{ "uniprot_canonical_ac": "O95006-1", "uniprot_ac": "O95006", "uniprot_id": "OR2F2_HUMAN", "mass": { "chemical_mass": 35294.0, "monoisotopic_mass": 35294.0 }, "refseq": { "ac": "NP_001004685", "name": "olfactory receptor 2F2", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004685" }, "gene_names": [ { "name": "OR2F2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O95006", "id": "O95006" }, { "name": "OR2F2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004685", "id": "NP_001004685" }, { "name": "OR7-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004685", "id": "NP_001004685" } ], "protein_names": [ { "name": "Olfactory receptor 2F2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O95006" }, { "name": "OR7-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95006" }, { "name": "Olfactory receptor 7-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95006" }, { "name": "Olfactory receptor OR7-6", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95006" }, { "name": "olfactory receptor 2F2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004685", "id": "NP_001004685" }, { "name": "olfactory receptor OR7-6; olfactory receptor 7-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004685", "id": "NP_001004685" } ], "function": [ { "annotation": "Observational study of gene-disease association. (HuGE Navigator)", "evidence": [ { "database": "RefSeq", "id": "NP_001004685", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004685" }, { "database": "PubMed", "id": "20855565", "url": "https://glygen.org/publication/PubMed/20855565" } ] }, { "annotation": "Odorant receptor.", "evidence": [ { "database": "UniProtKB", "id": "O95006", "url": "https://www.uniprot.org/uniprot/O95006#function" } ] }, { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. 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"MEIDNQTWVREFILLGLSSDWCTQISLFSLFLVTYLMTVLGNCLIVLLIRLDSRLHTPMYFFLTNLSLVDVSYATSVVPQLLAHFLAEHKAIPFQSCAAQLFFSLALGGIEFVLLAVMAYDRHVAVSDRLRYSAIMHGGLCARLAITSWVSGSINSLVQTAITFQLPMCTNKFIDHISCELLAVVRLACVDTSSNEAAIMVSSIVLLMTPFCLVLLSYIRIISTILKIQSREGRKKAFHTCASHLTVVALCYGTTIFTYIQPHSGPSVLQEKLISVFYAIVMPLLNPVIYSLRNKEVKGAWHKLLEKFSGLTSKLGT", "length": 317, "header": "sp|O95006-1|OR2F2_HUMAN Isoform 1 of Olfactory receptor 2F2 OS=Homo sapiens OX=9606 GN=OR2F2 PE=2 SV=1 CANONICAL=O95006-1" }, "isoforms": [ { "isoform_ac": "O95006-1", "url": "", "sequence": { "sequence": "MEIDNQTWVREFILLGLSSDWCTQISLFSLFLVTYLMTVLGNCLIVLLIRLDSRLHTPMYFFLTNLSLVDVSYATSVVPQLLAHFLAEHKAIPFQSCAAQLFFSLALGGIEFVLLAVMAYDRHVAVSDRLRYSAIMHGGLCARLAITSWVSGSINSLVQTAITFQLPMCTNKFIDHISCELLAVVRLACVDTSSNEAAIMVSSIVLLMTPFCLVLLSYIRIISTILKIQSREGRKKAFHTCASHLTVVALCYGTTIFTYIQPHSGPSVLQEKLISVFYAIVMPLLNPVIYSLRNKEVKGAWHKLLEKFSGLTSKLGT", "length": 317, "header": "sp|O95006-1|OR2F2_HUMAN Isoform 1 of Olfactory receptor 2F2 OS=Homo sapiens OX=9606 GN=OR2F2 PE=2 SV=1 CANONICAL=O95006-1" }, "locus": { "chromosome": "7", "start_pos": 143936183, "end_pos": 143935233, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000408955.3", "url": "https://www.ensembl.org/id/ENST00000408955.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000386222.2", "url": "https://www.ensembl.org/id/ENSP00000386222.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 5, "start_aa": "Asn", "end_pos": 5, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn5", "evidence": [ { "id": "O95006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95006#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "The human olfactory receptor gene family.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2004", "authors": "Malnic B, Godfrey PA, Buck LB", "evidence": [ { "database": "UniProtKB", "id": "O95006", "url": "https://www.uniprot.org/uniprot/O95006" } ], "reference": [ { "type": "PubMed", "id": "14983052", "url": "https://glygen.org/publication/PubMed/14983052" } ] }, { "title": "Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease.", "journal": "Journal of lipid research", "date": "2010", "authors": "Peloso GM, Demissie S, Collins D, Mirel DB, Gabriel SB, Cupples LA, Robins SJ, Schaefer EJ, Brousseau ME", "evidence": [ { "database": "RefSeq", "id": "NP_001004685", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004685" } ], "reference": [ { "type": "PubMed", "id": "20855565", "url": "https://glygen.org/publication/PubMed/20855565" } ] }, { "title": "Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing.", "journal": "Cell", "date": "2012", "authors": "Imielinski M, Berger AH, Hammerman PS, Hernandez B, Pugh TJ, Hodis E, Cho J, Suh J, Capelletti M, Sivachenko A, Sougnez C, Auclair D, Lawrence MS, Stojanov P, Cibulskis K, Choi K, de Waal L, Sharifnia T, Brooks A, Greulich H, Banerji S, Zander T, Seidel D, Leenders F, Ansen S, Ludwig C, Engel-Riedel W, Stoelben E, Wolf J, Goparju C, Thompson K, Winckler W, Kwiatkowski D, Johnson BE, Janne PA, Miller VA, Pao W, Travis WD, Pass HI, Gabriel SB, Lander ES, Thomas RK, Garraway LA, Getz G, Meyerson M", "evidence": [ { "database": "dbSNP", "id": "rs749732316", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs749732316" } ], "reference": [ { "type": "PubMed", "id": "22980975", "url": "https://glygen.org/publication/PubMed/22980975" } ] }, { "title": "Profiling of olfactory receptor gene expression in whole human olfactory mucosa.", "journal": "PloS one", "date": "2014", "authors": "Verbeurgt C, Wilkin F, Tarabichi M, Gregoire F, Dumont JE, Chatelain P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9752946", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9752946" } ], "reference": [ { "type": "PubMed", "id": "24800820", "url": "https://glygen.org/publication/PubMed/24800820" } ] }, { "title": "The human olfactory transcriptome.", "journal": "BMC genomics", "date": "2016", "authors": "Olender T, Keydar I, Pinto JM, Tatarskyy P, Alkelai A, Chien MS, Fishilevich S, Restrepo D, Matsunami H, Gilad Y, Lancet D", "evidence": [ { "database": "Reactome", "id": "R-HSA-9752946", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9752946" } ], "reference": [ { "type": "PubMed", "id": "27515280", "url": "https://glygen.org/publication/PubMed/27515280" } ] }, { "title": "Structural instability and divergence from conserved residues underlie intracellular retention of mammalian odorant receptors.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2020", "authors": "Ikegami K, de March CA, Nagai MH, Ghosh S, Do M, Sharma R, Bruguera ES, Lu YE, Fukutani Y, Vaidehi N, Yohda M, Matsunami H", "evidence": [ { "database": "Reactome", "id": "R-HSA-9752946", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9752946" } ], "reference": [ { "type": "PubMed", "id": "31974307", "url": "https://glygen.org/publication/PubMed/31974307" } ] }, { "title": "Single-cell analysis of olfactory neurogenesis and differentiation in adult humans.", "journal": "Nature neuroscience", "date": "2020", "authors": "Durante MA, Kurtenbach S, Sargi ZB, Harbour JW, Choi R, Kurtenbach S, Goss GM, Matsunami H, Goldstein BJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9752946", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9752946" } ], "reference": [ { "type": "PubMed", "id": "32066986", "url": "https://glygen.org/publication/PubMed/32066986" } ] } ], "pathway": [ { "id": "hsa:135948", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:135948", "resource": "KEGG Pathway" }, { "id": "R-HSA-9752946", "name": "Expression and translocation of olfactory receptors", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9752946", "resource": "Reactome", "description": "Expression and translocation of olfactory receptors" } ], "orthologs": [ { "uniprot_canonical_ac": "D4AAR1-1", "protein_name": "Olfactory receptor", "gene_name": "Or2f2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEQDNQTWVHEFILLGLSSDWNTQVSLFILFLLMYLLTVLGNFLIILLIRLDSRLHTPMYFFLNNLSLVDVSYATSIVPQLLAHFLATRKAIPFLSCAAQLFFSLGLGGIEFLLLAVMAYDRYVAVCDPLRYSVIMHTGLCTRLVITSWVSGSLNSLVHTAITFQLPMCTNKYIDHISCEILAVVRLACVDTSSNEIVIMVSSIVLLMTPFFLVLLSYIQIISTILKIQSTEGRRKAFHTCASHLTVVTLCYGTTIFTYIQPHSSPSVLQEKLISLFYAILMPMLNPMIYSLRNKEVKGAWQKLLGNLSGFTSKLTSG", "length": 318 }, "evidence": [ { "id": "45935296", "url": "http://www.informatics.jax.org/homology/45935296", "database": "MGI" }, { "id": "O95006", "url": "https://omabrowser.org/oma/group/O95006/", "database": "OMA" } 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