{ "uniprot_canonical_ac": "O96006-1", "uniprot_ac": "O96006", "uniprot_id": "ZBED1_HUMAN", "mass": { "chemical_mass": 78156.0, "monoisotopic_mass": 78156.0 }, "refseq": { "ac": "NP_001164606", "name": "E3 SUMO-protein ligase ZBED1", "summary": "This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It was earlier identified as a gene with similarity to Ac transposable elements, however, was found not to have transposase activity. Later studies show that this gene product is localized in the nucleus and functions as a transcription factor. It binds to DNA elements found in the promoter regions of several genes related to cell proliferation, such as histone H1, hence may have a role in regulating genes related to cell proliferation. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene. [provided by RefSeq, Jan 2010].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164606" }, "gene_names": [ { "name": "ZBED1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O96006", "id": "O96006" }, { "name": "ALTE; DREF; hDREF; TRAMP", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164606", "id": "NP_001164606" }, { "name": "ALTE", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O96006", "id": "O96006" }, { "name": "DREF", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O96006", "id": "O96006" }, { "name": "KIAA0785", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O96006", "id": "O96006" }, { "name": "TRAMP", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O96006", "id": "O96006" }, { "name": "ZBED1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164606", "id": "NP_001164606" }, { "name": "hDREF", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O96006", "id": "O96006" } ], "protein_names": [ { "name": "E3 SUMO-protein ligase ZBED1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O96006" }, { "name": "2.3.2.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O96006" }, { "name": "DNA replication-related element binding factor; Ac-like transposable element; zinc finger BED domain-containing protein 1; BED-type zinc finger domain-containing protein 1; dREF homolog", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164606", "id": "NP_001164606" }, { "name": "DNA replication-related element-binding factor", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O96006" }, { "name": "E3 SUMO-protein ligase ZBED1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164606", "id": "NP_001164606" }, { "name": "Putative Ac-like transposable element", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O96006" }, { "name": "Zinc finger BED domain-containing protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O96006" }, { "name": "dREF homolog", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O96006" } ], "function": [ { "annotation": "(Microbial infection) Binds to human adenovirus gene promoters and contributes to transcriptional repression and virus growth inhibition during early stages of infection.", "evidence": [ { "database": "UniProtKB", "id": "O96006", "url": "https://www.uniprot.org/uniprot/O96006#function" }, { "database": "PubMed", "id": "25210186", "url": "https://glygen.org/publication/PubMed/25210186" } ] }, { "annotation": "Expression of hDREF/KIAA0785 may have a role in regulation of human genes related to cell proliferation", "evidence": [ { "database": "RefSeq", "id": "NP_001164606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164606" }, { "database": "PubMed", "id": "12663651", "url": "https://glygen.org/publication/PubMed/12663651" } ] }, { "annotation": "Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA (PubMed:27068747). This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12 (PubMed:12663651, PubMed:17209048, PubMed:17220279, PubMed:27068747). The resulting increased transcriptional activity drives cell proliferation (PubMed:12663651, PubMed:17220279). Binds to 5'-TGTCG[CT]GA[CT]A-3' consensus sequences in gene promoters of ribosomal proteins (PubMed:12663651, PubMed:17209048, PubMed:17220279, PubMed:27068747).", "evidence": [ { "database": "UniProtKB", "id": "O96006", "url": "https://www.uniprot.org/uniprot/O96006#function" }, { "database": "PubMed", "id": "17209048", "url": "https://glygen.org/publication/PubMed/17209048" }, { "database": "PubMed", "id": "27068747", "url": "https://glygen.org/publication/PubMed/27068747" }, { "database": "PubMed", "id": "12663651", "url": "https://glygen.org/publication/PubMed/12663651" }, { "database": "PubMed", "id": "17220279", "url": "https://glygen.org/publication/PubMed/17220279" } ] }, { "annotation": "HDREF is an important transcription factor for cell proliferation which plays roles in cell cycle-dependent regulation of a number of ribosomal protein genes", "evidence": [ { "database": "RefSeq", "id": "NP_001164606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164606" }, { "database": "PubMed", "id": "17220279", "url": "https://glygen.org/publication/PubMed/17220279" } ] }, { "annotation": "Self-association of hDREF via the hATC domain is necessary for its nuclear accumulation and DNA binding.", "evidence": [ { "database": "RefSeq", "id": "NP_001164606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164606" }, { "database": "PubMed", "id": "17209048", "url": "https://glygen.org/publication/PubMed/17209048" } ] }, { "annotation": "This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It was earlier identified as a gene with similarity to Ac transposable elements, however, was found not to have transposase activity. Later studies show that this gene product is localized in the nucleus and functions as a transcription factor. It binds to DNA elements found in the promoter regions of several genes related to cell proliferation, such as histone H1, hence may have a role in regulating genes related to cell proliferation. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene. [provided by RefSeq, Jan 2010].", "evidence": [ { "database": "RefSeq", "id": "NP_001164606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164606" } ] }, { "annotation": "ZBED1 Regulates Genes Important for Multiple Biological Processes of the Placenta. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001164606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164606" }, { "database": "PubMed", "id": "35052473", "url": "https://glygen.org/publication/PubMed/35052473" } ] }, { "annotation": "ZBED1 is not a cell proliferation-associated factor such as Drosophila DREF, and our study adds to the cumulative understanding of the functions of ZBED1 in human cells and tissues. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001164606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164606" }, { "database": "PubMed", "id": "30304065", "url": "https://glygen.org/publication/PubMed/30304065" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "O96006", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O96006" } ], "glycoeffect": [], "start_pos": 21, "end_pos": 21, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "A", "sequence_mut": "T", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "X", "chr_pos": "2490659", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "A21", "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. 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"database": "Bgee", "id": "ENSG00000214717", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000214717" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "86.1", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000214717", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000214717" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "85.98", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000214717", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000214717" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "89.07", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000214717", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000214717" } ] 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], "reference": [ { "type": "PubMed", "id": "14578449", "url": "https://glygen.org/publication/PubMed/14578449" } ] }, { "title": "SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression.", "journal": "Genes & development", "date": "2003", "authors": "Dobreva G, Dambacher J, Grosschedl R", "evidence": [ { "database": "Reactome", "id": "R-HSA-4551638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4551638" } ], "reference": [ { "type": "PubMed", "id": "14701874", "url": "https://glygen.org/publication/PubMed/14701874" } ] }, { "title": "SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1.", "journal": "Molecular and cellular biology", "date": "2004", "authors": "Cheng J, Wang D, Wang Z, Yeh ET", "evidence": [ { "database": "Reactome", "id": "R-HSA-4551638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4551638" } ], "reference": [ { "type": "PubMed", "id": "15199155", "url": "https://glygen.org/publication/PubMed/15199155" } ] }, { "title": "Multiple activities contribute to Pc2 E3 function.", "journal": "The EMBO journal", "date": "2005", "authors": "Kagey MH, Melhuish TA, Powers SE, Wotton D", "evidence": [ { "database": "Reactome", "id": "R-HSA-4551638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4551638" } ], "reference": [ { "type": "PubMed", "id": "15592428", "url": "https://glygen.org/publication/PubMed/15592428" } ] }, { "title": "Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2.", "journal": "Molecular cell", "date": "2006", "authors": "Roscic A, Moller A, Calzado MA, Renner F, Wimmer VC, Gresko E, Ludi KS, Schmitz ML", "evidence": [ { "database": "Reactome", "id": "R-HSA-4551638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4551638" } ], "reference": [ { "type": "PubMed", "id": "17018294", "url": "https://glygen.org/publication/PubMed/17018294" } ] }, { "title": "Human DNA replication-related element binding factor (hDREF) self-association via hATC domain is necessary for its nuclear accumulation and DNA binding.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Yamashita D, Komori H, Higuchi Y, Yamaguchi T, Osumi T, Hirose F", "evidence": [ { "database": "UniProtKB", "id": "O96006", "url": "https://www.uniprot.org/uniprot/O96006" }, { "database": "RefSeq", "id": "NP_001164606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164606" } ], "reference": [ { "type": "PubMed", "id": "17209048", "url": "https://glygen.org/publication/PubMed/17209048" } ] }, { "title": "hDREF regulates cell proliferation and expression of ribosomal protein genes.", "journal": "Molecular and cellular biology", "date": "2007", "authors": "Yamashita D, Sano Y, Adachi Y, Okamoto Y, Osada H, Takahashi T, Yamaguchi T, Osumi T, Hirose F", "evidence": [ { "database": "UniProtKB", "id": "O96006", "url": "https://www.uniprot.org/uniprot/O96006" }, { "database": "RefSeq", "id": "NP_001164606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164606" } ], "reference": [ { "type": "PubMed", "id": "17220279", "url": "https://glygen.org/publication/PubMed/17220279" } ] }, { "title": "SUMO conjugation to the matrix attachment region-binding protein, special AT-rich sequence-binding protein-1 (SATB1), targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Tan JA, Sun Y, Song J, Chen Y, Krontiris TG, Durrin LK", "evidence": [ { "database": "Reactome", "id": "R-HSA-4551638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4551638" } ], "reference": [ { "type": "PubMed", "id": "18408014", "url": "https://glygen.org/publication/PubMed/18408014" } ] }, { "title": "The polycomb repressive complex 2 is a potential target of SUMO modifications.", "journal": "PloS one", "date": "2008", "authors": "Riising EM, Boggio R, Chiocca S, Helin K, Pasini D", "evidence": [ { "database": "Reactome", "id": "R-HSA-4551638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4551638" } ], "reference": [ { "type": "PubMed", "id": "18628979", "url": "https://glygen.org/publication/PubMed/18628979" } ] }, { "title": "Ubc9 sumoylation regulates SUMO target discrimination.", "journal": "Molecular cell", "date": "2008", "authors": "Knipscheer P, Flotho A, Klug H, Olsen JV, van Dijk WJ, Fish A, Johnson ES, Mann M, Sixma TK, Pichler A", "evidence": [ { "database": "Reactome", "id": "R-HSA-4551638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4551638" } ], "reference": [ { "type": "PubMed", "id": "18691969", "url": "https://glygen.org/publication/PubMed/18691969" } ] }, { "title": "Phosphoproteomic analysis of human embryonic stem cells.", "journal": "Cell stem cell", "date": "2009", "authors": "Brill LM, Xiong W, Lee KB, Ficarro SB, Crain A, Xu Y, Terskikh A, Snyder EY, Ding S", "evidence": [ { "database": "iPTMnet", "id": "O96006", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O96006" } ], "reference": [ { "type": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" } ] }, { "title": "A role for non-covalent SUMO interaction motifs in Pc2/CBX4 E3 activity.", "journal": "PloS one", "date": "2010", "authors": "Merrill JC, Melhuish TA, Kagey MH, Yang SH, Sharrocks AD, Wotton D", "evidence": [ { "database": "Reactome", "id": "R-HSA-4551638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4551638" } ], "reference": [ { "type": "PubMed", "id": "20098713", "url": "https://glygen.org/publication/PubMed/20098713" } ] }, { "title": "Phosphorylation-dependent interaction of SATB1 and PIAS1 directs SUMO-regulated caspase cleavage of SATB1.", "journal": "Molecular and cellular biology", "date": "2010", "authors": "Tan JA, Song J, Chen Y, Durrin LK", "evidence": [ { "database": "Reactome", "id": "R-HSA-4551638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4551638" } ], "reference": [ { "type": "PubMed", "id": "20351170", "url": "https://glygen.org/publication/PubMed/20351170" } ] }, { "title": "SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development.", "journal": "Molecular cell", "date": "2010", "authors": "Kang X, Qi Y, Zuo Y, Wang Q, Zou Y, Schwartz RJ, Cheng J, Yeh ET", "evidence": [ { "database": "Reactome", "id": "R-HSA-4551638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4551638" } ], "reference": [ { "type": "PubMed", "id": "20417598", "url": "https://glygen.org/publication/PubMed/20417598" } ] }, { "title": "CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage.", "journal": "Nucleic acids research", "date": "2012", "authors": "Ismail IH, Gagne JP, Caron MC, McDonald D, Xu Z, Masson JY, Poirier GG, Hendzel MJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-4551638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4551638" } ], "reference": [ { "type": "PubMed", "id": "22402492", "url": "https://glygen.org/publication/PubMed/22402492" } ] }, { "title": "Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stress.", "journal": "Journal of molecular cell biology", "date": "2012", "authors": "Brandl A, Wagner T, Uhlig KM, Knauer SK, Stauber RH, Melchior F, Schneider G, Heinzel T, Kramer OH", "evidence": [ { "database": "Reactome", "id": "R-HSA-4551638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4551638" } ], "reference": [ { "type": "PubMed", "id": "22493095", "url": "https://glygen.org/publication/PubMed/22493095" } ] }, { "title": "Targeted identification of SUMOylation sites in human proteins using affinity enrichment and paralog-specific reporter ions.", "journal": "Molecular & cellular proteomics : MCP", "date": "2013", "authors": "Lamoliatte F, Bonneil E, Durette C, Caron-Lizotte O, Wildemann D, Zerweck J, Wenshuk H, Thibault P", "evidence": [ { "database": "Reactome", "id": "R-HSA-4551638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4551638" } ], "reference": [ { "type": "PubMed", "id": "23750026", "url": "https://glygen.org/publication/PubMed/23750026" } ] }, { "title": "A role for paralog-specific sumoylation in histone deacetylase 1 stability.", "journal": "Journal of molecular cell biology", "date": "2013", "authors": "Citro S, Jaffray E, Hay RT, Seiser C, Chiocca S", "evidence": [ { "database": "Reactome", "id": "R-HSA-4551638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4551638" } ], "reference": [ { "type": "PubMed", "id": "24068740", "url": "https://glygen.org/publication/PubMed/24068740" } ] }, { "title": "SUMOylation of the polycomb group protein L3MBTL2 facilitates repression of its target genes.", "journal": "Nucleic acids research", "date": "2014", "authors": "Stielow C, Stielow B, Finkernagel F, Scharfe M, Jarek M, Suske G", "evidence": [ { "database": "Reactome", "id": "R-HSA-4551638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4551638" } ], "reference": [ { "type": "PubMed", "id": "24369422", "url": "https://glygen.org/publication/PubMed/24369422" } ] }, { "title": "Proteome-wide identification of SUMO2 modification sites.", "journal": "Science signaling", "date": "2014", "authors": "Tammsalu T, Matic I, Jaffray EG, Ibrahim AFM, Tatham MH, Hay RT", "evidence": [ { "database": "Reactome", "id": "R-HSA-4551638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4551638" } ], "reference": [ { "type": "PubMed", "id": "24782567", "url": "https://glygen.org/publication/PubMed/24782567" } ] }, { "title": "Adenovirus E1A targets the DREF nuclear factor to regulate virus gene expression, DNA replication, and growth.", "journal": "Journal of virology", "date": "2014", "authors": "Radko S, Koleva M, James KM, Jung R, Mymryk JS, Pelka P", "evidence": [ { "database": "UniProtKB", "id": "O96006", "url": "https://www.uniprot.org/uniprot/O96006" } ], "reference": [ { "type": "PubMed", "id": "25210186", "url": "https://glygen.org/publication/PubMed/25210186" } ] }, { "title": "Large-scale analysis of lysine SUMOylation by SUMO remnant immunoaffinity profiling.", "journal": "Nature communications", "date": "2014", "authors": "Lamoliatte F, Caron D, Durette C, Mahrouche L, Maroui MA, Caron-Lizotte O, Bonneil E, Chelbi-Alix MK, Thibault P", "evidence": [ { "database": "Reactome", "id": "R-HSA-4551638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4551638" } ], "reference": [ { "type": "PubMed", "id": "25391492", "url": "https://glygen.org/publication/PubMed/25391492" } ] }, { "title": "Sumoylation of HDAC2 promotes NF-kappaB-dependent gene expression.", "journal": "Oncotarget", "date": "2015", "authors": "Wagner T, Kiweler N, Wolff K, Knauer SK, Brandl A, Hemmerich P, Dannenberg JH, Heinzel T, Schneider G, Kramer OH", "evidence": [ { "database": "Reactome", "id": "R-HSA-4551638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4551638" } ], "reference": [ { "type": "PubMed", "id": "25704882", "url": "https://glygen.org/publication/PubMed/25704882" } ] }, { "title": "Transcription Factor hDREF Is a Novel SUMO E3 Ligase of Mi2alpha.", "journal": "The Journal of biological chemistry", "date": "2016", "authors": "Yamashita D, Moriuchi T, Osumi T, Hirose F", "evidence": [ { "database": "UniProtKB", "id": "O96006", "url": "https://www.uniprot.org/uniprot/O96006" }, { "database": "Reactome", "id": "R-HSA-4551638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4551638" } ], "reference": [ { "type": "PubMed", "id": "27068747", "url": "https://glygen.org/publication/PubMed/27068747" } ] }, { "title": "Human DREF/ZBED1 is a nuclear protein widely expressed in multiple cell types derived from all three primary germ layers.", "journal": "PloS one", "date": "2018", "authors": "Hansen SV, Traynor S, Ditzel HJ, Gjerstorff MF", "evidence": [ { "database": "RefSeq", "id": "NP_001164606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164606" } ], "reference": [ { "type": "PubMed", "id": "30304065", "url": "https://glygen.org/publication/PubMed/30304065" } ] }, { "title": "ZBED1 Regulates Genes Important for Multiple Biological Processes of the Placenta.", "journal": "Genes", "date": "2022", "authors": "Johansen S, Traynor S, Ebstrup ML, Terp MG, Pedersen CB, Ditzel HJ, Gjerstorff MF", "evidence": [ { "database": "RefSeq", "id": "NP_001164606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164606" } ], "reference": [ { "type": "PubMed", "id": "35052473", "url": "https://glygen.org/publication/PubMed/35052473" } ] }, { "title": "A novel pseudoautosomal human gene encodes a putative protein similar to Ac-like transposases.", "journal": "Hum. Mol. Genet.", "date": "1999", "authors": "Esposito T, Gianfrancesco F, Ciccodicola A, Montanini L, Mumm S, D'Urso M, Forabosco A", "evidence": [ { "database": "UniProtKB", "id": "O96006", "url": "https://www.uniprot.org/uniprot/O96006" } ], "reference": [ { "type": "PubMed", "id": "9887332", "url": "https://glygen.org/publication/PubMed/9887332" } ] } ], "pathway": [ { "id": "hsa:9189", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:9189", "resource": "KEGG Pathway" }, { "id": "R-HSA-4551638", "name": "SUMOylation of chromatin organization proteins", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4551638", "resource": "Reactome", "description": "SUMOylation of chromatin organization proteins" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BCC4-1", "protein_name": "Zinc finger BED domain-containing protein 1", "gene_name": "ZBED1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": 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], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "O96006", "url": "https://www.uniprot.org/uniprot/O96006" } ], "pmid": "" }, { "name": "PML body", "id": "GO:0016605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016605", "evidence": [ { "database": "UniProtKB", "id": "O96006", "url": "https://www.uniprot.org/uniprot/O96006" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "O96006", "url": "https://www.uniprot.org/uniprot/O96006" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "O96006", "url": "https://www.uniprot.org/uniprot/O96006" } ], "pmid": "" }, { "name": "protein sumoylation", "id": "GO:0016925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016925", "evidence": [ { "database": "UniProtKB", "id": "O96006", "url": "https://www.uniprot.org/uniprot/O96006" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "O96006", "url": "https://www.uniprot.org/uniprot/O96006" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "O96006", "url": "https://www.uniprot.org/uniprot/O96006" } ], "pmid": "" }, { "name": "negative regulation by host of viral genome replication", "id": "GO:0044828", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044828", "evidence": [ { "database": "UniProtKB", "id": "O96006", "url": "https://www.uniprot.org/uniprot/O96006" } ], "pmid": "" }, { "name": "protein autosumoylation", "id": "GO:1990466", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990466", "evidence": [ { "database": "UniProtKB", "id": "O96006", "url": "https://www.uniprot.org/uniprot/O96006" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" }, { "start_pos": 431, "end_pos": 433, "annotation": "n_glycosylation_sequon" }, { "start_pos": 59, "end_pos": 61, "annotation": "n_glycosylation_sequon" }, { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Autosumoylated with SUMO1, SUMO2, and SUMO3.", "evidence": [ { "database": "UniProtKB", "id": "O96006", "url": "https://www.uniprot.org/uniprot/O96006" }, { "database": "PubMed", "id": "25210186", "url": "https://glygen.org/publication/PubMed/25210186" }, { "database": "PubMed", "id": "27068747", "url": 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