{ "uniprot_canonical_ac": "O75044-1", "uniprot_ac": "O75044", "uniprot_id": "SRGP2_HUMAN", "mass": { "chemical_mass": 120871.0, "monoisotopic_mass": 120871.0 }, "refseq": { "ac": "NP_001164108", "name": "SLIT-ROBO Rho GTPase-activating protein 2 isoform c", "summary": "This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164108" }, "gene_names": [ { "name": "SRGAP2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O75044", "id": "O75044" }, { "name": "ARHGAP34; FNBP2; SRGAP2A; SRGAP3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164108", "id": "NP_001164108" }, { "name": "ARHGAP34", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O75044", "id": "O75044" }, { "name": "FNBP2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O75044", "id": "O75044" }, { "name": "KIAA0456", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O75044", "id": "O75044" }, { "name": "RP11-421E17.2-002", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O75044", "id": "O75044" }, { "name": "SRGAP2A", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O75044", "id": "O75044" }, { "name": "SRGAP2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164108", "id": "NP_001164108" } ], "protein_names": [ { "name": "SLIT-ROBO Rho GTPase-activating protein 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O75044" }, { "name": "Formin-binding protein 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75044" }, { "name": "Rho GTPase-activating protein 34", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75044" }, { "name": "SLIT-ROBO Rho GTPase-activating protein 2 isoform c", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164108", "id": "NP_001164108" }, { "name": "rho GTPase-activating protein 34; formin-binding protein 2; SLIT-ROBO GAP2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164108", "id": "NP_001164108" }, { "name": "srGAP2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75044" } ], "function": [ { "annotation": "FNBP2 gene was linked to IKBKE and NORE1 genes on human chromosome 1q32.1. FNBP2 mRNA was expressed in melanoma, germ cell tumors, chondrosarcoma and retinoblastoma.", "evidence": [ { "database": "RefSeq", "id": "NP_001164108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164108" }, { "database": "PubMed", "id": "12736724", "url": "https://glygen.org/publication/PubMed/12736724" } ] }, { "annotation": "Identification of SRGAP2 as a potential oncogene and a prognostic biomarker in hepatocellular carcinoma.", "evidence": [ { "database": "RefSeq", "id": "NP_001164108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164108" }, { "database": "PubMed", "id": "33984363", "url": "https://glygen.org/publication/PubMed/33984363" } ] }, { "annotation": "Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482).", "evidence": [ { "database": "UniProtKB", "id": "O75044", "url": "https://www.uniprot.org/uniprot/O75044#function" }, { "database": "PubMed", "id": "22559944", "url": "https://glygen.org/publication/PubMed/22559944" }, { "database": "UniProtKB", "id": "Q91Z67", "url": "https://www.uniprot.org/uniprot/Q91Z67#function" }, { "database": "PubMed", "id": "21148482", "url": "https://glygen.org/publication/PubMed/21148482" }, { "database": "PubMed", "id": "20810653", "url": "https://glygen.org/publication/PubMed/20810653" }, { "database": "PubMed", "id": "27373832", "url": "https://glygen.org/publication/PubMed/27373832" }, { "database": "PubMed", "id": "28333212", "url": "https://glygen.org/publication/PubMed/28333212" } ] }, { "annotation": "SRGAP2 controls colorectal cancer chemosensitivity via regulation of mitochondrial complex I activity.", "evidence": [ { "database": "RefSeq", "id": "NP_001164108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164108" }, { "database": "PubMed", "id": "36059022", "url": "https://glygen.org/publication/PubMed/36059022" } ] }, { "annotation": "Stiff matrix induced srGAP2 tension gradients control migration direction in triple-negative breast cancer. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001164108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164108" }, { "database": "PubMed", "id": "36593959", "url": "https://glygen.org/publication/PubMed/36593959" } ] }, { "annotation": "This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014].", "evidence": [ { "database": "RefSeq", "id": "NP_001164108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164108" } ] }, { "annotation": "Tumor-Derived Exosomal miR-29b Reduces Angiogenesis in Pancreatic Cancer by Silencing ROBO1 and SRGAP2. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001164108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164108" }, { "database": "PubMed", "id": "36277474", "url": "https://glygen.org/publication/PubMed/36277474" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs1553380561", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1553380561" }, { "id": "rs1553380561", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1553380561" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 1011, "end_pos": 1011, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SAS->NAS).", "chr_id": "1", "chr_pos": "206461236", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S1011", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs781923753", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs781923753" }, { "id": "rs781923753", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs781923753" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 112, "end_pos": 112, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DHT->NHT).", "chr_id": "1", "chr_pos": "206342919", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D112", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1553335714", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1553335714" }, { "id": "rs1553335714", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1553335714" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 115, "end_pos": 115, "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (TLS->NLS).", "chr_id": "1", "chr_pos": "206342929", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T115", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1553335733", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1553335733" }, { "id": "rs1553335733", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1553335733" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 125, "end_pos": 125, "sequence_org": "I", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NII->NIS).", "chr_id": "1", "chr_pos": "206342959", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I125", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs782371294", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs782371294" }, { "id": "rs782371294", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs782371294" }, { "id": "rs782371294", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs782371294" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 208, "end_pos": 208, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DST->NST).", "chr_id": "1", "chr_pos": "206392824", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D208", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs782125164", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs782125164" }, { "id": "rs782125164", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs782125164" }, { "id": "rs782125164", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs782125164" }, { "id": "rs1553379548", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1553379548" }, { "id": "rs1553379548", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1553379548" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 214, "end_pos": 214, "sequence_org": "R", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NVR->NVS).", "chr_id": "1", "chr_pos": "206392842", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "R214", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs782236953", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs782236953" }, { "id": "rs782236953", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs782236953" }, { "id": "rs782236953", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs782236953#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 408, "end_pos": 408, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DVS->NVS).", "chr_id": "1", "chr_pos": "206406440", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D408", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1553357345", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1553357345" }, { "id": "rs1553357345", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1553357345" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 419, "end_pos": 419, "sequence_org": "M", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NSM->NST).", "chr_id": "1", "chr_pos": "206406474", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "M419", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1301077778", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1301077778" }, { "id": "rs1301077778", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1301077778#frequency_tab" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 425, "end_pos": 425, "sequence_org": "T", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->A).", "chr_id": "1", "chr_pos": "206406491", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T425", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1392282287", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1392282287" }, { "id": "rs1392282287", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1392282287#frequency_tab" }, { "id": "rs1392282287", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1392282287" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 425, "end_pos": 425, "sequence_org": "T", "sequence_mut": "M", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->M).", "chr_id": "1", "chr_pos": "206406492", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T425", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1553373639", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1553373639" }, { "id": "rs1553373639", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1553373639" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 641, "end_pos": 641, "sequence_org": "A", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NLA->NLT).", "chr_id": "1", "chr_pos": "206446121", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A641", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1572209963", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1572209963" }, { "id": "rs1572209963", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1572209963" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 858, "end_pos": 858, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SSS->NSS).", "chr_id": "1", "chr_pos": "206458691", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S858", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1553379478", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1553379478" }, { "id": "rs1553379478", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1553379478" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 904, "end_pos": 904, "sequence_org": "I", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NSI->NST).", "chr_id": "1", "chr_pos": "206458826", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I904", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1572215846", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1572215846" }, { "id": "rs1572215846", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1572215846" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 982, "end_pos": 982, "sequence_org": "T", "sequence_mut": "P", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->P).", "chr_id": "1", "chr_pos": "206461148", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T982", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs782746884", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs782746884" }, { "id": "rs782746884", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs782746884" }, { "id": "rs782746884", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs782746884" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 983, "end_pos": 983, "sequence_org": "S", "sequence_mut": "F", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->F).", "chr_id": "1", "chr_pos": "206461152", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S983", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [ { "start_pos": 108, "end_pos": 108, "sequence_org": "R", "sequence_mut": "K", "comment": "Does not affect protein stability.", "evidence": [ { "database": "UniProtKB", "id": "O75044", "url": "https://www.uniprot.org/uniprot/O75044" }, { "database": "PubMed", "id": "28333212", "url": "https://glygen.org/publication/PubMed/28333212" } ] }, { "start_pos": 108, "end_pos": 108, "sequence_org": "R", "sequence_mut": "L", "comment": "Does not affect protein stability.", "evidence": [ { "database": "UniProtKB", "id": "O75044", "url": "https://www.uniprot.org/uniprot/O75044" }, { "database": "PubMed", "id": "28333212", "url": "https://glygen.org/publication/PubMed/28333212" } ] }, { "start_pos": 108, "end_pos": 108, "sequence_org": "R", "sequence_mut": "S", "comment": "Does not affect protein stability.", "evidence": [ { "database": "UniProtKB", "id": "O75044", "url": "https://www.uniprot.org/uniprot/O75044" }, { "database": "PubMed", "id": "28333212", "url": "https://glygen.org/publication/PubMed/28333212" } ] }, { "start_pos": 108, "end_pos": 108, "sequence_org": "R", "sequence_mut": "W", "comment": "Decreased protein stability.", "evidence": [ { "database": "UniProtKB", "id": "O75044", "url": "https://www.uniprot.org/uniprot/O75044" }, { "database": "PubMed", "id": "28333212", "url": "https://glygen.org/publication/PubMed/28333212" } ] }, { "start_pos": 234, "end_pos": 238, "sequence_org": "KRQAK", "sequence_mut": "EEQAE", "comment": "In F-BARx-R5E mutant; abolished binding to membranes; when associated with 54-E-E-55.", "evidence": [ { "database": "UniProtKB", "id": "O75044", "url": "https://www.uniprot.org/uniprot/O75044" }, { "database": "PubMed", "id": "28333212", "url": "https://glygen.org/publication/PubMed/28333212" } ] }, { "start_pos": 527, "end_pos": 527, "sequence_org": "R", "sequence_mut": "L", "comment": "Abolished RAC1 GTPase activity; when associated with A-566.", "evidence": [ { "database": "UniProtKB", "id": "O75044", "url": "https://www.uniprot.org/uniprot/O75044" }, { "database": "PubMed", "id": "27373832", "url": "https://glygen.org/publication/PubMed/27373832" } ] }, { "start_pos": 54, "end_pos": 55, "sequence_org": "RK", "sequence_mut": "EE", "comment": "In F-BARx-R5E mutant; abolished binding to membranes; when associated 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75044" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { 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"MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAEHHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINKQRKRPESGSIRKTFRSDSHGLSSSLTDSSSPGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGSLNSISRHSSLKNRLDSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIACAFRPVKSVKMAAPVKPPATRPKPTVFPKTNATSPGVNSSTSPQSTDKSCTV", "length": 1071, "header": "sp|O75044-1|SRGP2_HUMAN Isoform 1 of SLIT-ROBO Rho GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=SRGAP2 PE=1 SV=3 CANONICAL=O75044-1" }, "isoforms": [ { "isoform_ac": "A0A075B743-1", "url": "", "sequence": { "sequence": "MKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSKLKEAE", "length": 118, "header": "tr|A0A075B743-1|SRGP2_HUMAN Computationally mapped isoform of SLIT-ROBO Rho GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=SRGAP2 PE=1 SV=1 CANONICAL=O75044-1" }, "locus": { "chromosome": "1", "start_pos": 206392757, "end_pos": 206303307, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000572793.2", "url": "https://www.ensembl.org/id/ENST00000572793.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000459397.2", "url": "https://www.ensembl.org/id/ENSP00000459397.2" } ] } }, { "isoform_ac": "A0A075B7B5-1", "url": "", "sequence": { "sequence": "MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTFLSAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAEHHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTLIS", "length": 789, "header": "tr|A0A075B7B5-1|SRGP2_HUMAN Computationally mapped isoform of SLIT-ROBO Rho GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=SRGAP2 PE=1 SV=1 CANONICAL=O75044-1" }, "locus": { "chromosome": "1", "start_pos": 206454153, "end_pos": 206205971, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000605610.5", "url": "https://www.ensembl.org/id/ENST00000605610.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000473954.1", "url": "https://www.ensembl.org/id/ENSP00000473954.1" } ] } }, { "isoform_ac": "A0A075B7E6-1", "url": "", "sequence": { "sequence": "XLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAEHHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINNFHCGC", "length": 224, "header": "tr|A0A075B7E6-1|A0A075B7E6_HUMAN Computationally mapped isoform of SLIT-ROBO Rho GTPase activating protein 2 OS=Homo sapiens OX=9606 GN=SRGAP2 PE=1 SV=1 CANONICAL=O75044-1" }, "locus": { "chromosome": "1", "start_pos": 206455790, "end_pos": 206440061, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000604925.5", "url": "https://www.ensembl.org/id/ENST00000604925.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000474699.1", "url": "https://www.ensembl.org/id/ENSP00000474699.1" } ] } }, { "isoform_ac": "A0A075B7E9-1", "url": "", "sequence": { "sequence": "ECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINNNLHLDNTKPVTTKQRKRPESGSIRKTFRSDSHGLSSSLTDSSSPGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGSLNSISRHSSLKNRLDSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPA", "length": 294, "header": "tr|A0A075B7E9-1|A0A075B7E9_HUMAN Computationally mapped isoform of SLIT-ROBO Rho GTPase activating protein 2 OS=Homo sapiens OX=9606 GN=SRGAP2 PE=1 SV=1 CANONICAL=O75044-1" }, "locus": { "chromosome": "1", "start_pos": 206461225, "end_pos": 206453199, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000604010.1", "url": "https://www.ensembl.org/id/ENST00000604010.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000474818.1", "url": "https://www.ensembl.org/id/ENSP00000474818.1" } ] } }, { "isoform_ac": "B7ZM87-1", "url": "", "sequence": { "sequence": "MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTFLSAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAEHHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINKQRKRPESGSIRKTFRSDSHGLSSSLTDSSSPGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGSLNSISRHSSLKNRLDSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIACAFRPVKSVKMAAPVKPPATRPKPTVFPKTNATSPGVNSSTSPQSTDKSCTV", "length": 1070, "header": "tr|B7ZM87-1|B7ZM87_HUMAN Computationally mapped isoform of SRGAP2 protein OS=Homo sapiens OX=9606 GN=SRGAP2 PE=1 SV=1 CANONICAL=O75044-1" }, "locus": { "chromosome": "1", "start_pos": 206461417, "end_pos": 206205971, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000624873.3", "url": "https://www.ensembl.org/id/ENST00000624873.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000485517.1", "url": "https://www.ensembl.org/id/ENSP00000485517.1" } ] } }, { "isoform_ac": "E9PDX4-1", "url": "", "sequence": { "sequence": "MKVLNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTFLSAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTVRECYGF", "length": 305, "header": "tr|E9PDX4-1|E9PDX4_HUMAN Computationally mapped isoform of SLIT-ROBO Rho GTPase activating protein 2 OS=Homo sapiens OX=9606 GN=SRGAP2 PE=4 SV=2 CANONICAL=O75044-1" }, "locus": { "chromosome": "1", "start_pos": 206406595, "end_pos": 206384050, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000419187.6", "url": "https://www.ensembl.org/id/ENST00000419187.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000397990.3", "url": "https://www.ensembl.org/id/ENSP00000397990.3" } ] } }, { "isoform_ac": "O75044-1", "url": "", "sequence": { "sequence": "MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAEHHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINKQRKRPESGSIRKTFRSDSHGLSSSLTDSSSPGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGSLNSISRHSSLKNRLDSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIACAFRPVKSVKMAAPVKPPATRPKPTVFPKTNATSPGVNSSTSPQSTDKSCTV", "length": 1071, "header": "sp|O75044-1|SRGP2_HUMAN Isoform 1 of SLIT-ROBO Rho GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=SRGAP2 PE=1 SV=3 CANONICAL=O75044-1" }, "locus": { "chromosome": "1", "start_pos": 206461417, "end_pos": 206205971, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000573034.8", "url": "https://www.ensembl.org/id/ENST00000573034.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000459615.2", "url": "https://www.ensembl.org/id/ENSP00000459615.2" } ] } }, { "isoform_ac": "Q5VZB4-1", "url": "", "sequence": { "sequence": "VKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAEHHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINK", "length": 450, "header": "tr|Q5VZB4-1|SRGP2_HUMAN Computationally mapped isoform of SLIT-ROBO Rho GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=SRGAP2 PE=1 SV=1 CANONICAL=O75044-1" }, "locus": { "chromosome": "1", "start_pos": 206455025, "end_pos": 206406377, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000605476.5", "url": "https://www.ensembl.org/id/ENST00000605476.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000474270.1", "url": "https://www.ensembl.org/id/ENSP00000474270.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 424, "start_aa": "Ser", "end_pos": 424, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser424", "evidence": [ { "id": "O75044", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O75044" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 425, "start_aa": "Thr", "end_pos": 425, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr425", "evidence": [ { "id": "O75044", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O75044" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 982, "start_aa": "Thr", "end_pos": 982, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr982", "evidence": [ { "id": "O75044", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75044" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 983, "start_aa": "Ser", "end_pos": 983, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser983", "evidence": [ { "id": "O75044", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75044" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 990, "start_aa": "Ser", "end_pos": 990, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser990", "evidence": [ { "id": "O75044", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75044" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "O75044", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O75044" }, { "id": "32938750", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32938750" } ] } ], "phosphorylation": [ { "start_pos": 1011, "end_pos": 1011, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": 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Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-alpha.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Hammond SM, Jenco JM, Nakashima S, Cadwallader K, Gu Q, Cook S, Nozawa Y, Prestwich GD, Frohman MA, Morris AJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013149", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013149" } ], "reference": [ { "type": "PubMed", "id": "9013646", "url": "https://glygen.org/publication/PubMed/9013646" } ] }, { "title": "Tyrosine phosphorylation of the vav proto-oncogene product links FcepsilonRI to the Rac1-JNK pathway.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Teramoto H, Salem P, Robbins KC, Bustelo XR, Gutkind JS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013149", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013149" } ], "reference": [ { "type": "PubMed", "id": "9099726", "url": "https://glygen.org/publication/PubMed/9099726" } ] }, { "title": "RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1997", "authors": "Adra CN, Manor D, Ko JL, Zhu S, Horiuchi T, Van Aelst L, Cerione RA, Lim B", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013148", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013148" } ], "reference": [ { "type": "PubMed", "id": "9113980", "url": "https://glygen.org/publication/PubMed/9113980" } ] }, { "title": "Characterization of RAC3, a novel member of the Rho family.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Haataja L, Groffen J, Heisterkamp N", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013423", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013423" } ], "reference": [ { "type": "PubMed", "id": "9252344", "url": "https://glygen.org/publication/PubMed/9252344" } ] }, { "title": "Characterization of the interactions between the small GTPase Cdc42 and its GTPase-activating proteins and putative effectors. Comparison of kinetic properties of Cdc42 binding to the Cdc42-interactive domains.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Zhang B, Wang ZX, Zheng Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013148", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013148" } ], "reference": [ { "type": "PubMed", "id": "9268338", "url": "https://glygen.org/publication/PubMed/9268338" } ] }, { "title": "A novel GTPase-activating protein for Rho interacts with a PDZ domain of the protein-tyrosine phosphatase PTPL1.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Saras J, Franzen P, Aspenstrom P, Hellman U, Gonez LJ, Heldin CH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013149", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013149" } ], "reference": [ { "type": "PubMed", "id": "9305890", "url": "https://glygen.org/publication/PubMed/9305890" } ] }, { "title": "WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1997", "authors": "Ramesh N, Anton IM, Hartwig JH, Geha RS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013148", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013148" } ], "reference": [ { "type": "PubMed", "id": "9405671", "url": "https://glygen.org/publication/PubMed/9405671" } ] }, { "title": "Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.", "journal": "Science (New York, N.Y.)", "date": "1998", "authors": "Nimnual AS, Yatsula BA, Bar-Sagi D", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013149", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013149" } ], "reference": [ { "type": "PubMed", "id": "9438849", "url": "https://glygen.org/publication/PubMed/9438849" } ] }, { "title": "Human myosin-IXb is a mechanochemically active motor and a GAP for rho.", "journal": "Journal of cell science", "date": "1998", "authors": "Post PL, Bokoch GM, Mooseker MS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013149", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013149" } ], "reference": [ { "type": "PubMed", "id": "9490638", "url": "https://glygen.org/publication/PubMed/9490638" } ] }, { "title": "MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cells.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Toure A, Dorseuil O, Morin L, Timmons P, Jegou B, Reibel L, Gacon G", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013149", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013149" } ], "reference": [ { "type": "PubMed", "id": "9497316", "url": "https://glygen.org/publication/PubMed/9497316" } ] }, { "title": "Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation.", "journal": "Nature", "date": "1998", "authors": "Billuart P, Bienvenu T, Ronce N, des Portes V, Vinet MC, Zemni R, Roest Crollius H, Carrie A, Fauchereau F, Cherry M, Briault S, Hamel B, Fryns JP, Beldjord C, Kahn A, Moraine C, Chelly J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013149", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013149" } ], "reference": [ { "type": "PubMed", "id": "9582072", "url": "https://glygen.org/publication/PubMed/9582072" } ] }, { "title": "The role of profilin in actin polymerization and nucleotide exchange.", "journal": "Biochemistry", "date": "1998", "authors": "Korenbaum E, Nordberg P, Bjorkegren-Sjogren C, Schutt CE, Lindberg U, Karlsson R", "evidence": [ { "database": "Reactome", "id": "R-HSA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5663220" } ], "reference": [ { "type": "PubMed", "id": "9649308", "url": "https://glygen.org/publication/PubMed/9649308" } ] 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