (PubMed:16289705). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (PubMed:16289705). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (PubMed:16289705). EIF2S1/ component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF2-alpha in a global protein synthesis inhibitor, leading to an attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:19131336, PubMed:33384352).", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198#function" }, { "database": "PubMed", "id": "19131336", "url": "https://glygen.org/publication/PubMed/19131336" }, { "database": "PubMed", "id": "33384352", "url": "https://glygen.org/publication/PubMed/33384352" }, { "database": "PubMed", "id": "16289705", "url": "https://glygen.org/publication/PubMed/16289705" } ] }, { "annotation": "PERK-eIF2alpha-ERK1/2 axis drives mesenchymal-endothelial transition of cancer-associated fibroblasts in pancreatic cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_004085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004085" }, { "database": "PubMed", "id": "34052329", "url": "https://glygen.org/publication/PubMed/34052329" } ] }, { "annotation": "The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010].", "evidence": [ { "database": "RefSeq", "id": "NP_004085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004085" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs1223353630", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1223353630" }, { "id": "rs1223353630", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1223353630" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 219, "end_pos": 219, "sequence_org": "S", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NCS->NCA); o-glyco-site-loss (S->A).", "chr_id": "14", "chr_pos": "67381667", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S219", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs755183847", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs755183847" }, { "id": "rs755183847", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs755183847" }, { "id": "rs755183847", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs755183847#frequency_tab" }, { "id": "rs755183847", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs755183847" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 224, "end_pos": 224, "sequence_org": "P", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NMP->NMS).", "chr_id": "14", "chr_pos": "67381682", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P224", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs199731295", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs199731295" }, { "id": "rs199731295", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs199731295" }, { "id": "rs199731295", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs199731295#frequency_tab" }, { "id": "rs199731295", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs199731295" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 239, "end_pos": 239, "sequence_org": "T", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->A).", "chr_id": "14", "chr_pos": "67382483", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T239", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "P05198", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P05198" }, { "id": "rs1452482004", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1452482004" }, { "id": "rs1452482004", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1452482004" }, { "id": "rs1452482004", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1452482004" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 239, "end_pos": 239, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "T", "sequence_mut": "M", "comment": "Somatic mutation passed 1 out of 6 filters: o-glyco-site-loss (T->M).", "chr_id": "14", "chr_pos": "67382484", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "T239", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] }, { "evidence": [ { "id": "rs1369915275", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1369915275" }, { "id": "rs1369915275", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1369915275#frequency_tab" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 240, "end_pos": 240, "sequence_org": "T", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->A).", "chr_id": "14", "chr_pos": "67382486", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T240", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs756171865", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs756171865" }, { "id": "rs756171865", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs756171865" }, { "id": "rs756171865", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs756171865" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 241, "end_pos": 241, "sequence_org": "T", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->A).", "chr_id": "14", "chr_pos": "67382489", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T241", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "92.15", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000134001", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134001" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "93.95", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000134001", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134001" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "93.41", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000134001", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134001" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "78.77", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000134001", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134001" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "97.18", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000134001", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134001" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "96.52", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000134001", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134001" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "90.81", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000134001", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134001" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "95.22", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000134001", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134001" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "93.72", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000134001", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134001" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "90.16", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000134001", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134001" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "94.35", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000134001", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134001" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "93.53", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000134001", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134001" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "94.73", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000134001", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134001" } ] } ], "expression_disease": [ { "significant": "No", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P05198", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05198" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P05198", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05198" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "P05198", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05198" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "P05198", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05198" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "P05198", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05198" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "P05198", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05198" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P05198", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05198" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "P05198", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05198" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "P05198", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05198" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Uterine cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:363", "evidence": [ { "database": "BioXpress", "id": "P05198", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05198" } ], "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Esophageal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:5041", "evidence": [ { "database": "BioXpress", "id": "P05198", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05198" } ], "disease": [ { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Aerodigestive tract cancer, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Escc, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "gastric cardia adenocarcinoma, susceptibility to", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Colorectal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:9256", "evidence": [ { "database": "BioXpress", "id": "P05198", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05198" } ], "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "common_name": "Human" } ], "gene": [ { "name": "EIF2S1", "url": "https://www.uniprot.org/uniprot/P05198", "locus": { "chromosome": "14", "start_pos": 67386516, "end_pos": 67360328, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000134001", "url": "https://www.ensembl.org/id/ENSG00000134001" } ] } } ], "crossref": [ { "id": "ENSG00000134001", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134001", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "P05198", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P05198", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "3.6.5.3", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.5.3&UniProtAcc=P05198", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd04452", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04452", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL1255131", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL1255131", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "EIF2S1", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=EIF2S1", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "1965", "url": "https://www.ncbi.nlm.nih.gov/gene/1965", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "3265", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3265", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "P05198", "url": "https://www.ebi.ac.uk/intact/interactors/id:P05198*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR003029", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003029", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011488", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011488", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024054", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024054", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:1965", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:1965", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "603907", "url": "http://www.omim.org/entry/603907", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_P05198", "url": "https://www.nextprot.org/entry/NX_P05198", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "P05198", "url": "https://oglcnac.org/atlas/detail/P05198", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "P05198", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05198", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "DVNEHQR", "url": "https://omabrowser.org/oma/group/DVNEHQR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4371132at2759", "url": "http://www.orthodb.org/?query=4371132at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10602", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10602", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10602:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10602:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "1KL9", "url": "https://www.rcsb.org/structure/1KL9", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1Q8K", "url": "https://www.rcsb.org/structure/1Q8K", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6K71", "url": "https://www.rcsb.org/structure/6K71", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6K72", "url": "https://www.rcsb.org/structure/6K72", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6O81", "url": "https://www.rcsb.org/structure/6O81", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6O85", "url": "https://www.rcsb.org/structure/6O85", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6O9Z", "url": "https://www.rcsb.org/structure/6O9Z", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6YBV", "url": "https://www.rcsb.org/structure/6YBV", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6ZMW", "url": "https://www.rcsb.org/structure/6ZMW", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6ZP4", "url": "https://www.rcsb.org/structure/6ZP4", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7A09", "url": "https://www.rcsb.org/structure/7A09", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7D43", "url": "https://www.rcsb.org/structure/7D43", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7D44", "url": "https://www.rcsb.org/structure/7D44", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7D45", "url": "https://www.rcsb.org/structure/7D45", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7F66", "url": "https://www.rcsb.org/structure/7F66", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7F67", "url": "https://www.rcsb.org/structure/7F67", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7NZM", "url": "https://www.rcsb.org/structure/7NZM", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7QP6", "url": "https://www.rcsb.org/structure/7QP6", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7QP7", "url": "https://www.rcsb.org/structure/7QP7", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7SYR", "url": "https://www.rcsb.org/structure/7SYR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7SYS", "url": "https://www.rcsb.org/structure/7SYS", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00575", "url": "http://pfam.xfam.org/family/PF00575", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07541", "url": "http://pfam.xfam.org/family/PF07541", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P05198", "url": "https://pharos.nih.gov/targets/P05198", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_P05198", "url": "http://purl.obolibrary.org/obo/PR_P05198", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156827", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-381042", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381042", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-72649", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72649", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-72695", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72695", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-72702", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72702", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72706", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-72731", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72731", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9633012", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9633012", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9648895", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648895", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9840373", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9840373", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_004085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004085", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "G3V4T5", "url": "https://www.uniprot.org/uniprot/G3V4T5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3V4T5-1", "url": "https://www.uniprot.org/uniprot/G3V4T5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YJS4", "url": "https://www.uniprot.org/uniprot/H0YJS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YJS4-1", "url": "https://www.uniprot.org/uniprot/H0YJS4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P05198-1", "url": "https://www.uniprot.org/uniprot/P05198-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLSQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQMERLERENAEVDGDDDAEEMEAKAED", "length": 315, "header": "sp|P05198-1|IF2A_HUMAN Isoform 1 of Eukaryotic translation initiation factor 2 subunit 1 OS=Homo sapiens OX=9606 GN=EIF2S1 PE=1 SV=3 CANONICAL=P05198-1" }, "isoforms": [ { "isoform_ac": "G3V4T5-1", "url": "", "sequence": { "sequence": "MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLSQAMAVIKEKIEEKRGVFNVQM", "length": 273, "header": "tr|G3V4T5-1|G3V4T5_HUMAN Computationally mapped isoform of Eukaryotic translation initiation factor 2 subunit 1 OS=Homo sapiens OX=9606 GN=EIF2S1 PE=1 SV=1 CANONICAL=P05198-1" }, "locus": { "chromosome": "14", "start_pos": 67382587, "end_pos": 67364768, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000557310.5", "url": "https://www.ensembl.org/id/ENST00000557310.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000451975.1", "url": "https://www.ensembl.org/id/ENSP00000451975.1" } ] } }, { "isoform_ac": "H0YJS4-1", "url": "", "sequence": { "sequence": "XMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLSQAMAVIKEKIEEKRGVFNVQMEVRSIDSFLIMTQEVPKRSSCR", "length": 252, "header": "tr|H0YJS4-1|H0YJS4_HUMAN Computationally mapped isoform of Eukaryotic translation initiation factor 2 subunit 1 OS=Homo sapiens OX=9606 GN=EIF2S1 PE=1 SV=1 CANONICAL=P05198-1" }, "locus": { "chromosome": "14", "start_pos": 67382654, "end_pos": 67364898, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000555876.1", "url": "https://www.ensembl.org/id/ENST00000555876.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000452034.1", "url": "https://www.ensembl.org/id/ENSP00000452034.1" } ] } }, { "isoform_ac": "P05198-1", "url": "", "sequence": { "sequence": "MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLSQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQMERLERENAEVDGDDDAEEMEAKAED", "length": 315, "header": "sp|P05198-1|IF2A_HUMAN Isoform 1 of Eukaryotic translation initiation factor 2 subunit 1 OS=Homo sapiens OX=9606 GN=EIF2S1 PE=1 SV=3 CANONICAL=P05198-1" }, "locus": { "chromosome": "14", "start_pos": 67383437, "end_pos": 67364768, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000256383.11", "url": "https://www.ensembl.org/id/ENST00000256383.11" }, { "database": "Ensembl Peptide", "id": "ENSP00000256383.4", "url": "https://www.ensembl.org/id/ENSP00000256383.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 217, "start_aa": "Asn", "end_pos": 217, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn217", "evidence": [ { "id": "24190977", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24190977" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 219, "start_aa": "Ser", "end_pos": 219, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser219", "evidence": [ { "id": "P05198", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05198" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "25937070", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/25937070" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "32119511", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32119511" }, { "id": "28657654", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28657654" }, { "id": "P05198", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P05198" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 239, "start_aa": "Thr", "end_pos": 239, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr239", "evidence": [ { "id": "P05198", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05198" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "25937070", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/25937070" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "32119511", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32119511" }, { "id": "28657654", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28657654" }, { "id": "P05198", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P05198" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 240, "start_aa": "Thr", "end_pos": 240, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr240", "evidence": [ { "id": "P05198", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05198" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "25937070", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/25937070" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "32119511", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32119511" }, { "id": "28657654", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28657654" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 241, "start_aa": "Thr", "end_pos": 241, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr241", "evidence": [ { "id": "P05198", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05198" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "25937070", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/25937070" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "32119511", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32119511" }, { "id": "28657654", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28657654" }, { "id": "P05198", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P05198" } ] } ], "phosphorylation": [ { "start_pos": 158, "end_pos": 158, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "site_lbl": "Ser158" }, { "start_pos": 279, "end_pos": 279, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "site_lbl": "Thr279" }, { "start_pos": 281, "end_pos": 281, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "site_lbl": "Thr281" }, { "start_pos": 49, "end_pos": 49, "kinase_uniprot_canonical_ac": "P19525-1", "kinase_gene_name": "EIF2AK2", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "P05198", "url": "http://phospho.elm.eu.org/byAccession/P05198.html" }, { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" }, { "database": "PubMed", "id": "16288713", "url": "https://glygen.org/publication/PubMed/16288713" } ], "site_lbl": "Ser49" }, { "start_pos": 49, "end_pos": 49, "kinase_uniprot_canonical_ac": "Q9BQI3-1", "kinase_gene_name": "EIF2AK1", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" }, { "database": "PubMed", "id": "10563826", "url": "https://glygen.org/publication/PubMed/10563826" }, { "database": "PubMed", "id": "3352609", "url": "https://glygen.org/publication/PubMed/3352609" } ], "site_lbl": "Ser49" }, { "start_pos": 49, "end_pos": 49, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by HRI", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" }, { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" }, { "database": "PubMed", "id": "2116318", "url": "https://glygen.org/publication/PubMed/2116318" }, { "database": "phospho.ELM", "id": "P05198", "url": "http://phospho.elm.eu.org/byAccession/P05198.html" }, { "database": "PubMed", "id": "3352609", "url": "https://glygen.org/publication/PubMed/3352609" } ], "site_lbl": "Ser49" }, { "start_pos": 52, "end_pos": 52, "kinase_uniprot_canonical_ac": "P19525-1", "kinase_gene_name": "EIF2AK2", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" }, { "database": "PubMed", "id": "10542257", "url": "https://glygen.org/publication/PubMed/10542257" }, { "database": "PubMed", "id": "16179258", "url": "https://glygen.org/publication/PubMed/16179258" }, { "database": "PubMed", "id": "1677563", "url": "https://glygen.org/publication/PubMed/1677563" }, { "database": "PubMed", "id": "9819435", "url": "https://glygen.org/publication/PubMed/9819435" }, { "database": "phospho.ELM", "id": "P05198", "url": "http://phospho.elm.eu.org/byAccession/P05198.html" }, { "database": "PubMed", "id": "11432733", "url": "https://glygen.org/publication/PubMed/11432733" }, { "database": "PubMed", "id": "16179259", "url": "https://glygen.org/publication/PubMed/16179259" } ], "site_lbl": "Ser52" }, { "start_pos": 52, "end_pos": 52, "kinase_uniprot_canonical_ac": "P28482-1", "kinase_gene_name": "MAPK1", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" }, { "database": "PubMed", "id": "17404396", "url": "https://glygen.org/publication/PubMed/17404396" } ], "site_lbl": "Ser52" }, { "start_pos": 52, "end_pos": 52, "kinase_uniprot_canonical_ac": "Q05655-1", "kinase_gene_name": "PRKCD", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" }, { "database": "PubMed", "id": "10542257", "url": "https://glygen.org/publication/PubMed/10542257" }, { "database": "PubMed", "id": "1677563", "url": "https://glygen.org/publication/PubMed/1677563" }, { "database": "PubMed", "id": "9819435", "url": "https://glygen.org/publication/PubMed/9819435" } ], "site_lbl": "Ser52" }, { "start_pos": 52, "end_pos": 52, "kinase_uniprot_canonical_ac": "Q16539-1", "kinase_gene_name": "MAPK14", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" }, { "database": "PubMed", "id": "17404396", "url": "https://glygen.org/publication/PubMed/17404396" } ], "site_lbl": "Ser52" }, { "start_pos": 52, "end_pos": 52, "kinase_uniprot_canonical_ac": "Q9BQI3-1", "kinase_gene_name": "EIF2AK1", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" }, { "database": "PubMed", "id": "10542257", "url": "https://glygen.org/publication/PubMed/10542257" }, { "database": "PubMed", "id": "1677563", "url": "https://glygen.org/publication/PubMed/1677563" }, { "database": "PubMed", "id": "9819435", "url": "https://glygen.org/publication/PubMed/9819435" }, { "database": "PubMed", "id": "11041858", "url": "https://glygen.org/publication/PubMed/11041858" }, { "database": "PubMed", "id": "3352609", "url": "https://glygen.org/publication/PubMed/3352609" } ], "site_lbl": "Ser52" }, { "start_pos": 52, "end_pos": 52, "kinase_uniprot_canonical_ac": "Q9NZJ5-1", "kinase_gene_name": "EIF2AK3", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" }, { "database": "PubMed", "id": "10542257", "url": "https://glygen.org/publication/PubMed/10542257" }, { "database": "PubMed", "id": "1677563", "url": "https://glygen.org/publication/PubMed/1677563" }, { "database": "PubMed", "id": "8099443", "url": "https://glygen.org/publication/PubMed/8099443" }, { "database": "PubMed", "id": "9819435", "url": "https://glygen.org/publication/PubMed/9819435" }, { "database": "PubMed", "id": "11907036", "url": "https://glygen.org/publication/PubMed/11907036" }, { "database": "phospho.ELM", "id": "P05198", "url": "http://phospho.elm.eu.org/byAccession/P05198.html" }, { "database": "PubMed", "id": "17998206", "url": "https://glygen.org/publication/PubMed/17998206" }, { "database": "PubMed", "id": "25660019", "url": "https://glygen.org/publication/PubMed/25660019" }, { "database": "PubMed", "id": "30070006", "url": "" } ], "site_lbl": "Ser52" }, { "start_pos": 52, "end_pos": 52, "kinase_uniprot_canonical_ac": "Q9P2K8-1", "kinase_gene_name": "EIF2AK4", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" }, { "database": "PubMed", "id": "10504407", "url": "https://glygen.org/publication/PubMed/10504407" }, { "database": "PubMed", "id": "15355306", "url": "https://glygen.org/publication/PubMed/15355306" }, { "database": "PubMed", "id": "15684420", "url": "https://glygen.org/publication/PubMed/15684420" }, { "database": "PubMed", "id": "32513922", "url": "" } ], "site_lbl": "Ser52" }, { "start_pos": 52, "end_pos": 52, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" }, { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" }, { "database": "PubMed", "id": "10542257", "url": "https://glygen.org/publication/PubMed/10542257" }, { "database": "PubMed", "id": "1677563", "url": "https://glygen.org/publication/PubMed/1677563" }, { "database": "PubMed", "id": "9819435", "url": "https://glygen.org/publication/PubMed/9819435" }, { "database": "phospho.ELM", "id": "P05198", "url": "http://phospho.elm.eu.org/byAccession/P05198.html" }, { "database": "PubMed", "id": "11337501", "url": "https://glygen.org/publication/PubMed/11337501" }, { "database": "PubMed", "id": "9930704", "url": "https://glygen.org/publication/PubMed/9930704" }, { "database": "PubMed", "id": "3352609", "url": "https://glygen.org/publication/PubMed/3352609" }, { "database": "PRO", "id": "P05198", "url": "http://purl.obolibrary.org/obo/P05198" } ], "site_lbl": "Ser52" }, { "start_pos": 58, "end_pos": 58, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser58" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan", "glycoprotein_reported" ], "publication": [ { "title": "Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Shi Y, An J, Liang J, Hayes SE, Sandusky GE, Stramm LE, Yang NN", "evidence": [ { "database": "Reactome", "id": "R-HSA-381042", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381042" } ], "reference": [ { "type": "PubMed", "id": "10026192", "url": "https://glygen.org/publication/PubMed/10026192" } ] }, { "title": "Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53.", "journal": "Molecular and cellular biology", "date": "1999-04", "authors": "Cuddihy A R, Li S, Tam N W, Wong A H, Taya Y, Abraham N, Bell J C, Koromilas A E", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "10082513", "url": "https://glygen.org/publication/PubMed/10082513" } ] }, { "title": "The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro.", "journal": "Oncogene", "date": "1999", "authors": "Cuddihy AR, Wong AH, Tam NW, Li S, Koromilas AE", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "10348343", "url": "https://glygen.org/publication/PubMed/10348343" } ] }, { "title": "Ded1p, a DEAD-box protein required for translation initiation in Saccharomyces cerevisiae, is an RNA helicase.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Iost I, Dreyfus M, Linder P", "evidence": [ { "database": "Reactome", "id": "R-HSA-72702", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72702" } ], "reference": [ { "type": "PubMed", "id": "10364207", "url": "https://glygen.org/publication/PubMed/10364207" } ] }, { "title": "DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR.", "journal": "The Journal of biological chemistry", "date": "1999-07-16", "authors": "Patel R C, Vestal D J, Xu Z, Bandyopadhyay S, Guo W, Erme S M, Williams B R, Sen G C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "10400669", "url": "https://glygen.org/publication/PubMed/10400669" } ] }, { "title": "Profound differences in the transport of steroids by two mouse P-glycoproteins.", "journal": "Biochemical pharmacology", "date": "1999", "authors": "Gruol DJ, Vo QD, Zee MC", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "10484077", "url": "https://glygen.org/publication/PubMed/10484077" } ] }, { "title": "Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase.", "journal": "European journal of biochemistry", "date": "1999", "authors": "Berlanga JJ, Santoyo J, De Haro C", "evidence": [ { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "reference": [ { "type": "PubMed", "id": "10504407", "url": "https://glygen.org/publication/PubMed/10504407" } ] }, { "title": "The interferon-induced double-stranded RNA-activated protein kinase PKR will phosphorylate serine, threonine, or tyrosine at residue 51 in eukaryotic initiation factor 2alpha.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Lu J, O'Hara EB, Trieselmann BA, Romano PR, Dever TE", "evidence": [ { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "reference": [ { "type": "PubMed", "id": "10542257", "url": "https://glygen.org/publication/PubMed/10542257" } ] }, { "title": "Serine 48 in initiation factor 2 alpha (eIF2 alpha) is required for high-affinity interaction between eIF2 alpha(P) and eIF2B.", "journal": "Biochemistry", "date": "1999", "authors": "Sudhakar A, Krishnamoorthy T, Jain A, Chatterjee U, Hasnain SE, Kaufman RJ, Ramaiah KV", "evidence": [ { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "reference": [ { "type": "PubMed", "id": "10563826", "url": "https://glygen.org/publication/PubMed/10563826" } ] }, { "title": "HIV-I TAT inhibits PKR activity by both RNA-dependent and RNA-independent mechanisms.", "journal": "Archives of biochemistry and biophysics", "date": "2000-01-15", "authors": "Cai R, Carpick B, Chun R F, Jeang K T, Williams B R", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "10620360", "url": "https://glygen.org/publication/PubMed/10620360" } ] }, { "title": "JNK2 and IKKbeta are required for activating the innate response to viral infection.", "journal": "Immunity", "date": "1999-12", "authors": "Chu W M, Ostertag D, Li Z W, Chang L, Chen Y, Hu Y, Williams B, Perrault J, Karin M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "10626894", "url": "https://glygen.org/publication/PubMed/10626894" } ] }, { "title": "NF-kappaB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase.", "journal": "Molecular and cellular biology", "date": "2000-02", "authors": "Zamanian-Daryoush M, Mogensen T H, DiDonato J A, Williams B R", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "10648614", "url": "https://glygen.org/publication/PubMed/10648614" } ] }, { "title": "The joining of ribosomal subunits in eukaryotes requires eIF5B.", "journal": "Nature", "date": "2000", "authors": "Pestova TV, Lomakin IB, Lee JH, Choi SK, Dever TE, Hellen CU", "evidence": [ { "database": "Reactome", "id": "R-HSA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72706" } ], "reference": [ { "type": "PubMed", "id": "10659855", "url": "https://glygen.org/publication/PubMed/10659855" } ] }, { "title": "Interaction of docetaxel (`Taxotere`) with human P-glycoprotein.", "journal": "Japanese journal of cancer research : Gann", "date": "1999", "authors": "Shirakawa K, Takara K, Tanigawara Y, Aoyama N, Kasuga M, Komada F, Sakaeda T, Okumura K", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "10665657", "url": "https://glygen.org/publication/PubMed/10665657" } ] }, { "title": "Characterization of ABCB9, an ATP binding cassette protein associated with lysosomes.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Zhang F, Zhang W, Liu L, Fisher CL, Hui D, Childs S, Dorovini-Zis K, Ling V", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "10748049", "url": "https://glygen.org/publication/PubMed/10748049" } ] }, { "title": "PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.", "journal": "Molecular and cellular biology", "date": "2000-07", "authors": "Bonnet M C, Weil R, Dam E, Hovanessian A G, Meurs E F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "10848580", "url": "https://glygen.org/publication/PubMed/10848580" } ] }, { "title": "The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR.", "journal": "Molecular and cellular biology", "date": "2000", "authors": "Xu Z, Williams BR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "10866685", "url": "https://glygen.org/publication/PubMed/10866685" } ] }, { "title": "Purification and characterization of homogeneous initiation factor M2A from rabbit reticulocytes.", "journal": "The Journal of biological chemistry", "date": "1975", "authors": "Merrick WC, Kemper WM, Anderson WF", "evidence": [ { "database": "Reactome", "id": "R-HSA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72706" } ], "reference": [ { "type": "PubMed", "id": "1095581", "url": "https://glygen.org/publication/PubMed/1095581" } ] }, { "title": "Amino acids control mammalian gene transcription: activating transcription factor 2 is essential for the amino acid responsiveness of the CHOP promoter.", "journal": "Molecular and cellular biology", "date": "2000", "authors": "Bruhat A, Jousse C, Carraro V, Reimold AM, Ferrara M, Fafournoux P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9633012", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9633012" } ], "reference": [ { "type": "PubMed", "id": "10982836", "url": "https://glygen.org/publication/PubMed/10982836" } ] }, { "title": "A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo.", "journal": "Genes & development", "date": "2000", "authors": "Asano K, Clayton J, Shalev A, Hinnebusch AG", "evidence": [ { "database": "Reactome", "id": "R-HSA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72706" } ], "reference": [ { "type": "PubMed", "id": "11018020", "url": "https://glygen.org/publication/PubMed/11018020" } ] }, { "title": "Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Podust LM, Krezel AM, Kim Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-9633012", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9633012" } ], "reference": [ { "type": "PubMed", "id": "11018027", "url": "https://glygen.org/publication/PubMed/11018027" } ] }, { "title": "Phosphorylation of serine 51 in initiation factor 2 alpha (eIF2 alpha) promotes complex formation between eIF2 alpha(P) and eIF2B and causes inhibition in the guanine nucleotide exchange activity of eIF2B.", "journal": "Biochemistry", "date": "2000", "authors": "Sudhakar A, Ramachandran A, Ghosh S, Hasnain SE, Kaufman RJ, Ramaiah KV", "evidence": [ { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "reference": [ { "type": "PubMed", "id": "11041858", "url": "https://glygen.org/publication/PubMed/11041858" } ] }, { "title": "Binding of MET-TRNAf and GTP to homogeneous initiation factor MP.", "journal": "The Journal of biological chemistry", "date": "1975", "authors": "Safer B, Adams SL, Anderson WF, Merrick WC", "evidence": [ { "database": "Reactome", "id": "R-HSA-72695", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72695" } ], "reference": [ { "type": "PubMed", "id": "1104615", "url": "https://glygen.org/publication/PubMed/1104615" } ] }, { "title": "A Role of RNA Helicase A in cis-Acting Transactivation Response Element-mediated Transcriptional Regulation of Human Immunodeficiency Virus Type 1.", "journal": "The Journal of biological chemistry", "date": "2001-02-23", "authors": "Fujii R, Okamoto M, Aratani S, Oishi T, Ohshima T, Taira K, Baba M, Fukamizu A, Nakajima T", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "11096080", "url": "https://glygen.org/publication/PubMed/11096080" } ] }, { "title": "Functional characterization of and cooperation between the double-stranded RNA-binding motifs of the protein kinase PKR.", "journal": "The Journal of biological chemistry", "date": "2001-03-30", "authors": "Tian B, Mathews M B", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "11134010", "url": "https://glygen.org/publication/PubMed/11134010" } ] }, { "title": "Hepatitis C virus envelope protein E2 does not inhibit PKR by simple competition with autophosphorylation sites in the RNA-binding domain.", "journal": "Journal of virology", "date": "2001", "authors": "Taylor DR, Tian B, Romano PR, Hinnebusch AG, Lai MM, Mathews MB", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "11152499", "url": "https://glygen.org/publication/PubMed/11152499" } ] }, { "title": "Identification of the interferon-inducible double-stranded RNA-dependent protein kinase as a regulator of cellular response to bulky adducts.", "journal": "Cancer research", "date": "2000-12-15", "authors": "Bergeron J, Benlimame N, Zeng-Rong N, Xiao D, Scrivens P J, Koromilas A E, Alaoui-Jamali M A", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "11156368", "url": "https://glygen.org/publication/PubMed/11156368" } ] }, { "title": "Peroxynitrite induces GADD34, 45, and 153 VIA p38 MAPK in human neuroblastoma SH-SY5Y cells.", "journal": "Free radical biology & medicine", "date": "2001", "authors": "Oh-Hashi K, Maruyama W, Isobe K", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648895", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648895" } ], "reference": [ { "type": "PubMed", "id": "11163539", "url": "https://glygen.org/publication/PubMed/11163539" } ] }, { "title": "Role of double-stranded RNA-dependent protein kinase in mediating hypersensitivity of Fanconi anemia complementation group C cells to interferon gamma, tumor necrosis factor-alpha, and double-stranded RNA.", "journal": "Blood", "date": "2001-03-15", "authors": "Pang Q, Keeble W, Diaz J, Christianson T A, Fagerlie S, Rathbun K, Faulkner G R, O'Dwyer M, Bagby G C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "11238103", "url": "https://glygen.org/publication/PubMed/11238103" } ] }, { "title": "Modular structure of PACT: distinct domains for binding and activating PKR.", "journal": "Molecular and cellular biology", "date": "2001-03", "authors": "Peters G A, Hartmann R, Qin J, Sen G C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "11238927", "url": "https://glygen.org/publication/PubMed/11238927" } ] }, { "title": "Activation of Gadd34 by diverse apoptotic signals and suppression of its growth inhibitory effects by apoptotic inhibitors.", "journal": "International journal of cancer", "date": "2001", "authors": "Hollander MC, Sheikh MS, Yu K, Zhan Q, Iglesias M, Woodworth C, Fornace AJ Jr", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648895", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648895" } ], "reference": [ { "type": "PubMed", "id": "11241327", "url": "https://glygen.org/publication/PubMed/11241327" } ] }, { "title": "Enhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKR.", "journal": "The Journal of biological chemistry", "date": "2001-04-27", "authors": "Wong A H, Durbin J E, Li S, Dever T E, Decker T, Koromilas A E", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "11278865", "url": "https://glygen.org/publication/PubMed/11278865" } ] }, { "title": "The catalytic activity of dsRNA-dependent protein kinase, PKR, is required for NF-kappaB activation.", "journal": "Oncogene", "date": "2001-01-18", "authors": "Gil J, Rullas J, Garc\u00eda M A, Alcam\u00ed J, Esteban M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "11313968", "url": "https://glygen.org/publication/PubMed/11313968" } ] }, { "title": "Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Zhang F, Romano PR, Nagamura-Inoue T, Tian B, Dever TE, Mathews MB, Ozato K, Hinnebusch AG", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" }, { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "reference": [ { "type": "PubMed", "id": "11337501", "url": "https://glygen.org/publication/PubMed/11337501" } ] }, { "title": "Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3.", "journal": "The EMBO journal", "date": "2001", "authors": "Deb A, Zamanian-Daryoush M, Xu Z, Kadereit S, Williams BR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "11350938", "url": "https://glygen.org/publication/PubMed/11350938" } ] }, { "title": "Mechanism of activation of the double-stranded-RNA-dependent protein kinase, PKR: role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic initiation factor-2 (eIF2).", "journal": "European journal of biochemistry", "date": "2001", "authors": "Vattem KM, Staschke KA, Wek RC", "evidence": [ { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "reference": [ { "type": "PubMed", "id": "11432733", "url": "https://glygen.org/publication/PubMed/11432733" } ] }, { "title": "Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase.", "journal": "The Journal of biological chemistry", "date": "2001-08-31", "authors": "Parker L M, Fierro-Monti I, Mathews M B", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "11438540", "url": "https://glygen.org/publication/PubMed/11438540" } ] }, { "title": "FANCC interacts with Hsp70 to protect hematopoietic cells from IFN-gamma/TNF-alpha-mediated cytotoxicity.", "journal": "The EMBO journal", "date": "2001-08-15", "authors": "Pang Q, Keeble W, Christianson T A, Faulkner G R, Bagby G C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "11500375", "url": "https://glygen.org/publication/PubMed/11500375" } ] }, { "title": "Kinetics of P-glycoprotein-mediated efflux of paclitaxel.", "journal": "The Journal of pharmacology and experimental therapeutics", "date": "2001", "authors": "Jang SH, Wientjes MG, Au JL", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "11504826", "url": "https://glygen.org/publication/PubMed/11504826" } ] }, { "title": "Na+:HCO(3-) cotransporters (NBC): cloning and characterization.", "journal": "The Journal of membrane biology", "date": "2001", "authors": "Soleimani M, Burnham CE", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "11562789", "url": "https://glygen.org/publication/PubMed/11562789" } ] }, { "title": "CCAAT/enhancer-binding protein-beta is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Siu F, Chen C, Zhong C, Kilberg MS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9633012", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9633012" } ], "reference": [ { "type": "PubMed", "id": "11677247", "url": "https://glygen.org/publication/PubMed/11677247" } ] }, { "title": "Inhibition of CHOP translation by a peptide encoded by an open reading frame localized in the chop 5'UTR.", "journal": "Nucleic acids research", "date": "2001", "authors": "Jousse C, Bruhat A, Carraro V, Urano F, Ferrara M, Ron D, Fafournoux P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9633012", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9633012" } ], "reference": [ { "type": "PubMed", "id": "11691921", "url": "https://glygen.org/publication/PubMed/11691921" } ] }, { "title": "Double-stranded RNA-dependent protein kinase, PKR, down-regulates CDC2/cyclin B1 and induces apoptosis in non-transformed but not in v-mos transformed cells.", "journal": "Oncogene", "date": "2001-12-06", "authors": "Dagon Y, Dovrat S, Vilchik S, Hacohen D, Shlomo G, Sredni B, Salzberg S, Nir U", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "11781817", "url": "https://glygen.org/publication/PubMed/11781817" } ] }, { "title": "A principal role for the proteasome in endoplasmic reticulum-associated degradation of misfolded intracellular cystic fibrosis transmembrane conductance regulator.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Gelman MS, Kannegaard ES, Kopito RR", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "11812794", "url": "https://glygen.org/publication/PubMed/11812794" } ] }, { "title": "Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha.", "journal": "J. Biol. Chem.", "date": "2002", "authors": "Nonato M Cristina, Widom Joanne, Clardy Jon", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "reference": [ { "type": "PubMed", "id": "11859078", "url": "https://glygen.org/publication/PubMed/11859078" } ] }, { "title": "Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Ma K, Vattem KM, Wek RC", "evidence": [ { "database": "Reactome", "id": "R-HSA-381042", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381042" }, { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "reference": [ { "type": "PubMed", "id": "11907036", "url": "https://glygen.org/publication/PubMed/11907036" } ] }, { "title": "Gene-specific regulation by general translation factors.", "journal": "Cell", "date": "2002-02-22", "authors": "Dever Thomas E", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "11909525", "url": "https://glygen.org/publication/PubMed/11909525" } ] }, { "title": "Inactivation of the PKR protein kinase and stimulation of mRNA translation by the cellular co-chaperone P58(IPK) does not require J domain function.", "journal": "Biochemistry", "date": "2002-04-16", "authors": "Yan Wei, Gale Michael J, Tan Seng-Lai, Katze Michael G", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "11939789", "url": "https://glygen.org/publication/PubMed/11939789" } ] }, { "title": "The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR).", "journal": "The Biochemical journal", "date": "2002-08-15", "authors": "Huang Xu, Hutchins Brian, Patel Rekha C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "11985496", "url": "https://glygen.org/publication/PubMed/11985496" } ] }, { "title": "Contribution of double-stranded RNA-activated protein kinase toward antiproliferative actions of heparin on vascular smooth muscle cells.", "journal": "Arteriosclerosis, thrombosis, and vascular biology", "date": "2002-09-01", "authors": "Patel Rekha C, Handy Indhira, Patel Chandrashekhar V", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "12231563", "url": "https://glygen.org/publication/PubMed/12231563" } ] }, { "title": "Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha.", "journal": "Molecular and cellular biology", "date": "2002", "authors": "Koumenis C, Naczki C, Koritzinsky M, Rastani S, Diehl A, Sonenberg N, Koromilas A, Wouters BG", "evidence": [ { "database": "Reactome", "id": "R-HSA-381042", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381042" } ], "reference": [ { "type": "PubMed", "id": "12370288", "url": "https://glygen.org/publication/PubMed/12370288" } ] }, { "title": "Functional analysis of ABCA8, a new drug transporter.", "journal": "Biochemical and biophysical research communications", "date": "2002", "authors": "Tsuruoka S, Ishibashi K, Yamamoto H, Wakaumi M, Suzuki M, Schwartz GJ, Imai M, Fujimura A", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "12379217", "url": "https://glygen.org/publication/PubMed/12379217" } ] }, { "title": "The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone.", "journal": "The Journal of endocrinology", "date": "2002", "authors": "Karssen AM, Meijer OC, van der Sandt IC, De Boer AG, De Lange EC, De Kloet ER", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "12379510", "url": "https://glygen.org/publication/PubMed/12379510" } ] }, { "title": "The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC.", "journal": "The Journal of biological chemistry", "date": "2002-12-20", "authors": "Pang Qishen, Christianson Tracy A, Keeble Winifred, Koretsky Tara, Bagby Grover C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "12397061", "url": "https://glygen.org/publication/PubMed/12397061" } ] }, { "title": "The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Park M, Ko SB, Choi JY, Muallem G, Thomas PJ, Pushkin A, Lee MS, Kim JY, Lee MG, Muallem S, Kurtz I", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "12403779", "url": "https://glygen.org/publication/PubMed/12403779" } ] }, { "title": "Transcript-selective translational silencing by gamma interferon is directed by a novel structural element in the ceruloplasmin mRNA 3' untranslated region.", "journal": "Molecular and cellular biology", "date": "2003", "authors": "Sampath P, Mazumder B, Seshadri V, Fox PL", "evidence": [ { "database": "Reactome", "id": "R-HSA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156827" } ], "reference": [ { "type": "PubMed", "id": "12588972", "url": "https://glygen.org/publication/PubMed/12588972" } ] }, { "title": "Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux.", "journal": "The Journal of pharmacology and experimental therapeutics", "date": "2003", "authors": "Dai H, Marbach P, Lemaire M, Hayes M, Elmquist WF", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "12604685", "url": "https://glygen.org/publication/PubMed/12604685" } ] }, { "title": "Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Pang Q, Christianson TA, Koretsky T, Carlson H, David L, Keeble W, Faulkner GR, Speckhart A, Bagby GC", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "12882984", "url": "https://glygen.org/publication/PubMed/12882984" } ] }, { "title": "Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1992", "authors": "Mechetner EB, Roninson IB", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "1352877", "url": "https://glygen.org/publication/PubMed/1352877" } ] }, { "title": "Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1992", "authors": "Ambudkar SV, Lelong IH, Zhang J, Cardarelli CO, Gottesman MM, Pastan I", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "1356264", "url": "https://glygen.org/publication/PubMed/1356264" } ] }, { "title": "P-glycoprotein but not topoisomerase II and glutathione-S-transferase-pi accounts for enhanced intracellular drug-resistance in LoVo MDR human cell lines.", "journal": "Tumori", "date": "1992", "authors": "Boiocchi M, Tumiotto L, Giannini F, Viel A, Biscontin G, Sartor F, Toffoli G", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "1359686", "url": "https://glygen.org/publication/PubMed/1359686" } ] }, { "title": "Identification of the double-stranded RNA-binding domain of the human interferon-inducible protein kinase.", "journal": "The Journal of biological chemistry", "date": "1992-04-15", "authors": "Patel R C, Sen G C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "1373135", "url": "https://glygen.org/publication/PubMed/1373135" } ] }, { "title": "Phosphorylation of the cystic fibrosis transmembrane conductance regulator.", "journal": "The Journal of biological chemistry", "date": "1992", "authors": "Picciotto MR, Cohn JA, Bertuzzi G, Greengard P, Nairn AC", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "1377674", "url": "https://glygen.org/publication/PubMed/1377674" } ] }, { "title": "Calcium ionophore A23187 induces expression of the growth arrest and DNA damage inducible CCAAT/enhancer-binding protein (C/EBP)-related gene, gadd153. Ca2+ increases transcriptional activity and mRNA stability.", "journal": "The Journal of biological chemistry", "date": "1992", "authors": "Bartlett JD, Luethy JD, Carlson SG, Sollott SJ, Holbrook NJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9633012", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9633012" } ], "reference": [ { "type": "PubMed", "id": "1400365", "url": "https://glygen.org/publication/PubMed/1400365" } ] }, { "title": "Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control.", "journal": "Cell", "date": "2003", "authors": "Mazumder B, Sampath P, Seshadri V, Maitra RK, DiCorleto PE, Fox PL", "evidence": [ { "database": "Reactome", "id": "R-HSA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156827" } ], "reference": [ { "type": "PubMed", "id": "14567916", "url": "https://glygen.org/publication/PubMed/14567916" } ] }, { "title": "The carboxy-terminal, M3 motifs of PACT and TRBP have opposite effects on PKR activity.", "journal": "Virology", "date": "2003-10-25", "authors": "Gupta Vishal, Huang Xu, Patel Rekha C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "14585331", "url": "https://glygen.org/publication/PubMed/14585331" } ] }, { "title": "Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Averous J, Bruhat A, Jousse C, Carraro V, Thiel G, Fafournoux P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9633012", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9633012" } ], "reference": [ { "type": "PubMed", "id": "14630918", "url": "https://glygen.org/publication/PubMed/14630918" } ] }, { "title": "Structural determinants of P-glycoprotein-mediated transport of glucocorticoids.", "journal": "Pharmaceutical research", "date": "2003", "authors": "Yates CR, Chang C, Kearbey JD, Yasuda K, Schuetz EG, Miller DD, Dalton JT, Swaan PW", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "14661924", "url": "https://glygen.org/publication/PubMed/14661924" } ] }, { "title": "Pharmacokinetics of erythromycin in rabbit corneas after single-dose infusion: role of P-glycoprotein as a barrier to in vivo ocular drug absorption.", "journal": "The Journal of pharmacology and experimental therapeutics", "date": "2004", "authors": "Dey S, Gunda S, Mitra AK", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "15175422", "url": "https://glygen.org/publication/PubMed/15175422" } ] }, { "title": "Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L.", "journal": "Virology", "date": "2004", "authors": "Langland JO, Jacobs BL", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "reference": [ { "type": "PubMed", "id": "15207627", "url": "https://glygen.org/publication/PubMed/15207627" } ] }, { "title": "Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation.", "journal": "The Journal of biological chemistry", "date": "2004-09-03", "authors": "Silva Arist\u00f3bolo M, Whitmore Mark, Xu Zan, Jiang Zhengfan, Li Xiaoxia, Williams Bryan R G", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "15229216", "url": "https://glygen.org/publication/PubMed/15229216" } ] }, { "title": "The Fanconi anemia proteins functionally interact with the protein kinase regulated by RNA (PKR).", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Zhang X, Li J, Sejas DP, Rathbun KR, Bagby GC, Pang Q", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "15299030", "url": "https://glygen.org/publication/PubMed/15299030" } ] }, { "title": "Activating transcription factor 4 is translationally regulated by hypoxic stress.", "journal": "Molecular and cellular biology", "date": "2004", "authors": "Blais JD, Filipenko V, Bi M, Harding HP, Ron D, Koumenis C, Wouters BG, Bell JC", "evidence": [ { "database": "Reactome", "id": "R-HSA-381042", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381042" } ], "reference": [ { "type": "PubMed", "id": "15314157", "url": "https://glygen.org/publication/PubMed/15314157" } ] }, { "title": "Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B.", "journal": "Structure", "date": "2004", "authors": "Ito Takuhiro, Marintchev Assen, Wagner Gerhard", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "reference": [ { "type": "PubMed", "id": "15341733", "url": "https://glygen.org/publication/PubMed/15341733" } ] }, { "title": "GCN2 phosphorylation of eIF2alpha activates NF-kappaB in response to UV irradiation.", "journal": "The Biochemical journal", "date": "2005", "authors": "Jiang HY, Wek RC", "evidence": [ { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "reference": [ { "type": "PubMed", "id": "15355306", "url": "https://glygen.org/publication/PubMed/15355306" } ] }, { "title": "Amino acid deprivation induces the transcription rate of the human asparagine synthetase gene through a timed program of expression and promoter binding of nutrient-responsive basic region/leucine zipper transcription factors as well as localized histone acetylation.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Chen H, Pan YX, Dudenhausen EE, Kilberg MS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9633012", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9633012" } ], "reference": [ { "type": "PubMed", "id": "15385533", "url": "https://glygen.org/publication/PubMed/15385533" } ] }, { "title": "Identification of budesonide and prednisone as substrates of the intestinal drug efflux pump P-glycoprotein.", "journal": "Inflammatory bowel diseases", "date": "2004", "authors": "Dilger K, Schwab M, Fromm MF", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "15472518", "url": "https://glygen.org/publication/PubMed/15472518" } ] }, { "title": "Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Jiang HY, Wek RC", "evidence": [ { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "reference": [ { "type": "PubMed", "id": "15684420", "url": "https://glygen.org/publication/PubMed/15684420" } ] }, { "title": "Phosphorylation of HIV Tat by PKR increases interaction with TAR RNA and enhances transcription.", "journal": "Virology journal", "date": "2005-02-28", "authors": "Endo-Munoz Liliana, Warby Tammra, Harrich David, McMillan Nigel A J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "15737233", "url": "https://glygen.org/publication/PubMed/15737233" } ] }, { "title": "Identification of the heparin-binding domains of the interferon-induced protein kinase, PKR.", "journal": "The FEBS journal", "date": "2005-03", "authors": "Fasciano Stephen, Hutchins Brian, Handy Indhira, Patel Rekha C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "15752359", "url": "https://glygen.org/publication/PubMed/15752359" } ] }, { "title": "TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death.", "journal": "The EMBO journal", "date": "2005", "authors": "Ohoka N, Yoshii S, Hattori T, Onozaki K, Hayashi H", "evidence": [ { "database": "Reactome", "id": "R-HSA-9633012", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9633012" } ], "reference": [ { "type": "PubMed", "id": "15775988", "url": "https://glygen.org/publication/PubMed/15775988" } ] }, { "title": "Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions.", "journal": "Biochemical and biophysical research communications", "date": "2005", "authors": "Ord D, Ord T", "evidence": [ { "database": "Reactome", "id": "R-HSA-9633012", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9633012" } ], "reference": [ { "type": "PubMed", "id": "15781252", "url": "https://glygen.org/publication/PubMed/15781252" } ] }, { "title": "Selective and ATP-dependent translocation of peptides by the homodimeric ATP binding cassette transporter TAP-like (ABCB9).", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Wolters JC, Abele R, Tampe R", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "15863492", "url": "https://glygen.org/publication/PubMed/15863492" } ] }, { "title": "ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma.", "journal": "Cancer research", "date": "2005", "authors": "Frank NY, Margaryan A, Huang Y, Schatton T, Waaga-Gasser AM, Gasser M, Sayegh MH, Sadee W, Frank MH", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "15899824", "url": "https://glygen.org/publication/PubMed/15899824" } ] }, { "title": "Mechanisms for HIV Tat upregulation of IL-10 and other cytokine expression: kinase signaling and PKR-mediated immune response.", "journal": "FEBS letters", "date": "2005-06-06", "authors": "Li James C B, Lee Davy C W, Cheung Benny K W, Lau Allan S Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "15907845", "url": "https://glygen.org/publication/PubMed/15907845" } ] }, { "title": "Amino-acid limitation induces transcription from the human C/EBPbeta gene via an enhancer activity located downstream of the protein coding sequence.", "journal": "The Biochemical journal", "date": "2005", "authors": "Chen C, Dudenhausen E, Chen H, Pan YX, Gjymishka A, Kilberg MS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9633012", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9633012" } ], "reference": [ { "type": "PubMed", "id": "16026328", "url": "https://glygen.org/publication/PubMed/16026328" } ] }, { "title": "Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR.", "journal": "Cell", "date": "2005", "authors": "Dar AC, Dever TE, Sicheri F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" }, { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "reference": [ { "type": "PubMed", "id": "16179258", "url": "https://glygen.org/publication/PubMed/16179258" } ] }, { "title": "Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition.", "journal": "Cell", "date": "2005", "authors": "Dey M, Cao C, Dar AC, Tamura T, Ozato K, Sicheri F, Dever TE", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" }, { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "reference": [ { "type": "PubMed", "id": "16179259", "url": "https://glygen.org/publication/PubMed/16179259" } ] }, { "title": "Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases.", "journal": "Biochemical and biophysical research communications", "date": "2005", "authors": "Suragani RN, Kamindla R, Ehtesham NZ, Ramaiah KV", "evidence": [ { "database": "Reactome", "id": "R-HSA-381042", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381042" }, { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "reference": [ { "type": "PubMed", "id": "16288713", "url": "https://glygen.org/publication/PubMed/16288713" } ] }, { "title": "An efficient mammalian cell-free translation system supplemented with translation factors.", "journal": "Protein expression and purification", "date": "2006", "authors": "Mikami S, Masutani M, Sonenberg N, Yokoyama S, Imataka H", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "reference": [ { "type": "PubMed", "id": "16289705", "url": "https://glygen.org/publication/PubMed/16289705" } ] }, { "title": "Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2006", "authors": "Su Q, Wang S, Baltzis D, Qu LK, Wong AH, Koromilas AE", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "16373505", "url": "https://glygen.org/publication/PubMed/16373505" } ] }, { "title": "The catalytic activity of the eukaryotic initiation factor-2alpha kinase PKR is required to negatively regulate Stat1 and Stat3 via activation of the T-cell protein-tyrosine phosphatase.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Wang S, Raven JF, Baltzis D, Kazemi S, Brunet DV, Hatzoglou M, Tremblay ML, Koromilas AE", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "16431927", "url": "https://glygen.org/publication/PubMed/16431927" } ] }, { "title": "The N-terminus of PKR is responsible for the activation of the NF-kappaB signaling pathway by interacting with the IKK complex.", "journal": "Cellular signalling", "date": "2006-11", "authors": "Bonnet Marion C, Daurat Caroline, Ottone Catherine, Meurs Eliane F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "16600570", "url": "https://glygen.org/publication/PubMed/16600570" } ] }, { "title": "Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Scheuner D, Patel R, Wang F, Lee K, Kumar K, Wu J, Nilsson A, Karin M, Kaufman RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "16717090", "url": "https://glygen.org/publication/PubMed/16717090" } ] }, { "title": "A synthetic peptide substrate for initiation factor-2 kinases.", "journal": "Biochemical and biophysical research communications", "date": "1991", "authors": "Mellor H, Proud CG", "evidence": [ { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "reference": [ { "type": "PubMed", "id": "1677563", "url": "https://glygen.org/publication/PubMed/1677563" } ] }, { "title": "Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins.", "journal": "Physiological reviews", "date": "2006", "authors": "Deeley RG, Westlake C, Cole SP", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "16816140", "url": "https://glygen.org/publication/PubMed/16816140" } ] }, { "title": "Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator.", "journal": "Cell", "date": "2006", "authors": "Younger JM, Chen L, Ren HY, Rosser MF, Turnbull EL, Fan CY, Patterson C, Cyr DM", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "16901789", "url": "https://glygen.org/publication/PubMed/16901789" } ] }, { "title": "Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon.", "journal": "Cell", "date": "1990-07-27", "authors": "Meurs E, Chong K, Galabru J, Thomas N S, Kerr I M, Williams B R, Hovanessian A G", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "1695551", "url": "https://glygen.org/publication/PubMed/1695551" } ] }, { "title": "Phosphorylation of specific serine residues in the PKR activation domain of PACT is essential for its ability to mediate apoptosis.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Peters GA, Li S, Sen GC", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "16982605", "url": "https://glygen.org/publication/PubMed/16982605" } ] }, { "title": "Activation of the ATF3 gene through a co-ordinated amino acid-sensing response programme that controls transcriptional regulation of responsive genes following amino acid limitation.", "journal": "The Biochemical journal", "date": "2007", "authors": "Pan YX, Chen H, Thiaville MM, Kilberg MS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9633012", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9633012" } ], "reference": [ { "type": "PubMed", "id": "16989641", "url": "https://glygen.org/publication/PubMed/16989641" } ] }, { "title": "Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection.", "journal": "Journal of virology", "date": "2007-01", "authors": "Nie Yongzhan, Hammond Graeme L, Yang Jing-Hua", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "17079286", "url": "https://glygen.org/publication/PubMed/17079286" } ] }, { "title": "Amino acid limitation induces expression of ATF5 mRNA at the post-transcriptional level.", "journal": "Life sciences", "date": "2007", "authors": "Watatani Y, Kimura N, Shimizu YI, Akiyama I, Tonaki D, Hirose H, Takahashi S, Takahashi Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648895", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648895" } ], "reference": [ { "type": "PubMed", "id": "17140605", "url": "https://glygen.org/publication/PubMed/17140605" } ] }, { "title": "Activation of PKR: an open and shut case?", "journal": "Trends in biochemical sciences", "date": "2007-02", "authors": "Cole James L", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "17196820", "url": "https://glygen.org/publication/PubMed/17196820" } ] }, { "title": "ATF2 is required for amino acid-regulated transcription by orchestrating specific histone acetylation.", "journal": "Nucleic acids research", "date": "2007", "authors": "Bruhat A, Cherasse Y, Maurin AC, Breitwieser W, Parry L, Deval C, Jones N, Jousse C, Fafournoux P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9633012", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9633012" } ], "reference": [ { "type": "PubMed", "id": "17267404", "url": "https://glygen.org/publication/PubMed/17267404" } ] }, { "title": "Involvement of ERKs, RSK2 and PKR in UVA-induced signal transduction toward phosphorylation of eIF2alpha (Ser(51)).", "journal": "Carcinogenesis", "date": "2007", "authors": "Zykova TA, Zhu F, Zhang Y, Bode AM, Dong Z", "evidence": [ { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "reference": [ { "type": "PubMed", "id": "17404396", "url": "https://glygen.org/publication/PubMed/17404396" } ] }, { "title": "Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4.", "journal": "Hepatology (Baltimore, Md.)", "date": "2007", "authors": "Morita SY, Kobayashi A, Takanezawa Y, Kioka N, Handa T, Arai H, Matsuo M, Ueda K", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "17523162", "url": "https://glygen.org/publication/PubMed/17523162" } ] }, { "title": "The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP.", "journal": "Nucleic acids research", "date": "2007", "authors": "Cherasse Y, Maurin AC, Chaveroux C, Jousse C, Carraro V, Parry L, Deval C, Chambon C, Fafournoux P, Bruhat A", "evidence": [ { "database": "Reactome", "id": "R-HSA-9633012", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9633012" } ], "reference": [ { "type": "PubMed", "id": "17726049", "url": "https://glygen.org/publication/PubMed/17726049" } ] }, { "title": "A mutation in the ATP-binding site of the Kir6.2 subunit of the KATP channel alters coupling with the SUR2A subunit.", "journal": "The Journal of physiology", "date": "2007", "authors": "Tammaro P, Ashcroft FM", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "17855752", "url": "https://glygen.org/publication/PubMed/17855752" } ] }, { "title": "The N-terminal region of ABC50 interacts with eukaryotic initiation factor eIF2 and is a target for regulatory phosphorylation by CK2.", "journal": "Biochem. J.", "date": "2008", "authors": "Paytubi S, Morrice NA, Boudeau J, Proud CG", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" }, { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "17894550", "url": "https://glygen.org/publication/PubMed/17894550" } ] }, { "title": "PERK in the life and death of the pancreatic beta-cell.", "journal": "Biochemical Society transactions", "date": "2007", "authors": "Herbert TP", "evidence": [ { "database": "Reactome", "id": "R-HSA-381042", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381042" } ], "reference": [ { "type": "PubMed", "id": "17956313", "url": "https://glygen.org/publication/PubMed/17956313" } ] }, { "title": "Identification of a lysosomal peptide transport system induced during dendritic cell development.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Demirel O, Waibler Z, Kalinke U, Grunebach F, Appel S, Brossart P, Hasilik A, Tampe R, Abele R", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "17977821", "url": "https://glygen.org/publication/PubMed/17977821" } ] }, { "title": "Modulation of the eukaryotic initiation factor 2 alpha-subunit kinase PERK by tyrosine phosphorylation.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Su Q, Wang S, Gao HQ, Kazemi S, Harding HP, Ron D, Koromilas AE", "evidence": [ { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "reference": [ { "type": "PubMed", "id": "17998206", "url": "https://glygen.org/publication/PubMed/17998206" } ] }, { "title": "Rotavirus infection induces the phosphorylation of eIF2alpha but prevents the formation of stress granules.", "journal": "Journal of virology", "date": "2008", "authors": "Montero H, Rojas M, Arias CF, Lopez S", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "reference": [ { "type": "PubMed", "id": "18032499", "url": "https://glygen.org/publication/PubMed/18032499" } ] }, { "title": "Stress-induced translation of ATF5 mRNA is regulated by the 5'-untranslated region.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Watatani Y, Ichikawa K, Nakanishi N, Fujimoto M, Takeda H, Kimura N, Hirose H, Takahashi S, Takahashi Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648895", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648895" } ], "reference": [ { "type": "PubMed", "id": "18055463", "url": "https://glygen.org/publication/PubMed/18055463" } ] }, { "title": "Interaction of human tRNA-dihydrouridine synthase-2 with interferon-induced protein kinase PKR.", "journal": "Nucleic acids research", "date": "2008", "authors": "Mittelstadt M, Frump A, Khuu T, Fowlkes V, Handy I, Patel CV, Patel RC", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "18096616", "url": "https://glygen.org/publication/PubMed/18096616" } ] }, { "title": "Inhibition of MDR1 expression by retinol treatment increases sensitivity to etoposide (VP16) in human neoplasic cell line.", "journal": "Toxicology in vitro : an international journal published in association with BIBRA", "date": "2008", "authors": "Klamt F, Passos DT, Castro MA, Gelain DP, Grivicich I, Moreira JC", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "18282684", "url": "https://glygen.org/publication/PubMed/18282684" } ] }, { "title": "HepG2/C3A cells respond to cysteine deprivation by induction of the amino acid deprivation/integrated stress response pathway.", "journal": "Physiological genomics", "date": "2008", "authors": "Lee JI, Dominy JE Jr, Sikalidis AK, Hirschberger LL, Wang W, Stipanuk MH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9633012", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9633012" } ], "reference": [ { "type": "PubMed", "id": "18285520", "url": "https://glygen.org/publication/PubMed/18285520" } ] }, { "title": "Peptide specificity and lipid activation of the lysosomal transport complex ABCB9 (TAPL).", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Zhao C, Haase W, Tampe R, Abele R", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "18434309", "url": "https://glygen.org/publication/PubMed/18434309" } ] }, { "title": "Function of eukaryotic initiation factor 5 in the formation of an 80 S ribosomal polypeptide chain initiation complex.", "journal": "The Journal of biological chemistry", "date": "1991", "authors": "Chakrabarti A, Maitra U", "evidence": [ { "database": "Reactome", "id": "R-HSA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72706" } ], "reference": [ { "type": "PubMed", "id": "1856230", "url": "https://glygen.org/publication/PubMed/1856230" } ] }, { "title": "The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control.", "journal": "Mol. Biol. Cell", "date": "2008", "authors": "Lai MC, Lee YH, Tarn WY", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "reference": [ { "type": "PubMed", "id": "18596238", "url": "https://glygen.org/publication/PubMed/18596238" } ] }, { "title": "Polycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2alpha.", "journal": "Human molecular genetics", "date": "2008", "authors": "Liang G, Yang J, Wang Z, Li Q, Tang Y, Chen XZ", "evidence": [ { "database": "Reactome", "id": "R-HSA-381042", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381042" } ], "reference": [ { "type": "PubMed", "id": "18664456", "url": "https://glygen.org/publication/PubMed/18664456" } ] }, { "title": "Nck-1 interacts with PKR and modulates its activation by dsRNA.", "journal": "Biochemical and biophysical research communications", "date": "2008", "authors": "Cardin E, Larose L", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "18835251", "url": "https://glygen.org/publication/PubMed/18835251" } ] }, { "title": "PKR regulates B56(alpha)-mediated BCL2 phosphatase activity in acute lymphoblastic leukemia-derived REH cells.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Ruvolo VR, Kurinna SM, Karanjeet KB, Schuster TF, Martelli AM, McCubrey JA, Ruvolo PP", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "18957415", "url": "https://glygen.org/publication/PubMed/18957415" } ] }, { "title": "One step at a time: endoplasmic reticulum-associated degradation.", "journal": "Nature reviews. Molecular cell biology", "date": "2008", "authors": "Vembar SS, Brodsky JL", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "19002207", "url": "https://glygen.org/publication/PubMed/19002207" } ] }, { "title": "An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Lee YY, Cevallos RC, Jan E", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "reference": [ { "type": "PubMed", "id": "19131336", "url": "https://glygen.org/publication/PubMed/19131336" } ] }, { "title": "An antiviral response directed by PKR phosphorylation of the RNA helicase A.", "journal": "PLoS pathogens", "date": "2009", "authors": "Sadler AJ, Latchoumanin O, Hawkes D, Mak J, Williams BR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "19229320", "url": "https://glygen.org/publication/PubMed/19229320" } ] }, { "title": "PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2009-05-12", "authors": "Yoon Cheol-Hee, Lee Eun-Soo, Lim Dae-Seog, Bae Yong-Soo", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "19416861", "url": "https://glygen.org/publication/PubMed/19416861" } ] }, { "title": "Influx and efflux transport as determinants of melphalan cytotoxicity: Resistance to melphalan in MDR1 overexpressing tumor cell lines.", "journal": "Biochemical pharmacology", "date": "2009", "authors": "Kuhne A, Tzvetkov MV, Hagos Y, Lage H, Burckhardt G, Brockmoller J", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "19447222", "url": "https://glygen.org/publication/PubMed/19447222" } ] }, { "title": "ABC50 promotes translation initiation in mammalian cells.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Paytubi S, Wang X, Lam YW, Izquierdo L, Hunter MJ, Jan E, Hundal HS, Proud CG", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "19570978", "url": "https://glygen.org/publication/PubMed/19570978" } ] }, { "title": "Lysine acetylation targets protein complexes and co-regulates major cellular functions.", "journal": "Science (New York, N.Y.)", "date": "2009", "authors": "Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "reference": [ { "type": "PubMed", "id": "19608861", "url": "https://glygen.org/publication/PubMed/19608861" } ] }, { "title": "Multidrug resistance phenotype of human BRO melanoma cells transfected with a wild-type human mdr1 complementary DNA.", "journal": "Cancer research", "date": "1990", "authors": "Lincke CR, van der Bliek AM, Schuurhuis GJ, van der Velde-Koerts T, Smit JJ, Borst P", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "1968359", "url": "https://glygen.org/publication/PubMed/1968359" } ] }, { "title": "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.", "journal": "Science signaling", "date": "2009", "authors": "Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" }, { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "reference": [ { "type": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" } ] }, { "title": "RNA-specific adenosine deaminase ADAR1 suppresses measles virus-induced apoptosis and activation of protein kinase PKR.", "journal": "The Journal of biological chemistry", "date": "2009-10-23", "authors": "Toth Ann M, Li Zhiqun, Cattaneo Roberto, Samuel Charles E", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "19710021", "url": "https://glygen.org/publication/PubMed/19710021" } ] }, { "title": "Adenosine deaminase ADAR1 increases gene expression at the translational level by decreasing protein kinase PKR-dependent eIF-2alpha phosphorylation.", "journal": "Journal of molecular biology", "date": "2009-11-06", "authors": "Wang Ying, Samuel Charles E", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "19733181", "url": "https://glygen.org/publication/PubMed/19733181" } ] }, { "title": "Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signaling.", "journal": "Cell", "date": "2009-10-02", "authors": "Paroo Zain, Ye Xuecheng, Chen She, Liu Qinghua", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "19804757", "url": "https://glygen.org/publication/PubMed/19804757" } ] }, { "title": "PKR is not a universal target of tumor suppressor p53 in response to genotoxic stress.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2009-11-01", "authors": "Rahman Mashrur, Lem Christopher, Muaddi Hala, Koromilas Antonis E", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "19838063", "url": "https://glygen.org/publication/PubMed/19838063" } ] }, { "title": "MDR1 polymorphism role in patients treated with cetuximab and irinotecan in irinotecan refractory colorectal cancer.", "journal": "Medical oncology (Northwood, London, England)", "date": "2010", "authors": "Paule B, Castagne V, Picard V, Saffroy R, Adam R, Guettier C, Farinotti R, Bonhomme-Faivre L", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "19862647", "url": "https://glygen.org/publication/PubMed/19862647" } ] }, { "title": "A mutation in the second nucleotide binding fold of the cystic fibrosis gene.", "journal": "American journal of human genetics", "date": "1991", "authors": "Osborne L, Knight R, Santis G, Hodson M", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "1998343", "url": "https://glygen.org/publication/PubMed/1998343" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Gene expression and integrated stress response in HepG2/C3A cells cultured in amino acid deficient medium.", "journal": "Amino acids", "date": "2011", "authors": "Sikalidis AK, Lee JI, Stipanuk MH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9633012", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9633012" } ], "reference": [ { "type": "PubMed", "id": "20361218", "url": "https://glygen.org/publication/PubMed/20361218" } ] }, { "title": "New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses.", "journal": "EMBO reports", "date": "2010", "authors": "Yoon CH, Miah MA, Kim KP, Bae YS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "20395957", "url": "https://glygen.org/publication/PubMed/20395957" } ] }, { "title": "Identification and characterization of the promoter of human ATF5 gene.", "journal": "Journal of biochemistry", "date": "2010", "authors": "Wei Y, Ge Y, Zhou F, Chen H, Cui C, Liu D, Yang Z, Wu G, Gu J, Jiang J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648895", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648895" } ], "reference": [ { "type": "PubMed", "id": "20423929", "url": "https://glygen.org/publication/PubMed/20423929" } ] }, { "title": "Respiratory syncytial virus limits alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) phosphorylation to maintain translation and viral replication.", "journal": "The Journal of biological chemistry", "date": "2010-07-30", "authors": "Groskreutz Dayna J, Babor Ellen C, Monick Martha M, Varga Steven M, Hunninghake Gary W", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "20519500", "url": "https://glygen.org/publication/PubMed/20519500" } ] }, { "title": "P-glycoprotein, but not multidrug resistance protein 4, plays a role in the systemic clearance of irinotecan and SN-38 in mice.", "journal": "Drug metabolism letters", "date": "2010", "authors": "Tagen M, Zhuang Y, Zhang F, Harstead KE, Shen J, Schaiquevich P, Fraga CH, Panetta JC, Waters CM, Stewart CF", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "20583968", "url": "https://glygen.org/publication/PubMed/20583968" } ] }, { "title": "Differences in assessment of macrolide interaction with human MDR1 (ABCB1, P-gp) using rhodamine-123 efflux, ATPase activity and cellular accumulation assays.", "journal": "European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences", "date": "2010", "authors": "Munic V, Kelneric Z, Mikac L, Erakovic Haber V", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "20621639", "url": "https://glygen.org/publication/PubMed/20621639" } ] }, { "title": "The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells.", "journal": "Molecular biology of the cell", "date": "2010", "authors": "Yang X, Nath A, Opperman MJ, Chan C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "20685959", "url": "https://glygen.org/publication/PubMed/20685959" } ] }, { "title": "Multiple forms of PKR present in the nuclei of acute leukemia cells represent an active kinase that is responsive to stress.", "journal": "Leukemia", "date": "2011", "authors": "Blalock WL, Bavelloni A, Piazzi M, Tagliavini F, Faenza I, Martelli AM, Follo MY, Cocco L", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "21072047", "url": "https://glygen.org/publication/PubMed/21072047" } ] }, { "title": "Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense.", "journal": "Genes & development", "date": "2010", "authors": "Harashima A, Guettouche T, Barber GN", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "21123651", "url": "https://glygen.org/publication/PubMed/21123651" } ] }, { "title": "Two phosphorylation sites on eIF-2 alpha.", "journal": "FEBS letters", "date": "1990", "authors": "Kramer G", "evidence": [ { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "reference": [ { "type": "PubMed", "id": "2116318", "url": "https://glygen.org/publication/PubMed/2116318" } ] }, { "title": "Multiple levels of PKR inhibition during HIV-1 replication.", "journal": "Reviews in medical virology", "date": "2011-01", "authors": "Clerzius Guerline, G\u00e9linas Jean-Fran\u00e7ois, Gatignol Anne", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "21294215", "url": "https://glygen.org/publication/PubMed/21294215" } ] }, { "title": "Precursor miR-886, a novel noncoding RNA repressed in cancer, associates with PKR and modulates its activity.", "journal": "RNA (New York, N.Y.)", "date": "2011-06", "authors": "Lee Kwanbok, Kunkeaw Nawapol, Jeon Sung Ho, Lee Inhan, Johnson Betty H, Kang Gum-Yong, Bang Joo Young, Park Hyung Soon, Leelayuwat Chanvit, Lee Yong Sun", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "21518807", "url": "https://glygen.org/publication/PubMed/21518807" } ] }, { "title": "Inhibition of RNase L and RNA-dependent protein kinase (PKR) by sunitinib impairs antiviral innate immunity.", "journal": "The Journal of biological chemistry", "date": "2011-07-29", "authors": "Jha Babal Kant, Polyakova Irina, Kessler Patricia, Dong Beihua, Dickerman Benjamin, Sen Ganes C, Silverman Robert H", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "21636578", "url": "https://glygen.org/publication/PubMed/21636578" } ] }, { "title": "The cellular TAR RNA binding protein, TRBP, promotes HIV-1 replication primarily by inhibiting the activation of double-stranded RNA-dependent kinase PKR.", "journal": "Journal of virology", "date": "2011-12", "authors": "Sanghvi Viraj R, Steel Laura F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "21937648", "url": "https://glygen.org/publication/PubMed/21937648" } ] }, { "title": "Heparin activates PKR by inducing dimerization.", "journal": "Journal of molecular biology", "date": "2011-11-11", "authors": "Anderson Eric, Pierre-Louis Willythssa S, Wong C Jason, Lary Jeffrey W, Cole James L", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "21978664", "url": "https://glygen.org/publication/PubMed/21978664" } ] }, { "title": "Activation of the Antiviral Kinase PKR and Viral Countermeasures.", "journal": "Viruses", "date": "2009-12", "authors": "Dauber Bianca, Wolff Thorsten", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "21994559", "url": "https://glygen.org/publication/PubMed/21994559" } ] }, { "title": "CFTR and TMEM16A are separate but functionally related Cl- channels.", "journal": "Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology", "date": "2011", "authors": "Ousingsawat J, Kongsuphol P, Schreiber R, Kunzelmann K", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "22178883", "url": "https://glygen.org/publication/PubMed/22178883" } ] }, { "title": "The RAX/PACT-PKR stress response pathway promotes p53 sumoylation and activation, leading to G(1) arrest.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2012", "authors": "Bennett RL, Pan Y, Christian J, Hui T, May WS Jr", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "22214662", "url": "https://glygen.org/publication/PubMed/22214662" } ] }, { "title": "Tat-responsive region RNA of human immunodeficiency virus 1 can prevent activation of the double-stranded-RNA-activated protein kinase.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1990-11", "authors": "Gunnery S, Rice A P, Robertson H D, Mathews M B", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "2247437", "url": "https://glygen.org/publication/PubMed/2247437" } ] }, { "title": "Characterization of the direct physical interaction of nc886, a cellular non-coding RNA, and PKR.", "journal": "FEBS letters", "date": "2012-09-21", "authors": "Jeon Sung Ho, Lee Kwanbok, Lee Kwang Soo, Kunkeaw Nawapol, Johnson Betty H, Holthauzen Luis Marcelo F, Gong Bin, Leelayuwat Chanvit, Lee Yong Sun", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "22986343", "url": "https://glygen.org/publication/PubMed/22986343" } ] }, { "title": "Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo.", "journal": "Biochemical pharmacology", "date": "2013", "authors": "Hill CR, Jamieson D, Thomas HD, Brown CD, Boddy AV, Veal GJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "23063411", "url": "https://glygen.org/publication/PubMed/23063411" } ] }, { "title": "eIF2gamma mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation.", "journal": "Mol. Cell", "date": "2012", "authors": "Borck G, Shin BS, Stiller B, Mimouni-Bloch A, Thiele H, Kim JR, Thakur M, Skinner C, Aschenbach L, Smirin-Yosef P, Har-Zahav A, Nurnberg G, Altmuller J, Frommolt P, Hofmann K, Konen O, Nurnberg P, Munnich A, Schwartz CE, Gothelf D, Colleaux L, Dever TE, Kubisch C, Basel-Vanagaite L", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "reference": [ { "type": "PubMed", "id": "23063529", "url": "https://glygen.org/publication/PubMed/23063529" } ] }, { "title": "Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity.", "journal": "Molecular cell", "date": "2012-12-14", "authors": "Shen Shensi, Niso-Santano Mireia, Adjemian Sandy, Takehara Tetsuo, Malik Shoaib Ahmad, Minoux Herv\u00e9, Souquere Sylvie, Mari\u00f1o Guillermo, Lachkar Sylvie, Senovilla Laura, Galluzzi Lorenzo, Kepp Oliver, Pierron G\u00e9rard, Maiuri Maria Chiara, Hikita Hayato, Kroemer Romano, Kroemer Guido", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "23084476", "url": "https://glygen.org/publication/PubMed/23084476" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" }, { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "Activation of double-stranded RNA-activated protein kinase (PKR) by interferon-stimulated gene 15 (ISG15) modification down-regulates protein translation.", "journal": "The Journal of biological chemistry", "date": "2013-01-25", "authors": "Okumura Fumihiko, Okumura Akiko J, Uematsu Keiji, Hatakeyama Shigetsugu, Zhang Dong-Er, Kamura Takumi", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "23229543", "url": "https://glygen.org/publication/PubMed/23229543" } ] }, { "title": "Elevated cJUN expression and an ATF/CRE site within the ATF3 promoter contribute to activation of ATF3 transcription by the amino acid response.", "journal": "Physiological genomics", "date": "2013", "authors": "Fu L, Kilberg MS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9633012", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9633012" } ], "reference": [ { "type": "PubMed", "id": "23269699", "url": "https://glygen.org/publication/PubMed/23269699" } ] }, { "title": "Suppression of antiviral innate immunity by sunitinib enhances oncolytic virotherapy.", "journal": "Molecular therapy : the journal of the American Society of Gene Therapy", "date": "2013-09", "authors": "Jha Babal K, Dong Beihua, Nguyen Carvell T, Polyakova Irina, Silverman Robert H", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "23732991", "url": "https://glygen.org/publication/PubMed/23732991" } ] }, { "title": "The 5'-untranslated region regulates ATF5 mRNA stability via nonsense-mediated mRNA decay in response to environmental stress.", "journal": "The FEBS journal", "date": "2013", "authors": "Hatano M, Umemura M, Kimura N, Yamazaki T, Takeda H, Nakano H, Takahashi S, Takahashi Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648895", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648895" } ], "reference": [ { "type": "PubMed", "id": "23876217", "url": "https://glygen.org/publication/PubMed/23876217" } ] }, { "title": "RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR).", "journal": "The Journal of biological chemistry", "date": "2013", "authors": "El Khouri E, Le Pavec G, Toledano MB, Delaunay-Moisan A", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "24019521", "url": "https://glygen.org/publication/PubMed/24019521" } ] }, { "title": "N-linked glycosylation enrichment for in-depth cell surface proteomics of diffuse large B-cell lymphoma subtypes.", "journal": "Molecular & cellular proteomics : MCP", "date": "2014", "authors": "Deeb SJ, Cox J, Schmidt-Supprian M, Mann M", "evidence": [ { "database": "GlyGen", "id": "GLY_000143", "url": "https://data.glygen.org/GLY_000143" } ], "reference": [ { "type": "PubMed", "id": "24190977", "url": "https://glygen.org/publication/PubMed/24190977" } ] }, { "title": "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.", "journal": "Journal of proteomics", "date": "2014", "authors": "Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" }, { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "reference": [ { "type": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" } ] }, { "title": "Identification of the PKR nuclear interactome reveals roles in ribosome biogenesis, mRNA processing and cell division.", "journal": "Journal of cellular physiology", "date": "2014-08", "authors": "Blalock William L, Piazzi Manuela, Bavelloni Alberto, Raffini Mirco, Faenza Irene, D'Angelo Antonietta, Cocco Lucio", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "24347309", "url": "https://glygen.org/publication/PubMed/24347309" } ] }, { "title": "NF90 exerts antiviral activity through regulation of PKR phosphorylation and stress granules in infected cells.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2014-04-15", "authors": "Wen Xi, Huang Xiaofeng, Mok Bobo Wing-Yee, Chen Yixin, Zheng Min, Lau Siu-Ying, Wang Pui, Song Wenjun, Jin Dong-Yan, Yuen Kwok-Yung, Chen Honglin", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "24623135", "url": "https://glygen.org/publication/PubMed/24623135" } ] }, { "title": "IPS-1 plays an essential role in dsRNA-induced stress granule formation by interacting with PKR and promoting its activation.", "journal": "Journal of cell science", "date": "2014-06-01", "authors": "Zhang Peifen, Li Yuye, Xia Jun, He Junfang, Pu Jieying, Xie Jiong, Wu Siyu, Feng Lianqiang, Huang Xi, Zhang Ping", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "24659800", "url": "https://glygen.org/publication/PubMed/24659800" } ] }, { "title": "Biosynthesis of cystic fibrosis transmembrane conductance regulator.", "journal": "The international journal of biochemistry & cell biology", "date": "2014", "authors": "Pranke IM, Sermet-Gaudelus I", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "24685677", "url": "https://glygen.org/publication/PubMed/24685677" } ] }, { "title": "A bimodular nuclear localization signal assembled via an extended double-stranded RNA-binding domain acts as an RNA-sensing signal for transportin 1.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2014", "authors": "Barraud P, Banerjee S, Mohamed WI, Jantsch MF, Allain FH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "24753571", "url": "https://glygen.org/publication/PubMed/24753571" } ] }, { "title": "Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA.", "journal": "Science (New York, N.Y.)", "date": "1989", "authors": "Riordan JR, Rommens JM, Kerem B, Alon N, Rozmahel R, Grzelczak Z, Zielenski J, Lok S, Plavsic N, Chou JL, et al.", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "2475911", "url": "https://glygen.org/publication/PubMed/2475911" } ] }, { "title": "Mechanism of the nucleotide exchange reaction in eukaryotic polypeptide chain initiation. Characterization of the guanine nucleotide exchange factor as a GTP-binding protein.", "journal": "The Journal of biological chemistry", "date": "1989", "authors": "Dholakia JN, Wahba AJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-72731", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72731" } ], "reference": [ { "type": "PubMed", "id": "2491852", "url": "https://glygen.org/publication/PubMed/2491852" } ] }, { "title": "Molecular mechanisms for biliary phospholipid and drug efflux mediated by ABCB4 and bile salts.", "journal": "BioMed research international", "date": "2014", "authors": "Morita SY, Terada T", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "25133187", "url": "https://glygen.org/publication/PubMed/25133187" } ] }, { "title": "p53-derived host restriction of HIV-1 replication by protein kinase R-mediated Tat phosphorylation and inactivation.", "journal": "Journal of virology", "date": "2015-04", "authors": "Yoon Cheol-Hee, Kim Sang-Yoon, Byeon Se Eun, Jeong Yideul, Lee Jinjoo, Kim Kwang Pyo, Park Jinseu, Bae Yong-Soo", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "25653431", "url": "https://glygen.org/publication/PubMed/25653431" } ] }, { "title": "Rheb Inhibits Protein Synthesis by Activating the PERK-eIF2\u03b1 Signaling Cascade.", "journal": "Cell reports", "date": "2015-02-10", "authors": "Tyagi Richa, Shahani Neelam, Gorgen Lindsay, Ferretti Max, Pryor William, Chen Po Yu, Swarnkar Supriya, Worley Paul F, Karbstein Katrin, Snyder Solomon H, Subramaniam Srinivasa", "evidence": [ { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "reference": [ { "type": "PubMed", "id": "25660019", "url": "https://glygen.org/publication/PubMed/25660019" } ] }, { "title": "Transepithelial transport of drugs by the multidrug transporter in cultured Madin-Darby canine kidney cell epithelia.", "journal": "The Journal of biological chemistry", "date": "1989", "authors": "Horio M, Chin KV, Currier SJ, Goldenberg S, Williams C, Pastan I, Gottesman MM, Handler J", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "2570070", "url": "https://glygen.org/publication/PubMed/2570070" } ] }, { "title": "Potential role for snoRNAs in PKR activation during metabolic stress.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2015-04-21", "authors": "Youssef Osama A, Safran Sarah A, Nakamura Takahisa, Nix David A, Hotamisligil G\u00f6khan S, Bass Brenda L", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "25848059", "url": "https://glygen.org/publication/PubMed/25848059" } ] }, { "title": "Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element.", "journal": "The Journal of biological chemistry", "date": "2015", "authors": "Crawford RR, Prescott ET, Sylvester CF, Higdon AN, Shan J, Kilberg MS, Mungrue IN", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648895", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648895" } ], "reference": [ { "type": "PubMed", "id": "25931127", "url": "https://glygen.org/publication/PubMed/25931127" } ] }, { "title": "O-GlcNAcylation of eIF2alpha regulates the phospho-eIF2alpha-mediated ER stress response.", "journal": "Biochimica et biophysica acta", "date": "2015", "authors": "Jang I, Kim HB, Seo H, Kim JY, Choi H, Yoo JS, Kim JW, Cho JW", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05198", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05198" }, { "database": "O-GlcNAc Atlas", "id": "P05198", "url": "https://oglcnac.org/atlas/detail/P05198" } ], "reference": [ { "type": "PubMed", "id": "25937070", "url": "https://glygen.org/publication/PubMed/25937070" } ] }, { "title": "Temozolomide competes for P-glycoprotein and contributes to chemoresistance in glioblastoma cells.", "journal": "Cancer letters", "date": "2015", "authors": "Munoz JL, Walker ND, Scotto KW, Rameshwar P", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "26208431", "url": "https://glygen.org/publication/PubMed/26208431" } ] }, { "title": "The Regulatory and Kinase Domains but Not the Interdomain Linker Determine Human Double-stranded RNA-activated Kinase (PKR) Sensitivity to Inhibition by Viral Non-coding RNAs.", "journal": "The Journal of biological chemistry", "date": "2015-11-20", "authors": "Sunita S, Schwartz Samantha L, Conn Graeme L", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "26432638", "url": "https://glygen.org/publication/PubMed/26432638" } ] }, { "title": "Activated PKR inhibits pancreatic \u03b2-cell proliferation through sumoylation-dependent stabilization of P53.", "journal": "Molecular immunology", "date": "2015-12", "authors": "Song Ying, Wan XiaoMeng, Gao LiLi, Pan Yi, Xie WeiPing, Wang Hong, Guo Jun", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "26446704", "url": "https://glygen.org/publication/PubMed/26446704" } ] }, { "title": "Regulation of PKR by RNA: formation of active and inactive dimers.", "journal": "Biochemistry", "date": "2015-11-10", "authors": "Husain Bushra, Hesler Stephen, Cole James L", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "26488609", "url": "https://glygen.org/publication/PubMed/26488609" } ] }, { "title": "Essential role of protein kinase R antagonism by TRS1 in human cytomegalovirus replication.", "journal": "Virology", "date": "2016-02", "authors": "Braggin Jacquelyn E, Child Stephanie J, Geballe Adam P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "26716879", "url": "https://glygen.org/publication/PubMed/26716879" } ] }, { "title": "Editing of Cellular Self-RNAs by Adenosine Deaminase ADAR1 Suppresses Innate Immune Stress Responses.", "journal": "The Journal of biological chemistry", "date": "2016-03-18", "authors": "George Cyril X, Ramaswami Gokul, Li Jin Billy, Samuel Charles E", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "26817845", "url": "https://glygen.org/publication/PubMed/26817845" } ] }, { "title": "Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress.", "journal": "Cell reports", "date": "2016", "authors": "Rainbolt TK, Lebeau J, Puchades C, Wiseman RL", "evidence": [ { "database": "Reactome", "id": "R-HSA-9840373", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9840373" } ], "reference": [ { "type": "PubMed", "id": "26923599", "url": "https://glygen.org/publication/PubMed/26923599" } ] }, { "title": "Activation of PKR by short stem-loop RNAs containing single-stranded arms.", "journal": "RNA (New York, N.Y.)", "date": "2016-07", "authors": "Mayo Christopher B, Wong C Jason, Lopez Prisma E, Lary Jeffrey W, Cole James L", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "27208315", "url": "https://glygen.org/publication/PubMed/27208315" } ] }, { "title": "Discriminating Self and Non-Self by RNA: Roles for RNA Structure, Misfolding, and Modification in Regulating the Innate Immune Sensor PKR.", "journal": "Accounts of chemical research", "date": "2016-06-21", "authors": "Hull Chelsea M, Bevilacqua Philip C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "27269119", "url": "https://glygen.org/publication/PubMed/27269119" } ] }, { "title": "NF90 is a novel influenza A virus NS1-interacting protein that antagonizes the inhibitory role of NS1 on PKR phosphorylation.", "journal": "FEBS letters", "date": "2016-08", "authors": "Li Ting, Li Xi, Zhu WenFei, Wang HuiYu, Mei Lin, Wu ShaoQiang, Lin XiangMei, Han XueQing", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "27423063", "url": "https://glygen.org/publication/PubMed/27423063" } ] }, { "title": "TRIB3 increases cell resistance to arsenite toxicity by limiting the expression of the glutathione-degrading enzyme CHAC1.", "journal": "Biochimica et biophysica acta", "date": "2016", "authors": "Ord D, Ord T, Biene T, Ord T", "evidence": [ { "database": "Reactome", "id": "R-HSA-9633012", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9633012" } ], "reference": [ { "type": "PubMed", "id": "27526673", "url": "https://glygen.org/publication/PubMed/27526673" } ] }, { "title": "Mechanism of Protein Kinase R Inhibition by Human Cytomegalovirus pTRS1.", "journal": "Journal of virology", "date": "2017", "authors": "Vincent HA, Ziehr B, Moorman NJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "27974558", "url": "https://glygen.org/publication/PubMed/27974558" } ] }, { "title": "Human noncoding RNA 886 (nc886) adopts two structurally distinct conformers that are functionally opposing regulators of PKR.", "journal": "RNA (New York, N.Y.)", "date": "2017-04", "authors": "Calderon Brenda M, Conn Graeme L", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "28069888", "url": "https://glygen.org/publication/PubMed/28069888" } ] }, { "title": "Polymorphisms in the multidrug-resistance 1 gene related to glucocorticoid response in rheumatoid arthritis treatment.", "journal": "Rheumatology international", "date": "2017", "authors": "Cuppen BV, Pardali K, Kraan MC, Marijnissen AC, Yrlid L, Olsson M, Bijlsma JW, Lafeber FP, Fritsch-Stork RD", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "28132103", "url": "https://glygen.org/publication/PubMed/28132103" } ] }, { "title": "ADAR1 and PACT contribute to efficient translation of transcripts containing HIV-1 trans-activating response (TAR) element.", "journal": "The Biochemical journal", "date": "2017", "authors": "Chukwurah E, Handy I, Patel RC", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "28167698", "url": "https://glygen.org/publication/PubMed/28167698" } ] }, { "title": "Auto-phosphorylation Represses Protein Kinase R Activity.", "journal": "Scientific reports", "date": "2017-03-10", "authors": "Wang Die, de Weerd Nicole A, Willard Belinda, Polekhina Galina, Williams Bryan R G, Sadler Anthony J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "28281686", "url": "https://glygen.org/publication/PubMed/28281686" } ] }, { "title": "Quantitative proteomics identifies altered O-GlcNAcylation of structural, synaptic and memory-associated proteins in Alzheimer's disease.", "journal": "The Journal of pathology", "date": "2017", "authors": "Wang S, Yang F, Petyuk VA, Shukla AK, Monroe ME, Gritsenko MA, Rodland KD, Smith RD, Qian WJ, Gong CX, Liu T", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05198", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05198" }, { "database": "O-GlcNAc Atlas", "id": "P05198", "url": "https://oglcnac.org/atlas/detail/P05198" } ], "reference": [ { "type": "PubMed", "id": "28657654", "url": "https://glygen.org/publication/PubMed/28657654" } ] }, { "title": "Non-coding RNA 886 promotes renal cell carcinoma growth and metastasis through the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway.", "journal": "Molecular medicine reports", "date": "2017-10", "authors": "Lei Jun, Xiao Ju-Hua, Zhang Shou-Hua, Liu Zhi-Qiang, Huang Kai, Luo Zhi-Peng, Xiao Xin-Lan, Hong Zheng-Dong", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "28765891", "url": "https://glygen.org/publication/PubMed/28765891" } ] }, { "title": "Elucidation of molecular mechanism of stability of the heme-regulated eIF2alpha kinase upon binding of its ligand, hemin in its catalytic kinase domain.", "journal": "Journal of biomolecular structure & dynamics", "date": "2018", "authors": "Bhavnani V, Kaviraj S, Panigrahi P, Suresh CG, Yapara S, Pal J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648895", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648895" } ], "reference": [ { "type": "PubMed", "id": "28814160", "url": "https://glygen.org/publication/PubMed/28814160" } ] }, { "title": "A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1988", "authors": "Pastan I, Gottesman MM, Ueda K, Lovelace E, Rutherford AV, Willingham MC", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "2898143", "url": "https://glygen.org/publication/PubMed/2898143" } ] }, { "title": "Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT.", "journal": "Scientific reports", "date": "2017-11-23", "authors": "Dabo Stephanie, Maillard Patrick, Collados Rodriguez Milagros, Hansen Marianne Dor\u00e9, Mazouz Sabrina, Bigot Donna-Joe, Tible Marion, Janvier Genevi\u00e8ve, Helynck Olivier, Cassonnet Patricia, Jacob Yves, Bellalou Jacques, Gatignol Anne, Patel Rekha C, Hugon Jacques, Munier-Lehmann H\u00e9l\u00e8ne, Meurs Eliane F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "29170442", "url": "https://glygen.org/publication/PubMed/29170442" } ] }, { "title": "PPP2R5A: A multirole protein phosphatase subunit in regulating cancer development.", "journal": "Cancer letters", "date": "2018", "authors": "Mao Z, Liu C, Lin X, Sun B, Su C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "29175459", "url": "https://glygen.org/publication/PubMed/29175459" } ] }, { "title": "Contribution of the two dsRBM motifs to the double-stranded RNA binding and protein interactions of PACT.", "journal": "Journal of cellular biochemistry", "date": "2018-04", "authors": "Chukwurah Evelyn, Willingham Victoria, Singh Madhurima, Castillo-Azofeifa David, Patel Rekha C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "29231267", "url": "https://glygen.org/publication/PubMed/29231267" } ] }, { "title": "Stress-induced TRBP phosphorylation enhances its interaction with PKR to regulate cellular survival.", "journal": "Scientific reports", "date": "2018", "authors": "Chukwurah E, Patel RC", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "29348664", "url": "https://glygen.org/publication/PubMed/29348664" } ] }, { "title": "Nc886 is epigenetically repressed in prostate cancer and acts as a tumor suppressor through the inhibition of cell growth.", "journal": "BMC cancer", "date": "2018-02-02", "authors": "Fort Rafael Sebasti\u00e1n, Math\u00f3 Cecilia, Geraldo Murilo Vieira, Ottati Mar\u00eda Carolina, Yamashita Alex Shimura, Saito Kelly Cristina, Leite Katia Ramos Moreira, M\u00e9ndez Manuel, Maedo Noem\u00ed, M\u00e9ndez Laura, Garat Beatriz, Kimura Edna Teruko, Sotelo-Silveira Jos\u00e9 Roberto, Duhagon Mar\u00eda Ana", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "29394925", "url": "https://glygen.org/publication/PubMed/29394925" } ] }, { "title": "Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown.", "journal": "Cell", "date": "2018-02-08", "authors": "Chung Hachung, Calis Jorg J A, Wu Xianfang, Sun Tony, Yu Yingpu, Sarbanes Stephanie L, Dao Thi Viet Loan, Shilvock Abigail R, Hoffmann H-Heinrich, Rosenberg Brad R, Rice Charles M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "29395325", "url": "https://glygen.org/publication/PubMed/29395325" } ] }, { "title": "Regulation of the ATF3 gene by a single promoter in response to amino acid availability and endoplasmic reticulum stress in human primary hepatocytes and hepatoma cells.", "journal": "Biochimica et biophysica acta. Gene regulatory mechanisms", "date": "2018", "authors": "Hayner JN, Shan J, Kilberg MS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9633012", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9633012" } ], "reference": [ { "type": "PubMed", "id": "29413899", "url": "https://glygen.org/publication/PubMed/29413899" } ] }, { "title": "Role of eIF2\u03b1 Kinases in Translational Control and Adaptation to Cellular Stress.", "journal": "Cold Spring Harbor perspectives in biology", "date": "2018-07-02", "authors": "Wek Ronald C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "29440070", "url": "https://glygen.org/publication/PubMed/29440070" } ] }, { "title": "Cloning and sequencing of complementary DNAs encoding the alpha-subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA.", "journal": "J. Biol. Chem.", "date": "1987", "authors": "Ernst H, Duncan RF, Hershey JW", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "reference": [ { "type": "PubMed", "id": "2948954", "url": "https://glygen.org/publication/PubMed/2948954" } ] }, { "title": "Inflammation kinase PKR phosphorylates \u03b1-synuclein and causes \u03b1-synuclein-dependent cell death.", "journal": "Neurobiology of disease", "date": "2018-07", "authors": "Reimer Lasse, Vesterager Louise Buur, Betzer Cristine, Zheng Jin, Nielsen L\u00e6rke Dalsgaard, Kofoed Rikke Hahn, Lassen Louise Berkhoudt, B\u00f8lcho Ulrik, Paludan S\u00f8ren Riis, Fog Karina, Jensen Poul Henning", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "29501855", "url": "https://glygen.org/publication/PubMed/29501855" } ] }, { "title": "PKR Senses Nuclear and Mitochondrial Signals by Interacting with Endogenous Double-Stranded RNAs.", "journal": "Molecular cell", "date": "2018-09-20", "authors": "Kim Yoosik, Park Joha, Kim Sujin, Kim MinA, Kang Myeong-Gyun, Kwak Chulhwan, Kang Minjeong, Kim Baekgyu, Rhee Hyun-Woo, Kim V Narry", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "30174290", "url": "https://glygen.org/publication/PubMed/30174290" } ] }, { "title": "Eukaryotic Initiation Factor 5B (eIF5B) Cooperates with eIF1A and eIF5 to Facilitate uORF2-Mediated Repression of ATF4 Translation.", "journal": "International journal of molecular sciences", "date": "2018", "authors": "Ross JA, Bressler KR, Thakor N", "evidence": [ { "database": "Reactome", "id": "R-HSA-381042", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381042" } ], "reference": [ { "type": "PubMed", "id": "30551605", "url": "https://glygen.org/publication/PubMed/30551605" } ] }, { "title": "The search for a PKR code-differential regulation of protein kinase R activity by diverse RNA and protein regulators.", "journal": "RNA (New York, N.Y.)", "date": "2019", "authors": "Bou-Nader C, Gordon JM, Henderson FE, Zhang J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "30770398", "url": "https://glygen.org/publication/PubMed/30770398" } ] }, { "title": "Activation of GCN2 by the ribosomal P-stalk.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2019", "authors": "Inglis AJ, Masson GR, Shao S, Perisic O, McLaughlin SH, Hegde RS, Williams RL", "evidence": [ { "database": "Reactome", "id": "R-HSA-9633012", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9633012" } ], "reference": [ { "type": "PubMed", "id": "30804176", "url": "https://glygen.org/publication/PubMed/30804176" } ] }, { "title": "Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity.", "journal": "Cell", "date": "2019-05-02", "authors": "Liu Chu-Xiao, Li Xiang, Nan Fang, Jiang Shan, Gao Xiang, Guo Si-Kun, Xue Wei, Cui Yange, Dong Kaige, Ding Huihua, Qu Bo, Zhou Zhaocai, Shen Nan, Yang Li, Chen Ling-Ling", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "31031002", "url": "https://glygen.org/publication/PubMed/31031002" } ] }, { "title": "Structural basis for eIF2B inhibition in integrated stress response.", "journal": "Science (New York, N.Y.)", "date": "2019-05-03", "authors": "Kashiwagi Kazuhiro, Yokoyama Takeshi, Nishimoto Madoka, Takahashi Mari, Sakamoto Ayako, Yonemochi Mayumi, Shirouzu Mikako, Ito Takuhiro", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "reference": [ { "type": "PubMed", "id": "31048492", "url": "https://glygen.org/publication/PubMed/31048492" } ] }, { "title": "Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB.", "journal": "Mol. Cell", "date": "2020", "authors": "Young-Baird Sara K, Louren\u00e7o Ma\u00edra Bertolessi, Elder Megan K, Klann Eric, Liebau Stefan, Dever Thomas E", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "reference": [ { "type": "PubMed", "id": "31836389", "url": "https://glygen.org/publication/PubMed/31836389" } ] }, { "title": "vtRNA2-1/nc886 Produces a Small RNA That Contributes to Its Tumor Suppression Action through the microRNA Pathway in Prostate Cancer.", "journal": "Non-coding RNA", "date": "2020-02-20", "authors": "Fort Rafael Sebasti\u00e1n, Garat Beatriz, Sotelo-Silveira Jos\u00e9 Roberto, Duhagon Mar\u00eda Ana", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "32093270", "url": "https://glygen.org/publication/PubMed/32093270" } ] }, { "title": "Engineering a Proximity-Directed O-GlcNAc Transferase for Selective Protein O-GlcNAcylation in Cells.", "journal": "ACS chemical biology", "date": "2020", "authors": "Ramirez DH, Aonbangkhen C, Wu HY, Naftaly JA, Tang S, O'Meara TR, Woo CM", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05198", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05198" } ], "reference": [ { "type": "PubMed", "id": "32119511", "url": "https://glygen.org/publication/PubMed/32119511" } ] }, { "title": "A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.", "journal": "Nature", "date": "2020", "authors": "Fessler E, Eckl EM, Schmitt S, Mancilla IA, Meyer-Bender MF, Hanf M, Philippou-Massier J, Krebs S, Zischka H, Jae LT", "evidence": [ { "database": "Reactome", "id": "R-HSA-9840373", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9840373" } ], "reference": [ { "type": "PubMed", "id": "32132706", "url": "https://glygen.org/publication/PubMed/32132706" } ] }, { "title": "Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway.", "journal": "Nature", "date": "2020", "authors": "Guo X, Aviles G, Liu Y, Tian R, Unger BA, Lin YT, Wiita AP, Xu K, Correia MA, Kampmann M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9840373", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9840373" } ], "reference": [ { "type": "PubMed", "id": "32132707", "url": "https://glygen.org/publication/PubMed/32132707" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05198", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05198" }, { "database": "O-GlcNAc Atlas", "id": "P05198", "url": "https://oglcnac.org/atlas/detail/P05198" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation.", "journal": "Brain pathology (Zurich, Switzerland)", "date": "2021-01", "authors": "Reimer Lasse, Betzer Cristine, Kofoed Rikke Hahn, Volbracht Christiane, Fog Karina, Kurhade Chaitanya, Nilsson Emma, \u00d6verby Anna K, Jensen Poul Henning", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "32716602", "url": "https://glygen.org/publication/PubMed/32716602" } ] }, { "title": "Cell fate determined by the activation balance between PKR and SPHK1.", "journal": "Cell death and differentiation", "date": "2021-01", "authors": "Qiao Han, Jiang Tianqing, Mu Peiqiang, Chen Xiaoxuan, Wen Xianhui, Hu Zhangsheng, Tang Shulin, Wen Jikai, Deng Yiqun", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "32801355", "url": "https://glygen.org/publication/PubMed/32801355" } ] }, { "title": "Is the emperor wearing shorts? The published structures of ABC transporters.", "journal": "FEBS letters", "date": "2020", "authors": "Jones PM, George AM", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "32981041", "url": "https://glygen.org/publication/PubMed/32981041" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05198", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05198" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis.", "journal": "Science (New York, N.Y.)", "date": "2021", "authors": "You K, Wang L, Chou CH, Liu K, Nakata T, Jaiswal A, Yao J, Lefkovith A, Omar A, Perrigoue JG, Towne JE, Regev A, Graham DB, Xavier RJ", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "reference": [ { "type": "PubMed", "id": "33384352", "url": "https://glygen.org/publication/PubMed/33384352" } ] }, { "title": "Generation of a mutant form of protein synthesis initiation factor eIF-2 lacking the site of phosphorylation by eIF-2 kinases.", "journal": "Molecular and cellular biology", "date": "1988", "authors": "Pathak VK, Schindler D, Hershey JW", "evidence": [ { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "reference": [ { "type": "PubMed", "id": "3352609", "url": "https://glygen.org/publication/PubMed/3352609" } ] }, { "title": "The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2.", "journal": "The Journal of biological chemistry", "date": "1988", "authors": "Rowlands AG, Panniers R, Henshaw EC", "evidence": [ { "database": "Reactome", "id": "R-HSA-72731", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72731" } ], "reference": [ { "type": "PubMed", "id": "3356695", "url": "https://glygen.org/publication/PubMed/3356695" } ] }, { "title": "The PKR/P38/RIPK1 Signaling Pathway as a Therapeutic Target in Alzheimer's Disease.", "journal": "International journal of molecular sciences", "date": "2021-03-19", "authors": "Hugon Jacques, Paquet Claire", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "33808629", "url": "https://glygen.org/publication/PubMed/33808629" } ] }, { "title": "PKR activity modulation by phosphomimetic mutations of serine residues located three aminoacids upstream of double-stranded RNA binding motifs.", "journal": "Scientific reports", "date": "2021-04-28", "authors": "Cesaro Teresa, Hayashi Yohei, Borghese Fabian, Vertommen Didier, Wavreil Fanny, Michiels Thomas", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "33911136", "url": "https://glygen.org/publication/PubMed/33911136" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05198", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05198" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "PERK-eIF2alpha-ERK1/2 axis drives mesenchymal-endothelial transition of cancer-associated fibroblasts in pancreatic cancer.", "journal": "Cancer letters", "date": "2021", "authors": "Cai W, Sun X, Jin F, Xiao D, Li H, Sun H, Wang Y, Lu Y, Liu J, Huang C, Wang X, Gao S, Wang H, Gao C, Zhao T, Hao J", "evidence": [ { "database": "RefSeq", "id": "NP_004085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004085" } ], "reference": [ { "type": "PubMed", "id": "34052329", "url": "https://glygen.org/publication/PubMed/34052329" } ] }, { "title": "Regulation of PKR activation and apoptosis during oxidative stress by TRBP phosphorylation.", "journal": "The international journal of biochemistry & cell biology", "date": "2021-08", "authors": "Ukhueduan Benedicth, Chukwurah Evelyn, Patel Rekha C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "34174402", "url": "https://glygen.org/publication/PubMed/34174402" } ] }, { "title": "Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification.", "journal": "Science (New York, N.Y.)", "date": "1986", "authors": "Shen DW, Fojo A, Chin JE, Roninson IB, Richert N, Pastan I, Gottesman MM", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "3457471", "url": "https://glygen.org/publication/PubMed/3457471" } ] }, { "title": "Higher-order phosphatase-substrate contacts terminate the integrated stress response.", "journal": "Nature structural & molecular biology", "date": "2021", "authors": "Yan Y, Harding HP, Ron D", "evidence": [ { "database": "RefSeq", "id": "NP_004085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004085" } ], "reference": [ { "type": "PubMed", "id": "34625748", "url": "https://glygen.org/publication/PubMed/34625748" } ] }, { "title": "Expression of a full-length cDNA for the human `MDR1` gene confers resistance to colchicine, doxorubicin, and vinblastine.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1987", "authors": "Ueda K, Cardarelli C, Gottesman MM, Pastan I", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "3472246", "url": "https://glygen.org/publication/PubMed/3472246" } ] }, { "title": "Truncation of the TPR domain of OGT alters substrate and glycosite selection.", "journal": "Analytical and bioanalytical chemistry", "date": "2021", "authors": "Ramirez DH, Yang B, D'Souza AK, Shen D, Woo CM", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05198", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05198" } ], "reference": [ { "type": "PubMed", "id": "34725712", "url": "https://glygen.org/publication/PubMed/34725712" } ] }, { "title": "Helicobacter pylori Targets in AGS Human Gastric Adenocarcinoma: In Situ Proteomic Profiling and Systematic Analysis.", "journal": "Anticancer research", "date": "2022", "authors": "Yang JS, Kang CY, Su CH, Chen CJ, Chiu YJ, Hsu YM", "evidence": [ { "database": "RefSeq", "id": "NP_004085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004085" } ], "reference": [ { "type": "PubMed", "id": "34969763", "url": "https://glygen.org/publication/PubMed/34969763" } ] }, { "title": "Nc886 promotes renal cancer cell drug-resistance by enhancing EMT through Rock2 phosphorylation-mediated \u03b2-catenin nuclear translocation.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2022-02", "authors": "Gao Weiyin, Zhang Shouhua, Guorong Li, Liu Queling, Zhu Anyi, Gui Fu, Zou Yan, Wu Yiguo, Luo Yang, Hong Zhengdong", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "34974812", "url": "https://glygen.org/publication/PubMed/34974812" } ] }, { "title": "Stepwise assembly of the eukaryotic translation initiation factor 2 complex.", "journal": "J. Biol. Chem.", "date": "2022", "authors": "Vanselow Sven, Neumann-Arnold Lea, Wojciech-Moock Franziska, Seufert Wolfgang", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "reference": [ { "type": "PubMed", "id": "35031321", "url": "https://glygen.org/publication/PubMed/35031321" } ] }, { "title": "Spatiotemporal Activation of Protein O-GlcNAcylation in Living Cells.", "journal": "Journal of the American Chemical Society", "date": "2022", "authors": "He J, Fan Z, Tian Y, Yang W, Zhou Y, Zhu Q, Zhang W, Qin W, Yi W", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05198", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05198" } ], "reference": [ { "type": "PubMed", "id": "35138101", "url": "https://glygen.org/publication/PubMed/35138101" } ] }, { "title": "The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer.", "journal": "International journal of molecular sciences", "date": "2022", "authors": "Cheng M, Yu H, Kong Q, Wang B, Shen L, Dong D, Sun L", "evidence": [ { "database": "Reactome", "id": "R-HSA-9840373", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9840373" } ], "reference": [ { "type": "PubMed", "id": "35163244", "url": "https://glygen.org/publication/PubMed/35163244" } ] }, { "title": "DELE1 tracks perturbed protein import and processing in human mitochondria.", "journal": "Nature communications", "date": "2022-04-06", "authors": "Fessler Evelyn, Krumwiede Luisa, Jae Lucas T", "evidence": [ { "database": "Reactome", "id": "R-HSA-9840373", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9840373" } ], "reference": [ { "type": "PubMed", "id": "35388015", "url": "https://glygen.org/publication/PubMed/35388015" } ] }, { "title": "Downregulation of nc886 contributes to prostate cancer cell invasion and TGF\u03b21-induced EMT.", "journal": "Genes & diseases", "date": "2022-07", "authors": "Yang Ronghui, Zuo Lingkun, Ma Hui, Zhou Ying, Zhou Ping, Wang Liyong, Wang Miao, Latif Mahrukh, Kong Lu", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "35685460", "url": "https://glygen.org/publication/PubMed/35685460" } ] }, { "title": "Mitochondrial double-stranded RNAs govern the stress response in chondrocytes to promote osteoarthritis development.", "journal": "Cell reports", "date": "2022-08-09", "authors": "Kim Sujin, Lee Keonyong, Choi Yong Seok, Ku Jayoung, Kim Hyeonkyeong, Kharbash Raisa, Yoon Jimin, Lee Yong Seuk, Kim Jin-Hong, Lee Yun Jong, Kim Yoosik", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "35947956", "url": "https://glygen.org/publication/PubMed/35947956" } ] }, { "title": "C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2\u03b1.", "journal": "Theranostics", "date": "2022", "authors": "Zheng Wenzhong, Wang Kexin, Wu Yachen, Yan Ge, Zhang Chi, Li Zhiqiang, Wang Lianrong, Chen Shi", "evidence": [ { "database": "RefSeq", "id": "NP_004085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004085" } ], "reference": [ { "type": "PubMed", "id": "36438488", "url": "https://glygen.org/publication/PubMed/36438488" } ] }, { "title": "Protein kinase R dependent phosphorylation of \u03b1-synuclein regulates its membrane binding and aggregation.", "journal": "PNAS nexus", "date": "2022-11", "authors": "Reimer Lasse, Gram Hjalte, Jensen Nanna M\u00f8ller, Betzer Cristine, Yang Li, Jin Lorrain, Shi Min, Boudeffa Driss, Fusco Giuliana, De Simone Alfonso, Kirik Deniz, Lashuel Hilal A, Zhang Jing, Jensen Poul Henning", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "36712380", "url": "https://glygen.org/publication/PubMed/36712380" } ] }, { "title": "Inhibition of RNA-binding proteins with small molecules.", "journal": "Nature reviews. Chemistry", "date": "2020-09", "authors": "Wu Peng", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "37127961", "url": "https://glygen.org/publication/PubMed/37127961" } ] }, { "title": "Extracellular arginine availability modulates eIF2\u03b1 O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis.", "journal": "Journal of biomedical science", "date": "2023-05-22", "authors": "Hung Yu-Wen, Ouyang Ching, Ping Xiaoli, Qi Yue, Wang Yi-Chang, Kung Hsing-Jien, Ann David K", "evidence": [ { "database": "O-GlcNAc Database", "id": "P05198", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05198" } ], "reference": [ { "type": "PubMed", "id": "37217939", "url": "https://glygen.org/publication/PubMed/37217939" } ] }, { "title": "A mitochondrial iron-responsive pathway regulated by DELE1.", "journal": "Molecular cell", "date": "2023-06-15", "authors": "Sekine Yusuke, Houston Ryan, Eckl Eva-Maria, Fessler Evelyn, Narendra Derek P, Jae Lucas T, Sekine Shiori", "evidence": [ { "database": "Reactome", "id": "R-HSA-9840373", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9840373" } ], "reference": [ { "type": "PubMed", "id": "37327776", "url": "https://glygen.org/publication/PubMed/37327776" } ] }, { "title": "Activation of BZW1 by CEBPB in macrophages promotes eIF2\u03b1 phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice.", "journal": "Cellular & molecular biology letters", "date": "2023-10-12", "authors": "Qi Huimeng, Zheng Zhaoguo, Liu Qiang", "evidence": [ { "database": "RefSeq", "id": "NP_004085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004085" } ], "reference": [ { "type": "PubMed", "id": "37828427", "url": "https://glygen.org/publication/PubMed/37828427" } ] }, { "title": "Binding and release of radiolabeled eukaryotic initiation factors 2 and 3 during 80 S initiation complex formation.", "journal": "The Journal of biological chemistry", "date": "1979", "authors": "Peterson DT, Merrick WC, Safer B", "evidence": [ { "database": "Reactome", "id": "R-HSA-72695", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72695" } ], "reference": [ { "type": "PubMed", "id": "429297", "url": "https://glygen.org/publication/PubMed/429297" } ] }, { "title": "Initiation of mammalian protein synthesis. I. Purification and characterization of seven initiation factors.", "journal": "Journal of molecular biology", "date": "1977", "authors": "Schreier MH, Erni B, Staehelin T", "evidence": [ { "database": "Reactome", "id": "R-HSA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72706" } ], "reference": [ { "type": "PubMed", "id": "592398", "url": "https://glygen.org/publication/PubMed/592398" } ] }, { "title": "Initiation of mammalian protein synthesis. II. The assembly of the initiation complex with purified initiation factors.", "journal": "Journal of molecular biology", "date": "1977", "authors": "Trachsel H, Erni B, Schreier MH, Staehelin T", "evidence": [ { "database": "Reactome", "id": "R-HSA-72649", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72649" } ], "reference": [ { "type": "PubMed", "id": "592399", "url": "https://glygen.org/publication/PubMed/592399" } ] }, { "title": "The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes.", "journal": "The Journal of biological chemistry", "date": "1978", "authors": "Benne R, Hershey JW", "evidence": [ { "database": "Reactome", "id": "R-HSA-72649", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72649" } ], "reference": [ { "type": "PubMed", "id": "641056", "url": "https://glygen.org/publication/PubMed/641056" } ] }, { "title": "New initiation factor activity required for globin mRNA translation.", "journal": "The Journal of biological chemistry", "date": "1983", "authors": "Grifo JA, Tahara SM, Morgan MA, Shatkin AJ, Merrick WC", "evidence": [ { "database": "Reactome", "id": "R-HSA-72649", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72649" } ], "reference": [ { "type": "PubMed", "id": "6853548", "url": "https://glygen.org/publication/PubMed/6853548" } ] }, { "title": "Evaluation of the `scanning model` for initiation of protein synthesis in eucaryotes.", "journal": "Cell", "date": "1980", "authors": "Kozak M", "evidence": [ { "database": "Reactome", "id": "R-HSA-72702", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72702" } ], "reference": [ { "type": "PubMed", "id": "7000367", "url": "https://glygen.org/publication/PubMed/7000367" } ] }, { "title": "HIV-1 Tat directly interacts with the interferon-induced, double-stranded RNA-dependent kinase, PKR.", "journal": "Virology", "date": "1995-11-10", "authors": "McMillan N A, Chun R F, Siderovski D P, Galabru J, Toone W M, Samuel C E, Mak T W, Hovanessian A G, Jeang K T, Williams B R", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "7491766", "url": "https://glygen.org/publication/PubMed/7491766" } ] }, { "title": "TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1994-05-24", "authors": "Park H, Davies M V, Langland J O, Chang H W, Nam Y S, Tartaglia J, Paoletti E, Jacobs B L, Kaufman R J, Venkatesan S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "7515177", "url": "https://glygen.org/publication/PubMed/7515177" } ] }, { "title": "Intracellular turnover of cystic fibrosis transmembrane conductance regulator. Inefficient processing and rapid degradation of wild-type and mutant proteins.", "journal": "The Journal of biological chemistry", "date": "1994", "authors": "Ward CL, Kopito RR", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "7523390", "url": "https://glygen.org/publication/PubMed/7523390" } ] }, { "title": "Conformational maturation of CFTR but not its mutant counterpart (delta F508) occurs in the endoplasmic reticulum and requires ATP.", "journal": "The EMBO journal", "date": "1994", "authors": "Lukacs GL, Mohamed A, Kartner N, Chang XB, Riordan JR, Grinstein S", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "7529176", "url": "https://glygen.org/publication/PubMed/7529176" } ] }, { "title": "The interferon-inducible double-stranded RNA-activated protein kinase self-associates in vitro and in vivo.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1995-08-29", "authors": "Patel R C, Stanton P, McMillan N M, Williams B R, Sen G C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "7545299", "url": "https://glygen.org/publication/PubMed/7545299" } ] }, { "title": "Degradation of CFTR by the ubiquitin-proteasome pathway.", "journal": "Cell", "date": "1995", "authors": "Ward CL, Omura S, Kopito RR", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "7553863", "url": "https://glygen.org/publication/PubMed/7553863" } ] }, { "title": "Multiple proteolytic systems, including the proteasome, contribute to CFTR processing.", "journal": "Cell", "date": "1995", "authors": "Jensen TJ, Loo MA, Pind S, Williams DB, Goldberg AL, Riordan JR", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "7553864", "url": "https://glygen.org/publication/PubMed/7553864" } ] }, { "title": "Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase.", "journal": "Molecular and cellular biology", "date": "1995-10", "authors": "Patterson J B, Samuel C E", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "7565688", "url": "https://glygen.org/publication/PubMed/7565688" } ] }, { "title": "Mechanism of interferon action: evidence for intermolecular autophosphorylation and autoactivation of the interferon-induced, RNA-dependent protein kinase PKR.", "journal": "Journal of virology", "date": "1993-12", "authors": "Thomis D C, Samuel C E", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "7693978", "url": "https://glygen.org/publication/PubMed/7693978" } ] }, { "title": "Nuclear localization of the interferon-inducible protein kinase PKR in human cells and transfected mouse cells.", "journal": "Experimental cell research", "date": "1995-05", "authors": "Jeffrey I W, Kadereit S, Meurs E F, Metzger T, Bachmann M, Schwemmle M, Hovanessian A G, Clemens M J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "7737357", "url": "https://glygen.org/publication/PubMed/7737357" } ] }, { "title": "P-glycoprotein mediates profound resistance to bisantrene.", "journal": "Oncology research", "date": "1994", "authors": "Zhang XP, Ritke MK, Yalowich JC, Slovak ML, Ho JP, Collins KI, Annable T, Arceci RJ, Durr FE, Greenberger LM", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "7865904", "url": "https://glygen.org/publication/PubMed/7865904" } ] }, { "title": "Organization of the double-stranded RNA-activated protein kinase DAI and virus-associated VA RNAI in adenovirus-2-infected HeLa cells.", "journal": "Journal of cell science", "date": "1993-09", "authors": "Jim\u00e9nez-Garc\u00eda L F, Green S R, Mathews M B, Spector D L", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "7903669", "url": "https://glygen.org/publication/PubMed/7903669" } ] }, { "title": "Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1993", "authors": "Dever TE, Chen JJ, Barber GN, Cigan AM, Feng L, Donahue TF, London IM, Katze MG, Hinnebusch AG", "evidence": [ { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "reference": [ { "type": "PubMed", "id": "8099443", "url": "https://glygen.org/publication/PubMed/8099443" } ] }, { "title": "Regulation of the C/EBP-related gene gadd153 by glucose deprivation.", "journal": "Molecular and cellular biology", "date": "1993", "authors": "Carlson SG, Fawcett TW, Bartlett JD, Bernier M, Holbrook NJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9633012", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9633012" } ], "reference": [ { "type": "PubMed", "id": "8336711", "url": "https://glygen.org/publication/PubMed/8336711" } ] }, { "title": "The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity.", "journal": "The Journal of biological chemistry", "date": "1996-01-19", "authors": "Polyak S J, Tang N, Wambach M, Barber G N, Katze M G", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "8576172", "url": "https://glygen.org/publication/PubMed/8576172" } ] }, { "title": "Double-stranded (ds) RNA binding and not dimerization correlates with the activation of the dsRNA-dependent protein kinase (PKR).", "journal": "The Journal of biological chemistry", "date": "1996-01-19", "authors": "Wu S, Kaufman R J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "8576179", "url": "https://glygen.org/publication/PubMed/8576179" } ] }, { "title": "Characterization of the heparin-mediated activation of PKR, the interferon-inducible RNA-dependent protein kinase.", "journal": "Virology", "date": "1996-07-01", "authors": "George C X, Thomis D C, McCormack S J, Svahn C M, Samuel C E", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "8661426", "url": "https://glygen.org/publication/PubMed/8661426" } ] }, { "title": "Specific mutations near the amino terminus of double-stranded RNA-dependent protein kinase (PKR) differentially affect its double-stranded RNA binding and dimerization properties.", "journal": "The Journal of biological chemistry", "date": "1996-10-11", "authors": "Patel R C, Stanton P, Sen G C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "8810342", "url": "https://glygen.org/publication/PubMed/8810342" } ] }, { "title": "The 58-kDa cellular inhibitor of the double stranded RNA-dependent protein kinase requires the tetratricopeptide repeat 6 and DnaJ motifs to stimulate protein synthesis in vivo.", "journal": "The Journal of biological chemistry", "date": "1996-11-08", "authors": "Tang N M, Ho C Y, Katze M G", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "8910500", "url": "https://glygen.org/publication/PubMed/8910500" } ] }, { "title": "Functional dissection of eukaryotic initiation factor 4F: the 4A subunit and the central domain of the 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes.", "journal": "Molecular and cellular biology", "date": "1996", "authors": "Pestova TV, Shatsky IN, Hellen CU", "evidence": [ { "database": "Reactome", "id": "R-HSA-72702", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72702" } ], "reference": [ { "type": "PubMed", "id": "8943342", "url": "https://glygen.org/publication/PubMed/8943342" } ] }, { "title": "Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR.", "journal": "The EMBO journal", "date": "1997-02-03", "authors": "Benkirane M, Neuveut C, Chun R F, Smith S M, Samuel C E, Gatignol A, Jeang K T", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "9034343", "url": "https://glygen.org/publication/PubMed/9034343" } ] }, { "title": "Requirement of the DEAD-Box protein ded1p for messenger RNA translation.", "journal": "Science (New York, N.Y.)", "date": "1997", "authors": "Chuang RY, Weaver PL, Liu Z, Chang TH", "evidence": [ { "database": "Reactome", "id": "R-HSA-72702", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72702" } ], "reference": [ { "type": "PubMed", "id": "9045610", "url": "https://glygen.org/publication/PubMed/9045610" } ] }, { "title": "The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR.", "journal": "The Journal of biological chemistry", "date": "1997-03-28", "authors": "Brand S R, Kobayashi R, Mathews M B", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "9079663", "url": "https://glygen.org/publication/PubMed/9079663" } ] }, { "title": "Mammalian GADD34, an apoptosis- and DNA damage-inducible gene.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Hollander MC, Zhan Q, Bae I, Fornace AJ Jr", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648895", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648895" } ], "reference": [ { "type": "PubMed", "id": "9153226", "url": "https://glygen.org/publication/PubMed/9153226" } ] }, { "title": "Amino acid limitation induces expression of CHOP, a CCAAT/enhancer binding protein-related gene, at both transcriptional and post-transcriptional levels.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Bruhat A, Jousse C, Wang XZ, Ron D, Ferrara M, Fafournoux P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9633012", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9633012" } ], "reference": [ { "type": "PubMed", "id": "9211906", "url": "https://glygen.org/publication/PubMed/9211906" } ] }, { "title": "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45.", "journal": "The Journal of biological chemistry", "date": "1998-01-23", "authors": "Ting N S, Kao P N, Chan D W, Lintott L G, Lees-Miller S P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "9442054", "url": "https://glygen.org/publication/PubMed/9442054" } ] }, { "title": "Ultrastructural localization of interferon-inducible double-stranded RNA-activated enzymes in human cells.", "journal": "Experimental cell research", "date": "1998-03-15", "authors": "Besse S, Rebouillat D, Marie I, Puvion-Dutilleul F, Hovanessian A G", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "9521856", "url": "https://glygen.org/publication/PubMed/9521856" } ] }, { "title": "Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2.", "journal": "Molecular and cellular biology", "date": "1998", "authors": "Romano PR, Garcia-Barrio MT, Zhang X, Wang Q, Taylor DR, Zhang F, Herring C, Mathews MB, Qin J, Hinnebusch AG", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "9528799", "url": "https://glygen.org/publication/PubMed/9528799" } ] }, { "title": "Stoichiometry of coupling of rhodamine 123 transport to ATP hydrolysis by P-glycoprotein.", "journal": "European journal of biochemistry", "date": "1998", "authors": "Shapiro AB, Ling V", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "9652413", "url": "https://glygen.org/publication/PubMed/9652413" } ] }, { "title": "PACT, a protein activator of the interferon-induced protein kinase, PKR.", "journal": "The EMBO journal", "date": "1998", "authors": "Patel RC, Sen GC", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "9687506", "url": "https://glygen.org/publication/PubMed/9687506" } ] }, { "title": "Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons.", "journal": "Nature", "date": "1998", "authors": "Pestova TV, Borukhov SI, Hellen CU", "evidence": [ { "database": "Reactome", "id": "R-HSA-72649", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72649" } ], "reference": [ { "type": "PubMed", "id": "9732867", "url": "https://glygen.org/publication/PubMed/9732867" } ] }, { "title": "Tumor suppressor p53 as a component of the tumor necrosis factor-induced, protein kinase PKR-mediated apoptotic pathway in human promonocytic U937 cells.", "journal": "The Journal of biological chemistry", "date": "1998-09-25", "authors": "Yeung M C, Lau A S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "9737981", "url": "https://glygen.org/publication/PubMed/9737981" } ] }, { "title": "Retroviral transfer of the human MDR1 gene confers resistance to bisantrene-specific hematotoxicity.", "journal": "Clinical cancer research : an official journal of the American Association for Cancer Research", "date": "1996", "authors": "Aksentijevich I, Cardarelli CO, Pastan I, Gottesman MM", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "9816258", "url": "https://glygen.org/publication/PubMed/9816258" } ] }, { "title": "Requirement of PKR dimerization mediated by specific hydrophobic residues for its activation by double-stranded RNA and its antigrowth effects in yeast.", "journal": "Molecular and cellular biology", "date": "1998-12", "authors": "Patel R C, Sen G C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "9819388", "url": "https://glygen.org/publication/PubMed/9819388" } ] }, { "title": "Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control.", "journal": "Molecular and cellular biology", "date": "1998", "authors": "Shi Y, Vattem KM, Sood R, An J, Liang J, Stramm L, Wek RC", "evidence": [ { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "reference": [ { "type": "PubMed", "id": "9819435", "url": "https://glygen.org/publication/PubMed/9819435" } ] }, { "title": "Reconstituted human cardiac KATP channels: functional identity with the native channels from the sarcolemma of human ventricular cells.", "journal": "Circulation research", "date": "1998", "authors": "Babenko AP, Gonzalez G, Aguilar-Bryan L, Bryan J", "evidence": [ { "database": "Reactome", "id": "R-HSA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556" } ], "reference": [ { "type": "PubMed", "id": "9831708", "url": "https://glygen.org/publication/PubMed/9831708" } ] }, { "title": "A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation.", "journal": "The EMBO journal", "date": "1998", "authors": "Imataka H, Gradi A, Sonenberg N", "evidence": [ { "database": "Reactome", "id": "R-HSA-72649", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72649" } ], "reference": [ { "type": "PubMed", "id": "9857202", "url": "https://glygen.org/publication/PubMed/9857202" } ] }, { "title": "The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Melville MW, Tan SL, Wambach M, Song J, Morimoto RI, Katze MG", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482" } ], "reference": [ { "type": "PubMed", "id": "9920933", "url": "https://glygen.org/publication/PubMed/9920933" } ] }, { "title": "Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase.", "journal": "Nature", "date": "1999", "authors": "Harding HP, Zhang Y, Ron D", "evidence": [ { "database": "iPTMnet", "id": "P05198", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05198" } ], "reference": [ { "type": "PubMed", "id": "9930704", "url": "https://glygen.org/publication/PubMed/9930704" } ] } ], "pathway": [ { "id": "hsa:1965", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:1965", "resource": "KEGG Pathway" }, { "id": "R-HSA-156827", "name": "L13a-mediated translational silencing of Ceruloplasmin expression", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-HSA-381042", "name": "PERK regulates gene expression", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381042", "resource": "Reactome", "description": "PERK regulates gene expression" }, { "id": "R-HSA-382556", "name": "ABC-family proteins mediated transport", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-382556", "resource": "Reactome", "description": "ABC-family proteins mediated transport" }, { "id": "R-HSA-72649", "name": "Translation initiation complex formation", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72649", "resource": "Reactome", "description": "Translation initiation complex formation" }, { "id": "R-HSA-72695", "name": "Formation of the ternary complex, and subsequently, the 43S complex", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72695", "resource": "Reactome", "description": "Formation of the ternary complex, and subsequently, the 43S complex" }, { "id": "R-HSA-72702", "name": "Ribosomal scanning and start codon recognition", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72702", "resource": "Reactome", "description": "Ribosomal scanning and start codon recognition" }, { "id": "R-HSA-72706", "name": "GTP hydrolysis and joining of the 60S ribosomal subunit", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-HSA-72731", "name": "Recycling of eIF2:GDP", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72731", "resource": "Reactome", "description": "Recycling of eIF2:GDP" }, { "id": "R-HSA-9633012", "name": "Response of EIF2AK4 (GCN2) to amino acid deficiency", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9633012", "resource": "Reactome", "description": "Response of EIF2AK4 (GCN2) to amino acid deficiency" }, { "id": "R-HSA-9648895", "name": "Response of EIF2AK1 (HRI) to heme deficiency", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648895", "resource": "Reactome", "description": "Response of EIF2AK1 (HRI) to heme deficiency" }, { "id": "R-HSA-9833482", "name": "PKR-mediated signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833482", "resource": "Reactome", "description": "PKR-mediated signaling" }, { "id": "R-HSA-9840373", "name": "Cellular response to mitochondrial stress", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9840373", "resource": "Reactome", "description": "Cellular response to mitochondrial stress" } ], "orthologs": [ { "uniprot_canonical_ac": "P20459-1", "protein_name": "Eukaryotic translation initiation factor 2 subunit alpha", "gene_name": "SUI2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSTSHCRFYENKYPEIDDIVMVNVQQIAEMGAYVKLLEYDNIEGMILLSELSRRRIRSIQKLIRVGKNDVAVVLRVDKEKGYIDLSKRRVSSEDIIKCEEKYQKSKTVHSILRYCAEKFQIPLEELYKTIAWPLSRKFGHAYEAFKLSIIDETVWEGIEPPSKDVLDELKNYISKRLTPQAVKIRADVEVSCFSYEGIDAIKDALKSAEDMSTEQMQVKVKLVAAPLYVLTTQALDKQKGIEQLESAIEKITEVITKYGGVCNITMPPKAVTATEDAELQALLESKELDNRSDSEDDEDESDDE", "length": 304 }, "evidence": [ { "id": "P05198", "url": "https://omabrowser.org/oma/group/P05198/", "database": "OMA" } ], "common_name": "Yeast" }, { "uniprot_canonical_ac": "P41374-1", "protein_name": "Eukaryotic translation initiation factor 2 subunit 1", "gene_name": "eIF2alpha", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MALTSRFYNERYPEIEDVVMVNVLSIAEMGAYVHLLEYNNIEGMILLSELSRRRIRSINKLIRVGKTEPVVVIRVDKEKGYIDLSKRRVSPEDVEKCTERFAKAKAINSLLRHVADILGFEGNEKLEDLYQKTAWHFEKKYNNKTVAYDIFKQSVTDPTVFDECNLEPETKEVLLSNIKRKLVSPTVKIRADIECSCYGYEGIDAVKASLTKGLELSTEELPIRINLIAPPLYVMTTSTTKKTDGLKALEVAIEHIRAKTSEYDGEFKVIMAPKLVTAIDEADLARRLERAEAENAQVAGDDDEEDGADQEGMQFDPEKEFNHKGSGAGRANEEDEEEEED", "length": 341 }, "evidence": [ { "id": "P05198", "url": "https://omabrowser.org/oma/group/P05198/", "database": "OMA" } ], "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P68101-1", "protein_name": "Eukaryotic translation initiation factor 2 subunit 1", "gene_name": "Eif2s1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTETMPIKINLIAPPRYVMTTTTLERTEGLSVLNQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQLERLERENAEVDGDDDAEEMEAKAED", "length": 315 }, "evidence": [ { "id": "45918155", "url": "http://www.informatics.jax.org/homology/45918155", "database": "MGI" }, { "id": "P05198", "url": "https://omabrowser.org/oma/group/P05198/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6ZWX6-1", "protein_name": "Eukaryotic translation initiation factor 2 subunit 1", "gene_name": "Eif2s1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTETMPIKINLIAPPRYVMTTTTLERTEGLSVLNQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQLERLERENAEVDGDDDAEEMEAKAED", "length": 315 }, "evidence": [ { "id": "45918155", "url": "http://www.informatics.jax.org/homology/45918155", "database": "MGI" }, { "id": "P05198", "url": "https://omabrowser.org/oma/group/P05198/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" }, { "name": "translation initiation factor activity", "id": "GO:0003743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003743", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" }, { "name": "ribosome binding", "id": "GO:0043022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043022", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 11, "go_terms": [ { "name": "cytoplasmic stress granule", "id": "GO:0010494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010494", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" }, { "name": "translation initiation ternary complex", "id": "GO:0044207", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044207", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" }, { "name": "glial limiting end-foot", "id": "GO:0097451", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097451", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" }, { "name": "polysome", "id": "GO:0005844", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005844", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" }, { "name": "eukaryotic 48S preinitiation complex", "id": "GO:0033290", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033290", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" }, { "name": "eukaryotic translation initiation factor 2 complex", "id": "GO:0005850", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005850", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 14, "go_terms": [ { "name": "cellular response to heat", "id": "GO:0034605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034605", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" }, { "name": "translational initiation", "id": "GO:0006413", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006413", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" }, { "name": "cellular response to oxidative stress", "id": "GO:0034599", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034599", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" }, { "name": "PERK-mediated unfolded protein response", "id": "GO:0036499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036499", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" }, { "name": "response to endoplasmic reticulum stress", "id": "GO:0034976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034976", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" }, { "name": "cellular response to amino acid starvation", "id": "GO:0034198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034198", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" }, { "name": "cellular response to UV", "id": "GO:0034644", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034644", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" }, { "name": "stress granule assembly", "id": "GO:0034063", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034063", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" }, { "name": "negative regulation of translational initiation in response to stress", "id": "GO:0032057", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032057", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" }, { "name": "response to manganese-induced endoplasmic reticulum stress", "id": "GO:1990737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990737", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" }, { "name": "response to kainic acid", "id": "GO:1904373", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904373", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" }, { "name": "positive regulation of type B pancreatic cell apoptotic process", "id": "GO:2000676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000676", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" }, { "name": "regulation of translational initiation in response to stress", "id": "GO:0043558", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043558", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" }, { "name": "regulation of translation in response to endoplasmic reticulum stress", "id": "GO:0036490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036490", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 217, "end_pos": 219, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "(Microbial infection) Phosphorylation by vaccinia virus protein E3 and rotavirus A stabilizes the eIF-2/GDP/eIF2B complex and prevents GDP/GTP exchange reaction, thus impairing the recycling of eIF2 between successive rounds of initiation and leading to global inhibition of translation.", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" }, { "database": "PubMed", "id": "15207627", "url": "https://glygen.org/publication/PubMed/15207627" }, { "database": "PubMed", "id": "18032499", "url": "https://glygen.org/publication/PubMed/18032499" } ] }, { "annotation": "Phosphorylation at Ser-49 and Ser-52 stabilizes the eIF-2/GDP/eIF2B complex and prevents GDP/GTP exchange reaction, thus impairing the recycling of eIF2 between successive rounds of initiation and leading to global inhibition of translation, while concomitantly initiating the preferential translation of integrated stress response (ISR)-specific mRNAs (PubMed:15207627, PubMed:18032499, PubMed:19131336, PubMed:31048492). Substrate for at least 4 kinases: EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2 (By similarity). Phosphorylated; phosphorylation on Ser-52 by the EIF2AK4/GCN2 protein kinase occurs in response to amino acid starvation and UV irradiation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P05198", "url": "https://www.uniprot.org/uniprot/P05198" }, { "database": "PubMed", "id": "15207627", "url": "https://glygen.org/publication/PubMed/15207627" }, { "database": "PubMed", "id": "18032499", "url": "https://glygen.org/publication/PubMed/18032499" }, { "database": "PubMed", "id": "19131336", "url": "https://glygen.org/publication/PubMed/19131336" }, { "database": "PubMed", "id": "31048492", "url": "https://glygen.org/publication/PubMed/31048492" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [ 217 ], "o_linked_sites": [ 219, 239, 240, 241 ], "snv_sites": [ 219, 224, 239, 240, 241 ], "glycation_sites": [], "phosphorylation_sites": [ 49, 52, 58, 158, 279, 281 ], "sequon_annotation_sites": [ { "start_pos": 217, "end_pos": 219 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 4 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 4 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 15 }, { "field": "total_sites", "count": 6 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 301 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }