{ "uniprot_canonical_ac": "O95980-1", "uniprot_ac": "O95980", "uniprot_id": "RECK_HUMAN", "mass": { "chemical_mass": 106457.0, "monoisotopic_mass": 106457.0 }, "refseq": { "ac": "NP_066934", "name": "reversion-inducing cysteine-rich protein with Kazal motifs isoform 1 precursor", "summary": "The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066934" }, "gene_names": [ { "name": "RECK", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O95980", "id": "O95980" }, { "name": "RECK", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066934", "id": "NP_066934" }, { "name": "ST15", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066934", "id": "NP_066934" }, { "name": "ST15", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95980", "id": "O95980" } ], "protein_names": [ { "name": "Reversion-inducing cysteine-rich protein with Kazal motifs", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O95980" }, { "name": "Suppressor of tumorigenicity 15 protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95980" }, { "name": "hRECK", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95980" }, { "name": "reversion-inducing cysteine-rich protein with Kazal motifs isoform 1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066934", "id": "NP_066934" }, { "name": "suppression of tumorigenicity 5 (reversion-inducing-cysteine-rich protein with kazal motifs); membrane-anchored glycoprotein (metastasis and invasion); suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs); reversion-inducing cysteine-rich protein with Kazal motifs; suppressor of tumorigenicity 15 protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066934", "id": "NP_066934" } ], "function": [ { "annotation": "Four SNPs were identified in the coding region of the gene (exons 1, 9, 13 and 15), and the remaining nine in introns 5, 8, 10, 12, 15 and 17.", "evidence": [ { "database": "RefSeq", "id": "NP_066934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066934" }, { "database": "PubMed", "id": "12438739", "url": "https://glygen.org/publication/PubMed/12438739" } ] }, { "annotation": "Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (PubMed:30026314). ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity (PubMed:9789069, PubMed:18194466). Also inhibits metalloproteinase activity of MMP2 and MMP14 (MT1-MMP) (PubMed:9789069).", "evidence": [ { "database": "UniProtKB", "id": "O95980", "url": "https://www.uniprot.org/uniprot/O95980#function" }, { "database": "PubMed", "id": "9789069", "url": "https://glygen.org/publication/PubMed/9789069" }, { "database": "PubMed", "id": "30026314", "url": "https://glygen.org/publication/PubMed/30026314" }, { "database": "PubMed", "id": "18194466", "url": "https://glygen.org/publication/PubMed/18194466" }, { "database": "UniProtKB", "id": "Q9Z0J1", "url": "https://www.uniprot.org/uniprot/Q9Z0J1#function" }, { "database": "PubMed", "id": "28289266", "url": "https://glygen.org/publication/PubMed/28289266" } ] }, { "annotation": "High RECK protein is associated with invasiveness of pancreatic cancer by MMP-2 activation", "evidence": [ { "database": "RefSeq", "id": "NP_066934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066934" }, { "database": "PubMed", "id": "12738734", "url": "https://glygen.org/publication/PubMed/12738734" } ] }, { "annotation": "Identification of RECK as a protective prognostic indicator and a tumor suppressor through regulation of the ERK/MAPK signaling pathway in gastric cancer. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_066934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066934" }, { "database": "PubMed", "id": "37904179", "url": "https://glygen.org/publication/PubMed/37904179" } ] }, { "annotation": "Mycoplasma pneumoniae downregulates RECK to promote matrix metalloproteinase-9 secretion by bronchial epithelial cells.", "evidence": [ { "database": "RefSeq", "id": "NP_066934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066934" }, { "database": "PubMed", "id": "35892136", "url": "https://glygen.org/publication/PubMed/35892136" } ] }, { "annotation": "RECK Variants are Associated with Clinicopathological Features and Decreased Susceptibility in Mexican Patients with Colorectal Cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_066934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066934" }, { "database": "PubMed", "id": "35444107", "url": "https://glygen.org/publication/PubMed/35444107" } ] }, { "annotation": "RECK gene polymorphisms in hepatitis B-related hepatocellular carcinoma: A case-control study.", "evidence": [ { "database": "RefSeq", "id": "NP_066934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066934" }, { "database": "PubMed", "id": "35941073", "url": "https://glygen.org/publication/PubMed/35941073" } ] }, { "annotation": "The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].", "evidence": [ { "database": "RefSeq", "id": "NP_066934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066934" } ] }, { "annotation": "[miR-181c promotes the migration and angiogenesis of human A549 cells via targeting inhibition of reversion-inducing cysteine-rich protein with Kazal motifs (RECK)].", "evidence": [ { "database": "RefSeq", "id": "NP_066934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066934" }, { "database": "PubMed", "id": "36585230", "url": "https://glygen.org/publication/PubMed/36585230" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs1564119335", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1564119335" }, { "id": "rs1564119335", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1564119335" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 200, "end_pos": 200, "sequence_org": "N", "sequence_mut": "D", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NYT->DYT).", "chr_id": "9", "chr_pos": "36083523", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N200", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs774567853", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs774567853" }, { "id": "rs774567853", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs774567853" }, { "id": "rs774567853", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs774567853#frequency_tab" }, { "id": "rs774567853", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs774567853" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 200, "end_pos": 200, "sequence_org": "N", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NYT->IYT).", "chr_id": "9", "chr_pos": "36083524", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N200", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs774567853", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs774567853" }, { "id": "rs774567853", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs774567853" }, { "id": "rs774567853", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs774567853#frequency_tab" }, { "id": "rs774567853", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs774567853" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 200, "end_pos": 200, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NYT->SYT).", "chr_id": "9", "chr_pos": "36083524", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N200", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs774567853", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs774567853" }, { "id": "rs774567853", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs774567853" }, { "id": "rs774567853", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs774567853#frequency_tab" }, { "id": "rs774567853", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs774567853" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 200, "end_pos": 200, "sequence_org": "N", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NYT->TYT).", "chr_id": "9", "chr_pos": "36083524", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N200", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O95980", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O95980" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 236, "end_pos": 236, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "K", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (KKT->NKT).", "chr_id": "9", "chr_pos": "36087764", "ref_nt": "G", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "K236", "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of 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"Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematologic malignancy", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematologic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematological tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "blood cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic and lymphoid system tumor", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "malignant hematopoietic neoplasm", "description": "" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": 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"resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", 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"sp|O95980-1|RECK_HUMAN Isoform 1 of Reversion-inducing cysteine-rich protein with Kazal motifs OS=Homo sapiens OX=9606 GN=RECK PE=1 SV=1 CANONICAL=O95980-1" }, "isoforms": [ { "isoform_ac": "O95980-1", "url": "", "sequence": { "sequence": 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"sp|O95980-1|RECK_HUMAN Isoform 1 of Reversion-inducing cysteine-rich protein with Kazal motifs OS=Homo sapiens OX=9606 GN=RECK PE=1 SV=1 CANONICAL=O95980-1" }, "locus": { "chromosome": "9", "start_pos": 36123042, "end_pos": 36036999, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000377966.4", "url": "https://www.ensembl.org/id/ENST00000377966.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000367202.3", "url": "https://www.ensembl.org/id/ENSP00000367202.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 200, "start_aa": "Asn", "end_pos": 200, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn200", "evidence": [ { "id": "O95980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95980#ptm_processing" }, { "id": "16103099", "database": "Automatic Literature Mining", "url": "https://research.bioinformatics.udel.edu/glyco/pmid/16103099" }, { "id": "16103099", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16103099" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 276, "start_aa": "Thr", "end_pos": 276, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr276", "evidence": [ { "id": "O95980", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 297, "start_aa": "Asn", "end_pos": 297, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn297", "evidence": [ { "id": "O95980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95980#ptm_processing" }, { "id": "16103099", "database": "Automatic Literature Mining", "url": "https://research.bioinformatics.udel.edu/glyco/pmid/16103099" }, { "id": "16103099", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16103099" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 352, "start_aa": "Asn", "end_pos": 352, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn352", "evidence": [ { "id": "O95980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95980#ptm_processing" }, { "id": "23090970", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23090970" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" }, { "id": "24190977", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24190977" }, { "id": "16103099", "database": "Automatic Literature Mining", "url": "https://research.bioinformatics.udel.edu/glyco/pmid/16103099" }, { "id": "16103099", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16103099" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 39, "start_aa": "Asn", "end_pos": 39, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn39", "evidence": [ { "id": "O95980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95980#ptm_processing" }, { "id": "16103099", "database": "Automatic Literature Mining", "url": "https://research.bioinformatics.udel.edu/glyco/pmid/16103099" }, { "id": "16103099", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16103099" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 86, "start_aa": "Asn", "end_pos": 86, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn86", "evidence": [ { "id": "O95980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95980#ptm_processing" }, { "id": "16103099", "database": "Automatic Literature Mining", "url": "https://research.bioinformatics.udel.edu/glyco/pmid/16103099" }, { "id": "16103099", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16103099" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan", "glycoprotein_reported" ], "publication": [ { "title": "Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) gene.", "journal": "Biochimica et biophysica acta", "date": "2000", "authors": "Schofield JN, Rademacher TW", "evidence": [ { "database": "Reactome", "id": "R-HSA-163125", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-163125" } ], "reference": [ { "type": "PubMed", "id": "11072085", "url": "https://glygen.org/publication/PubMed/11072085" } ] }, { "title": "Establishment of the genomic structure and identification of thirteen single-nucleotide polymorphisms in the human RECK gene.", "journal": "Cytogenetic and genome research", "date": "2002", "authors": "Eisenberg I, Hochner H, Sadeh M, Argov Z, Mitrani-Rosenbaum S", "evidence": [ { "database": "RefSeq", "id": "NP_066934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066934" } ], "reference": [ { "type": "PubMed", "id": "12438739", "url": "https://glygen.org/publication/PubMed/12438739" } ] }, { "title": "RECK expression in pancreatic cancer: its correlation with lower invasiveness and better prognosis.", "journal": "Clinical cancer research : an official journal of the American Association for Cancer Research", "date": "2003", "authors": "Masui T, Doi R, Koshiba T, Fujimoto K, Tsuji S, Nakajima S, Koizumi M, Toyoda E, Tulachan S, Ito D, Kami K, Mori T, Wada M, Noda M, Imamura