{ "uniprot_canonical_ac": "O95236-1", "uniprot_ac": "O95236", "uniprot_id": "APOL3_HUMAN", "mass": { "chemical_mass": 44278.0, "monoisotopic_mass": 44278.0 }, "refseq": { "ac": "NP_055164", "name": "apolipoprotein L3 isoform 2", "summary": "This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055164" }, "gene_names": [ { "name": "APOL3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O95236", "id": "O95236" }, { "name": "APOL3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055164", "id": "NP_055164" }, { "name": "apoL-III; APOLIII; CG121; CG12_1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055164", "id": "NP_055164" } ], "protein_names": [ { "name": "Apolipoprotein L3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O95236" }, { "name": "ApoL-III", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95236" }, { "name": "Apolipoprotein L-III", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95236" }, { "name": "CG12_1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95236" }, { "name": "TNF-inducible protein CG12-1; apolipoprotein L, 3; apolipoprotein L-III", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055164", "id": "NP_055164" }, { "name": "TNF-inducible protein CG12-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95236" }, { "name": "apolipoprotein L3 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055164", "id": "NP_055164" } ], "function": [ { "annotation": "A human apolipoprotein L with detergent-like activity kills intracellular pathogens.", "evidence": [ { "database": "RefSeq", "id": "NP_055164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055164" }, { "database": "PubMed", "id": "34437126", "url": "https://glygen.org/publication/PubMed/34437126" } ] }, { "annotation": "APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin.", "evidence": [ { "database": "RefSeq", "id": "NP_055164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055164" }, { "database": "PubMed", "id": "32187552", "url": "https://glygen.org/publication/PubMed/32187552" } ] }, { "annotation": "APOL3 has been found only in humans and African green monkeys", "evidence": [ { "database": "RefSeq", "id": "NP_055164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055164" }, { "database": "PubMed", "id": "11944986", "url": "https://glygen.org/publication/PubMed/11944986" } ] }, { "annotation": "APOL3 regulates angiogenesis in vitro and functions as a modulator of MAPK and FAK signaling in endothelial cells.", "evidence": [ { "database": "RefSeq", "id": "NP_055164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055164" }, { "database": "PubMed", "id": "30423477", "url": "https://glygen.org/publication/PubMed/30423477" } ] }, { "annotation": "Apolipoprotein L3 enhances CD8+ T cell antitumor immunity of colorectal cancer by promoting LDHA-mediated ferroptosis. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_055164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055164" }, { "database": "PubMed", "id": "36923931", "url": "https://glygen.org/publication/PubMed/36923931" } ] }, { "annotation": "May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.", "evidence": [ { "database": "UniProtKB", "id": "O95236", "url": "https://www.uniprot.org/uniprot/O95236#function" } ] }, { "annotation": "The function of apolipoproteins L (APOLs): relevance for kidney disease, neurotransmission disorders, cancer and viral