{
"uniprot_canonical_ac": "O95989-1",
"uniprot_ac": "O95989",
"uniprot_id": "NUDT3_HUMAN",
"mass": {
"chemical_mass": 19471.0,
"monoisotopic_mass": 19471.0
},
"refseq": {
"ac": "NP_006694",
"name": "diphosphoinositol polyphosphate phosphohydrolase 1",
"summary": "NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM, Feb 2011].",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_006694"
},
"gene_names": [
{
"name": "NUDT3",
"resource": "UniProtKB",
"type": "recommended",
"url": "https://www.uniprot.org/uniprot/O95989",
"id": "O95989"
},
{
"name": "DIPP1",
"resource": "UniProtKB",
"type": "synonym",
"url": "https://www.uniprot.org/uniprot/O95989",
"id": "O95989"
},
{
"name": "DIPP; DIPP-1; DIPP1",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_006694",
"id": "NP_006694"
},
{
"name": "DIPP",
"resource": "UniProtKB",
"type": "synonym",
"url": "https://www.uniprot.org/uniprot/O95989",
"id": "O95989"
},
{
"name": "NUDT3",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_006694",
"id": "NP_006694"
}
],
"protein_names": [
{
"name": "Diphosphoinositol polyphosphate phosphohydrolase 1",
"resource": "UniProtKB",
"type": "recommended",
"url": "",
"id": "O95989"
},
{
"name": "3.6.1.10",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O95989"
},
{
"name": "3.6.1.52",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O95989"
},
{
"name": "3.6.1.59",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O95989"
},
{
"name": "3.6.1.61",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O95989"
},
{
"name": "3.6.1.62",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O95989"
},
{
"name": "Ap6A hydrolase",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O95989"
},
{
"name": "DIPP-1",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O95989"
},
{
"name": "Diadenosine hexaphosphate hydrolase",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O95989"
},
{
"name": "Endopolyphosphatase",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O95989"
},
{
"name": "Nucleoside diphosphate-linked moiety X motif 3",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O95989"
},
{
"name": "Nudix motif 3",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O95989"
},
{
"name": "diphosphoinositol polyphosphate phosphohydrolase 1",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_006694",
"id": "NP_006694"
},
{
"name": "m7GpppN-mRNA hydrolase",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O95989"
},
{
"name": "m7GpppX diphosphatase",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O95989"
},
{
"name": "nudix (nucleoside diphosphate linked moiety X)-type motif 3; nudix motif 3; nucleoside diphosphate-linked moiety X motif 3; diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1; ap6A hydrolase; endopolyphosphatase; m7GpppX diphosphatase; m7GpppN-mRNA hydrolase; diadenosine hexaphosphate hydrolase",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_006694",
"id": "NP_006694"
}
],
"function": [
{
"annotation": "Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PubMed:12370170, PubMed:9822604, PubMed:10585413). InsP6 (inositol hexakisphosphate) is not a substrate (PubMed:9822604). Acts as a negative regulator of the ERK1/2 pathway (By similarity). Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) and diadenosine 5',5'''- P1,P5-pentaphosphate (Ap5A) being the preferred substrates (PubMed:12370170, PubMed:10419486). The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A (PubMed:12370170). Also able to hydrolyze 5-phosphoribose 1-diphosphate (PubMed:12370170). Acts as a decapping enzyme that modulates the stability of a subset of mRNAs implicated in cell motility (PubMed:26932476). Hydrolyzes monomethylated capped RNA after both the alpha- and beta-phosphates generating m7GMP + ppRNA and m7GDP + pRNA (PubMed:32727897). Can hydrolyze unmethylated capped RNAs (By similarity). Divalent cations zinc, magnesium and manganese determine its substrate specificity (PubMed:34788624). Exhibits diphosphoinositol polyphosphate phosphohydrolase in the presence of magnesium ions, diadenosine hexaphosphate hydrolase activity in the presence of manganese ions and endopolyphosphatase activity in the presence of zinc ions (PubMed:34788624). Plays an important role in limiting DNA damage and maintaining cell survival upon oxidative stress via its endopolyphosphatase activity (PubMed:34788624).",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989#function"
},
{
"database": "PubMed",
"id": "9822604",
"url": "https://glygen.org/publication/PubMed/9822604"
},
{
"database": "PubMed",
"id": "10585413",
"url": "https://glygen.org/publication/PubMed/10585413"
},
{
"database": "PubMed",
"id": "10419486",
"url": "https://glygen.org/publication/PubMed/10419486"
},
{
"database": "PubMed",
"id": "34788624",
"url": "https://glygen.org/publication/PubMed/34788624"
},
{
"database": "UniProtKB",
"id": "Q9JI46",
"url": "https://www.uniprot.org/uniprot/Q9JI46#function"
},
{
"database": "PubMed",
"id": "26932476",
"url": "https://glygen.org/publication/PubMed/26932476"
},
{
"database": "PubMed",
"id": "12370170",
"url": "https://glygen.org/publication/PubMed/12370170"
}
]
},
{
"annotation": "InsP7 is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_006694",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_006694"
},
{
"database": "PubMed",
"id": "32727897",
"url": "https://glygen.org/publication/PubMed/32727897"
}
]
},
{
"annotation": "NUDT3 and KLF5 were found to associate with lean mass and HLA-DQB1-AS1 for hand grip strength as candidate genes to target for these phenotypes in sarcopenia. The associated regulatory SNPs are rs464553, rs1028883 and rs3129753 respectively. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_006694",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_006694"
},
{
"database": "PubMed",
"id": "32093658",
"url": "https://glygen.org/publication/PubMed/32093658"
}
]
},
{
"annotation": "NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM, Feb 2011].",
"evidence": [
{
"database": "RefSeq",
"id": "NP_006694",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_006694"
}
]
},
{
"annotation": "New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_006694",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_006694"
},
{
"database": "PubMed",
"id": "33475202",
"url": "https://glygen.org/publication/PubMed/33475202"
}
]
},
{
"annotation": "Polyphosphate degradation by Nudt3-Zn(2+) mediates oxidative stress response.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_006694",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_006694"
},
{
"database": "PubMed",
"id": "34788624",
"url": "https://glygen.org/publication/PubMed/34788624"
}
]
}
],
"disease": [],
"snv": [],
"mutagenesis": [
{
"start_pos": 50,
"end_pos": 50,
"sequence_org": "G",
"sequence_mut": "A",
"comment": "Loss of diphosphoinositol polyphosphate phosphohydrolase activity.",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
},
{
"database": "PubMed",
"id": "10585413",
"url": "https://glygen.org/publication/PubMed/10585413"
}
]
},
{
"start_pos": 50,
"end_pos": 50,
"sequence_org": "G",
"sequence_mut": "V",
"comment": "Loss of diphosphoinositol polyphosphate phosphohydrolase activity.",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
},
{
"database": "PubMed",
"id": "10585413",
"url": "https://glygen.org/publication/PubMed/10585413"
}
]
},
{
"start_pos": 51,
"end_pos": 51,
"sequence_org": "G",
"sequence_mut": "A",
"comment": "Loss of diphosphoinositol polyphosphate phosphohydrolase activity.",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
},
{
"database": "PubMed",
"id": "10585413",
"url": "https://glygen.org/publication/PubMed/10585413"
}
]
},
{
"start_pos": 52,
"end_pos": 52,
"sequence_org": "G",
"sequence_mut": "A",
"comment": "Loss of diphosphoinositol polyphosphate phosphohydrolase activity.",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
},
{
"database": "PubMed",
"id": "10585413",
"url": "https://glygen.org/publication/PubMed/10585413"
}
]
},
{
"start_pos": 52,
"end_pos": 52,
"sequence_org": "G",
"sequence_mut": "V",
"comment": "Loss of diphosphoinositol polyphosphate phosphohydrolase activity.",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
},
{
"database": "PubMed",
"id": "10585413",
"url": "https://glygen.org/publication/PubMed/10585413"
}
]
},
{
"start_pos": 66,
"end_pos": 66,
"sequence_org": "E",
"sequence_mut": "Q",
"comment": "Loss of diphosphoinositol polyphosphate phosphohydrolase activity.",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
},
{
"database": "PubMed",
"id": "10585413",
"url": "https://glygen.org/publication/PubMed/10585413"
}
]
},
{
"start_pos": 69,
"end_pos": 70,
"sequence_org": "EE",
"sequence_mut": "QQ",
"comment": "Loss of mRNA-decapping activity.",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
},
{
"database": "PubMed",
"id": "26932476",
"url": "https://glygen.org/publication/PubMed/26932476"
}
]
},
{
"start_pos": 70,
"end_pos": 70,
"sequence_org": "E",
"sequence_mut": "A",
"comment": "Loss of endopolyphosphatase activity.",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
},
{
"database": "PubMed",
"id": "34788624",
"url": "https://glygen.org/publication/PubMed/34788624"
}
]
},
{
"start_pos": 70,
"end_pos": 70,
"sequence_org": "E",
"sequence_mut": "Q",
"comment": "Loss of diphosphoinositol polyphosphate phosphohydrolase activity.",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
},
{
"database": "PubMed",
"id": "9822604",
"url": "https://glygen.org/publication/PubMed/9822604"
}
]
},
{
"start_pos": 72,
"end_pos": 72,
"sequence_org": "G",
"sequence_mut": "A",
"comment": "Loss of diphosphoinositol polyphosphate phosphohydrolase activity.",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
},
{
"database": "PubMed",
"id": "10585413",
"url": "https://glygen.org/publication/PubMed/10585413"
}
]
},
{
"start_pos": 75,
"end_pos": 75,
"sequence_org": "G",
"sequence_mut": "A",
"comment": "Loss of diphosphoinositol polyphosphate phosphohydrolase activity.",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
},
{
"database": "PubMed",
"id": "10585413",
"url": "https://glygen.org/publication/PubMed/10585413"
}
]
},
{
"start_pos": 78,
"end_pos": 78,
"sequence_org": "G",
"sequence_mut": "A",
"comment": "No effect on diphosphoinositol polyphosphate phosphohydrolase activity.",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
},
{
"database": "PubMed",
"id": "10585413",
"url": "https://glygen.org/publication/PubMed/10585413"
}
]
},
{
"start_pos": 78,
"end_pos": 78,
"sequence_org": "G",
"sequence_mut": "V",
"comment": "Loss of diphosphoinositol polyphosphate phosphohydrolase activity.",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
},
{
"database": "PubMed",
"id": "10585413",
"url": "https://glygen.org/publication/PubMed/10585413"
}
]
},
{
"start_pos": 82,
"end_pos": 82,
"sequence_org": "G",
"sequence_mut": "A",
"comment": "Loss of diphosphoinositol polyphosphate phosphohydrolase activity.",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
},
{
"database": "PubMed",
"id": "10585413",
"url": "https://glygen.org/publication/PubMed/10585413"
}
]
},
{
"start_pos": 84,
"end_pos": 84,
"sequence_org": "F",
"sequence_mut": "Y",
"comment": "Induces a strong decrease in Ap6A and [PP]-InsP4 hydrolysis, while it only weakly affects PP-InsP5 hydrolysis.",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
},
{
"database": "PubMed",
"id": "10585413",
"url": "https://glygen.org/publication/PubMed/10585413"
}
]
},
{
"start_pos": 91,
"end_pos": 91,
"sequence_org": "H",
"sequence_mut": "L",
"comment": "Induces a strong decrease in Ap6A and [PP]-InsP4 hydrolysis, while it only weakly affects PP-InsP5 hydrolysis.",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
},
{
"database": "PubMed",
"id": "10585413",
"url": "https://glygen.org/publication/PubMed/10585413"
}
]
}
],
"expression_tissue": [
{
"tissue": {
"name": "Adult mammalian kidney",
"namespace": "UBERON",
"id": "0000082",
"url": "http://purl.obolibrary.org/obo/UBERON_0000082"
},
"score": "89.29",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000272325",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000272325"
}
]
},
{
"tissue": {
"name": "Oral cavity",
"namespace": "UBERON",
"id": "0000167",
"url": "http://purl.obolibrary.org/obo/UBERON_0000167"
},
"score": "90.28",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000272325",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000272325"
}
]
},
{
"tissue": {
"name": "Stomach",
"namespace": "UBERON",
"id": "0000945",
"url": "http://purl.obolibrary.org/obo/UBERON_0000945"
},
"score": "86.33",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000272325",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000272325"
}
]
},
{
"tissue": {
"name": "Uterus",
"namespace": "UBERON",
"id": "0000995",
"url": "http://purl.obolibrary.org/obo/UBERON_0000995"
},
"score": "91.7",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000272325",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000272325"
}
]
},
{
"tissue": {
"name": "Esophagus",
"namespace": "UBERON",
"id": "0001043",
"url": "http://purl.obolibrary.org/obo/UBERON_0001043"
},
"score": "83.91",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000272325",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000272325"
}
]
},
{
"tissue": {
"name": "Rectum",
"namespace": "UBERON",
"id": "0001052",
"url": "http://purl.obolibrary.org/obo/UBERON_0001052"
},
"score": "84.46",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000272325",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000272325"
}
]
},
{
"tissue": {
"name": "Colon",
"namespace": "UBERON",
"id": "0001155",
"url": "http://purl.obolibrary.org/obo/UBERON_0001155"
},
"score": "86.64",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000272325",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000272325"
}
]
},
{
"tissue": {
"name": "Urinary bladder",
"namespace": "UBERON",
"id": "0001255",
"url": "http://purl.obolibrary.org/obo/UBERON_0001255"
},
"score": "87.96",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000272325",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000272325"
}
]
},
{
"tissue": {
"name": "Thyroid gland",
"namespace": "UBERON",
"id": "0002046",
"url": "http://purl.obolibrary.org/obo/UBERON_0002046"
},
"score": "86.16",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000272325",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000272325"
}
]
},
{
"tissue": {
"name": "Lung",
"namespace": "UBERON",
"id": "0002048",
"url": "http://purl.obolibrary.org/obo/UBERON_0002048"
},
"score": "87.22",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000272325",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000272325"
}
]
},
{
"tissue": {
"name": "Liver",
"namespace": "UBERON",
"id": "0002107",
"url": "http://purl.obolibrary.org/obo/UBERON_0002107"
},
"score": "86.54",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000272325",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000272325"
}
]
},
{
"tissue": {
"name": "Prostate gland",
"namespace": "UBERON",
"id": "0002367",
"url": "http://purl.obolibrary.org/obo/UBERON_0002367"
},
"score": "81.21",
"present": "LOW",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000272325",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000272325"
}
]
},
{
"tissue": {
"name": "Thoracic mammary gland",
"namespace": "UBERON",
"id": "0005200",
"url": "http://purl.obolibrary.org/obo/UBERON_0005200"
},
"score": "82.74",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000272325",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000272325"
}
]
}
],
"expression_disease": [
{
"significant": "Yes",
"trend": "down",
"name": "Prostate cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10283",
"evidence": [
{
"database": "BioXpress",
"id": "O95989",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95989"
}
],
"disease": [
{
"disease_id": "DOID:10283",
"recommended_name": {
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer",
"description": "A male reproductive organ cancer that is located_in the prostate."
},
"synonyms": [
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "NGP - new growth of prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "malignant tumor of the prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "tumor of the prostate",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, type 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "HPC9",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "EHBP1 familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "familial prostate cancer caused by mutation in EHBP1",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, type 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "HPC12",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, type 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "HPC5",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, type 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, susceptibility to, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "HPC3",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, type 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, susceptibility to, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "HPC4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, on chromosome 7",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "MSMB familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "familial prostate cancer caused by mutation in MSMB",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, type 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "HPC13",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, type 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "HPC8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "predisposing for prostate cancer",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, type 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "HPC6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "HPC10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate carcinoma",
"description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate carcinoma",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, somatic",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, hereditary",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "HPC7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer aggressiveness",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "RNASEL familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "familial prostate cancer caused by mutation in RNASEL",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, type 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "HPC1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "Prca1",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "HPC11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "HPC14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "HPC15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "HPCX1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer susceptibility, X-linked",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "HPCX2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MIM:611868",
"resource": "MIM",
"url": "https://www.omim.org/entry/611868",
"name": "Prostate cancer, hereditary, 12",
"description": "Prostate cancer, hereditary, 12"
},
{
"id": "MIM:611928",
"resource": "MIM",
"url": "https://www.omim.org/entry/611928",
"name": "Prostate cancer, hereditary, 13",
"description": "Prostate cancer, hereditary, 13"
},
{
"id": "MIM:176807",
"resource": "MIM",
"url": "https://www.omim.org/entry/176807",
"name": "Prostate cancer",
"description": "Prostate cancer"
},
{
"id": "MIM:601518",
"resource": "MIM",
"url": "https://www.omim.org/entry/601518",
"name": "Prostate cancer, hereditary, 1",
"description": "Prostate cancer, hereditary, 1"
},
{
"id": "MIM:611955",
"resource": "MIM",
"url": "https://www.omim.org/entry/611955",
"name": "Prostate cancer, hereditary, 11",
"description": "Prostate cancer, hereditary, 11"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Stomach cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10534",
"evidence": [
{
"database": "BioXpress",
"id": "O95989",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95989"
}
],
"disease": [
{
"disease_id": "DOID:10534",
"recommended_name": {
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "stomach cancer",
"description": "A gastrointestinal system cancer that is located_in the stomach."
},
"synonyms": [
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric cancer",
"description": ""
},
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": "A primary or metastatic malignant neoplasm involving the stomach."
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca lesser curvature - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "cancer of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer risk after h. pylori infection",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumor",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumour",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant stomach neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "stomach cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca body - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "ca greater curvature of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, intestinal",
"description": ""
},
{
"id": "MIM:613659",
"resource": "MIM",
"url": "https://www.omim.org/entry/613659",
"name": "Gastric cancer",
"description": "Gastric cancer"
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Urinary bladder cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11054",
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{
"database": "BioXpress",
"id": "O95989",
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{
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{
"id": "DOID:11054",
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{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
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"name": "tumor of the bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "bladder cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "cancer of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder neoplasm",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumor",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumour",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
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"name": "malignant neoplasm of bladder",
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},
{
"id": "MONDO:0001187",
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"name": "malignant neoplasm of the bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, urinary bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumour",
"description": ""
},
{
"id": "MIM:109800",
"resource": "MIM",
"url": "https://www.omim.org/entry/109800",
"name": "Bladder cancer",
"description": "Bladder cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Head and neck cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11934",
"evidence": [
{
"database": "BioXpress",
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}
],
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{
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{
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},
{
"id": "DOID:11934",
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},
{
"id": "DOID:11934",
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},
{
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}
]
}
]
},
{
"significant": "Yes",
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{
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"id": "O95989",
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],
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{
"disease_id": "DOID:1324",
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"synonyms": [
{
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},
{
"id": "MONDO:0012159",
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},
{
"id": "MONDO:0012159",
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},
{
"id": "MONDO:0012159",
"resource": "MONDO",
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},
{
"id": "MONDO:0012942",
"resource": "MONDO",
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},
{
"id": "MONDO:0012942",
"resource": "MONDO",
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"name": "LNCR3",
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},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "adenocarcinoma of lung, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
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"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "LNCR4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
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},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
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},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
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},
{
"id": "MONDO:0013631",
"resource": "MONDO",
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"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": "A malignant neoplasm involving the lung."
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "cancer of lung",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, somatic",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
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},
{
"id": "MONDO:0008903",
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"name": "malignant lung neoplasm",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
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"name": "malignant lung tumor",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumour",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of lung",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
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"name": "malignant tumor of lung",
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},
{
"id": "MONDO:0008903",
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"name": "malignant tumor of the lung",
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},
{
"id": "MONDO:0008903",
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"name": "malignant tumour of lung",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
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"name": "nonsmall cell lung cancer, somatic",
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},
{
"id": "MONDO:0008903",
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"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
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},
{
"id": "MONDO:0008903",
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"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
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"name": "lung neoplasm",
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},
{
"id": "MIM:211980",
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"name": "Lung cancer",
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}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Breast cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1612",
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},
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},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant neoplasm of breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant tumor of the breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary cancer",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "primary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, lobular, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of the breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial Male",
"description": ""
},
{
"id": "MIM:114480",
"resource": "MIM",
"url": "https://www.omim.org/entry/114480",
"name": "Breast cancer",
"description": "Breast cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Thyroid cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1781",
"evidence": [
{
"database": "BioXpress",
"id": "O95989",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95989"
}
],
"disease": [
{
"disease_id": "DOID:1781",
"recommended_name": {
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid cancer",
"description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
},
"synonyms": [
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid gland cancer",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "Thyroid gland neoplasm",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant tumour of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Kidney cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:263",
"evidence": [
{
"database": "BioXpress",
"id": "O95989",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95989"
}
],
"disease": [
{
"disease_id": "DOID:263",
"recommended_name": {
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "kidney cancer",
"description": "A urinary system cancer that is located_in the kidney."
},
"synonyms": [
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant neoplasm of kidney except pelvis",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant tumour of kidney",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "renal cancer",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Liver cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:3571",
"evidence": [
{
"database": "BioXpress",
"id": "O95989",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95989"
}
],
"disease": [
{
"disease_id": "DOID:3571",
"recommended_name": {
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "liver cancer",
"description": "A hepatobiliary system cancer that is located_in the liver."
},
"synonyms": [
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Ca liver - primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Resectable malignant neoplasm of Liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant hepato-biliary neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant tumor of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "non-resectable primary hepatic malignant neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary liver cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "resectable malignant neoplasm of the liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, not specified as primary or secondary",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Uterine cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:363",
"evidence": [
{
"database": "BioXpress",
"id": "O95989",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95989"
}
],
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Esophageal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:5041",
"evidence": [
{
"database": "BioXpress",
"id": "O95989",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95989"
}
],
"disease": [
{
"disease_id": "DOID:5041",
"recommended_name": {
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophageal cancer",
"description": "A gastrointestinal system cancer that is located_in the esophagus."
},
"synonyms": [
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophagus cancer",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Distal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Proximal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of the middle Third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": "A primary or metastatic malignant neoplasm involving the esophagus."
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "oesophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
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"sequence": "MMKLKSNQTRTYDGDGYKKRAACLCFRSESEEEVLLVSSSRHPDRWIVPGGGMEPEEEPSVAAVREVCEEAGVKGTLGRLVGIFENQERKHRTYVYVLIVTEVLEDWEDSVNIGRKREWFKIEDAIKVLQCHKPVQASYFETLRQGYPANNGTPVVPTTYSSSVSGIR",
"length": 168
},
"evidence": [
{
"id": "45925174",
"url": "http://www.informatics.jax.org/homology/45925174",
"database": "MGI"
},
{
"id": "O95989",
"url": "https://omabrowser.org/oma/group/O95989/",
"database": "OMA"
}
],
"common_name": "Mouse"
}
],
"go_annotation": {
"categories": [
{
"name": "Molecular Function",
"total": 13,
"go_terms": [
{
"name": "endopolyphosphatase activity",
"id": "GO:0000298",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000298",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
}
],
"pmid": ""
},
{
"name": "diphosphoinositol-polyphosphate diphosphatase activity",
"id": "GO:0008486",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008486",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
}
],
"pmid": ""
},
{
"name": "bis(5'-adenosyl)-hexaphosphatase activity",
"id": "GO:0034431",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034431",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
}
],
"pmid": ""
},
{
"name": "bis(5'-adenosyl)-pentaphosphatase activity",
"id": "GO:0034432",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034432",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
}
],
"pmid": ""
},
{
"name": "inositol diphosphate tetrakisphosphate diphosphatase activity",
"id": "GO:0052840",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052840",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
}
],
"pmid": ""
},
{
"name": "inositol diphosphate pentakisphosphate diphosphatase activity",
"id": "GO:0052842",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052842",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
}
],
"pmid": ""
},
{
"name": "inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity",
"id": "GO:0052845",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052845",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
}
],
"pmid": ""
},
{
"name": "inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity",
"id": "GO:0052848",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052848",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
}
],
"pmid": ""
},
{
"name": "magnesium ion binding",
"id": "GO:0000287",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
}
],
"pmid": ""
},
{
"name": "zinc ion binding",
"id": "GO:0008270",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
}
],
"pmid": ""
},
{
"name": "manganese ion binding",
"id": "GO:0030145",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030145",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
}
],
"pmid": ""
},
{
"name": "5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity",
"id": "GO:0140932",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140932",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
}
],
"pmid": ""
},
{
"name": "5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity",
"id": "GO:0140933",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140933",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
}
],
"pmid": ""
}
]
},
{
"name": "Biological Process",
"total": 8,
"go_terms": [
{
"name": "diadenosine polyphosphate catabolic process",
"id": "GO:0015961",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015961",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
}
],
"pmid": ""
},
{
"name": "diphosphoinositol polyphosphate metabolic process",
"id": "GO:0071543",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071543",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
}
],
"pmid": ""
},
{
"name": "diphosphoinositol polyphosphate catabolic process",
"id": "GO:0071544",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071544",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
}
],
"pmid": ""
},
{
"name": "diadenosine pentaphosphate catabolic process",
"id": "GO:1901907",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901907",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
}
],
"pmid": ""
},
{
"name": "diadenosine hexaphosphate catabolic process",
"id": "GO:1901909",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901909",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
}
],
"pmid": ""
},
{
"name": "adenosine 5'-(hexahydrogen pentaphosphate) catabolic process",
"id": "GO:1901911",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901911",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
}
],
"pmid": ""
},
{
"name": "cell-cell signaling",
"id": "GO:0007267",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007267",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
}
],
"pmid": ""
},
{
"name": "RNA decapping",
"id": "GO:0110154",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0110154",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
}
],
"pmid": ""
}
]
},
{
"name": "Cellular Component",
"total": 3,
"go_terms": [
{
"name": "nucleus",
"id": "GO:0005634",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
}
],
"pmid": ""
},
{
"name": "cytoplasm",
"id": "GO:0005737",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
}
],
"pmid": ""
},
{
"name": "cytosol",
"id": "GO:0005829",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
"evidence": [
{
"database": "UniProtKB",
"id": "O95989",
"url": "https://www.uniprot.org/uniprot/O95989"
}
],
"pmid": ""
}
]
}
]
},
"pro_annotation": [],
"site_annotation": [
{
"start_pos": 151,
"end_pos": 153,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 7,
"end_pos": 9,
"annotation": "n_glycosylation_sequon"
}
],
"ptm_annotation": [],
"interactions": [],
"reactions": [
{
"id": "22384",
"name": "",
"equation": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + H(+) + phosphate",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q566C7-1",
"Q99MY2-1",
"Q9NZJ9-1",
"O95989-1",
"Q8R2U6-1",
"Q9JI46-1",
"P53965-1"
],
"evidence": [
{
"id": "22384",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/22384"
}
]
},
{
"id": "22452",
"name": "",
"equation": "[phosphate](n+1) + n H2O = n H(+) + (n+1) phosphate",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q566C7-1",
"O95989-1",
"Q9JI46-1",
"P40152-1",
"Q04119-1",
"Q99321-1"
],
"evidence": [
{
"id": "22452",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/22452"
}
]
},
{
"id": "30527",
"name": "",
"equation": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate = ADP + ATP + 2 H(+)",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q566C7-1",
"O95989-1",
"Q9JI46-1"
],
"evidence": [
{
"id": "30527",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/30527"
}
]
},
{
"id": "32039",
"name": "",
"equation": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = AMP + ATP + 2 H(+)",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q924C3-1",
"Q566C7-1",
"P22413-1",
"O95989-1",
"P06802-1",
"Q9JI46-1"
],
"evidence": [
{
"id": "32039",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/32039"
}
]
},
{
"id": "32043",
"name": "",
"equation": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = 2 ATP + 2 H(+)",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q566C7-1",
"O95989-1",
"Q9JI46-1"
],
"evidence": [
{
"id": "32043",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/32043"
}
]
},
{
"id": "56312",
"name": "",
"equation": "3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q566C7-1",
"Q99MY2-1",
"Q9NZJ9-1",
"O95989-1",
"Q8R2U6-1",
"Q9JI46-1",
"P53965-1"
],
"evidence": [
{
"id": "56312",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/56312"
}
]
},
{
"id": "65388",
"name": "",
"equation": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q8K4F7-1",
"P61131-1",
"Q566C7-1",
"Q96C86-1",
"O95989-1",
"Q9DAR7-1",
"Q9JI46-1",
"Q06151-1",
"Q9VNH5-1"
],
"evidence": [
{
"id": "65388",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/65388"
}
]
},
{
"id": "67484",
"name": "",
"equation": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"D4AE80-1",
"D3ZZJ7-1",
"Q566C7-1",
"G3V7P6-1",
"Q9NPI6-1",
"Q8IU60-1",
"Q8IZD4-1",
"Q96DE0-1",
"O95989-1",
"Q91YD3-1",
"Q3U564-1",
"Q6P3D0-1",
"Q9CYC6-1",
"E9Q9G1-1",
"Q9JI46-1",
"P53550-1"
],
"evidence": [
{
"id": "67484",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/67484"
}
]
},
{
"id": "R-HSA-1855165",
"name": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol",
"equation": "",
"summary": "Diphosphoinositol polyphosphate phosphohydrolases (DIPP), also known as nucleoside diphosphate-linked moiety X motif (NUDT) proteins, dephosphorylate inositol bisdiphospho-tetrakisphosphate ((PP)2-IP4) to inositol 5-diphospho-1,2,3,4,6-pentakisphosphate (5-PP-IP5). The NUDT proteins involved are: nucleoside diphosphate-linked moiety X motif 3 (NUDT3), 4 (NUDT4), 10 (NUDT10), and 11 (NUDT11). The reactants consumed are: inositol 1,5-bisdiphospho-2,3,4,6-tetrakisphosphate (1,5-(PP)2-IP4) and inositol 3,5-bisdiphospho-1,2,4,6-tetrakisphosphate (3,5-(PP)2-IP4).
The following lists the above proteins with their corresponding literature references: NUDT3 (Safrany et al. 1999, Safrany et al. 1998, Yang et al. 1999, Caffrey et al. 2000), NUDT4 (Caffrey et al. 2000), NUDT10 (Leslie et al. 2002, Hidaka et al. 2002) and NUDT11 (Leslie et al. 2002, Hidaka et al. 2002).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q9NZJ9-1",
"O95989-1",
"Q96G61-1",
"Q8NFP7-1"
],
"evidence": [
{
"id": "R-HSA-1855165",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855165"
}
]
},
{
"id": "R-HSA-1855198",
"name": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol",
"equation": "",
"summary": "Diphosphoinositol polyphosphate phosphohydrolases (DIPP), also known as nucleoside diphosphate-linked moiety X motif (NUDT) proteins, dephosphorylate inositol 5-diphospho-1,2,3,4,6-pentakisphosphate (5-PP-IP5) to inositol 1,2,3,4,5,6-hexakisphosphate (IP6). The NUDT proteins involved are: nucleoside diphosphate-linked moiety X motif 3 (NUDT3), 4 (NUDT4), 10 (NUDT10), and 11 (NUDT11).
The following lists the above proteins with their corresponding literature references: NUDT3 (Safrany et al. 1999, Safrany et al. 1998, Yang et al. 1999, Caffrey et al. 2000), NUDT4 (Caffrey et al. 2000), NUDT10 (Leslie et al. 2002, Hidaka et al. 2002) and NUDT11 (Leslie et al. 2002, Hidaka et al. 2002).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q9NZJ9-1",
"O95989-1",
"Q96G61-1",
"Q8NFP7-1"
],
"evidence": [
{
"id": "R-HSA-1855198",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855198"
}
]
},
{
"id": "R-HSA-2023971",
"name": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol",
"equation": "",
"summary": "Diphosphoinositol polyphosphate phosphohydrolases, also known as nucleoside diphosphate-linked moiety X motif (NUDT) proteins, dephosphorylate inositol diphospho-pentakisphosphate (PP-IP5) to inositol 1,2,3,4,5,6-hexakisphosphate (IP6). The NUDT proteins involved are: nucleoside diphosphate-linked moiety X motif 3 (NUDT3), 4 (NUDT4), 10 (NUDT10), and 11 (NUDT11). The reactants consumed are: inositol 1-diphospho-2,3,4,5,6-pentakisphosphate (1-PP-IP5) and 3-diphospho-1,2,4,5,6-pentakisphosphate (3-PP-IP5).
The following lists the above proteins with their corresponding literature references: NUDT3 (Safrany et al. 1999, Safrany et al. 1998, Yang et al. 1999, Caffrey et al. 2000), NUDT4 (Caffrey et al. 2000), NUDT10 (Leslie et al. 2002, Hidaka et al. 2002) and NUDT11 (Leslie et al. 2002, Hidaka et al. 2002).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q9NZJ9-1",
"O95989-1",
"Q96G61-1",
"Q8NFP7-1"
],
"evidence": [
{
"id": "R-HSA-2023971",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2023971"
}
]
},
{
"id": "R-HSA-2023973",
"name": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol",
"equation": "",
"summary": "Diphosphoinositol polyphosphate phosphohydrolases (DIPP), also known as nucleoside diphosphate-linked moiety X motif (NUDT) proteins, dephosphorylate inositol bisdiphospho-tetrakisphosphate ((PP)2-IP4) to inositol diphospho-pentakisphosphate (PP-IP5). The NUDT proteins involved are: nucleoside diphosphate-linked moiety X motif 3 (NUDT3), 4 (NUDT4), 10 (NUDT10), and 11 (NUDT11). The reactants consumed are: inositol 1,5-bisdiphospho-2,3,4,6-tetrakisphosphate (1,5-(PP)2-IP4) and inositol 3,5-bisdiphospho-1,2,4,6-tetrakisphosphate (3,5-(PP)2-IP4). The products made are: inositol 1-diphospho-2,3,4,5,6-pentakisphosphate (1-PP-IP5) and 3-diphospho-1,2,4,5,6-pentakisphosphate (3-PP-IP5).
The following lists the above proteins with their corresponding literature references: NUDT3 (Safrany et al. 1999, Safrany et al. 1998, Yang et al. 1999, Caffrey et al. 2000), NUDT4 (Caffrey et al. 2000), NUDT10 (Leslie et al. 2002, Hidaka et al. 2002) and NUDT11 (Leslie et al. 2002, Hidaka et al. 2002).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q9NZJ9-1",
"O95989-1",
"Q96G61-1",
"Q8NFP7-1"
],
"evidence": [
{
"id": "R-HSA-2023973",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2023973"
}
]
}
],
"reaction_participants": [],
"reaction_enzymes": [
{
"uniprot_ac": "D3ZZJ7",
"gene_name": "Dcp1b",
"activity": [
{
"ec_number": "3.6.1.62",
"activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP.",
"evidence": [
{
"id": "D3ZZJ7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZZJ7"
}
]
},
{
"ec_number": "3.6.1.62",
"activity": "",
"evidence": [
{
"id": "D3ZZJ7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZZJ7"
}
]
}
]
},
{
"uniprot_ac": "D4AE80",
"gene_name": "Dcp1a",
"activity": [
{
"ec_number": "3.6.1.62",
"activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP.",
"evidence": [
{
"id": "D4AE80",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4AE80"
}
]
},
{
"ec_number": "3.6.1.62",
"activity": "",
"evidence": [
{
"id": "D4AE80",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4AE80"
}
]
}
]
},
{
"uniprot_ac": "E9Q9G1",
"gene_name": "Nudt16l2",
"activity": [
{
"ec_number": "3.6.1.62",
"activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP.",
"evidence": [
{
"id": "E9Q9G1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9Q9G1"
}
]
},
{
"ec_number": "3.6.1.64",
"activity": "H2O + IDP = H(+) + IMP + phosphate.",
"evidence": [
{
"id": "E9Q9G1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9Q9G1"
}
]
},
{
"ec_number": "3.6.1.62",
"activity": "",
"evidence": [
{
"id": "E9Q9G1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9Q9G1"
}
]
},
{
"ec_number": "3.6.1.64",
"activity": "",
"evidence": [
{
"id": "E9Q9G1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9Q9G1"
}
]
}
]
},
{
"uniprot_ac": "G3V7P6",
"gene_name": "Nudt16",
"activity": [
{
"ec_number": "3.6.1.62",
"activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP.",
"evidence": [
{
"id": "G3V7P6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/G3V7P6"
}
]
},
{
"ec_number": "3.6.1.64",
"activity": "H2O + IDP = H(+) + IMP + phosphate.",
"evidence": [
{
"id": "G3V7P6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/G3V7P6"
}
]
},
{
"ec_number": "3.6.1.64",
"activity": "",
"evidence": [
{
"id": "G3V7P6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/G3V7P6"
}
]
},
{
"ec_number": "3.6.1.62",
"activity": "",
"evidence": [
{
"id": "G3V7P6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/G3V7P6"
}
]
}
]
},
{
"uniprot_ac": "O95989",
"gene_name": "NUDT3",
"activity": [
{
"ec_number": "3.6.1.59",
"activity": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O = (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+).",
"evidence": [
{
"id": "O95989",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95989"
}
]
},
{
"ec_number": "3.6.1.52",
"activity": "5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate.",
"evidence": [
{
"id": "O95989",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95989"
}
]
},
{
"ec_number": "3.6.1.62",
"activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP.",
"evidence": [
{
"id": "O95989",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95989"
}
]
},
{
"ec_number": "3.6.1.10",
"activity": "[phosphate](n+1) + n H2O = n H(+) + (n+1) phosphate.",
"evidence": [
{
"id": "O95989",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95989"
}
]
},
{
"ec_number": "3.6.1.61",
"activity": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = 2 ATP + 2 H(+).",
"evidence": [
{
"id": "O95989",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95989"
}
]
},
{
"ec_number": "3.6.1.52",
"activity": "",
"evidence": [
{
"id": "O95989",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95989"
}
]
}
]
},
{
"uniprot_ac": "P06802",
"gene_name": "Enpp1",
"activity": [
{
"ec_number": "3.1.4.1",
"activity": "Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.",
"evidence": [
{
"id": "P06802",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06802"
}
]
},
{
"ec_number": "3.6.1.9",
"activity": "CTP + H2O = CMP + diphosphate + H(+).",
"evidence": [
{
"id": "P06802",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06802"
}
]
}
]
},
{
"uniprot_ac": "P22413",
"gene_name": "ENPP1",
"activity": [
{
"ec_number": "3.1.4.1",
"activity": "Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.",
"evidence": [
{
"id": "P22413",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22413"
}
]
},
{
"ec_number": "3.6.1.9",
"activity": "CTP + H2O = CMP + diphosphate + H(+).",
"evidence": [
{
"id": "P22413",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22413"
}
]
}
]
},
{
"uniprot_ac": "P40152",
"gene_name": "PPN2",
"activity": [
{
"ec_number": "3.6.1.10",
"activity": "[phosphate](n+1) + n H2O = n H(+) + (n+1) phosphate.",
"evidence": [
{
"id": "P40152",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40152"
}
]
},
{
"ec_number": "3.6.1.10",
"activity": "",
"evidence": [
{
"id": "P40152",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40152"
}
]
}
]
},
{
"uniprot_ac": "P53550",
"gene_name": "DCP2",
"activity": [
{
"ec_number": "3.6.1.62",
"activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP.",
"evidence": [
{
"id": "P53550",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53550"
}
]
},
{
"ec_number": "3.6.1.62",
"activity": "",
"evidence": [
{
"id": "P53550",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53550"
}
]
}
]
},
{
"uniprot_ac": "P53965",
"gene_name": "SIW14",
"activity": [
{
"ec_number": "3.6.1.52",
"activity": "5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate.",
"evidence": [
{
"id": "P53965",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53965"
}
]
},
{
"ec_number": "3.6.1.52",
"activity": "",
"evidence": [
{
"id": "P53965",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53965"
}
]
}
]
},
{
"uniprot_ac": "P61131",
"gene_name": "St3gal4",
"activity": [
{
"ec_number": "3.6.1.59",
"activity": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O = (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+).",
"evidence": [
{
"id": "P61131",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61131"
}
]
},
{
"ec_number": "3.6.1.59",
"activity": "",
"evidence": [
{
"id": "P61131",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61131"
}
]
},
{
"ec_number": "2.4.3.2",
"activity": "a ganglioside GM1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a (d18:1(4E)) + CMP + H(+).",
"evidence": [
{
"id": "P61131",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61131"
}
]
},
{
"ec_number": "2.4.3.4",
"activity": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+).",
"evidence": [
{
"id": "P61131",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61131"
}
]
},
{
"ec_number": "2.4.3.6",
"activity": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+).",
"evidence": [
{
"id": "P61131",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61131"
}
]
},
{
"ec_number": "2.4.3.2",
"activity": "",
"evidence": [
{
"id": "P61131",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61131"
}
]
},
{
"ec_number": "2.4.3.4",
"activity": "",
"evidence": [
{
"id": "P61131",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61131"
}
]
}
]
},
{
"uniprot_ac": "Q04119",
"gene_name": "PPN1",
"activity": [
{
"ec_number": "3.6.1.-",
"activity": "",
"evidence": [
{
"id": "Q04119",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04119"
}
]
},
{
"ec_number": "3.6.1.10",
"activity": "[phosphate](n+1) + n H2O = n H(+) + (n+1) phosphate.",
"evidence": [
{
"id": "Q04119",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04119"
}
]
},
{
"ec_number": "3.6.1.11",
"activity": "[phosphate](n) + H2O = [phosphate](n-1) + H(+) + phosphate.",
"evidence": [
{
"id": "Q04119",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04119"
}
]
},
{
"ec_number": "3.6.1.10",
"activity": "",
"evidence": [
{
"id": "Q04119",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04119"
}
]
}
]
},
{
"uniprot_ac": "Q06151",
"gene_name": "DCS1",
"activity": [
{
"ec_number": "3.6.1.59",
"activity": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O = (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+).",
"evidence": [
{
"id": "Q06151",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q06151"
}
]
},
{
"ec_number": "3.6.1.59",
"activity": "",
"evidence": [
{
"id": "Q06151",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q06151"
}
]
}
]
},
{
"uniprot_ac": "Q3U564",
"gene_name": "Dcp1b",
"activity": [
{
"ec_number": "3.6.1.62",
"activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP.",
"evidence": [
{
"id": "Q3U564",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3U564"
}
]
},
{
"ec_number": "3.6.1.62",
"activity": "",
"evidence": [
{
"id": "Q3U564",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3U564"
}
]
}
]
},
{
"uniprot_ac": "Q566C7",
"gene_name": "Nudt3",
"activity": [
{
"ec_number": "3.6.1.52",
"activity": "5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate.",
"evidence": [
{
"id": "Q566C7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q566C7"
}
]
},
{
"ec_number": "3.6.1.52",
"activity": "",
"evidence": [
{
"id": "Q566C7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q566C7"
}
]
},
{
"ec_number": "3.6.1.59",
"activity": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O = (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+).",
"evidence": [
{
"id": "Q566C7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q566C7"
}
]
},
{
"ec_number": "3.6.1.62",
"activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP.",
"evidence": [
{
"id": "Q566C7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q566C7"
}
]
},
{
"ec_number": "3.6.1.10",
"activity": "[phosphate](n+1) + n H2O = n H(+) + (n+1) phosphate.",
"evidence": [
{
"id": "Q566C7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q566C7"
}
]
},
{
"ec_number": "3.6.1.61",
"activity": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = 2 ATP + 2 H(+).",
"evidence": [
{
"id": "Q566C7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q566C7"
}
]
}
]
},
{
"uniprot_ac": "Q6P3D0",
"gene_name": "Nudt16",
"activity": [
{
"ec_number": "3.6.1.62",
"activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP.",
"evidence": [
{
"id": "Q6P3D0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P3D0"
}
]
},
{
"ec_number": "3.6.1.64",
"activity": "H2O + IDP = H(+) + IMP + phosphate.",
"evidence": [
{
"id": "Q6P3D0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P3D0"
}
]
},
{
"ec_number": "3.6.1.62",
"activity": "",
"evidence": [
{
"id": "Q6P3D0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P3D0"
}
]
},
{
"ec_number": "3.6.1.64",
"activity": "",
"evidence": [
{
"id": "Q6P3D0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P3D0"
}
]
}
]
},
{
"uniprot_ac": "Q8IU60",
"gene_name": "DCP2",
"activity": [
{
"ec_number": "3.6.1.62",
"activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP.",
"evidence": [
{
"id": "Q8IU60",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IU60"
}
]
},
{
"ec_number": "3.6.1.62",
"activity": "",
"evidence": [
{
"id": "Q8IU60",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IU60"
}
]
}
]
},
{
"uniprot_ac": "Q8IZD4",
"gene_name": "DCP1B",
"activity": [
{
"ec_number": "3.6.1.62",
"activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP.",
"evidence": [
{
"id": "Q8IZD4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IZD4"
}
]
},
{
"ec_number": "3.6.1.62",
"activity": "",
"evidence": [
{
"id": "Q8IZD4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IZD4"
}
]
}
]
},
{
"uniprot_ac": "Q8K4F7",
"gene_name": "Dcps",
"activity": [
{
"ec_number": "3.6.1.59",
"activity": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(ribonucleoside) in mRNA + H2O = (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+).",
"evidence": [
{
"id": "Q8K4F7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K4F7"
}
]
},
{
"ec_number": "3.6.1.59",
"activity": "",
"evidence": [
{
"id": "Q8K4F7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K4F7"
}
]
}
]
},
{
"uniprot_ac": "Q8NFP7",
"gene_name": "NUDT10",
"activity": [
{
"ec_number": "3.6.1.52",
"activity": "5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate.",
"evidence": [
{
"id": "Q8NFP7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NFP7"
}
]
},
{
"ec_number": "3.6.1.60",
"activity": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate = adenosine 5'-tetraphosphate + AMP + 2 H(+).",
"evidence": [
{
"id": "Q8NFP7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NFP7"
}
]
},
{
"ec_number": "3.6.1.52",
"activity": "",
"evidence": [
{
"id": "Q8NFP7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NFP7"
}
]
}
]
},
{
"uniprot_ac": "Q8R2U6",
"gene_name": "Nudt4",
"activity": [
{
"ec_number": "3.6.1.-",
"activity": "",
"evidence": [
{
"id": "Q8R2U6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8R2U6"
}
]
},
{
"ec_number": "3.6.1.52",
"activity": "5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate.",
"evidence": [
{
"id": "Q8R2U6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8R2U6"
}
]
},
{
"ec_number": "3.6.1.52",
"activity": "",
"evidence": [
{
"id": "Q8R2U6",
"database": "UniProtKB",
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