{ "uniprot_canonical_ac": "O96923-1", "uniprot_ac": "O96923", "uniprot_id": "GNRA_DICDI", "mass": { "chemical_mass": 124778.0, "monoisotopic_mass": 124778.0 }, "refseq": { "ac": "XP_635347", "name": "gelsolin-related protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_635347" }, "gene_names": [ { "name": "gnrA", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O96923", "id": "O96923" }, { "name": "DDB_G0291125", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O96923", "id": "O96923" }, { "name": "gnrA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_635347", "id": "XP_635347" } ], "protein_names": [ { "name": "Gelsolin-related protein of 125 kDa", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O96923" }, { "name": "GRP125", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O96923" }, { "name": "gelsolin-related protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_635347", "id": "XP_635347" } ], "function": [ { "annotation": "Involved in phototaxis. Required for coupling photodetection to the locomotory machinery of slugs. May be essential in the natural environment for the propagation of spores.", "evidence": [ { "database": "UniProtKB", "id": "O96923", "url": "https://www.uniprot.org/uniprot/O96923#function" }, { "database": "PubMed", "id": "9880334", "url": "https://glygen.org/publication/PubMed/9880334" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "O96923", "url": "https://www.uniprot.org/uniprot/O96923" } ], "common_name": "Cellular slime molds" } ], "gene": [ { "name": "gnrA", "url": "https://www.uniprot.org/uniprot/O96923", "locus": {} } ], "crossref": [ { "id": "cd11288", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11288", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11289", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11289", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11291", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11291", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11292", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11292", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "DDB_G0291125", "url": "http://dictybase.org/gene/DDB_G0291125", "database": "dictyBase", "categories": [ "Organism-specific" ] }, { "id": "8627995", "url": "https://www.ncbi.nlm.nih.gov/gene/8627995", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007122", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007122", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007123", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007123", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029006", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029006", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0291125", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0291125", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FILDCEH", "url": "https://omabrowser.org/oma/group/FILDCEH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11977", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11977", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11977:SF129", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11977:SF129", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00626", "url": "http://pfam.xfam.org/family/PF00626", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_O96923", "url": "http://purl.obolibrary.org/obo/PR_O96923", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DDI-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6798695", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_635347", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_635347", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "O96923", "url": "https://www.uniprot.org/uniprot/O96923", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O96923-1", "url": "https://www.uniprot.org/uniprot/O96923-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEDNIVDSKEIENNVEDKKEETPSSSPSPSSSLQQQQEEGGVVKQAVSNLVSSSITLHDDAKLIQVTGKDEPFHFISVPMSVEFLNLEDVFIMQSDAYIFVWCSEQANIKKKAKAVQMAQKLKVEIGCQRAVQVLEIGEEHPTFLFCLGVPKGTKLNVTKEKNDIFQVDEDDEEQVLEPEFFLFKIFTGTDGKPSIKPMEEDEGINQEMLESSACFILDCEHEMYIWLGKGVKKSTKDTLIPVAKKIWTQYDRPEYYGKLKLQPIITWVFDGAESCLFKSKFSKWVEKAQPLQTSYLSLSSKKKEALNFDVSSMHQDKEVPVINIGAASDYSNGKLLVWCSGGGSGNKWNKVEEDDFGIFYSNKSYVCHFIYKPENKNSIRSVIFFWEGLYSNQRNYIGYKFGLYKEIQKKMEGLKSDDPVEYRISQNKEPQEFINLFGTELLVLNEELALKPMIFQVRANRGTQLFPDPDSCNAKLLNSLDSFVFLFPNKYIIVWHGKVSTEHQRELAADLFTFLPPEYEAGVKEFDQGKESDNFWKIIGGNSNDIVINTFINENKEEKEKEEEEKEEEEEEEEEEEEEEEEEKDNNKTTTIIKHLRPKKIKLFLCTDNSGIFKADQINPFSQVDLNSQECVLLDVYHKVFLWKGSKSTDQKLNDTQDLAKQYIETANDQRPSDCSVELVEQYNESPLFKSYFHSWKVTPPKVFIDPIISYKQKLAERLQKEKEDLEKLKQQQEQEQEQQQKENNKIVEEVKEEVKEEDVKEEVKEEEVKEEEVKEEEVKEVAKEETKEEIKEEVNDEATEVKEVNQVEEEVKEEEVKEEVKVEVKEEEVKGEAKEEEVKEEEVKEEEVKEEVKEVKEEVKEEVKQDKEEEVNEEIKEETKEEETKEDDNKEDEKVNEENETVNEENEVGIIVSPPSEKVDEANSSSTISSPENEGSVSVKDKRKSNEPITPSVVSSSGDLLFAYEPYHGPPIHSSNSPKQGRKGGRKSHGKNQPQHKKNHSVDQSPLSSPIIPNKSLNLDIDNQSFDLNSINNNNSVEVLDGASSPLSFSSSSINSNSTHNTPSKKNKNKNKKKHNRSSSLTHA", "length": 1087, "header": "sp|O96923-1|GNRA_DICDI Isoform 1 of Gelsolin-related protein of 125 kDa OS=Dictyostelium discoideum OX=44689 GN=gnrA PE=1 SV=1 CANONICAL=O96923-1" }, "isoforms": [ { "isoform_ac": "O96923-1", "url": "", "sequence": { "sequence": "MEEDNIVDSKEIENNVEDKKEETPSSSPSPSSSLQQQQEEGGVVKQAVSNLVSSSITLHDDAKLIQVTGKDEPFHFISVPMSVEFLNLEDVFIMQSDAYIFVWCSEQANIKKKAKAVQMAQKLKVEIGCQRAVQVLEIGEEHPTFLFCLGVPKGTKLNVTKEKNDIFQVDEDDEEQVLEPEFFLFKIFTGTDGKPSIKPMEEDEGINQEMLESSACFILDCEHEMYIWLGKGVKKSTKDTLIPVAKKIWTQYDRPEYYGKLKLQPIITWVFDGAESCLFKSKFSKWVEKAQPLQTSYLSLSSKKKEALNFDVSSMHQDKEVPVINIGAASDYSNGKLLVWCSGGGSGNKWNKVEEDDFGIFYSNKSYVCHFIYKPENKNSIRSVIFFWEGLYSNQRNYIGYKFGLYKEIQKKMEGLKSDDPVEYRISQNKEPQEFINLFGTELLVLNEELALKPMIFQVRANRGTQLFPDPDSCNAKLLNSLDSFVFLFPNKYIIVWHGKVSTEHQRELAADLFTFLPPEYEAGVKEFDQGKESDNFWKIIGGNSNDIVINTFINENKEEKEKEEEEKEEEEEEEEEEEEEEEEEKDNNKTTTIIKHLRPKKIKLFLCTDNSGIFKADQINPFSQVDLNSQECVLLDVYHKVFLWKGSKSTDQKLNDTQDLAKQYIETANDQRPSDCSVELVEQYNESPLFKSYFHSWKVTPPKVFIDPIISYKQKLAERLQKEKEDLEKLKQQQEQEQEQQQKENNKIVEEVKEEVKEEDVKEEVKEEEVKEEEVKEEEVKEVAKEETKEEIKEEVNDEATEVKEVNQVEEEVKEEEVKEEVKVEVKEEEVKGEAKEEEVKEEEVKEEEVKEEVKEVKEEVKEEVKQDKEEEVNEEIKEETKEEETKEDDNKEDEKVNEENETVNEENEVGIIVSPPSEKVDEANSSSTISSPENEGSVSVKDKRKSNEPITPSVVSSSGDLLFAYEPYHGPPIHSSNSPKQGRKGGRKSHGKNQPQHKKNHSVDQSPLSSPIIPNKSLNLDIDNQSFDLNSINNNNSVEVLDGASSPLSFSSSSINSNSTHNTPSKKNKNKNKKKHNRSSSLTHA", "length": 1087, "header": "sp|O96923-1|GNRA_DICDI Isoform 1 of Gelsolin-related protein of 125 kDa OS=Dictyostelium discoideum OX=44689 GN=gnrA PE=1 SV=1 CANONICAL=O96923-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Eichinger L, Pachebat J A, Gl\u00f6ckner G, Rajandream M-A, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov B A, Rivero F, Bankier A T, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, Hauser H, James K, Quiles M, Madan Babu M, Saito T, Buchrieser C, Wardroper A, Felder M, Thangavelu M, Johnson D, Knights A, Loulseged H, Mungall K, Oliver K, Price C, Quail M A, Urushihara H, Hernandez J, Rabbinowitsch E, Steffen D, Sanders M, Ma J, Kohara Y, Sharp S, Simmonds M, Spiegler S, Tivey A, Sugano S, White B, Walker D, Woodward J, Winckler T, Tanaka Y, Shaulsky G, Schleicher M, Weinstock G, Rosenthal A, Cox E C, Chisholm R L, Gibbs R, Loomis W F, Platzer M, Kay R R, Williams J, Dear P H, Noegel A A, Barrell B, Kuspa A", "evidence": [ { "database": "UniProtKB", "id": "O96923", "url": "https://www.uniprot.org/uniprot/O96923" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] }, { "title": "A phototaxis signalling complex in Dictyostelium discoideum.", "journal": "Eur. J. Cell Biol.", "date": "2006", "authors": "Bandala-Sanchez Esther, Annesley Sarah J, Fisher Paul R", "evidence": [ { "database": "UniProtKB", "id": "O96923", "url": "https://www.uniprot.org/uniprot/O96923" } ], "reference": [ { "type": "PubMed", "id": "16735078", "url": "https://glygen.org/publication/PubMed/16735078" } ] }, { "title": "Phototactic migration of Dictyostelium cells is linked to a new type of gelsolin-related protein.", "journal": "Molecular biology of the cell", "date": "1999-01", "authors": "Stocker S, Hiery M, Marriott G", "evidence": [ { "database": "UniProtKB", "id": "O96923", "url": "https://www.uniprot.org/uniprot/O96923" } ], "reference": [ { "type": "PubMed", "id": "9880334", "url": "https://glygen.org/publication/PubMed/9880334" } ] } ], "pathway": [ { "id": "ddi:DDB_G0291125", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0291125", "resource": "KEGG Pathway" }, { "id": "R-DDI-6798695", "name": "Neutrophil degranulation", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "phosphatidylinositol-4,5-bisphosphate binding", "id": "GO:0005546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005546", "evidence": [ { "database": "UniProtKB", "id": "O96923", "url": "https://www.uniprot.org/uniprot/O96923" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "O96923", "url": "https://www.uniprot.org/uniprot/O96923" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "O96923", "url": "https://www.uniprot.org/uniprot/O96923" } ], "pmid": "" }, { "name": "filamin binding", "id": "GO:0031005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031005", "evidence": [ { "database": "UniProtKB", "id": "O96923", "url": "https://www.uniprot.org/uniprot/O96923" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O96923", "url": "https://www.uniprot.org/uniprot/O96923" } ], "pmid": "" }, { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "O96923", "url": "https://www.uniprot.org/uniprot/O96923" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "O96923", "url": "https://www.uniprot.org/uniprot/O96923" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "barbed-end actin filament capping", "id": "GO:0051016", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051016", "evidence": [ { "database": "UniProtKB", "id": "O96923", "url": "https://www.uniprot.org/uniprot/O96923" } ], "pmid": "" }, { "name": "actin polymerization or depolymerization", "id": "GO:0008154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008154", "evidence": [ { "database": "UniProtKB", "id": "O96923", "url": "https://www.uniprot.org/uniprot/O96923" } ], "pmid": "" }, { "name": "actin filament severing", "id": "GO:0051014", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051014", "evidence": [ { "database": "UniProtKB", "id": "O96923", "url": "https://www.uniprot.org/uniprot/O96923" } ], "pmid": "" }, { "name": "phototaxis", "id": "GO:0042331", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042331", "evidence": [ { "database": "UniProtKB", "id": "O96923", "url": "https://www.uniprot.org/uniprot/O96923" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1002, "end_pos": 1004, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1017, "end_pos": 1019, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1026, "end_pos": 1028, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1037, "end_pos": 1039, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1060, "end_pos": 1062, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1079, "end_pos": 1081, "annotation": "n_glycosylation_sequon" }, { "start_pos": 158, "end_pos": 160, "annotation": "n_glycosylation_sequon" }, { "start_pos": 364, "end_pos": 366, "annotation": "n_glycosylation_sequon" }, { "start_pos": 589, "end_pos": 591, "annotation": "n_glycosylation_sequon" }, { "start_pos": 656, "end_pos": 658, "annotation": "n_glycosylation_sequon" }, { "start_pos": 686, "end_pos": 688, "annotation": "n_glycosylation_sequon" }, { "start_pos": 902, "end_pos": 904, "annotation": "n_glycosylation_sequon" }, { "start_pos": 926, "end_pos": 928, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1002, "end_pos": 1004 }, { "start_pos": 1017, "end_pos": 1019 }, { "start_pos": 1026, "end_pos": 1028 }, { "start_pos": 1037, "end_pos": 1039 }, { "start_pos": 1060, "end_pos": 1062 }, { "start_pos": 1079, "end_pos": 1081 }, { "start_pos": 158, "end_pos": 160 }, { "start_pos": 364, "end_pos": 366 }, { "start_pos": 589, "end_pos": 591 }, { "start_pos": 656, "end_pos": 658 }, { "start_pos": 686, "end_pos": 688 }, { "start_pos": 902, "end_pos": 904 }, { "start_pos": 926, "end_pos": 928 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }