{ "uniprot_canonical_ac": "O60488-1", "uniprot_ac": "O60488", "uniprot_id": "ACSL4_HUMAN", "mass": { "chemical_mass": 79188.0, "monoisotopic_mass": 79188.0 }, "refseq": { "ac": "NP_001305438", "name": "long-chain-fatty-acid--CoA ligase 4 isoform 2", "summary": "The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the cognitive disability or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jan 2016].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305438" }, "gene_names": [ { "name": "ACSL4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O60488", "id": "O60488" }, { "name": "ACS4; FACL4; LACS4; MRX63; MRX68; XLID63", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305438", "id": "NP_001305438" }, { "name": "ACS4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O60488", "id": "O60488" }, { "name": "ACSL4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305438", "id": "NP_001305438" }, { "name": "FACL4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O60488", "id": "O60488" }, { "name": "LACS4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O60488", "id": "O60488" } ], "protein_names": [ { "name": "Long-chain-fatty-acid--CoA ligase 4", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O60488" }, { "name": "6.2.1.15", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60488" }, { "name": "6.2.1.3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60488" }, { "name": "Arachidonate--CoA ligase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60488" }, { "name": "LACS 4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60488" }, { "name": "Long-chain acyl-CoA synthetase 4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60488" }, { "name": "fatty-acid-Coenzyme A ligase, long-chain 4; lignoceroyl-CoA synthase; long-chain-fatty-acid--CoA ligase 4; acyl-CoA synthetase 4; long-chain acyl-CoA synthetase 4; long-chain fatty-acid-Coenzyme A ligase 4; arachidonate--CoA ligase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305438", "id": "NP_001305438" }, { "name": "long-chain-fatty-acid--CoA ligase 4 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305438", "id": "NP_001305438" } ], "function": [ { "annotation": "Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:24269233, PubMed:22633490, PubMed:21242590). Preferentially activates arachidonate and eicosapentaenoate as substrates (PubMed:21242590). Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (PubMed:21242590).", "evidence": [ { "database": "UniProtKB", "id": "O60488", "url": "https://www.uniprot.org/uniprot/O60488#function" }, { "database": "PubMed", "id": "22633490", "url": "https://glygen.org/publication/PubMed/22633490" }, { "database": "UniProtKB", "id": "O35547", "url": "https://www.uniprot.org/uniprot/O35547#function" }, { "database": "PubMed", "id": "24269233", "url": "https://glygen.org/publication/PubMed/24269233" }, { "database": "PubMed", "id": "21242590", "url": "https://glygen.org/publication/PubMed/21242590" } ] }, { "annotation": "FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation", "evidence": [ { "database": "RefSeq", "id": "NP_001305438", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305438" }, { "database": "PubMed", "id": "11889465", "url": "https://glygen.org/publication/PubMed/11889465" } ] }, { "annotation": "Methylation Regulation of LPCAT3 Improves Osteoarthritis by Regulating ACSL4 to Inhibit Chondrocyte Ferroptosis.", "evidence": [ { "database": "RefSeq", "id": "NP_001305438", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305438" }, { "database": "PubMed", "id": "38073444", "url": "https://glygen.org/publication/PubMed/38073444" } ] }, { "annotation": "MiRNA-211 maintains metabolic homeostasis in medulloblastoma through its target gene long-chain acyl-CoA synthetase 4. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001305438", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305438" }, { "database": "PubMed", "id": "38115140", "url": "https://glygen.org/publication/PubMed/38115140" } ] }, { "annotation": "RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4.", "evidence": [ { "database": "RefSeq", "id": "NP_001305438", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305438" }, { "database": "PubMed", "id": "38040804", "url": "https://glygen.org/publication/PubMed/38040804" } ] }, { "annotation": "SENP1 inhibits ferroptosis and promotes head and neck squamous cell carcinoma by regulating ACSL4 protein stability via SUMO1.", "evidence": [ { "database": "RefSeq", "id": "NP_001305438", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305438" }, { "database": "PubMed", "id": "38186303", "url": "https://glygen.org/publication/PubMed/38186303" } ] }, { "annotation": "The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the cognitive disability or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jan 2016].", "evidence": [ { "database": "RefSeq", "id": "NP_001305438", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305438" } ] } ], "disease": [ { "disease_id": "DOID:0111860", "recommended_name": { "id": "DOID:0111860", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111860", "name": "AMME complex", "description": "A syndrome characterized by Alport syndrome, mental retardation, midface hypoplasia, and elliptocytosis that has_material_basis_in hemizygous deletion of multiple genes including COL4A5, FACL4 and AMMECR1 on chromosome Xq22.3." }, "synonyms": [ { "id": "DOID:0111860", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111860", "name": "ATS-MR", "description": "" }, { "id": "DOID:0111860", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111860", "name": "Alport syndrome-intellectual disability-midface hypoplasia-elliptocytosis syndrome", "description": "" }, { "id": "DOID:0111860", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111860", "name": "AMME syndrome", "description": "" }, { "id": "DOID:0111860", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111860", "name": "chromosome Xq22.3 telomeric deletion syndrome", "description": "" }, { "id": "MONDO:0010263", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010263", "name": "Alport syndrome-intellectual disability-midface hypoplasia-elliptocytosis syndrome", "description": "" }, { "id": "MONDO:0010263", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010263", "name": "AMME complex", "description": "" }, { "id": "MONDO:0010263", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010263", "name": "AMME syndrome", "description": "" }, { "id": "MONDO:0010263", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010263", "name": "ATS-MR", "description": "" }, { "id": "MONDO:0010263", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010263", "name": "Alport syndrome, intellectual disability, midface hypoplasia, and elliptocytosis", "description": "" }, { "id": "MONDO:0010263", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010263", "name": "Alport syndrome, mental retardation, midface hypoplasia, and elliptocytosis", "description": "" }, { "id": "MONDO:0010263", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010263", "name": "Ats-Mr", "description": "" }, { "id": "MONDO:0010263", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010263", "name": "chromosome Xq22.3 telomeric deletion syndrome", "description": "" }, { "id": "MIM:300194", "resource": "MIM", "url": "https://www.omim.org/entry/300194", "name": "AMME complex", "description": "AMME complex" } ], "evidence": [ { "id": "300194", "database": "MIM", "url": "https://www.omim.org/entry/300194" } ] }, { "disease_id": "DOID:0112050", "recommended_name": { "id": "DOID:0112050", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112050", "name": "non-syndromic X-linked intellectual disability 63", "description": "A non-syndromic X-linked intellectual disability characterized by moderate to severe nonprogressive intellectual disability in males and moderate intellectual disability to normal intelligence in females that has_material_basis_in heterozygous mutation in the ACSL4 gene on chromosome Xq23." }, "synonyms": [ { "id": "DOID:0112050", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112050", "name": "MRX63", "description": "" }, { "id": "DOID:0112050", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112050", "name": "MRX68", "description": "" }, { "id": "DOID:0112050", "resource": "Disease Ontology", "url": 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"MKLKLNVLTIILLPVHLLITIYSALIFIPWYFLTNAKKKNAMAKRIKAKPTSDKPGSPYRSVTHFDSLAVIDIPGADTLDKLFDHAVSKFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYKWMNYLEVNRRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGKEAVVHGLNESEASYLITSVELLESKLKTALLDISCVKHIIYVDNKAINKAEYPEGFEIHSMQSVEELGSNPENLGIPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPKDTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLEQIKKGYDAPLCNLLLFKKVKALLGGNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYTINDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKSDQSYVISFVVPNQKRLTLLAQQKGVEGTWVDICNNPAMEAEILKEIREAANAMKLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELRNHYLKDIERMYGGK", "length": 711, "header": "sp|O60488-1|ACSL4_HUMAN Isoform 1 of Long-chain-fatty-acid--CoA ligase 4 OS=Homo sapiens OX=9606 GN=ACSL4 PE=1 SV=2 CANONICAL=O60488-1" }, "isoforms": [ { "isoform_ac": "A0A804HI36-1", "url": "", "sequence": { "sequence": "MKLKLNVLTIILLPVHLLITIYSALIFIPWYFLTNAKKKNAMAKRIKAKPTSDKPGSPYRSVTHFDSLAVIDIPGADTLDKLFDHAVSKFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYKWMNYLEVNRRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGKEAVVHGLNESEASYLITSVELLESKLKTALLDISCVKHIIYVDNKAINKAEYPEGFEIHSMQSVEELGSNPENLGIPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPKDTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPVKALLGGNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYTINDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKSDQSYVISFVVPNQKRLTLLAQQKGVEGTWVDICNNPAMEAEILKEIREAANAMKLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELRNHYLKDIERMYGGK", "length": 659, "header": "tr|A0A804HI36-1|ACSL4_HUMAN Computationally mapped isoform of Long-chain-fatty-acid--CoA ligase 4 OS=Homo sapiens OX=9606 GN=ACSL4 PE=1 SV=1 CANONICAL=O60488-1" }, "locus": { "chromosome": "X", "start_pos": 109683486, "end_pos": 109644032, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000682031.1", "url": "https://www.ensembl.org/id/ENST00000682031.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000506881.1", "url": "https://www.ensembl.org/id/ENSP00000506881.1" } ] } }, { "isoform_ac": "D6RDA8-1", "url": "", "sequence": { "sequence": "MKLKLNVLTIILLPVHLLITIYSALIFIPWYFLTNAKKKNAMAKRIKAKPTSDKPGSPYRSVTHFDSLAVIDIPGADTLDKLFDHAVSKFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYKWMNY", "length": 128, "header": "tr|D6RDA8-1|D6RDA8_HUMAN Computationally mapped isoform of Acyl-CoA synthetase long chain family member 4 OS=Homo sapiens OX=9606 GN=ACSL4 PE=1 SV=1 CANONICAL=O60488-1" }, "locus": { "chromosome": "X", "start_pos": 109683486, "end_pos": 109682864, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000508092.5", "url": "https://www.ensembl.org/id/ENST00000508092.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000425378.1", "url": "https://www.ensembl.org/id/ENSP00000425378.1" } ] } }, { "isoform_ac": "D6RF95-1", "url": "", "sequence": { "sequence": "MAKRIKAKPTSDKPGSPYRSVTHFDSLAVIDIPGADTLDKLFDHAVSKFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYKWMNYLEVNRRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGKEAVVHGLNE", "length": 154, "header": "tr|D6RF95-1|D6RF95_HUMAN Computationally mapped isoform of long-chain-fatty-acid--CoA ligase OS=Homo sapiens OX=9606 GN=ACSL4 PE=1 SV=1 CANONICAL=O60488-1" }, "locus": { "chromosome": "X", "start_pos": 109683363, "end_pos": 109681320, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000505855.1", "url": "https://www.ensembl.org/id/ENST00000505855.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000424808.1", "url": "https://www.ensembl.org/id/ENSP00000424808.1" } ] } }, { "isoform_ac": "H0Y9A0-1", "url": "", "sequence": { "sequence": "XTLFKIGYDYKLEQIKKGYDAPLCNLLLFKKVKALLGGNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYTINDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYSVDENGQRNLG", "length": 156, "header": "tr|H0Y9A0-1|H0Y9A0_HUMAN Computationally mapped isoform of long-chain-fatty-acid--CoA ligase OS=Homo sapiens OX=9606 GN=ACSL4 PE=1 SV=1 CANONICAL=O60488-1" }, "locus": { "chromosome": "X", "start_pos": 109669109, "end_pos": 109659421, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000514500.1", "url": "https://www.ensembl.org/id/ENST00000514500.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000423539.1", "url": "https://www.ensembl.org/id/ENSP00000423539.1" } ] } }, { "isoform_ac": "O60488-1", "url": "", "sequence": { "sequence": "MKLKLNVLTIILLPVHLLITIYSALIFIPWYFLTNAKKKNAMAKRIKAKPTSDKPGSPYRSVTHFDSLAVIDIPGADTLDKLFDHAVSKFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYKWMNYLEVNRRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGKEAVVHGLNESEASYLITSVELLESKLKTALLDISCVKHIIYVDNKAINKAEYPEGFEIHSMQSVEELGSNPENLGIPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPKDTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLEQIKKGYDAPLCNLLLFKKVKALLGGNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYTINDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKSDQSYVISFVVPNQKRLTLLAQQKGVEGTWVDICNNPAMEAEILKEIREAANAMKLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELRNHYLKDIERMYGGK", "length": 711, "header": "sp|O60488-1|ACSL4_HUMAN Isoform 1 of Long-chain-fatty-acid--CoA ligase 4 OS=Homo sapiens OX=9606 GN=ACSL4 PE=1 SV=2 CANONICAL=O60488-1" }, "locus": { "chromosome": "X", "start_pos": 109683486, "end_pos": 109644032, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000469796.7", "url": "https://www.ensembl.org/id/ENST00000469796.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000419171.2", "url": "https://www.ensembl.org/id/ENSP00000419171.2" } ] } }, { "isoform_ac": "O60488-2", "url": "", "sequence": { "sequence": "MAKRIKAKPTSDKPGSPYRSVTHFDSLAVIDIPGADTLDKLFDHAVSKFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYKWMNYLEVNRRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGKEAVVHGLNESEASYLITSVELLESKLKTALLDISCVKHIIYVDNKAINKAEYPEGFEIHSMQSVEELGSNPENLGIPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPKDTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLEQIKKGYDAPLCNLLLFKKVKALLGGNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYTINDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKSDQSYVISFVVPNQKRLTLLAQQKGVEGTWVDICNNPAMEAEILKEIREAANAMKLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELRNHYLKDIERMYGGK", "length": 670, "header": "sp|O60488-2|ACSL4_HUMAN Isoform 2 of Long-chain-fatty-acid--CoA ligase 4 OS=Homo sapiens OX=9606 GN=ACSL4 PE=1 SV=2 CANONICAL=O60488-1" }, "locus": { "chromosome": "X", "start_pos": 109683363, "end_pos": 109644032, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000672401.1", "url": "https://www.ensembl.org/id/ENST00000672401.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000500273.1", "url": "https://www.ensembl.org/id/ENSP00000500273.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 51, "start_aa": "Thr", "end_pos": 51, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr51", "evidence": [ { "id": "O60488", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60488" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "32357142", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32357142" }, { "id": "33465208", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33465208" }, { "id": "O60488", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O60488" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 52, "start_aa": "Ser", "end_pos": 52, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser52", "evidence": [ { "id": "O60488", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O60488" }, { "id": "33465208", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33465208" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 57, "start_aa": "Ser", "end_pos": 57, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser57", "evidence": [ { "id": "O60488", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O60488" }, { "id": "33465208", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33465208" } ] } ], "phosphorylation": [ { "start_pos": 140, "end_pos": 140, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O60488", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60488" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser140" }, { "start_pos": 447, "end_pos": 447, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O60488", "url": "https://www.uniprot.org/uniprot/O60488" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O60488", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60488" } ], "site_lbl": "Ser447" }, { "start_pos": 674, "end_pos": 674, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O60488", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60488" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "phospho.ELM", "id": "O60488", "url": "http://phospho.elm.eu.org/byAccession/O60488.html" } ], "site_lbl": "Ser674" }, { "start_pos": 679, "end_pos": 679, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O60488", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60488" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "phospho.ELM", "id": "O60488", "url": "http://phospho.elm.eu.org/byAccession/O60488.html" } ], "site_lbl": "Thr679" }, { "start_pos": 95, "end_pos": 95, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O60488", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60488" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser95" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors.", "journal": "The Biochemical journal", "date": "1999", "authors": "Malhotra KT, Malhotra K, Lubin BH, Kuypers FA", "evidence": [ { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "10548543", "url": "https://glygen.org/publication/PubMed/10548543" } ] }, { "title": "Very long-chain acyl-CoA synthetases. Human `bubblegum` represents a new family of proteins capable of activating very long-chain fatty acids.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Steinberg SJ, Morgenthaler J, Heinzer AK, Smith KD, Watkins PA", "evidence": [ { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "10954726", "url": "https://glygen.org/publication/PubMed/10954726" } ] }, { "title": "FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation.", "journal": "Nature genetics", "date": "2002", "authors": "Meloni I, Muscettola M, Raynaud M, Longo I, Bruttini M, Moizard MP, Gomot M, Chelly J, des Portes V, Fryns JP, Ropers HH, Magi B, Bellan C, Volpi N, Yntema HG, Lewis SE, Schaffer JE, Renieri A", "evidence": [ { "database": "UniProtKB", "id": "O60488", "url": "https://www.uniprot.org/uniprot/O60488" }, { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" }, { "database": "RefSeq", "id": "NP_001305438", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305438" } ], "reference": [ { "type": "PubMed", "id": "11889465", "url": "https://glygen.org/publication/PubMed/11889465" } ] }, { "title": "Identification and expression of mammalian long-chain PUFA elongation enzymes.", "journal": "Lipids", "date": "2002", "authors": "Leonard AE, Kelder B, Bobik EG, Chuang LT, Lewis CJ, Kopchick JJ, Mukerji P, Huang YS", "evidence": [ { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "12371743", "url": "https://glygen.org/publication/PubMed/12371743" } ] }, { "title": "Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Moon YA, Horton JD", "evidence": [ { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "12482854", "url": "https://glygen.org/publication/PubMed/12482854" } ] }, { "title": "A third MRX family (MRX68) is the result of mutation in the long chain fatty acid-CoA ligase 4 (FACL4) gene: proposal of a rapid enzymatic assay for screening mentally retarded patients.", "journal": "Journal of medical genetics", "date": "2003", "authors": "Longo I, Frints SG, Fryns JP, Meloni I, Pescucci C, Ariani F, Borghgraef M, Raynaud M, Marynen P, Schwartz C, Renieri A, Froyen G", "evidence": [ { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "12525535", "url": "https://glygen.org/publication/PubMed/12525535" } ] }, { "title": "The acyl-CoA synthetase `bubblegum` (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation..", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Pei Z, Oey NA, Zuidervaart MM, Jia Z, Li Y, Steinberg SJ, Smith KD, Watkins PA", "evidence": [ { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "12975357", "url": "https://glygen.org/publication/PubMed/12975357" } ] }, { "title": "Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Pei Z, Fraisl P, Berger J, Jia Z, Forss-Petter S, Watkins PA", "evidence": [ { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "15469937", "url": "https://glygen.org/publication/PubMed/15469937" } ] }, { "title": "Fatty acid translocase (FAT/CD36) is localized on insulin-containing granules in human pancreatic beta-cells and mediates fatty acid effects on insulin secretion.", "journal": "Diabetes", "date": "2005", "authors": "Noushmehr H, D'Amico E, Farilla L, Hui H, Wawrowsky KA, Mlynarski W, Doria A, Abumrad NA, Perfetti R", "evidence": [ { "database": "Reactome", "id": "R-HSA-434313", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-434313" } ], "reference": [ { "type": "PubMed", "id": "15677505", "url": "https://glygen.org/publication/PubMed/15677505" } ] }, { "title": "Dominant negative mechanism underlies autosomal dominant Stargardt-like macular dystrophy linked to mutations in ELOVL4.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Grayson C, Molday RS", "evidence": [ { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "16036915", "url": "https://glygen.org/publication/PubMed/16036915" } ] }, { "title": "The second member of the human and murine bubblegum family is a testis- and brainstem-specific acyl-CoA synthetase.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Pei Z, Jia Z, Watkins PA", "evidence": [ { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "16371355", "url": "https://glygen.org/publication/PubMed/16371355" } ] }, { "title": "The consensus coding sequences of human breast and colorectal cancers.", "journal": "Science (New York, N.Y.)", "date": "2006", "authors": "Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu 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"https://www.ebi.ac.uk/QuickGO/term/GO:0008610", "evidence": [ { "database": "UniProtKB", "id": "O60488", "url": "https://www.uniprot.org/uniprot/O60488" } ], "pmid": "" }, { "name": "positive regulation of cell growth", "id": "GO:0030307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030307", "evidence": [ { "database": "UniProtKB", "id": "O60488", "url": "https://www.uniprot.org/uniprot/O60488" } ], "pmid": "" }, { "name": "positive regulation of insulin secretion", "id": "GO:0032024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032024", "evidence": [ { "database": "UniProtKB", "id": "O60488", "url": "https://www.uniprot.org/uniprot/O60488" } ], "pmid": "" }, { "name": "long-chain fatty-acyl-CoA biosynthetic process", "id": "GO:0035338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035338", "evidence": [ { "database": "UniProtKB", "id": "O60488", "url": "https://www.uniprot.org/uniprot/O60488" } ], "pmid": "" }, { "name": "negative regulation of prostaglandin secretion", "id": "GO:0032307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032307", "evidence": [ { "database": "UniProtKB", "id": "O60488", "url": "https://www.uniprot.org/uniprot/O60488" } ], "pmid": "" }, { "name": "embryonic process involved in female pregnancy", "id": "GO:0060136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060136", "evidence": [ { "database": "UniProtKB", "id": "O60488", "url": "https://www.uniprot.org/uniprot/O60488" } ], "pmid": "" }, { "name": "neuron differentiation", "id": "GO:0030182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030182", "evidence": [ { "database": "UniProtKB", "id": "O60488", "url": "https://www.uniprot.org/uniprot/O60488" } ], "pmid": "" }, { "name": "long-chain fatty-acyl-CoA metabolic process", "id": "GO:0035336", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035336", "evidence": [ { "database": "UniProtKB", "id": "O60488", "url": "https://www.uniprot.org/uniprot/O60488" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "O60488", "url": "https://www.uniprot.org/uniprot/O60488" } ], "pmid": "" }, { "name": "long-chain fatty acid-CoA ligase activity", "id": "GO:0004467", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004467", "evidence": [ { "database": "UniProtKB", "id": "O60488", "url": "https://www.uniprot.org/uniprot/O60488" } ], "pmid": "" }, { "name": "very long-chain fatty acid-CoA ligase activity", "id": "GO:0031957", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031957", "evidence": [ { "database": "UniProtKB", "id": "O60488", "url": "https://www.uniprot.org/uniprot/O60488" } ], "pmid": "" }, { "name": "arachidonate-CoA ligase activity", "id": "GO:0047676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047676", "evidence": [ { "database": "UniProtKB", "id": "O60488", "url": "https://www.uniprot.org/uniprot/O60488" } ], "pmid": "" }, { "name": "palmitoyl-CoA ligase activity", "id": "GO:0090433", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090433", "evidence": [ { "database": "UniProtKB", "id": "O60488", "url": "https://www.uniprot.org/uniprot/O60488" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 10, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O60488", "url": "https://www.uniprot.org/uniprot/O60488" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "O60488", "url": "https://www.uniprot.org/uniprot/O60488" } ], "pmid": "" }, { "name": "peroxisomal membrane", "id": "GO:0005778", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005778", "evidence": [ { "database": "UniProtKB", "id": "O60488", "url": "https://www.uniprot.org/uniprot/O60488" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "O60488", "url": "https://www.uniprot.org/uniprot/O60488" } ], "pmid": "" }, { "name": "lipid droplet", "id": "GO:0005811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005811", "evidence": [ { "database": "UniProtKB", "id": "O60488", "url": "https://www.uniprot.org/uniprot/O60488" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "O60488", "url": "https://www.uniprot.org/uniprot/O60488" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "O60488", "url": "https://www.uniprot.org/uniprot/O60488" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "O60488", "url": "https://www.uniprot.org/uniprot/O60488" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "O60488", "url": "https://www.uniprot.org/uniprot/O60488" } ], "pmid": "" }, { "name": "mitochondria-associated endoplasmic reticulum membrane", "id": "GO:0044233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044233", "evidence": [ { "database": "UniProtKB", "id": "O60488", "url": "https://www.uniprot.org/uniprot/O60488" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 194, "end_pos": 196, "annotation": "n_glycosylation_sequon" }, { "start_pos": 525, "end_pos": 527, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "15421", "name": "", "equation": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35547-1", "O88813-1", "A1L1K7-1", "Q63151-1", "P18163-1", "P33124-1", "Q924N5-1", "P97524-1", "P97849-1", "Q9ES38-1", "Q9UKU0-4", "O95573-1", "P33121-1", "O60488-1", "Q96GR2-1", "Q5FVE4-1", "Q9ULC5-1", "O14975-1", "Q6PCB7-1", "Q6P1M0-1", "Q9Y2P5-1", "Q9Y2P4-1", "Q5K4L6-1", "Q91WC3-1", "Q8JZR0-1", "P41216-1", "Q2XU92-1", "Q99PU5-1", "Q9CZW4-1", "Q9QUJ7-1", "O35488-1", "Q60714-1", "Q91VE0-1", "E9Q9W4-1", "O88561-1", "Q4LDG0-1", "P30624-1", "P39002-1", "P39518-1", "P47912-1", "Q1ZXQ4-1", "Q55DR6-1", "Q9VVT8-1", "Q9V3U0-1", "Q9V3S9-1", "A0A0B4KFE4-1" ], "evidence": [ { "id": "15421", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15421" } ] }, { "id": "19713", "name": "", "equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35547-1", "O88813-1", "A1L1K7-1", "Q63151-1", "P18163-1", "P33124-1", "P97524-1", "P97849-1", "Q9UKU0-4", "O95573-1", "P33121-1", "O60488-1", "Q5FVE4-1", "Q9ULC5-1", "O14975-1", "Q6PCB7-1", "Q6P1M0-1", "Q9Y2P4-1", "Q5K4L6-1", "Q91WC3-1", "Q8JZR0-1", "P41216-1", "Q2XU92-1", "Q9CZW4-1", "Q9QUJ7-1", "O35488-1", "Q60714-1", "E9Q9W4-1", "O88561-1", "Q91VE0-1", "Q9VVT8-1" ], "evidence": [ { "id": "19713", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19713" } ] }, { "id": "30751", "name": "", "equation": "ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl-CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35547-1", "O88813-1", "P18163-1", "A1L1K7-1", "P33124-1", "Q924N5-1", "P97524-1", "Q63151-1", "Q9UKU0-4", "P33121-1", "O60488-1", "Q08AH1-1", "Q96GR2-1", "Q5FVE4-1", "Q9ULC5-1", "O14975-1", "Q6P1M0-1", "Q5K4L6-1", "O95573-1", "Q91WC3-1", "Q91VA0-1", "Q8JZR0-1", "P41216-1", "Q2XU92-1", "Q99PU5-1", "Q9QUJ7-1", "O35488-1", "Q9CZW4-1", "O88561-1", "Q91VE0-1", "P30624-1", "P39002-1", "P39518-1", "P47912-1", "Q9VVT8-1" ], "evidence": [ { "id": "30751", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/30751" } ] }, { "id": "36139", "name": "", "equation": "(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35547-1", "O88813-1", "Q63151-1", "P18163-1", "P33124-1", "Q924N5-1", "P97524-1", "Q9UKU0-4", "O95573-1", "P33121-1", "O60488-1", "Q96GR2-1", "Q9ULC5-1", "O14975-1", "Q6P1M0-1", "Q91WC3-1", "Q8JZR0-1", "P41216-1", "Q99PU5-1", "Q9CZW4-1", "Q9QUJ7-1", "O35488-1", "Q91VE0-1", "Q9VVT8-1" ], "evidence": [ { "id": "36139", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36139" } ] }, { "id": "52008", "name": "", "equation": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA = 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35547-1", "O60488-1", "Q9QUJ7-1" ], "evidence": [ { "id": "52008", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52008" } ] }, { "id": "52012", "name": "", "equation": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35547-1", "O88813-1", "Q63151-1", "O95573-1", "O60488-1", "Q9ULC5-1", "Q8JZR0-1", "Q9CZW4-1", "Q9QUJ7-1" ], "evidence": [ { "id": "52012", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52012" } ] }, { "id": "52016", "name": "", "equation": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35547-1", "O88813-1", "Q63151-1", "P18163-1", "O95573-1", "P33121-1", "O60488-1", "Q9ULC5-1", "Q8JZR0-1", "P41216-1", "Q9CZW4-1", "Q9QUJ7-1" ], "evidence": [ { "id": "52016", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52016" } ] }, { "id": "52088", "name": "", "equation": "5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA = 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35547-1", "O60488-1", "Q9QUJ7-1" ], "evidence": [ { "id": "52088", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52088" } ] }, { "id": "52108", "name": "", "equation": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35547-1", "O88813-1", "Q63151-1", "P18163-1", "P33124-1", "Q9UKU0-4", "O95573-1", "P33121-1", "O60488-1", "Q9ULC5-1", "Q91WC3-1", "Q8JZR0-1", "P41216-1", "Q9CZW4-1", "Q9QUJ7-1", "Q9VVT8-1" ], "evidence": [ { "id": "52108", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52108" } ] }, { "id": "52112", "name": "", "equation": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35547-1", "O88813-1", "Q63151-1", "P18163-1", "P33124-1", "Q9UKU0-4", "O95573-1", "P33121-1", "O60488-1", "Q9ULC5-1", "Q91WC3-1", "Q8JZR0-1", "P41216-1", "Q9CZW4-1", "Q9QUJ7-1", "Q9VVT8-1" ], "evidence": [ { "id": "52112", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52112" } ] }, { "id": "52116", "name": "", "equation": "15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35547-1", "O88813-1", "Q63151-1", "P18163-1", "P33124-1", "Q9UKU0-4", "O95573-1", "P33121-1", "O60488-1", "Q9ULC5-1", "Q91WC3-1", "Q8JZR0-1", "P41216-1", "Q9CZW4-1", "Q9QUJ7-1", "Q9VVT8-1" ], "evidence": [ { "id": "52116", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52116" } ] }, { "id": "R-HSA-434382", "name": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell", "equation": "", "summary": "ACSL3 and ACSL4 found on the mitochondria of pancreatic beta cells ligate coenzyme A (Co-A) to fatty acids such as palmitate (Ansari et al. 2017) prior to transport into mitochondria by the carnitine system and beta oxidation in the mitochondrial matrix yielding ATP.", "cellular_location": "mitochondrial outer membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O60488-1", "O95573-1" ], "evidence": [ { "id": "R-HSA-434382", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-434382" } ] }, { "id": "R-HSA-548843", "name": "ACSL3,4 ligate CoA to AA to form AA-CoA", "equation": "", "summary": "Acyl-CoA synthetase long-chain family member 4 (ACSL4) associated with the endoplasmic reticulum membrane catalyses the conjugation of arachidonate (AA) with CoA to form arachidonyl-CoA (AA-CoA) (Longo et al. 2003, Meloni et al. 2003). By similarity, ACSL3 can also preferentially conjugate CoA on to AA (Yao & Ye 2008). These enzymes are involved in the activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation.", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O60488-1", "O95573-1" ], "evidence": [ { "id": "R-HSA-548843", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-548843" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0B4KFE4", "gene_name": "Acsl", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "A0A0B4KFE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4KFE4" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "A0A0B4KFE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4KFE4" } ] } ] }, { "uniprot_ac": "A1L1K7", "gene_name": "Acsbg2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "A1L1K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1L1K7" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "A1L1K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1L1K7" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "A1L1K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1L1K7" } ] } ] }, { "uniprot_ac": "E9Q9W4", "gene_name": "Slc27a6", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "E9Q9W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q9W4" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "E9Q9W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q9W4" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "E9Q9W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q9W4" } ] } ] }, { "uniprot_ac": "O14975", "gene_name": "SLC27A2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14975" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14975" } ] }, { "ec_number": "6.2.1.7", "activity": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14975" } ] }, { "ec_number": "6.2.1.24", "activity": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA.", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14975" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14975" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14975" } ] } ] }, { "uniprot_ac": "O35488", "gene_name": "Slc27a2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O35488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35488" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "O35488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35488" } ] }, { "ec_number": "6.2.1.7", "activity": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O35488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35488" } ] }, { "ec_number": "6.2.1.24", "activity": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA.", "evidence": [ { "id": "O35488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35488" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O35488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35488" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "O35488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35488" } ] } ] }, { "uniprot_ac": "O35547", "gene_name": "Acsl4", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O35547", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35547" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O35547", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35547" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "O35547", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35547" } ] } ] }, { "uniprot_ac": "O60488", "gene_name": "ACSL4", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O60488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60488" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "O60488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60488" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O60488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60488" } ] } ] }, { "uniprot_ac": "O88561", "gene_name": "Slc27a3", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O88561", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88561" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "O88561", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88561" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "O88561", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88561" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O88561", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88561" } ] } ] }, { "uniprot_ac": "O88813", "gene_name": "Acsl5", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O88813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88813" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O88813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88813" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "O88813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88813" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "O88813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88813" } ] } ] }, { "uniprot_ac": "O95573", "gene_name": "ACSL3", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O95573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95573" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "O95573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95573" } ] }, { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O95573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95573" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O95573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95573" } ] } ] }, { "uniprot_ac": "P18163", "gene_name": "Acsl1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P18163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18163" } ] }, { "ec_number": "6.2.1.24", "activity": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA.", "evidence": [ { "id": "P18163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18163" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P18163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18163" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P18163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18163" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "P18163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18163" } ] } ] }, { "uniprot_ac": "P30624", "gene_name": "FAA1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P30624", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30624" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P30624", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30624" } ] } ] }, { "uniprot_ac": "P33121", "gene_name": "ACSL1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P33121", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33121" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P33121", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33121" } ] }, { "ec_number": "6.2.1.24", "activity": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA.", "evidence": [ { "id": "P33121", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33121" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P33121", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33121" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "P33121", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33121" } ] } ] }, { "uniprot_ac": "P33124", "gene_name": "Acsl6", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P33124", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33124" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P33124", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33124" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P33124", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33124" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "P33124", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33124" } ] } ] }, { "uniprot_ac": "P39002", "gene_name": "FAA3", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P39002", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39002" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P39002", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39002" } ] } ] }, { "uniprot_ac": "P39518", "gene_name": "FAA2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P39518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39518" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P39518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39518" } ] } ] }, { "uniprot_ac": "P41216", "gene_name": "Acsl1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P41216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41216" } ] }, { "ec_number": "6.2.1.24", "activity": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA.", "evidence": [ { "id": "P41216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41216" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P41216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41216" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P41216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41216" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "P41216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41216" } ] } ] }, { "uniprot_ac": "P47912", "gene_name": "FAA4", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P47912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47912" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P47912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47912" } ] } ] }, { "uniprot_ac": "P97524", "gene_name": "Slc27a2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] }, { "ec_number": "6.2.1.7", "activity": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] }, { "ec_number": "6.2.1.24", "activity": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA.", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] } ] }, { "uniprot_ac": "P97849", "gene_name": "Slc27a1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P97849", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97849" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P97849", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97849" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "P97849", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97849" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P97849", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97849" } ] } ] }, { "uniprot_ac": "Q08AH1", "gene_name": "ACSM1", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q08AH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08AH1" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q08AH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08AH1" } ] }, { "ec_number": "6.2.1.25", "activity": "ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate.", "evidence": [ { "id": "Q08AH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08AH1" } ] } ] }, { "uniprot_ac": "Q1ZXQ4", "gene_name": "fcsB", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q1ZXQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1ZXQ4" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q1ZXQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1ZXQ4" } ] } ] }, { "uniprot_ac": "Q2XU92", "gene_name": "Acsbg2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q2XU92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2XU92" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q2XU92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2XU92" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q2XU92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2XU92" } ] } ] }, { "uniprot_ac": "Q4LDG0", "gene_name": "Slc27a5", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q4LDG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4LDG0" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "Q4LDG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4LDG0" } ] }, { "ec_number": "6.2.1.7", "activity": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q4LDG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4LDG0" } ] } ] }, { "uniprot_ac": "Q55DR6", "gene_name": "fcsA", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q55DR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55DR6" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q55DR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55DR6" } ] } ] }, { "uniprot_ac": "Q5FVE4", "gene_name": "ACSBG2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q5FVE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FVE4" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q5FVE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FVE4" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q5FVE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FVE4" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "Q5FVE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FVE4" } ] } ] }, { "uniprot_ac": "Q5K4L6", "gene_name": "SLC27A3", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q5K4L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5K4L6" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q5K4L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5K4L6" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "Q5K4L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5K4L6" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q5K4L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5K4L6" } ] } ] }, { "uniprot_ac": "Q60714", "gene_name": "Slc27a1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q60714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60714" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "Q60714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60714" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q60714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60714" } ] } ] }, { "uniprot_ac": "Q63151", "gene_name": "Acsl3", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q63151", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63151" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q63151", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63151" } ] }, { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q63151", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63151" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q63151", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63151" } ] } ] }, { "uniprot_ac": "Q6P1M0", "gene_name": "SLC27A4", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q6P1M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1M0" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "Q6P1M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1M0" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q6P1M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1M0" } ] } ] }, { "uniprot_ac": "Q6PCB7", "gene_name": "SLC27A1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q6PCB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PCB7" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "Q6PCB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PCB7" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q6PCB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PCB7" } ] } ] }, { "uniprot_ac": "Q8JZR0", "gene_name": "Acsl5", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q8JZR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8JZR0" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q8JZR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8JZR0" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q8JZR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8JZR0" } ] } ] }, { "uniprot_ac": "Q91VA0", "gene_name": "Acsm1", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q91VA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91VA0" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q91VA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91VA0" } ] }, { "ec_number": "6.2.1.25", "activity": "ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate.", "evidence": [ { "id": "Q91VA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91VA0" } ] } ] }, { "uniprot_ac": "Q91VE0", "gene_name": "Slc27a4", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q91VE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91VE0" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "Q91VE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91VE0" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q91VE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91VE0" } ] } ] }, { "uniprot_ac": "Q91WC3", "gene_name": "Acsl6", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q91WC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WC3" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q91WC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WC3" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q91WC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WC3" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "Q91WC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WC3" } ] } ] }, { "uniprot_ac": "Q924N5", "gene_name": "Acsbg1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q924N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q924N5" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q924N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q924N5" } ] } ] }, { "uniprot_ac": "Q96GR2", "gene_name": "ACSBG1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q96GR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96GR2" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q96GR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96GR2" } ] } ] }, { "uniprot_ac": "Q99PU5", "gene_name": "Acsbg1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q99PU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99PU5" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q99PU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99PU5" } ] } ] }, { "uniprot_ac": "Q9CZW4", "gene_name": "Acsl3", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q9CZW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CZW4" } ] }, { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q9CZW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CZW4" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q9CZW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CZW4" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q9CZW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CZW4" } ] } ] }, { "uniprot_ac": "Q9ES38", "gene_name": "Slc27a5", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q9ES38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ES38" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "Q9ES38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ES38" } ] }, { "ec_number": "6.2.1.7", "activity": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q9ES38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ES38" } ] } ] }, { "uniprot_ac": "Q9QUJ7", "gene_name": "Acsl4", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q9QUJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QUJ7" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q9QUJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QUJ7" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q9QUJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QUJ7" } ] } ] }, { "uniprot_ac": "Q9UKU0", "gene_name": "ACSL6", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q9UKU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UKU0" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q9UKU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UKU0" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q9UKU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UKU0" } ] } ] }, { "uniprot_ac": "Q9ULC5", "gene_name": "ACSL5", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q9ULC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ULC5" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q9ULC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ULC5" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q9ULC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ULC5" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "Q9ULC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ULC5" } ] } ] }, { "uniprot_ac": "Q9V3S9", "gene_name": "bgm", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q9V3S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V3S9" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q9V3S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V3S9" } ] } ] }, { "uniprot_ac": "Q9V3U0", "gene_name": "hll", "activity": [ { "ec_number": "6.2.1.3", "activity": "a 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diphosphate.", "evidence": [ { "id": "Q9Y2P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y2P4" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "Q9Y2P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y2P4" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q9Y2P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y2P4" } ] } ] }, { "uniprot_ac": "Q9Y2P5", "gene_name": "SLC27A5", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q9Y2P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y2P5" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q9Y2P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y2P5" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "Q9Y2P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y2P5" } ] }, { "ec_number": "6.2.1.7", "activity": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q9Y2P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y2P5" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 51, 52, 57 ], "snv_sites": [ 232, 236, 312 ], "glycation_sites": [], "phosphorylation_sites": [ 95, 140, 447, 674, 679 ], "sequon_annotation_sites": [ { "start_pos": 194, "end_pos": 196 }, { "start_pos": 525, "end_pos": 527 } ] }, "section_stats": [ { "table_id": 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"table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 40 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }