{ "uniprot_canonical_ac": "O75191-1", "uniprot_ac": "O75191", "uniprot_id": "XYLB_HUMAN", "mass": { "chemical_mass": 58382.0, "monoisotopic_mass": 58382.0 }, "refseq": { "ac": "NP_005099", "name": "xylulose kinase isoform 2", "summary": "The protein encoded by this gene shares 22% sequence identity with Hemophilus influenzae xylulokinase, and even higher identity to other gene products in C.elegans (45%) and yeast (31-35%), which are thought to belong to a family of enzymes that include fucokinase, gluconokinase, glycerokinase and xylulokinase. These proteins play important roles in energy metabolism. [provided by RefSeq, Aug 2009].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005099" }, "gene_names": [ { "name": "XYLB", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O75191", "id": "O75191" }, { "name": "XYLB", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005099", "id": "NP_005099" } ], "protein_names": [ { "name": "Xylulose kinase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O75191" }, { "name": "2.7.1.17", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75191" }, { "name": "Xylulokinase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75191" }, { "name": "xylulose kinase isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005099", "id": "NP_005099" }, { "name": "xylulose kinase; xylulokinase homolog (H. influenzae); D-xylulokinase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005099", "id": "NP_005099" } ], "function": [ { "annotation": "Crystals of D-xylulokinase proved to be trigonal, with point-group symmetry 3 and unit-cell parameters a = b = 101.87, c = 158.85 A degrees", "evidence": [ { "database": "RefSeq", "id": "NP_005099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005099" }, { "database": "PubMed", "id": "23027762", "url": "https://glygen.org/publication/PubMed/23027762" } ] }, { "annotation": "Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.", "evidence": [ { "database": "UniProtKB", "id": "O75191", "url": "https://www.uniprot.org/uniprot/O75191#function" }, { "database": "PubMed", "id": "23179721", "url": "https://glygen.org/publication/PubMed/23179721" }, { "database": "UniProtKB", "id": "A0A3B3IRM4", "url": "https://www.uniprot.org/uniprot/A0A3B3IRM4#function" }, { "database": "UniProtKB", "id": "ARBA00003260", "url": "https://www.uniprot.org/uniprot/ARBA00003260#function" }, { "database": "UniProtKB", "id": "RU367058", "url": "https://www.uniprot.org/uniprot/RU367058#function" } ] }, { "annotation": "Single nucleotide polymorphisms in nNOS, renalase, MTHFR, CELSR1 and XYLB genes were found significantly associated with ischemic stroke in Chinese patients.", "evidence": [ { "database": "RefSeq", "id": "NP_005099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005099" }, { "database": "PubMed", "id": "25855559", "url": "https://glygen.org/publication/PubMed/25855559" } ] }, { "annotation": "The protein encoded by this gene shares 22% sequence identity with Hemophilus influenzae xylulokinase, and even higher identity to other gene products in C.elegans (45%) and yeast (31-35%), which are thought to belong to a family of enzymes that include fucokinase, gluconokinase, glycerokinase and xylulokinase. These proteins play important roles in energy metabolism. [provided by RefSeq, Aug 2009].", "evidence": [ { "database": "RefSeq", "id": "NP_005099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005099" } ] }, { "annotation": "Xylulose binds to domain-I and ADP to domain-II, but in an open form of D-xylulokinase they are 10 A apart, implying that a large scale conformational change is required for catalysis.", "evidence": [ { "database": "RefSeq", "id": "NP_005099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005099" }, { "database": "PubMed", "id": "23179721", "url": "https://glygen.org/publication/PubMed/23179721" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "O75191", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O75191" } ], "glycoeffect": [], "start_pos": 85, "end_pos": 85, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "D", "sequence_mut": "E", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "3", "chr_pos": "38362981", "ref_nt": "C", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "D85", "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", 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"" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": 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"description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", 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"http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O75191", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75191" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75191" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O75191", "url": "https://www.uniprot.org/uniprot/O75191" } ], "common_name": "Human" } ], "gene": [ { "name": "XYLB", "url": "https://www.uniprot.org/uniprot/O75191", "locus": { "chromosome": "3", "start_pos": 38421348, "end_pos": 38346760, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000093217", "url": "https://www.ensembl.org/id/ENSG00000093217" } ] } } ], "crossref": [ { "id": "ENSG00000093217", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000093217", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "O75191", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O75191", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "2.7.1.17", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.17&UniProtAcc=O75191", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd07776", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07776", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "XYLB", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=XYLB", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "9942", "url": "https://www.ncbi.nlm.nih.gov/gene/9942", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "12839", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=12839", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "O75191", "url": "https://www.ebi.ac.uk/intact/interactors/id:O75191*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000577", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000577", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018484", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018484", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018485", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018485", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:9942", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:9942", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "604049", "url": "http://www.omim.org/entry/604049", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O75191", "url": "https://www.nextprot.org/entry/NX_O75191", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "NSCALGG", "url": "https://omabrowser.org/oma/group/NSCALGG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "1704034at2759", "url": "http://www.orthodb.org/?query=1704034at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10196", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10196", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10196:SF57", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10196:SF57", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "4BC2", "url": "https://www.rcsb.org/structure/4BC2", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4BC3", "url": "https://www.rcsb.org/structure/4BC3", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4BC4", "url": "https://www.rcsb.org/structure/4BC4", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4BC5", "url": "https://www.rcsb.org/structure/4BC5", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00370", "url": "http://pfam.xfam.org/family/PF00370", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02782", "url": "http://pfam.xfam.org/family/PF02782", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O75191", "url": "https://pharos.nih.gov/targets/O75191", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O75191", "url": "http://purl.obolibrary.org/obo/PR_O75191", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-5661270", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5661270", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_005099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005099", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10964", "url": "https://www.rhea-db.org/rhea/10964", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3B3IRM4", "url": "https://www.uniprot.org/uniprot/A0A3B3IRM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3B3IRM4-1", "url": "https://www.uniprot.org/uniprot/A0A3B3IRM4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3B3IS07", "url": "https://www.uniprot.org/uniprot/A0A3B3IS07", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3B3IS07-1", "url": "https://www.uniprot.org/uniprot/A0A3B3IS07-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9J0N9", "url": "https://www.uniprot.org/uniprot/C9J0N9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9J0N9-1", "url": "https://www.uniprot.org/uniprot/C9J0N9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F8WBF6", "url": "https://www.uniprot.org/uniprot/F8WBF6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F8WBF6-1", "url": "https://www.uniprot.org/uniprot/F8WBF6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75191", "url": "https://www.uniprot.org/uniprot/O75191", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75191-1", "url": "https://www.uniprot.org/uniprot/O75191-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75191-2", "url": "https://www.uniprot.org/uniprot/O75191-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEHAPRRCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSPVLMWVQALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQLQDCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPEAYSHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHLEEKLSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRLEEGDIAVSLGTSDTLFLWLQEPMPALEGHIFCNPVDSQHYMALLCFKNGSLMREKIRNESVSRSWSDFSKALQSTEMGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPGDVEVRALIEGQFMAKRIHAEGLGYRVMSKTKILATGGASHNREILQVLADVFDAPVYVIDTANSACVGSAYRAFHGLAGGTDVPFSEVVKLAPNPRLAATPSPGASQVYEALLPQYAKLEQRILSQTRGPPE", "length": 536, "header": "sp|O75191-1|XYLB_HUMAN Isoform 1 of Xylulose kinase OS=Homo sapiens OX=9606 GN=XYLB PE=1 SV=3 CANONICAL=O75191-1" }, "isoforms": [ { "isoform_ac": "A0A3B3IRM4-1", "url": "", "sequence": { "sequence": "MAEHAPRRCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSPVLMWVQQHGSIYWKAGAQQALTSLSPDLRLHQQLQDCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPEAYSHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHLEEKLSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRLEEGDIAVSLGTSDTLFLWLQEPMPALEGHIFCNPVDSQHYMALLCFKNGSLMREKIRNESVSRSWSDFSKALQSTEMGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPGDVEVRALIEGQFMAKRIHAEGLGYRVMSKTKILATGGASHNREILQVLADVFDAPVYVIDTANSACVGSAYRAFHGLAGGTDVPFSEVVKLAPNPRLAATPSPGASQMESCSVARLECSGTISAHCNLCLLGSSNSPALASRVTGITGTPNHAQLIFVFLVETGFHHVGQDGLNPPTL", "length": 555, "header": "tr|A0A3B3IRM4-1|A0A3B3IRM4_HUMAN Computationally mapped isoform of Xylulose kinase OS=Homo sapiens OX=9606 GN=XYLB PE=1 SV=1 CANONICAL=O75191-1" }, "locus": { "chromosome": "3", "start_pos": 38420054, "end_pos": 38346869, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000650590.1", "url": "https://www.ensembl.org/id/ENST00000650590.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000496840.1", "url": "https://www.ensembl.org/id/ENSP00000496840.1" } ] } }, { "isoform_ac": "A0A3B3IS07-1", "url": "", "sequence": { "sequence": "MAEHAPRRCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSPVLMWVQALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQLQDCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPEAYSHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHLEEKLSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPGHGFKSLPCHLICSNDLFLVQTPHLLP", "length": 309, "header": "tr|A0A3B3IS07-1|A0A3B3IS07_HUMAN Computationally mapped isoform of Xylulokinase OS=Homo sapiens OX=9606 GN=XYLB PE=1 SV=1 CANONICAL=O75191-1" }, "locus": { "chromosome": "3", "start_pos": 38373194, "end_pos": 38346869, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000649234.1", "url": "https://www.ensembl.org/id/ENST00000649234.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000497023.1", "url": "https://www.ensembl.org/id/ENSP00000497023.1" } ] } }, { "isoform_ac": "C9J0N9-1", "url": "", "sequence": { "sequence": "MAEHAPRRCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGATLEAHVEHDRATINLVPE", "length": 66, "header": "tr|C9J0N9-1|C9J0N9_HUMAN Computationally mapped isoform of Xylulokinase OS=Homo sapiens OX=9606 GN=XYLB PE=1 SV=1 CANONICAL=O75191-1" }, "locus": { "chromosome": "3", "start_pos": 38355799, "end_pos": 38346869, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000427323.5", "url": "https://www.ensembl.org/id/ENST00000427323.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000412282.1", "url": "https://www.ensembl.org/id/ENSP00000412282.1" } ] } }, { "isoform_ac": "F8WBF6-1", "url": "", "sequence": { "sequence": "MAEHAPRRCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGNTEVYTGRLEPSRH", "length": 61, "header": "tr|F8WBF6-1|F8WBF6_HUMAN Computationally mapped isoform of Xylulokinase OS=Homo sapiens OX=9606 GN=XYLB PE=1 SV=1 CANONICAL=O75191-1" }, "locus": { "chromosome": "3", "start_pos": 38365241, "end_pos": 38346869, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000424034.5", "url": "https://www.ensembl.org/id/ENST00000424034.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000398845.1", "url": "https://www.ensembl.org/id/ENSP00000398845.1" } ] } }, { "isoform_ac": "O75191-1", "url": "", "sequence": { "sequence": "MAEHAPRRCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSPVLMWVQALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQLQDCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPEAYSHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHLEEKLSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRLEEGDIAVSLGTSDTLFLWLQEPMPALEGHIFCNPVDSQHYMALLCFKNGSLMREKIRNESVSRSWSDFSKALQSTEMGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPGDVEVRALIEGQFMAKRIHAEGLGYRVMSKTKILATGGASHNREILQVLADVFDAPVYVIDTANSACVGSAYRAFHGLAGGTDVPFSEVVKLAPNPRLAATPSPGASQVYEALLPQYAKLEQRILSQTRGPPE", "length": 536, "header": "sp|O75191-1|XYLB_HUMAN Isoform 1 of Xylulose kinase OS=Homo sapiens OX=9606 GN=XYLB PE=1 SV=3 CANONICAL=O75191-1" }, "locus": { "chromosome": "3", "start_pos": 38413010, "end_pos": 38346869, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000207870.8", "url": "https://www.ensembl.org/id/ENST00000207870.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000207870.3", "url": "https://www.ensembl.org/id/ENSP00000207870.3" } ] } }, { "isoform_ac": "O75191-2", "url": "", "sequence": { "sequence": "MDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPEAYSHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHLEEKLSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRLEEGDIAVSLGTSDTLFLWLQEPMPALEGHIFCNPVDSQHYMALLCFKNGSLMREKIRNESVSRSWSDFSKALQSTEMGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPGDVEVRALIEGQFMAKRIHAEGLGYRVMSKTKILATGGASHNREILQVLADVFDAPVYVIDTANSACVGSAYRAFHGLAGGTDVPFSEVVKLAPNPRLAATPSPGASQVYEALLPQYAKLEQRILSQTRGPPE", "length": 399, "header": "sp|O75191-2|XYLB_HUMAN Isoform 2 of Xylulose kinase OS=Homo sapiens OX=9606 GN=XYLB PE=1 SV=3 CANONICAL=O75191-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Nakagawa J, Ishikura S, Asami J, Isaji T, Usami N, Hara A, Sakurai T, Tsuritani K, Oda K, Takahashi M, Yoshimoto M, Otsuka N, Kitamura K", "evidence": [ { "database": "Reactome", "id": "R-HSA-5661270", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5661270" } ], "reference": [ { "type": "PubMed", "id": "11882650", "url": "https://glygen.org/publication/PubMed/11882650" } ] }, { "title": "X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase.", "journal": "Structure (London, England : 1993)", "date": "2003", "authors": "Pauly TA, Ekstrom JL, Beebe DA, Chrunyk B, Cunningham D, Griffor M, Kamath A, Lee SE, Madura R, Mcguire D, Subashi T, Wasilko D, Watts P, Mylari BL, Oates PJ, Adams PD, Rath VL", "evidence": [ { "database": "Reactome", "id": "R-HSA-5661270", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5661270" } ], "reference": [ { "type": "PubMed", "id": "12962626", "url": "https://glygen.org/publication/PubMed/12962626" } ] }, { "title": "Crystal structure of human L-xylulose reductase holoenzyme: probing the role of Asn107 with site-directed mutagenesis.", "journal": "Proteins", "date": "2004", "authors": "El-Kabbani O, Ishikura S, Darmanin C, Carbone V, Chung RP, Usami N, Hara A", "evidence": [ { "database": "Reactome", "id": "R-HSA-5661270", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5661270" } ], "reference": [ { "type": "PubMed", "id": "15103634", "url": "https://glygen.org/publication/PubMed/15103634" } ] }, { "title": "Structural and functional characterization of rabbit and human L-gulonate 3-dehydrogenase.", "journal": "Journal of biochemistry", "date": "2005", "authors": "Ishikura S, Usami N, Araki M, Hara A", "evidence": [ { "database": "Reactome", "id": "R-HSA-5661270", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5661270" } ], "reference": [ { "type": "PubMed", "id": "15809331", "url": "https://glygen.org/publication/PubMed/15809331" } ] }, { "title": "Garrod's fourth inborn error of metabolism solved by the identification of mutations causing pentosuria.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2011", "authors": "Pierce SB, Spurrell CH, Mandell JB, Lee MK, Zeligson S, Bereman MS, Stray SM, Fokstuen S, MacCoss MJ, Levy-Lahad E, King MC, Motulsky AG", "evidence": [ { "database": "Reactome", "id": "R-HSA-5661270", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5661270" } ], "reference": [ { "type": "PubMed", "id": "22042873", "url": "https://glygen.org/publication/PubMed/22042873" } ] }, { "title": "Use of a repetitive seeding protocol to obtain diffraction-quality crystals of a putative human D-xylulokinase.", "journal": "Acta crystallographica. Section F, Structural biology and crystallization communications", "date": "2012", "authors": "Bunker RD, Dickson JM, Caradoc-Davies TT, Loomes KM, Baker EN", "evidence": [ { "database": "RefSeq", "id": "NP_005099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005099" } ], "reference": [ { "type": "PubMed", "id": "23027762", "url": "https://glygen.org/publication/PubMed/23027762" } ] }, { "title": "Structure and function of human xylulokinase, an enzyme with important roles in carbohydrate metabolism.", "journal": "The Journal of biological chemistry", "date": "2013", "authors": "Bunker RD, Bulloch EM, Dickson JM, Loomes KM, Baker EN", "evidence": [ { "database": "UniProtKB", "id": "O75191", "url": "https://www.uniprot.org/uniprot/O75191" }, { "database": "Reactome", "id": "R-HSA-5661270", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5661270" }, { "database": "RefSeq", "id": "NP_005099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005099" } ], "reference": [ { "type": "PubMed", "id": "23179721", "url": "https://glygen.org/publication/PubMed/23179721" } ] }, { "title": "Pooled genetic analysis reveals an association of SNPs of only a few genes with risk predisposition to ischemic stroke in a Chinese population.", "journal": "IUBMB life", "date": "2015", "authors": "Zhang Z, Su G, Guo J, Li J, Wu H, Wang M, Xie X", "evidence": [ { "database": "RefSeq", "id": "NP_005099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005099" } ], "reference": [ { "type": "PubMed", "id": "25855559", "url": "https://glygen.org/publication/PubMed/25855559" } ] }, { "title": "Variability within mammalian sorbitol dehydrogenases. The primary structure of the human liver enzyme.", "journal": "European journal of biochemistry", "date": "1989", "authors": "Karlsson C, Maret W, Auld DS, Hoog JO, Jornvall H", "evidence": [ { "database": "Reactome", "id": "R-HSA-5661270", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5661270" } ], "reference": [ { "type": "PubMed", "id": "2691249", "url": "https://glygen.org/publication/PubMed/2691249" } ] }, { "title": "Purification and characterization of human liver sorbitol dehydrogenase.", "journal": "Biochemistry", "date": "1988", "authors": "Maret W, Auld DS", "evidence": [ { "database": "Reactome", "id": "R-HSA-5661270", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5661270" } ], "reference": [ { "type": "PubMed", "id": "3365415", "url": "https://glygen.org/publication/PubMed/3365415" } ] }, { "title": "The enzymatic defect in essential pentosuria.", "journal": "The New England journal of medicine", "date": "1970", "authors": "Wang YM, Van Eys J", "evidence": [ { "database": "Reactome", "id": "R-HSA-5661270", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5661270" } ], "reference": [ { "type": "PubMed", "id": "4392213", "url": "https://glygen.org/publication/PubMed/4392213" } ] }, { "title": "Mechanism of human aldehyde reductase: characterization of the active site pocket.", "journal": "Biochemistry", "date": "1995", "authors": "Barski OA, Gabbay KH, Grimshaw CE, Bohren KM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5661270", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5661270" } ], "reference": [ { "type": "PubMed", "id": "7669785", "url": "https://glygen.org/publication/PubMed/7669785" } ] }, { "title": "Membrane-bound sorbitol dehydrogenase in human red blood cells. Studies in normal subjects and in enzyme-deficient subjects with congenital cataracts.", "journal": "Journal of inherited metabolic disease", "date": "1993", "authors": "Alvarez A, Martinez A, Ibarra B, Medina C, Bracamontes M, Perea J, Vaca G", "evidence": [ { "database": "Reactome", "id": "R-HSA-5661270", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5661270" } ], "reference": [ { "type": "PubMed", "id": "8487505", "url": "https://glygen.org/publication/PubMed/8487505" } ] }, { "title": "Surface localization of P34H an epididymal protein, during maturation, capacitation, and acrosome reaction of human spermatozoa.", "journal": "Biology of reproduction", "date": "1996", "authors": "Boue F, Blais J, Sullivan R", "evidence": [ { "database": "Reactome", "id": "R-HSA-5661270", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5661270" } ], "reference": [ { "type": "PubMed", "id": "8722620", "url": "https://glygen.org/publication/PubMed/8722620" } ] }, { "title": "Genomic structure of a novel human gene (XYLB) on chromosome 3p22-->p21.3 encoding a xylulokinase-like protein.", "journal": "Cytogenet. Cell Genet.", "date": "1998", "authors": "Tamari M, Daigo Y, Ishikawa S, Nakamura Y", "evidence": [ { "database": "UniProtKB", "id": "O75191", "url": "https://www.uniprot.org/uniprot/O75191" } ], "reference": [ { "type": "PubMed", "id": "9763671", "url": "https://glygen.org/publication/PubMed/9763671" } ] } ], "pathway": [ { "id": "hsa:9942", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:9942", "resource": "KEGG Pathway" }, { "id": "R-HSA-5661270", "name": "Formation of xylulose-5-phosphate", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5661270", "resource": "Reactome", "description": "Formation of xylulose-5-phosphate" } ], "orthologs": [ { "uniprot_canonical_ac": "P42826-1", "protein_name": "Xylulose kinase", "gene_name": "XKS1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MLCSVIQRQTREVSNTMSLDSYYLGFDLSTQQLKCLAINQDLKIVHSETVEFEKDLPHYHTKKGVYIHGDTIECPVAMWLEALDLVLSKYREAKFPLNKVMAVSGSCQQHGSVYWSSQAESLLEQLNKKPEKDLLHYVSSVAFARQTAPNWQDHSTAKQCQEFEECIGGPEKMAQLTGSRAHFRFTGPQILKIAQLEPEAYEKTKTISLVSNFLTSILVGHLVELEEADACGMNLYDIRERKFSDELLHLIDSSSKDKTIRQKLMRAPMKNLIAGTICKYFIEKYGFNTNCKVSPMTGDNLATICSLPLRKNDVLVSLGTSTTVLLVTDKYHPSPNYHLFIHPTLPNHYMGMICYCNGSLARERIRDELNKERENNYEKTNDWTLFNQAVLDDSESSENELGVYFPLGEIVPSVKAINKRVIFNPKTGMIEREVAKFKDKRHDAKNIVESQALSCRVRISPLLSDSNASSQQRLNEDTIVKFDYDESPLRDYLNKRPERTFFVGGASKNDAIVKKFAQVIGATKGNFRLETPNSCALGGCYKAMWSLLYDSNKIAVPFDKFLNDNFPWHVMESISDVDNENWDRYNSKIVPLSELEKTLI", "length": 600 }, "evidence": [ { "id": "O75191", "url": "https://omabrowser.org/oma/group/O75191/", "database": "OMA" } ], "common_name": "Yeast" }, { "uniprot_canonical_ac": "Q3MIF4-1", "protein_name": "Xylulose kinase", "gene_name": "Xylb", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAERAGRRCCLGWDFSTQQVKVVAVDAELNVFYEDSVHFDRDLPEFGTQGGVHVHKDRLTVTSPVLMWVQALDLILEKMKASGFDFSQVLALSGAGQQHGSVYWKTGASLALSSLSPALLLHQQLQACFSVSDCPIWMDSSTTAQCHQLEAAVGGAQALSCLTGSRAYERFTGNQISKIFQKNPEAYSNSERISLVSSFAASLFLGRYSPIDYSDGSGMNLLQIQEKVWSQACLDACAPHLKEKLGSPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRLEEGDVAVSLGTSDTLFLWLQKPMPALEGHIFCNPVDARQYMALLCFKNGSLMREKIRDESASCSWNKFSKALQSTEMGNNGNLGFYFDVMEITPEIIGCHRFNADNMEVSAFPGDVEIRALVEGQFMAKRIHAEGLGYRIMPKTKILATGGASHNKDILQVLADVFGAPVYVIDTTSSACVGSAYRAFHGLAGGTGVAFSEVVKSAPQPSLAATPNPGASQVYAALLPRYAELEQRILSKARGPLE", "length": 536 }, "evidence": [ { "id": "45930706", "url": "http://www.informatics.jax.org/homology/45930706", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3TNA1-1", "protein_name": "Xylulose kinase", "gene_name": "Xylb", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"MGPPKQLKRTFLGFDLSTQKLKAVLLGSSLEVVAAAEVKFDTDLPEFRTTGGANAGSIKNEYFVQPVMWVKAMDIVLDRLVMQQADLSTVAAISGSGQQHGSLYWSKHGINTLQNLDSEKFLHAQIDDSAFVVNRTPIWMDATTTKQCLEMEMAVGGKLNMVELTGSKCYERFTGPQIRKIYQQRCHAYEEANRISLVSSFISSLFLGSVAPIDFSDGSGMNLLDIRKKNWSKECLNVCAPDLDKRLDIPVSPNSILGNVSPYFVERFSFSPDCKVAASTGDNPSALSGMLVGSSWLTISMGTSDTLMMSLKEPLNWEEGHILCHPTETEEFMGLLCFRNASLVREEMNKKTTGGDWDKFNEYLDSTPRGNFGNMAVHFNDMEIIPKAQGILRWNREMDPSSPDAARGVIKFSSPQIEIRALVEGQMLHHRAVAEDLGYKFGPETQILVTGGASVNKSILQTIADVFNAPVHIQDEGFEAALLGAAYRSAYALYLQEAGDGVTPLCYRDYILSLTSNKLSLVCEPHKDSEEIYAPMLQRYREMARVLSNPNT", "length": 552 }, "evidence": [ { "id": "O75191", "url": "https://omabrowser.org/oma/group/O75191/", "database": "OMA" } ], "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "xylulose metabolic process", "id": "GO:0005997", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005997", "evidence": [ { "database": "UniProtKB", "id": "O75191", "url": "https://www.uniprot.org/uniprot/O75191" } ], "pmid": "" }, { "name": "D-xylose metabolic process", "id": "GO:0042732", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042732", "evidence": [ { "database": "UniProtKB", "id": "O75191", "url": "https://www.uniprot.org/uniprot/O75191" } ], "pmid": "" }, { "name": "generation of precursor metabolites and energy", "id": "GO:0006091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006091", "evidence": [ { "database": "UniProtKB", "id": "O75191", "url": "https://www.uniprot.org/uniprot/O75191" } ], "pmid": "" }, { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "O75191", "url": "https://www.uniprot.org/uniprot/O75191" } ], "pmid": "" }, { "name": "phosphorylation", "id": "GO:0016310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016310", "evidence": [ { "database": "UniProtKB", "id": "O75191", "url": "https://www.uniprot.org/uniprot/O75191" } ], "pmid": "" }, { "name": "glucuronate catabolic process to xylulose 5-phosphate", "id": "GO:0019640", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019640", "evidence": [ { "database": "UniProtKB", "id": "O75191", "url": "https://www.uniprot.org/uniprot/O75191" } ], "pmid": "" }, { "name": "xylulose catabolic process", "id": "GO:0005998", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005998", "evidence": [ { "database": "UniProtKB", "id": "O75191", "url": "https://www.uniprot.org/uniprot/O75191" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "O75191", "url": "https://www.uniprot.org/uniprot/O75191" } ], "pmid": "" }, { "name": "xylulokinase activity", "id": "GO:0004856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004856", "evidence": [ { "database": "UniProtKB", "id": "O75191", "url": "https://www.uniprot.org/uniprot/O75191" } ], "pmid": "" }, { "name": "kinase activity", "id": "GO:0016301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016301", "evidence": [ { "database": "UniProtKB", "id": "O75191", "url": "https://www.uniprot.org/uniprot/O75191" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O75191", "url": "https://www.uniprot.org/uniprot/O75191" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 338, "end_pos": 340, "annotation": "n_glycosylation_sequon" }, { "start_pos": 348, "end_pos": 350, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10964", "name": "", "equation": "ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MIF4-1", "O75191-1", "Q3TNA1-1", "P42826-1", "Q9VEQ0-1", "Q9VPT2-1" ], "evidence": [ { "id": "10964", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10964" } ] }, { "id": "R-HSA-5662466", "name": "XYLB phosphorylates D-xylulose", "equation": "", "summary": "Cytosolic xylulose kinase (XYLB) catalyzes the phosphorylation of D-xylulose to form D-xylulose-5-phosphate (XY5P) (Bunker et al. 2013).", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-5661281" ], "output_participant_list": [], "enzyme_list": [ "O75191-1" ], "evidence": [ { "id": "R-HSA-5662466", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5662466" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-5661281", "participant_name": "D-xylulose [cytosol]", "crossref": [ { "id": "17140", "database": "ChEBI", "url": "" }, { "id": "HMDB0001644", "database": 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"url": "" }, { "id": "17140", "database": "ChEBI", "url": "" }, { "id": "HMDB0001644", "database": "HMDB Metabolite", "url": "" }, { "id": "C00310", "database": "COMPOUND", "url": "" }, { "id": "17140", "database": "ChEBI", "url": "" }, { "id": "000100028356", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "O75191", "gene_name": "XYLB", "activity": [ { "ec_number": "2.7.1.17", "activity": "ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+).", "evidence": [ { "id": "O75191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75191" } ] }, { "ec_number": "2.7.1.17", "activity": "", "evidence": [ { "id": "O75191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75191" } ] } ] }, { "uniprot_ac": "P42826", "gene_name": "XKS1", "activity": [ { "ec_number": "2.7.1.17", "activity": "ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+).", "evidence": [ { "id": "P42826", "database": "UniProtKB", "url": 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"cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [ 85 ], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 338, "end_pos": 340 }, { "start_pos": 348, "end_pos": 350 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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