M", "evidence": [ { "database": "RefSeq", "id": "NP_066934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066934" } ], "reference": [ { "type": "PubMed", "id": "12738734", "url": "https://glygen.org/publication/PubMed/12738734" } ] }, { "title": "RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines.", "journal": "Cancer research", "date": "2005", "authors": "Simizu S, Takagi S, Tamura Y, Osada H", "evidence": [ { "database": "Automatic Literature Mining", "id": "16103099", "url": "https://research.bioinformatics.udel.edu/glyco/pmid/16103099" } ], "reference": [ { "type": "PubMed", "id": "16103099", "url": "https://glygen.org/publication/PubMed/16103099" } ] }, { "title": "The Kazal motifs of RECK protein inhibit MMP-9 secretion and activity and reduce metastasis of lung cancer cells in vitro and in vivo.", "journal": "Journal of cellular and molecular medicine", "date": "2008", "authors": "Chang CK, Hung WC, Chang HC", "evidence": [ { "database": "UniProtKB", "id": "O95980", "url": "https://www.uniprot.org/uniprot/O95980" } ], "reference": [ { "type": "PubMed", "id": "18194466", "url": "https://glygen.org/publication/PubMed/18194466" } ] }, { "title": "Quantification of the N-glycosylated secretome by super-SILAC during breast cancer progression and in human blood samples.", "journal": "Molecular & cellular proteomics : MCP", "date": "2013", "authors": "Boersema PJ, Geiger T, Wisniewski JR, Mann M", "evidence": [ { "database": "GlyGen", "id": "GLY_000143", "url": "https://data.glygen.org/GLY_000143" } ], "reference": [ { "type": "PubMed", "id": "23090970", "url": "https://glygen.org/publication/PubMed/23090970" } ] }, { "title": "N-linked glycosylation enrichment for in-depth cell surface proteomics of diffuse large B-cell lymphoma subtypes.", "journal": "Molecular & cellular proteomics : MCP", "date": "2014", "authors": "Deeb SJ, Cox J, Schmidt-Supprian M, Mann M", "evidence": [ { "database": "GlyGen", "id": "GLY_000143", "url": "https://data.glygen.org/GLY_000143" } ], "reference": [ { "type": "PubMed", "id": "24190977", "url": "https://glygen.org/publication/PubMed/24190977" } ] }, { "title": "A glycan-phosphatidylinositol-specific phospholipase D in human serum.", "journal": "Science (New York, N.Y.)", "date": "1987", "authors": "Davitz MA, Hereld D, Shak S, Krakow J, Englund PT, Nussenzweig V", "evidence": [ { "database": "Reactome", "id": "R-HSA-163125", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-163125" } ], "reference": [ { "type": "PubMed", "id": "2443973", "url": "https://glygen.org/publication/PubMed/2443973" } ] }, { "title": "Wnt proteins synergize to activate \u03b2-catenin signaling.", "journal": "Journal of cell science", "date": "2017-05-01", "authors": "Alok Anshula, Lei Zhengdeng, Jagannathan N Suhas, Kaur Simran, Harmston Nathan, Rozen Steven G, Tucker-Kellogg Lisa, Virshup David 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"O95980", "url": "" } ], "reference": [ { "type": "PubMed", "id": "30459171", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "title": "A phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1988", "authors": "Low MG, Prasad AR", "evidence": [ { "database": "Reactome", "id": "R-HSA-163125", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-163125" } ], "reference": [ { "type": "PubMed", "id": "3422494", "url": "https://glygen.org/publication/PubMed/3422494" } ] }, { "title": "RECK Variants are Associated with Clinicopathological Features and Decreased Susceptibility in Mexican Patients with Colorectal Cancer.", "journal": "The Tohoku journal of experimental medicine", "date": "2022", "authors": "Maria Marquez-Gonzalez R, Margarita Saucedo-Sarinana A, Barros-Nunez P, Patricia Gallegos-Arreola M, Ibet Juarez-Vazquez C, Daniel Pineda-Razo T, Eugenia Marin-Contreras M, Esperanza Flores-Martinez S, Alejandra Rosales-Reynoso M", "evidence": [ { "database": "RefSeq", "id": "NP_066934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066934" } ], "reference": [ { "type": "PubMed", "id": "35444107", "url": "https://glygen.org/publication/PubMed/35444107" } ] }, { "title": "Mycoplasma pneumoniae downregulates RECK to promote matrix metalloproteinase-9 secretion by bronchial epithelial cells.", "journal": "Virulence", "date": "2022", "authors": "Qin L, Liu L, Wu Y, Chen Y, Wu Y, Luo H, Xi Y, Xiu F, Hu J, Chen L, Wu N, He J, Zeng Y, Zhu C, You X", "evidence": [ { "database": "RefSeq", "id": "NP_066934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066934" } ], "reference": [ { "type": "PubMed", "id": "35892136", "url": "https://glygen.org/publication/PubMed/35892136" } ] }, { "title": "RECK gene polymorphisms in hepatitis B-related hepatocellular carcinoma: A case-control study.", 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"url": "https://www.uniprot.org/uniprot/O95980" } ], "pmid": "" }, { "name": "negative regulation of cell migration", "id": "GO:0030336", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030336", "evidence": [ { "database": "UniProtKB", "id": "O95980", "url": "https://www.uniprot.org/uniprot/O95980" } ], "pmid": "" }, { "name": "embryonic forelimb morphogenesis", "id": "GO:0035115", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035115", "evidence": [ { "database": "UniProtKB", "id": "O95980", "url": "https://www.uniprot.org/uniprot/O95980" } ], "pmid": "" }, { "name": "blood vessel maturation", "id": "GO:0001955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001955", "evidence": [ { "database": "UniProtKB", "id": "O95980", "url": "https://www.uniprot.org/uniprot/O95980" } ], "pmid": "" }, { "name": "canonical Wnt signaling pathway", "id": "GO:0060070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060070", "evidence": [ { "database": "UniProtKB", "id": "O95980", "url": "https://www.uniprot.org/uniprot/O95980" } ], "pmid": "" }, { "name": "sprouting angiogenesis", "id": "GO:0002040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002040", "evidence": [ { "database": "UniProtKB", "id": "O95980", "url": "https://www.uniprot.org/uniprot/O95980" } ], "pmid": "" }, { "name": "regulation of angiogenesis", "id": "GO:0045765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045765", "evidence": [ { "database": "UniProtKB", "id": "O95980", "url": "https://www.uniprot.org/uniprot/O95980" } ], "pmid": "" }, { "name": "regulation of establishment of blood-brain barrier", "id": "GO:0090210", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090210", "evidence": [ { "database": "UniProtKB", "id": "O95980", "url": "https://www.uniprot.org/uniprot/O95980" } ], "pmid": "" }, { "name": "positive regulation of canonical Wnt signaling pathway", "id": "GO:0090263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090263", "evidence": [ { "database": "UniProtKB", "id": "O95980", "url": "https://www.uniprot.org/uniprot/O95980" } ], "pmid": "" }, { "name": "embryo implantation", "id": "GO:0007566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007566", "evidence": [ { "database": "UniProtKB", "id": "O95980", "url": "https://www.uniprot.org/uniprot/O95980" } ], "pmid": "" }, { "name": "negative regulation of metalloendopeptidase activity", "id": "GO:1904684", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904684", "evidence": [ { "database": "UniProtKB", "id": "O95980", "url": "https://www.uniprot.org/uniprot/O95980" } ], "pmid": "" } ] } ] }, "pro_annotation": [ { "name": "reversion-inducing cysteine-rich protein with Kazal motifs O-glycosylated 1 (human)", "definition": "A reversion-inducing cysteine-rich protein with Kazal motifs (human) that has been O-glycosylated at the residue equivalent to Thr-276 of the amino acid sequence represented by UniProtKB:O95980-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O95980-1, Thr-276, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050932", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050932" } ] } ], "site_annotation": [ { "start_pos": 200, "end_pos": 202, "annotation": "n_glycosylation_sequon" }, { "start_pos": 297, "end_pos": 299, "annotation": "n_glycosylation_sequon" }, { "start_pos": 352, "end_pos": 354, "annotation": "n_glycosylation_sequon" }, { "start_pos": 39, "end_pos": 41, "annotation": "n_glycosylation_sequon" }, { "start_pos": 86, "end_pos": 88, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "N-glycosylated.", "evidence": [ { "database": "UniProtKB", "id": "O95980", "url": "https://www.uniprot.org/uniprot/O95980" }, { "database": "PubMed", "id": "9789069", "url": "https://glygen.org/publication/PubMed/9789069" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [ 39, 86, 200, 297, 352 ], "o_linked_sites": [ 276 ], "snv_sites": [ 39, 59, 88, 200, 236, 275, 299, 310, 352, 398, 743, 767, 913 ], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 200, "end_pos": 202 }, { "start_pos": 297, "end_pos": 299 }, { "start_pos": 352, "end_pos": 354 }, { "start_pos": 39, "end_pos": 41 }, { "start_pos": 86, "end_pos": 88 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 5 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 5 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 17 }, { "field": "total_sites", "count": 13 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 13 }, { "field": "total_sites", "count": 9 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 18 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }