{
"uniprot_canonical_ac": "P05181-1",
"uniprot_ac": "P05181",
"uniprot_id": "CP2E1_HUMAN",
"mass": {
"chemical_mass": 56849.0,
"monoisotopic_mass": 56849.0
},
"refseq": {
"ac": "NP_000764",
"name": "cytochrome P450 2E1",
"summary": "This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008].",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000764"
},
"gene_names": [
{
"name": "CYP2E1",
"resource": "UniProtKB",
"type": "recommended",
"url": "https://www.uniprot.org/uniprot/P05181",
"id": "P05181"
},
{
"name": "CPE1; CYP2E; P450-J; P450C2E",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000764",
"id": "NP_000764"
},
{
"name": "CYP2E1",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000764",
"id": "NP_000764"
},
{
"name": "CYP2E",
"resource": "UniProtKB",
"type": "synonym",
"url": "https://www.uniprot.org/uniprot/P05181",
"id": "P05181"
}
],
"protein_names": [
{
"name": "Cytochrome P450 2E1",
"resource": "UniProtKB",
"type": "recommended",
"url": "",
"id": "P05181"
},
{
"name": "1.14.13.n7",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P05181"
},
{
"name": "1.14.14.1",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P05181"
},
{
"name": "4-nitrophenol 2-hydroxylase",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P05181"
},
{
"name": "CYPIIE1",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P05181"
},
{
"name": "Cytochrome P450-J",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P05181"
},
{
"name": "cytochrome P450 2E1",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000764",
"id": "NP_000764"
},
{
"name": "microsomal monooxygenase; xenobiotic monooxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1; CYPIIE1; cytochrome P450-J; 4-nitrophenol 2-hydroxylase; cytochrome P450, family 2, subfamily E, polypeptide 1",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000764",
"id": "NP_000764"
}
],
"function": [
{
"annotation": "A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:10553002, PubMed:18577768). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10553002, PubMed:18577768). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids (PubMed:10553002, PubMed:18577768). May be involved in the oxidative metabolism of xenobiotics (Probable).",
"evidence": [
{
"database": "UniProtKB",
"id": "P05181",
"url": "https://www.uniprot.org/uniprot/P05181#function"
},
{
"database": "PubMed",
"id": "9348445",
"url": "https://glygen.org/publication/PubMed/9348445"
},
{
"database": "PubMed",
"id": "18577768",
"url": "https://glygen.org/publication/PubMed/18577768"
},
{
"database": "PubMed",
"id": "10553002",
"url": "https://glygen.org/publication/PubMed/10553002"
}
]
},
{
"annotation": "A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.",
"evidence": [
{
"database": "UniProtKB",
"id": "F5H694",
"url": "https://www.uniprot.org/uniprot/F5H694#function"
},
{
"database": "UniProtKB",
"id": "RU368050",
"url": "https://www.uniprot.org/uniprot/RU368050#function"
}
]
},
{
"annotation": "ADH1B, ADH1B/C and CYP2E1 Gene Polymorphism and the Risk of Fetal Alcohol Spectrum Disorder. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000764",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000764"
},
{
"database": "PubMed",
"id": "37510297",
"url": "https://glygen.org/publication/PubMed/37510297"
}
]
},
{
"annotation": "CYP2E1 C-1054T and 96-bp I/D genetic variations and risk of gestational diabetes mellitus in chinese women: a case-control study. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000764",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000764"
},
{
"database": "PubMed",
"id": "37264354",
"url": "https://glygen.org/publication/PubMed/37264354"
}
]
},
{
"annotation": "CYP2E1 triggered GRP78/ATF6/CHOP signaling axis inhibit apoptosis and promotes progression of hepatocellular carcinoma.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000764",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000764"
},
{
"database": "PubMed",
"id": "37499993",
"url": "https://glygen.org/publication/PubMed/37499993"
}
]
},
{
"annotation": "Influence of alcohol consumption and alcohol metabolism variants on breast cancer risk among Black women: results from the AMBER consortium. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000764",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000764"
},
{
"database": "PubMed",
"id": "37308906",
"url": "https://glygen.org/publication/PubMed/37308906"
}
]
},
{
"annotation": "This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008].",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000764",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000764"
}
]
},
{
"annotation": "USP14 governs CYP2E1 to promote nonalcoholic fatty liver disease through deubiquitination and stabilization of HSP90AA1. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000764",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000764"
},
{
"database": "PubMed",
"id": "37633951",
"url": "https://glygen.org/publication/PubMed/37633951"
}
]
}
],
"disease": [],
"snv": [],
"mutagenesis": [],
"expression_tissue": [
{
"tissue": {
"name": "Adult mammalian kidney",
"namespace": "UBERON",
"id": "0000082",
"url": "http://purl.obolibrary.org/obo/UBERON_0000082"
},
"score": "72.04",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000130649",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000130649"
}
]
},
{
"tissue": {
"name": "Oral cavity",
"namespace": "UBERON",
"id": "0000167",
"url": "http://purl.obolibrary.org/obo/UBERON_0000167"
},
"score": "78.5",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000130649",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000130649"
}
]
},
{
"tissue": {
"name": "Stomach",
"namespace": "UBERON",
"id": "0000945",
"url": "http://purl.obolibrary.org/obo/UBERON_0000945"
},
"score": "70.97",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000130649",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000130649"
}
]
},
{
"tissue": {
"name": "Uterus",
"namespace": "UBERON",
"id": "0000995",
"url": "http://purl.obolibrary.org/obo/UBERON_0000995"
},
"score": "49.96",
"present": "LOW",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000130649",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000130649"
}
]
},
{
"tissue": {
"name": "Esophagus",
"namespace": "UBERON",
"id": "0001043",
"url": "http://purl.obolibrary.org/obo/UBERON_0001043"
},
"score": "77.73",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000130649",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000130649"
}
]
},
{
"tissue": {
"name": "Rectum",
"namespace": "UBERON",
"id": "0001052",
"url": "http://purl.obolibrary.org/obo/UBERON_0001052"
},
"score": "67.73",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000130649",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000130649"
}
]
},
{
"tissue": {
"name": "Colon",
"namespace": "UBERON",
"id": "0001155",
"url": "http://purl.obolibrary.org/obo/UBERON_0001155"
},
"score": "57.82",
"present": "LOW",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000130649",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000130649"
}
]
},
{
"tissue": {
"name": "Urinary bladder",
"namespace": "UBERON",
"id": "0001255",
"url": "http://purl.obolibrary.org/obo/UBERON_0001255"
},
"score": "64.62",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000130649",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000130649"
}
]
},
{
"tissue": {
"name": "Thyroid gland",
"namespace": "UBERON",
"id": "0002046",
"url": "http://purl.obolibrary.org/obo/UBERON_0002046"
},
"score": "72.95",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000130649",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000130649"
}
]
},
{
"tissue": {
"name": "Lung",
"namespace": "UBERON",
"id": "0002048",
"url": "http://purl.obolibrary.org/obo/UBERON_0002048"
},
"score": "47.6",
"present": "LOW",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000130649",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000130649"
}
]
},
{
"tissue": {
"name": "Liver",
"namespace": "UBERON",
"id": "0002107",
"url": "http://purl.obolibrary.org/obo/UBERON_0002107"
},
"score": "99.86",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000130649",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000130649"
}
]
},
{
"tissue": {
"name": "Prostate gland",
"namespace": "UBERON",
"id": "0002367",
"url": "http://purl.obolibrary.org/obo/UBERON_0002367"
},
"score": "81.08",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000130649",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000130649"
}
]
},
{
"tissue": {
"name": "Thoracic mammary gland",
"namespace": "UBERON",
"id": "0005200",
"url": "http://purl.obolibrary.org/obo/UBERON_0005200"
},
"score": "72.11",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000130649",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000130649"
}
]
}
],
"expression_disease": [
{
"significant": "Yes",
"trend": "down",
"name": "Prostate cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10283",
"evidence": [
{
"database": "BioXpress",
"id": "P05181",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05181"
}
],
"disease": [
{
"disease_id": "DOID:10283",
"recommended_name": {
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer",
"description": "A male reproductive organ cancer that is located_in the prostate."
},
"synonyms": [
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "NGP - new growth of prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "malignant tumor of the prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "tumor of the prostate",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, type 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "HPC9",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "EHBP1 familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "familial prostate cancer caused by mutation in EHBP1",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, type 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "HPC12",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, type 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "HPC5",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, type 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, susceptibility to, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "HPC3",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, type 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, susceptibility to, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "HPC4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, on chromosome 7",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "MSMB familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "familial prostate cancer caused by mutation in MSMB",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, type 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "HPC13",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, type 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "HPC8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "predisposing for prostate cancer",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, type 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "HPC6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "HPC10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate carcinoma",
"description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate carcinoma",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, somatic",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, hereditary",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "HPC7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer aggressiveness",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "RNASEL familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "familial prostate cancer caused by mutation in RNASEL",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, type 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "HPC1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "Prca1",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "HPC11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "HPC14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "HPC15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "HPCX1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer susceptibility, X-linked",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "HPCX2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MIM:611868",
"resource": "MIM",
"url": "https://www.omim.org/entry/611868",
"name": "Prostate cancer, hereditary, 12",
"description": "Prostate cancer, hereditary, 12"
},
{
"id": "MIM:611928",
"resource": "MIM",
"url": "https://www.omim.org/entry/611928",
"name": "Prostate cancer, hereditary, 13",
"description": "Prostate cancer, hereditary, 13"
},
{
"id": "MIM:176807",
"resource": "MIM",
"url": "https://www.omim.org/entry/176807",
"name": "Prostate cancer",
"description": "Prostate cancer"
},
{
"id": "MIM:601518",
"resource": "MIM",
"url": "https://www.omim.org/entry/601518",
"name": "Prostate cancer, hereditary, 1",
"description": "Prostate cancer, hereditary, 1"
},
{
"id": "MIM:611955",
"resource": "MIM",
"url": "https://www.omim.org/entry/611955",
"name": "Prostate cancer, hereditary, 11",
"description": "Prostate cancer, hereditary, 11"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Stomach cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10534",
"evidence": [
{
"database": "BioXpress",
"id": "P05181",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05181"
}
],
"disease": [
{
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"recommended_name": {
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "stomach cancer",
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},
"synonyms": [
{
"id": "DOID:10534",
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"name": "gastric cancer",
"description": ""
},
{
"id": "DOID:10534",
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"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric neoplasm",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": "A primary or metastatic malignant neoplasm involving the stomach."
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca lesser curvature - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "cancer of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer risk after h. pylori infection",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumor",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumour",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant stomach neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "stomach cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca body - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "ca greater curvature of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, intestinal",
"description": ""
},
{
"id": "MIM:613659",
"resource": "MIM",
"url": "https://www.omim.org/entry/613659",
"name": "Gastric cancer",
"description": "Gastric cancer"
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Urinary bladder cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11054",
"evidence": [
{
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"id": "P05181",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05181"
}
],
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{
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"recommended_name": {
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},
"synonyms": [
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"url": "http://disease-ontology.org/term/DOID:11054",
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},
{
"id": "DOID:11054",
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"url": "http://disease-ontology.org/term/DOID:11054",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": "A primary or metastatic malignant neoplasm involving the bladder."
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
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"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "bladder cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "cancer of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumour",
"description": ""
},
{
"id": "MIM:109800",
"resource": "MIM",
"url": "https://www.omim.org/entry/109800",
"name": "Bladder cancer",
"description": "Bladder cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Head and neck cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11934",
"evidence": [
{
"database": "BioXpress",
"id": "P05181",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05181"
}
],
"disease": [
{
"disease_id": "DOID:11934",
"recommended_name": {
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck cancer",
"description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
},
"synonyms": [
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck tumours",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head/neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "tumor of head and neck",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Lung cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1324",
"evidence": [
{
"database": "BioXpress",
"id": "P05181",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05181"
}
],
"disease": [
{
"disease_id": "DOID:1324",
"recommended_name": {
"id": "DOID:1324",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1324",
"name": "lung cancer",
"description": "A respiratory system cancer that is located_in the lung."
},
"synonyms": [
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "LNCR1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "LNCR3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "adenocarcinoma of lung, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "LNCR4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "LNCR5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": "A malignant neoplasm involving the lung."
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "cancer of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung neoplasm",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumor",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumour",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung neoplasm",
"description": ""
},
{
"id": "MIM:211980",
"resource": "MIM",
"url": "https://www.omim.org/entry/211980",
"name": "Lung cancer",
"description": "Lung cancer"
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Breast cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1612",
"evidence": [
{
"database": "BioXpress",
"id": "P05181",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05181"
}
],
"disease": [
{
"disease_id": "DOID:1612",
"recommended_name": {
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast cancer",
"description": "A thoracic cancer that originates in the mammary gland."
},
"synonyms": [
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant neoplasm of breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant tumor of the breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary cancer",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "primary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, lobular, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of the breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial Male",
"description": ""
},
{
"id": "MIM:114480",
"resource": "MIM",
"url": "https://www.omim.org/entry/114480",
"name": "Breast cancer",
"description": "Breast cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Thyroid cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1781",
"evidence": [
{
"database": "BioXpress",
"id": "P05181",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05181"
}
],
"disease": [
{
"disease_id": "DOID:1781",
"recommended_name": {
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid cancer",
"description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
},
"synonyms": [
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid gland cancer",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "Thyroid gland neoplasm",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant tumour of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Kidney cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:263",
"evidence": [
{
"database": "BioXpress",
"id": "P05181",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05181"
}
],
"disease": [
{
"disease_id": "DOID:263",
"recommended_name": {
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "kidney cancer",
"description": "A urinary system cancer that is located_in the kidney."
},
"synonyms": [
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant neoplasm of kidney except pelvis",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant tumour of kidney",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "renal cancer",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Liver cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:3571",
"evidence": [
{
"database": "BioXpress",
"id": "P05181",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05181"
}
],
"disease": [
{
"disease_id": "DOID:3571",
"recommended_name": {
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "liver cancer",
"description": "A hepatobiliary system cancer that is located_in the liver."
},
"synonyms": [
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Ca liver - primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Resectable malignant neoplasm of Liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant hepato-biliary neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant tumor of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "non-resectable primary hepatic malignant neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary liver cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "resectable malignant neoplasm of the liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, not specified as primary or secondary",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Uterine cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:363",
"evidence": [
{
"database": "BioXpress",
"id": "P05181",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05181"
}
],
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Esophageal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:5041",
"evidence": [
{
"database": "BioXpress",
"id": "P05181",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05181"
}
],
"disease": [
{
"disease_id": "DOID:5041",
"recommended_name": {
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophageal cancer",
"description": "A gastrointestinal system cancer that is located_in the esophagus."
},
"synonyms": [
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophagus cancer",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Distal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Proximal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of the middle Third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": "A primary or metastatic malignant neoplasm involving the esophagus."
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "oesophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of lower third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of middle third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of proximal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of upper third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of distal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of proximal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of the middle third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of abdominal oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of distal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of proximal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of the middle third of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Aerodigestive tract cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Escc, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "gastric cardia adenocarcinoma, susceptibility to",
"description": ""
},
{
"id": "MIM:133239",
"resource": "MIM",
"url": "https://www.omim.org/entry/133239",
"name": "Esophageal cancer",
"description": "Esophageal cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Colorectal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:9256",
"evidence": [
{
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"id": "P05181",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05181"
}
],
"disease": [
{
"disease_id": "DOID:9256",
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"resource": "Disease Ontology",
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},
"synonyms": [
{
"id": "MONDO:0005575",
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"name": "colorectal cancer",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
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"name": "cancer of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large bowel",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
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"name": "cancer of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, advanced, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
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"name": "colon cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer with chromosomal instability, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
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"name": "colorectal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
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},
{
"id": "MONDO:0005575",
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"name": "colorectum cancer",
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},
{
"id": "MONDO:0005575",
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"name": "malignant colorectal neoplasm",
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},
{
"id": "MONDO:0005575",
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"name": "malignant colorectal tumor",
"description": ""
},
{
"id": "MONDO:0005575",
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"name": "malignant colorectal tumour",
"description": ""
},
{
"id": "MONDO:0005575",
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"name": "malignant colorectum neoplasm",
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},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel neoplasm",
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},
{
"id": "MONDO:0005575",
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"name": "malignant large bowel tumor",
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},
{
"id": "MONDO:0005575",
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"title": "Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells.",
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"name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen",
"id": "GO:0016712",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016712",
"evidence": [
{
"database": "UniProtKB",
"id": "P05181",
"url": "https://www.uniprot.org/uniprot/P05181"
}
],
"pmid": ""
},
{
"name": "arachidonic acid epoxygenase activity",
"id": "GO:0008392",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008392",
"evidence": [
{
"database": "UniProtKB",
"id": "P05181",
"url": "https://www.uniprot.org/uniprot/P05181"
}
],
"pmid": ""
},
{
"name": "oxygen binding",
"id": "GO:0019825",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019825",
"evidence": [
{
"database": "UniProtKB",
"id": "P05181",
"url": "https://www.uniprot.org/uniprot/P05181"
}
],
"pmid": ""
},
{
"name": "long-chain fatty acid omega-1 hydroxylase activity",
"id": "GO:0120319",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120319",
"evidence": [
{
"database": "UniProtKB",
"id": "P05181",
"url": "https://www.uniprot.org/uniprot/P05181"
}
],
"pmid": ""
},
{
"name": "4-nitrophenol 2-monooxygenase activity",
"id": "GO:0018601",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018601",
"evidence": [
{
"database": "UniProtKB",
"id": "P05181",
"url": "https://www.uniprot.org/uniprot/P05181"
}
],
"pmid": ""
}
]
},
{
"name": "Cellular Component",
"total": 4,
"go_terms": [
{
"name": "mitochondrial inner membrane",
"id": "GO:0005743",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743",
"evidence": [
{
"database": "UniProtKB",
"id": "P05181",
"url": "https://www.uniprot.org/uniprot/P05181"
}
],
"pmid": ""
},
{
"name": "endoplasmic reticulum membrane",
"id": "GO:0005789",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789",
"evidence": [
{
"database": "UniProtKB",
"id": "P05181",
"url": "https://www.uniprot.org/uniprot/P05181"
}
],
"pmid": ""
},
{
"name": "cytoplasm",
"id": "GO:0005737",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
"evidence": [
{
"database": "UniProtKB",
"id": "P05181",
"url": "https://www.uniprot.org/uniprot/P05181"
}
],
"pmid": ""
},
{
"name": "intracellular membrane-bounded organelle",
"id": "GO:0043231",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231",
"evidence": [
{
"database": "UniProtKB",
"id": "P05181",
"url": "https://www.uniprot.org/uniprot/P05181"
}
],
"pmid": ""
}
]
},
{
"name": "Biological Process",
"total": 14,
"go_terms": [
{
"name": "fatty acid metabolic process",
"id": "GO:0006631",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006631",
"evidence": [
{
"database": "UniProtKB",
"id": "P05181",
"url": "https://www.uniprot.org/uniprot/P05181"
}
],
"pmid": ""
},
{
"name": "lipid hydroxylation",
"id": "GO:0002933",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002933",
"evidence": [
{
"database": "UniProtKB",
"id": "P05181",
"url": "https://www.uniprot.org/uniprot/P05181"
}
],
"pmid": ""
},
{
"name": "monoterpenoid metabolic process",
"id": "GO:0016098",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016098",
"evidence": [
{
"database": "UniProtKB",
"id": "P05181",
"url": "https://www.uniprot.org/uniprot/P05181"
}
],
"pmid": ""
},
{
"name": "carbon tetrachloride metabolic process",
"id": "GO:0018885",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018885",
"evidence": [
{
"database": "UniProtKB",
"id": "P05181",
"url": "https://www.uniprot.org/uniprot/P05181"
}
],
"pmid": ""
},
{
"name": "benzene metabolic process",
"id": "GO:0018910",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018910",
"evidence": [
{
"database": "UniProtKB",
"id": "P05181",
"url": "https://www.uniprot.org/uniprot/P05181"
}
],
"pmid": ""
},
{
"name": "halogenated hydrocarbon metabolic process",
"id": "GO:0042197",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042197",
"evidence": [
{
"database": "UniProtKB",
"id": "P05181",
"url": "https://www.uniprot.org/uniprot/P05181"
}
],
"pmid": ""
},
{
"name": "heterocycle metabolic process",
"id": "GO:0046483",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046483",
"evidence": [
{
"database": "UniProtKB",
"id": "P05181",
"url": "https://www.uniprot.org/uniprot/P05181"
}
],
"pmid": ""
},
{
"name": "long-chain fatty acid metabolic process",
"id": "GO:0001676",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001676",
"evidence": [
{
"database": "UniProtKB",
"id": "P05181",
"url": "https://www.uniprot.org/uniprot/P05181"
}
],
"pmid": ""
},
{
"name": "response to bacterium",
"id": "GO:0009617",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009617",
"evidence": [
{
"database": "UniProtKB",
"id": "P05181",
"url": "https://www.uniprot.org/uniprot/P05181"
}
],
"pmid": ""
},
{
"name": "xenobiotic metabolic process",
"id": "GO:0006805",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006805",
"evidence": [
{
"database": "UniProtKB",
"id": "P05181",
"url": "https://www.uniprot.org/uniprot/P05181"
}
],
"pmid": ""
},
{
"name": "steroid metabolic process",
"id": "GO:0008202",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008202",
"evidence": [
{
"database": "UniProtKB",
"id": "P05181",
"url": "https://www.uniprot.org/uniprot/P05181"
}
],
"pmid": ""
},
{
"name": "long-chain fatty acid biosynthetic process",
"id": "GO:0042759",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042759",
"evidence": [
{
"database": "UniProtKB",
"id": "P05181",
"url": "https://www.uniprot.org/uniprot/P05181"
}
],
"pmid": ""
},
{
"name": "epoxygenase P450 pathway",
"id": "GO:0019373",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019373",
"evidence": [
{
"database": "UniProtKB",
"id": "P05181",
"url": "https://www.uniprot.org/uniprot/P05181"
}
],
"pmid": ""
},
{
"name": "4-nitrophenol metabolic process",
"id": "GO:0018960",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018960",
"evidence": [
{
"database": "UniProtKB",
"id": "P05181",
"url": "https://www.uniprot.org/uniprot/P05181"
}
],
"pmid": ""
}
]
}
]
},
"pro_annotation": [],
"site_annotation": [
{
"start_pos": 143,
"end_pos": 145,
"annotation": "n_glycosylation_sequon"
}
],
"ptm_annotation": [],
"interactions": [],
"reactions": [
{
"id": "17149",
"name": "",
"equation": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11711-1",
"P05182-1",
"A0A8I6A0P6-1",
"P10633-1",
"P51538-1",
"P00176-1",
"P05178-1",
"P10610-1",
"P13107-1",
"P20812-1",
"P33272-1",
"P51870-1",
"P00185-1",
"Q64581-1",
"P05179-1",
"P51871-1",
"P04167-1",
"P04800-1",
"P05183-1",
"P10634-1",
"P11510-1",
"P12938-1",
"P12939-1",
"P15129-1",
"P15149-1",
"P20814-1",
"P33273-1",
"P51590-1",
"Q64583-1",
"Q64680-1",
"P04799-1",
"Q64678-1",
"P08683-1",
"P24464-1",
"D4A820-1",
"A0A0G2K5K4-1",
"F1LT33-1",
"G3V9D2-1",
"Q9QXF7-1",
"A0A8I5ZZ08-1",
"P05181-1",
"A0A087X1C5-1",
"P08684-1",
"P20853-1",
"P04798-1",
"P05177-1",
"P33261-1",
"Q86W10-1",
"Q16678-1",
"P98187-1",
"P10632-1",
"P24462-1",
"Q9HB55-1",
"P13584-1",
"Q16696-1",
"Q9HCS2-1",
"P33260-1",
"Q02928-1",
"Q08477-1",
"Q9HBI6-1",
"P78329-1",
"P11712-1",
"P24903-1",
"P20815-1",
"Q6V0L0-1",
"P20852-1",
"O09158-1",
"O55071-1",
"Q64459-1",
"Q64481-1",
"O54749-1",
"P15392-1",
"Q8CIM7-1",
"P56654-1",
"P56655-1",
"P56656-1",
"P12791-1",
"P56593-1",
"O54750-1",
"Q91WL5-1",
"Q91X77-1",
"Q64458-1",
"P00186-1",
"P00184-1",
"Q6XVG2-1",
"Q9D816-1",
"P11714-1",
"P12790-1",
"P24457-1",
"Q9JMA7-1",
"P24456-1",
"Q64462-1",
"Q64464-1",
"Q05421-1",
"Q64429-1",
"D3YYZ0-1",
"D3Z2W7-1",
"B2RXZ2-1",
"Q9WV19-1",
"Q9DBX6-1",
"E9Q593-1",
"A2A974-1",
"A6H6J2-1",
"Q9EQW4-1",
"B2RXA7-1"
],
"evidence": [
{
"id": "17149",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/17149"
}
]
},
{
"id": "26205",
"name": "",
"equation": "4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+)",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P05182-1",
"P05181-1",
"Q05421-1"
],
"evidence": [
{
"id": "26205",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/26205"
}
]
},
{
"id": "39751",
"name": "",
"equation": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P05182-1",
"P08516-1",
"P05181-1",
"Q86W10-1",
"Q05421-1",
"Q91WL5-1",
"O88833-1",
"A2A974-1"
],
"evidence": [
{
"id": "39751",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/39751"
}
]
},
{
"id": "39787",
"name": "",
"equation": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P05182-1",
"P05181-1",
"P04798-1",
"P33261-1",
"Q08477-1",
"P00184-1",
"Q05421-1",
"Q91WL5-1",
"A2A974-1"
],
"evidence": [
{
"id": "39787",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/39787"
}
]
},
{
"id": "50076",
"name": "",
"equation": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P05182-1",
"P05181-1",
"P04798-1",
"P33261-1",
"P00184-1",
"Q05421-1"
],
"evidence": [
{
"id": "50076",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/50076"
}
]
},
{
"id": "50088",
"name": "",
"equation": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P05182-1",
"P05181-1",
"P33261-1",
"Q08477-1",
"Q05421-1"
],
"evidence": [
{
"id": "50088",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/50088"
}
]
},
{
"id": "50096",
"name": "",
"equation": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P05182-1",
"P05181-1",
"Q05421-1"
],
"evidence": [
{
"id": "50096",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/50096"
}
]
},
{
"id": "R-HSA-143468",
"name": "MEOS oxidizes ethanol to acetaldehyde",
"equation": "",
"summary": "The MEOS (microsomal ethanol oxidizing system) is an accessory pathway in the liver which increases in activity on chronic alcohol induction. The MEOS utilizes a cytochrome P450 which has since been deciphered to be CYP2E1, an ethanol-inducible form of P450. CYP2E1 also increases acetaldehyde formation and free radicals which can initiate lipid peroxidation. CYP2E1 can also activate many over-the-counter medicines and solvents to toxic metabolites and deplete retinoids resulting in their depletion and deletrious effects. This is because, being a cytochrome P450 and using NADPH and oxygen, it has the ability to biotransform drugs when it has been induced by ethanol.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-113748"
],
"output_participant_list": [
"R-ALL-113745"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P11509-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-143468",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-143468"
}
]
},
{
"id": "R-HSA-211881",
"name": "Coumarin is 7-hydroxylated by CYP2A13",
"equation": "",
"summary": "CYP2A13 can also 7-hydroxylate coumarin. It shares a 93.5% identity with CYP2A6 in the amino acid sequence but it is only about one-tenth as active as CYP2A6 in catalyzing coumarin 7-hydroxylation.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane, smooth endoplasmic reticulum",
"input_participant_list": [
"R-ALL-76328"
],
"output_participant_list": [
"R-ALL-76452"
],
"enzyme_list": [
"P05181-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P51589-1",
"P11509-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-211881",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211881"
}
]
},
{
"id": "R-HSA-211910",
"name": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation",
"equation": "",
"summary": "Paclitaxel (Taxol) is a naturally occurring member of the taxane family of antitumor drugs. It acts by stabilizing microtubules. Paclitaxel is inactivated in human liver by CYP2C8, which catalyzes 6alpha-hydroxylation of paclitaxel.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-211906"
],
"output_participant_list": [
"R-ALL-211894"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"P33260-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-211910",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211910"
}
]
},
{
"id": "R-HSA-211929",
"name": "CYP2C19 5-hydroxylates omeprazole",
"equation": "",
"summary": "Omeprazole is a potent long-acting inhibitor of gastric acid secretion by irreversible binding to the proton pump (H+,K+) ATPase in the gastric parietal cell. CYP2C19 is the major P450 which involved in 5-hydroxylation of omeprazole.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-211892"
],
"output_participant_list": [
"R-ALL-211944"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"P33260-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-211929",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211929"
}
]
},
{
"id": "R-HSA-211966",
"name": "CYP2D6 4-hydroxylates debrisoquine",
"equation": "",
"summary": "CYP2D6 (debrisoquine 4-hydroxylase) has a wide substrate specificity and is an important cytochrme P450 in drug metabolism. It has extensive genetic polymorphism (called the debrisoquine/sparteine oxidation polymorphism) that influences its expression and function.The polymorphism is responsible for populations being poor metabolizers (PM) or extensive metabolizers (EM, normal). Approximately 10% of Caucasians and less than 1% of Asians lack the CYP2D6 protein because of two null alleles which do not encode the functional product. Further polymorphisms discovered recently have identified ultrarapid metabolizers (PM) (alleles with multiple gene copies) and intermediate metabolizers (IM) (deficiency in their metabolism capacity) (Zanger UM et al, 2004).",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-211993"
],
"output_participant_list": [
"R-ALL-211952"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P33261-1",
"P51589-1",
"Q8TAV3-1",
"P10632-1",
"P11712-1"
],
"evidence": [
{
"id": "R-HSA-211966",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211966"
}
]
},
{
"id": "R-HSA-211988",
"name": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation",
"equation": "",
"summary": "Tolbutamide is an oral hypoglycemic agent whose action is terminated by hydroxylation of the tolylsulfonyl methyl moiety. The reaction is catalyzed by CYP2C9.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-9838902"
],
"output_participant_list": [
"R-ALL-211937"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"P33260-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-211988",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211988"
}
]
},
{
"id": "R-HSA-211991",
"name": "Cyclophosphamide is 4-hydroxylated by CYP2B6",
"equation": "",
"summary": "Cyclophosphamide (CPA) is an alkylating agent used in cancer chemotherapy and an immunosuppressant. CYP2B6 converts CPA to the active metabolite 4-hydroxy-CPA.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-211977"
],
"output_participant_list": [
"R-ALL-211967"
],
"enzyme_list": [
"P05181-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P51589-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-211991",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211991"
}
]
},
{
"id": "R-HSA-212005",
"name": "CYP2F1 dehydrogenates 3-methylindole",
"equation": "",
"summary": "3-methylindole (3MI) is a fermentation product of tryptophan. It is usually formed in the rumen of goats and cattle and in the large intestine of humans. CYP2F1 shows the highest activity towards the dehydrogenation of 3MI to form a methylene imine-reactive intermediate.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-213162"
],
"output_participant_list": [
"R-ALL-213163"
],
"enzyme_list": [
"P05181-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P51589-1",
"P11509-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-212005",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-212005"
}
]
},
{
"id": "R-HSA-76354",
"name": "Vinyl chloride is oxidized to 2-Chloroethylene oxide",
"equation": "",
"summary": "CYP2E1 can catalyze the oxidation of the vinyl halide vinyl chloride to the epoxide 2-chloroethylene oxide. The epoxide is very unstable and rearranges quickly to 2-chloroacetaldehyde. Both these products can interact with DNA and proteins.",
"cellular_location": "smooth endoplasmic reticulum",
"input_participant_list": [
"R-ALL-39417"
],
"output_participant_list": [
"R-ALL-156524"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P11509-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-76354",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76354"
}
]
},
{
"id": "R-HSA-76397",
"name": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)",
"equation": "",
"summary": "N-acetyl-p-benzoquinone imine (NAPQI) is the reactive intermediate of the analgesic and antipyretic, acetaminophen (INN, paracetamol). At usual doses, NAPQI is quickly detoxified by conjugation but in overdose situations, NAPQI is extremely toxic to liver tissue.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-113555",
"R-ALL-113564",
"R-ALL-39427"
],
"output_participant_list": [
"R-ALL-76396"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P11509-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-76397",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76397"
}
]
},
{
"id": "R-HSA-76416",
"name": "Benzene is hydroxylated to phenol",
"equation": "",
"summary": "Benzene is an occupational and environmental toxicant and is implicated in myelogenous leukemia. For toxicity to occur, benzene is oxidised to phenol and subsequently to catechol and hydroquinone. CYP2E1 is the enzyme responsible for oxidation of benzene to phenol.",
"cellular_location": "smooth endoplasmic reticulum",
"input_participant_list": [
"R-ALL-31711"
],
"output_participant_list": [
"R-ALL-29630"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P11509-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-76416",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76416"
}
]
},
{
"id": "R-HSA-76434",
"name": "Dehalogenation of carbon tetrachloride to form a free radical",
"equation": "",
"summary": "Carbon tetrachloride (CCl4) has been widely used as a dry-cleaning agent, in fire extinguishers and in the manufacture of other halogenated hydrocarbons. At toxic doses, CCl4 exposure can damage the liver and kidneys. This toxicity results from CYP2E1-dependant reduction of CCl4 to the reactive trichloromethyl radical (CCl3.).",
"cellular_location": "smooth endoplasmic reticulum",
"input_participant_list": [
"R-ALL-40887"
],
"output_participant_list": [
"R-ALL-29572",
"R-ALL-76433"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P11509-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-76434",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76434"
}
]
},
{
"id": "R-HSA-76453",
"name": "Coumarin is 7-hydroxylated by CYP2A6",
"equation": "",
"summary": "The 7-hydroxylation of coumarin is used as an assay of P450 activity in animal and human liver microsomes. CYP2A6 is the major coumarin 7-hydroxylase in human liver.",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane, smooth endoplasmic reticulum",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P05181-1",
"P20853-1",
"P11509-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-76453",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76453"
}
]
},
{
"id": "R-HSA-76456",
"name": "O-atom dealkylation of dextromethorphan",
"equation": "",
"summary": "At the beginning of this reaction, 1 molecule of 'H+', 1 molecule of 'Dextromethorphan', 1 molecule of 'Oxygen', and 1 molecule of 'NADPH' are present. At the end of this reaction, 1 molecule of 'NADP+', 1 molecule of 'Dextrorphan', 1 molecule of 'Formaldehyde', and 1 molecule of 'H2O' are present.
This reaction takes place in the 'smooth endoplasmic reticulum' and is mediated by the 'oxygen binding activity' of 'Cytochrome P450 2D6 '.
",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane, smooth endoplasmic reticulum",
"input_participant_list": [
"R-ALL-39703"
],
"output_participant_list": [
"R-ALL-76455"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P33261-1",
"P51589-1",
"Q8TAV3-1",
"P10632-1",
"P11712-1"
],
"evidence": [
{
"id": "R-HSA-76456",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76456"
}
]
},
{
"id": "R-HSA-76475",
"name": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide",
"equation": "",
"summary": "The volatile anesthetic halothane can undergo CYP2E1-catalyzed oxidation to form a reactive intermediate which can acetylate liver proteins. These proteins can then stimulate an immune reaction that mediates severe hepatic necrosis (\\halothane hepatitis\\).",
"cellular_location": "smooth endoplasmic reticulum",
"input_participant_list": [
"R-ALL-40795"
],
"output_participant_list": [
"R-ALL-76473",
"R-ALL-76474"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P20813-1",
"P20853-1",
"P33261-1",
"P11509-1",
"Q96SQ9-1",
"P10632-1",
"P11712-1",
"P24903-1",
"Q16696-1"
],
"evidence": [
{
"id": "R-HSA-76475",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76475"
}
]
},
{
"id": "R-HSA-9027043",
"name": "CYPs hydroxylate DHA to 14(R)-HDHA",
"equation": "",
"summary": "Using human leukocytes and platelets, Hong et al. found that incubating docosahexaenoic acid (DHA) with a mixture of human cytochrome P450 enzymes (CYP1A2, 2C8, 2C9, 2D6, 2E1 and 3A4) formed 14(R)-hydroxy-docsosahexaenoic acid (14(R)-HDHA), the precursor to maresin-like mediator 2 (MaR-L2) (Hong et al. 2014). There is no data to indicate which one or ones of these CYPs mediate this event under physiological conditions. CYP inhibition diminishes the formation of 14(R)-HDHA, confirming CYP determines 14(R)-hydroxylation (Hong et al. 2014). The CYP mixture also formed 22-hydroxy-docosahexaenoic acid (22-HDHA) by \u03c9-oxidation (not shown here). Although the CYP mixture also catalysed the formation of 14(S)-HDHA, the amount formed is minor compared to that formed by 12-lipoxygenase (Hong et al. 2014).",
"cellular_location": "cytosol, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-9024011"
],
"output_participant_list": [],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P10632-1",
"P11712-1",
"P05177-1",
"P08684-1"
],
"evidence": [
{
"id": "R-HSA-9027043",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9027043"
}
]
},
{
"id": "R-HSA-9027302",
"name": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA",
"equation": "",
"summary": "In macrophages, cytochrome P450s (CYPs) are likely to 21-hydroxylate 14(S)-hydroxy-docosahexaenoic acid (14(S)-HDHA) to 14(S),21(R)-dihydroxy-docosahexaenoic acid (14(S),21(R)-diHDHA) and 14(S),21(S)-diHDHA (Lu et al. 2010, Tian et al. 2011a, 2011b). In human skin, CYP1A1, 2B6/7, 2E1, 3A4/7 and 3A5 proteins have been identified and shown to possess catalytic activities (Swanson 2004). CYP2E1 is able to generate 19-hydroxyleicosatetraenoic acid, an \u03c9-1 hydroxylation intermediate of arachidonic acid (Laethem et al. 1993) therefore, it might also \u03c9-1 hydroxylate 14(S)-HDHA in human skin.
14(S),21(R)-diHDHA was shown to counteract the diabetic impairment of macrophage pro-healing functions in an autocrine/paracrine fashion, enhancing wound healing (Lu et al. 2010, Tian et al. 2011a, 2011b).",
"cellular_location": "cytosol, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-9027029"
],
"output_participant_list": [],
"enzyme_list": [
"P05181-1"
],
"evidence": [
{
"id": "R-HSA-9027302",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9027302"
}
]
},
{
"id": "R-HSA-9027321",
"name": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA",
"equation": "",
"summary": "In macrophages, cytochrome P450s (CYPs) are likely to 21-hydroxylate 14(R)-hydroxy-docosahexaenoic acid (14(R)-HDHA) to 14(R),21(R)-dihydroxy-docosahexaenoic acid (14(R),21(R)-diHDHA) and 14(R),21(S)-diHDHA (Lu et al. 2010). In human skin, CYP1A1, 2B6/7, 2E1, 3A4/7, and 3A5 proteins have been identified and shown to possess catalytic activities (Swanson 2004). CYP2E1 is able to generate 19-hydroxyleicosatetraenoic acid, an \u03c9-1 hydroxylation intermediate of arachidonic acid (Laethem et al. 1993) therefore, it might also \u03c9-1 hydroxylate 14(R)-HDHA in human skin.
Administration of 14,21-diHDHA stereoisomers to splinted excisional wounded mice demonstrated their involvement in wound pro-healing processes (Lu et al. 2010).",
"cellular_location": "cytosol, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-9027049"
],
"output_participant_list": [],
"enzyme_list": [
"P05181-1"
],
"evidence": [
{
"id": "R-HSA-9027321",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9027321"
}
]
},
{
"id": "R-HSA-9749986",
"name": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA",
"equation": "",
"summary": "2,3-Dihydroxybenzoate (2,3-DHBA) is a minor oxidation product of salicylate (ST). The reaction is catalyzed by several CYP2 and CYP3 cytochromes in the ER of hepatocytes (Grootveld & Halliwell, 1988; Bojic et al, 2015)",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [],
"output_participant_list": [
"R-ALL-9750011"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P33261-1",
"P10632-1",
"P11712-1",
"P08684-1"
],
"evidence": [
{
"id": "R-HSA-9749986",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9749986"
}
]
},
{
"id": "R-HSA-9750016",
"name": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA",
"equation": "",
"summary": "2,5-Dihydroxybenzoate (gentisic acid, 2,5-DHBA) is a minor oxidation product of salicylate (ST). The reaction is catalyzed by several CYP2 and CYP3 cytochromes in the ER of hepatocytes (Grootveld & Halliwell, 1988; Bojic et al, 2015).",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [],
"output_participant_list": [
"R-ALL-9750014"
],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P33261-1",
"P10632-1",
"P11712-1",
"P08684-1"
],
"evidence": [
{
"id": "R-HSA-9750016",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9750016"
}
]
},
{
"id": "R-HSA-9753285",
"name": "CYP2E1 monooxygenates APAP to NAPQI",
"equation": "",
"summary": "A small percentage (5-15%) of acetaminophen (APAP) is converted to the reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI) primarily by cytochrome P450 CYP2E1 (Manyike et al. 2000). Other P450s such as CYP1A2 and CYP3A4 may also be capable of mediating this transformation (Thummel et al. 1993, Zaher et al. 1998). In human volunteers, increasing therapeutic doses of APAP were found to increase the turnover of glutathione (GSH) (Lauterburg & Mitchell 1987) and APAP-protein adducts could be measured from APAP overdose patients (Davern et al. 2006). Cysteine residues in proteins are the major targets for covalent modification by NAPQI, the primary cause of APAP-induced hepatotoxicity (Streeter et al. 1984). APAP-induced hepatotoxicity occurs when APAP is taken as an acute oral dose exceeding 150 mg/kg in children and 7.5 grams in adults within 24 hours. Acutely increased levels of APAP saturates Phase II glucuronidation and sulfation detoxification pathways in the liver, shifting APAP to Phase I oxidation and producing high levels of NAPQI. Excess NAPQI overwhelms the glutathione conjugation pathway leading to glutathione store depletion in the liver. Excess NAPQI leads to increased oxidative stress with the formation of toxic free radicals which bind to cellular proteins forming APAP protein adducts leading to DNA fragmentation, especially in the mitochondria (Yoon et al. 2016).
The antituberculosis drug isoniazid can induce CYP2E1, which increases APAP oxidation, promotes GSH depletion and NAPQI formation and ultimately leads to increased hepatotoxicity (Epstein et al. 1991, Zand et al. 1993).",
"cellular_location": "cytosol, endoplasmic reticulum membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P05181-1"
],
"evidence": [
{
"id": "R-HSA-9753285",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9753285"
}
]
}
],
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"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P00184",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00184"
}
]
}
]
},
{
"uniprot_ac": "P00185",
"gene_name": "Cyp1a1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P00185",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00185"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "P00185",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00185"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P00185",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00185"
}
]
}
]
},
{
"uniprot_ac": "P00186",
"gene_name": "Cyp1a2",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P00186",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00186"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "P00186",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00186"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P00186",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00186"
}
]
}
]
},
{
"uniprot_ac": "P04167",
"gene_name": "Cyp2b2",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P04167",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04167"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P04167",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04167"
}
]
}
]
},
{
"uniprot_ac": "P04798",
"gene_name": "CYP1A1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P04798",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04798"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "P04798",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04798"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P04798",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04798"
}
]
}
]
},
{
"uniprot_ac": "P04799",
"gene_name": "Cyp1a2",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P04799",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04799"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P04799",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04799"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "P04799",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04799"
}
]
}
]
},
{
"uniprot_ac": "P04800",
"gene_name": "Cyp3a1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P04800",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04800"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P04800",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04800"
}
]
},
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P04800",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04800"
}
]
}
]
},
{
"uniprot_ac": "P05177",
"gene_name": "CYP1A2",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P05177",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05177"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "P05177",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05177"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P05177",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05177"
}
]
}
]
},
{
"uniprot_ac": "P05178",
"gene_name": "Cyp2c6",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P05178",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05178"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P05178",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05178"
}
]
}
]
},
{
"uniprot_ac": "P05179",
"gene_name": "Cyp2c7",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P05179",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05179"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P05179",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05179"
}
]
}
]
},
{
"uniprot_ac": "P05181",
"gene_name": "CYP2E1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P05181",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05181"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P05181",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05181"
}
]
},
{
"ec_number": "1.14.13.n7",
"activity": "4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+).",
"evidence": [
{
"id": "P05181",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05181"
}
]
},
{
"ec_number": "1.14.13.n7",
"activity": "",
"evidence": [
{
"id": "P05181",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05181"
}
]
}
]
},
{
"uniprot_ac": "P05182",
"gene_name": "Cyp2e1",
"activity": [
{
"ec_number": "1.14.13.n7",
"activity": "4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+).",
"evidence": [
{
"id": "P05182",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05182"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P05182",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05182"
}
]
},
{
"ec_number": "1.14.13.n7",
"activity": "",
"evidence": [
{
"id": "P05182",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05182"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P05182",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05182"
}
]
}
]
},
{
"uniprot_ac": "P05183",
"gene_name": "Cyp3a2",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P05183",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05183"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P05183",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05183"
}
]
}
]
},
{
"uniprot_ac": "P08516",
"gene_name": "Cyp4a10",
"activity": [
{
"ec_number": "1.14.14.80",
"activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P08516",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08516"
}
]
}
]
},
{
"uniprot_ac": "P08683",
"gene_name": "Cyp2c11",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P08683",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08683"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P08683",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08683"
}
]
}
]
},
{
"uniprot_ac": "P08684",
"gene_name": "CYP3A4",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P08684",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08684"
}
]
},
{
"ec_number": "1.14.14.55",
"activity": "O2 + quinine + reduced [NADPH--hemoprotein reductase] = 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P08684",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08684"
}
]
},
{
"ec_number": "1.14.14.56",
"activity": "1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] = 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P08684",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08684"
}
]
},
{
"ec_number": "1.14.14.73",
"activity": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P08684",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08684"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P08684",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08684"
}
]
},
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P08684",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08684"
}
]
}
]
},
{
"uniprot_ac": "P10610",
"gene_name": "Cyp2g1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P10610",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10610"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P10610",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10610"
}
]
}
]
},
{
"uniprot_ac": "P10632",
"gene_name": "CYP2C8",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P10632",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10632"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P10632",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10632"
}
]
}
]
},
{
"uniprot_ac": "P10633",
"gene_name": "Cyp2d1",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P10633",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10633"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P10633",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10633"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P10633",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10633"
}
]
}
]
},
{
"uniprot_ac": "P10634",
"gene_name": "Cyp2d26",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P10634",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10634"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P10634",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10634"
}
]
}
]
},
{
"uniprot_ac": "P10635",
"gene_name": "CYP2D6",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P10635",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10635"
}
]
}
]
},
{
"uniprot_ac": "P11509",
"gene_name": "CYP2A6",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P11509",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11509"
}
]
}
]
},
{
"uniprot_ac": "P11510",
"gene_name": "Cyp2c12",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P11510",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11510"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P11510",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11510"
}
]
}
]
},
{
"uniprot_ac": "P11711",
"gene_name": "Cyp2a1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P11711",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11711"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P11711",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11711"
}
]
}
]
},
{
"uniprot_ac": "P11712",
"gene_name": "CYP2C9",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P11712",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11712"
}
]
},
{
"ec_number": "1.14.14.51",
"activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P11712",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11712"
}
]
},
{
"ec_number": "1.14.14.52",
"activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P11712",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11712"
}
]
},
{
"ec_number": "1.14.14.53",
"activity": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P11712",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11712"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P11712",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11712"
}
]
}
]
},
{
"uniprot_ac": "P11714",
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}
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}
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]
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{
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]
}
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}
]
},
{
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"id": "P33272",
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]
}
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},
{
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}
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{
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]
},
{
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]
}
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},
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{
"ec_number": "1.14.14.-",
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"id": "P51589",
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]
},
{
"ec_number": "5.4.4.7",
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]
},
{
"ec_number": "1.14.14.73",
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{
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}
]
},
{
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{
"id": "P51589",
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}
]
}
]
},
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"ec_number": "1.14.14.1",
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{
"id": "P51590",
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]
},
{
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"id": "P51590",
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"url": "https://www.uniprot.org/uniprot/P51590"
}
]
}
]
},
{
"uniprot_ac": "P51870",
"gene_name": "Cyp4f5",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P51870",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51870"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P51870",
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}
]
}
]
},
{
"uniprot_ac": "P51871",
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P51871",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51871"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P51871",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51871"
}
]
}
]
},
{
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"gene_name": "Cyp2a12",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P56593",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56593"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P56593",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56593"
}
]
}
]
},
{
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"gene_name": "Cyp2c37",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "P56654",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56654"
}
]
},
{
"ec_number": "1.14.14.1",
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"evidence": [
{
"id": "P56654",
"database": "UniProtKB",
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}
]
}
]
},
{
"uniprot_ac": "P56655",
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "P56655",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56655"
}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "P56655",
"database": "UniProtKB",
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}
]
}
]
},
{
"uniprot_ac": "P56656",
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "P56656",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56656"
}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "P56656",
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"url": "https://www.uniprot.org/uniprot/P56656"
}
]
}
]
},
{
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"gene_name": "CYP4F2",
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "P78329",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78329"
}
]
},
{
"ec_number": "1.14.14.78",
"activity": "O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P78329",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78329"
}
]
},
{
"ec_number": "1.14.14.79",
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{
"id": "P78329",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78329"
}
]
},
{
"ec_number": "1.14.14.94",
"activity": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P78329",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78329"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
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{
"id": "P78329",
"database": "UniProtKB",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "P98187",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P98187"
}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "P98187",
"database": "UniProtKB",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
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{
"id": "Q02928",
"database": "UniProtKB",
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}
]
},
{
"ec_number": "1.14.14.80",
"activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q02928",
"database": "UniProtKB",
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}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "Q02928",
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}
]
}
]
},
{
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{
"id": "Q05421",
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}
]
},
{
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{
"id": "Q05421",
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}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "Q05421",
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}
]
},
{
"ec_number": "1.14.13.n7",
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{
"id": "Q05421",
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}
]
}
]
},
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{
"ec_number": "1.14.14.1",
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{
"id": "Q08477",
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}
]
},
{
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{
"id": "Q08477",
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}
]
},
{
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{
"id": "Q08477",
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}
]
},
{
"ec_number": "1.14.14.1",
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}
]
}
]
},
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{
"ec_number": "1.14.14.1",
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{
"id": "Q16678",
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}
]
},
{
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{
"id": "Q16678",
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}
]
},
{
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{
"id": "Q16678",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q16696",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16696"
}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "Q16696",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q64429",
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}
]
},
{
"ec_number": "4.2.1.152",
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{
"id": "Q64429",
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}
]
},
{
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{
"id": "Q64429",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q64458",
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}
]
},
{
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{
"id": "Q64458",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q64459",
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}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "Q64459",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q64462",
"database": "UniProtKB",
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}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "Q64462",
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}
]
}
]
},
{
"uniprot_ac": "Q64464",
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q64464",
"database": "UniProtKB",
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}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "Q64464",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q64481",
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}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "Q64481",
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}
]
}
]
},
{
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{
"ec_number": "1.14.14.-",
"activity": "",
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{
"id": "Q64581",
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}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "Q64581",
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}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "Q64581",
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}
]
}
]
},
{
"uniprot_ac": "Q64583",
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q64583",
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}
]
},
{
"ec_number": "1.14.14.1",
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{
"id": "Q64583",
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}
]
}
]
},
{
"uniprot_ac": "Q64678",
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q64678",
"database": "UniProtKB",
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}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
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{
"id": "Q64678",
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"url": "https://www.uniprot.org/uniprot/Q64678"
}
]
},
{
"ec_number": "1.14.14.1",
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"evidence": [
{
"id": "Q64678",
"database": "UniProtKB",
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}
]
}
]
},
{
"uniprot_ac": "Q64680",
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q64680",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64680"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q64680",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64680"
}
]
}
]
},
{
"uniprot_ac": "Q6V0L0",
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q6V0L0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6V0L0"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
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{
"id": "Q6V0L0",
"database": "UniProtKB",
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}
]
}
]
},
{
"uniprot_ac": "Q6XVG2",
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{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
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{
"id": "Q6XVG2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6XVG2"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q6XVG2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6XVG2"
}
]
}
]
},
{
"uniprot_ac": "Q86W10",
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}
]
},
{
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{
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{
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}
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}
]
},
{
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}
]
},
{
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}
]
}
]
},
{
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}
]
}
]
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{
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{
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},
{
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}
]
}
]
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{
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{
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{
"id": "Q91X77",
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}
]
},
{
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{
"id": "Q91X77",
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}
]
}
]
},
{
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{
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}
]
},
{
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]
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{
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}
]
}
]
},
{
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{
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{
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]
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]
},
{
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]
},
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