{ "uniprot_canonical_ac": "O75449-1", "uniprot_ac": "O75449", "uniprot_id": "KTNA1_HUMAN", "mass": { "chemical_mass": 55965.0, "monoisotopic_mass": 55965.0 }, "refseq": { "ac": "NP_001191005", "name": "katanin p60 ATPase-containing subunit A1 isoform 2", "summary": "Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191005" }, "gene_names": [ { "name": "KATNA1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O75449", "id": "O75449" }, { "name": "KATNA1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191005", "id": "NP_001191005" } ], "protein_names": [ { "name": "Katanin p60 ATPase-containing subunit A1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O75449" }, { "name": "5.6.1.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75449" }, { "name": "Katanin p60 subunit A1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75449" }, { "name": "katanin p60 ATPase-containing subunit A1 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191005", "id": "NP_001191005" }, { "name": "p60 katanin; katanin p60 subunit A1; katanin p60 (ATPase containing) subunit A 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191005", "id": "NP_001191005" }, { "name": "p60 katanin", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75449" } ], "function": [ { "annotation": "A chemical genetics approach to examine the functions of AAA proteins.", "evidence": [ { "database": "RefSeq", "id": "NP_001191005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191005" }, { "database": "PubMed", "id": "33782614", "url": "https://glygen.org/publication/PubMed/33782614" } ] }, { "annotation": "Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449#function" }, { "database": "UniProtKB", "id": "MF_03023", "url": "https://www.uniprot.org/uniprot/MF_03023#function" }, { "database": "PubMed", "id": "19287380", "url": "https://glygen.org/publication/PubMed/19287380" }, { "database": "PubMed", "id": "10751153", "url": "https://glygen.org/publication/PubMed/10751153" }, { "database": "PubMed", "id": "11870226", "url": "https://glygen.org/publication/PubMed/11870226" } ] }, { "annotation": "In this study, we identified the main regulatory region of KATNA1 gene encoding katanin-p60 as 5' UTR, which has a key role for its expression, and showed Elk1 binding to KATNA1. Furthermore, we identified that Elk1 decreased katanin-p60 and spastin protein expressions, while mRNA levels were increased upon Elk1 overexpression. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001191005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191005" }, { "database": "PubMed", "id": "30789974", "url": "https://glygen.org/publication/PubMed/30789974" } ] }, { "annotation": "Katanin P60 and P80 in papillary thyroid carcinoma patients: Indicators for exacerbated tumor features and worse disease-free survival.", "evidence": [ { "database": "RefSeq", "id": "NP_001191005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191005" }, { "database": "PubMed", "id": "33274499", "url": "https://glygen.org/publication/PubMed/33274499" } ] }, { "annotation": "Katanin P60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001191005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191005" }, { "database": "PubMed", "id": "32631334", "url": "https://glygen.org/publication/PubMed/32631334" } ] }, { "annotation": "Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011].", "evidence": [ { "database": "RefSeq", "id": "NP_001191005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191005" } ] }, { "annotation": "SUMOylation of microtubule-cleaving enzyme KATNA1 promotes microtubule severing and neurite outgrowth.", "evidence": [ { "database": "RefSeq", "id": "NP_001191005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191005" }, { "database": "PubMed", "id": "35868557", "url": "https://glygen.org/publication/PubMed/35868557" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs1023782706", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1023782706" }, { "id": "rs1023782706", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1023782706" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 130, "end_pos": 130, "sequence_org": "P", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NRP->NRS).", "chr_id": "6", "chr_pos": "149623216", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P130", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1434375435", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1434375435" }, { "id": "rs1434375435", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1434375435" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 131, "end_pos": 131, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (STT->NTT).", "chr_id": "6", "chr_pos": "149623212", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S131", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O75449", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O75449" }, { "id": "rs1193519113", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1193519113" }, { "id": "rs1193519113", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1193519113" }, { "id": "rs1193519113", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1193519113" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 362, "end_pos": 362, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "P", "sequence_mut": "S", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (NFP->NFS).", "chr_id": "6", "chr_pos": "149597573", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "P362", "disease": [ { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] }, { "evidence": [ { "id": "rs1297804127", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1297804127" }, { "id": "rs1297804127", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1297804127#frequency_tab" }, { "id": "rs1297804127", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1297804127" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 79, "end_pos": 79, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DST->NST).", "chr_id": "6", "chr_pos": "149632844", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D79", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [ { "start_pos": 255, "end_pos": 255, "sequence_org": "K", "sequence_mut": "A", "comment": "Abolishes ATP dependent microtubule severing activity and localization to spindle poles.", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" }, { "database": "PubMed", "id": "10751153", "url": "https://glygen.org/publication/PubMed/10751153" }, { "database": "PubMed", "id": "11870226", "url": "https://glygen.org/publication/PubMed/11870226" } ] }, { "start_pos": 308, "end_pos": 308, "sequence_org": "D", "sequence_mut": "N", "comment": "Abolishes ATP dependent microtubule severing activity and localization to spindle poles; when associated with N-309.", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" }, { "database": "PubMed", "id": "10751153", "url": "https://glygen.org/publication/PubMed/10751153" } ] }, { "start_pos": 309, "end_pos": 309, "sequence_org": "E", "sequence_mut": "N", "comment": "Abolishes ATP dependent microtubule severing activity and localization to spindle poles; when associated with N-308.", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" }, { "database": "PubMed", "id": "10751153", "url": "https://glygen.org/publication/PubMed/10751153" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "79.81", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000186625", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186625" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "81.11", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000186625", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186625" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "79.78", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000186625", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186625" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "65.26", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000186625", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186625" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "88.96", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000186625", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186625" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "86.78", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000186625", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186625" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "72.38", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000186625", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186625" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "85.89", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000186625", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186625" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "85.07", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000186625", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186625" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "74.53", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000186625", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186625" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "79.01", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000186625", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186625" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "84.99", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000186625", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186625" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "85.52", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000186625", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000186625" } ] } ], "expression_disease": [ { "significant": "No", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O75449", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75449" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { 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"MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O75449", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75449" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", 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"name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { 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}, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O75449", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75449" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75449" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "O75449", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75449" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", 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"https://www.ebi.ac.uk/intact/interactors/id:B7ZBC8*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "O75449", "url": "https://www.ebi.ac.uk/intact/interactors/id:O75449*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003959", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003959", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003960", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003960", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015415", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015415", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028596", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028596", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041569", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041569", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048612", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048612", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:11104", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:11104", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "606696", "url": "http://www.omim.org/entry/606696", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O75449", "url": "https://www.nextprot.org/entry/NX_O75449", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "O75449", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75449", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "PRDEMHM", "url": "https://omabrowser.org/oma/group/PRDEMHM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "276256at2759", "url": "http://www.orthodb.org/?query=276256at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23074", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23074", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23074:SF71", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23074:SF71", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "5ZQL", "url": "https://www.rcsb.org/structure/5ZQL", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5ZQM", "url": "https://www.rcsb.org/structure/5ZQM", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00004", "url": "http://pfam.xfam.org/family/PF00004", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF09336", "url": "http://pfam.xfam.org/family/PF09336", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF17862", "url": "http://pfam.xfam.org/family/PF17862", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF21126", "url": "http://pfam.xfam.org/family/PF21126", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O75449", "url": "https://pharos.nih.gov/targets/O75449", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O75449", "url": "http://purl.obolibrary.org/obo/PR_O75449", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001191005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191005", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "B7ZBC8", "url": "https://www.uniprot.org/uniprot/B7ZBC8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B7ZBC8-1", "url": "https://www.uniprot.org/uniprot/B7ZBC8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B7ZBC9", "url": "https://www.uniprot.org/uniprot/B7ZBC9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B7ZBC9-1", "url": "https://www.uniprot.org/uniprot/B7ZBC9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75449-1", "url": "https://www.uniprot.org/uniprot/O75449-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75449-2", "url": "https://www.uniprot.org/uniprot/O75449-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQHDLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIFEFGSC", "length": 491, "header": "sp|O75449-1|KTNA1_HUMAN Isoform 1 of Katanin p60 ATPase-containing subunit A1 OS=Homo sapiens OX=9606 GN=KATNA1 PE=1 SV=1 CANONICAL=O75449-1" }, "isoforms": [ { "isoform_ac": "B7ZBC8-1", "url": "", "sequence": { "sequence": "MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQHDLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTS", "length": 280, "header": "tr|B7ZBC8-1|KTNA1_HUMAN Computationally mapped isoform of Katanin p60 ATPase-containing subunit A1 OS=Homo sapiens OX=9606 GN=KATNA1 PE=1 SV=1 CANONICAL=O75449-1" }, "locus": { "chromosome": "6", "start_pos": 149638547, "end_pos": 149601642, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000444282.5", "url": "https://www.ensembl.org/id/ENST00000444282.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000390322.1", "url": "https://www.ensembl.org/id/ENSP00000390322.1" } ] } }, { "isoform_ac": "B7ZBC9-1", "url": "", "sequence": { "sequence": "MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQHDLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDI", "length": 211, "header": "tr|B7ZBC9-1|KTNA1_HUMAN Computationally mapped isoform of Katanin p60 ATPase-containing subunit A1 OS=Homo sapiens OX=9606 GN=KATNA1 PE=1 SV=1 CANONICAL=O75449-1" }, "locus": { "chromosome": "6", "start_pos": 149638547, "end_pos": 149603364, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000420200.1", "url": "https://www.ensembl.org/id/ENST00000420200.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000398993.1", "url": "https://www.ensembl.org/id/ENSP00000398993.1" } ] } }, { "isoform_ac": "O75449-1", "url": "", "sequence": { "sequence": "MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQHDLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIFEFGSC", "length": 491, "header": "sp|O75449-1|KTNA1_HUMAN Isoform 1 of Katanin p60 ATPase-containing subunit A1 OS=Homo sapiens OX=9606 GN=KATNA1 PE=1 SV=1 CANONICAL=O75449-1" }, "locus": { "chromosome": "6", "start_pos": 149638547, "end_pos": 149595039, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000335647.9", "url": "https://www.ensembl.org/id/ENST00000335647.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000335106.5", "url": "https://www.ensembl.org/id/ENSP00000335106.5" } ] } }, { "isoform_ac": "O75449-2", "url": "", "sequence": { "sequence": "MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQHDLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSGMRP", "length": 311, "header": "sp|O75449-2|KTNA1_HUMAN Isoform 2 of Katanin p60 ATPase-containing subunit A1 OS=Homo sapiens OX=9606 GN=KATNA1 PE=1 SV=1 CANONICAL=O75449-1" }, "locus": { "chromosome": "6", "start_pos": 149638547, "end_pos": 149595224, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000335643.12", "url": "https://www.ensembl.org/id/ENST00000335643.12" }, { "database": "Ensembl Peptide", "id": "ENSP00000335180.8", "url": "https://www.ensembl.org/id/ENSP00000335180.8" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 359, "start_aa": "Thr", "end_pos": 359, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr359", "evidence": [ { "id": "O75449", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75449" }, { "id": "36240223", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36240223" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 9, "start_aa": "Asn", "end_pos": 9, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn9", "evidence": [ { "id": "24190977", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24190977" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" } ] } ], "phosphorylation": [ { "start_pos": 109, "end_pos": 109, "kinase_uniprot_canonical_ac": "Q92630-1", "kinase_gene_name": "DYRK2", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O75449", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75449" }, { "database": "PubMed", "id": "19287380", "url": "https://glygen.org/publication/PubMed/19287380" } ], "site_lbl": "Ser109" }, { "start_pos": 109, "end_pos": 109, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by DYRK2", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" }, { "database": "iPTMnet", "id": "O75449", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75449" }, { "database": "PubMed", "id": "19287380", "url": "https://glygen.org/publication/PubMed/19287380" } ], "site_lbl": "Ser109" }, { "start_pos": 133, "end_pos": 133, "kinase_uniprot_canonical_ac": "Q92630-1", "kinase_gene_name": "DYRK2", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O75449", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75449" }, { "database": "PubMed", "id": "19287380", "url": "https://glygen.org/publication/PubMed/19287380" } ], "site_lbl": "Thr133" }, { "start_pos": 133, "end_pos": 133, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine; by DYRK2", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" }, { "database": "iPTMnet", "id": "O75449", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75449" }, { "database": "PubMed", "id": "19287380", "url": "https://glygen.org/publication/PubMed/19287380" } ], "site_lbl": "Thr133" }, { "start_pos": 170, "end_pos": 170, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "iPTMnet", "id": "O75449", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75449" }, { "database": "PubMed", "id": "19007248", "url": "https://glygen.org/publication/PubMed/19007248" }, { "database": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "19691289", "url": "https://glygen.org/publication/PubMed/19691289" }, { "database": "phospho.ELM", "id": "O75449", "url": "http://phospho.elm.eu.org/byAccession/O75449.html" } ], "site_lbl": "Ser170" }, { "start_pos": 42, "end_pos": 42, "kinase_uniprot_canonical_ac": "Q92630-1", "kinase_gene_name": "DYRK2", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O75449", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75449" }, { "database": "PubMed", "id": "19287380", "url": "https://glygen.org/publication/PubMed/19287380" } ], "site_lbl": "Ser42" }, { "start_pos": 42, "end_pos": 42, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by DYRK2", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" }, { "database": "iPTMnet", "id": "O75449", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75449" }, { "database": "PubMed", "id": "19287380", "url": "https://glygen.org/publication/PubMed/19287380" } ], "site_lbl": "Ser42" }, { "start_pos": 441, "end_pos": 441, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O75449", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75449" }, { "database": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" } ], "site_lbl": "Thr441" }, { "start_pos": 81, "end_pos": 81, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O75449", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75449" }, { "database": "PubMed", "id": "32357974", "url": "" } ], "site_lbl": "Thr81" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan", "glycoprotein_reported" ], "publication": [ { "title": "Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin.", "journal": "Journal of cell science", "date": "2000", "authors": "McNally KP, Bazirgan OA, McNally FJ", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" } ], "reference": [ { "type": "PubMed", "id": "10751153", "url": "https://glygen.org/publication/PubMed/10751153" } ] }, { "title": "Katanin inhibition prevents the redistribution of gamma-tubulin at mitosis.", "journal": "Journal of cell science", "date": "2002", "authors": "Buster D, McNally K, McNally FJ", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" } ], "reference": [ { "type": "PubMed", "id": "11870226", "url": "https://glygen.org/publication/PubMed/11870226" } ] }, { "title": "Motif-specific sampling of phosphoproteomes.", "journal": "Journal of proteome research", "date": "2008", "authors": "Ruse CI, McClatchy DB, Lu B, Cociorva D, Motoyama A, Park SK, Yates JR 3rd", "evidence": [ { "database": "iPTMnet", "id": "O75449-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75449-1" } ], "reference": [ { "type": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" } ] }, { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" }, { "database": "iPTMnet", "id": "O75449-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75449-1" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.", "journal": "Analytical chemistry", "date": "2008", "authors": "Wang B, Malik R, Nigg EA, Korner R", "evidence": [ { "database": "iPTMnet", "id": "O75449-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75449-1" } ], "reference": [ { "type": "PubMed", "id": "19007248", "url": "https://glygen.org/publication/PubMed/19007248" } ] }, { "title": "The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Cummings CM, Bentley CA, Perdue SA, Baas PW, Singer JD", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" } ], "reference": [ { "type": "PubMed", "id": "19261606", "url": "https://glygen.org/publication/PubMed/19261606" } ] }, { "title": "Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase.", "journal": "Nature cell biology", "date": "2009", "authors": "Maddika S, Chen J", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" }, { "database": "iPTMnet", "id": "O75449", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75449" } ], "reference": [ { "type": "PubMed", "id": "19287380", "url": "https://glygen.org/publication/PubMed/19287380" } ] }, { "title": "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.", "journal": "Analytical chemistry", "date": "2009", "authors": "Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S", "evidence": [ { "database": "iPTMnet", "id": "O75449-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75449-1" } ], "reference": [ { "type": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" } ] }, { "title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Pan C, Olsen JV, Daub H, Mann M", "evidence": [ { "database": "iPTMnet", "id": "O75449-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75449-1" } ], "reference": [ { "type": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ] }, { "title": "Quantitative analysis of the human spindle phosphoproteome at distinct mitotic stages.", "journal": "Journal of proteome research", "date": "2009", "authors": "Malik R, Lenobel R, Santamaria A, Ries A, Nigg EA, Korner R", "evidence": [ { "database": "iPTMnet", "id": "O75449-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75449-1" } ], "reference": [ { "type": "PubMed", "id": "19691289", "url": "https://glygen.org/publication/PubMed/19691289" } ] }, { "title": "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.", "journal": "Science signaling", "date": "2011", "authors": "Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" }, { "database": "iPTMnet", "id": "O75449", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75449" } ], "reference": [ { "type": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" }, { "database": "iPTMnet", "id": "O75449", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75449" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "N-linked glycosylation enrichment for in-depth cell surface proteomics of diffuse large B-cell lymphoma subtypes.", "journal": "Molecular & cellular proteomics : MCP", "date": "2014", "authors": "Deeb SJ, Cox J, Schmidt-Supprian M, Mann M", "evidence": [ { "database": "GlyGen", "id": "GLY_000143", "url": "https://data.glygen.org/GLY_000143" } ], "reference": [ { "type": "PubMed", "id": "24190977", "url": "https://glygen.org/publication/PubMed/24190977" } ] }, { "title": "Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition.", "journal": "Dev. Cell", "date": "2014", "authors": "Jiang Kai, Hua Shasha, Mohan Renu, Grigoriev Ilya, Yau Kah Wai, Liu Qingyang, Katrukha Eugene A, Altelaar A F Maarten, Heck Albert J R, Hoogenraad Casper C, Akhmanova Anna", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" } ], "reference": [ { "type": "PubMed", "id": "24486153", "url": "https://glygen.org/publication/PubMed/24486153" } ] }, { "title": "Proteomic analysis of the mammalian Katanin family of microtubule-severing enzymes defines Katanin p80 subunit B-like 1 (KATNBL1) as a regulator of mammalian Katanin microtubule-severing.", "journal": "Mol. Cell. Proteomics", "date": "2016", "authors": "Cheung K, Senese S, Kuang J, Bui N, Ongpipattanakul C, Gholkar A, Cohn W, Capri J, Whitelegge JP, Torres JZ", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" } ], "reference": [ { "type": "PubMed", "id": "26929214", "url": "https://glygen.org/publication/PubMed/26929214" } ] }, { "title": "CAMSAP3 accumulates in the pericentrosomal area and accompanies microtubule release from the centrosome via katanin.", "journal": "J. Cell Sci.", "date": "2017", "authors": "Dong C, Xu H, Zhang R, Tanaka N, Takeichi M, Meng W", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" } ], "reference": [ { "type": "PubMed", "id": "28386021", "url": "https://glygen.org/publication/PubMed/28386021" } ] }, { "title": "Elk1 affects katanin and spastin proteins via differential transcriptional and post-transcriptional regulations.", "journal": "PloS one", "date": "2019", "authors": "Kelle D, Kirimtay K, Selcuk E, Karabay A", "evidence": [ { "database": "RefSeq", "id": "NP_001191005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191005" } ], "reference": [ { "type": "PubMed", "id": "30789974", "url": "https://glygen.org/publication/PubMed/30789974" } ] }, { "title": "Katanin P60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer.", "journal": "World journal of surgical oncology", "date": "2020", "authors": "Wang L, Tantai J, Zhu X", "evidence": [ { "database": "RefSeq", "id": "NP_001191005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191005" } ], "reference": [ { "type": "PubMed", "id": "32631334", "url": "https://glygen.org/publication/PubMed/32631334" } ] }, { "title": "Katanin P60 and P80 in papillary thyroid carcinoma patients: Indicators for exacerbated tumor features and worse disease-free survival.", "journal": "Journal of clinical laboratory analysis", "date": "2020", "authors": "Chen Q, Lin F, Lin E, Huang Q, Wu G", "evidence": [ { "database": "RefSeq", "id": "NP_001191005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191005" } ], "reference": [ { "type": "PubMed", "id": "33274499", "url": "https://glygen.org/publication/PubMed/33274499" } ] }, { "title": "A chemical genetics approach to examine the functions of AAA proteins.", "journal": "Nature structural & molecular biology", "date": "2021", "authors": "Cupido T, Jones NH, Grasso MJ, Pisa R, Kapoor TM", "evidence": [ { "database": "RefSeq", "id": "NP_001191005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191005" } ], "reference": [ { "type": "PubMed", "id": "33782614", "url": "https://glygen.org/publication/PubMed/33782614" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "O75449", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75449" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "SUMOylation of microtubule-cleaving enzyme KATNA1 promotes microtubule severing and neurite outgrowth.", "journal": "The Journal of biological chemistry", "date": "2022-09", "authors": "Li Shaojin, Liang Yaozhong, Zou Jianyu, Cai Zhenbin, Yang Hua, Yang Jie, Zhang Yunlong, Lin Hongsheng, Zhang Guowei, Tan Minghui", "evidence": [ { "database": "RefSeq", "id": "NP_001191005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191005" } ], "reference": [ { "type": "PubMed", "id": "35868557", "url": "https://glygen.org/publication/PubMed/35868557" } ] }, { "title": "Design and Preparation of Novel Nitro-Oxide-Grafted Nanospheres with Enhanced Hydrogen Bonding Interaction for O-GlcNAc Analysis.", "journal": "ACS applied materials & interfaces", "date": "2022-10-26", "authors": "Wu Ci, Shi Song, Hou Chunyan, Luo Yang, Byers Stephen, Ma Junfeng", "evidence": [ { "database": "O-GlcNAc Database", "id": "O75449", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75449" } ], "reference": [ { "type": "PubMed", "id": "36240223", "url": "https://glygen.org/publication/PubMed/36240223" } ] }, { "title": "Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs.", "journal": "Mol. Biol. Cell", "date": "1998", "authors": "McNally FJ, Thomas S", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" } ], "reference": [ { "type": "PubMed", "id": "9658175", "url": "https://glygen.org/publication/PubMed/9658175" } ] } ], "pathway": [ { "id": "hsa:11104", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:11104", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q6E0V2-1", "protein_name": "Katanin p60 ATPase-containing subunit A1", "gene_name": "Katna1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031122", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "katanin complex", "id": "GO:0008352", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008352", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" } ], "pmid": "" }, { "name": "spindle pole", "id": "GO:0000922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" } ], "pmid": "" }, { "name": "spindle", "id": "GO:0005819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" } ], "pmid": "" }, { "name": "microtubule cytoskeleton", "id": "GO:0015630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015630", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" } ], "pmid": "" }, { "name": "mitotic spindle pole", "id": "GO:0097431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097431", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 168, "end_pos": 170, "annotation": "n_glycosylation_sequon" }, { "start_pos": 272, "end_pos": 274, "annotation": "n_glycosylation_sequon" }, { "start_pos": 447, "end_pos": 449, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.", "evidence": [ { "database": "UniProtKB", "id": "O75449", "url": "https://www.uniprot.org/uniprot/O75449" }, { "database": "PubMed", "id": "19287380", "url": "https://glygen.org/publication/PubMed/19287380" }, { "database": "PubMed", "id": "19261606", "url": 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