infection. Review article", "evidence": [ { "database": "RefSeq", "id": "NP_055164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055164" }, { "database": "PubMed", "id": "32530132", "url": "https://glygen.org/publication/PubMed/32530132" } ] }, { "annotation": "This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015].", "evidence": [ { "database": "RefSeq", "id": "NP_055164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055164" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs374947997", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs374947997" }, { "id": "rs374947997", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs374947997" }, { "id": "rs374947997", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs374947997" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 177, "end_pos": 177, "sequence_org": "I", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NGI->NGT).", "chr_id": "22", "chr_pos": "36141879", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I177", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs778043155", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778043155" }, { "id": "rs778043155", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778043155" }, { "id": "rs778043155", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs778043155" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 18, "end_pos": 18, "sequence_org": "I", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (IRS->NRS).", "chr_id": "22", "chr_pos": "36160839", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I18", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O95236", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O95236" } ], "glycoeffect": [], "start_pos": 313, "end_pos": 313, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "Q", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "22", "chr_pos": "36141471", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "R313", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", 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"url": "https://www.uniprot.org/uniprot/O95236-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLGQGWGWEASCFACLIRSCCQVVTFTFPFGFQGISQSLENVSGYYADARLEVGSTQLRTAGSCSHSFKRSFLEKKRFTEEATKYFRERVSPVHLQILLTNNEAWKRFVTAAELPRDEADALYEALKKLRTYAAIEDEYVQQKDEQFREWFLKEFPQVKRKIQESIEKLRALANGIEEVHRGCTISNVVSSSTGAASGIMSLAGLVLAPFTAGTSLALTAAGVGLGAASAVTGITTSIVEHSYTSSAEAEASRLTATSIDRLKVFKEVMRDITPNLLSLLNNYYEATQTIGSEIRAIRQARARARLPVTTWRISAGSGGQAERTIAGTTRAVSRGARILSATTSGIFLALDVVNLVYESKHLHEGAKSASAEELRRQAQELEENLMELTQIYQRLNPCHTH", "length": 402, "header": "sp|O95236-1|APOL3_HUMAN Isoform 1 of Apolipoprotein L3 OS=Homo sapiens OX=9606 GN=APOL3 PE=1 SV=3 CANONICAL=O95236-1" }, "isoforms": [ { "isoform_ac": "A0A8Q3SHV3-1", "url": "", "sequence": { "sequence": "MDSEKKRFTEEATKYFRERVSPVHLQILLTNNEAWKRFVTAAELPRDEADALYEALKKLRTYAAIEDEYVQQKDEQFREWFLKEFPQVKRKIQESIE", "length": 97, "header": "tr|A0A8Q3SHV3-1|APOL3_HUMAN Computationally mapped isoform of Apolipoprotein L3 OS=Homo sapiens OX=9606 GN=APOL3 PE=1 SV=1 CANONICAL=O95236-1" }, "locus": { "chromosome": "22", "start_pos": 36149055, "end_pos": 36141905, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000695564.1", "url": "https://www.ensembl.org/id/ENST00000695564.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000512022.1", "url": "https://www.ensembl.org/id/ENSP00000512022.1" } ] } }, { "isoform_ac": "A0A8Q3SHV8-1", "url": "", "sequence": { "sequence": "MDSEKKRFTEEATKYFRERVSPVHLQILLTNNEAWKRFVTAAELPRDEADALYEALKKLRTYAAIEDEYVQQKDEQFREWFLKEFPQVKRKIQESIEKLRALANGIEEVHR", "length": 111, "header": "tr|A0A8Q3SHV8-1|APOL3_HUMAN Computationally mapped isoform of Apolipoprotein L3 OS=Homo sapiens OX=9606 GN=APOL3 PE=1 SV=1 CANONICAL=O95236-1" }, "locus": { "chromosome": "22", "start_pos": 36149055, "end_pos": 36141863, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000534251.1", "url": "https://www.ensembl.org/id/ENST00000534251.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000512021.1", "url": "https://www.ensembl.org/id/ENSP00000512021.1" } ] } }, { "isoform_ac": "A0A8Q3SHW2-1", "url": "", "sequence": { "sequence": "MDSEKKRFTEEATKYFRERVSPVHLQILLTNNEA", "length": 34, "header": "tr|A0A8Q3SHW2-1|A0A8Q3SHW2_HUMAN Computationally mapped isoform of Apolipoprotein L3 OS=Homo sapiens OX=9606 GN=APOL3 PE=1 SV=1 CANONICAL=O95236-1" }, "locus": { "chromosome": "22", "start_pos": 36149055, "end_pos": 36145508, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000525184.1", "url": "https://www.ensembl.org/id/ENST00000525184.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000512023.1", "url": "https://www.ensembl.org/id/ENSP00000512023.1" } ] } }, { "isoform_ac": "A0A8Q3SI17-1", "url": "", "sequence": { "sequence": "MDSEKKRFTEEATKYFRERVSP", "length": 22, "header": "tr|A0A8Q3SI17-1|A0A8Q3SI17_HUMAN Computationally mapped isoform of Apolipoprotein L3 OS=Homo sapiens OX=9606 GN=APOL3 PE=1 SV=1 CANONICAL=O95236-1" }, "locus": { "chromosome": "22", "start_pos": 36149055, "end_pos": 36145544, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000485453.1", "url": "https://www.ensembl.org/id/ENST00000485453.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000512024.1", "url": "https://www.ensembl.org/id/ENSP00000512024.1" } ] } }, { "isoform_ac": "F2Z2M3-1", "url": "", "sequence": { "sequence": "MGLGQGWGWEASCFACLIRSCCQVVTFTFPFGFQGISQSLENVSGYYADARLEVGSTQLRTAGSCSHSFKRSFLGQKDPALV", "length": 82, "header": "tr|F2Z2M3-1|F2Z2M3_HUMAN Computationally mapped isoform of Apolipoprotein L3 OS=Homo sapiens OX=9606 GN=APOL3 PE=4 SV=1 CANONICAL=O95236-1" }, "locus": { "chromosome": "22", "start_pos": 36160891, "end_pos": 36149349, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000422426.5", "url": "https://www.ensembl.org/id/ENST00000422426.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000409345.1", "url": "https://www.ensembl.org/id/ENSP00000409345.1" } ] } }, { "isoform_ac": "H0YCT0-1", "url": "", "sequence": { "sequence": "SQSLENVSGYYADARLEVGSTQLRTAGSCSHSFKRSFLGE", "length": 40, "header": "tr|H0YCT0-1|APOL3_HUMAN Computationally mapped isoform of Apolipoprotein L3 OS=Homo sapiens OX=9606 GN=APOL3 PE=1 SV=1 CANONICAL=O95236-1" }, "locus": { "chromosome": "22", "start_pos": 36160783, "end_pos": 36154624, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000531095.1", "url": "https://www.ensembl.org/id/ENST00000531095.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000432271.1", "url": "https://www.ensembl.org/id/ENSP00000432271.1" } ] } }, { "isoform_ac": "H0YD32-1", "url": "", "sequence": { "sequence": "MTKGPCLGVRVRAEGAGASRISLNTSWLGPRRLKNTGLGLRKKTNPSSQVSDWRAPWKVSQ", "length": 61, "header": "tr|H0YD32-1|APOL3_HUMAN Computationally mapped isoform of Apolipoprotein L3 OS=Homo sapiens OX=9606 GN=APOL3 PE=1 SV=2 CANONICAL=O95236-1" }, "locus": { "chromosome": "22", "start_pos": 36149772, "end_pos": 36149075, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000472303.1", "url": "https://www.ensembl.org/id/ENST00000472303.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000432868.2", "url": "https://www.ensembl.org/id/ENSP00000432868.2" } ] } }, { "isoform_ac": "H0YDH5-1", "url": "", "sequence": { "sequence": "MDSEKKRFTEEATKYFRERVSPVHLQILLTNNEAWKRFVTAAELPRDEADALYEALKKLRTYAAIEDEYVQQKDEQFREWFLKEFPQVKRKIQESIEKLRALANGIEEVHRGCTISNVVSSSTGAASGIMSLAGLVLAPFTAGTSLALTAAGVGLGAASAVTGITTSIVEHSYTSSAEAEASRLTATSIDRLKVFKEVMRDITPNLLSLLNNYYEATQTIGS", "length": 222, "header": "tr|H0YDH5-1|APOL3_HUMAN Computationally mapped isoform of Apolipoprotein L3 OS=Homo sapiens OX=9606 GN=APOL3 PE=1 SV=2 CANONICAL=O95236-1" }, "locus": { "chromosome": "22", "start_pos": 36149055, "end_pos": 36141530, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000487355.5", "url": "https://www.ensembl.org/id/ENST00000487355.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000433618.2", "url": "https://www.ensembl.org/id/ENSP00000433618.2" } ] } }, { "isoform_ac": "H0YDW3-1", "url": "", "sequence": { "sequence": "MDSDFEDTGVKRLTIGTWQKEAITGIFPVHGEKAWWKAHFLVILS", "length": 45, "header": "tr|H0YDW3-1|APOL3_HUMAN Computationally mapped isoform of Apolipoprotein L3 OS=Homo sapiens OX=9606 GN=APOL3 PE=1 SV=2 CANONICAL=O95236-1" }, "locus": { "chromosome": "22", "start_pos": 36149055, "end_pos": 36146284, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000531195.2", "url": "https://www.ensembl.org/id/ENST00000531195.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000434449.2", "url": "https://www.ensembl.org/id/ENSP00000434449.2" } ] } }, { "isoform_ac": "H0YEQ0-1", "url": "", "sequence": { "sequence": "MDSEKKRFTEEATKYFRERVSPVHLQILLTNNEAWKRFVT", "length": 40, "header": "tr|H0YEQ0-1|H0YEQ0_HUMAN Computationally mapped isoform of Apolipoprotein L3 OS=Homo sapiens OX=9606 GN=APOL3 PE=1 SV=2 CANONICAL=O95236-1" }, "locus": { "chromosome": "22", "start_pos": 36149055, "end_pos": 36145490, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000487783.5", "url": "https://www.ensembl.org/id/ENST00000487783.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000436331.2", "url": "https://www.ensembl.org/id/ENSP00000436331.2" } ] } }, { "isoform_ac": "H7BYQ5-1", "url": "", "sequence": { "sequence": "MGLGQGWGWEASCFACLIRSCCQVVTFTFPFGFQGISQSLENVSGYYADARLEVGSTQLRTAGSCSHSFKRSFLGLRKKTNPSSQVSDWRAPWKVSQ", "length": 97, "header": "tr|H7BYQ5-1|APOL3_HUMAN Computationally mapped isoform of Apolipoprotein L3 OS=Homo sapiens OX=9606 GN=APOL3 PE=1 SV=1 CANONICAL=O95236-1" }, "locus": { "chromosome": "22", "start_pos": 36160891, "end_pos": 36149075, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000397289.6", "url": "https://www.ensembl.org/id/ENST00000397289.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000380457.2", "url": "https://www.ensembl.org/id/ENSP00000380457.2" } ] } }, { "isoform_ac": "H7BZT0-1", "url": "", "sequence": { "sequence": "MESLSVTWLLAPWTQKRNALLKRFVTAAELPRDEADALYEALKKLRTYAAIEDEYVQQKDEQFREWFLKEFPQVKRKIQESIEKLRALANGIEEVHRGCTISNVVSSSTGAASGIMSLAGLVLAPFTAGTSLALTAAGVGLGAASA", "length": 146, "header": "tr|H7BZT0-1|H7BZT0_HUMAN Computationally mapped isoform of Apolipoprotein L3 OS=Homo sapiens OX=9606 GN=APOL3 PE=1 SV=1 CANONICAL=O95236-1" }, "locus": { "chromosome": "22", "start_pos": 36149090, "end_pos": 36141716, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000426939.6", "url": "https://www.ensembl.org/id/ENST00000426939.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000391174.3", "url": "https://www.ensembl.org/id/ENSP00000391174.3" } ] } }, { "isoform_ac": "O95236-1", "url": "", "sequence": { "sequence": "MGLGQGWGWEASCFACLIRSCCQVVTFTFPFGFQGISQSLENVSGYYADARLEVGSTQLRTAGSCSHSFKRSFLEKKRFTEEATKYFRERVSPVHLQILLTNNEAWKRFVTAAELPRDEADALYEALKKLRTYAAIEDEYVQQKDEQFREWFLKEFPQVKRKIQESIEKLRALANGIEEVHRGCTISNVVSSSTGAASGIMSLAGLVLAPFTAGTSLALTAAGVGLGAASAVTGITTSIVEHSYTSSAEAEASRLTATSIDRLKVFKEVMRDITPNLLSLLNNYYEATQTIGSEIRAIRQARARARLPVTTWRISAGSGGQAERTIAGTTRAVSRGARILSATTSGIFLALDVVNLVYESKHLHEGAKSASAEELRRQAQELEENLMELTQIYQRLNPCHTH", "length": 402, "header": "sp|O95236-1|APOL3_HUMAN Isoform 1 of Apolipoprotein L3 OS=Homo sapiens OX=9606 GN=APOL3 PE=1 SV=3 CANONICAL=O95236-1" }, "locus": { "chromosome": "22", "start_pos": 36160891, "end_pos": 36141203, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000349314.6", "url": "https://www.ensembl.org/id/ENST00000349314.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000344577.2", "url": "https://www.ensembl.org/id/ENSP00000344577.2" } ] } }, { "isoform_ac": "O95236-2", "url": "", "sequence": { "sequence": "MDSEKKRFTEEATKYFRERVSPVHLQILLTNNEAWKRFVTAAELPRDEADALYEALKKLRTYAAIEDEYVQQKDEQFREWFLKEFPQVKRKIQESIEKLRALANGIEEVHRGCTISNVVSSSTGAASGIMSLAGLVLAPFTAGTSLALTAAGVGLGAASAVTGITTSIVEHSYTSSAEAEASRLTATSIDRLKVFKEVMRDITPNLLSLLNNYYEATQTIGSEIRAIRQARARARLPVTTWRISAGSGGQAERTIAGTTRAVSRGARILSATTSGIFLALDVVNLVYESKHLHEGAKSASAEELRRQAQELEENLMELTQIYQRLNPCHTH", "length": 331, "header": "sp|O95236-2|APOL3_HUMAN Isoform 2 of Apolipoprotein L3 OS=Homo sapiens OX=9606 GN=APOL3 PE=1 SV=3 CANONICAL=O95236-1" }, "locus": { "chromosome": "22", "start_pos": 36149055, "end_pos": 36141203, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000424878.4", "url": "https://www.ensembl.org/id/ENST00000424878.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000415779.3", "url": "https://www.ensembl.org/id/ENSP00000415779.3" } ] } }, { "isoform_ac": "O95236-3", "url": "", "sequence": { "sequence": "MSLAGLVLAPFTAGTSLALTAAGVGLGAASAVTGITTSIVEHSYTSSAEAEASRLTATSIDRLKVFKEVMRDITPNLLSLLNNYYEATQTIGSEIRAIRQARARARLPVTTWRISAGSGGQAERTIAGTTRAVSRGARILSATTSGIFLALDVVNLVYESKHLHEGAKSASAEELRRQAQELEENLMELTQIYQRLNPCHTH", "length": 202, "header": "sp|O95236-3|APOL3_HUMAN Isoform 3 of Apolipoprotein L3 OS=Homo sapiens OX=9606 GN=APOL3 PE=1 SV=3 CANONICAL=O95236-1" }, "locus": { "chromosome": "22", "start_pos": 36141808, "end_pos": 36141203, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000397293.6", "url": "https://www.ensembl.org/id/ENST00000397293.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000380461.3", "url": "https://www.ensembl.org/id/ENSP00000380461.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 330, "start_aa": "Thr", "end_pos": 330, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr330", "evidence": [ { "id": "O95236", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95236" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "O95236", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O95236" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes.", "journal": "Blood", "date": "1999", "authors": "Horrevoets A J, Fontijn R D, van Zonneveld A J, de Vries C J, ten Cate J W, Pannekoek H", "evidence": [ { "database": "UniProtKB", "id": "O95236", "url": "https://www.uniprot.org/uniprot/O95236" } ], "reference": [ { "type": "PubMed", "id": "10233894", "url": "https://glygen.org/publication/PubMed/10233894" } ] }, { "title": "Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene.", "journal": "J. Lipid Res.", "date": "2001", "authors": "Duchateau P N, Pullinger C R, Cho M H, Eng C, Kane J P", "evidence": [ { "database": "UniProtKB", "id": "O95236", "url": "https://www.uniprot.org/uniprot/O95236" } ], "reference": [ { "type": "PubMed", "id": "11290834", "url": "https://glygen.org/publication/PubMed/11290834" } ] }, { "title": "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution.", "journal": "Genomics", "date": "2001", "authors": "Page NM, Butlin DJ, Lomthaisong K, Lowry PJ", "evidence": [ { "database": "UniProtKB", "id": "O95236", "url": "https://www.uniprot.org/uniprot/O95236" } ], "reference": [ { "type": "PubMed", "id": "11374903", "url": "https://glygen.org/publication/PubMed/11374903" } ] }, { "title": "The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue.", "journal": "Genomics", "date": "2002", "authors": "Monajemi H, Fontijn RD, Pannekoek H, Horrevoets AJ", "evidence": [ { "database": "RefSeq", "id": "NP_055164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055164" } ], "reference": [ { "type": "PubMed", "id": "11944986", "url": "https://glygen.org/publication/PubMed/11944986" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95236", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95236" }, { "database": "O-GlcNAc Atlas", "id": "O95236", "url": "https://oglcnac.org/atlas/detail/O95236" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Apoliporotein L3 interferes with endothelial tube formation via regulation of ERK1/2, FAK and Akt signaling pathway.", "journal": "Atherosclerosis", "date": "2018", "authors": "Khalil A, Poelvoorde P, Fayyad-Kazan M, Rousseau A, Nuyens V, Uzureau S, Biston P, El-Makhour Y, Badran B, Van Antwerpen P, Boudjeltia KZ, Vanhamme L", "evidence": [ { "database": "RefSeq", "id": "NP_055164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055164" } ], "reference": [ { "type": "PubMed", "id": "30423477", "url": "https://glygen.org/publication/PubMed/30423477" } ] }, { "title": "APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin.", "journal": "Cell reports", "date": "2020", "authors": "Uzureau S, Lecordier L, Uzureau P, Hennig D, Graversen JH, Homble F, Mfutu PE, Oliveira Arcolino F, Ramos AR, La Rovere RM, Luyten T, Vermeersch M, Tebabi P, Dieu M, Cuypers B, Deborggraeve S, Rabant M, Legendre C, Moestrup SK, Levtchenko E, Bultynck G, Erneux C, Perez-Morga D, Pays E", "evidence": [ { "database": "RefSeq", "id": "NP_055164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055164" } ], "reference": [ { "type": "PubMed", "id": "32187552", "url": "https://glygen.org/publication/PubMed/32187552" } ] }, { "title": "The function of apolipoproteins L (APOLs): relevance for kidney disease, neurotransmission disorders, cancer and viral infection.", "journal": "The FEBS journal", "date": "2021", "authors": "Pays E", "evidence": [ { "database": "RefSeq", "id": "NP_055164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055164" } ], "reference": [ { "type": "PubMed", "id": "32530132", "url": "https://glygen.org/publication/PubMed/32530132" } ] }, { "title": "A human apolipoprotein L with detergent-like activity kills intracellular pathogens.", "journal": "Science (New York, N.Y.)", "date": "2021", "authors": "Gaudet RG, Zhu S, Halder A, Kim BH, Bradfield CJ, Huang S, Xu D, Maminska A, Nguyen TN, Lazarou M, Karatekin E, Gupta K, MacMicking JD", "evidence": [ { "database": "RefSeq", "id": "NP_055164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055164" } ], "reference": [ { "type": "PubMed", "id": "34437126", "url": "https://glygen.org/publication/PubMed/34437126" } ] }, { "title": "Apolipoprotein L3 enhances CD8+ T cell antitumor immunity of colorectal cancer by promoting LDHA-mediated ferroptosis.", "journal": "International journal of biological sciences", "date": "2023", "authors": "Lv Yang, Tang WenTao, Xu YuQiu, Chang WenJu, Zhang ZhiYuan, Lin Qi, Ji MeiLing, Feng QingYang, He GuoDong, Xu JianMin", "evidence": [ { "database": "RefSeq", "id": "NP_055164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055164" } ], "reference": [ { "type": "PubMed", "id": "36923931", "url": "https://glygen.org/publication/PubMed/36923931" } ] } ], "pathway": [ { "id": "hsa:80833", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:80833", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AP14-1", "protein_name": "Apolipoprotein L, 3", "gene_name": "Apol3l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "FSPQVLRKQFIQDVTEYLQDTVSKKDLQLLLTKDEAWKVFVAEAELSRDEEASLHEALKLLLKLPTWEDKVRLQKELQDRKKFVEAFPQLKRKLQENIRKLRALADHLDQVHKGCTISNVVTNSTSAASGVLSILGLALAPVTAGGSLLLSATGLGLGTVATVTGAATEIVEQTNKWLDEAEARRLLSDTMDTLNTALVLGQKALKLSKKAYDVIKQLKSLGQHIRAIRVARANPRLLADAKRLMTSGRLSAPRASQVQNAFEGTALAMTKKARIRGVATAGVFLAMDVYFLVRDSMDLCDGAKSESGNKLRALAQELEEKLKEVAQIYKSLLVPY", "length": 336 }, "evidence": [ { "id": "O95236", "url": "https://omabrowser.org/oma/group/O95236/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "A2VDH7-1", "protein_name": "Apolipoprotein L 8", "gene_name": "Apol8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDPSDCEDAPGDRTFIEEAAEYLQHTSGREDLRLLLTEDGAWEAFVAEAELSRADADTLRDALHALTANLAVEDQERLQRDLQDMERFMDAFPQVKLELEGHIGKLRTLADKVDKVHRDCTISKLVAGSTSTVSGILTLLGLTLVPVTAGISLVLLATGMGLGAAAAVTSVSSGIVDYTSRSLAKTEASHLVSTGMAKVKMVADAVVHSGPQVLSLSENCCRVLRCIEQSIYAIKLTKANPALAASAMGSTSAQSGKHVKKAFKGTALAISRRARIMGIATAGVSLVGDVISLVKQSKNLHKGTKAKSAEELRQQARELEEKLEALIQMYEGLQAGSRR", "length": 339 }, "evidence": [ { "id": "45929558", "url": "http://www.informatics.jax.org/homology/45929558", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "M0RBH1-1", "protein_name": "Apolipoprotein L, 2", "gene_name": "Apol2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MECLGVPSVHAELGRIGNGSEVCFLLLAAWGRDPAFDTMDPSDGEDSPASRTFIEEATEYLQHTSGRDDLKLLLTEDGAWEAFVAEAELSRADADTLRDALNALTANMAEEDQNRLQHDLQDVERFIDVFPQVKLELERHVRKLRTLADKVDKVHRDCTISKVVAGSTSTVSGVLTLLGLALVPVTAGVSLVLLATGMGLGAAAAVTSVSTGIVDYTSKSSAQTEASHLVSTSMVKVKMAAEAVVYSGPQVFSLSESCCRVLRCIEQSVYAIKLTKANPALAASVKRLMTVGSISAQSDKHVKKAFKGTALAMSRRTRIMGIATAGVSLIGDVISLVKESKNLYKGAKAKSAEELRQQARELEEKLEVLVQIYDGLQSGSTQSS", "length": 384 }, "evidence": [ { "id": "45929558", "url": "http://www.informatics.jax.org/homology/45929558", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "O14791-1", "protein_name": "Apolipoprotein L1", "gene_name": "APOL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGAALLRVSVLCIWMSALFLGVGVRAEEAGARVQQNVPSGTDTGDPQSKPLGDWAAGTMDPESSIFIEDAIKYFKEKVSTQNLLLLLTDNEAWNGFVAAAELPRNEADELRKALDNLARQMIMKDKNWHDKGQQYRNWFLKEFPRLKSELEDNIRRLRALADGVQKVHKGTTIANVVSGSLSISSGILTLVGMGLAPFTEGGSLVLLEPGMELGITAALTGITSSTMDYGKKWWTQAQAHDLVIKSLDKLKEVREFLGENISNFLSLAGNTYQLTRGIGKDIRALRRARANLQSVPHASASRPRVTEPISAESGEQVERVNEPSILEMSRGVKLTDVAPVSFFLVLDVVYLVYESKHLHEGAKSETAEELKKVAQELEEKLNILNNNYKILQADQEL", "length": 398 }, "evidence": [ { "id": "45929558", "url": "http://www.informatics.jax.org/homology/45929558", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9BPW4-1", "protein_name": "Apolipoprotein L4", "gene_name": "APOL4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGAALLKIFVVCIWVQQNHPGWTVAGQFQEKKRFTEEVIEYFQKKVSPVHLKILLTSDEAWKRFVRVAELPREEADALYEALKNLTPYVAIEDKDMQQKEQQFREWFLKEFPQIRWKIQESIERLRVIANEIEKVHRGCVIANVVSGSTGILSVIGVMLAPFTAGLSLSITAAGVGLGIASATAGIASSIVENTYTRSAELTASRLTATSTDQLEALRDILRDITPNVLSFALDFDEATKMIANDVHTLRRSKATVGRPLIAWRYVPINVVETLRTRGAPTRIVRKVARNLGKATSGVLVVLDVVNLVQDSLDLHKGAKSESAESLRQWAQELEENLNELTHIHQSLKAG", "length": 351 }, "evidence": [ { "id": "45929558", "url": "http://www.informatics.jax.org/homology/45929558", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9BQE5-1", "protein_name": "Apolipoprotein L2", "gene_name": "APOL2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNPESSIFIEDYLKYFQDQVSRENLLQLLTDDEAWNGFVAAAELPRDEADELRKALNKLASHMVMKDKNRHDKDQQHRQWFLKEFPRLKRELEDHIRKLRALAEEVEQVHRGTTIANVVSNSVGTTSGILTLLGLGLAPFTEGISFVLLDTGMGLGAAAAVAGITCSVVELVNKLRARAQARNLDQSGTNVAKVMKEFVGGNTPNVLTLVDNWYQVTQGIGRNIRAIRRARANPQLGAYAPPPHVIGRISAEGGEQVERVVEGPAQAMSRGTMIVGAATGGILLLLDVVSLAYESKHLLEGAKSESAEELKKRAQELEGKLNFLTKIHEMLQPGQDQ", "length": 337 }, "evidence": [ { "id": "45929558", "url": "http://www.informatics.jax.org/homology/45929558", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "O95236", "url": "https://www.uniprot.org/uniprot/O95236" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O95236", "url": "https://www.uniprot.org/uniprot/O95236" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "O95236", "url": "https://www.uniprot.org/uniprot/O95236" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "lipid transport", "id": "GO:0006869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "database": "UniProtKB", "id": "O95236", "url": "https://www.uniprot.org/uniprot/O95236" } ], "pmid": "" }, { "name": "lipoprotein metabolic process", "id": "GO:0042157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042157", "evidence": [ { "database": "UniProtKB", "id": "O95236", "url": "https://www.uniprot.org/uniprot/O95236" } ], "pmid": "" }, { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "O95236", "url": "https://www.uniprot.org/uniprot/O95236" } ], "pmid": "" }, { "name": "positive regulation of canonical NF-kappaB signal transduction", "id": "GO:0043123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043123", "evidence": [ { "database": "UniProtKB", "id": "O95236", "url": "https://www.uniprot.org/uniprot/O95236" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "O95236", "url": "https://www.uniprot.org/uniprot/O95236" } ], "pmid": "" }, { "name": "lipid transporter activity", "id": "GO:0005319", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005319", "evidence": [ { "database": "UniProtKB", "id": "O95236", "url": "https://www.uniprot.org/uniprot/O95236" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 330 ], "snv_sites": [ 18, 177, 313, 330, 339, 387 ], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 42, "end_pos": 44 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 10 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }