{
"uniprot_canonical_ac": "P00742-1",
"uniprot_ac": "P00742",
"uniprot_id": "FA10_HUMAN",
"mass": {
"chemical_mass": 54732.0,
"monoisotopic_mass": 54732.0
},
"refseq": {
"ac": "NP_000495",
"name": "coagulation factor X isoform 1 preproprotein",
"summary": "This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015].",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000495"
},
"gene_names": [
{
"name": "F10",
"resource": "UniProtKB",
"type": "recommended",
"url": "https://www.uniprot.org/uniprot/P00742",
"id": "P00742"
},
{
"name": "F10",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000495",
"id": "NP_000495"
},
{
"name": "FX; FXA",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000495",
"id": "NP_000495"
}
],
"protein_names": [
{
"name": "Coagulation factor X",
"resource": "UniProtKB",
"type": "recommended",
"url": "",
"id": "P00742"
},
{
"name": "3.4.21.6",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P00742"
},
{
"name": "Stuart factor",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P00742"
},
{
"name": "Stuart-Prower factor",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P00742"
},
{
"name": "coagulation factor X isoform 1 preproprotein",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000495",
"id": "NP_000495"
},
{
"name": "prothrombinase; factor Xa; Stuart-Prower factor",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000495",
"id": "NP_000495"
}
],
"function": [
{
"annotation": "Factor Xa cleaves SARS-CoV-2 spike protein to block viral entry and infection. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000495",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000495"
},
{
"database": "PubMed",
"id": "37024459",
"url": "https://glygen.org/publication/PubMed/37024459"
}
]
},
{
"annotation": "Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.",
"evidence": [
{
"database": "UniProtKB",
"id": "F8WBM7",
"url": "https://www.uniprot.org/uniprot/F8WBM7#function"
},
{
"database": "UniProtKB",
"id": "ARBA00037158",
"url": "https://www.uniprot.org/uniprot/ARBA00037158#function"
},
{
"database": "UniProtKB",
"id": "B7ZBK1",
"url": "https://www.uniprot.org/uniprot/B7ZBK1#function"
},
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742#function"
},
{
"database": "UniProtKB",
"id": "Q5JVE8",
"url": "https://www.uniprot.org/uniprot/Q5JVE8#function"
}
]
},
{
"annotation": "Five new F10 variants in hereditary factor x deficiency detected by high-throughput sequencing.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000495",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000495"
},
{
"database": "PubMed",
"id": "37842794",
"url": "https://glygen.org/publication/PubMed/37842794"
}
]
},
{
"annotation": "Influence of Heparan Sulfate Proteoglycans and Factor X on species D Human Adenovirus Uptake and Transduction. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000495",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000495"
},
{
"database": "PubMed",
"id": "36680095",
"url": "https://glygen.org/publication/PubMed/36680095"
}
]
},
{
"annotation": "Spike Protein Subunits of SARS-CoV-2 Alter Mitochondrial Metabolism in Human Pulmonary Microvascular Endothelial Cells: Involvement of Factor Xa. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000495",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000495"
},
{
"database": "PubMed",
"id": "36438904",
"url": "https://glygen.org/publication/PubMed/36438904"
}
]
},
{
"annotation": "This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015].",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000495",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000495"
}
]
}
],
"disease": [
{
"disease_id": "DOID:2222",
"recommended_name": {
"id": "DOID:2222",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:2222",
"name": "factor X deficiency",
"description": "A blood coagulation disease that is characterized by the partial or complete absence of factor X activity in the blood."
},
"synonyms": [
{
"id": "DOID:2222",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:2222",
"name": "disease, Stuart-Prower",
"description": ""
},
{
"id": "MONDO:0009212",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0009212",
"name": "congenital factor X deficiency",
"description": "Congenital factor X deficiency is an inherited bleeding disorder with a decreased antigen and/or activity of factor X (FX) and characterized by mild to severe bleeding symptoms."
},
{
"id": "MONDO:0009212",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0009212",
"name": "Stuart-Prower factor deficiency",
"description": ""
},
{
"id": "MONDO:0009212",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0009212",
"name": "congenital Stuart factor deficiency",
"description": ""
},
{
"id": "MONDO:0009212",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0009212",
"name": "congenital factor X deficiency",
"description": ""
},
{
"id": "MONDO:0009212",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0009212",
"name": "disease, Stuart-Prower",
"description": ""
},
{
"id": "MONDO:0009212",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0009212",
"name": "hereditary Factor X deficiency",
"description": ""
},
{
"id": "MONDO:0009212",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0009212",
"name": "F10 deficiency",
"description": ""
},
{
"id": "MONDO:0009212",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0009212",
"name": "Stuart factor deficiency, congenital",
"description": ""
},
{
"id": "MONDO:0009212",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0009212",
"name": "Stuart-Prower Factor deficiency",
"description": ""
},
{
"id": "MONDO:0009212",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0009212",
"name": "factor 10 deficiency",
"description": ""
},
{
"id": "MONDO:0009212",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0009212",
"name": "factor X deficiency",
"description": ""
},
{
"id": "MONDO:0009212",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0009212",
"name": "factor X deficiency, congenital",
"description": ""
},
{
"id": "MIM:227600",
"resource": "MIM",
"url": "https://www.omim.org/entry/227600",
"name": "Factor X deficiency",
"description": "Factor X deficiency"
}
],
"evidence": [
{
"id": "227600",
"database": "MIM",
"url": "https://www.omim.org/entry/227600"
}
]
}
],
"snv": [
{
"evidence": [
{
"id": "P00742",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P00742"
}
],
"glycoeffect": [],
"start_pos": 117,
"end_pos": 117,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "E",
"sequence_mut": "K",
"comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).",
"chr_id": "13",
"chr_pos": "113139449",
"ref_nt": "G",
"alt_nt": "A",
"minor_allelic_frequency": "",
"site_lbl": "E117",
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
},
{
"disease_id": "DOID:9256",
"recommended_name": {
"id": "DOID:9256",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:9256",
"name": "colorectal cancer",
"description": "A large intestine cancer that is located_in the colon and/or located_in the rectum."
},
"synonyms": [
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma."
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, advanced, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer with chromosomal instability, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectum cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectum neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "CRC",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "large intestine cancer",
"description": ""
},
{
"id": "MIM:114500",
"resource": "MIM",
"url": "https://www.omim.org/entry/114500",
"name": "Colorectal cancer",
"description": "Colorectal cancer"
}
]
},
{
"disease_id": "DOID:10534",
"recommended_name": {
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "stomach cancer",
"description": "A gastrointestinal system cancer that is located_in the stomach."
},
"synonyms": [
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric cancer",
"description": ""
},
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": "A primary or metastatic malignant neoplasm involving the stomach."
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca lesser curvature - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "cancer of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer risk after h. pylori infection",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumor",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumour",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant stomach neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "stomach cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca body - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "ca greater curvature of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, intestinal",
"description": ""
},
{
"id": "MIM:613659",
"resource": "MIM",
"url": "https://www.omim.org/entry/613659",
"name": "Gastric cancer",
"description": "Gastric cancer"
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease"
]
},
{
"evidence": [
{
"id": "P00742",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P00742"
}
],
"glycoeffect": [
"o-glyco-site-loss"
],
"start_pos": 190,
"end_pos": 190,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "S",
"sequence_mut": "R",
"comment": "Somatic mutation passed 1 out of 6 filters: o-glyco-site-loss (S->R).",
"chr_id": "13",
"chr_pos": "113143918",
"ref_nt": "C",
"alt_nt": "A",
"minor_allelic_frequency": "",
"site_lbl": "S190",
"disease": [
{
"disease_id": "DOID:1324",
"recommended_name": {
"id": "DOID:1324",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1324",
"name": "lung cancer",
"description": "A respiratory system cancer that is located_in the lung."
},
"synonyms": [
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "LNCR1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "LNCR3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "adenocarcinoma of lung, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "LNCR4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "LNCR5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": "A malignant neoplasm involving the lung."
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "cancer of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung neoplasm",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumor",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumour",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung neoplasm",
"description": ""
},
{
"id": "MIM:211980",
"resource": "MIM",
"url": "https://www.omim.org/entry/211980",
"name": "Lung cancer",
"description": "Lung cancer"
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease"
]
},
{
"evidence": [
{
"id": "rs1368140210",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1368140210"
},
{
"id": "rs1368140210",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs1368140210#frequency_tab"
},
{
"id": "rs1368140210",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs1368140210"
}
],
"glycoeffect": [
"o-glyco-site-loss"
],
"start_pos": 199,
"end_pos": 199,
"sequence_org": "T",
"sequence_mut": "I",
"comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->I).",
"chr_id": "13",
"chr_pos": "113143944",
"ref_nt": "T",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "T199",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "P00742",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P00742"
}
],
"glycoeffect": [
"n-glyco-sequon-loss"
],
"start_pos": 221,
"end_pos": 221,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "N",
"sequence_mut": "S",
"comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-loss (NQT->SQT).",
"chr_id": "13",
"chr_pos": "113144010",
"ref_nt": "A",
"alt_nt": "G",
"minor_allelic_frequency": "",
"site_lbl": "N221",
"disease": [
{
"disease_id": "DOID:1324",
"recommended_name": {
"id": "DOID:1324",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1324",
"name": "lung cancer",
"description": "A respiratory system cancer that is located_in the lung."
},
"synonyms": [
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "LNCR1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "LNCR3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "adenocarcinoma of lung, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "LNCR4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "LNCR5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": "A malignant neoplasm involving the lung."
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "cancer of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung neoplasm",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumor",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumour",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung neoplasm",
"description": ""
},
{
"id": "MIM:211980",
"resource": "MIM",
"url": "https://www.omim.org/entry/211980",
"name": "Lung cancer",
"description": "Lung cancer"
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease"
]
},
{
"evidence": [
{
"id": "rs1229459471",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1229459471"
},
{
"id": "rs1229459471",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs1229459471"
}
],
"glycoeffect": [
"n-glyco-sequon-loss",
"o-glyco-site-loss"
],
"start_pos": 223,
"end_pos": 223,
"sequence_org": "T",
"sequence_mut": "A",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NQT->NQA).",
"chr_id": "13",
"chr_pos": "113144015",
"ref_nt": "G",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "T223",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "P00742",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P00742"
},
{
"id": "rs566300775",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs566300775"
},
{
"id": "rs566300775",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs566300775"
},
{
"id": "rs566300775",
"database": "NCI-TCGA",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs566300775"
},
{
"id": "rs566300775",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs566300775#frequency_tab"
},
{
"id": "rs566300775",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs566300775"
}
],
"glycoeffect": [
"n-glyco-sequon-loss",
"o-glyco-site-loss"
],
"start_pos": 223,
"end_pos": 223,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "T",
"sequence_mut": "M",
"comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-loss (NQT->NQM).",
"chr_id": "13",
"chr_pos": "113144016",
"ref_nt": "C",
"alt_nt": "T",
"minor_allelic_frequency": "",
"site_lbl": "T223",
"disease": [
{
"disease_id": "DOID:9256",
"recommended_name": {
"id": "DOID:9256",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:9256",
"name": "colorectal cancer",
"description": "A large intestine cancer that is located_in the colon and/or located_in the rectum."
},
"synonyms": [
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma."
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, advanced, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer with chromosomal instability, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectum cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectum neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "CRC",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "large intestine cancer",
"description": ""
},
{
"id": "MIM:114500",
"resource": "MIM",
"url": "https://www.omim.org/entry/114500",
"name": "Colorectal cancer",
"description": "Colorectal cancer"
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease",
"ebi"
]
},
{
"evidence": [
{
"id": "P00742",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P00742"
}
],
"glycoeffect": [
"n-glyco-sequon-loss",
"o-glyco-site-loss"
],
"start_pos": 223,
"end_pos": 223,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "T",
"sequence_mut": "P",
"comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-loss (NQT->NQP).",
"chr_id": "13",
"chr_pos": "113144015",
"ref_nt": "A",
"alt_nt": "C",
"minor_allelic_frequency": "",
"site_lbl": "T223",
"disease": [
{
"disease_id": "DOID:4159",
"recommended_name": {
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "skin cancer",
"description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells."
},
"synonyms": [
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "CA - skin cancer",
"description": ""
},
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "malignant neoplasm of skin",
"description": ""
},
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "melanoma and Non-melanoma skin cancer",
"description": ""
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease"
]
},
{
"evidence": [
{
"id": "rs566300775",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs566300775"
},
{
"id": "rs566300775",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs566300775"
},
{
"id": "rs566300775",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs566300775#frequency_tab"
},
{
"id": "rs566300775",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs566300775"
}
],
"glycoeffect": [
"n-glyco-sequon-loss",
"o-glyco-site-loss"
],
"start_pos": 223,
"end_pos": 223,
"sequence_org": "T",
"sequence_mut": "R",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NQT->NQR).",
"chr_id": "13",
"chr_pos": "113144016",
"ref_nt": "G",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "T223",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs1415612218",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1415612218"
},
{
"id": "rs1415612218",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs1415612218"
}
],
"glycoeffect": [
"n-glyco-sequon-loss"
],
"start_pos": 231,
"end_pos": 231,
"sequence_org": "N",
"sequence_mut": "K",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NLT->KLT).",
"chr_id": "13",
"chr_pos": "113144041",
"ref_nt": "A",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "N231",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "P00742",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P00742"
}
],
"glycoeffect": [],
"start_pos": 339,
"end_pos": 339,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "A",
"sequence_mut": "V",
"comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (6).",
"chr_id": "13",
"chr_pos": "113149066",
"ref_nt": "C",
"alt_nt": "T",
"minor_allelic_frequency": "",
"site_lbl": "A339",
"disease": [
{
"disease_id": "DOID:4362",
"recommended_name": {
"id": "DOID:4362",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4362",
"name": "cervical cancer",
"description": "A female reproductive organ cancer that is located_in the cervix."
},
"synonyms": [
{
"id": "DOID:4362",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4362",
"name": "cervical neoplasm",
"description": ""
},
{
"id": "DOID:4362",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4362",
"name": "cervix cancer",
"description": ""
},
{
"id": "DOID:4362",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4362",
"name": "cervix uteri cancer",
"description": ""
},
{
"id": "DOID:4362",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4362",
"name": "neoplasm of uterine cervix",
"description": ""
},
{
"id": "DOID:4362",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4362",
"name": "tumor of the Cervix Uteri",
"description": ""
},
{
"id": "DOID:4362",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4362",
"name": "uterine cervical neoplasm",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "cervical cancer",
"description": "A primary or metastatic malignant neoplasm involving the cervix."
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "cervical neoplasm",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "tumor of the cervix uteri",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "tumour of the cervix uteri",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "uterine cervical neoplasm",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "cancer of uterine cervix",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "cervical cancer, somatic",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "cervix cancer",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "cervix uteri cancer",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant cervical neoplasm",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant cervical tumor",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant cervical tumour",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant cervix neoplasm",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant cervix tumor",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant cervix tumour",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant cervix uteri neoplasm",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant cervix uteri tumor",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant cervix uteri tumour",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant neoplasm of cervix",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant neoplasm of cervix uteri",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant neoplasm of the cervix",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant neoplasm of the cervix uteri",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant neoplasm of the uterine cervix",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant neoplasm of uterine cervix",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant tumor of cervix",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant tumor of cervix uteri",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant tumor of the cervix",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant tumor of the cervix uteri",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant tumor of the uterine cervix",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant tumor of uterine cervix",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant tumour of cervix",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant tumour of cervix uteri",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant tumour of the cervix",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant tumour of the cervix uteri",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant tumour of the uterine cervix",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant tumour of uterine cervix",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant uterine cervix neoplasm",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant uterine cervix tumor",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant uterine cervix tumour",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "uterine cervix cancer",
"description": ""
},
{
"id": "MIM:603956",
"resource": "MIM",
"url": "https://www.omim.org/entry/603956",
"name": "Cervical cancer",
"description": "Cervical cancer"
}
]
},
{
"disease_id": "DOID:11054",
"recommended_name": {
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "urinary bladder cancer",
"description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder."
},
"synonyms": [
{
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "bladder cancer",
"description": ""
},
{
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": "A primary or metastatic malignant neoplasm involving the bladder."
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "bladder cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "cancer of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumour",
"description": ""
},
{
"id": "MIM:109800",
"resource": "MIM",
"url": "https://www.omim.org/entry/109800",
"name": "Bladder cancer",
"description": "Bladder cancer"
}
]
},
{
"disease_id": "DOID:10534",
"recommended_name": {
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "stomach cancer",
"description": "A gastrointestinal system cancer that is located_in the stomach."
},
"synonyms": [
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric cancer",
"description": ""
},
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": "A primary or metastatic malignant neoplasm involving the stomach."
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca lesser curvature - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "cancer of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer risk after h. pylori infection",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumor",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumour",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant stomach neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "stomach cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca body - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "ca greater curvature of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, intestinal",
"description": ""
},
{
"id": "MIM:613659",
"resource": "MIM",
"url": "https://www.omim.org/entry/613659",
"name": "Gastric cancer",
"description": "Gastric cancer"
}
]
},
{
"disease_id": "DOID:1781",
"recommended_name": {
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid cancer",
"description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
},
"synonyms": [
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid gland cancer",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "Thyroid gland neoplasm",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant tumour of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid neoplasm",
"description": ""
}
]
},
{
"disease_id": "DOID:9256",
"recommended_name": {
"id": "DOID:9256",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:9256",
"name": "colorectal cancer",
"description": "A large intestine cancer that is located_in the colon and/or located_in the rectum."
},
"synonyms": [
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma."
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, advanced, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer with chromosomal instability, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectum cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectum neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "CRC",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "large intestine cancer",
"description": ""
},
{
"id": "MIM:114500",
"resource": "MIM",
"url": "https://www.omim.org/entry/114500",
"name": "Colorectal cancer",
"description": "Colorectal cancer"
}
]
},
{
"disease_id": "DOID:1319",
"recommended_name": {
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "brain cancer",
"description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain."
},
"synonyms": [
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "BT - Brain tumour",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "adult brain tumor",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "adult malignant brain neoplasm",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "brain neoplasm",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "brain neoplasm, adult",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "malignant brain tumour",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "malignant primary brain neoplasm",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "malignant primary brain tumor",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "malignant tumor of Brain",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "malignant tumor of adult brain",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "neoplasm of brain",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "primary brain neoplasm",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "primary brain tumor",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "primary malignant neoplasm of brain",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "tumor of the Brain",
"description": ""
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease"
]
},
{
"evidence": [
{
"id": "P00742",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P00742"
}
],
"glycoeffect": [
"o-glyco-site-loss"
],
"start_pos": 358,
"end_pos": 358,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "T",
"sequence_mut": "M",
"comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).",
"chr_id": "13",
"chr_pos": "113149123",
"ref_nt": "C",
"alt_nt": "T",
"minor_allelic_frequency": "",
"site_lbl": "T358",
"disease": [
{
"disease_id": "DOID:1324",
"recommended_name": {
"id": "DOID:1324",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1324",
"name": "lung cancer",
"description": "A respiratory system cancer that is located_in the lung."
},
"synonyms": [
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "LNCR1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "LNCR3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "adenocarcinoma of lung, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "LNCR4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "LNCR5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": "A malignant neoplasm involving the lung."
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "cancer of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung neoplasm",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumor",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumour",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung neoplasm",
"description": ""
},
{
"id": "MIM:211980",
"resource": "MIM",
"url": "https://www.omim.org/entry/211980",
"name": "Lung cancer",
"description": "Lung cancer"
}
]
},
{
"disease_id": "DOID:10283",
"recommended_name": {
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer",
"description": "A male reproductive organ cancer that is located_in the prostate."
},
"synonyms": [
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "NGP - new growth of prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "malignant tumor of the prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "tumor of the prostate",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, type 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "HPC9",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "EHBP1 familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "familial prostate cancer caused by mutation in EHBP1",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, type 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "HPC12",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, type 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "HPC5",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, type 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, susceptibility to, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "HPC3",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, type 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, susceptibility to, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "HPC4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, on chromosome 7",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "MSMB familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "familial prostate cancer caused by mutation in MSMB",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, type 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "HPC13",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, type 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "HPC8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "predisposing for prostate cancer",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, type 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "HPC6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "HPC10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate carcinoma",
"description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate carcinoma",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, somatic",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, hereditary",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "HPC7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer aggressiveness",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "RNASEL familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "familial prostate cancer caused by mutation in RNASEL",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, type 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "HPC1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "Prca1",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "HPC11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "HPC14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "HPC15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "HPCX1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer susceptibility, X-linked",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "HPCX2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MIM:611868",
"resource": "MIM",
"url": "https://www.omim.org/entry/611868",
"name": "Prostate cancer, hereditary, 12",
"description": "Prostate cancer, hereditary, 12"
},
{
"id": "MIM:611928",
"resource": "MIM",
"url": "https://www.omim.org/entry/611928",
"name": "Prostate cancer, hereditary, 13",
"description": "Prostate cancer, hereditary, 13"
},
{
"id": "MIM:176807",
"resource": "MIM",
"url": "https://www.omim.org/entry/176807",
"name": "Prostate cancer",
"description": "Prostate cancer"
},
{
"id": "MIM:601518",
"resource": "MIM",
"url": "https://www.omim.org/entry/601518",
"name": "Prostate cancer, hereditary, 1",
"description": "Prostate cancer, hereditary, 1"
},
{
"id": "MIM:611955",
"resource": "MIM",
"url": "https://www.omim.org/entry/611955",
"name": "Prostate cancer, hereditary, 11",
"description": "Prostate cancer, hereditary, 11"
}
]
},
{
"disease_id": "DOID:11054",
"recommended_name": {
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "urinary bladder cancer",
"description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder."
},
"synonyms": [
{
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "bladder cancer",
"description": ""
},
{
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": "A primary or metastatic malignant neoplasm involving the bladder."
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "bladder cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "cancer of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumour",
"description": ""
},
{
"id": "MIM:109800",
"resource": "MIM",
"url": "https://www.omim.org/entry/109800",
"name": "Bladder cancer",
"description": "Bladder cancer"
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease"
]
},
{
"evidence": [
{
"id": "P00742",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P00742"
},
{
"id": "rs1175120160",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1175120160"
},
{
"id": "rs1175120160",
"database": "NCI-TCGA",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1175120160"
},
{
"id": "rs1175120160",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs1175120160"
}
],
"glycoeffect": [
"n-glyco-sequon-gain",
"o-glyco-site-loss"
],
"start_pos": 428,
"end_pos": 428,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "K",
"sequence_mut": "N",
"comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (KDT->NDT).",
"chr_id": "13",
"chr_pos": "113149334",
"ref_nt": "G",
"alt_nt": "T",
"minor_allelic_frequency": "",
"site_lbl": "K428",
"disease": [
{
"disease_id": "DOID:1793",
"recommended_name": {
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "pancreatic cancer",
"description": "An endocrine gland cancer located_in the pancreas."
},
"synonyms": [
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "Ca body of pancreas",
"description": ""
},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "Ca head of pancreas",
"description": ""
},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "Ca tail of pancreas",
"description": ""
},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "malignant neoplasm of body of pancreas",
"description": ""
},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "malignant neoplasm of head of pancreas",
"description": ""
},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "malignant neoplasm of tail of pancreas",
"description": ""
},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "pancreas neoplasm",
"description": ""
},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "pancreatic neoplasm",
"description": ""
},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "pancreatic tumor",
"description": ""
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease",
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs1476602298",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1476602298"
},
{
"id": "rs1476602298",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs1476602298#frequency_tab"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 463,
"end_pos": 463,
"sequence_org": "D",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DRS->NRS).",
"chr_id": "13",
"chr_pos": "113149437",
"ref_nt": "A",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "D463",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs768448757",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs768448757"
},
{
"id": "rs768448757",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs768448757"
},
{
"id": "rs768448757",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs768448757"
}
],
"glycoeffect": [
"o-glyco-site-loss"
],
"start_pos": 476,
"end_pos": 476,
"sequence_org": "S",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->N).",
"chr_id": "13",
"chr_pos": "113149477",
"ref_nt": "A",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "S476",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs776514175",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs776514175"
},
{
"id": "rs776514175",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs776514175"
},
{
"id": "rs776514175",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs776514175"
}
],
"glycoeffect": [
"o-glyco-site-loss"
],
"start_pos": 476,
"end_pos": 476,
"sequence_org": "S",
"sequence_mut": "R",
"comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->R).",
"chr_id": "13",
"chr_pos": "113149478",
"ref_nt": "G",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "S476",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs1448368580",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1448368580"
},
{
"id": "rs1448368580",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs1448368580#frequency_tab"
}
],
"glycoeffect": [
"o-glyco-site-loss"
],
"start_pos": 483,
"end_pos": 483,
"sequence_org": "T",
"sequence_mut": "M",
"comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->M).",
"chr_id": "13",
"chr_pos": "113149498",
"ref_nt": "T",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "T483",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "P00742",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P00742"
},
{
"id": "rs759801225",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs759801225"
},
{
"id": "rs759801225",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs759801225"
},
{
"id": "rs759801225",
"database": "NCI-TCGA",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs759801225"
},
{
"id": "rs759801225",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs759801225"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 75,
"end_pos": 75,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "D",
"sequence_mut": "N",
"comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (DKT->NKT).",
"chr_id": "13",
"chr_pos": "113129604",
"ref_nt": "G",
"alt_nt": "A",
"minor_allelic_frequency": "",
"site_lbl": "D75",
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease",
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "P00742",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P00742"
}
],
"glycoeffect": [],
"start_pos": 80,
"end_pos": 80,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "F",
"sequence_mut": "L",
"comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).",
"chr_id": "13",
"chr_pos": "113138465",
"ref_nt": "C",
"alt_nt": "A",
"minor_allelic_frequency": "",
"site_lbl": "F80",
"disease": [
{
"disease_id": "DOID:1612",
"recommended_name": {
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast cancer",
"description": "A thoracic cancer that originates in the mammary gland."
},
"synonyms": [
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant neoplasm of breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant tumor of the breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary cancer",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "primary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, lobular, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of the breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial Male",
"description": ""
},
{
"id": "MIM:114480",
"resource": "MIM",
"url": "https://www.omim.org/entry/114480",
"name": "Breast cancer",
"description": "Breast cancer"
}
]
},
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
},
{
"disease_id": "DOID:9256",
"recommended_name": {
"id": "DOID:9256",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:9256",
"name": "colorectal cancer",
"description": "A large intestine cancer that is located_in the colon and/or located_in the rectum."
},
"synonyms": [
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma."
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, advanced, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer with chromosomal instability, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectum cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectum neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "CRC",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "large intestine cancer",
"description": ""
},
{
"id": "MIM:114500",
"resource": "MIM",
"url": "https://www.omim.org/entry/114500",
"name": "Colorectal cancer",
"description": "Colorectal cancer"
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease"
]
}
],
"mutagenesis": [],
"expression_tissue": [
{
"tissue": {
"name": "Adult mammalian kidney",
"namespace": "UBERON",
"id": "0000082",
"url": "http://purl.obolibrary.org/obo/UBERON_0000082"
},
"score": "67.49",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000126218",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000126218"
}
]
},
{
"tissue": {
"name": "Oral cavity",
"namespace": "UBERON",
"id": "0000167",
"url": "http://purl.obolibrary.org/obo/UBERON_0000167"
},
"score": "64.84",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000126218",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000126218"
}
]
},
{
"tissue": {
"name": "Stomach",
"namespace": "UBERON",
"id": "0000945",
"url": "http://purl.obolibrary.org/obo/UBERON_0000945"
},
"score": "72.08",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000126218",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000126218"
}
]
},
{
"tissue": {
"name": "Uterus",
"namespace": "UBERON",
"id": "0000995",
"url": "http://purl.obolibrary.org/obo/UBERON_0000995"
},
"score": "55.62",
"present": "LOW",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000126218",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000126218"
}
]
},
{
"tissue": {
"name": "Esophagus",
"namespace": "UBERON",
"id": "0001043",
"url": "http://purl.obolibrary.org/obo/UBERON_0001043"
},
"score": "94.3",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000126218",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000126218"
}
]
},
{
"tissue": {
"name": "Rectum",
"namespace": "UBERON",
"id": "0001052",
"url": "http://purl.obolibrary.org/obo/UBERON_0001052"
},
"score": "73.85",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000126218",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000126218"
}
]
},
{
"tissue": {
"name": "Colon",
"namespace": "UBERON",
"id": "0001155",
"url": "http://purl.obolibrary.org/obo/UBERON_0001155"
},
"score": "60.91",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000126218",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000126218"
}
]
},
{
"tissue": {
"name": "Urinary bladder",
"namespace": "UBERON",
"id": "0001255",
"url": "http://purl.obolibrary.org/obo/UBERON_0001255"
},
"score": "76",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000126218",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000126218"
}
]
},
{
"tissue": {
"name": "Thyroid gland",
"namespace": "UBERON",
"id": "0002046",
"url": "http://purl.obolibrary.org/obo/UBERON_0002046"
},
"score": "75.68",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000126218",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000126218"
}
]
},
{
"tissue": {
"name": "Lung",
"namespace": "UBERON",
"id": "0002048",
"url": "http://purl.obolibrary.org/obo/UBERON_0002048"
},
"score": "58.62",
"present": "LOW",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000126218",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000126218"
}
]
},
{
"tissue": {
"name": "Liver",
"namespace": "UBERON",
"id": "0002107",
"url": "http://purl.obolibrary.org/obo/UBERON_0002107"
},
"score": "91.58",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000126218",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000126218"
}
]
},
{
"tissue": {
"name": "Prostate gland",
"namespace": "UBERON",
"id": "0002367",
"url": "http://purl.obolibrary.org/obo/UBERON_0002367"
},
"score": "79.08",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000126218",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000126218"
}
]
},
{
"tissue": {
"name": "Thoracic mammary gland",
"namespace": "UBERON",
"id": "0005200",
"url": "http://purl.obolibrary.org/obo/UBERON_0005200"
},
"score": "76.36",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000126218",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000126218"
}
]
}
],
"expression_disease": [
{
"significant": "Yes",
"trend": "down",
"name": "Prostate cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10283",
"evidence": [
{
"database": "BioXpress",
"id": "P00742",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00742"
}
],
"disease": [
{
"disease_id": "DOID:10283",
"recommended_name": {
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer",
"description": "A male reproductive organ cancer that is located_in the prostate."
},
"synonyms": [
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "NGP - new growth of prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "malignant tumor of the prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "tumor of the prostate",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, type 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "HPC9",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "EHBP1 familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "familial prostate cancer caused by mutation in EHBP1",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, type 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "HPC12",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, type 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "HPC5",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, type 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, susceptibility to, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "HPC3",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, type 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, susceptibility to, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "HPC4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, on chromosome 7",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "MSMB familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "familial prostate cancer caused by mutation in MSMB",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, type 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "HPC13",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, type 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "HPC8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "predisposing for prostate cancer",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, type 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "HPC6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "HPC10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate carcinoma",
"description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate carcinoma",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, somatic",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, hereditary",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "HPC7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer aggressiveness",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "RNASEL familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "familial prostate cancer caused by mutation in RNASEL",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, type 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "HPC1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "Prca1",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "HPC11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "HPC14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "HPC15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "HPCX1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer susceptibility, X-linked",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "HPCX2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MIM:611868",
"resource": "MIM",
"url": "https://www.omim.org/entry/611868",
"name": "Prostate cancer, hereditary, 12",
"description": "Prostate cancer, hereditary, 12"
},
{
"id": "MIM:611928",
"resource": "MIM",
"url": "https://www.omim.org/entry/611928",
"name": "Prostate cancer, hereditary, 13",
"description": "Prostate cancer, hereditary, 13"
},
{
"id": "MIM:176807",
"resource": "MIM",
"url": "https://www.omim.org/entry/176807",
"name": "Prostate cancer",
"description": "Prostate cancer"
},
{
"id": "MIM:601518",
"resource": "MIM",
"url": "https://www.omim.org/entry/601518",
"name": "Prostate cancer, hereditary, 1",
"description": "Prostate cancer, hereditary, 1"
},
{
"id": "MIM:611955",
"resource": "MIM",
"url": "https://www.omim.org/entry/611955",
"name": "Prostate cancer, hereditary, 11",
"description": "Prostate cancer, hereditary, 11"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Stomach cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10534",
"evidence": [
{
"database": "BioXpress",
"id": "P00742",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00742"
}
],
"disease": [
{
"disease_id": "DOID:10534",
"recommended_name": {
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "stomach cancer",
"description": "A gastrointestinal system cancer that is located_in the stomach."
},
"synonyms": [
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric cancer",
"description": ""
},
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": "A primary or metastatic malignant neoplasm involving the stomach."
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca lesser curvature - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "cancer of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer risk after h. pylori infection",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumor",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumour",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant stomach neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "stomach cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca body - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "ca greater curvature of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, intestinal",
"description": ""
},
{
"id": "MIM:613659",
"resource": "MIM",
"url": "https://www.omim.org/entry/613659",
"name": "Gastric cancer",
"description": "Gastric cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Urinary bladder cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11054",
"evidence": [
{
"database": "BioXpress",
"id": "P00742",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00742"
}
],
"disease": [
{
"disease_id": "DOID:11054",
"recommended_name": {
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "urinary bladder cancer",
"description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder."
},
"synonyms": [
{
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "bladder cancer",
"description": ""
},
{
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": "A primary or metastatic malignant neoplasm involving the bladder."
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "bladder cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "cancer of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumour",
"description": ""
},
{
"id": "MIM:109800",
"resource": "MIM",
"url": "https://www.omim.org/entry/109800",
"name": "Bladder cancer",
"description": "Bladder cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Head and neck cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11934",
"evidence": [
{
"database": "BioXpress",
"id": "P00742",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00742"
}
],
"disease": [
{
"disease_id": "DOID:11934",
"recommended_name": {
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck cancer",
"description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
},
"synonyms": [
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck tumours",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head/neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "tumor of head and neck",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Lung cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1324",
"evidence": [
{
"database": "BioXpress",
"id": "P00742",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00742"
}
],
"disease": [
{
"disease_id": "DOID:1324",
"recommended_name": {
"id": "DOID:1324",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1324",
"name": "lung cancer",
"description": "A respiratory system cancer that is located_in the lung."
},
"synonyms": [
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "LNCR1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "LNCR3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "adenocarcinoma of lung, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "LNCR4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "LNCR5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": "A malignant neoplasm involving the lung."
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "cancer of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung neoplasm",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumor",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumour",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung neoplasm",
"description": ""
},
{
"id": "MIM:211980",
"resource": "MIM",
"url": "https://www.omim.org/entry/211980",
"name": "Lung cancer",
"description": "Lung cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Breast cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1612",
"evidence": [
{
"database": "BioXpress",
"id": "P00742",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00742"
}
],
"disease": [
{
"disease_id": "DOID:1612",
"recommended_name": {
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast cancer",
"description": "A thoracic cancer that originates in the mammary gland."
},
"synonyms": [
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant neoplasm of breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant tumor of the breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary cancer",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "primary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, lobular, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of the breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial Male",
"description": ""
},
{
"id": "MIM:114480",
"resource": "MIM",
"url": "https://www.omim.org/entry/114480",
"name": "Breast cancer",
"description": "Breast cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Thyroid cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1781",
"evidence": [
{
"database": "BioXpress",
"id": "P00742",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00742"
}
],
"disease": [
{
"disease_id": "DOID:1781",
"recommended_name": {
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid cancer",
"description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
},
"synonyms": [
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid gland cancer",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "Thyroid gland neoplasm",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant tumour of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Kidney cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:263",
"evidence": [
{
"database": "BioXpress",
"id": "P00742",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00742"
}
],
"disease": [
{
"disease_id": "DOID:263",
"recommended_name": {
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "kidney cancer",
"description": "A urinary system cancer that is located_in the kidney."
},
"synonyms": [
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant neoplasm of kidney except pelvis",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant tumour of kidney",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "renal cancer",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Liver cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:3571",
"evidence": [
{
"database": "BioXpress",
"id": "P00742",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00742"
}
],
"disease": [
{
"disease_id": "DOID:3571",
"recommended_name": {
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "liver cancer",
"description": "A hepatobiliary system cancer that is located_in the liver."
},
"synonyms": [
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Ca liver - primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Resectable malignant neoplasm of Liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant hepato-biliary neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant tumor of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "non-resectable primary hepatic malignant neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary liver cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "resectable malignant neoplasm of the liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, not specified as primary or secondary",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Uterine cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:363",
"evidence": [
{
"database": "BioXpress",
"id": "P00742",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00742"
}
],
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Esophageal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:5041",
"evidence": [
{
"database": "BioXpress",
"id": "P00742",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00742"
}
],
"disease": [
{
"disease_id": "DOID:5041",
"recommended_name": {
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophageal cancer",
"description": "A gastrointestinal system cancer that is located_in the esophagus."
},
"synonyms": [
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophagus cancer",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Distal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Proximal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of the middle Third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": "A primary or metastatic malignant neoplasm involving the esophagus."
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "oesophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of lower third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of middle third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of proximal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of upper third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of distal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of proximal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of the middle third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of abdominal oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of distal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of proximal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of the middle third of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Aerodigestive tract cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Escc, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "gastric cardia adenocarcinoma, susceptibility to",
"description": ""
},
{
"id": "MIM:133239",
"resource": "MIM",
"url": "https://www.omim.org/entry/133239",
"name": "Esophageal cancer",
"description": "Esophageal cancer"
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Colorectal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:9256",
"evidence": [
{
"database": "BioXpress",
"id": "P00742",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00742"
}
],
"disease": [
{
"disease_id": "DOID:9256",
"recommended_name": {
"id": "DOID:9256",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:9256",
"name": "colorectal cancer",
"description": "A large intestine cancer that is located_in the colon and/or located_in the rectum."
},
"synonyms": [
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma."
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, advanced, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer with chromosomal instability, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectum cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectum neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "CRC",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "large intestine cancer",
"description": ""
},
{
"id": "MIM:114500",
"resource": "MIM",
"url": "https://www.omim.org/entry/114500",
"name": "Colorectal cancer",
"description": "Colorectal cancer"
}
]
}
]
}
],
"species": [
{
"name": "Homo sapiens",
"taxid": 9606,
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"common_name": "Human"
}
],
"gene": [
{
"name": "F10",
"url": "https://www.uniprot.org/uniprot/P00742",
"locus": {
"chromosome": "13",
"start_pos": 113149529,
"end_pos": 113122799,
"strand": "-",
"evidence": [
{
"database": "Ensembl Gene",
"id": "ENSG00000126218",
"url": "https://www.ensembl.org/id/ENSG00000126218"
}
]
}
}
],
"crossref": [
{
"id": "ENSG00000126218",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000126218",
"database": "Bgee",
"categories": [
"Gene Expression"
]
},
{
"id": "P00742",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P00742",
"database": "BioMuta",
"categories": [
"Variation"
]
},
{
"id": "3.4.21.6",
"url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.21.6&UniProtAcc=P00742",
"database": "BRENDA",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "cd00054",
"url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054",
"database": "CDD",
"categories": [
"Protein Classification"
]
},
{
"id": "cd00190",
"url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00190",
"database": "CDD",
"categories": [
"Protein Classification"
]
},
{
"id": "CHEMBL244",
"url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL244",
"database": "ChEMBL",
"categories": [
"Other"
]
},
{
"id": "F10",
"url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=F10",
"database": "GeneCards",
"categories": [
"Gene Annotation",
"Organism-specific"
]
},
{
"id": "2159",
"url": "https://www.ncbi.nlm.nih.gov/gene/2159",
"database": "GeneID",
"categories": [
"Genome Annotation"
]
},
{
"id": "102",
"url": "https://glyconnect.expasy.org/browser/proteins/102",
"database": "GlyConnect",
"categories": [
"Glycoproteomics",
"Glycan"
]
},
{
"id": "3528",
"url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3528",
"database": "HGNC",
"categories": [
"Organism-specific"
]
},
{
"id": "P00742",
"url": "https://www.ebi.ac.uk/intact/interactors/id:P00742*",
"database": "IntAct",
"categories": [
"Other"
]
},
{
"id": "IPR000152",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR000152",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR000294",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR000294",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR000742",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR000742",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR001254",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR001254",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR001314",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR001314",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR001881",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR001881",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR009003",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR009003",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR012224",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR012224",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR017857",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR017857",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR018097",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR018097",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR018114",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR018114",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR033116",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR033116",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR035972",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR035972",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR043504",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR043504",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "hsa:2159",
"url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:2159",
"database": "KEGG Pathway",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "227600",
"url": "http://www.omim.org/entry/227600",
"database": "MIM",
"categories": [
"Other"
]
},
{
"id": "613872",
"url": "http://www.omim.org/entry/613872",
"database": "MIM",
"categories": [
"Other"
]
},
{
"id": "NX_P00742",
"url": "https://www.nextprot.org/entry/NX_P00742",
"database": "neXtProt",
"categories": [
"Protein",
"Organism-specific"
]
},
{
"id": "P00742",
"url": "https://www.oglcnac.mcw.edu/search/?query_protein=P00742",
"database": "O-GlcNAc Database",
"categories": [
"Glycoproteomics"
]
},
{
"id": "QKDWAEA",
"url": "https://omabrowser.org/oma/group/QKDWAEA/",
"database": "OMA",
"categories": [
"Protein Classification"
]
},
{
"id": "4629979at2759",
"url": "http://www.orthodb.org/?query=4629979at2759",
"database": "OrthoDB",
"categories": [
"Protein Classification"
]
},
{
"id": "PTHR24278",
"url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24278",
"database": "PANTHER",
"categories": [
"Protein Classification"
]
},
{
"id": "PTHR24278:SF28",
"url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24278:SF28",
"database": "PANTHER",
"categories": [
"Protein Classification"
]
},
{
"id": "1C5M",
"url": "https://www.rcsb.org/structure/1C5M",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1EZQ",
"url": "https://www.rcsb.org/structure/1EZQ",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1F0R",
"url": "https://www.rcsb.org/structure/1F0R",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1F0S",
"url": "https://www.rcsb.org/structure/1F0S",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1FAX",
"url": "https://www.rcsb.org/structure/1FAX",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1FJS",
"url": "https://www.rcsb.org/structure/1FJS",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1FXY",
"url": "https://www.rcsb.org/structure/1FXY",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1G2L",
"url": "https://www.rcsb.org/structure/1G2L",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1G2M",
"url": "https://www.rcsb.org/structure/1G2M",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1HCG",
"url": "https://www.rcsb.org/structure/1HCG",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1IOE",
"url": "https://www.rcsb.org/structure/1IOE",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1IQE",
"url": "https://www.rcsb.org/structure/1IQE",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1IQF",
"url": "https://www.rcsb.org/structure/1IQF",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1IQG",
"url": "https://www.rcsb.org/structure/1IQG",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1IQH",
"url": "https://www.rcsb.org/structure/1IQH",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1IQI",
"url": "https://www.rcsb.org/structure/1IQI",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1IQJ",
"url": "https://www.rcsb.org/structure/1IQJ",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1IQK",
"url": "https://www.rcsb.org/structure/1IQK",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1IQL",
"url": "https://www.rcsb.org/structure/1IQL",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1IQM",
"url": "https://www.rcsb.org/structure/1IQM",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1IQN",
"url": "https://www.rcsb.org/structure/1IQN",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1KSN",
"url": "https://www.rcsb.org/structure/1KSN",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1LPG",
"url": "https://www.rcsb.org/structure/1LPG",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1LPK",
"url": "https://www.rcsb.org/structure/1LPK",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1LPZ",
"url": "https://www.rcsb.org/structure/1LPZ",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1LQD",
"url": "https://www.rcsb.org/structure/1LQD",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1MQ5",
"url": "https://www.rcsb.org/structure/1MQ5",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1MQ6",
"url": "https://www.rcsb.org/structure/1MQ6",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1NFU",
"url": "https://www.rcsb.org/structure/1NFU",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1NFW",
"url": "https://www.rcsb.org/structure/1NFW",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1NFX",
"url": "https://www.rcsb.org/structure/1NFX",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1NFY",
"url": "https://www.rcsb.org/structure/1NFY",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1P0S",
"url": "https://www.rcsb.org/structure/1P0S",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1V3X",
"url": "https://www.rcsb.org/structure/1V3X",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1WU1",
"url": "https://www.rcsb.org/structure/1WU1",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1XKA",
"url": "https://www.rcsb.org/structure/1XKA",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1XKB",
"url": "https://www.rcsb.org/structure/1XKB",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1Z6E",
"url": "https://www.rcsb.org/structure/1Z6E",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2BMG",
"url": "https://www.rcsb.org/structure/2BMG",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2BOH",
"url": "https://www.rcsb.org/structure/2BOH",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2BOK",
"url": "https://www.rcsb.org/structure/2BOK",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2BQ6",
"url": "https://www.rcsb.org/structure/2BQ6",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2BQ7",
"url": "https://www.rcsb.org/structure/2BQ7",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2BQW",
"url": "https://www.rcsb.org/structure/2BQW",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2CJI",
"url": "https://www.rcsb.org/structure/2CJI",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2D1J",
"url": "https://www.rcsb.org/structure/2D1J",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2EI6",
"url": "https://www.rcsb.org/structure/2EI6",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2EI7",
"url": "https://www.rcsb.org/structure/2EI7",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2EI8",
"url": "https://www.rcsb.org/structure/2EI8",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2FZZ",
"url": "https://www.rcsb.org/structure/2FZZ",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2G00",
"url": "https://www.rcsb.org/structure/2G00",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2GD4",
"url": "https://www.rcsb.org/structure/2GD4",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2H9E",
"url": "https://www.rcsb.org/structure/2H9E",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2J2U",
"url": "https://www.rcsb.org/structure/2J2U",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2J34",
"url": "https://www.rcsb.org/structure/2J34",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2J38",
"url": "https://www.rcsb.org/structure/2J38",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2J4I",
"url": "https://www.rcsb.org/structure/2J4I",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2J94",
"url": "https://www.rcsb.org/structure/2J94",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2J95",
"url": "https://www.rcsb.org/structure/2J95",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2JKH",
"url": "https://www.rcsb.org/structure/2JKH",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2P16",
"url": "https://www.rcsb.org/structure/2P16",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2P3F",
"url": "https://www.rcsb.org/structure/2P3F",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2P3T",
"url": "https://www.rcsb.org/structure/2P3T",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2P3U",
"url": "https://www.rcsb.org/structure/2P3U",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2P93",
"url": "https://www.rcsb.org/structure/2P93",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2P94",
"url": "https://www.rcsb.org/structure/2P94",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2P95",
"url": "https://www.rcsb.org/structure/2P95",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2PHB",
"url": "https://www.rcsb.org/structure/2PHB",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2PR3",
"url": "https://www.rcsb.org/structure/2PR3",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2Q1J",
"url": "https://www.rcsb.org/structure/2Q1J",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2RA0",
"url": "https://www.rcsb.org/structure/2RA0",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2UWL",
"url": "https://www.rcsb.org/structure/2UWL",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2UWO",
"url": "https://www.rcsb.org/structure/2UWO",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2UWP",
"url": "https://www.rcsb.org/structure/2UWP",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2VH0",
"url": "https://www.rcsb.org/structure/2VH0",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2VH6",
"url": "https://www.rcsb.org/structure/2VH6",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2VVC",
"url": "https://www.rcsb.org/structure/2VVC",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2VVU",
"url": "https://www.rcsb.org/structure/2VVU",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2VVV",
"url": "https://www.rcsb.org/structure/2VVV",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2VWL",
"url": "https://www.rcsb.org/structure/2VWL",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2VWM",
"url": "https://www.rcsb.org/structure/2VWM",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2VWN",
"url": "https://www.rcsb.org/structure/2VWN",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2VWO",
"url": "https://www.rcsb.org/structure/2VWO",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2W26",
"url": "https://www.rcsb.org/structure/2W26",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2W3I",
"url": "https://www.rcsb.org/structure/2W3I",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2W3K",
"url": "https://www.rcsb.org/structure/2W3K",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2WYG",
"url": "https://www.rcsb.org/structure/2WYG",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2WYJ",
"url": "https://www.rcsb.org/structure/2WYJ",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2XBV",
"url": "https://www.rcsb.org/structure/2XBV",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2XBW",
"url": "https://www.rcsb.org/structure/2XBW",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2XBX",
"url": "https://www.rcsb.org/structure/2XBX",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2XBY",
"url": "https://www.rcsb.org/structure/2XBY",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2XC0",
"url": "https://www.rcsb.org/structure/2XC0",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2XC4",
"url": "https://www.rcsb.org/structure/2XC4",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2XC5",
"url": "https://www.rcsb.org/structure/2XC5",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2Y5F",
"url": "https://www.rcsb.org/structure/2Y5F",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2Y5G",
"url": "https://www.rcsb.org/structure/2Y5G",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2Y5H",
"url": "https://www.rcsb.org/structure/2Y5H",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2Y7X",
"url": "https://www.rcsb.org/structure/2Y7X",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2Y7Z",
"url": "https://www.rcsb.org/structure/2Y7Z",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2Y80",
"url": "https://www.rcsb.org/structure/2Y80",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2Y81",
"url": "https://www.rcsb.org/structure/2Y81",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2Y82",
"url": "https://www.rcsb.org/structure/2Y82",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3CEN",
"url": "https://www.rcsb.org/structure/3CEN",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3CS7",
"url": "https://www.rcsb.org/structure/3CS7",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3ENS",
"url": "https://www.rcsb.org/structure/3ENS",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3FFG",
"url": "https://www.rcsb.org/structure/3FFG",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3HPT",
"url": "https://www.rcsb.org/structure/3HPT",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3IIT",
"url": "https://www.rcsb.org/structure/3IIT",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3K9X",
"url": "https://www.rcsb.org/structure/3K9X",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3KL6",
"url": "https://www.rcsb.org/structure/3KL6",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3KQB",
"url": "https://www.rcsb.org/structure/3KQB",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3KQC",
"url": "https://www.rcsb.org/structure/3KQC",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3KQD",
"url": "https://www.rcsb.org/structure/3KQD",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3KQE",
"url": "https://www.rcsb.org/structure/3KQE",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3LIW",
"url": "https://www.rcsb.org/structure/3LIW",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3M36",
"url": "https://www.rcsb.org/structure/3M36",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3M37",
"url": "https://www.rcsb.org/structure/3M37",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3Q3K",
"url": "https://www.rcsb.org/structure/3Q3K",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3SW2",
"url": "https://www.rcsb.org/structure/3SW2",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3TK5",
"url": "https://www.rcsb.org/structure/3TK5",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3TK6",
"url": "https://www.rcsb.org/structure/3TK6",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "4A7I",
"url": "https://www.rcsb.org/structure/4A7I",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "4BTI",
"url": "https://www.rcsb.org/structure/4BTI",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "4BTT",
"url": "https://www.rcsb.org/structure/4BTT",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "4BTU",
"url": "https://www.rcsb.org/structure/4BTU",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "4Y6D",
"url": "https://www.rcsb.org/structure/4Y6D",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "4Y71",
"url": "https://www.rcsb.org/structure/4Y71",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "4Y76",
"url": "https://www.rcsb.org/structure/4Y76",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "4Y79",
"url": "https://www.rcsb.org/structure/4Y79",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "4Y7A",
"url": "https://www.rcsb.org/structure/4Y7A",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "4Y7B",
"url": "https://www.rcsb.org/structure/4Y7B",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "4ZH8",
"url": "https://www.rcsb.org/structure/4ZH8",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "4ZHA",
"url": "https://www.rcsb.org/structure/4ZHA",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "5JQY",
"url": "https://www.rcsb.org/structure/5JQY",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "5JTC",
"url": "https://www.rcsb.org/structure/5JTC",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "5JZ8",
"url": "https://www.rcsb.org/structure/5JZ8",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "5JZU",
"url": "https://www.rcsb.org/structure/5JZU",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "5K0H",
"url": "https://www.rcsb.org/structure/5K0H",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "5VOE",
"url": "https://www.rcsb.org/structure/5VOE",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "5VOF",
"url": "https://www.rcsb.org/structure/5VOF",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "6Q9F",
"url": "https://www.rcsb.org/structure/6Q9F",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "6Q9I",
"url": "https://www.rcsb.org/structure/6Q9I",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "6RK9",
"url": "https://www.rcsb.org/structure/6RK9",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "6YYW",
"url": "https://www.rcsb.org/structure/6YYW",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "6YYX",
"url": "https://www.rcsb.org/structure/6YYX",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "6YYY",
"url": "https://www.rcsb.org/structure/6YYY",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "6Z6Q",
"url": "https://www.rcsb.org/structure/6Z6Q",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "6Z6R",
"url": "https://www.rcsb.org/structure/6Z6R",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "7AHU",
"url": "https://www.rcsb.org/structure/7AHU",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "7BMI",
"url": "https://www.rcsb.org/structure/7BMI",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "7BMJ",
"url": "https://www.rcsb.org/structure/7BMJ",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "7E6J",
"url": "https://www.rcsb.org/structure/7E6J",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "7TPP",
"url": "https://www.rcsb.org/structure/7TPP",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "7TPQ",
"url": "https://www.rcsb.org/structure/7TPQ",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "7YB9",
"url": "https://www.rcsb.org/structure/7YB9",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "7YBB",
"url": "https://www.rcsb.org/structure/7YBB",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "7YBC",
"url": "https://www.rcsb.org/structure/7YBC",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "8EOK",
"url": "https://www.rcsb.org/structure/8EOK",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "PF00008",
"url": "http://pfam.xfam.org/family/PF00008",
"database": "Pfam",
"categories": [
"Protein Classification"
]
},
{
"id": "PF00089",
"url": "http://pfam.xfam.org/family/PF00089",
"database": "Pfam",
"categories": [
"Protein Classification"
]
},
{
"id": "PF00594",
"url": "http://pfam.xfam.org/family/PF00594",
"database": "Pfam",
"categories": [
"Protein Classification"
]
},
{
"id": "PF14670",
"url": "http://pfam.xfam.org/family/PF14670",
"database": "Pfam",
"categories": [
"Protein Classification"
]
},
{
"id": "P00742",
"url": "https://pharos.nih.gov/targets/P00742",
"database": "PHAROS",
"categories": [
"Organism-specific"
]
},
{
"id": "PR:000051163",
"url": "https://proconsortium.org/app/entry/PR:000051163",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051164",
"url": "https://proconsortium.org/app/entry/PR:000051164",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051165",
"url": "https://proconsortium.org/app/entry/PR:000051165",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051166",
"url": "https://proconsortium.org/app/entry/PR:000051166",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051167",
"url": "https://proconsortium.org/app/entry/PR:000051167",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051168",
"url": "https://proconsortium.org/app/entry/PR:000051168",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051169",
"url": "https://proconsortium.org/app/entry/PR:000051169",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051170",
"url": "https://proconsortium.org/app/entry/PR:000051170",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051171",
"url": "https://proconsortium.org/app/entry/PR:000051171",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051172",
"url": "https://proconsortium.org/app/entry/PR:000051172",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051173",
"url": "https://proconsortium.org/app/entry/PR:000051173",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051174",
"url": "https://proconsortium.org/app/entry/PR:000051174",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051175",
"url": "https://proconsortium.org/app/entry/PR:000051175",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051176",
"url": "https://proconsortium.org/app/entry/PR:000051176",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051177",
"url": "https://proconsortium.org/app/entry/PR:000051177",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051178",
"url": "https://proconsortium.org/app/entry/PR:000051178",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051179",
"url": "https://proconsortium.org/app/entry/PR:000051179",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051180",
"url": "https://proconsortium.org/app/entry/PR:000051180",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051181",
"url": "https://proconsortium.org/app/entry/PR:000051181",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051182",
"url": "https://proconsortium.org/app/entry/PR:000051182",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051183",
"url": "https://proconsortium.org/app/entry/PR:000051183",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051184",
"url": "https://proconsortium.org/app/entry/PR:000051184",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051185",
"url": "https://proconsortium.org/app/entry/PR:000051185",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051186",
"url": "https://proconsortium.org/app/entry/PR:000051186",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051187",
"url": "https://proconsortium.org/app/entry/PR:000051187",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051188",
"url": "https://proconsortium.org/app/entry/PR:000051188",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051189",
"url": "https://proconsortium.org/app/entry/PR:000051189",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051190",
"url": "https://proconsortium.org/app/entry/PR:000051190",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051191",
"url": "https://proconsortium.org/app/entry/PR:000051191",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051192",
"url": "https://proconsortium.org/app/entry/PR:000051192",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051193",
"url": "https://proconsortium.org/app/entry/PR:000051193",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051194",
"url": "https://proconsortium.org/app/entry/PR:000051194",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051195",
"url": "https://proconsortium.org/app/entry/PR:000051195",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051196",
"url": "https://proconsortium.org/app/entry/PR:000051196",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051197",
"url": "https://proconsortium.org/app/entry/PR:000051197",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051198",
"url": "https://proconsortium.org/app/entry/PR:000051198",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051199",
"url": "https://proconsortium.org/app/entry/PR:000051199",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051200",
"url": "https://proconsortium.org/app/entry/PR:000051200",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051201",
"url": "https://proconsortium.org/app/entry/PR:000051201",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000051202",
"url": "https://proconsortium.org/app/entry/PR:000051202",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR_P00742",
"url": "http://purl.obolibrary.org/obo/PR_P00742",
"database": "PRO",
"categories": [
"Protein"
]
},
{
"id": "R-HSA-140834",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-140875",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-159740",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159740",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-159763",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159763",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-159782",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159782",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-9672383",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9672383",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-9672396",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9672396",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-9673202",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9673202",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "NP_000495",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000495",
"database": "RefSeq",
"categories": [
"Protein"
]
},
{
"id": "P00742",
"url": "DISABLED",
"database": "UniCarbKB",
"categories": [
"Glycoproteomics"
]
},
{
"id": "B7ZBK1",
"url": "https://www.uniprot.org/uniprot/B7ZBK1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "B7ZBK1-1",
"url": "https://www.uniprot.org/uniprot/B7ZBK1-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "F8WBM7",
"url": "https://www.uniprot.org/uniprot/F8WBM7",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "F8WBM7-1",
"url": "https://www.uniprot.org/uniprot/F8WBM7-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "P00742-1",
"url": "https://www.uniprot.org/uniprot/P00742-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "Q5JVE8",
"url": "https://www.uniprot.org/uniprot/Q5JVE8",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "Q5JVE8-1",
"url": "https://www.uniprot.org/uniprot/Q5JVE8-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
}
],
"sequence": {
"sequence": "MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK",
"length": 488,
"header": "sp|P00742-1|FA10_HUMAN Isoform 1 of Coagulation factor X OS=Homo sapiens OX=9606 GN=F10 PE=1 SV=2 CANONICAL=P00742-1"
},
"isoforms": [
{
"isoform_ac": "B7ZBK1-1",
"url": "",
"sequence": {
"sequence": "MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRGTGTRSRRRAVRRCTRWRWSSSTTGSQRRPMTSTSPCSGSRPPSPSA",
"length": 334,
"header": "tr|B7ZBK1-1|FA10_HUMAN Computationally mapped isoform of Coagulation factor X OS=Homo sapiens OX=9606 GN=F10 PE=1 SV=1 CANONICAL=P00742-1"
},
"locus": {
"chromosome": "13",
"start_pos": 113149056,
"end_pos": 113122856,
"strand": "-",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000409306.5",
"url": "https://www.ensembl.org/id/ENST00000409306.5"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000387092.1",
"url": "https://www.ensembl.org/id/ENSP00000387092.1"
}
]
}
},
{
"isoform_ac": "F8WBM7-1",
"url": "",
"sequence": {
"sequence": "MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELCMLIFAL",
"length": 130,
"header": "tr|F8WBM7-1|F8WBM7_HUMAN Computationally mapped isoform of Coagulation factor X OS=Homo sapiens OX=9606 GN=F10 PE=1 SV=1 CANONICAL=P00742-1"
},
"locus": {
"chromosome": "13",
"start_pos": 113140586,
"end_pos": 113122856,
"strand": "-",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000410083.6",
"url": "https://www.ensembl.org/id/ENST00000410083.6"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000386320.2",
"url": "https://www.ensembl.org/id/ENSP00000386320.2"
}
]
}
},
{
"isoform_ac": "P00742-1",
"url": "",
"sequence": {
"sequence": "MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK",
"length": 488,
"header": "sp|P00742-1|FA10_HUMAN Isoform 1 of Coagulation factor X OS=Homo sapiens OX=9606 GN=F10 PE=1 SV=2 CANONICAL=P00742-1"
},
"locus": {
"chromosome": "13",
"start_pos": 113149514,
"end_pos": 113122856,
"strand": "-",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000375559.8",
"url": "https://www.ensembl.org/id/ENST00000375559.8"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000364709.3",
"url": "https://www.ensembl.org/id/ENSP00000364709.3"
}
]
}
},
{
"isoform_ac": "Q5JVE8-1",
"url": "",
"sequence": {
"sequence": "MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKGTGTRSRRRAVRRCTRWRWSSSTTGSQRRPMTSTSPCSGSRPPSPSA",
"length": 332,
"header": "tr|Q5JVE8-1|FA10_HUMAN Computationally mapped isoform of Coagulation factor X OS=Homo sapiens OX=9606 GN=F10 PE=1 SV=1 CANONICAL=P00742-1"
},
"locus": {
"chromosome": "13",
"start_pos": 113149056,
"end_pos": 113122856,
"strand": "-",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000375551.7",
"url": "https://www.ensembl.org/id/ENST00000375551.7"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000364701.3",
"url": "https://www.ensembl.org/id/ENSP00000364701.3"
}
]
}
}
],
"glycosylation": [
{
"glytoucan_ac": "G43417UB",
"type": "O-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "T",
"relation": "attached",
"comment": "",
"start_pos": 188,
"start_aa": "Thr",
"end_pos": 188,
"end_aa": "Thr",
"residue": "Thr",
"site_lbl": "Thr188",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "22171320",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/22171320"
}
]
},
{
"glytoucan_ac": "G53434XO",
"type": "O-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "T",
"relation": "attached",
"comment": "",
"start_pos": 188,
"start_aa": "Thr",
"end_pos": 188,
"end_aa": "Thr",
"residue": "Thr",
"site_lbl": "Thr188",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "30459171",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/30459171"
}
]
},
{
"glytoucan_ac": "G43417UB",
"type": "O-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "S",
"relation": "attached",
"comment": "",
"start_pos": 189,
"start_aa": "Ser",
"end_pos": 189,
"end_aa": "Ser",
"residue": "Ser",
"site_lbl": "Ser189",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "22171320",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/22171320"
}
]
},
{
"glytoucan_ac": "G43417UB",
"type": "O-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "S",
"relation": "attached",
"comment": "",
"start_pos": 190,
"start_aa": "Ser",
"end_pos": 190,
"end_aa": "Ser",
"residue": "Ser",
"site_lbl": "Ser190",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "22171320",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/22171320"
}
]
},
{
"glytoucan_ac": "G43417UB",
"type": "O-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "S",
"relation": "attached",
"comment": "",
"start_pos": 197,
"start_aa": "Ser",
"end_pos": 197,
"end_aa": "Ser",
"residue": "Ser",
"site_lbl": "Ser197",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "22171320",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/22171320"
}
]
},
{
"glytoucan_ac": "G43417UB",
"type": "O-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "T",
"relation": "attached",
"comment": "",
"start_pos": 199,
"start_aa": "Thr",
"end_pos": 199,
"end_aa": "Thr",
"residue": "Thr",
"site_lbl": "Thr199",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "22171320",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/22171320"
}
]
},
{
"glytoucan_ac": "",
"type": "O-linked",
"subtype": "O-GalNAcylation",
"site_category": "reported",
"site_seq": "T",
"relation": "attached",
"comment": "O-linked (GalNAc...) threonine O-GalNAcylation",
"start_pos": 199,
"start_aa": "Thr",
"end_pos": 199,
"end_aa": "Thr",
"residue": "Thr",
"site_lbl": "Thr199",
"evidence": [
{
"id": "P00742",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00742#ptm_processing"
},
{
"id": "8243461",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/8243461"
}
]
},
{
"glytoucan_ac": "G43417UB",
"type": "O-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "Y",
"relation": "attached",
"comment": "",
"start_pos": 203,
"start_aa": "Tyr",
"end_pos": 203,
"end_aa": "Tyr",
"residue": "Tyr",
"site_lbl": "Tyr203",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "22171320",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/22171320"
}
]
},
{
"glytoucan_ac": "",
"type": "O-linked",
"subtype": "O-GalNAcylation",
"site_category": "reported",
"site_seq": "T",
"relation": "attached",
"comment": "O-linked (GalNAc...) threonine O-GalNAcylation",
"start_pos": 211,
"start_aa": "Thr",
"end_pos": 211,
"end_aa": "Thr",
"residue": "Thr",
"site_lbl": "Thr211",
"evidence": [
{
"id": "P00742",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00742#ptm_processing"
},
{
"id": "8243461",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/8243461"
},
{
"id": "23677006",
"database": "Automatic Literature Mining",
"url": "https://research.bioinformatics.udel.edu/glyco/pmid/23677006"
},
{
"id": "23677006",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/23677006"
}
]
},
{
"glytoucan_ac": "G06356OH",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
}
]
},
{
"glytoucan_ac": "G18938DW",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: T-199, T-211, N-221, N-231",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G20425TQ",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
}
]
},
{
"glytoucan_ac": "G23863VK",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
}
]
},
{
"glytoucan_ac": "G24501HF",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "ASN-221 and ASN-231 ; ASN-221 and ASN-231",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G29857RC",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: ASN-221 AND ASN-231 ; ASN-221 AND ASN-231",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G32854GF",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: ASN-221 AND ASN-231 ; ASN-221 AND ASN-231",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G36191CD",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: T-199, T-211, N-221, N-231",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G41882MT",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
}
]
},
{
"glytoucan_ac": "G45359RY",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "ASN-221 AND ASN-231",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G46568MX",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "ASN-221 AND ASN-231",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G47012YE",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
}
]
},
{
"glytoucan_ac": "G49478NM",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: ASN-221 AND ASN-231 ; ASN-221 AND ASN-231",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G50045TK",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
}
]
},
{
"glytoucan_ac": "G59536GA",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
}
]
},
{
"glytoucan_ac": "G68866GS",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: ASN-221 AND ASN-231 ; ASN-221 AND ASN-231",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G72797UR",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
}
]
},
{
"glytoucan_ac": "G73073LQ",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "ASN-221 and ASN-231 ; ASN-221 and ASN-231",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G75850OP",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: ASN-221 AND ASN-231 ; ASN-221 AND ASN-231",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G78059CC",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "ASN-221 and ASN-231 ; ASN-221 and ASN-231",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G79809MM",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: T-199, T-211, N-221, N-231",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G81263BG",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
}
]
},
{
"glytoucan_ac": "G84452RH",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
}
]
},
{
"glytoucan_ac": "G85678WN",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: ASN-221 AND ASN-231 ; ASN-221 AND ASN-231",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G88068QT",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "ASN-221 AND ASN-231",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G91365ZQ",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "ASN-221 and ASN-231 ; ASN-221 and ASN-231",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "",
"type": "N-linked",
"subtype": "",
"site_category": "reported",
"site_seq": "N",
"relation": "attached",
"comment": "N-linked (GlcNAc...) asparagine",
"start_pos": 221,
"start_aa": "Asn",
"end_pos": 221,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn221",
"evidence": [
{
"id": "P00742",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00742#ptm_processing"
},
{
"id": "8243461",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/8243461"
}
]
},
{
"glytoucan_ac": "G06356OH",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
}
]
},
{
"glytoucan_ac": "G18938DW",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: T-199, T-211, N-221, N-231",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G20425TQ",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
}
]
},
{
"glytoucan_ac": "G23863VK",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
}
]
},
{
"glytoucan_ac": "G24501HF",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
}
]
},
{
"glytoucan_ac": "G29857RC",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: T-199, T-211, N-221, N-231",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G32854GF",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
}
]
},
{
"glytoucan_ac": "G36191CD",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: T-199, T-211, N-221, N-231",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G41882MT",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
}
]
},
{
"glytoucan_ac": "G45359RY",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: T-199, T-211, N-221, N-231",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G46568MX",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: T-199, T-211, N-221, N-231",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G47012YE",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
}
]
},
{
"glytoucan_ac": "G49478NM",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: T-199, T-211, N-221, N-231",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G50045TK",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
}
]
},
{
"glytoucan_ac": "G59536GA",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
}
]
},
{
"glytoucan_ac": "G68866GS",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
}
]
},
{
"glytoucan_ac": "G72797UR",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
}
]
},
{
"glytoucan_ac": "G73073LQ",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: T-199, T-211, N-221, N-231",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G75850OP",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: T-199, T-211, N-221, N-231",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G78059CC",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: T-199, T-211, N-221, N-231",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G79809MM",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: T-199, T-211, N-221, N-231",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G81263BG",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
}
]
},
{
"glytoucan_ac": "G84452RH",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
}
]
},
{
"glytoucan_ac": "G85678WN",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: T-199, T-211, N-221, N-231",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G88068QT",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: T-199, T-211, N-221, N-231",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "G91365ZQ",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "GlycoSuiteDB curation notes. Reported structure can be attached to the following: T-199, T-211, N-221, N-231",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
},
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
]
},
{
"glytoucan_ac": "",
"type": "N-linked",
"subtype": "",
"site_category": "reported",
"site_seq": "N",
"relation": "attached",
"comment": "N-linked (GlcNAc...) asparagine",
"start_pos": 231,
"start_aa": "Asn",
"end_pos": 231,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn231",
"evidence": [
{
"id": "P00742",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00742#ptm_processing"
},
{
"id": "8243461",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/8243461"
}
]
},
{
"glytoucan_ac": "G43417UB",
"type": "O-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "S",
"relation": "attached",
"comment": "",
"start_pos": 476,
"start_aa": "Ser",
"end_pos": 476,
"end_aa": "Ser",
"residue": "Ser",
"site_lbl": "Ser476",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "22171320",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/22171320"
}
]
},
{
"glytoucan_ac": "G57321FI",
"type": "O-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "SHAPEVITSSPLK",
"relation": "attached",
"comment": "Data provided by GlycoDomainViewer",
"start_pos": 476,
"start_aa": "Ser",
"end_pos": 488,
"end_aa": "Lys",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "23584533",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/23584533"
},
{
"id": "10.1038/emboj.2013.79",
"database": "DOI",
"url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79"
}
]
},
{
"glytoucan_ac": "G43417UB",
"type": "O-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "T",
"relation": "attached",
"comment": "",
"start_pos": 483,
"start_aa": "Thr",
"end_pos": 483,
"end_aa": "Thr",
"residue": "Thr",
"site_lbl": "Thr483",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "22171320",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/22171320"
}
]
},
{
"glytoucan_ac": "G57321FI",
"type": "O-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "T",
"relation": "attached",
"comment": "Data provided by GlycoDomainViewer",
"start_pos": 483,
"start_aa": "Thr",
"end_pos": 483,
"end_aa": "Thr",
"residue": "Thr",
"site_lbl": "Thr483",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "23584533",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/23584533"
},
{
"id": "10.1038/emboj.2013.79",
"database": "DOI",
"url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79"
}
]
},
{
"glytoucan_ac": "G43417UB",
"type": "O-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "S",
"relation": "attached",
"comment": "",
"start_pos": 484,
"start_aa": "Ser",
"end_pos": 484,
"end_aa": "Ser",
"residue": "Ser",
"site_lbl": "Ser484",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "22171320",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/22171320"
}
]
},
{
"glytoucan_ac": "G43417UB",
"type": "O-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "S",
"relation": "attached",
"comment": "",
"start_pos": 485,
"start_aa": "Ser",
"end_pos": 485,
"end_aa": "Ser",
"residue": "Ser",
"site_lbl": "Ser485",
"evidence": [
{
"id": "P00742",
"database": "UniCarbKB",
"url": ""
},
{
"id": "22171320",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/22171320"
}
]
},
{
"glytoucan_ac": "G49108TO",
"type": "O-linked",
"subtype": "O-GlcNAcylation",
"site_category": "reported_with_glycan",
"site_seq": "",
"relation": "attached",
"comment": "O-GlcNAcylation",
"evidence": [
{
"id": "P00742",
"database": "O-GlcNAc Database",
"url": "https://www.oglcnac.mcw.edu/search/?query_protein=P00742"
},
{
"id": "34019948",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/34019948"
}
]
},
{
"glytoucan_ac": "G80111QD",
"type": "O-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "",
"relation": "attached",
"comment": "",
"evidence": [
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
}
]
},
{
"glytoucan_ac": "G81006GJ",
"type": "O-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "",
"relation": "attached",
"comment": "",
"evidence": [
{
"id": "102",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
},
{
"id": "7620335",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/7620335"
}
]
}
],
"phosphorylation": [],
"glycation": [],
"keywords": [
"enzyme",
"glycoprotein",
"glycoprotein_reported_with_glycan",
"glycoprotein_reported"
],
"publication": [
{
"title": "Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology",
"journal": "EMBO J",
"date": "2013",
"authors": "Steentoft C., Vakhrushev S.Y., Joshi H.J., Kong Y., Vester-Christensen M.B., Schjoldager K.T., Lavrsen K., Dabelsteen S., Pedersen N.B., Marcos-Silva L., Gupta R., Bennett E.P., Mandel U., Brunak S., Wandall H.H., Levery S.B., Clausen H.",
"evidence": [
{
"database": "UniCarbKB",
"id": "P00742",
"url": ""
}
],
"reference": [
{
"type": "DOI",
"id": "10.1038/emboj.2013.79",
"url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79"
}
]
},
{
"title": "Relocating the active site of activated protein C eliminates the need for its protein S cofactor. A fluorescence resonance energy transfer study.",
"journal": "The Journal of biological chemistry",
"date": "1999",
"authors": "Yegneswaran S, Smirnov MD, Safa O, Esmon NL, Esmon CT, Johnson AE",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140875",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875"
}
],
"reference": [
{
"type": "PubMed",
"id": "10026158",
"url": "https://glygen.org/publication/PubMed/10026158"
}
]
},
{
"title": "Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid.",
"journal": "Blood",
"date": "1999",
"authors": "Furie B, Bouchard BA, Furie BC",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-159740",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159740"
}
],
"reference": [
{
"type": "PubMed",
"id": "10068650",
"url": "https://glygen.org/publication/PubMed/10068650"
}
]
},
{
"title": "Characterization of single-nucleotide polymorphisms in coding regions of human genes.",
"journal": "Nat. Genet.",
"date": "1999",
"authors": "Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, Shaw N, Lane CR, Lim EP, Kalyanaraman N, Nemesh J, Ziaugra L, Friedland L, Rolfe A, Warrington J, Lipshutz R, Daley GQ, Lander ES",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "10391209",
"url": "https://glygen.org/publication/PubMed/10391209"
}
]
},
{
"title": "Substitution of Arg527 and Arg531 in factor VIII associated with mild haemophilia A: characterization in terms of subunit interaction and cofactor function.",
"journal": "British journal of haematology",
"date": "1999",
"authors": "Celie PH, Van Stempvoort G, Jorieux S, Mazurier C, Van Mourik JA, Mertens K",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9672396",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9672396"
}
],
"reference": [
{
"type": "PubMed",
"id": "10468875",
"url": "https://glygen.org/publication/PubMed/10468875"
}
]
},
{
"title": "A family with hereditary factor X deficiency with a point mutation Gla32 to Gln in the Gla domain (factor X Tokyo).",
"journal": "British journal of haematology",
"date": "1999",
"authors": "Zama T, Murata M, Watanabe R, Yokoyama K, Moriki T, Ambo H, Murakami H, Kikuchi M, Ikeda Y",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "10468877",
"url": "https://glygen.org/publication/PubMed/10468877"
}
]
},
{
"title": "Mechanisms for the involvement of high molecular weight kininogen in surface-dependent reactions of Hageman factor.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "1976",
"authors": "Griffin JH, Cochrane CG",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "1066663",
"url": "https://glygen.org/publication/PubMed/1066663"
}
]
},
{
"title": "The impact of Glu102Lys on the factor X function in a patient with a doubly homozygous factor X deficiency (Gla14Lys and Glu102Lys).",
"journal": "Thrombosis and haemostasis",
"date": "2000",
"authors": "Forberg E, Huhmann I, Jimenez-Boj E, Watzke HH",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "10739379",
"url": "https://glygen.org/publication/PubMed/10739379"
}
]
},
{
"title": "Molecular analysis of the genotype-phenotype relationship in factor X deficiency.",
"journal": "Human genetics",
"date": "2000",
"authors": "Millar DS, Elliston L, Deex P, Krawczak M, Wacey AI, Reynaud J, Nieuwenhuis HK, Bolton-Maggs P, Mannucci PM, Reverter JC, Cachia P, Pasi KJ, Layton DM, Cooper DN",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "10746568",
"url": "https://glygen.org/publication/PubMed/10746568"
}
]
},
{
"title": "Thrombin-mediated feedback activation of factor XI on the activated platelet surface is preferred over contact activation by factor XIIa or factor XIa.",
"journal": "The Journal of biological chemistry",
"date": "2000",
"authors": "Baglia FA, Walsh PN",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "10781579",
"url": "https://glygen.org/publication/PubMed/10781579"
}
]
},
{
"title": "The vitamin K-dependent carboxylase.",
"journal": "The Journal of nutrition",
"date": "2000",
"authors": "Berkner KL",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-159740",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159740"
}
],
"reference": [
{
"type": "PubMed",
"id": "10917896",
"url": "https://glygen.org/publication/PubMed/10917896"
}
]
},
{
"title": "The soluble endothelial protein C receptor binds to activated neutrophils: involvement of proteinase-3 and CD11b/CD18.",
"journal": "Journal of immunology (Baltimore, Md. : 1950)",
"date": "2000",
"authors": "Kurosawa S, Esmon CT, Stearns-Kurosawa DJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140875",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875"
}
],
"reference": [
{
"type": "PubMed",
"id": "11035113",
"url": "https://glygen.org/publication/PubMed/11035113"
}
]
},
{
"title": "Factor XII-dependent contact activation on endothelial cells and binding proteins gC1qR and cytokeratin 1.",
"journal": "Thrombosis and haemostasis",
"date": "2001",
"authors": "Joseph K, Shibayama Y, Ghebrehiwet B, Kaplan AP",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "11204562",
"url": "https://glygen.org/publication/PubMed/11204562"
}
]
},
{
"title": "Endothelial cell protein C receptor plays an important role in protein C activation in vivo.",
"journal": "Blood",
"date": "2001",
"authors": "Taylor FB Jr, Peer GT, Lockhart MS, Ferrell G, Esmon CT",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140875",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875"
}
],
"reference": [
{
"type": "PubMed",
"id": "11238108",
"url": "https://glygen.org/publication/PubMed/11238108"
}
]
},
{
"title": "A dysfunctional factor X (factor X San Giovanni Rotondo) present at homozygous and double heterozygous level: identification of a novel microdeletion (delC556) and missense mutation (Lys(408)-->Asn) in the factor X gene. A study of an Italian family.",
"journal": "Thrombosis research",
"date": "2001",
"authors": "Simioni P, Vianello F, Kalafatis M, Barzon L, Ladogana S, Paolucci P, Carotenuto M, Dal Bello F, Palu G, Girolami A",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "11248282",
"url": "https://glygen.org/publication/PubMed/11248282"
}
]
},
{
"title": "Three ways to make a vesicle.",
"journal": "Nature reviews. Molecular cell biology",
"date": "2000",
"authors": "Kirchhausen T",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-159763",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159763"
}
],
"reference": [
{
"type": "PubMed",
"id": "11252894",
"url": "https://glygen.org/publication/PubMed/11252894"
}
]
},
{
"title": "Model for a factor IX activation complex on blood platelets: dimeric conformation of factor XIa is essential.",
"journal": "Blood",
"date": "2001",
"authors": "Gailani D, Ho D, Sun MF, Cheng Q, Walsh PN",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "11342438",
"url": "https://glygen.org/publication/PubMed/11342438"
}
]
},
{
"title": "Tethered processivity of the vitamin K-dependent carboxylase: factor IX is efficiently modified in a mechanism which distinguishes Gla's from Glu's and which accounts for comprehensive carboxylation in vivo.",
"journal": "Biochemistry",
"date": "2001",
"authors": "Stenina O, Pudota BN, McNally BA, Hommema EL, Berkner KL",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-159740",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159740"
}
],
"reference": [
{
"type": "PubMed",
"id": "11513608",
"url": "https://glygen.org/publication/PubMed/11513608"
}
]
},
{
"title": "Factor XI binding to the platelet glycoprotein Ib-IX-V complex promotes factor XI activation by thrombin.",
"journal": "The Journal of biological chemistry",
"date": "2002",
"authors": "Baglia FA, Badellino KO, Li CQ, Lopez JA, Walsh PN",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "11696542",
"url": "https://glygen.org/publication/PubMed/11696542"
}
]
},
{
"title": "A new factor X defect (factor X Padua 3): a compound heterozygous between true deficiency (Gly(380)-->Arg) and an abnormality (Ser(334)-->Pro).",
"journal": "Thrombosis research",
"date": "2001",
"authors": "Vianello F, Lombardi AM, Boldrin C, Luni S, Girolami A",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "11728527",
"url": "https://glygen.org/publication/PubMed/11728527"
}
]
},
{
"title": "Identification and characterization of prolylcarboxypeptidase as an endothelial cell prekallikrein activator.",
"journal": "The Journal of biological chemistry",
"date": "2002",
"authors": "Shariat-Madar Z, Mahdi F, Schmaier AH",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "11830581",
"url": "https://glygen.org/publication/PubMed/11830581"
}
]
},
{
"title": "Bivalirudin: a direct thrombin inhibitor.",
"journal": "Clinical therapeutics",
"date": "2002",
"authors": "Gladwell TD",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "11833835",
"url": "https://glygen.org/publication/PubMed/11833835"
}
]
},
{
"title": "Factor XII interacts with the multiprotein assembly of urokinase plasminogen activator receptor, gC1qR, and cytokeratin 1 on endothelial cell membranes.",
"journal": "Blood",
"date": "2002",
"authors": "Mahdi F, Madar ZS, Figueroa CD, Schmaier AH",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "11986212",
"url": "https://glygen.org/publication/PubMed/11986212"
}
]
},
{
"title": "Activation of endothelial cell protease activated receptor 1 by the protein C pathway.",
"journal": "Science (New York, N.Y.)",
"date": "2002",
"authors": "Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140875",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875"
}
],
"reference": [
{
"type": "PubMed",
"id": "12052963",
"url": "https://glygen.org/publication/PubMed/12052963"
}
]
},
{
"title": "Mutations associated with hemophilia A in the 558-565 loop of the factor VIIIa A2 subunit alter the catalytic activity of the factor Xase complex.",
"journal": "Blood",
"date": "2002",
"authors": "Jenkins PV, Freas J, Schmidt KM, Zhou Q, Fay PJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9672396",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9672396"
}
],
"reference": [
{
"type": "PubMed",
"id": "12091341",
"url": "https://glygen.org/publication/PubMed/12091341"
}
]
},
{
"title": "Identification of prolylcarboxypeptidase as the cell matrix-associated prekallikrein activator.",
"journal": "FEBS letters",
"date": "2002",
"authors": "Moreira CR, Schmaier AH, Mahdi F, da Motta G, Nader HB, Shariat-Madar Z",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "12123826",
"url": "https://glygen.org/publication/PubMed/12123826"
}
]
},
{
"title": "Localization of the adhesion receptor glycoprotein Ib-IX-V complex to lipid rafts is required for platelet adhesion and activation.",
"journal": "The Journal of experimental medicine",
"date": "2002",
"authors": "Shrimpton CN, Borthakur G, Larrucea S, Cruz MA, Dong JF, Lopez JA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "12391017",
"url": "https://glygen.org/publication/PubMed/12391017"
}
]
},
{
"title": "Impaired prothrombinase activity of factor X Gly381Asp results in severe familial CRM+ FX deficiency.",
"journal": "Thrombosis and haemostasis",
"date": "2003",
"authors": "Pinotti M, Camire RM, Baroni M, Rajab A, Marchetti G, Bernardi F",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "12574802",
"url": "https://glygen.org/publication/PubMed/12574802"
}
]
},
{
"title": "Heparin-induced substrate behavior of antithrombin Cambridge II.",
"journal": "Blood",
"date": "2003",
"authors": "Mushunje A, Zhou A, Carrell RW, Huntington JA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140875",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875"
}
],
"reference": [
{
"type": "PubMed",
"id": "12907439",
"url": "https://glygen.org/publication/PubMed/12907439"
}
]
},
{
"title": "The relative priority of prekallikrein and factors XI/XIa assembly on cultured endothelial cells.",
"journal": "The Journal of biological chemistry",
"date": "2003",
"authors": "Mahdi F, Shariat-Madar Z, Schmaier AH",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "12944405",
"url": "https://glygen.org/publication/PubMed/12944405"
}
]
},
{
"title": "A novel type I factor X variant (factor X Cys350Phe) due to loss of a disulfide bond in the catalytic domain.",
"journal": "Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis",
"date": "2003",
"authors": "Vianello F, Lombardi AM, Bello FD, Palu G, Zanon E, Girolami A",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "12945883",
"url": "https://glygen.org/publication/PubMed/12945883"
}
]
},
{
"title": "Hemophilia B caused by five different nondeletion mutations in the protease domain of factor IX.",
"journal": "Blood",
"date": "1992",
"authors": "Ludwig M, Sabharwal AK, Brackmann HH, Olek K, Smith KJ, Birktoft JJ, Bajaj SP",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9673202",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9673202"
}
],
"reference": [
{
"type": "PubMed",
"id": "1346975",
"url": "https://glygen.org/publication/PubMed/1346975"
}
]
},
{
"title": "The physiologic basis of assembly and activation of the plasma kallikrein/kinin system.",
"journal": "Thrombosis and haemostasis",
"date": "2004",
"authors": "Schmaier AH",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "14691562",
"url": "https://glygen.org/publication/PubMed/14691562"
}
]
},
{
"title": "The factor V activation paradox.",
"journal": "The Journal of biological chemistry",
"date": "2004",
"authors": "Orfeo T, Brufatto N, Nesheim ME, Xu H, Butenas S, Mann KG",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140875",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875"
}
],
"reference": [
{
"type": "PubMed",
"id": "14982929",
"url": "https://glygen.org/publication/PubMed/14982929"
}
]
},
{
"title": "Recombinant prolylcarboxypeptidase activates plasma prekallikrein.",
"journal": "Blood",
"date": "2004",
"authors": "Shariat-Madar Z, Mahdi F, Schmaier AH",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "14996700",
"url": "https://glygen.org/publication/PubMed/14996700"
}
]
},
{
"title": "Molecular characterization of factor X deficiency associated with borderline plasma factor X level.",
"journal": "Haematologica",
"date": "2004",
"authors": "Pinotti M, Monti M, Baroni M, Marchetti G, Bernardi F",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "15075089",
"url": "https://glygen.org/publication/PubMed/15075089"
}
]
},
{
"title": "Genetic analysis of hereditary factor X deficiency in a French patient of Sri Lankan ancestry: in vitro expression study identified Gly366Ser substitution as the molecular basis of the dysfunctional factor X.",
"journal": "Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis",
"date": "2005",
"authors": "Isshiki I, Favier R, Moriki T, Uchida T, Ishihara H, Van Dreden P, Murata M, Ikeda Y",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "15650540",
"url": "https://glygen.org/publication/PubMed/15650540"
}
]
},
{
"title": "Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3- [4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939): an oral, direct factor Xa inhibitor.",
"journal": "Journal of medicinal chemistry",
"date": "2005",
"authors": "Roehrig S, Straub A, Pohlmann J, Lampe T, Pernerstorfer J, Schlemmer KH, Reinemer P, Perzborn E",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140875",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875"
}
],
"reference": [
{
"type": "PubMed",
"id": "16161994",
"url": "https://glygen.org/publication/PubMed/16161994"
}
]
},
{
"title": "Characterization of the interaction between the A2 subunit and A1/A3-C1-C2 dimer in human factor VIIIa.",
"journal": "The Journal of biological chemistry",
"date": "1992",
"authors": "Fay PJ, Smudzin TM",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "1618828",
"url": "https://glygen.org/publication/PubMed/1618828"
}
]
},
{
"title": "Substituted thiophene-anthranilamides as potent inhibitors of human factor Xa.",
"journal": "Bioorg. Med. Chem.",
"date": "2007",
"authors": "Kochanny Monica J, Adler Marc, Ewing Janice, Griedel Brian D, Ho Elena, Karanjawala Rushad, Lee Wheeseong, Lentz Dao, Liang Amy M, Morrissey Michael M, Phillips Gary B, Post Joseph, Sacchi Karna L, Sakata Steven T, Subramanyam Babu, Vergona Ron, Walters Janette, White Kathy A, Whitlow Marc, Ye Bin, Zhao Zuchun, Shaw Kenneth J",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "17227710",
"url": "https://glygen.org/publication/PubMed/17227710"
}
]
},
{
"title": "Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane.",
"journal": "The Journal of biological chemistry",
"date": "1992",
"authors": "Modderman PW, Admiraal LG, Sonnenberg A, von dem Borne AE",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "1730602",
"url": "https://glygen.org/publication/PubMed/1730602"
}
]
},
{
"title": "Analysis of the novel factor X gene mutation Glu51Lys in two families with factor X-Riyadh anomaly.",
"journal": "Thrombosis and haemostasis",
"date": "2007",
"authors": "Al-Hilali A, Wulff K, Abdel-Razeq H, Saud KA, Al-Gaili F, Herrmann FH",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "17393015",
"url": "https://glygen.org/publication/PubMed/17393015"
}
]
},
{
"title": "The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects.",
"journal": "British journal of clinical pharmacology",
"date": "2007",
"authors": "Stangier J, Rathgen K, Stahle H, Gansser D, Roth W",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "17506785",
"url": "https://glygen.org/publication/PubMed/17506785"
}
]
},
{
"title": "In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate.",
"journal": "Thrombosis and haemostasis",
"date": "2007",
"authors": "Wienen W, Stassen JM, Priepke H, Ries UJ, Hauel N",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "17598008",
"url": "https://glygen.org/publication/PubMed/17598008"
}
]
},
{
"title": "Activated protein C.",
"journal": "Journal of thrombosis and haemostasis : JTH",
"date": "2007",
"authors": "Griffin JH, Fernandez JA, Gale AJ, Mosnier LO",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140875",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875"
}
],
"reference": [
{
"type": "PubMed",
"id": "17635713",
"url": "https://glygen.org/publication/PubMed/17635713"
}
]
},
{
"title": "Characterization of factor VII association with tissue factor in solution. High and low affinity calcium binding sites in factor VII contribute to functionally distinct interactions.",
"journal": "The Journal of biological chemistry",
"date": "1991",
"authors": "Ruf W, Kalnik MW, Lund-Hansen T, Edgington TS",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140834",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834"
}
],
"reference": [
{
"type": "PubMed",
"id": "1874730",
"url": "https://glygen.org/publication/PubMed/1874730"
}
]
},
{
"title": "Cloning and expression in COS-1 cells of a full-length cDNA encoding human coagulation factor X.",
"journal": "Gene",
"date": "1991",
"authors": "Messier T L, Pittman D D, Long G L, Kaufman R J, Church W R",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "1902434",
"url": "https://glygen.org/publication/PubMed/1902434"
}
]
},
{
"title": "Human factor VIIIa subunit structure. Reconstruction of factor VIIIa from the isolated A1/A3-C1-C2 dimer and A2 subunit.",
"journal": "The Journal of biological chemistry",
"date": "1991",
"authors": "Fay PJ, Haidaris PJ, Smudzin TM",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "1902833",
"url": "https://glygen.org/publication/PubMed/1902833"
}
]
},
{
"title": "Characterization of a homozygous Gly11Val mutation in the Gla domain of coagulation factor X.",
"journal": "Thrombosis research",
"date": "2009",
"authors": "Chafa O, Tagzirt M, Tapon-Bretaudiere J, Reghis A, Fischer AM, LeBonniec BF",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "19135706",
"url": "https://glygen.org/publication/PubMed/19135706"
}
]
},
{
"title": "Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenz amide, a highly potent, selective, and orally efficacious factor Xa inhibitor.",
"journal": "Bioorganic & medicinal chemistry letters",
"date": "2009",
"authors": "Zhang P, Huang W, Wang L, Bao L, Jia ZJ, Bauer SM, Goldman EA, Probst GD, Song Y, Su T, Fan J, Wu Y, Li W, Woolfrey J, Sinha U, Wong PW, Edwards ST, Arfsten AE, Clizbe LA, Kanter J, Pandey A, Park G, Hutchaleelaha A, Lambing JL, Hollenbach SJ, Scarborough RM, Zhu BY",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140875",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875"
}
],
"reference": [
{
"type": "PubMed",
"id": "19297154",
"url": "https://glygen.org/publication/PubMed/19297154"
}
]
},
{
"title": "Inhibition of the thrombin-platelet reactions by DuP 714.",
"journal": "Biochemical and biophysical research communications",
"date": "1991",
"authors": "Chiu AT, Mousa SA, Pease LJ, Roscoe WA, Bozarth JM, Reilly TM, Smith RD, Timmermans PB",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "1930190",
"url": "https://glygen.org/publication/PubMed/1930190"
}
]
},
{
"title": "Factor IX Amagasaki: a new mutation in the catalytic domain resulting in the loss of both coagulant and esterase activities.",
"journal": "Biochemistry",
"date": "1991",
"authors": "Miyata T, Sakai T, Sugimoto M, Naka H, Yamamoto K, Yoshioka A, Fukui H, Mitsui K, Kamiya K, Umeyama H, et al.",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9673202",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9673202"
}
],
"reference": [
{
"type": "PubMed",
"id": "1958666",
"url": "https://glygen.org/publication/PubMed/1958666"
}
]
},
{
"title": "Molecular defect (Gla+14----Lys) and its functional consequences in a hereditary factor X deficiency (factor X `Vorarlberg`).",
"journal": "The Journal of biological chemistry",
"date": "1990",
"authors": "Watzke HH, Lechner K, Roberts HR, Reddy SV, Welsch DJ, Friedman P, Mahr G, Jagadeeswaran P, Monroe DM, High KA",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "1973167",
"url": "https://glygen.org/publication/PubMed/1973167"
}
]
},
{
"title": "X-linked thrombophilia with a mutant factor IX (factor IX Padua).",
"journal": "The New England journal of medicine",
"date": "2009",
"authors": "Simioni P, Tormene D, Tognin G, Gavasso S, Bulato C, Iacobelli NP, Finn JD, Spiezia L, Radu C, Arruda VR",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9672383",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9672383"
}
],
"reference": [
{
"type": "PubMed",
"id": "19846852",
"url": "https://glygen.org/publication/PubMed/19846852"
}
]
},
{
"title": "Molecular defect in coagulation factor XFriuli results from a substitution of serine for proline at position 343.",
"journal": "Blood",
"date": "1991",
"authors": "James HL, Girolami A, Fair DS",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "1985698",
"url": "https://glygen.org/publication/PubMed/1985698"
}
]
},
{
"title": "Location of the disulfide bonds in human coagulation factor XI: the presence of tandem apple domains.",
"journal": "Biochemistry",
"date": "1991",
"authors": "McMullen BA, Fujikawa K, Davie EW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "1998667",
"url": "https://glygen.org/publication/PubMed/1998667"
}
]
},
{
"title": "Activation of human blood coagulation factor XI independent of factor XII. Factor XI is activated by thrombin and factor XIa in the presence of negatively charged surfaces.",
"journal": "The Journal of biological chemistry",
"date": "1991",
"authors": "Naito K, Fujikawa K",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "2019570",
"url": "https://glygen.org/publication/PubMed/2019570"
}
]
},
{
"title": "Cooperative activation of human factor IX by the human extrinsic pathway of blood coagulation.",
"journal": "The Journal of biological chemistry",
"date": "1991",
"authors": "Lawson JH, Mann KG",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140834",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834"
}
],
"reference": [
{
"type": "PubMed",
"id": "2040636",
"url": "https://glygen.org/publication/PubMed/2040636"
}
]
},
{
"title": "Basis for the specificity and activation of the serpin protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-associated factor Xa.",
"journal": "J. Biol. Chem.",
"date": "2010",
"authors": "Huang X, Dementiev A, Olson ST, Gettins PG",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "20427285",
"url": "https://glygen.org/publication/PubMed/20427285"
}
]
},
{
"title": "Binding of human factor VIII to phospholipid vesicles.",
"journal": "The Journal of biological chemistry",
"date": "1990",
"authors": "Gilbert GE, Furie BC, Furie B",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "2104832",
"url": "https://glygen.org/publication/PubMed/2104832"
}
]
},
{
"title": "Replacement of isoleucine-397 by threonine in the clotting proteinase factor IXa (Los Angeles and Long Beach variants) affects macromolecular catalysis but not L-tosylarginine methyl ester hydrolysis. Lack of correlation between the ox brain prothrombin time and the mutation site in the variant proteins.",
"journal": "The Biochemical journal",
"date": "1990",
"authors": "Spitzer SG, Warn-Cramer BJ, Kasper CK, Bajaj SP",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9673202",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9673202"
}
],
"reference": [
{
"type": "PubMed",
"id": "2105717",
"url": "https://glygen.org/publication/PubMed/2105717"
}
]
},
{
"title": "Kinetics of coagulation factor X activation by platelet-bound factor IXa.",
"journal": "Biochemistry",
"date": "1990",
"authors": "Rawala-Sheikh R, Ahmad SS, Ashby B, Walsh PN",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "2110473",
"url": "https://glygen.org/publication/PubMed/2110473"
}
]
},
{
"title": "Analysis of serpin secretion, misfolding, and surveillance in the endoplasmic reticulum.",
"journal": "Methods in enzymology",
"date": "2011",
"authors": "Pan S, Iannotti MJ, Sifers RN",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "21683246",
"url": "https://glygen.org/publication/PubMed/21683246"
}
]
},
{
"title": "Desirudin: a review of the pharmacology and clinical application for the prevention of deep vein thrombosis.",
"journal": "Expert review of cardiovascular therapy",
"date": "2011",
"authors": "Graetz TJ, Tellor BR, Smith JR, Avidan MS",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "21932952",
"url": "https://glygen.org/publication/PubMed/21932952"
}
]
},
{
"title": "Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.",
"journal": "Molecular & cellular proteomics : MCP",
"date": "2012",
"authors": "Halim A, Nilsson J, Ruetschi U, Hesse C, Larson G",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
},
{
"database": "UniCarbKB",
"id": "P00742",
"url": ""
}
],
"reference": [
{
"type": "PubMed",
"id": "22171320",
"url": "https://glygen.org/publication/PubMed/22171320"
}
]
},
{
"title": "Proteolytic activation of human factors IX and X by recombinant human factor VIIa: effects of calcium, phospholipids, and tissue factor.",
"journal": "Biochemistry",
"date": "1990",
"authors": "Komiyama Y, Pedersen AH, Kisiel W",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140834",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834"
}
],
"reference": [
{
"type": "PubMed",
"id": "2248955",
"url": "https://glygen.org/publication/PubMed/2248955"
}
]
},
{
"title": "Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.",
"journal": "Blood",
"date": "2012",
"authors": "Li W, Huntington JA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140875",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875"
}
],
"reference": [
{
"type": "PubMed",
"id": "22618708",
"url": "https://glygen.org/publication/PubMed/22618708"
}
]
},
{
"title": "Structural biology of factor VIIa/tissue factor initiated coagulation.",
"journal": "Frontiers in bioscience (Landmark edition)",
"date": "2012",
"authors": "Vadivel K, Bajaj SP",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140834",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834"
}
],
"reference": [
{
"type": "PubMed",
"id": "22652793",
"url": "https://glygen.org/publication/PubMed/22652793"
}
]
},
{
"title": "Regulation of coagulation by a multivalent Kunitz-type inhibitor.",
"journal": "Biochemistry",
"date": "1990",
"authors": "Broze GJ Jr, Girard TJ, Novotny WF",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140834",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834"
}
],
"reference": [
{
"type": "PubMed",
"id": "2271516",
"url": "https://glygen.org/publication/PubMed/2271516"
}
]
},
{
"title": "A sequential mechanism for exosite-mediated factor IX activation by factor XIa.",
"journal": "The Journal of biological chemistry",
"date": "2012",
"authors": "Geng Y, Verhamme IM, Messer A, Sun MF, Smith SB, Bajaj SP, Gailani D",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "22961984",
"url": "https://glygen.org/publication/PubMed/22961984"
}
]
},
{
"title": "Regulation of tissue factor coagulant activity on cell surfaces.",
"journal": "Journal of thrombosis and haemostasis : JTH",
"date": "2012",
"authors": "Rao LV, Pendurthi UR",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140834",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834"
}
],
"reference": [
{
"type": "PubMed",
"id": "23006890",
"url": "https://glygen.org/publication/PubMed/23006890"
}
]
},
{
"title": "Experimental and theoretical evidence supporting the role of Gly363 in blood coagulation factor IXa (Gly193 in chymotrypsin) for proper activation of the proenzyme.",
"journal": "The Journal of biological chemistry",
"date": "1990",
"authors": "Bajaj SP, Spitzer SG, Welsh WJ, Warn-Cramer BJ, Kasper CK, Birktoft JJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9673202",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9673202"
}
],
"reference": [
{
"type": "PubMed",
"id": "2303434",
"url": "https://glygen.org/publication/PubMed/2303434"
}
]
},
{
"title": "Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology.",
"journal": "The EMBO journal",
"date": "2013",
"authors": "Steentoft C, Vakhrushev SY, Joshi HJ, Kong Y, Vester-Christensen MB, Schjoldager KT, Lavrsen K, Dabelsteen S, Pedersen NB, Marcos-Silva L, Gupta R, Bennett EP, Mandel U, Brunak S, Wandall HH, Levery SB, Clausen H",
"evidence": [
{
"database": "UniCarbKB",
"id": "P00742",
"url": ""
}
],
"reference": [
{
"type": "PubMed",
"id": "23584533",
"url": "https://glygen.org/publication/PubMed/23584533"
}
]
},
{
"title": "Analysis of tissue factor expression in various cell model systems: cryptic vs. active.",
"journal": "Journal of thrombosis and haemostasis : JTH",
"date": "2013",
"authors": "Kothari H, Pendurthi UR, Rao LV",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140834",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834"
}
],
"reference": [
{
"type": "PubMed",
"id": "23621622",
"url": "https://glygen.org/publication/PubMed/23621622"
}
]
},
{
"title": "The missense Thr211Pro mutation in the factor X activation peptide of a bleeding patient causes molecular defect in the clotting cascade.",
"journal": "Thrombosis and haemostasis",
"date": "2013",
"authors": "Ding Q, Shen Y, Yang L, Wang X, Rezaie AR",
"evidence": [
{
"database": "Automatic Literature Mining",
"id": "23677006",
"url": "https://research.bioinformatics.udel.edu/glyco/pmid/23677006"
}
],
"reference": [
{
"type": "PubMed",
"id": "23677006",
"url": "https://glygen.org/publication/PubMed/23677006"
}
]
},
{
"title": "Efficacy and toxicity of factor Xa inhibitors.",
"journal": "Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques",
"date": "2013",
"authors": "Bondarenko M, Curti C, Montana M, Rathelot P, Vanelle P",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140875",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875"
}
],
"reference": [
{
"type": "PubMed",
"id": "23683607",
"url": "https://glygen.org/publication/PubMed/23683607"
}
]
},
{
"title": "Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors.",
"journal": "The Journal of clinical investigation",
"date": "1990",
"authors": "Weitz JI, Hudoba M, Massel D, Maraganore J, Hirsh J",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "2384594",
"url": "https://glygen.org/publication/PubMed/2384594"
}
]
},
{
"title": "The new factor Xa inhibitor: Apixaban.",
"journal": "Journal of pharmacology & pharmacotherapeutics",
"date": "2014",
"authors": "Bhanwra S, Ahluwalia K",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140875",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875"
}
],
"reference": [
{
"type": "PubMed",
"id": "24554904",
"url": "https://glygen.org/publication/PubMed/24554904"
}
]
},
{
"title": "In situ-generated thrombin is the only enzyme that effectively activates factor VIII and factor V in thromboplastin-activated plasma.",
"journal": "Blood",
"date": "1989",
"authors": "Pieters J, Lindhout T, Hemker HC",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "2502206",
"url": "https://glygen.org/publication/PubMed/2502206"
}
]
},
{
"title": "Differential proteolytic activation of factor VIII-von Willebrand factor complex by thrombin.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "1989",
"authors": "Hill-Eubanks DC, Parker CG, Lollar P",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "2505252",
"url": "https://glygen.org/publication/PubMed/2505252"
}
]
},
{
"title": "Molecular dynamics characterization of five pathogenic Factor X mutants associated with decreased catalytic activity.",
"journal": "Biochemistry",
"date": "2014",
"authors": "Abdel-Azeim S, Oliva R, Chermak E, De Cristofaro R, Cavallo L",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "25313940",
"url": "https://glygen.org/publication/PubMed/25313940"
}
]
},
{
"title": "The roles of protein C and thrombomodulin in the regulation of blood coagulation.",
"journal": "The Journal of biological chemistry",
"date": "1989",
"authors": "Esmon CT",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140875",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875"
}
],
"reference": [
{
"type": "PubMed",
"id": "2538457",
"url": "https://glygen.org/publication/PubMed/2538457"
}
]
},
{
"title": "GGCX and VKORC1 inhibit osteocalcin endocrine functions.",
"journal": "The Journal of cell biology",
"date": "2015",
"authors": "Ferron M, Lacombe J, Germain A, Oury F, Karsenty G",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-159740",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159740"
}
],
"reference": [
{
"type": "PubMed",
"id": "25753038",
"url": "https://glygen.org/publication/PubMed/25753038"
}
]
},
{
"title": "The regulation of human factor XIIa by plasma proteinase inhibitors.",
"journal": "The Journal of biological chemistry",
"date": "1985",
"authors": "Pixley RA, Schapira M, Colman RW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "2578463",
"url": "https://glygen.org/publication/PubMed/2578463"
}
]
},
{
"title": "Distribution of plasma kallikrein between C-1 inactivator and alpha 2-macroglobulin in plasma utilizing a new assay for alpha 2-macroglobulin-kallikrein complexes.",
"journal": "The Journal of biological chemistry",
"date": "1985",
"authors": "Harpel PC, Lewin MF, Kaplan AP",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "2579948",
"url": "https://glygen.org/publication/PubMed/2579948"
}
]
},
{
"title": "Characterization of an almost full-length cDNA coding for human blood coagulation factor X.",
"journal": "Proc. Natl. Acad. Sci. U.S.A.",
"date": "1985",
"authors": "Fung M R, Hay C W, MacGillivray R T",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "2582420",
"url": "https://glygen.org/publication/PubMed/2582420"
}
]
},
{
"title": "Edoxaban, a Novel Oral Factor Xa Inhibitor.",
"journal": "The Annals of pharmacotherapy",
"date": "2015",
"authors": "Minor C, Tellor KB, Armbruster AL",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140875",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875"
}
],
"reference": [
{
"type": "PubMed",
"id": "25855704",
"url": "https://glygen.org/publication/PubMed/25855704"
}
]
},
{
"title": "Expression and Characterization of Gly-317 Variants of Factor IX Causing Variable Bleeding in Hemophilia B Patients.",
"journal": "Biochemistry",
"date": "2015",
"authors": "Lu Q, Yang L, Manithody C, Wang X, Rezaie AR",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9673202",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9673202"
}
],
"reference": [
{
"type": "PubMed",
"id": "26023895",
"url": "https://glygen.org/publication/PubMed/26023895"
}
]
},
{
"title": "Cloning and characterization of the 5' end (exon 1) of the gene encoding human factor X.",
"journal": "Gene",
"date": "1989",
"authors": "Jagadeeswaran P, Reddy S V, Rao K J, Hamsabhushanam K, Lyman G",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "2612918",
"url": "https://glygen.org/publication/PubMed/2612918"
}
]
},
{
"title": "Frequency of the p.Gly262Asp mutation in congenital Factor X deficiency.",
"journal": "European journal of clinical investigation",
"date": "2015",
"authors": "Epcacan S, Menegatti M, Akbayram S, Cairo A, Peyvandi F, Oner AF",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "26222694",
"url": "https://glygen.org/publication/PubMed/26222694"
}
]
},
{
"title": "Factor VIII Is Synthesized in Human Endothelial Cells, Packaged in Weibel-Palade Bodies and Secreted Bound to ULVWF Strings.",
"journal": "PloS one",
"date": "2015",
"authors": "Turner NA, Moake JL",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "26473492",
"url": "https://glygen.org/publication/PubMed/26473492"
}
]
},
{
"title": "Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone.",
"journal": "Physiological reviews",
"date": "1989",
"authors": "Hauschka PV, Lian JB, Cole DE, Gundberg CM",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-159740",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159740"
}
],
"reference": [
{
"type": "PubMed",
"id": "2664828",
"url": "https://glygen.org/publication/PubMed/2664828"
}
]
},
{
"title": "Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "1989",
"authors": "Wilcox JN, Smith KM, Schwartz SM, Gordon D",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140834",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834"
}
],
"reference": [
{
"type": "PubMed",
"id": "2704749",
"url": "https://glygen.org/publication/PubMed/2704749"
}
]
},
{
"title": "Factor IX San Dimas. Substitution of glutamine for Arg-4 in the propeptide leads to incomplete gamma-carboxylation and altered phospholipid binding properties.",
"journal": "The Journal of biological chemistry",
"date": "1989",
"authors": "Ware J, Diuguid DL, Liebman HA, Rabiet MJ, Kasper CK, Furie BC, Furie B, Stafford DW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-159740",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159740"
}
],
"reference": [
{
"type": "PubMed",
"id": "2738071",
"url": "https://glygen.org/publication/PubMed/2738071"
}
]
},
{
"title": "High-resolution NMR studies of fibrinogen-like peptides in solution: interaction of thrombin with residues 1-23 of the A alpha chain of human fibrinogen.",
"journal": "Biochemistry",
"date": "1989",
"authors": "Ni F, Konishi Y, Frazier RB, Scheraga HA, Lord ST",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140875",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875"
}
],
"reference": [
{
"type": "PubMed",
"id": "2742826",
"url": "https://glygen.org/publication/PubMed/2742826"
}
]
},
{
"title": "Molecular characterization of human factor XSan Antonio.",
"journal": "Blood",
"date": "1989",
"authors": "Reddy SV, Zhou ZQ, Rao KJ, Scott JP, Watzke H, High KA, Jagadeeswaran P",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "2790181",
"url": "https://glygen.org/publication/PubMed/2790181"
}
]
},
{
"title": "Purification and properties of prolylcarboxypeptidase (angiotensinase C) from human kidney.",
"journal": "The Journal of biological chemistry",
"date": "1978",
"authors": "Odya CE, Marinkovic DV, Hammon KJ, Stewart TA, Erdos EG",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "28321",
"url": "https://glygen.org/publication/PubMed/28321"
}
]
},
{
"title": "Regulation of formation of factor XIIIa by its fibrin substrates.",
"journal": "Biochemistry",
"date": "1985",
"authors": "Lewis SD, Janus TJ, Lorand L, Shafer JA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140875",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875"
}
],
"reference": [
{
"type": "PubMed",
"id": "2866798",
"url": "https://glygen.org/publication/PubMed/2866798"
}
]
},
{
"title": "An update on factor XI structure and function.",
"journal": "Thrombosis research",
"date": "2018",
"authors": "Mohammed BM, Matafonov A, Ivanov I, Sun MF, Cheng Q, Dickeson SK, Li C, Sun D, Verhamme IM, Emsley J, Gailani D",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "29223926",
"url": "https://glygen.org/publication/PubMed/29223926"
}
]
},
{
"title": "Tissue Factor: An Essential Mediator of Hemostasis and Trigger of Thrombosis.",
"journal": "Arteriosclerosis, thrombosis, and vascular biology",
"date": "2018",
"authors": "Grover SP, Mackman N",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140834",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834"
}
],
"reference": [
{
"type": "PubMed",
"id": "29437578",
"url": "https://glygen.org/publication/PubMed/29437578"
}
]
},
{
"title": "Isolation and characterization of human blood-coagulation factor X cDNA.",
"journal": "Gene",
"date": "1986",
"authors": "Kaul R K, Hildebrand B, Roberts S, Jagadeeswaran P",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "3011603",
"url": "https://glygen.org/publication/PubMed/3011603"
}
]
},
{
"title": "Binding of coagulation factor XI to washed human platelets.",
"journal": "Biochemistry",
"date": "1986",
"authors": "Greengard JS, Heeb MJ, Ersdal E, Walsh PN, Griffin JH",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "3017409",
"url": "https://glygen.org/publication/PubMed/3017409"
}
]
},
{
"title": "Mapping the O-glycoproteome using site-specific extraction of O-linked glycopeptides (EXoO).",
"journal": "Molecular systems biology",
"date": "2018",
"authors": "Yang W, Ao M, Hu Y, Li QK, Zhang H",
"evidence": [
{
"database": "UniCarbKB",
"id": "P00742",
"url": ""
}
],
"reference": [
{
"type": "PubMed",
"id": "30459171",
"url": "https://glygen.org/publication/PubMed/30459171"
}
]
},
{
"title": "Cofactor proteins in the assembly and expression of blood clotting enzyme complexes.",
"journal": "Annual review of biochemistry",
"date": "1988",
"authors": "Mann KG, Jenny RJ, Krishnaswamy S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140875",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875"
}
],
"reference": [
{
"type": "PubMed",
"id": "3052293",
"url": "https://glygen.org/publication/PubMed/3052293"
}
]
},
{
"title": "Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activity.",
"journal": "Biochemistry",
"date": "1986",
"authors": "Eaton D, Rodriguez H, Vehar GA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "3082357",
"url": "https://glygen.org/publication/PubMed/3082357"
}
]
},
{
"title": "Biosynthesis of complement C1 inhibitor by Hep G2 cells. Reactivity of different glycosylated forms of the inhibitor with C1s.",
"journal": "The Biochemical journal",
"date": "1986",
"authors": "Prandini MH, Reboul A, Colomb MG",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "3099750",
"url": "https://glygen.org/publication/PubMed/3099750"
}
]
},
{
"title": "Allostery in Coagulation Factor VIIa Revealed by Ensemble Refinement of Crystallographic Structures.",
"journal": "Biophysical journal",
"date": "2019",
"authors": "Sorensen AB, Madsen JJ, Frimurer TM, Overgaard MT, Gandhi PS, Persson E, Olsen OH",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140834",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834"
}
],
"reference": [
{
"type": "PubMed",
"id": "31003762",
"url": "https://glygen.org/publication/PubMed/31003762"
}
]
},
{
"title": "Synthesis, processing, and secretion of recombinant human factor VIII expressed in mammalian cells.",
"journal": "The Journal of biological chemistry",
"date": "1988",
"authors": "Kaufman RJ, Wasley LC, Dorner AJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "3129422",
"url": "https://glygen.org/publication/PubMed/3129422"
}
]
},
{
"title": "Association of the factor VIII light chain with von Willebrand factor.",
"journal": "The Journal of biological chemistry",
"date": "1988",
"authors": "Lollar P, Hill-Eubanks DC, Parker CG",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "3134349",
"url": "https://glygen.org/publication/PubMed/3134349"
}
]
},
{
"title": "Tissue factor and hemostasis.",
"journal": "Blood",
"date": "1988",
"authors": "Nemerson Y",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140834",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834"
}
],
"reference": [
{
"type": "PubMed",
"id": "3275472",
"url": "https://glygen.org/publication/PubMed/3275472"
}
]
},
{
"title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.",
"journal": "Biochimica et biophysica acta. General subjects",
"date": "2021",
"authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y",
"evidence": [
{
"database": "O-GlcNAc Database",
"id": "P00742",
"url": "https://www.oglcnac.mcw.edu/search/?query_protein=P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "34019948",
"url": "https://glygen.org/publication/PubMed/34019948"
}
]
},
{
"title": "Completion of the primary structure of human high-molecular-mass kininogen. The amino acid sequence of the entire heavy chain and evidence for its evolution by gene triplication.",
"journal": "European journal of biochemistry",
"date": "1986",
"authors": "Kellermann J, Lottspeich F, Henschen A, Muller-Esterl W",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "3484703",
"url": "https://glygen.org/publication/PubMed/3484703"
}
]
},
{
"title": "Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats.",
"journal": "Biochemistry",
"date": "1986",
"authors": "Chung DW, Fujikawa K, McMullen BA, Davie EW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "3521732",
"url": "https://glygen.org/publication/PubMed/3521732"
}
]
},
{
"title": "Amino acid sequence of human von Willebrand factor.",
"journal": "Biochemistry",
"date": "1986",
"authors": "Titani K, Kumar S, Takio K, Ericsson LH, Wade RD, Ashida K, Walsh KA, Chopek MW, Sadler JE, Fujikawa K",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "3524673",
"url": "https://glygen.org/publication/PubMed/3524673"
}
]
},
{
"title": "Factor VII binding to tissue factor in reconstituted phospholipid vesicles: induction of cooperativity by phosphatidylserine.",
"journal": "Biochemistry",
"date": "1986",
"authors": "Bach R, Gentry R, Nemerson Y",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140834",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834"
}
],
"reference": [
{
"type": "PubMed",
"id": "3527261",
"url": "https://glygen.org/publication/PubMed/3527261"
}
]
},
{
"title": "Spike Protein Subunits of SARS-CoV-2 Alter Mitochondrial Metabolism in Human Pulmonary Microvascular Endothelial Cells: Involvement of Factor Xa.",
"journal": "Disease markers",
"date": "2022",
"authors": "Zekri-Nechar Khaoula, Zamorano-Le\u00f3n Jos\u00e9 J, Reche Carmen, Giner Manel, L\u00f3pez-de-Andr\u00e9s Ana, Jim\u00e9nez-Garc\u00eda Rodrigo, L\u00f3pez-Farr\u00e9 Antonio J, Mart\u00ednez-Mart\u00ednez Carlos Hugo",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000495",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000495"
}
],
"reference": [
{
"type": "PubMed",
"id": "36438904",
"url": "https://glygen.org/publication/PubMed/36438904"
}
]
},
{
"title": "Influence of Heparan Sulfate Proteoglycans and Factor X on species D Human Adenovirus Uptake and Transduction.",
"journal": "Viruses",
"date": "2022-12-24",
"authors": "Schr\u00f6er Katrin, Alshawabkeh Montaha, Schellhorn Sebastian, Bronder Katrin, Zhang Wenli, Ehrhardt Anja",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000495",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000495"
}
],
"reference": [
{
"type": "PubMed",
"id": "36680095",
"url": "https://glygen.org/publication/PubMed/36680095"
}
]
},
{
"title": "Factor Xa cleaves SARS-CoV-2 spike protein to block viral entry and infection.",
"journal": "Nature communications",
"date": "2023-04-06",
"authors": "Dong Wenjuan, Wang Jing, Tian Lei, Zhang Jianying, Settles Erik W, Qin Chao, Steinken-Kollath Daniel R, Itogawa Ashley N, Celona Kimberly R, Yi Jinhee, Bryant Mitchell, Mead Heather, Jaramillo Sierra A, Lu Hongjia, Li Aimin, Zumwalt Ross E, Dadwal Sanjeet, Feng Pinghui, Yuan Weiming, Whelan Sean P J, Keim Paul S, Barker Bridget Marie, Caligiuri Michael A, Yu Jianhua",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000495",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000495"
}
],
"reference": [
{
"type": "PubMed",
"id": "37024459",
"url": "https://glygen.org/publication/PubMed/37024459"
}
]
},
{
"title": "Expression, purification, and characterization of recombinant gamma-carboxylated factor IX synthesized in Chinese hamster ovary cells.",
"journal": "The Journal of biological chemistry",
"date": "1986",
"authors": "Kaufman RJ, Wasley LC, Furie BC, Furie B, Shoemaker CB",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "3733688",
"url": "https://glygen.org/publication/PubMed/3733688"
}
]
},
{
"title": "Heparin and its low molecular weight derivatives: anticoagulant and antithrombotic properties.",
"journal": "Haemostasis",
"date": "1986",
"authors": "Holmer E, Soderberg K, Bergqvist D, Lindahl U",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140875",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875"
}
],
"reference": [
{
"type": "PubMed",
"id": "3744129",
"url": "https://glygen.org/publication/PubMed/3744129"
}
]
},
{
"title": "Human C1 inhibitor: primary structure, cDNA cloning, and chromosomal localization.",
"journal": "Biochemistry",
"date": "1986",
"authors": "Bock SC, Skriver K, Nielsen E, Thogersen HC, Wiman B, Donaldson VH, Eddy RL, Marrinan J, Radziejewska E, Huber R, et al.",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "3756141",
"url": "https://glygen.org/publication/PubMed/3756141"
}
]
},
{
"title": "Gene for human factor X: a blood coagulation factor whose gene organization is essentially identical with that of factor IX and protein C.",
"journal": "Biochemistry",
"date": "1986",
"authors": "Leytus S P, Foster D C, Kurachi K, Davie E W",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "3768336",
"url": "https://glygen.org/publication/PubMed/3768336"
}
]
},
{
"title": "Five new F10 variants in hereditary factor x deficiency detected by high-throughput sequencing.",
"journal": "Haemophilia : the official journal of the World Federation of Hemophilia",
"date": "2023-11",
"authors": "Pastoret C\u00e9dric, Wahl Cl\u00e9mentine, Castet Sabine, Nedelec Fabienne, Pontis Adeline, Bayart Sophie, Fest Thierry, Guillet Beno\u00eet",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000495",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000495"
}
],
"reference": [
{
"type": "PubMed",
"id": "37842794",
"url": "https://glygen.org/publication/PubMed/37842794"
}
]
},
{
"title": "Inhibition of chymotrypsin by heparin cofactor II.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "1985",
"authors": "Church FC, Noyes CM, Griffith MJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140875",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875"
}
],
"reference": [
{
"type": "PubMed",
"id": "3863104",
"url": "https://glygen.org/publication/PubMed/3863104"
}
]
},
{
"title": "Amino acid sequence of the heavy chain of human alpha-factor XIIa (activated Hageman factor).",
"journal": "The Journal of biological chemistry",
"date": "1985",
"authors": "McMullen BA, Fujikawa K",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "3886654",
"url": "https://glygen.org/publication/PubMed/3886654"
}
]
},
{
"title": "Characterization of three abnormal factor IX variants (Bm Lake Elsinore, Long Beach, and Los Angeles) of hemophilia-B. Evidence for defects affecting the latent catalytic site.",
"journal": "The Journal of clinical investigation",
"date": "1985",
"authors": "Usharani P, Warn-Cramer BJ, Kasper CK, Bajaj SP",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9673202",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9673202"
}
],
"reference": [
{
"type": "PubMed",
"id": "3965513",
"url": "https://glygen.org/publication/PubMed/3965513"
}
]
},
{
"title": "The amino acid sequence of the light chain of human high-molecular-mass kininogen.",
"journal": "European journal of biochemistry",
"date": "1985",
"authors": "Lottspeich F, Kellermann J, Henschen A, Foertsch B, Muller-Esterl W",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "4054110",
"url": "https://glygen.org/publication/PubMed/4054110"
}
]
},
{
"title": "The inhibition of plasmin, plasma kallikrein, plasma permeability factor, and the C'1r subcomponent of the first component of complement by serum C'1 esterase inhibitor.",
"journal": "The Journal of experimental medicine",
"date": "1969",
"authors": "Ratnoff OD, Pensky J, Ogston D, Naff GB",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "4178758",
"url": "https://glygen.org/publication/PubMed/4178758"
}
]
},
{
"title": "Inhibition by C1INH of Hagemann factor fragment activation of coagulation, fibrinolysis, and kinin generation.",
"journal": "The Journal of clinical investigation",
"date": "1973",
"authors": "Schreiber AD, Kaplan AP, Austen KF",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "4703226",
"url": "https://glygen.org/publication/PubMed/4703226"
}
]
},
{
"title": "Human high molecular weight kininogen. Studies of structure-function relationships and of proteolysis of the molecule occurring during contact activation of plasma.",
"journal": "The Journal of biological chemistry",
"date": "1979",
"authors": "Kerbiriou DM, Griffin JH",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "500690",
"url": "https://glygen.org/publication/PubMed/500690"
}
]
},
{
"title": "Activation of human factor XI (plasma thromboplastin antecedent) by factor XIIa (activated Hageman factor).",
"journal": "Biochemistry",
"date": "1977",
"authors": "Kurachi K, Davie EW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "588558",
"url": "https://glygen.org/publication/PubMed/588558"
}
]
},
{
"title": "Primary structure of human alpha 2-macroglobulin. V. The complete structure.",
"journal": "The Journal of biological chemistry",
"date": "1984",
"authors": "Sottrup-Jensen L, Stepanik TM, Kristensen T, Wierzbicki DM, Jones CM, Lonblad PB, Magnusson S, Petersen TE",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "6203908",
"url": "https://glygen.org/publication/PubMed/6203908"
}
]
},
{
"title": "Mechanism of inhibition of activated protein C by protein C inhibitor.",
"journal": "J. Biochem.",
"date": "1984",
"authors": "Suzuki K, Nishioka J, Kusumoto H, Hashimoto S",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
},
{
"database": "Reactome",
"id": "R-HSA-140875",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875"
}
],
"reference": [
{
"type": "PubMed",
"id": "6323392",
"url": "https://glygen.org/publication/PubMed/6323392"
}
]
},
{
"title": "Binding of human blood-coagulation Factors IXa and X to phospholipid membranes.",
"journal": "The Biochemical journal",
"date": "1984",
"authors": "Mertens K, Cupers R, Van Wijngaarden A, Bertina RM",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "6334516",
"url": "https://glygen.org/publication/PubMed/6334516"
}
]
},
{
"title": "Structure of human factor VIII.",
"journal": "Nature",
"date": "1984",
"authors": "Vehar GA, Keyt B, Eaton D, Rodriguez H, O'Brien DP, Rotblat F, Oppermann H, Keck R, Wood WI, Harkins RN, Tuddenham EG, Lawn RM, Capon DJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "6438527",
"url": "https://glygen.org/publication/PubMed/6438527"
}
]
},
{
"title": "Characterization of a cDNA coding for human factor X.",
"journal": "Proc. Natl. Acad. Sci. U.S.A.",
"date": "1984",
"authors": "Leytus S P, Chung D W, Kisiel W, Kurachi K, Davie E W",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "6587384",
"url": "https://glygen.org/publication/PubMed/6587384"
}
]
},
{
"title": "Amino acid sequence of human beta-factor XIIa.",
"journal": "The Journal of biological chemistry",
"date": "1983",
"authors": "Fujikawa K, McMullen BA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "6604055",
"url": "https://glygen.org/publication/PubMed/6604055"
}
]
},
{
"title": "Complete amino acid sequence of the light chain of human blood coagulation factor X: evidence for identification of residue 63 as beta-hydroxyaspartic acid.",
"journal": "Biochemistry",
"date": "1983",
"authors": "McMullen BA, Fujikawa K, Kisiel W, Sasagawa T, Howald WN, Kwa EY, Weinstein B",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "6871167",
"url": "https://glygen.org/publication/PubMed/6871167"
}
]
},
{
"title": "Isolation and sequence of the vitamin K-dependent protein from human bone. Undercarboxylation of the first glutamic acid residue.",
"journal": "The Journal of biological chemistry",
"date": "1980",
"authors": "Poser JW, Esch FS, Ling NC, Price PA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-159740",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159740"
}
],
"reference": [
{
"type": "PubMed",
"id": "6967872",
"url": "https://glygen.org/publication/PubMed/6967872"
}
]
},
{
"title": "Binding of human factor VII and VIIa to monocytes.",
"journal": "The Journal of clinical investigation",
"date": "1982",
"authors": "Broze GJ Jr",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140834",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834"
}
],
"reference": [
{
"type": "PubMed",
"id": "6980899",
"url": "https://glygen.org/publication/PubMed/6980899"
}
]
},
{
"title": "Studies on synthetic peptides that bind to fibrinogen and prevent fibrin polymerization. Structural requirements, number of binding sites, and species differences.",
"journal": "Biochemistry",
"date": "1980",
"authors": "Laudano AP, Doolittle RF",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140875",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875"
}
],
"reference": [
{
"type": "PubMed",
"id": "7356959",
"url": "https://glygen.org/publication/PubMed/7356959"
}
]
},
{
"title": "Autoactivation of human Hageman factor. Demonstration utilizing a synthetic substrate.",
"journal": "The Journal of biological chemistry",
"date": "1980",
"authors": "Silverberg M, Dunn JT, Garen L, Kaplan AP",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "7391081",
"url": "https://glygen.org/publication/PubMed/7391081"
}
]
},
{
"title": "Effects of protein S and factor Xa on peptide bond cleavages during inactivation of factor Va and factor VaR506Q by activated protein C.",
"journal": "The Journal of biological chemistry",
"date": "1995",
"authors": "Rosing J, Hoekema L, Nicolaes GA, Thomassen MC, Hemker HC, Varadi K, Schwarz HP, Tans G",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140875",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875"
}
],
"reference": [
{
"type": "PubMed",
"id": "7499257",
"url": "https://glygen.org/publication/PubMed/7499257"
}
]
},
{
"title": "Identification of the oligosaccharide structures of human coagulation factor X activation peptide at each glycosylation site.",
"journal": "Glycoconjugate journal",
"date": "1995",
"authors": "Nakagawa H, Takahashi N, Fujikawa K, Kawamura Y, Iino M, Takeya H, Ogawa H, Suzuki K",
"evidence": [
{
"database": "UniCarbKB",
"id": "P00742",
"url": ""
},
{
"database": "GlyConnect",
"id": "102",
"url": "https://glyconnect.expasy.org/browser/proteins/102"
}
],
"reference": [
{
"type": "PubMed",
"id": "7620335",
"url": "https://glygen.org/publication/PubMed/7620335"
}
]
},
{
"title": "Molecular bases of CRM+ factor X deficiency: a frequent mutation (Ser334Pro) in the catalytic domain and a substitution (Glu102Lys) in the second EGF-like domain.",
"journal": "British journal of haematology",
"date": "1995",
"authors": "Marchetti G, Castaman G, Pinotti M, Lunghi B, Di Iasio MG, Ruggieri M, Rodeghiero F, Bernardi F",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "7669671",
"url": "https://glygen.org/publication/PubMed/7669671"
}
]
},
{
"title": "Expression of the blood-clotting factor-VIII cDNA is repressed by a transcriptional silencer located in its coding region.",
"journal": "Blood",
"date": "1995",
"authors": "Hoeben RC, Fallaux FJ, Cramer SJ, van den Wollenberg DJ, van Ormondt H, Briet E, van der Eb AJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "7727775",
"url": "https://glygen.org/publication/PubMed/7727775"
}
]
},
{
"title": "The affinity and stoichiometry of binding of human factor VIII to von Willebrand factor.",
"journal": "Blood",
"date": "1995",
"authors": "Vlot AJ, Koppelman SJ, van den Berg MH, Bouma BN, Sixma JJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "7756647",
"url": "https://glygen.org/publication/PubMed/7756647"
}
]
},
{
"title": "Factor IX Bm Kiryu: a Val-313-to-Asp substitution in the catalytic domain results in loss of function due to a conformational change of the surface loop: evidence obtained by chimaeric modelling.",
"journal": "British journal of haematology",
"date": "1994",
"authors": "Miyata T, Kuze K, Matsusue T, Komooka H, Kamiya K, Umeyama H, Matsui A, Kato H, Yoshioka A",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9673202",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9673202"
}
],
"reference": [
{
"type": "PubMed",
"id": "7803238",
"url": "https://glygen.org/publication/PubMed/7803238"
}
]
},
{
"title": "Factor XKetchikan: a variant molecule in which Gly replaces a Gla residue at position 14 in the light chain.",
"journal": "Human genetics",
"date": "1995",
"authors": "Kim DJ, Thompson AR, James HL",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "7860069",
"url": "https://glygen.org/publication/PubMed/7860069"
}
]
},
{
"title": "Factor IXa protects factor VIIIa from activated protein C. Factor IXa inhibits activated protein C-catalyzed cleavage of factor VIIIa at Arg562.",
"journal": "The Journal of biological chemistry",
"date": "1994",
"authors": "Regan LM, Lamphear BJ, Huggins CF, Walker FJ, Fay PJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140875",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875"
}
],
"reference": [
{
"type": "PubMed",
"id": "8144529",
"url": "https://glygen.org/publication/PubMed/8144529"
}
]
},
{
"title": "Biology of factor IX.",
"journal": "Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis",
"date": "1993",
"authors": "Kurachi K, Kurachi S, Furukawa M, Yao SN",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "8148489",
"url": "https://glygen.org/publication/PubMed/8148489"
}
]
},
{
"title": "Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular `heads` of C1q.",
"journal": "The Journal of experimental medicine",
"date": "1994",
"authors": "Ghebrehiwet B, Lim BL, Peerschke EI, Willis AC, Reid KB",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "8195709",
"url": "https://glygen.org/publication/PubMed/8195709"
}
]
},
{
"title": "Identification of O-linked oligosaccharide chains in the activation peptides of blood coagulation factor X. The role of the carbohydrate moieties in the activation of factor X.",
"journal": "European journal of biochemistry",
"date": "1993",
"authors": "Inoue K, Morita T",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742#ptm_processing"
},
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "8243461",
"url": "https://glygen.org/publication/PubMed/8243461"
}
]
},
{
"title": "The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade.",
"journal": "Molecular and cellular biology",
"date": "1993",
"authors": "Manfioletti G, Brancolini C, Avanzi G, Schneider C",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-159740",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159740"
}
],
"reference": [
{
"type": "PubMed",
"id": "8336730",
"url": "https://glygen.org/publication/PubMed/8336730"
}
]
},
{
"title": "Factor XII-independent activation of factor XI in plasma: effects of sulfatides on tissue factor-induced coagulation.",
"journal": "Blood",
"date": "1993",
"authors": "Gailani D, Broze GJ Jr",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "8338946",
"url": "https://glygen.org/publication/PubMed/8338946"
}
]
},
{
"title": "Sequencing and cloning of human prolylcarboxypeptidase (angiotensinase C). Similarity to both serine carboxypeptidase and prolylendopeptidase families.",
"journal": "The Journal of biological chemistry",
"date": "1993",
"authors": "Tan F, Morris PW, Skidgel RA, Erdos EG",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "8344943",
"url": "https://glygen.org/publication/PubMed/8344943"
}
]
},
{
"title": "Structure of human des(1-45) factor Xa at 2.2-A resolution.",
"journal": "J. Mol. Biol.",
"date": "1993",
"authors": "Padmanabhan K, Padmanabhan K P, Tulinsky A, Park C H, Bode W, Huber R, Blankenship D T, Cardin A D, Kisiel W",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "8355279",
"url": "https://glygen.org/publication/PubMed/8355279"
}
]
},
{
"title": "PACE/furin can process the vitamin K-dependent pro-factor IX precursor within the secretory pathway.",
"journal": "The Journal of biological chemistry",
"date": "1993",
"authors": "Wasley LC, Rehemtulla A, Bristol JA, Kaufman RJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-159782",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159782"
}
],
"reference": [
{
"type": "PubMed",
"id": "8473289",
"url": "https://glygen.org/publication/PubMed/8473289"
}
]
},
{
"title": "Functional consequences of the Ser334-->Pro mutation in a human factor X variant (factor XMarseille).",
"journal": "European journal of biochemistry",
"date": "1995",
"authors": "Bezeaud A, Miyata T, Helley D, Zeng YZ, Kato H, Aillaud MF, Juhan-Vague I, Guillin MC",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "8529633",
"url": "https://glygen.org/publication/PubMed/8529633"
}
]
},
{
"title": "Processive post-translational modification. Vitamin K-dependent carboxylation of a peptide substrate.",
"journal": "The Journal of biological chemistry",
"date": "1995",
"authors": "Morris DP, Stevens RD, Wright DJ, Stafford DW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-159740",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159740"
}
],
"reference": [
{
"type": "PubMed",
"id": "8530480",
"url": "https://glygen.org/publication/PubMed/8530480"
}
]
},
{
"title": "The tissue factor pathway: how it has become a `prima ballerina`.",
"journal": "Thrombosis and haemostasis",
"date": "1995",
"authors": "Rapaport SI, Rao LV",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140834",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834"
}
],
"reference": [
{
"type": "PubMed",
"id": "8578528",
"url": "https://glygen.org/publication/PubMed/8578528"
}
]
},
{
"title": "The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor.",
"journal": "Nature",
"date": "1996",
"authors": "Banner DW, D'Arcy A, Chene C, Winkler FK, Guha A, Konigsberg WH, Nemerson Y, Kirchhofer D",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140834",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834"
}
],
"reference": [
{
"type": "PubMed",
"id": "8598903",
"url": "https://glygen.org/publication/PubMed/8598903"
}
]
},
{
"title": "Activation of the factor VIIIa-factor IXa enzyme complex of blood coagulation by membranes containing phosphatidyl-L-serine.",
"journal": "The Journal of biological chemistry",
"date": "1996",
"authors": "Gilbert GE, Arena AA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "8626656",
"url": "https://glygen.org/publication/PubMed/8626656"
}
]
},
{
"title": "Kinetics of human factor VII activation.",
"journal": "Biochemistry",
"date": "1996",
"authors": "Butenas S, Mann KG",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140834",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834"
}
],
"reference": [
{
"type": "PubMed",
"id": "8639673",
"url": "https://glygen.org/publication/PubMed/8639673"
}
]
},
{
"title": "Identification of the zinc-dependent endothelial cell binding protein for high molecular weight kininogen and factor XII: identity with the receptor that binds to the globular `heads` of C1q (gC1q-R).",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "1996",
"authors": "Joseph K, Ghebrehiwet B, Peerschke EI, Reid KB, Kaplan AP",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "8710908",
"url": "https://glygen.org/publication/PubMed/8710908"
}
]
},
{
"title": "Activation and function of human Hageman factor. The role of high molecular weight kininogen and prekallikrein.",
"journal": "The Journal of clinical investigation",
"date": "1977",
"authors": "Meier HL, Pierce JV, Colman RW, Kaplan AP",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "874082",
"url": "https://glygen.org/publication/PubMed/874082"
}
]
},
{
"title": "Factor X Stockton: a mild bleeding diathesis associated with an active site mutation in factor X.",
"journal": "Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis",
"date": "1996",
"authors": "Messier TL, Wong CY, Bovill EG, Long GL, Church WR",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "8845463",
"url": "https://glygen.org/publication/PubMed/8845463"
}
]
},
{
"title": "Factor XSt. Louis II. Identification of a glycine substitution at residue 7 and characterization of the recombinant protein.",
"journal": "The Journal of biological chemistry",
"date": "1996",
"authors": "Rudolph AE, Mullane MP, Porche-Sorbet R, Tsuda S, Miletich JP",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "8910490",
"url": "https://glygen.org/publication/PubMed/8910490"
}
]
},
{
"title": "Activation of Mac-1 (CD11b/CD18)-bound factor X by released cathepsin G defines an alternative pathway of leucocyte initiation of coagulation.",
"journal": "The Biochemical journal",
"date": "1996",
"authors": "Plescia J, Altieri DC",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "8920993",
"url": "https://glygen.org/publication/PubMed/8920993"
}
]
},
{
"title": "Human blood coagulation factor XI. Purification, properties, and mechanism of activation by activated factor XII.",
"journal": "The Journal of biological chemistry",
"date": "1977",
"authors": "Bouma BN, Griffin JH",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "893417",
"url": "https://glygen.org/publication/PubMed/893417"
}
]
},
{
"title": "Identification of functional endothelial protein C receptor in human plasma.",
"journal": "The Journal of clinical investigation",
"date": "1997",
"authors": "Kurosawa S, Stearns-Kurosawa DJ, Hidari N, Esmon CT",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140875",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875"
}
],
"reference": [
{
"type": "PubMed",
"id": "9218519",
"url": "https://glygen.org/publication/PubMed/9218519"
}
]
},
{
"title": "High molecular weight kininogen peptides inhibit the formation of kallikrein on endothelial cell surfaces and subsequent urokinase-dependent plasmin formation.",
"journal": "Blood",
"date": "1997",
"authors": "Lin Y, Harris RB, Yan W, McCrae KR, Zhang H, Colman RW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "9226169",
"url": "https://glygen.org/publication/PubMed/9226169"
}
]
},
{
"title": "High molecular weight kininogen regulates prekallikrein assembly and activation on endothelial cells: a novel mechanism for contact activation.",
"journal": "Blood",
"date": "1998",
"authors": "Motta G, Rojkjaer R, Hasan AA, Cines DB, Schmaier AH",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "9427705",
"url": "https://glygen.org/publication/PubMed/9427705"
}
]
},
{
"title": "The molecular basis for cross-reacting material-positive hemophilia A due to missense mutations within the A2-domain of factor VIII.",
"journal": "Blood",
"date": "1998",
"authors": "Amano K, Sarkar R, Pemberton S, Kemball-Cook G, Kazazian HH Jr, Kaufman RJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9672396",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9672396"
}
],
"reference": [
{
"type": "PubMed",
"id": "9427707",
"url": "https://glygen.org/publication/PubMed/9427707"
}
]
},
{
"title": "Effects of melagatran, a new low-molecular-weight thrombin inhibitor, on thrombin and fibrinolytic enzymes.",
"journal": "Thrombosis and haemostasis",
"date": "1998",
"authors": "Gustafsson D, Antonsson T, Bylund R, Eriksson U, Gyzander E, Nilsson I, Elg M, Mattsson C, Deinum J, Pehrsson S, Karlsson O, Nilsson A, Sorensen H",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "9459334",
"url": "https://glygen.org/publication/PubMed/9459334"
}
]
},
{
"title": "Novastan (brand of argatroban): a small-molecule, direct thrombin inhibitor.",
"journal": "Seminars in thrombosis and hemostasis",
"date": "1997",
"authors": "Hursting MJ, Alford KL, Becker JC, Brooks RL, Joffrion JL, Knappenberger GD, Kogan PW, Kogan TP, McKinney AA, Schwarz RP Jr",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "9469622",
"url": "https://glygen.org/publication/PubMed/9469622"
}
]
},
{
"title": "Biosynthesis, assembly and secretion of coagulation factor VIII.",
"journal": "Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis",
"date": "1997",
"authors": "Kaufman RJ, Pipe SW, Tagliavacca L, Swaroop M, Moussalli M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "9607108",
"url": "https://glygen.org/publication/PubMed/9607108"
}
]
},
{
"title": "Structural basis for chemical inhibition of human blood coagulation factor Xa.",
"journal": "Proc. Natl. Acad. Sci. U.S.A.",
"date": "1998",
"authors": "Kamata K, Kawamoto H, Honma T, Iwama T, Kim S H",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"reference": [
{
"type": "PubMed",
"id": "9618463",
"url": "https://glygen.org/publication/PubMed/9618463"
}
]
},
{
"title": "Activation of factor VIII by thrombin increases its affinity for binding to synthetic phospholipid membranes and activated platelets.",
"journal": "The Journal of biological chemistry",
"date": "1998",
"authors": "Saenko EL, Scandella D, Yakhyaev AV, Greco NJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "9774404",
"url": "https://glygen.org/publication/PubMed/9774404"
}
]
},
{
"title": "The life cycle of coagulation factor VIII in view of its structure and function.",
"journal": "Blood",
"date": "1998",
"authors": "Lenting PJ, van Mourik JA, Mertens K",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "9834200",
"url": "https://glygen.org/publication/PubMed/9834200"
}
]
},
{
"title": "Thrombin activates factor XI on activated platelets in the absence of factor XII.",
"journal": "Arteriosclerosis, thrombosis, and vascular biology",
"date": "1999",
"authors": "Oliver JA, Monroe DM, Roberts HR, Hoffman M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-140837",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837"
}
],
"reference": [
{
"type": "PubMed",
"id": "9888880",
"url": "https://glygen.org/publication/PubMed/9888880"
}
]
}
],
"pathway": [
{
"id": "hsa:2159",
"name": "",
"url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:2159",
"resource": "KEGG Pathway"
},
{
"id": "R-HSA-140834",
"name": "Extrinsic Pathway of Fibrin Clot Formation",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140834",
"resource": "Reactome",
"description": "Extrinsic Pathway of Fibrin Clot Formation"
},
{
"id": "R-HSA-140837",
"name": "Intrinsic Pathway of Fibrin Clot Formation",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140837",
"resource": "Reactome",
"description": "Intrinsic Pathway of Fibrin Clot Formation"
},
{
"id": "R-HSA-140875",
"name": "Common Pathway of Fibrin Clot Formation",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875",
"resource": "Reactome",
"description": "Common Pathway of Fibrin Clot Formation"
},
{
"id": "R-HSA-159740",
"name": "Gamma-carboxylation of protein precursors",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159740",
"resource": "Reactome",
"description": "Gamma-carboxylation of protein precursors"
},
{
"id": "R-HSA-159763",
"name": "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159763",
"resource": "Reactome",
"description": "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus"
},
{
"id": "R-HSA-159782",
"name": "Removal of aminoterminal propeptides from gamma-carboxylated proteins",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159782",
"resource": "Reactome",
"description": "Removal of aminoterminal propeptides from gamma-carboxylated proteins"
},
{
"id": "R-HSA-9672383",
"name": "Defective factor IX causes thrombophilia",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9672383",
"resource": "Reactome",
"description": "Defective factor IX causes thrombophilia"
},
{
"id": "R-HSA-9672396",
"name": "Defective cofactor function of FVIIIa variant",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9672396",
"resource": "Reactome",
"description": "Defective cofactor function of FVIIIa variant"
},
{
"id": "R-HSA-9673202",
"name": "Defective F9 variant does not activate FX",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9673202",
"resource": "Reactome",
"description": "Defective F9 variant does not activate FX"
}
],
"orthologs": [
{
"uniprot_canonical_ac": "O88947-1",
"protein_name": "Coagulation factor X",
"gene_name": "F10",
"tax_id": 10090,
"organism": "Mus musculus",
"sequence": {
"sequence": "MGSPVQLSLLCVVLASLLLPGKGVFINRERANNVLARTRRANSFFEEFKKGNLERECMEEICSYEEVREIFEDDEKTKEYWTKYKDGDQCESSPCQNQGACRDGIGGYTCTCSEGFEGKNCELFVRKLCRLDNGDCDQFCREEQNSVVCSCASGYFLGNDGKSCISTAPFPCGKITTGRRKRSVALNTSDSELDLEDALLDEDFLSPTENPIELLNLNETQPERSSDDLVRIVGGRECKDGECPWQALLINEDNEGFCGGTILNEFYILTAAHCLHQARRFKVRVGDRNTEKEEGNEMVHEVDVVIKHNKFQRDTYDYDIAVLRLKTPITFRMNVAPACLPQKDWAESTLMTQKTGIVSGFGRTHEKGRQSNILKMLEVPYVDRNTCKLSTSFSITQNMFCAGYEAKLEDACQGDSGGPHVTRFKNTYYVTGIVSWGEGCARKGKYGIYTKVTTFLKWIDRSMKARVGPTAETPRTAGPPN",
"length": 481
},
"evidence": [
{
"id": "45917658",
"url": "http://www.informatics.jax.org/homology/45917658",
"database": "MGI"
}
],
"common_name": "Mouse"
},
{
"uniprot_canonical_ac": "Q63207-1",
"protein_name": "Coagulation factor X",
"gene_name": "F10",
"tax_id": 10116,
"organism": "Rattus norvegicus",
"sequence": {
"sequence": "MESPVRLSLLYVVLASLLLPGRSVFINRERANNVLQRIRRANSFFEEIKKGNLERECVEEICSFEEAREVFEDNEKTTEFWNKYEDGDQCESSPCQNQGECRDGLGSYTCTCTEGFEGKNCELFVRKLCSLDNGDCDQFCREEQNSVVCSCAKGYFLGNDGKSCLSTAPFPCGKTNKGRAKRSVALNTSNSEPDPEDLMPDADILYPTESPSELLNLNKTEPEANSDDVIRIVGGQECKRGECPWQALLFSDEETDGFCGGTILNEFYILTAAHCLHQAKRFKVRVGDLNTEQEDGGEMVHEVDMIIKHNKFQRDTYDFDIAMLRLKTPITFRENVAPACLPQKDWAEATLMTQKTGIVSGFGRTHEKGRQSKVLKMMEVPYVDRNTCRLSTSFSITQNMFCAGYDAKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKARVGPTSETPRLTHPPY",
"length": 482
},
"evidence": [
{
"id": "45917658",
"url": "http://www.informatics.jax.org/homology/45917658",
"database": "MGI"
}
],
"common_name": "Rat"
}
],
"go_annotation": {
"categories": [
{
"name": "Molecular Function",
"total": 3,
"go_terms": [
{
"name": "serine-type endopeptidase activity",
"id": "GO:0004252",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"pmid": ""
},
{
"name": "calcium ion binding",
"id": "GO:0005509",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"pmid": ""
},
{
"name": "phospholipid binding",
"id": "GO:0005543",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005543",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"pmid": ""
}
]
},
{
"name": "Cellular Component",
"total": 7,
"go_terms": [
{
"name": "extracellular region",
"id": "GO:0005576",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"pmid": ""
},
{
"name": "endoplasmic reticulum lumen",
"id": "GO:0005788",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"pmid": ""
},
{
"name": "Golgi lumen",
"id": "GO:0005796",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005796",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"pmid": ""
},
{
"name": "extracellular space",
"id": "GO:0005615",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"pmid": ""
},
{
"name": "plasma membrane",
"id": "GO:0005886",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"pmid": ""
},
{
"name": "external side of plasma membrane",
"id": "GO:0009897",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"pmid": ""
},
{
"name": "endoplasmic reticulum",
"id": "GO:0005783",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"pmid": ""
}
]
},
{
"name": "Biological Process",
"total": 4,
"go_terms": [
{
"name": "proteolysis",
"id": "GO:0006508",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"pmid": ""
},
{
"name": "blood coagulation",
"id": "GO:0007596",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007596",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"pmid": ""
},
{
"name": "positive regulation of cell migration",
"id": "GO:0030335",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"pmid": ""
},
{
"name": "positive regulation of TOR signaling",
"id": "GO:0032008",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032008",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
}
],
"pmid": ""
}
]
}
]
},
"pro_annotation": [
{
"name": "coagulation factor X N-glycosylated 1 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-221 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G18938DW. Example: UniProtKB:P00742-1, Asn-221, MOD:00160~GNO:G18938DW. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051163",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051163"
}
]
},
{
"name": "coagulation factor X N-glycosylated 2 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-221 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G24501HF. Example: UniProtKB:P00742-1, Asn-221, MOD:00160~GNO:G24501HF. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051164",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051164"
}
]
},
{
"name": "coagulation factor X N-glycosylated 3 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-221 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G29857RC. Example: UniProtKB:P00742-1, Asn-221, MOD:00160~GNO:G29857RC. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051165",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051165"
}
]
},
{
"name": "coagulation factor X N-glycosylated 4 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-221 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G32854GF. Example: UniProtKB:P00742-1, Asn-221, MOD:00160~GNO:G32854GF. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051166",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051166"
}
]
},
{
"name": "coagulation factor X N-glycosylated 5 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-221 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G36191CD. Example: UniProtKB:P00742-1, Asn-221, MOD:00160~GNO:G36191CD. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051167",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051167"
}
]
},
{
"name": "coagulation factor X N-glycosylated 6 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-221 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G45359RY. Example: UniProtKB:P00742-1, Asn-221, MOD:00160~GNO:G45359RY. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051168",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051168"
}
]
},
{
"name": "coagulation factor X N-glycosylated 7 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-221 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G46568MX. Example: UniProtKB:P00742-1, Asn-221, MOD:00160~GNO:G46568MX. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051169",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051169"
}
]
},
{
"name": "coagulation factor X N-glycosylated 8 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-221 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G49478NM. Example: UniProtKB:P00742-1, Asn-221, MOD:00160~GNO:G49478NM. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051170",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051170"
}
]
},
{
"name": "coagulation factor X N-glycosylated 9 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-221 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G68866GS. Example: UniProtKB:P00742-1, Asn-221, MOD:00160~GNO:G68866GS. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051171",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051171"
}
]
},
{
"name": "coagulation factor X N-glycosylated 10 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-221 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G73073LQ. Example: UniProtKB:P00742-1, Asn-221, MOD:00160~GNO:G73073LQ. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051172",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051172"
}
]
},
{
"name": "coagulation factor X N-glycosylated 11 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-221 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G75850OP. Example: UniProtKB:P00742-1, Asn-221, MOD:00160~GNO:G75850OP. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051173",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051173"
}
]
},
{
"name": "coagulation factor X N-glycosylated 12 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-221 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G78059CC. Example: UniProtKB:P00742-1, Asn-221, MOD:00160~GNO:G78059CC. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051174",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051174"
}
]
},
{
"name": "coagulation factor X N-glycosylated 13 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-221 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G79809MM. Example: UniProtKB:P00742-1, Asn-221, MOD:00160~GNO:G79809MM. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051175",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051175"
}
]
},
{
"name": "coagulation factor X N-glycosylated 14 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-221 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G85678WN. Example: UniProtKB:P00742-1, Asn-221, MOD:00160~GNO:G85678WN. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051176",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051176"
}
]
},
{
"name": "coagulation factor X N-glycosylated 15 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-221 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G88068QT. Example: UniProtKB:P00742-1, Asn-221, MOD:00160~GNO:G88068QT. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051177",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051177"
}
]
},
{
"name": "coagulation factor X N-glycosylated 16 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-221 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G91365ZQ. Example: UniProtKB:P00742-1, Asn-221, MOD:00160~GNO:G91365ZQ. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051178",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051178"
}
]
},
{
"name": "coagulation factor X N-glycosylated 17 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-231 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G18938DW. Example: UniProtKB:P00742-1, Asn-231, MOD:00160~GNO:G18938DW. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051179",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051179"
}
]
},
{
"name": "coagulation factor X N-glycosylated 18 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-231 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G29857RC. Example: UniProtKB:P00742-1, Asn-231, MOD:00160~GNO:G29857RC. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051180",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051180"
}
]
},
{
"name": "coagulation factor X N-glycosylated 19 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-231 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G36191CD. Example: UniProtKB:P00742-1, Asn-231, MOD:00160~GNO:G36191CD. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051181",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051181"
}
]
},
{
"name": "coagulation factor X N-glycosylated 20 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-231 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G45359RY. Example: UniProtKB:P00742-1, Asn-231, MOD:00160~GNO:G45359RY. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051182",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051182"
}
]
},
{
"name": "coagulation factor X N-glycosylated 21 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-231 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G46568MX. Example: UniProtKB:P00742-1, Asn-231, MOD:00160~GNO:G46568MX. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051183",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051183"
}
]
},
{
"name": "coagulation factor X N-glycosylated 22 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-231 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G49478NM. Example: UniProtKB:P00742-1, Asn-231, MOD:00160~GNO:G49478NM. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051184",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051184"
}
]
},
{
"name": "coagulation factor X N-glycosylated 23 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-231 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G73073LQ. Example: UniProtKB:P00742-1, Asn-231, MOD:00160~GNO:G73073LQ. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051185",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051185"
}
]
},
{
"name": "coagulation factor X N-glycosylated 24 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-231 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G75850OP. Example: UniProtKB:P00742-1, Asn-231, MOD:00160~GNO:G75850OP. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051186",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051186"
}
]
},
{
"name": "coagulation factor X N-glycosylated 25 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-231 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G78059CC. Example: UniProtKB:P00742-1, Asn-231, MOD:00160~GNO:G78059CC. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051187",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051187"
}
]
},
{
"name": "coagulation factor X N-glycosylated 26 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-231 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G79809MM. Example: UniProtKB:P00742-1, Asn-231, MOD:00160~GNO:G79809MM. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051188",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051188"
}
]
},
{
"name": "coagulation factor X N-glycosylated 27 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-231 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G85678WN. Example: UniProtKB:P00742-1, Asn-231, MOD:00160~GNO:G85678WN. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051189",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051189"
}
]
},
{
"name": "coagulation factor X N-glycosylated 28 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-231 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G88068QT. Example: UniProtKB:P00742-1, Asn-231, MOD:00160~GNO:G88068QT. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051190",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051190"
}
]
},
{
"name": "coagulation factor X N-glycosylated 29 (human)",
"definition": "A coagulation factor X (human) that has been N-glycosylated at the residue equivalent to Asn-231 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan structure is represented by GlyTouCan:G91365ZQ. Example: UniProtKB:P00742-1, Asn-231, MOD:00160~GNO:G91365ZQ. [PRO:DNx, PMID:7620335]",
"evidence": [
{
"id": "PR:000051191",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051191"
}
]
},
{
"name": "coagulation factor X O-glycosylated 1 (human)",
"definition": "A coagulation factor X (human) that has been O-glycosylated at the residue equivalent to Ser-189 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P00742-1, Ser-189, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:22171320]",
"evidence": [
{
"id": "PR:000051192",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051192"
}
]
},
{
"name": "coagulation factor X O-glycosylated 2 (human)",
"definition": "A coagulation factor X (human) that has been O-glycosylated at the residue equivalent to Ser-190 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P00742-1, Ser-190, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:22171320]",
"evidence": [
{
"id": "PR:000051193",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051193"
}
]
},
{
"name": "coagulation factor X O-glycosylated 3 (human)",
"definition": "A coagulation factor X (human) that has been O-glycosylated at the residue equivalent to Ser-197 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P00742-1, Ser-197, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:22171320]",
"evidence": [
{
"id": "PR:000051194",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051194"
}
]
},
{
"name": "coagulation factor X O-glycosylated 4 (human)",
"definition": "A coagulation factor X (human) that has been O-glycosylated at the residue equivalent to Ser-476 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P00742-1, Ser-476, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:22171320]",
"evidence": [
{
"id": "PR:000051195",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051195"
}
]
},
{
"name": "coagulation factor X O-glycosylated 5 (human)",
"definition": "A coagulation factor X (human) that has been O-glycosylated at the residue equivalent to Ser-484 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P00742-1, Ser-484, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:22171320]",
"evidence": [
{
"id": "PR:000051196",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051196"
}
]
},
{
"name": "coagulation factor X O-glycosylated 6 (human)",
"definition": "A coagulation factor X (human) that has been O-glycosylated at the residue equivalent to Ser-485 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P00742-1, Ser-485, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:22171320]",
"evidence": [
{
"id": "PR:000051197",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051197"
}
]
},
{
"name": "coagulation factor X O-glycosylated 7 (human)",
"definition": "A coagulation factor X (human) that has been O-glycosylated at the residue equivalent to Thr-188 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P00742-1, Thr-188, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:22171320]",
"evidence": [
{
"id": "PR:000051198",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051198"
}
]
},
{
"name": "coagulation factor X O-glycosylated 8 (human)",
"definition": "A coagulation factor X (human) that has been O-glycosylated at the residue equivalent to Thr-188 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P00742-1, Thr-188, MOD:00005~GNO:G53434XO. [PRO:DNx, PMID:30459171]",
"evidence": [
{
"id": "PR:000051199",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051199"
}
]
},
{
"name": "coagulation factor X O-glycosylated 9 (human)",
"definition": "A coagulation factor X (human) that has been O-glycosylated at the residue equivalent to Thr-199 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P00742-1, Thr-199, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:22171320]",
"evidence": [
{
"id": "PR:000051200",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051200"
}
]
},
{
"name": "coagulation factor X O-glycosylated 10 (human)",
"definition": "A coagulation factor X (human) that has been O-glycosylated at the residue equivalent to Thr-483 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P00742-1, Thr-483, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:22171320]",
"evidence": [
{
"id": "PR:000051201",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051201"
}
]
},
{
"name": "coagulation factor X O-glycosylated 11 (human)",
"definition": "A coagulation factor X (human) that has been O-glycosylated at the residue equivalent to Tyr-203 of the amino acid sequence represented by UniProtKB:P00742-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P00742-1, Tyr-203, MOD:01927~GNO:G43417UB. [PRO:DNx, PMID:22171320]",
"evidence": [
{
"id": "PR:000051202",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051202"
}
]
}
],
"site_annotation": [
{
"start_pos": 221,
"end_pos": 223,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 231,
"end_pos": 233,
"annotation": "n_glycosylation_sequon"
}
],
"ptm_annotation": [
{
"annotation": "N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
},
{
"database": "PubMed",
"id": "8243461",
"url": "https://glygen.org/publication/PubMed/8243461"
},
{
"database": "PubMed",
"id": "22171320",
"url": "https://glygen.org/publication/PubMed/22171320"
}
]
},
{
"annotation": "Proteolytically cleaved and activated by cathepsin CTSG (PubMed:8920993). The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway) (By similarity).",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
},
{
"database": "PubMed",
"id": "8920993",
"url": "https://glygen.org/publication/PubMed/8920993"
}
]
},
{
"annotation": "The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.",
"evidence": [
{
"database": "UniProtKB",
"id": "P00742",
"url": "https://www.uniprot.org/uniprot/P00742"
},
{
"database": "PubMed",
"id": "6871167",
"url": "https://glygen.org/publication/PubMed/6871167"
}
]
}
],
"interactions": [],
"reactions": [
{
"id": "R-HSA-140664",
"name": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)",
"equation": "",
"summary": "The membrane-bound Va:Xa (prothrombinase) complex rapidly activates large amounts of thrombin. Factor Xa (aka Factor X heavy chain), a cleavage product of coagulation factor X (F10), is a vitamin K-dependent glycoprotein able to convert prothrombin to thrombin during the blood clotting process (Mann et al. 1988, Orfeo et al. 2004). Factor Xa is a target for direct oral anticoagulant (DOAC) drugs that are direct factor Xa inhibitors (the so-called 'xabans') and used in the treatment and prevention of thromboembolic disorders (Galanis et al. 2014). Rivaroxaban (brand name Xarelto) binds to and inhibits both free factor Xa and factor Xa bound in the prothrombinase complex (Va:Xa) (Roehrig et al. 2005). Rivaroxaban was the first medically approved drug of this class (Abrams & Emerson 2009, Misselwitz et al. 2011). In patients with non-valvular atrial fibrillation, 'xabans' appears to be as effective as warfarin in preventing nonhemorrhagic strokes and embolic events (Patel et al. 2011, Gomez-Outes et al. 2013). The most serious side-effect of rivaroxaban is GI bleeding, and with there being no antidote for rivaroxaban, bleeding events can be difficult to manage (Siegal et al. 2014). Other 'xabans' such as apixaban (Bhanwra & Ahluwalia 2014), edoxaban (Minor et al. 2015), eribaxaban (Bondarenko et al. 2013) and betrixaban (Zhang et al. 2009) share a similar mechanism of action to rivaroxaban (Nutescu et al. 2016). Unlike warfarin, the 'xabans' exhibit a predictable dose response and do not require routine coagulation monitoring.",
"cellular_location": "extracellular region, plasma membrane",
"input_participant_list": [
"R-HSA-140674"
],
"output_participant_list": [
"R-HSA-156786",
"R-HSA-140786"
],
"enzyme_list": [
"P00742-1",
"P00734-1"
],
"evidence": [
{
"id": "R-HSA-140664",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140664"
}
]
},
{
"id": "R-HSA-140686",
"name": "factor Va + factor Xa -> Va:Xa complex (prothrombinase)",
"equation": "",
"summary": "Factors Va and Xa associate on a membrane surface to form a complex in which the activity of factor Xa on prothrombin is greatly increased (Mann et al. 1988). The presence of negatively charged phospholipid in the membrane greatly facilitates this process, a feature that may contribute to its localization, as such phospholipids are normally on the cytosolic face of the plasma membrane (Devaux 1992), but could be exposed to the extracellular space following platelet activation or mechanical injury to endothelial cells.",
"cellular_location": "extracellular region, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00742-1"
],
"evidence": [
{
"id": "R-HSA-140686",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140686"
}
]
},
{
"id": "R-HSA-140700",
"name": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)",
"equation": "",
"summary": "Membrane-bound factor Xa catalyzes the activation of small amounts of thrombin. The amino terminal portion of prothrombin is released as an activation peptide, which can be cleaved further by activated thrombin. Neither the full-length activation peptide nor its cleavage products have known functions.
Factor Xa (aka Factor X heavy chain), a cleavage product of coagulation factor X (F10), is a vitamin K-dependent glycoprotein able to convert prothrombin to thrombin during the blood clotting process. Factor Xa is a target for direct oral anticoagulant (DOAC) drugs that are direct factor Xa inhibitors (the so-called 'xabans') and used in the treatment and prevention of thromboembolic disorders (Galanis et al. 2014). Rivaroxaban (brand name Xarelto) binds to and inhibits both free factor Xa and factor Xa bound in the prothrombinase complex (Va:Xa) (Roehrig et al. 2005). Rivaroxaban was the first medically approved drug of this class (Abrams & Emerson 2009, Misselwitz et al. 2011). In patients with non-valvular atrial fibrillation, 'xabans' appears to be as effective as warfarin in preventing nonhemorrhagic strokes and embolic events (Patel et al. 2011, Gomez-Outes et al. 2013). The most serious side-effect of rivaroxaban is GI bleeding, and with there being no antidote for rivaroxaban, bleeding events can be difficult to manage (Siegal et al. 2014). Other 'xabans' such as apixaban (Bhanwra & Ahluwalia 2014), edoxaban (Minor et al. 2015), eribaxaban (Bondarenko et al. 2013) and betrixaban (Zhang et al. 2009) share a similar mechanism of action to rivaroxaban (Nutescu et al. 2016). Unlike warfarin, the 'xabans' exhibit a predictable dose response and do not require routine coagulation monitoring.",
"cellular_location": "extracellular region, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00742-1",
"P00734-1"
],
"evidence": [
{
"id": "R-HSA-140700",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140700"
}
]
},
{
"id": "R-HSA-140736",
"name": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst)",
"equation": "",
"summary": "Factor VIIa, bound to tissue factor at the endothelial cell surface (the \\extrinsic tenase complex\\), catalyzes the formation of activated factor X with high efficiency. The amino terminal part of the heavy chain of factor X, the factor X activation peptide, is released. (This peptide has no known function.)",
"cellular_location": "extracellular region, plasma membrane",
"input_participant_list": [
"R-HSA-140739"
],
"output_participant_list": [
"R-HSA-140689",
"R-HSA-140785"
],
"enzyme_list": [
"P00742-1",
"P08709-1"
],
"evidence": [
{
"id": "R-HSA-140736",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140736"
}
]
},
{
"id": "R-HSA-140769",
"name": "factor VII -> factor VIIa",
"equation": "",
"summary": "Factor Xa catalyzes the activation of factor VII from plasma.",
"cellular_location": "extracellular region",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00742-1",
"P08709-1"
],
"evidence": [
{
"id": "R-HSA-140769",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140769"
}
]
},
{
"id": "R-HSA-140777",
"name": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)",
"equation": "",
"summary": "Factor VII, bound to tissue factor at the endothelial cell surface, catalyzes the activation of factor X from plasma with moderate efficiency. The amino terminal part of the heavy chain of factor X, the factor X activation peptide, is released. (This peptide has no known function.)",
"cellular_location": "extracellular region, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00742-1",
"P08709-1"
],
"evidence": [
{
"id": "R-HSA-140777",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140777"
}
]
},
{
"id": "R-HSA-140825",
"name": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa",
"equation": "",
"summary": "TFPI binds to the factor VIIa:TF complex and to factor Xa at the endothelial surface, forming a stable heterotetrameric complex in which factor VIIa is catalytically inactive.",
"cellular_location": "extracellular region, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00742-1",
"P08709-1"
],
"evidence": [
{
"id": "R-HSA-140825",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140825"
}
]
},
{
"id": "R-HSA-158164",
"name": "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)",
"equation": "",
"summary": "Factor IXa, in a complex with factor VIIIa on the surfaces of activated platelets (the \\intrinsic tenase complex\\), catalyzes the formation of activated factor X with high efficiency. The amino terminal part of the heavy chain of factor X, the factor X activation peptide, is released. (This peptide has no known function.)",
"cellular_location": "extracellular region, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00742-1",
"P00740-1"
],
"evidence": [
{
"id": "R-HSA-158164",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-158164"
}
]
},
{
"id": "R-HSA-159733",
"name": "Furin cleaves pro-factor X to factor X",
"equation": "",
"summary": "Furin, associated with the Golgi membrane, cleaves pro-factor X to form mature, gamma-carboxylated factor X (Wasley et al. 1993).",
"cellular_location": "Golgi lumen, Golgi membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00742-1",
"P09958-1"
],
"evidence": [
{
"id": "R-HSA-159733",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159733"
}
]
},
{
"id": "R-HSA-159757",
"name": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus",
"equation": "",
"summary": "Gamma-carboxylated pro-factor X is transported from the endoplasmic reticulum to the Golgi apparatus (Kirchhausen 2000).",
"cellular_location": "COPII-coated ER to Golgi transport vesicle, Golgi lumen, endoplasmic reticulum lumen",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00742-1"
],
"evidence": [
{
"id": "R-HSA-159757",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159757"
}
]
},
{
"id": "R-HSA-159819",
"name": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain)",
"equation": "",
"summary": "GGCX (gamma glutamyl carboxylase) in the endoplasmic reticulum gamma-carboxylates eleven glutamate residues on 3D-F10(32-179) (pro-factor X light chain). MK4 (vitamin K hydroquinone) is oxidized to MK4 epoxide in the process (Berkner 2000; Furie et al. 1999; Stenina et al. 2001; Morris et al. 1995).",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00742-1",
"P38435-1"
],
"evidence": [
{
"id": "R-HSA-159819",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-159819"
}
]
},
{
"id": "R-HSA-9015111",
"name": "Factor Xa inhibitors binds Xa",
"equation": "",
"summary": "Factor Xa (aka Factor X heavy chain), a cleavage product of coagulation factor X (F10), is a vitamin K-dependent glycoprotein able to convert prothrombin to thrombin during the blood clotting process. Factor Xa is a target for direct oral anticoagulant (DOAC) drugs that are direct factor Xa inhibitors (the so-called 'xabans') which are used in the treatment and prevention of thromboembolic disorders (Galanis et al. 2014). Rivaroxaban (brand name Xarelto) was the first medically approved drug of this class (Abrams & Emerson 2009, Misselwitz et al. 2011). Rivaroxaban binds to and inhibits both free factor Xa and factor Xa bound in the prothrombinase complex (Roehrig et al. 2005). Other 'xabans' such as apixaban (Bhanwra & Ahluwalia 2014), edoxaban (Minor et al. 2015), eribaxaban (Bondarenko et al. 2013) and betrixaban (Zhang et al. 2009) share a similar mechanism of action to rivaroxaban (Nutescu et al. 2016).",
"cellular_location": "extracellular region, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00742-1"
],
"evidence": [
{
"id": "R-HSA-9015111",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9015111"
}
]
},
{
"id": "R-HSA-9015122",
"name": "Factor Xa inhibitors bind Va:Xa",
"equation": "",
"summary": "Factor Xa (aka Factor X heavy chain), a cleavage product of coagulation factor X (F10), is a vitamin K-dependent glycoprotein able to convert prothrombin to thrombin during the blood clotting process. Factor Xa is a target for direct oral anticoagulant (DOAC) drugs that are direct factor Xa inhibitors (the so-called 'xabans') which are used in the treatment and prevention of thromboembolic disorders (Galanis et al. 2014, Nutescu et al. 2016). Rivaroxaban (brand name Xarelto) binds to and inhibits both free factor Xa and factor Xa bound in the prothrombinase complex (Va:Xa) (Roehrig et al. 2005). Rivaroxaban was the first medically approved drug of this class (Abrams & Emerson 2009, Misselwitz et al. 2011). Other 'xabans' such as apixaban (Bhanwra & Ahluwalia 2014), edoxaban (Minor et al. 2015), eribaxaban (Bondarenko et al. 2013) and betrixaban (Zhang et al. 2009) share a similar mechanism of action to rivaroxaban (Nutescu et al. 2016).",
"cellular_location": "extracellular region, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00742-1"
],
"evidence": [
{
"id": "R-HSA-9015122",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9015122"
}
]
},
{
"id": "R-HSA-9668253",
"name": "Hyperactivation of factor X by FVIIIa:FIXa R384L",
"equation": "",
"summary": "In healthy individuals factor IXa (FIXa), in a complex with factor VIIIa on the surfaces of activated platelets, catalyzes the formation of activated factor X with high efficiency. A substitution of leucine for arginine at residue 384 in FIX (FIX R384L, also know as FIX Padua) is a gain-of-function mutation that resulted in elevated FIX clotting activity in a patient with venous thrombosis (Simioni P et al. 2009). The level of the FIX R384L protein in the patient plasma was normal, but the clotting activity from the proband was approximately eight times the normal level. In vitro, recombinant FIX R384L had a specific activity that was 5 to 10 times as high as that in the recombinant wild-type FIX (Simioni P et al. 2009). In addition, FIXa R384L showed a resistance to inhibition by protein S (PROS1), a plasma protein that directly binds and inhibits FIXa to modulate a clotting rate in vitro and in vivo (Plautz WE et al. 2018a,b). The ability of the FIX Padua variant to increase the clotting activity prompted researchers to try to produce chimeric FIX Padua concentrates for potential use in the treatment of patients with hemophilia B (Lozier JN 2012; Monahan PE et al. 2015; Spronck EA et al. 2019). Epidemiological studies in groups of patients with venous thrombosis failed to discover other cases with this FIX abnormality, indicating that the defect is rare (Koenderman JS et al. 2011; de Moraes Mazetto B et al. 2010). The Reactome event describes elevation of FIX activity due to gain-of-function mutation FIX R384L.",
"cellular_location": "extracellular region, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00742-1",
"P00740-1"
],
"evidence": [
{
"id": "R-HSA-9668253",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9668253"
}
]
},
{
"id": "R-HSA-9668365",
"name": "FVIIIa variant:FIXa does not convert FX to the active FXa",
"equation": "",
"summary": "The coagulation factor VIII (FVIII) in its activated form, FVIIIa, acts as a cofactor to the serine protease FIXa, in the conversion of the zymogen FX to the active enzyme (FXa). Factors VIIIa and IXa associate on cell surfaces to form a complex that very efficiently catalyzes the activation of factor X, the so-called \\intrinsic tenase complex\\. In vitro, negatively charged phospholipids can provide an appropriate surface. In the body, the surface is provided by the plasma membranes of activated platelets (Gilbert and Arena 1996). FVIII interaction with FIXa was localized to residues S577-Q584 (Fay P et al. 1994; O'Brien LM et al. 1995) and K726-N733 (Griffiths AE et al. 2013) in the A2 domain and to residues E1830-K1837 in the A3 domain (Lenting PJ et al. 1996; Bloem E et al. 2013). Missense mutations within the S577-Q584 region have been associated with mild/moderate hemophilia A (HA) (Amano K et al. 1998; Celie PH et al. 1999; Jenkins PV et al. 2002). A functional assay demonstrated that the effect of the mutations S577F, V578A, D579A, and Q584R is not to alter the affinity of FVIIIa for FIXa but rather to directly affect the catalytic rate constant of the complex, and thus the effect of the mutations is to reduce the cofactor potential of FVIII in FXa generation. (Jenkins PV et al. 2002). This conclusion is supported by fluorescence anisotropy data showing defective interaction of fluorescein-modified FIXa with mutant FVIIIa in the presence of FX (Jenkins PV et al. 2002). Other missense mutations in this region include a substitution of isoleucine to threonine at residue 585 (I585T) that creates a new N-linked glycosylation site at asparagine residue 583 resulting in defective procoagulant activity (Aly AM et al. 1992). Structural modeling showed that I585T creates a new asparagine\u2010linked glycosylation site and S577F introduces a bulky side chain, both of which could create steric hindrance impairing FIXa interaction with the S577-Q584 region (Amano K et al. 1998). In addition, in the three-dimensional FVIII model residues 530\u2013549 are located in close proximity to residues S577-Q584 (Pemberton S et al. 1997). Mutations in this segment, for example R546W, could also interfere with FVIIIa:FIXa-mediated stimulation of FX activation (Celie PH et al. 1999). The Reactome event describes failed generation of FXa as the functional consequence of the FIXa interaction with HA-associated FVIIIa variants due to reduced ability of defective FVIII to act as a cofactor for FIXa within the intrinsic tenase complex.",
"cellular_location": "extracellular region, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00742-1",
"P00740-1"
],
"evidence": [
{
"id": "R-HSA-9668365",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9668365"
}
]
},
{
"id": "R-HSA-9670874",
"name": "FIXa variant:FVIIIa does not convert FX to the active FXa",
"equation": "",
"summary": "Factor IX (FIX) is a vitamin K-dependent trypsin-like serine protease zymogen in plasma, which upon activation to its active form (FIXa), binds to cofactor VIIIa (FVIIIa) on negatively charged membrane surfaces in the presence of Ca2+ to activate factor X (FX) in the intrinsic pathway of the blood clotting cascade (Davie EW et al. 1991; Ngo JC et al. 2008). FIX deficiency is associated with mild to severe bleeding in hemophilia B (HB) patients (Rallapalli PM et al. 2013). HB is caused by a wide range of mutations that can include point mutations (nonsense and missense), insertions, deletions and other complex rearrangements of the F9 gene (Rallapalli PM et al. 2013). Exons 7 and 8 encode the catalytic domain of FIX, which is responsible for the subsequent activation of FX in the coagulation cascade. Disease-causing mutations at these exons 7 and 8 produce dysfunctional FIX with impaired clotting enzyme activity (Usharani P et al. 1985: Attree O et al. 1989; Bajaj SP et al. 1990; Spitzer SG et al. 1990; Ludwig M et al. 1992; Lu Q et al. 2015). The Reactome event describes failed generation of FXa as the functional consequence of the defective serine protease activity of hemophilia B (HB)-associated FIX variants such as G363R & G363E (Lu Q et al. 2015), G357E (Miyata T et al. 1991), A436V (Usharani P et al. 1985), I443T (Hamaguchi N et al. 1991), G409V (Bajaj SP et al. 1990), D410H and S411G (Ludwig M et al. 1992).",
"cellular_location": "extracellular region, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00742-1",
"P00740-1"
],
"evidence": [
{
"id": "R-HSA-9670874",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670874"
}
]
}
],
"reaction_participants": [
{
"participant_id": "R-HSA-140674",
"participant_name": "10xCbxE-F2(44-622) [extracellular region]",
"crossref": [
{
"id": "P00734",
"database": "UniProt",
"url": ""
},
{
"id": "3LDX",
"database": "PDB",
"url": ""
},
{
"id": "2CN0",
"database": "PDB",
"url": ""
},
{
"id": "1DWC",
"database": "PDB",
"url": ""
},
{
"id": "1DOJ",
"database": "PDB",
"url": ""
},
{
"id": "1DWB",
"database": "PDB",
"url": ""
},
{
"id": "3K65",
"database": "PDB",
"url": ""
},
{
"id": "5Z5X",
"database": "PDB",
"url": ""
},
{
"id": "6BJR",
"database": "PDB",
"url": ""
},
{
"id": "3LU9",
"database": "PDB",
"url": ""
},
{
"id": "1E0F",
"database": "PDB",
"url": ""
},
{
"id": "2FES",
"database": "PDB",
"url": ""
},
{
"id": "2FEQ",
"database": "PDB",
"url": ""
},
{
"id": "1DX5",
"database": "PDB",
"url": ""
},
{
"id": "1DWD",
"database": "PDB",
"url": ""
},
{
"id": "5Z5W",
"database": "PDB",
"url": ""
},
{
"id": "1DWE",
"database": "PDB",
"url": ""
},
{
"id": "6EO6",
"database": "PDB",
"url": ""
},
{
"id": "3P17",
"database": "PDB",
"url": ""
},
{
"id": "3NXP",
"database": "PDB",
"url": ""
},
{
"id": "1EOJ",
"database": "PDB",
"url": ""
},
{
"id": "6C2W",
"database": "PDB",
"url": ""
},
{
"id": "1EOL",
"database": "PDB",
"url": ""
},
{
"id": "2GDE",
"database": "PDB",
"url": ""
},
{
"id": "1EB1",
"database": "PDB",
"url": ""
},
{
"id": "6EO7",
"database": "PDB",
"url": ""
},
{
"id": "6EO9",
"database": "PDB",
"url": ""
},
{
"id": "6EO8",
"database": "PDB",
"url": ""
},
{
"id": "3P6Z",
"database": "PDB",
"url": ""
},
{
"id": "1FPC",
"database": "PDB",
"url": ""
},
{
"id": "2GP9",
"database": "PDB",
"url": ""
},
{
"id": "1FPH",
"database": "PDB",
"url": ""
},
{
"id": "1D3D",
"database": "PDB",
"url": ""
},
{
"id": "1D3P",
"database": "PDB",
"url": ""
},
{
"id": "5MJT",
"database": "PDB",
"url": ""
},
{
"id": "1CA8",
"database": "PDB",
"url": ""
},
{
"id": "3HKJ",
"database": "PDB",
"url": ""
},
{
"id": "2C8Z",
"database": "PDB",
"url": ""
},
{
"id": "1C5O",
"database": "PDB",
"url": ""
},
{
"id": "1D3Q",
"database": "PDB",
"url": ""
},
{
"id": "1D3T",
"database": "PDB",
"url": ""
},
{
"id": "3HTC",
"database": "PDB",
"url": ""
},
{
"id": "5MLS",
"database": "PDB",
"url": ""
},
{
"id": "2C90",
"database": "PDB",
"url": ""
},
{
"id": "2CF8",
"database": "PDB",
"url": ""
},
{
"id": "1D9I",
"database": "PDB",
"url": ""
},
{
"id": "3JZ1",
"database": "PDB",
"url": ""
},
{
"id": "1D4P",
"database": "PDB",
"url": ""
},
{
"id": "5NHU",
"database": "PDB",
"url": ""
},
{
"id": "5MM6",
"database": "PDB",
"url": ""
},
{
"id": "1D6W",
"database": "PDB",
"url": ""
},
{
"id": "2C93",
"database": "PDB",
"url": ""
},
{
"id": "P00734",
"database": "ZINC target",
"url": ""
},
{
"id": "2CF9",
"database": "PDB",
"url": ""
},
{
"id": "1DM4",
"database": "PDB",
"url": ""
},
{
"id": "1DIT",
"database": "PDB",
"url": ""
},
{
"id": "5TO3",
"database": "PDB",
"url": ""
},
{
"id": "1DE7",
"database": "PDB",
"url": ""
},
{
"id": "3JZ2",
"database": "PDB",
"url": ""
},
{
"id": "1HAO",
"database": "PDB",
"url": ""
},
{
"id": "2HWL",
"database": "PDB",
"url": ""
},
{
"id": "1HAI",
"database": "PDB",
"url": ""
},
{
"id": "3QGN",
"database": "PDB",
"url": ""
},
{
"id": "1HDT",
"database": "PDB",
"url": ""
},
{
"id": "1HGT",
"database": "PDB",
"url": ""
},
{
"id": "3QLP",
"database": "PDB",
"url": ""
},
{
"id": "1HAP",
"database": "PDB",
"url": ""
},
{
"id": "1HBT",
"database": "PDB",
"url": ""
},
{
"id": "2JH0",
"database": "PDB",
"url": ""
},
{
"id": "2JH6",
"database": "PDB",
"url": ""
},
{
"id": "1HUT",
"database": "PDB",
"url": ""
},
{
"id": "3QTO",
"database": "PDB",
"url": ""
},
{
"id": "1HLT",
"database": "PDB",
"url": ""
},
{
"id": "2JH5",
"database": "PDB",
"url": ""
},
{
"id": "1IHS",
"database": "PDB",
"url": ""
},
{
"id": "2OD3",
"database": "PDB",
"url": ""
},
{
"id": "1HXF",
"database": "PDB",
"url": ""
},
{
"id": "2362",
"database": "Guide to Pharmacology - Targets",
"url": ""
},
{
"id": "3QTV",
"database": "PDB",
"url": ""
},
{
"id": "1HXE",
"database": "PDB",
"url": ""
},
{
"id": "1G37",
"database": "PDB",
"url": ""
},
{
"id": "2HGT",
"database": "PDB",
"url": ""
},
{
"id": "1GHV",
"database": "PDB",
"url": ""
},
{
"id": "6V5T",
"database": "PDB",
"url": ""
},
{
"id": "3P70",
"database": "PDB",
"url": ""
},
{
"id": "7KME",
"database": "PDB",
"url": ""
},
{
"id": "2H9T",
"database": "PDB",
"url": ""
},
{
"id": "1G30",
"database": "PDB",
"url": ""
},
{
"id": "1G32",
"database": "PDB",
"url": ""
},
{
"id": "7TPP",
"database": "PDB",
"url": ""
},
{
"id": "1GHX",
"database": "PDB",
"url": ""
},
{
"id": "2HNT",
"database": "PDB",
"url": ""
},
{
"id": "8KME",
"database": "PDB",
"url": ""
},
{
"id": "3PMH",
"database": "PDB",
"url": ""
},
{
"id": "1GHW",
"database": "PDB",
"url": ""
},
{
"id": "1H8D",
"database": "PDB",
"url": ""
},
{
"id": "2HPP",
"database": "PDB",
"url": ""
},
{
"id": "THRB_HUMAN",
"database": "ZINC - Substances",
"url": ""
},
{
"id": "3PO1",
"database": "PDB",
"url": ""
},
{
"id": "1GJ5",
"database": "PDB",
"url": ""
},
{
"id": "1GHY",
"database": "PDB",
"url": ""
},
{
"id": "1GJ4",
"database": "PDB",
"url": ""
},
{
"id": "1HAH",
"database": "PDB",
"url": ""
},
{
"id": "1HAG",
"database": "PDB",
"url": ""
},
{
"id": "2HPQ",
"database": "PDB",
"url": ""
},
{
"id": "1H8I",
"database": "PDB",
"url": ""
},
{
"id": "3QDZ",
"database": "PDB",
"url": ""
},
{
"id": "3D49",
"database": "PDB",
"url": ""
},
{
"id": "5AFY",
"database": "PDB",
"url": ""
},
{
"id": "P00734",
"database": "GeneCards",
"url": ""
},
{
"id": "2A2X",
"database": "PDB",
"url": ""
},
{
"id": "2A0Q",
"database": "PDB",
"url": ""
},
{
"id": "1A46",
"database": "PDB",
"url": ""
},
{
"id": "3DD2",
"database": "PDB",
"url": ""
},
{
"id": "1A3E",
"database": "PDB",
"url": ""
},
{
"id": "THRB_HUMAN",
"database": "ZINC - Investigational",
"url": ""
},
{
"id": "1A4W",
"database": "PDB",
"url": ""
},
{
"id": "3DA9",
"database": "PDB",
"url": ""
},
{
"id": "2A45",
"database": "PDB",
"url": ""
},
{
"id": "1A3B",
"database": "PDB",
"url": ""
},
{
"id": "5AFZ",
"database": "PDB",
"url": ""
},
{
"id": "1A2C",
"database": "PDB",
"url": ""
},
{
"id": "1A61",
"database": "PDB",
"url": ""
},
{
"id": "3DHK",
"database": "PDB",
"url": ""
},
{
"id": "2AFQ",
"database": "PDB",
"url": ""
},
{
"id": "1A5G",
"database": "PDB",
"url": ""
},
{
"id": "5AHG",
"database": "PDB",
"url": ""
},
{
"id": "5DO4",
"database": "PDB",
"url": ""
},
{
"id": "5CMX",
"database": "PDB",
"url": ""
},
{
"id": "1AD8",
"database": "PDB",
"url": ""
},
{
"id": "1AE8",
"database": "PDB",
"url": ""
},
{
"id": "3DT0",
"database": "PDB",
"url": ""
},
{
"id": "2ANK",
"database": "PDB",
"url": ""
},
{
"id": "1ABI",
"database": "PDB",
"url": ""
},
{
"id": "5E8E",
"database": "PDB",
"url": ""
},
{
"id": "1ABJ",
"database": "PDB",
"url": ""
},
{
"id": "3BIV",
"database": "PDB",
"url": ""
},
{
"id": "4UD9",
"database": "PDB",
"url": ""
},
{
"id": "THRB_HUMAN",
"database": "ZINC - Metabolites",
"url": ""
},
{
"id": "4UDW",
"database": "PDB",
"url": ""
},
{
"id": "1Z8I",
"database": "PDB",
"url": ""
},
{
"id": "4UFD",
"database": "PDB",
"url": ""
},
{
"id": "1ZGI",
"database": "PDB",
"url": ""
},
{
"id": "4UEH",
"database": "PDB",
"url": ""
},
{
"id": "1Z8J",
"database": "PDB",
"url": ""
},
{
"id": "4UE7",
"database": "PDB",
"url": ""
},
{
"id": "4UFF",
"database": "PDB",
"url": ""
},
{
"id": "1ZGV",
"database": "PDB",
"url": ""
},
{
"id": "4UFG",
"database": "PDB",
"url": ""
},
{
"id": "3C1K",
"database": "PDB",
"url": ""
},
{
"id": "THRB_HUMAN",
"database": "ZINC - World Drugs",
"url": ""
},
{
"id": "3BV9",
"database": "PDB",
"url": ""
},
{
"id": "4UFE",
"database": "PDB",
"url": ""
},
{
"id": "5A2M",
"database": "PDB",
"url": ""
},
{
"id": "5AF9",
"database": "PDB",
"url": ""
},
{
"id": "3C27",
"database": "PDB",
"url": ""
},
{
"id": "1ZRB",
"database": "PDB",
"url": ""
},
{
"id": "4YES",
"database": "PDB",
"url": ""
},
{
"id": "1BTH",
"database": "PDB",
"url": ""
},
{
"id": "3F68",
"database": "PDB",
"url": ""
},
{
"id": "2BXU",
"database": "PDB",
"url": ""
},
{
"id": "1BMN",
"database": "PDB",
"url": ""
},
{
"id": "5GIM",
"database": "PDB",
"url": ""
},
{
"id": "1BMM",
"database": "PDB",
"url": ""
},
{
"id": "3EQ0",
"database": "PDB",
"url": ""
},
{
"id": "P00734",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "5JFD",
"database": "PDB",
"url": ""
},
{
"id": "3GIC",
"database": "PDB",
"url": ""
},
{
"id": "1C1V",
"database": "PDB",
"url": ""
},
{
"id": "2C8W",
"database": "PDB",
"url": ""
},
{
"id": "1C1U",
"database": "PDB",
"url": ""
},
{
"id": "5JDU",
"database": "PDB",
"url": ""
},
{
"id": "3GIS",
"database": "PDB",
"url": ""
},
{
"id": "1C4V",
"database": "PDB",
"url": ""
},
{
"id": "1C4Y",
"database": "PDB",
"url": ""
},
{
"id": "5JZY",
"database": "PDB",
"url": ""
},
{
"id": "2C8X",
"database": "PDB",
"url": ""
},
{
"id": "1C1W",
"database": "PDB",
"url": ""
},
{
"id": "1C4U",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000180210",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000308541",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000311907",
"database": "Ensembl",
"url": ""
},
{
"id": "1C5N",
"database": "PDB",
"url": ""
},
{
"id": "5L6N",
"database": "PDB",
"url": ""
},
{
"id": "3HAT",
"database": "PDB",
"url": ""
},
{
"id": "2C8Y",
"database": "PDB",
"url": ""
},
{
"id": "1C5L",
"database": "PDB",
"url": ""
},
{
"id": "5EDM",
"database": "PDB",
"url": ""
},
{
"id": "1AI8",
"database": "PDB",
"url": ""
},
{
"id": "1AHT",
"database": "PDB",
"url": ""
},
{
"id": "2ANM",
"database": "PDB",
"url": ""
},
{
"id": "3DUX",
"database": "PDB",
"url": ""
},
{
"id": "1AFE",
"database": "PDB",
"url": ""
},
{
"id": "5EDK",
"database": "PDB",
"url": ""
},
{
"id": "1AWH",
"database": "PDB",
"url": ""
},
{
"id": "2BDY",
"database": "PDB",
"url": ""
},
{
"id": "1AY6",
"database": "PDB",
"url": ""
},
{
"id": "5EW1",
"database": "PDB",
"url": ""
},
{
"id": "3E6P",
"database": "PDB",
"url": ""
},
{
"id": "1AIX",
"database": "PDB",
"url": ""
},
{
"id": "1AWF",
"database": "PDB",
"url": ""
},
{
"id": "2B5T",
"database": "PDB",
"url": ""
},
{
"id": "2BVS",
"database": "PDB",
"url": ""
},
{
"id": "2BVX",
"database": "PDB",
"url": ""
},
{
"id": "1B7X",
"database": "PDB",
"url": ""
},
{
"id": "5EW2",
"database": "PDB",
"url": ""
},
{
"id": "1BA8",
"database": "PDB",
"url": ""
},
{
"id": "1B5G",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000180210-F2",
"database": "HPA",
"url": ""
},
{
"id": "2BVR",
"database": "PDB",
"url": ""
},
{
"id": "3EE0",
"database": "PDB",
"url": ""
},
{
"id": "1BHX",
"database": "PDB",
"url": ""
},
{
"id": "2BXT",
"database": "PDB",
"url": ""
},
{
"id": "1BCU",
"database": "PDB",
"url": ""
},
{
"id": "5GDS",
"database": "PDB",
"url": ""
},
{
"id": "1BB0",
"database": "PDB",
"url": ""
},
{
"id": "3EGK",
"database": "PDB",
"url": ""
},
{
"id": "1THR",
"database": "PDB",
"url": ""
},
{
"id": "2ZHF",
"database": "PDB",
"url": ""
},
{
"id": "1THS",
"database": "PDB",
"url": ""
},
{
"id": "4CH8",
"database": "PDB",
"url": ""
},
{
"id": "4CH2",
"database": "PDB",
"url": ""
},
{
"id": "1TBZ",
"database": "PDB",
"url": ""
},
{
"id": "1THP",
"database": "PDB",
"url": ""
},
{
"id": "1TMB",
"database": "PDB",
"url": ""
},
{
"id": "2ZHQ",
"database": "PDB",
"url": ""
},
{
"id": "1TMT",
"database": "PDB",
"url": ""
},
{
"id": "4DIH",
"database": "PDB",
"url": ""
},
{
"id": "4DII",
"database": "PDB",
"url": ""
},
{
"id": "1TQ0",
"database": "PDB",
"url": ""
},
{
"id": "2ZHW",
"database": "PDB",
"url": ""
},
{
"id": "1TOM",
"database": "PDB",
"url": ""
},
{
"id": "4DT7",
"database": "PDB",
"url": ""
},
{
"id": "4DY7",
"database": "PDB",
"url": ""
},
{
"id": "1TMU",
"database": "PDB",
"url": ""
},
{
"id": "1UMA",
"database": "PDB",
"url": ""
},
{
"id": "1TWX",
"database": "PDB",
"url": ""
},
{
"id": "4E06",
"database": "PDB",
"url": ""
},
{
"id": "2ZI2",
"database": "PDB",
"url": ""
},
{
"id": "1TQ7",
"database": "PDB",
"url": ""
},
{
"id": "4E05",
"database": "PDB",
"url": ""
},
{
"id": "4AZ2",
"database": "PDB",
"url": ""
},
{
"id": "4BAH",
"database": "PDB",
"url": ""
},
{
"id": "1SGI",
"database": "PDB",
"url": ""
},
{
"id": "1SG8",
"database": "PDB",
"url": ""
},
{
"id": "4AYY",
"database": "PDB",
"url": ""
},
{
"id": "2ZFR",
"database": "PDB",
"url": ""
},
{
"id": "4BAM",
"database": "PDB",
"url": ""
},
{
"id": "1SR5",
"database": "PDB",
"url": ""
},
{
"id": "1T4U",
"database": "PDB",
"url": ""
},
{
"id": "4BAK",
"database": "PDB",
"url": ""
},
{
"id": "1SL3",
"database": "PDB",
"url": ""
},
{
"id": "2ZG0",
"database": "PDB",
"url": ""
},
{
"id": "1SHH",
"database": "PDB",
"url": ""
},
{
"id": "4BAO",
"database": "PDB",
"url": ""
},
{
"id": "2ZGX",
"database": "PDB",
"url": ""
},
{
"id": "1T4V",
"database": "PDB",
"url": ""
},
{
"id": "1TA2",
"database": "PDB",
"url": ""
},
{
"id": "4BAN",
"database": "PDB",
"url": ""
},
{
"id": "2ZGB",
"database": "PDB",
"url": ""
},
{
"id": "2ZHE",
"database": "PDB",
"url": ""
},
{
"id": "HMDBP13521",
"database": "HMDB Protein",
"url": ""
},
{
"id": "4BAQ",
"database": "PDB",
"url": ""
},
{
"id": "4BOH",
"database": "PDB",
"url": ""
},
{
"id": "1TA6",
"database": "PDB",
"url": ""
},
{
"id": "1TB6",
"database": "PDB",
"url": ""
},
{
"id": "4MLF",
"database": "PDB",
"url": ""
},
{
"id": "1YPJ",
"database": "PDB",
"url": ""
},
{
"id": "1YPG",
"database": "PDB",
"url": ""
},
{
"id": "3BEF",
"database": "PDB",
"url": ""
},
{
"id": "4LZ4",
"database": "PDB",
"url": ""
},
{
"id": "THRB_HUMAN",
"database": "ZINC - Biogenic",
"url": ""
},
{
"id": "1YPE",
"database": "PDB",
"url": ""
},
{
"id": "4NZQ",
"database": "PDB",
"url": ""
},
{
"id": "1YPK",
"database": "PDB",
"url": ""
},
{
"id": "4O03",
"database": "PDB",
"url": ""
},
{
"id": "THRB_HUMAN",
"database": "ZINC - FDA approved",
"url": ""
},
{
"id": "NP_001298186.1",
"database": "RefSeq",
"url": ""
},
{
"id": "4RKJ",
"database": "PDB",
"url": ""
},
{
"id": "4RKO",
"database": "PDB",
"url": ""
},
{
"id": "1YPL",
"database": "PDB",
"url": ""
},
{
"id": "3BEI",
"database": "PDB",
"url": ""
},
{
"id": "NP_000497.1",
"database": "RefSeq",
"url": ""
},
{
"id": "3BIU",
"database": "PDB",
"url": ""
},
{
"id": "4THN",
"database": "PDB",
"url": ""
},
{
"id": "1Z71",
"database": "PDB",
"url": ""
},
{
"id": "1YPM",
"database": "PDB",
"url": ""
},
{
"id": "4RN6",
"database": "PDB",
"url": ""
},
{
"id": "3BF6",
"database": "PDB",
"url": ""
},
{
"id": "4H6T",
"database": "PDB",
"url": ""
},
{
"id": "2ZIQ",
"database": "PDB",
"url": ""
},
{
"id": "1UVS",
"database": "PDB",
"url": ""
},
{
"id": "1VR1",
"database": "PDB",
"url": ""
},
{
"id": "4E7R",
"database": "PDB",
"url": ""
},
{
"id": "4H6S",
"database": "PDB",
"url": ""
},
{
"id": "4HTC",
"database": "PDB",
"url": ""
},
{
"id": "4HZH",
"database": "PDB",
"url": ""
},
{
"id": "THRB_HUMAN",
"database": "ZINC - Predictions - Purchasable",
"url": ""
},
{
"id": "1WAY",
"database": "PDB",
"url": ""
},
{
"id": "2ZNK",
"database": "PDB",
"url": ""
},
{
"id": "1W7G",
"database": "PDB",
"url": ""
},
{
"id": "4HFP",
"database": "PDB",
"url": ""
},
{
"id": "1VZQ",
"database": "PDB",
"url": ""
},
{
"id": "4I7Y",
"database": "PDB",
"url": ""
},
{
"id": "1XM1",
"database": "PDB",
"url": ""
},
{
"id": "1WBG",
"database": "PDB",
"url": ""
},
{
"id": "2ZO3",
"database": "PDB",
"url": ""
},
{
"id": "4LXB",
"database": "PDB",
"url": ""
},
{
"id": "3B9F",
"database": "PDB",
"url": ""
},
{
"id": "4LZ1",
"database": "PDB",
"url": ""
},
{
"id": "3B23",
"database": "PDB",
"url": ""
},
{
"id": "4LOY",
"database": "PDB",
"url": ""
},
{
"id": "1XMN",
"database": "PDB",
"url": ""
},
{
"id": "3RMO",
"database": "PDB",
"url": ""
},
{
"id": "1MU6",
"database": "PDB",
"url": ""
},
{
"id": "2THF",
"database": "PDB",
"url": ""
},
{
"id": "3RMN",
"database": "PDB",
"url": ""
},
{
"id": "1MH0",
"database": "PDB",
"url": ""
},
{
"id": "3RMM",
"database": "PDB",
"url": ""
},
{
"id": "1LHF",
"database": "PDB",
"url": ""
},
{
"id": "1LHG",
"database": "PDB",
"url": ""
},
{
"id": "3S7H",
"database": "PDB",
"url": ""
},
{
"id": "2UUF",
"database": "PDB",
"url": ""
},
{
"id": "1MUE",
"database": "PDB",
"url": ""
},
{
"id": "3S7K",
"database": "PDB",
"url": ""
},
{
"id": "1MU8",
"database": "PDB",
"url": ""
},
{
"id": "1NRN",
"database": "PDB",
"url": ""
},
{
"id": "3SHA",
"database": "PDB",
"url": ""
},
{
"id": "3SHC",
"database": "PDB",
"url": ""
},
{
"id": "2UUJ",
"database": "PDB",
"url": ""
},
{
"id": "1NO9",
"database": "PDB",
"url": ""
},
{
"id": "1NM6",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000180210",
"database": "OpenTargets",
"url": ""
},
{
"id": "3SI3",
"database": "PDB",
"url": ""
},
{
"id": "1NRP",
"database": "PDB",
"url": ""
},
{
"id": "3SI4",
"database": "PDB",
"url": ""
},
{
"id": "1NRQ",
"database": "PDB",
"url": ""
},
{
"id": "1NRO",
"database": "PDB",
"url": ""
},
{
"id": "2UUK",
"database": "PDB",
"url": ""
},
{
"id": "1JMO",
"database": "PDB",
"url": ""
},
{
"id": "1JOU",
"database": "PDB",
"url": ""
},
{
"id": "2PGB",
"database": "PDB",
"url": ""
},
{
"id": "1IHT",
"database": "PDB",
"url": ""
},
{
"id": "3QWC",
"database": "PDB",
"url": ""
},
{
"id": "3R3G",
"database": "PDB",
"url": ""
},
{
"id": "1K22",
"database": "PDB",
"url": ""
},
{
"id": "2PGQ",
"database": "PDB",
"url": ""
},
{
"id": "1JWT",
"database": "PDB",
"url": ""
},
{
"id": "1K21",
"database": "PDB",
"url": ""
},
{
"id": "3QX5",
"database": "PDB",
"url": ""
},
{
"id": "3RLW",
"database": "PDB",
"url": ""
},
{
"id": "1LHC",
"database": "PDB",
"url": ""
},
{
"id": "3RLY",
"database": "PDB",
"url": ""
},
{
"id": "1KTT",
"database": "PDB",
"url": ""
},
{
"id": "1KTS",
"database": "PDB",
"url": ""
},
{
"id": "2PKS",
"database": "PDB",
"url": ""
},
{
"id": "3RM2",
"database": "PDB",
"url": ""
},
{
"id": "3RML",
"database": "PDB",
"url": ""
},
{
"id": "2R2M",
"database": "PDB",
"url": ""
},
{
"id": "1LHD",
"database": "PDB",
"url": ""
},
{
"id": "1LHE",
"database": "PDB",
"url": ""
},
{
"id": "2PW8",
"database": "PDB",
"url": ""
},
{
"id": "3RM0",
"database": "PDB",
"url": ""
},
{
"id": "1QBV",
"database": "PDB",
"url": ""
},
{
"id": "1QHR",
"database": "PDB",
"url": ""
},
{
"id": "3U98",
"database": "PDB",
"url": ""
},
{
"id": "2ZF0",
"database": "PDB",
"url": ""
},
{
"id": "3U8T",
"database": "PDB",
"url": ""
},
{
"id": "1P8V",
"database": "PDB",
"url": ""
},
{
"id": "1PPB",
"database": "PDB",
"url": ""
},
{
"id": "1QJ1",
"database": "PDB",
"url": ""
},
{
"id": "1QJ6",
"database": "PDB",
"url": ""
},
{
"id": "2ZFF",
"database": "PDB",
"url": ""
},
{
"id": "3U9A",
"database": "PDB",
"url": ""
},
{
"id": "3UTU",
"database": "PDB",
"url": ""
},
{
"id": "3VXE",
"database": "PDB",
"url": ""
},
{
"id": "1QJ7",
"database": "PDB",
"url": ""
},
{
"id": "1QUR",
"database": "PDB",
"url": ""
},
{
"id": "3UWJ",
"database": "PDB",
"url": ""
},
{
"id": "2ZFP",
"database": "PDB",
"url": ""
},
{
"id": "3U8O",
"database": "PDB",
"url": ""
},
{
"id": "1OYT",
"database": "PDB",
"url": ""
},
{
"id": "1OOK",
"database": "PDB",
"url": ""
},
{
"id": "3U8R",
"database": "PDB",
"url": ""
},
{
"id": "2ZDV",
"database": "PDB",
"url": ""
},
{
"id": "1O5G",
"database": "PDB",
"url": ""
},
{
"id": "3U69",
"database": "PDB",
"url": ""
},
{
"id": "2ZDA",
"database": "PDB",
"url": ""
},
{
"id": "1O2G",
"database": "PDB",
"url": ""
},
{
"id": "3TU7",
"database": "PDB",
"url": ""
},
{
"id": "1NU9",
"database": "PDB",
"url": ""
},
{
"id": "16013",
"database": "Orphanet",
"url": ""
},
{
"id": "2V3O",
"database": "PDB",
"url": ""
},
{
"id": "1NY2",
"database": "PDB",
"url": ""
},
{
"id": "3T5F",
"database": "PDB",
"url": ""
},
{
"id": "3SV2",
"database": "PDB",
"url": ""
},
{
"id": "1O0D",
"database": "PDB",
"url": ""
},
{
"id": "1NZQ",
"database": "PDB",
"url": ""
},
{
"id": "2ZC9",
"database": "PDB",
"url": ""
},
{
"id": "2V3H",
"database": "PDB",
"url": ""
},
{
"id": "1NRS",
"database": "PDB",
"url": ""
},
{
"id": "1NT1",
"database": "PDB",
"url": ""
},
{
"id": "1NRR",
"database": "PDB",
"url": ""
},
{
"id": "3SQE",
"database": "PDB",
"url": ""
},
{
"id": "1NU7",
"database": "PDB",
"url": ""
},
{
"id": "3SQH",
"database": "PDB",
"url": ""
},
{
"id": "1RIW",
"database": "PDB",
"url": ""
},
{
"id": "4AX9",
"database": "PDB",
"url": ""
},
{
"id": "P00734",
"database": "PRO",
"url": ""
},
{
"id": "1RD3",
"database": "PDB",
"url": ""
},
{
"id": "2ZFQ",
"database": "PDB",
"url": ""
},
{
"id": "3VXF",
"database": "PDB",
"url": ""
},
{
"id": "1SFQ",
"database": "PDB",
"url": ""
},
{
"id": "4AYV",
"database": "PDB",
"url": ""
},
{
"id": "1SB1",
"database": "PDB",
"url": ""
}
]
},
{
"participant_id": "R-HSA-140689",
"participant_name": "factor Xa [extracellular region]",
"crossref": [
{
"id": "CPX-6215",
"database": "ComplexPortal",
"url": ""
}
]
},
{
"participant_id": "R-HSA-140739",
"participant_name": "factor X [extracellular region]",
"crossref": [
{
"id": "CPX-6215",
"database": "ComplexPortal",
"url": ""
}
]
},
{
"participant_id": "R-HSA-140785",
"participant_name": "factor X activation peptide [extracellular region]",
"crossref": [
{
"id": "6RK9",
"database": "PDB",
"url": ""
},
{
"id": "4ZH8",
"database": "PDB",
"url": ""
},
{
"id": "4A7I",
"database": "PDB",
"url": ""
},
{
"id": "3KQC",
"database": "PDB",
"url": ""
},
{
"id": "4Y79",
"database": "PDB",
"url": ""
},
{
"id": "P00742",
"database": "GeneCards",
"url": ""
},
{
"id": "2XBY",
"database": "PDB",
"url": ""
},
{
"id": "1FAX",
"database": "PDB",
"url": ""
},
{
"id": "3ENS",
"database": "PDB",
"url": ""
},
{
"id": "3LIW",
"database": "PDB",
"url": ""
},
{
"id": "2EI6",
"database": "PDB",
"url": ""
},
{
"id": "1IQI",
"database": "PDB",
"url": ""
},
{
"id": "2W3K",
"database": "PDB",
"url": ""
},
{
"id": "6YYW",
"database": "PDB",
"url": ""
},
{
"id": "4BTT",
"database": "PDB",
"url": ""
},
{
"id": "3K9X",
"database": "PDB",
"url": ""
},
{
"id": "2G00",
"database": "PDB",
"url": ""
},
{
"id": "2PHB",
"database": "PDB",
"url": ""
},
{
"id": "HMDBP02011",
"database": "HMDB Protein",
"url": ""
},
{
"id": "1G2M",
"database": "PDB",
"url": ""
},
{
"id": "2P16",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000126218-F10",
"database": "HPA",
"url": ""
},
{
"id": "2H9E",
"database": "PDB",
"url": ""
},
{
"id": "2VWN",
"database": "PDB",
"url": ""
},
{
"id": "5K0H",
"database": "PDB",
"url": ""
},
{
"id": "2UWO",
"database": "PDB",
"url": ""
},
{
"id": "16008",
"database": "Orphanet",
"url": ""
},
{
"id": "2Y81",
"database": "PDB",
"url": ""
},
{
"id": "1NFU",
"database": "PDB",
"url": ""
},
{
"id": "2EI8",
"database": "PDB",
"url": ""
},
{
"id": "1Z6E",
"database": "PDB",
"url": ""
},
{
"id": "FA10_HUMAN",
"database": "ZINC - Substances",
"url": ""
},
{
"id": "4Y71",
"database": "PDB",
"url": ""
},
{
"id": "1MQ5",
"database": "PDB",
"url": ""
},
{
"id": "2D1J",
"database": "PDB",
"url": ""
},
{
"id": "1FXY",
"database": "PDB",
"url": ""
},
{
"id": "2JKH",
"database": "PDB",
"url": ""
},
{
"id": "3SW2",
"database": "PDB",
"url": ""
},
{
"id": "2Y7X",
"database": "PDB",
"url": ""
},
{
"id": "3HPT",
"database": "PDB",
"url": ""
},
{
"id": "4Y6D",
"database": "PDB",
"url": ""
},
{
"id": "1IOE",
"database": "PDB",
"url": ""
},
{
"id": "1XKB",
"database": "PDB",
"url": ""
},
{
"id": "2EI7",
"database": "PDB",
"url": ""
},
{
"id": "7TPP",
"database": "PDB",
"url": ""
},
{
"id": "1F0S",
"database": "PDB",
"url": ""
},
{
"id": "2BOH",
"database": "PDB",
"url": ""
},
{
"id": "1C5M",
"database": "PDB",
"url": ""
},
{
"id": "3CS7",
"database": "PDB",
"url": ""
},
{
"id": "1IQH",
"database": "PDB",
"url": ""
},
{
"id": "3M37",
"database": "PDB",
"url": ""
},
{
"id": "3KL6",
"database": "PDB",
"url": ""
},
{
"id": "1NFY",
"database": "PDB",
"url": ""
},
{
"id": "2J2U",
"database": "PDB",
"url": ""
},
{
"id": "P00742",
"database": "ZINC target",
"url": ""
},
{
"id": "6YYY",
"database": "PDB",
"url": ""
},
{
"id": "NP_001299604.1",
"database": "RefSeq",
"url": ""
},
{
"id": "6Q9I",
"database": "PDB",
"url": ""
},
{
"id": "2VWO",
"database": "PDB",
"url": ""
},
{
"id": "3KQD",
"database": "PDB",
"url": ""
},
{
"id": "2RA0",
"database": "PDB",
"url": ""
},
{
"id": "4Y76",
"database": "PDB",
"url": ""
},
{
"id": "7YBB",
"database": "PDB",
"url": ""
},
{
"id": "2VVC",
"database": "PDB",
"url": ""
},
{
"id": "2XBX",
"database": "PDB",
"url": ""
},
{
"id": "2P94",
"database": "PDB",
"url": ""
},
{
"id": "6YYX",
"database": "PDB",
"url": ""
},
{
"id": "2P93",
"database": "PDB",
"url": ""
},
{
"id": "2XC0",
"database": "PDB",
"url": ""
},
{
"id": "1FJS",
"database": "PDB",
"url": ""
},
{
"id": "1LPG",
"database": "PDB",
"url": ""
},
{
"id": "4BTI",
"database": "PDB",
"url": ""
},
{
"id": "1F0R",
"database": "PDB",
"url": ""
},
{
"id": "7TPQ",
"database": "PDB",
"url": ""
},
{
"id": "4Y7B",
"database": "PDB",
"url": ""
},
{
"id": "2BOK",
"database": "PDB",
"url": ""
},
{
"id": "FA10_HUMAN",
"database": "ZINC - World Drugs",
"url": ""
},
{
"id": "2GD4",
"database": "PDB",
"url": ""
},
{
"id": "3FFG",
"database": "PDB",
"url": ""
},
{
"id": "1XKA",
"database": "PDB",
"url": ""
},
{
"id": "2CJI",
"database": "PDB",
"url": ""
},
{
"id": "2Q1J",
"database": "PDB",
"url": ""
},
{
"id": "2J95",
"database": "PDB",
"url": ""
},
{
"id": "7AHU",
"database": "PDB",
"url": ""
},
{
"id": "2P95",
"database": "PDB",
"url": ""
},
{
"id": "6Z6Q",
"database": "PDB",
"url": ""
},
{
"id": "5JZ8",
"database": "PDB",
"url": ""
},
{
"id": "2P3F",
"database": "PDB",
"url": ""
},
{
"id": "2VH6",
"database": "PDB",
"url": ""
},
{
"id": "P00742",
"database": "UniProt",
"url": ""
},
{
"id": "2VWM",
"database": "PDB",
"url": ""
},
{
"id": "2BQ6",
"database": "PDB",
"url": ""
},
{
"id": "1NFW",
"database": "PDB",
"url": ""
},
{
"id": "2J34",
"database": "PDB",
"url": ""
},
{
"id": "7BMI",
"database": "PDB",
"url": ""
},
{
"id": "FA10_HUMAN",
"database": "ZINC - Investigational",
"url": ""
},
{
"id": "2359",
"database": "Guide to Pharmacology - Targets",
"url": ""
},
{
"id": "2VVV",
"database": "PDB",
"url": ""
},
{
"id": "1IQJ",
"database": "PDB",
"url": ""
},
{
"id": "2XBV",
"database": "PDB",
"url": ""
},
{
"id": "FA10_HUMAN",
"database": "ZINC - Predictions - Purchasable",
"url": ""
},
{
"id": "3Q3K",
"database": "PDB",
"url": ""
},
{
"id": "P00742",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "2W3I",
"database": "PDB",
"url": ""
},
{
"id": "3IIT",
"database": "PDB",
"url": ""
},
{
"id": "2PR3",
"database": "PDB",
"url": ""
},
{
"id": "1IQG",
"database": "PDB",
"url": ""
},
{
"id": "2J94",
"database": "PDB",
"url": ""
},
{
"id": "1EZQ",
"database": "PDB",
"url": ""
},
{
"id": "6Q9F",
"database": "PDB",
"url": ""
},
{
"id": "2WYJ",
"database": "PDB",
"url": ""
},
{
"id": "2Y5H",
"database": "PDB",
"url": ""
},
{
"id": "3KQE",
"database": "PDB",
"url": ""
},
{
"id": "2XC4",
"database": "PDB",
"url": ""
},
{
"id": "FA10_HUMAN",
"database": "ZINC - FDA approved",
"url": ""
},
{
"id": "2P3T",
"database": "PDB",
"url": ""
},
{
"id": "3TK6",
"database": "PDB",
"url": ""
},
{
"id": "2VWL",
"database": "PDB",
"url": ""
},
{
"id": "2J4I",
"database": "PDB",
"url": ""
},
{
"id": "1WU1",
"database": "PDB",
"url": ""
},
{
"id": "5VOF",
"database": "PDB",
"url": ""
},
{
"id": "1LPZ",
"database": "PDB",
"url": ""
},
{
"id": "2Y5F",
"database": "PDB",
"url": ""
},
{
"id": "7E6J",
"database": "PDB",
"url": ""
},
{
"id": "5JQY",
"database": "PDB",
"url": ""
},
{
"id": "5VOE",
"database": "PDB",
"url": ""
},
{
"id": "2VH0",
"database": "PDB",
"url": ""
},
{
"id": "2J38",
"database": "PDB",
"url": ""
},
{
"id": "FA10_HUMAN",
"database": "ZINC - Biogenic",
"url": ""
},
{
"id": "3M36",
"database": "PDB",
"url": ""
},
{
"id": "2Y5G",
"database": "PDB",
"url": ""
},
{
"id": "2BMG",
"database": "PDB",
"url": ""
},
{
"id": "1KSN",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000126218",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000126218",
"database": "OpenTargets",
"url": ""
},
{
"id": "1IQE",
"database": "PDB",
"url": ""
},
{
"id": "4ZHA",
"database": "PDB",
"url": ""
},
{
"id": "1IQM",
"database": "PDB",
"url": ""
},
{
"id": "1MQ6",
"database": "PDB",
"url": ""
},
{
"id": "6Z6R",
"database": "PDB",
"url": ""
},
{
"id": "1IQL",
"database": "PDB",
"url": ""
},
{
"id": "1G2L",
"database": "PDB",
"url": ""
},
{
"id": "P00742",
"database": "PRO",
"url": ""
},
{
"id": "2P3U",
"database": "PDB",
"url": ""
},
{
"id": "2BQ7",
"database": "PDB",
"url": ""
},
{
"id": "2VVU",
"database": "PDB",
"url": ""
},
{
"id": "2Y82",
"database": "PDB",
"url": ""
},
{
"id": "1V3X",
"database": "PDB",
"url": ""
},
{
"id": "2XBW",
"database": "PDB",
"url": ""
},
{
"id": "4BTU",
"database": "PDB",
"url": ""
},
{
"id": "7YB9",
"database": "PDB",
"url": ""
},
{
"id": "7BMJ",
"database": "PDB",
"url": ""
},
{
"id": "2UWL",
"database": "PDB",
"url": ""
},
{
"id": "2FZZ",
"database": "PDB",
"url": ""
},
{
"id": "5JZU",
"database": "PDB",
"url": ""
},
{
"id": "NP_000495.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENST00000375559",
"database": "Ensembl",
"url": ""
},
{
"id": "3CEN",
"database": "PDB",
"url": ""
},
{
"id": "5JTC",
"database": "PDB",
"url": ""
},
{
"id": "2XC5",
"database": "PDB",
"url": ""
},
{
"id": "1NFX",
"database": "PDB",
"url": ""
},
{
"id": "1IQN",
"database": "PDB",
"url": ""
},
{
"id": "2Y7Z",
"database": "PDB",
"url": ""
},
{
"id": "1LQD",
"database": "PDB",
"url": ""
},
{
"id": "3KQB",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000364709",
"database": "Ensembl",
"url": ""
},
{
"id": "7YBC",
"database": "PDB",
"url": ""
},
{
"id": "2WYG",
"database": "PDB",
"url": ""
},
{
"id": "1IQF",
"database": "PDB",
"url": ""
},
{
"id": "1LPK",
"database": "PDB",
"url": ""
},
{
"id": "2BQW",
"database": "PDB",
"url": ""
},
{
"id": "2W26",
"database": "PDB",
"url": ""
},
{
"id": "NP_001299603.1",
"database": "RefSeq",
"url": ""
},
{
"id": "3TK5",
"database": "PDB",
"url": ""
},
{
"id": "1P0S",
"database": "PDB",
"url": ""
},
{
"id": "1IQK",
"database": "PDB",
"url": ""
},
{
"id": "2Y80",
"database": "PDB",
"url": ""
},
{
"id": "2UWP",
"database": "PDB",
"url": ""
},
{
"id": "4Y7A",
"database": "PDB",
"url": ""
},
{
"id": "1HCG",
"database": "PDB",
"url": ""
}
]
},
{
"participant_id": "R-HSA-140786",
"participant_name": "10xCbxE-F2(44-327) [extracellular region]",
"crossref": [
{
"id": "1AWF",
"database": "PDB",
"url": ""
},
{
"id": "1HLT",
"database": "PDB",
"url": ""
},
{
"id": "3SHC",
"database": "PDB",
"url": ""
},
{
"id": "2V3O",
"database": "PDB",
"url": ""
},
{
"id": "3BIV",
"database": "PDB",
"url": ""
},
{
"id": "1TA6",
"database": "PDB",
"url": ""
},
{
"id": "1D3T",
"database": "PDB",
"url": ""
},
{
"id": "4HZH",
"database": "PDB",
"url": ""
},
{
"id": "1C1V",
"database": "PDB",
"url": ""
},
{
"id": "1LHE",
"database": "PDB",
"url": ""
},
{
"id": "2HPQ",
"database": "PDB",
"url": ""
},
{
"id": "4DT7",
"database": "PDB",
"url": ""
},
{
"id": "P00734",
"database": "PRO",
"url": ""
},
{
"id": "1SR5",
"database": "PDB",
"url": ""
},
{
"id": "5AFZ",
"database": "PDB",
"url": ""
},
{
"id": "1QJ7",
"database": "PDB",
"url": ""
},
{
"id": "5TO3",
"database": "PDB",
"url": ""
},
{
"id": "1XMN",
"database": "PDB",
"url": ""
},
{
"id": "3HAT",
"database": "PDB",
"url": ""
},
{
"id": "1EB1",
"database": "PDB",
"url": ""
},
{
"id": "1YPL",
"database": "PDB",
"url": ""
},
{
"id": "4UFE",
"database": "PDB",
"url": ""
},
{
"id": "3R3G",
"database": "PDB",
"url": ""
},
{
"id": "1G32",
"database": "PDB",
"url": ""
},
{
"id": "3EGK",
"database": "PDB",
"url": ""
},
{
"id": "6BJR",
"database": "PDB",
"url": ""
},
{
"id": "2BXU",
"database": "PDB",
"url": ""
},
{
"id": "3BF6",
"database": "PDB",
"url": ""
},
{
"id": "1D3D",
"database": "PDB",
"url": ""
},
{
"id": "3RLY",
"database": "PDB",
"url": ""
},
{
"id": "2HPP",
"database": "PDB",
"url": ""
},
{
"id": "1TMB",
"database": "PDB",
"url": ""
},
{
"id": "2ZDV",
"database": "PDB",
"url": ""
},
{
"id": "5CMX",
"database": "PDB",
"url": ""
},
{
"id": "1T4V",
"database": "PDB",
"url": ""
},
{
"id": "1HGT",
"database": "PDB",
"url": ""
},
{
"id": "1LHG",
"database": "PDB",
"url": ""
},
{
"id": "1AFE",
"database": "PDB",
"url": ""
},
{
"id": "1NRS",
"database": "PDB",
"url": ""
},
{
"id": "4E05",
"database": "PDB",
"url": ""
},
{
"id": "1A46",
"database": "PDB",
"url": ""
},
{
"id": "1P8V",
"database": "PDB",
"url": ""
},
{
"id": "5NHU",
"database": "PDB",
"url": ""
},
{
"id": "1XM1",
"database": "PDB",
"url": ""
},
{
"id": "2C8X",
"database": "PDB",
"url": ""
},
{
"id": "1DWE",
"database": "PDB",
"url": ""
},
{
"id": "1YPE",
"database": "PDB",
"url": ""
},
{
"id": "1Z8J",
"database": "PDB",
"url": ""
},
{
"id": "1NRQ",
"database": "PDB",
"url": ""
},
{
"id": "1G37",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000180210-F2",
"database": "HPA",
"url": ""
},
{
"id": "1SFQ",
"database": "PDB",
"url": ""
},
{
"id": "2ZG0",
"database": "PDB",
"url": ""
},
{
"id": "2AFQ",
"database": "PDB",
"url": ""
},
{
"id": "3U8O",
"database": "PDB",
"url": ""
},
{
"id": "2HWL",
"database": "PDB",
"url": ""
},
{
"id": "3RMN",
"database": "PDB",
"url": ""
},
{
"id": "1AI8",
"database": "PDB",
"url": ""
},
{
"id": "3P6Z",
"database": "PDB",
"url": ""
},
{
"id": "4THN",
"database": "PDB",
"url": ""
},
{
"id": "1ZRB",
"database": "PDB",
"url": ""
},
{
"id": "1K21",
"database": "PDB",
"url": ""
},
{
"id": "8KME",
"database": "PDB",
"url": ""
},
{
"id": "4CH8",
"database": "PDB",
"url": ""
},
{
"id": "2FEQ",
"database": "PDB",
"url": ""
},
{
"id": "3GIS",
"database": "PDB",
"url": ""
},
{
"id": "1W7G",
"database": "PDB",
"url": ""
},
{
"id": "2CF8",
"database": "PDB",
"url": ""
},
{
"id": "1QHR",
"database": "PDB",
"url": ""
},
{
"id": "5AFY",
"database": "PDB",
"url": ""
},
{
"id": "1TWX",
"database": "PDB",
"url": ""
},
{
"id": "1O0D",
"database": "PDB",
"url": ""
},
{
"id": "1Z8I",
"database": "PDB",
"url": ""
},
{
"id": "1YPG",
"database": "PDB",
"url": ""
},
{
"id": "1HXF",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000180210",
"database": "OpenTargets",
"url": ""
},
{
"id": "1B7X",
"database": "PDB",
"url": ""
},
{
"id": "1DOJ",
"database": "PDB",
"url": ""
},
{
"id": "3EQ0",
"database": "PDB",
"url": ""
},
{
"id": "1VR1",
"database": "PDB",
"url": ""
},
{
"id": "3HKJ",
"database": "PDB",
"url": ""
},
{
"id": "3RM2",
"database": "PDB",
"url": ""
},
{
"id": "1GHY",
"database": "PDB",
"url": ""
},
{
"id": "4DII",
"database": "PDB",
"url": ""
},
{
"id": "1O2G",
"database": "PDB",
"url": ""
},
{
"id": "2ANK",
"database": "PDB",
"url": ""
},
{
"id": "2ZHE",
"database": "PDB",
"url": ""
},
{
"id": "2JH0",
"database": "PDB",
"url": ""
},
{
"id": "3S7K",
"database": "PDB",
"url": ""
},
{
"id": "1AY6",
"database": "PDB",
"url": ""
},
{
"id": "1NU7",
"database": "PDB",
"url": ""
},
{
"id": "1SG8",
"database": "PDB",
"url": ""
},
{
"id": "1A4W",
"database": "PDB",
"url": ""
},
{
"id": "2ZFF",
"database": "PDB",
"url": ""
},
{
"id": "P00734",
"database": "ZINC target",
"url": ""
},
{
"id": "3B9F",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000308541",
"database": "Ensembl",
"url": ""
},
{
"id": "1EOJ",
"database": "PDB",
"url": ""
},
{
"id": "THRB_HUMAN",
"database": "ZINC - FDA approved",
"url": ""
},
{
"id": "4UFG",
"database": "PDB",
"url": ""
},
{
"id": "1JOU",
"database": "PDB",
"url": ""
},
{
"id": "3P70",
"database": "PDB",
"url": ""
},
{
"id": "2BXT",
"database": "PDB",
"url": ""
},
{
"id": "1SB1",
"database": "PDB",
"url": ""
},
{
"id": "4BAO",
"database": "PDB",
"url": ""
},
{
"id": "5AHG",
"database": "PDB",
"url": ""
},
{
"id": "1OOK",
"database": "PDB",
"url": ""
},
{
"id": "3QGN",
"database": "PDB",
"url": ""
},
{
"id": "3RMM",
"database": "PDB",
"url": ""
},
{
"id": "2ANM",
"database": "PDB",
"url": ""
},
{
"id": "2GP9",
"database": "PDB",
"url": ""
},
{
"id": "1YPM",
"database": "PDB",
"url": ""
},
{
"id": "1BTH",
"database": "PDB",
"url": ""
},
{
"id": "3RLW",
"database": "PDB",
"url": ""
},
{
"id": "1GHW",
"database": "PDB",
"url": ""
},
{
"id": "1TBZ",
"database": "PDB",
"url": ""
},
{
"id": "1DWD",
"database": "PDB",
"url": ""
},
{
"id": "1C4Y",
"database": "PDB",
"url": ""
},
{
"id": "1VZQ",
"database": "PDB",
"url": ""
},
{
"id": "3JZ1",
"database": "PDB",
"url": ""
},
{
"id": "2ZF0",
"database": "PDB",
"url": ""
},
{
"id": "2A2X",
"database": "PDB",
"url": ""
},
{
"id": "2ZI2",
"database": "PDB",
"url": ""
},
{
"id": "2ZC9",
"database": "PDB",
"url": ""
},
{
"id": "1ZGI",
"database": "PDB",
"url": ""
},
{
"id": "4LZ4",
"database": "PDB",
"url": ""
},
{
"id": "3QTV",
"database": "PDB",
"url": ""
},
{
"id": "1NRP",
"database": "PDB",
"url": ""
},
{
"id": "1BA8",
"database": "PDB",
"url": ""
},
{
"id": "3K65",
"database": "PDB",
"url": ""
},
{
"id": "5JFD",
"database": "PDB",
"url": ""
},
{
"id": "4H6S",
"database": "PDB",
"url": ""
},
{
"id": "1C5O",
"database": "PDB",
"url": ""
},
{
"id": "2R2M",
"database": "PDB",
"url": ""
},
{
"id": "1HAH",
"database": "PDB",
"url": ""
},
{
"id": "2ZHW",
"database": "PDB",
"url": ""
},
{
"id": "1NU9",
"database": "PDB",
"url": ""
},
{
"id": "5E8E",
"database": "PDB",
"url": ""
},
{
"id": "4BAQ",
"database": "PDB",
"url": ""
},
{
"id": "1HUT",
"database": "PDB",
"url": ""
},
{
"id": "1NRN",
"database": "PDB",
"url": ""
},
{
"id": "3E6P",
"database": "PDB",
"url": ""
},
{
"id": "1RIW",
"database": "PDB",
"url": ""
},
{
"id": "2ZFR",
"database": "PDB",
"url": ""
},
{
"id": "2A45",
"database": "PDB",
"url": ""
},
{
"id": "3UTU",
"database": "PDB",
"url": ""
},
{
"id": "1DM4",
"database": "PDB",
"url": ""
},
{
"id": "3B23",
"database": "PDB",
"url": ""
},
{
"id": "1C5N",
"database": "PDB",
"url": ""
},
{
"id": "1EOL",
"database": "PDB",
"url": ""
},
{
"id": "4RKJ",
"database": "PDB",
"url": ""
},
{
"id": "THRB_HUMAN",
"database": "ZINC - World Drugs",
"url": ""
},
{
"id": "1IHT",
"database": "PDB",
"url": ""
},
{
"id": "2H9T",
"database": "PDB",
"url": ""
},
{
"id": "5GDS",
"database": "PDB",
"url": ""
},
{
"id": "2CN0",
"database": "PDB",
"url": ""
},
{
"id": "5GIM",
"database": "PDB",
"url": ""
},
{
"id": "2ZIQ",
"database": "PDB",
"url": ""
},
{
"id": "5MJT",
"database": "PDB",
"url": ""
},
{
"id": "1KTS",
"database": "PDB",
"url": ""
},
{
"id": "3PO1",
"database": "PDB",
"url": ""
},
{
"id": "1TMT",
"database": "PDB",
"url": ""
},
{
"id": "3U69",
"database": "PDB",
"url": ""
},
{
"id": "1AE8",
"database": "PDB",
"url": ""
},
{
"id": "4BAN",
"database": "PDB",
"url": ""
},
{
"id": "1HAP",
"database": "PDB",
"url": ""
},
{
"id": "2UUF",
"database": "PDB",
"url": ""
},
{
"id": "1AWH",
"database": "PDB",
"url": ""
},
{
"id": "1NRR",
"database": "PDB",
"url": ""
},
{
"id": "4BAH",
"database": "PDB",
"url": ""
},
{
"id": "1A3E",
"database": "PDB",
"url": ""
},
{
"id": "1QJ1",
"database": "PDB",
"url": ""
},
{
"id": "1D6W",
"database": "PDB",
"url": ""
},
{
"id": "2ZO3",
"database": "PDB",
"url": ""
},
{
"id": "1C4U",
"database": "PDB",
"url": ""
},
{
"id": "3P17",
"database": "PDB",
"url": ""
},
{
"id": "1YPK",
"database": "PDB",
"url": ""
},
{
"id": "4UFF",
"database": "PDB",
"url": ""
},
{
"id": "2UUK",
"database": "PDB",
"url": ""
},
{
"id": "1GHV",
"database": "PDB",
"url": ""
},
{
"id": "3EE0",
"database": "PDB",
"url": ""
},
{
"id": "2ZFQ",
"database": "PDB",
"url": ""
},
{
"id": "4BAK",
"database": "PDB",
"url": ""
},
{
"id": "1A61",
"database": "PDB",
"url": ""
},
{
"id": "3UWJ",
"database": "PDB",
"url": ""
},
{
"id": "3JZ2",
"database": "PDB",
"url": ""
},
{
"id": "1MU6",
"database": "PDB",
"url": ""
},
{
"id": "1C5L",
"database": "PDB",
"url": ""
},
{
"id": "6EO9",
"database": "PDB",
"url": ""
},
{
"id": "NP_000497.1",
"database": "RefSeq",
"url": ""
},
{
"id": "5AF9",
"database": "PDB",
"url": ""
},
{
"id": "2PGQ",
"database": "PDB",
"url": ""
},
{
"id": "1GHX",
"database": "PDB",
"url": ""
},
{
"id": "2ZHF",
"database": "PDB",
"url": ""
},
{
"id": "1E0F",
"database": "PDB",
"url": ""
},
{
"id": "1C1U",
"database": "PDB",
"url": ""
},
{
"id": "1WAY",
"database": "PDB",
"url": ""
},
{
"id": "5MLS",
"database": "PDB",
"url": ""
},
{
"id": "3RM0",
"database": "PDB",
"url": ""
},
{
"id": "3QDZ",
"database": "PDB",
"url": ""
},
{
"id": "1TMU",
"database": "PDB",
"url": ""
},
{
"id": "3T5F",
"database": "PDB",
"url": ""
},
{
"id": "THRB_HUMAN",
"database": "ZINC - Metabolites",
"url": ""
},
{
"id": "4MLF",
"database": "PDB",
"url": ""
},
{
"id": "1IHS",
"database": "PDB",
"url": ""
},
{
"id": "1NO9",
"database": "PDB",
"url": ""
},
{
"id": "2BVS",
"database": "PDB",
"url": ""
},
{
"id": "P00734",
"database": "UniProt",
"url": ""
},
{
"id": "3F68",
"database": "PDB",
"url": ""
},
{
"id": "4RN6",
"database": "PDB",
"url": ""
},
{
"id": "1FPH",
"database": "PDB",
"url": ""
},
{
"id": "1LHC",
"database": "PDB",
"url": ""
},
{
"id": "1H8D",
"database": "PDB",
"url": ""
},
{
"id": "1THP",
"database": "PDB",
"url": ""
},
{
"id": "3U8R",
"database": "PDB",
"url": ""
},
{
"id": "5DO4",
"database": "PDB",
"url": ""
},
{
"id": "2ZGX",
"database": "PDB",
"url": ""
},
{
"id": "1HDT",
"database": "PDB",
"url": ""
},
{
"id": "1LHF",
"database": "PDB",
"url": ""
},
{
"id": "3DUX",
"database": "PDB",
"url": ""
},
{
"id": "2V3H",
"database": "PDB",
"url": ""
},
{
"id": "1TQ7",
"database": "PDB",
"url": ""
},
{
"id": "2A0Q",
"database": "PDB",
"url": ""
},
{
"id": "3U8T",
"database": "PDB",
"url": ""
},
{
"id": "1D4P",
"database": "PDB",
"url": ""
},
{
"id": "4I7Y",
"database": "PDB",
"url": ""
},
{
"id": "5JZY",
"database": "PDB",
"url": ""
},
{
"id": "5Z5W",
"database": "PDB",
"url": ""
},
{
"id": "THRB_HUMAN",
"database": "ZINC - Biogenic",
"url": ""
},
{
"id": "4UEH",
"database": "PDB",
"url": ""
},
{
"id": "3SI4",
"database": "PDB",
"url": ""
},
{
"id": "1HXE",
"database": "PDB",
"url": ""
},
{
"id": "1B5G",
"database": "PDB",
"url": ""
},
{
"id": "4AX9",
"database": "PDB",
"url": ""
},
{
"id": "4BAM",
"database": "PDB",
"url": ""
},
{
"id": "1A3B",
"database": "PDB",
"url": ""
},
{
"id": "3VXE",
"database": "PDB",
"url": ""
},
{
"id": "1DIT",
"database": "PDB",
"url": ""
},
{
"id": "4LOY",
"database": "PDB",
"url": ""
},
{
"id": "5L6N",
"database": "PDB",
"url": ""
},
{
"id": "2GDE",
"database": "PDB",
"url": ""
},
{
"id": "4RKO",
"database": "PDB",
"url": ""
},
{
"id": "3BV9",
"database": "PDB",
"url": ""
},
{
"id": "3QWC",
"database": "PDB",
"url": ""
},
{
"id": "1G30",
"database": "PDB",
"url": ""
},
{
"id": "1BB0",
"database": "PDB",
"url": ""
},
{
"id": "5Z5X",
"database": "PDB",
"url": ""
},
{
"id": "3GIC",
"database": "PDB",
"url": ""
},
{
"id": "4HTC",
"database": "PDB",
"url": ""
},
{
"id": "1D3Q",
"database": "PDB",
"url": ""
},
{
"id": "1LHD",
"database": "PDB",
"url": ""
},
{
"id": "1HAG",
"database": "PDB",
"url": ""
},
{
"id": "1TOM",
"database": "PDB",
"url": ""
},
{
"id": "16013",
"database": "Orphanet",
"url": ""
},
{
"id": "1ABJ",
"database": "PDB",
"url": ""
},
{
"id": "4BOH",
"database": "PDB",
"url": ""
},
{
"id": "3QTO",
"database": "PDB",
"url": ""
},
{
"id": "3SHA",
"database": "PDB",
"url": ""
},
{
"id": "1AIX",
"database": "PDB",
"url": ""
},
{
"id": "3VXF",
"database": "PDB",
"url": ""
},
{
"id": "1SL3",
"database": "PDB",
"url": ""
},
{
"id": "3DHK",
"database": "PDB",
"url": ""
},
{
"id": "2ZFP",
"database": "PDB",
"url": ""
},
{
"id": "1HAO",
"database": "PDB",
"url": ""
},
{
"id": "2THF",
"database": "PDB",
"url": ""
},
{
"id": "5EDM",
"database": "PDB",
"url": ""
},
{
"id": "6EO8",
"database": "PDB",
"url": ""
},
{
"id": "3BIU",
"database": "PDB",
"url": ""
},
{
"id": "3C27",
"database": "PDB",
"url": ""
},
{
"id": "1JWT",
"database": "PDB",
"url": ""
},
{
"id": "2HNT",
"database": "PDB",
"url": ""
},
{
"id": "1THS",
"database": "PDB",
"url": ""
},
{
"id": "2FES",
"database": "PDB",
"url": ""
},
{
"id": "5JDU",
"database": "PDB",
"url": ""
},
{
"id": "2ZNK",
"database": "PDB",
"url": ""
},
{
"id": "2C90",
"database": "PDB",
"url": ""
},
{
"id": "1QBV",
"database": "PDB",
"url": ""
},
{
"id": "3D49",
"database": "PDB",
"url": ""
},
{
"id": "1UMA",
"database": "PDB",
"url": ""
},
{
"id": "3SV2",
"database": "PDB",
"url": ""
},
{
"id": "4UDW",
"database": "PDB",
"url": ""
},
{
"id": "1YPJ",
"database": "PDB",
"url": ""
},
{
"id": "2OD3",
"database": "PDB",
"url": ""
},
{
"id": "1NM6",
"database": "PDB",
"url": ""
},
{
"id": "2BVX",
"database": "PDB",
"url": ""
},
{
"id": "1DWC",
"database": "PDB",
"url": ""
},
{
"id": "1BMM",
"database": "PDB",
"url": ""
},
{
"id": "1UVS",
"database": "PDB",
"url": ""
},
{
"id": "1CA8",
"database": "PDB",
"url": ""
},
{
"id": "2PKS",
"database": "PDB",
"url": ""
},
{
"id": "1GJ5",
"database": "PDB",
"url": ""
},
{
"id": "4DIH",
"database": "PDB",
"url": ""
},
{
"id": "2ZDA",
"database": "PDB",
"url": ""
},
{
"id": "3DT0",
"database": "PDB",
"url": ""
},
{
"id": "2ZGB",
"database": "PDB",
"url": ""
},
{
"id": "1HBT",
"database": "PDB",
"url": ""
},
{
"id": "1MUE",
"database": "PDB",
"url": ""
},
{
"id": "2BDY",
"database": "PDB",
"url": ""
},
{
"id": "3SQE",
"database": "PDB",
"url": ""
},
{
"id": "1SGI",
"database": "PDB",
"url": ""
},
{
"id": "THRB_HUMAN",
"database": "ZINC - Investigational",
"url": ""
},
{
"id": "1QJ6",
"database": "PDB",
"url": ""
},
{
"id": "2C93",
"database": "PDB",
"url": ""
},
{
"id": "4LXB",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000180210",
"database": "Ensembl",
"url": ""
},
{
"id": "3NXP",
"database": "PDB",
"url": ""
},
{
"id": "4O03",
"database": "PDB",
"url": ""
},
{
"id": "1ZGV",
"database": "PDB",
"url": ""
},
{
"id": "1JMO",
"database": "PDB",
"url": ""
},
{
"id": "6V5T",
"database": "PDB",
"url": ""
},
{
"id": "1BHX",
"database": "PDB",
"url": ""
},
{
"id": "4AYV",
"database": "PDB",
"url": ""
},
{
"id": "1SHH",
"database": "PDB",
"url": ""
},
{
"id": "1A5G",
"database": "PDB",
"url": ""
},
{
"id": "1OYT",
"database": "PDB",
"url": ""
},
{
"id": "1HAI",
"database": "PDB",
"url": ""
},
{
"id": "1MH0",
"database": "PDB",
"url": ""
},
{
"id": "1AHT",
"database": "PDB",
"url": ""
},
{
"id": "1FPC",
"database": "PDB",
"url": ""
},
{
"id": "1Z71",
"database": "PDB",
"url": ""
},
{
"id": "4YES",
"database": "PDB",
"url": ""
},
{
"id": "3QX5",
"database": "PDB",
"url": ""
},
{
"id": "3PMH",
"database": "PDB",
"url": ""
},
{
"id": "4CH2",
"database": "PDB",
"url": ""
},
{
"id": "1DX5",
"database": "PDB",
"url": ""
},
{
"id": "1C4V",
"database": "PDB",
"url": ""
},
{
"id": "4HFP",
"database": "PDB",
"url": ""
},
{
"id": "1D9I",
"database": "PDB",
"url": ""
},
{
"id": "3U98",
"database": "PDB",
"url": ""
},
{
"id": "P00734",
"database": "GeneCards",
"url": ""
},
{
"id": "4E06",
"database": "PDB",
"url": ""
},
{
"id": "1NZQ",
"database": "PDB",
"url": ""
},
{
"id": "4UFD",
"database": "PDB",
"url": ""
},
{
"id": "3BEF",
"database": "PDB",
"url": ""
},
{
"id": "2362",
"database": "Guide to Pharmacology - Targets",
"url": ""
},
{
"id": "3SI3",
"database": "PDB",
"url": ""
},
{
"id": "5EW2",
"database": "PDB",
"url": ""
},
{
"id": "1DWB",
"database": "PDB",
"url": ""
},
{
"id": "P00734",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "4E7R",
"database": "PDB",
"url": ""
},
{
"id": "2C8Z",
"database": "PDB",
"url": ""
},
{
"id": "3RML",
"database": "PDB",
"url": ""
},
{
"id": "1GJ4",
"database": "PDB",
"url": ""
},
{
"id": "1TQ0",
"database": "PDB",
"url": ""
},
{
"id": "3TU7",
"database": "PDB",
"url": ""
},
{
"id": "1ABI",
"database": "PDB",
"url": ""
},
{
"id": "HMDBP13521",
"database": "HMDB Protein",
"url": ""
},
{
"id": "2JH6",
"database": "PDB",
"url": ""
},
{
"id": "1MU8",
"database": "PDB",
"url": ""
},
{
"id": "5EW1",
"database": "PDB",
"url": ""
},
{
"id": "3SQH",
"database": "PDB",
"url": ""
},
{
"id": "4AYY",
"database": "PDB",
"url": ""
},
{
"id": "3DA9",
"database": "PDB",
"url": ""
},
{
"id": "3U9A",
"database": "PDB",
"url": ""
},
{
"id": "2CF9",
"database": "PDB",
"url": ""
},
{
"id": "4LZ1",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000311907",
"database": "Ensembl",
"url": ""
},
{
"id": "6C2W",
"database": "PDB",
"url": ""
},
{
"id": "NP_001298186.1",
"database": "RefSeq",
"url": ""
},
{
"id": "3C1K",
"database": "PDB",
"url": ""
},
{
"id": "2PGB",
"database": "PDB",
"url": ""
},
{
"id": "7KME",
"database": "PDB",
"url": ""
},
{
"id": "1BCU",
"database": "PDB",
"url": ""
},
{
"id": "3LDX",
"database": "PDB",
"url": ""
},
{
"id": "5A2M",
"database": "PDB",
"url": ""
},
{
"id": "3BEI",
"database": "PDB",
"url": ""
},
{
"id": "6EO7",
"database": "PDB",
"url": ""
},
{
"id": "1K22",
"database": "PDB",
"url": ""
},
{
"id": "7TPP",
"database": "PDB",
"url": ""
},
{
"id": "1THR",
"database": "PDB",
"url": ""
},
{
"id": "1QUR",
"database": "PDB",
"url": ""
},
{
"id": "1A2C",
"database": "PDB",
"url": ""
},
{
"id": "1T4U",
"database": "PDB",
"url": ""
},
{
"id": "1DE7",
"database": "PDB",
"url": ""
},
{
"id": "3RMO",
"database": "PDB",
"url": ""
},
{
"id": "2C8Y",
"database": "PDB",
"url": ""
},
{
"id": "1NY2",
"database": "PDB",
"url": ""
},
{
"id": "4DY7",
"database": "PDB",
"url": ""
},
{
"id": "1H8I",
"database": "PDB",
"url": ""
},
{
"id": "2PW8",
"database": "PDB",
"url": ""
},
{
"id": "3HTC",
"database": "PDB",
"url": ""
},
{
"id": "THRB_HUMAN",
"database": "ZINC - Predictions - Purchasable",
"url": ""
},
{
"id": "2C8W",
"database": "PDB",
"url": ""
},
{
"id": "3LU9",
"database": "PDB",
"url": ""
},
{
"id": "1TB6",
"database": "PDB",
"url": ""
},
{
"id": "4UD9",
"database": "PDB",
"url": ""
},
{
"id": "2UUJ",
"database": "PDB",
"url": ""
},
{
"id": "2JH5",
"database": "PDB",
"url": ""
},
{
"id": "2B5T",
"database": "PDB",
"url": ""
},
{
"id": "1RD3",
"database": "PDB",
"url": ""
},
{
"id": "1TA2",
"database": "PDB",
"url": ""
},
{
"id": "1AD8",
"database": "PDB",
"url": ""
},
{
"id": "1O5G",
"database": "PDB",
"url": ""
},
{
"id": "3QLP",
"database": "PDB",
"url": ""
},
{
"id": "3S7H",
"database": "PDB",
"url": ""
},
{
"id": "5EDK",
"database": "PDB",
"url": ""
},
{
"id": "1D3P",
"database": "PDB",
"url": ""
},
{
"id": "4H6T",
"database": "PDB",
"url": ""
},
{
"id": "1BMN",
"database": "PDB",
"url": ""
},
{
"id": "1KTT",
"database": "PDB",
"url": ""
},
{
"id": "THRB_HUMAN",
"database": "ZINC - Substances",
"url": ""
},
{
"id": "2ZHQ",
"database": "PDB",
"url": ""
},
{
"id": "6EO6",
"database": "PDB",
"url": ""
},
{
"id": "1C1W",
"database": "PDB",
"url": ""
},
{
"id": "1WBG",
"database": "PDB",
"url": ""
},
{
"id": "5MM6",
"database": "PDB",
"url": ""
},
{
"id": "1PPB",
"database": "PDB",
"url": ""
},
{
"id": "3DD2",
"database": "PDB",
"url": ""
},
{
"id": "4AZ2",
"database": "PDB",
"url": ""
},
{
"id": "1NT1",
"database": "PDB",
"url": ""
},
{
"id": "4UE7",
"database": "PDB",
"url": ""
},
{
"id": "4NZQ",
"database": "PDB",
"url": ""
},
{
"id": "2HGT",
"database": "PDB",
"url": ""
},
{
"id": "2BVR",
"database": "PDB",
"url": ""
},
{
"id": "1NRO",
"database": "PDB",
"url": ""
}
]
},
{
"participant_id": "R-HSA-156786",
"participant_name": "activated thrombin (factor IIa) [extracellular region]",
"crossref": [
{
"id": "CPX-6222",
"database": "ComplexPortal",
"url": ""
}
]
}
],
"reaction_enzymes": [
{
"uniprot_ac": "P00734",
"gene_name": "F2",
"activity": [
{
"ec_number": "3.4.21.5",
"activity": "Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.",
"evidence": [
{
"id": "P00734",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00734"
}
]
},
{
"ec_number": "3.4.21.5",
"activity": "",
"evidence": [
{
"id": "P00734",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00734"
}
]
}
]
},
{
"uniprot_ac": "P00740",
"gene_name": "F9",
"activity": [
{
"ec_number": "3.4.21.22",
"activity": "Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.",
"evidence": [
{
"id": "P00740",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00740"
}
]
},
{
"ec_number": "3.4.21.22",
"activity": "",
"evidence": [
{
"id": "P00740",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00740"
}
]
}
]
},
{
"uniprot_ac": "P00742",
"gene_name": "F10",
"activity": [
{
"ec_number": "3.4.21.6",
"activity": "Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.",
"evidence": [
{
"id": "P00742",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00742"
}
]
},
{
"ec_number": "3.4.21.6",
"activity": "",
"evidence": [
{
"id": "P00742",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00742"
}
]
}
]
},
{
"uniprot_ac": "P08709",
"gene_name": "F7",
"activity": [
{
"ec_number": "3.4.21.21",
"activity": "Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.",
"evidence": [
{
"id": "P08709",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08709"
}
]
},
{
"ec_number": "3.4.21.21",
"activity": "",
"evidence": [
{
"id": "P08709",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08709"
}
]
}
]
},
{
"uniprot_ac": "P09958",
"gene_name": "FURIN",
"activity": [
{
"ec_number": "3.4.21.75",
"activity": "Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.",
"evidence": [
{
"id": "P09958",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09958"
}
]
},
{
"ec_number": "3.4.21.75",
"activity": "",
"evidence": [
{
"id": "P09958",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09958"
}
]
}
]
},
{
"uniprot_ac": "P38435",
"gene_name": "GGCX",
"activity": [
{
"ec_number": "4.1.1.90",
"activity": "2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O = CO2 + L-glutamyl-[protein] + O2 + phylloquinol.",
"evidence": [
{
"id": "P38435",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38435"
}
]
},
{
"ec_number": "4.1.1.90",
"activity": "",
"evidence": [
{
"id": "P38435",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38435"
}
]
}
]
}
],
"biomarkers": [],
"synthesized_glycans": [],
"cluster_types": [
{
"name": "isoformset.uniprotkb",
"label": "Isoforms"
},
{
"name": "homologset.mgi",
"label": "MGI Homologs"
}
],
"sequence_features": {
"n_linked_sites": [
221,
231
],
"o_linked_sites": [
188,
189,
190,
197,
199,
203,
211,
476,
483,
484,
485
],
"snv_sites": [
75,
80,
117,
190,
199,
221,
223,
231,
339,
358,
428,
463,
476,
483
],
"glycation_sites": [],
"phosphorylation_sites": [],
"sequon_annotation_sites": [
{
"start_pos": 221,
"end_pos": 223
},
{
"start_pos": 231,
"end_pos": 233
}
]
},
"section_stats": [
{
"table_id": "glycosylation",
"table_stats": [
{
"field": "total",
"count": 72
},
{
"field": "total_sites",
"count": 14
},
{
"field": "n_linked_glycans",
"count": 26
},
{
"field": "n_linked_glycan_sites",
"count": 4
},
{
"field": "o_linked_glycans",
"count": 6
},
{
"field": "o_linked_glycan_sites",
"count": 13
}
],
"sort_fields": [
"glytoucan_ac",
"type",
"subtype",
"site_category",
"site_seq",
"relation",
"comment",
"start_pos",
"start_aa",
"end_pos",
"end_aa",
"residue",
"site_lbl"
]
},
{
"table_id": "glycosylation_reported",
"table_stats": [
{
"field": "total",
"count": 4
},
{
"field": "total_sites",
"count": 4
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 2
},
{
"field": "o_linked_glycans",
"count": 0
},
{
"field": "o_linked_glycan_sites",
"count": 2
}
],
"sort_fields": [
"glytoucan_ac",
"type",
"subtype",
"site_category",
"site_seq",
"relation",
"comment",
"start_pos",
"start_aa",
"end_pos",
"end_aa",
"residue",
"site_lbl"
]
},
{
"table_id": "glycosylation_reported_with_glycan",
"table_stats": [
{
"field": "total",
"count": 68
},
{
"field": "total_sites",
"count": 13
},
{
"field": "n_linked_glycans",
"count": 26
},
{
"field": "n_linked_glycan_sites",
"count": 2
},
{
"field": "o_linked_glycans",
"count": 6
},
{
"field": "o_linked_glycan_sites",
"count": 11
}
],
"sort_fields": [
"glytoucan_ac",
"type",
"subtype",
"site_category",
"site_seq",
"relation",
"comment",
"start_pos",
"start_aa",
"end_pos",
"end_aa",
"residue",
"site_lbl"
]
},
{
"table_id": "glycosylation_predicted",
"table_stats": [
{
"field": "total",
"count": 0
},
{
"field": "total_sites",
"count": 0
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 0
},
{
"field": "o_linked_glycans",
"count": 0
},
{
"field": "o_linked_glycan_sites",
"count": 0
}
],
"sort_fields": []
},
{
"table_id": "glycosylation_automatic_literature_mining",
"table_stats": [
{
"field": "total",
"count": 0
},
{
"field": "total_sites",
"count": 0
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 0
},
{
"field": "o_linked_glycans",
"count": 0
},
{
"field": "o_linked_glycan_sites",
"count": 0
}
],
"sort_fields": []
},
{
"table_id": "phosphorylation",
"table_stats": [
{
"field": "total",
"count": 0
},
{
"field": "total_sites",
"count": 0
}
],
"sort_fields": []
},
{
"table_id": "snv",
"table_stats": [
{
"field": "total",
"count": 18
},
{
"field": "total_sites",
"count": 14
}
],
"sort_fields": [
"start_pos",
"end_pos",
"subjects_tested",
"subjects_positive",
"frequency",
"sequence_org",
"sequence_mut",
"comment",
"chr_id",
"chr_pos",
"ref_nt",
"alt_nt",
"minor_allelic_frequency",
"site_lbl"
]
},
{
"table_id": "snv_disease",
"table_stats": [
{
"field": "total",
"count": 10
},
{
"field": "total_sites",
"count": 9
}
],
"sort_fields": [
"start_pos",
"end_pos",
"subjects_tested",
"subjects_positive",
"frequency",
"sequence_org",
"sequence_mut",
"comment",
"chr_id",
"chr_pos",
"ref_nt",
"alt_nt",
"minor_allelic_frequency",
"site_lbl"
]
},
{
"table_id": "snv_non_disease",
"table_stats": [
{
"field": "total",
"count": 8
},
{
"field": "total_sites",
"count": 6
}
],
"sort_fields": [
"start_pos",
"end_pos",
"subjects_tested",
"subjects_positive",
"frequency",
"sequence_org",
"sequence_mut",
"comment",
"chr_id",
"chr_pos",
"ref_nt",
"alt_nt",
"minor_allelic_frequency",
"site_lbl"
]
},
{
"table_id": "publication",
"table_stats": [
{
"field": "total",
"count": 181
}
],
"sort_fields": [
"title",
"journal",
"date",
"authors"
]
}
]
}