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"score": "53.11", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000173705", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173705" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "46.96", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000173705", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173705" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "53.87", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000173705", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173705" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "49.96", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000173705", "url": 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O60279", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60279" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60279" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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"categories": [ "Protein" ] }, { "id": "O60279-1", "url": "https://www.uniprot.org/uniprot/O60279-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTAEGPSPPARWHRRLPGLWAAALLLLGLPRLSVRADGKFFVLESQNGSQGLQLEAARLSCKSRGAHLASADELRRVVQDCSFAVCTTGWLADGTLGTTVCSKGSGEQQIMRAVDVRIESNPVPGGTYSALCIKDEEKPCGDPPSFPHTILQGRTGLEMGDELLYVCAPGHIMGHRETAFTLLCNSCGEWYGLVQACGKDEAEAHIDYEDNFPDDRSVSFRELMEDSRTEADEDRGQGDSSEEAPKQDRLVSISVGRENIARDKVFVPTTGLPGAGSSVPADSPGSRLLQKHLFWFPAEAFHKPGLEKEVDDDTKKQFSAGDNHSGVKLVPGEPETKVIYGNTDGPSGPFVGKNDSKAGDPVVSSSDESWLDGYPVTEGAWRKTEAEEEEDGDRGDGSVGLDENVLVTPDQPILVEVKKPKSSTLTPSEGMTHSSVLPSQMLDVEALALRPVNASETEGIGDGDLTKYQSTLPWRFITEESPMATLSYELTSSTLEILTVNTVKQTPNHIPSTIMATTQPPVETTVPEIQDSFPYLLSEDFFGQEGPGPGASEELHPTLESCVGDGCPGLSRGPVIATIVTVLCLLLLLAGVGMVWGYRKCQHKSSVYKLNVGQRQARHYHQQIEMEKV", "length": 629, "header": "sp|O60279-1|SUSD5_HUMAN Isoform 1 of Sushi domain-containing protein 5 OS=Homo sapiens OX=9606 GN=SUSD5 PE=1 SV=3 CANONICAL=O60279-1" }, "isoforms": [ { 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"MTAEGPSPPARWHRRLPGLWAAALLLLGLPRLSVRADGKFFVLESQNGSQGLQLEAARLSCKSRGAHLASADELRRVVQDCSFAVCTTGWLADGTLGTTVCSKGSGEQQIMRAVDVRIESNPVPGGTYSALCIKDEEKPCGDPPSFPHTILQGRTGLEMGDELLYVCAPGHIMGHRETAFTLLCNSCGEWYGLVQACGKDEAEAHIDYEDNFPDDRSVSFRELMEDSRTEADEDRGQGDSSEEAPKQDRLVSISVGRENIARDKVFVPTTGLPGAGSSVPADSPGSRLLQKHLFWFPAEAFHKPGLEKEVDDDTKKQFSAGDNHSGVKLVPGEPETKVIYGNTDGPSGPFVGKNDSKAGDPVVSSSDESWLDGYPVTEGAWRKTEAEEEEDGDRGDGSVGLDENVLVTPDQPILVEVKKPKSSTLTPSEGMTHSSVLPSQMLDVEALALRPVNASETEGIGDGDLTKYQSTLPWRFITEESPMATLSYELTSSTLEILTVNTVKQTPNHIPSTIMATTQPPVETTVPEIQDSFPYLLSEDFFGQEGPGPGASEELHPTLESCVGDGCPGLSRGPVIATIVTVLCLLLLLAGVGMVWGYRKCQHKSSVYKLNVGQRQARHYHQQIEMEKV", "length": 629, "header": "sp|O60279-1|SUSD5_HUMAN Isoform 1 of Sushi domain-containing protein 5 OS=Homo sapiens OX=9606 GN=SUSD5 PE=1 SV=3 CANONICAL=O60279-1" }, "locus": { "chromosome": "3", "start_pos": 33218797, "end_pos": 33152745, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000309558.8", "url": "https://www.ensembl.org/id/ENST00000309558.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000308727.3", "url": "https://www.ensembl.org/id/ENSP00000308727.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "LVSISVGR", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 250, "start_aa": "Leu", "end_pos": 257, "end_aa": "Arg", "evidence": [ { "id": "O60279", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "DKVFVPTTGLPGAGSSVPADSPGSR", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 263, "start_aa": "Asp", "end_pos": 287, "end_aa": "Arg", "evidence": [ { "id": "O60279", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "VFVPTTGLPGAGSSVPADSPGSR", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 265, "start_aa": "Val", "end_pos": 287, "end_aa": "Arg", "evidence": [ { "id": "O60279", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 270, "start_aa": "Thr", "end_pos": 270, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr270", "evidence": [ { "id": "O60279", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G53434XO", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "", "start_pos": 277, "start_aa": "Ser", "end_pos": 277, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser277", "evidence": [ { "id": "O60279", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "", "start_pos": 278, "start_aa": "Ser", "end_pos": 278, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser278", "evidence": [ { "id": "O60279", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 343, "start_aa": "Thr", "end_pos": 343, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr343", "evidence": [ { "id": "O60279", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 343, "start_aa": "Thr", "end_pos": 343, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr343", "evidence": [ { "id": "O60279", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 354, "start_aa": "Asn", "end_pos": 354, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn354", "evidence": [ { "id": "23090970", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23090970" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" }, { "id": "24190977", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24190977" } ] }, { "glytoucan_ac": "G53434XO", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "", "start_pos": 366, "start_aa": "Ser", "end_pos": 366, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser366", "evidence": [ { "id": "O60279", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G29068FM", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 408, "start_aa": "Thr", "end_pos": 408, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr408", "evidence": [ { "id": "O60279", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 408, "start_aa": "Thr", "end_pos": 408, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr408", "evidence": [ { "id": "O60279", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "", "start_pos": 455, "start_aa": "Ser", "end_pos": 455, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser455", "evidence": [ { "id": "O60279", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "YQSTLPWR", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 468, "start_aa": "Tyr", "end_pos": 475, "end_aa": "Arg", "evidence": [ { "id": "O60279", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 470, "start_aa": "Ser", "end_pos": 470, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser470", "evidence": [ { "id": "O60279", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 471, "start_aa": "Thr", "end_pos": 471, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr471", "evidence": [ { "id": "O60279", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 558, "start_aa": "Thr", "end_pos": 558, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr558", "evidence": [ { "id": "O60279", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] } ], "phosphorylation": [ { "start_pos": 105, "end_pos": 105, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O60279", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60279" }, { "database": "PubMed", "id": "18702456", "url": "https://glygen.org/publication/PubMed/18702456" } ], "site_lbl": "Ser105" }, { "start_pos": 227, "end_pos": 227, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O60279", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60279" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ], "site_lbl": "Ser227" }, { "start_pos": 240, "end_pos": 240, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O60279", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60279" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "20187088", "url": "https://glygen.org/publication/PubMed/20187088" } ], "site_lbl": "Ser240" }, { "start_pos": 241, "end_pos": 241, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O60279", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60279" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "20187088", "url": "https://glygen.org/publication/PubMed/20187088" } ], "site_lbl": "Ser241" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan", "glycoprotein_reported" ], "publication": [ { "title": "Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology", "journal": "EMBO J", "date": "2013", "authors": "Steentoft C., Vakhrushev S.Y., Joshi H.J., Kong Y., Vester-Christensen M.B., Schjoldager K.T., Lavrsen K., Dabelsteen S., Pedersen N.B., Marcos-Silva L., Gupta R., Bennett E.P., Mandel U., Brunak S., Wandall H.H., Levery S.B., Clausen H.", "evidence": [ { "database": "UniCarbKB", "id": "O60279", "url": "" } ], "reference": [ { "type": "DOI", "id": "10.1038/emboj.2013.79", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "title": "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.", "journal": "Cell", "date": "2006", "authors": "Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M", "evidence": [ { "database": "iPTMnet", "id": "O60279", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60279" } ], "reference": [ { "type": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ] }, { "title": "Characterization of the human cerebrospinal fluid phosphoproteome by titanium dioxide affinity chromatography and mass spectrometry.", "journal": "Analytical chemistry", "date": "2008", "authors": "Bahl JM, Jensen SS, Larsen MR, Heegaard NH", "evidence": [ { "database": "iPTMnet", "id": "O60279", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60279" } ], "reference": [ { "type": "PubMed", "id": "18702456", "url": "https://glygen.org/publication/PubMed/18702456" } ] }, { "title": "A comprehensive and non-prefractionation on the protein level approach for the human urinary proteome: touching phosphorylation in urine.", "journal": "Rapid communications in mass spectrometry : RCM", "date": "2010", "authors": "Li QR, Fan KX, Li RX, Dai J, Wu CC, Zhao SL, Wu JR, Shieh CH, Zeng R", "evidence": [ { "database": "iPTMnet", "id": "O60279", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60279" } ], "reference": [ { "type": "PubMed", "id": "20187088", "url": "https://glygen.org/publication/PubMed/20187088" } ] }, { "title": "Quantification of the N-glycosylated secretome by super-SILAC during breast cancer progression and in human blood samples.", "journal": "Molecular & cellular proteomics : MCP", "date": "2013", "authors": "Boersema PJ, Geiger T, Wisniewski JR, Mann M", "evidence": [ { "database": "GlyGen", "id": "GLY_000143", "url": "https://data.glygen.org/GLY_000143" } ], "reference": [ { "type": "PubMed", "id": "23090970", "url": "https://glygen.org/publication/PubMed/23090970" } ] }, { "title": "Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology.", "journal": "The EMBO journal", "date": "2013", "authors": "Steentoft C, Vakhrushev SY, Joshi HJ, Kong Y, Vester-Christensen MB, Schjoldager KT, Lavrsen K, Dabelsteen S, Pedersen NB, Marcos-Silva L, Gupta R, Bennett EP, Mandel U, Brunak S, Wandall HH, Levery SB, Clausen H", "evidence": [ { "database": "UniCarbKB", "id": "O60279", "url": "" } ], "reference": [ { "type": "PubMed", "id": "23584533", "url": "https://glygen.org/publication/PubMed/23584533" } ] }, { "title": "N-linked glycosylation enrichment for in-depth cell surface proteomics of diffuse large B-cell lymphoma subtypes.", "journal": "Molecular & cellular proteomics : MCP", "date": "2014", "authors": "Deeb SJ, Cox J, Schmidt-Supprian M, Mann M", "evidence": [ { "database": "GlyGen", "id": "GLY_000143", "url": "https://data.glygen.org/GLY_000143" } ], "reference": [ { "type": "PubMed", "id": "24190977", "url": "https://glygen.org/publication/PubMed/24190977" } ] }, { "title": "Mapping the O-glycoproteome using site-specific extraction of O-linked glycopeptides (EXoO).", "journal": "Molecular systems biology", "date": "2018", "authors": "Yang W, Ao M, Hu Y, Li QK, Zhang H", "evidence": [ { "database": "UniCarbKB", "id": "O60279", "url": "" } ], "reference": [ { "type": "PubMed", "id": "30459171", "url": "https://glygen.org/publication/PubMed/30459171" } ] } ], "pathway": [ { "id": "hsa:26032", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:26032", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZNE4-1", "protein_name": "Sushi domain containing 5", "gene_name": "SUSD5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAERPSSGAWFWAAALLLLGLQRLSVRADGKFFVLESQNGSRGLDLEAAWLSCKSRGAHLASADELRRVVQDCALAVCTTGWLADGNLGTTVCSKGSGEQQIRRAVDMRIESNVVPGSTYNALCIKDEEKPCGDPPSFPHTVLQGRTGLEMGDELLYVCAPGHVTGRRETAFTLLCNSCGEWYGLVQACGKDEAEAHIDYEDNFPDDRSVSFRELMEDSRTEVEEDGGPGDASEEAPKQDRLVSGSVGREDIALDKAFVPTTGLPSAGSSVPTDLPGSRRNQKYLFWFPAEPFHKPALEKEMDDDTKEQFPAGDHQSGTTLAPGEPETRATYGSRGGPSRPFVGRNDSKAVGAVVSGSDESWLDGYPVTDGTWRKPEADEEDEEDKGDGSVGLEESILVKTSPPILVDVKEPMSTTLPPAEDITHGSGLPSQTLDVEALALRPVNVSDTEGPSEGDGDLARYSSTVPWRDTTEKSPMSTLANELPSSTLETGTTAVQKTPNHIPSTATAATQTPVETAAPEVKDTFPYLLSEDFLGQEGAPGPGASEELFPTLEPCAGDKCPGLSRGPIIATIVTVLCLLLFLAGVGAVWGYRKCQHKSSVYKLNAGQRRHYHQQIEMEKV", "length": 622 }, "evidence": [ { "id": "O60279", "url": 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"database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "G3UW60-1", "protein_name": "Sushi domain containing 5", "gene_name": "Susd5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAGPLWPAPGSLPALCAALLLLALQPPPVRAEGKLFMLGSQNGSQGLDLEAARLSCRSRGAHLVSAAELKRVVRDCASAVCTTGWLADGTLGTTVCSKGSGEQPVSRAVDVRIDSHPVPGAKYNALCIKDEERPCGDPPSFPHTILQGRTGLEMGDELLYLCAPGSVPGHRETAFTLLCNSCGEWYGLVQACGKDEAEAHIDYEENFPDDRSVSFRELMEDSRAEGEKEKAQEDASDETPKQDRLVFTSVSKENIAQVKAFVPTTGSPGAGGSVRTDWPRSRLHRKYSLWFPAETFHKPELGKDEGDETKEPLPARDNHSEEKPAPEESETRLVYATTYSPSEPFVDRNDSKAEDPGVSSSDDSWLDGYPVTDGAWRKVEAGQEDDEDKGDGSVGPDESGLTTPDKEPENVTVTPSESVIHSSISPSQMLDVEALVPGPINVSETESSHTRDVDSTSSQSTIPRRVTTQPSPKVTSPHELASSTQETVTTTLQPTHKRTPSTDVEATQPPAGVTAPEVQDNFPYLLSEDFLGQEGPGPGASEKFLPTSAPCVGDECPSFRKGPVIATVVTVLCLLLLLVVAGAVWGYRRCQHKSSVYKLNVGQRQARHYQQQIEMEKV", "length": 619 }, "evidence": [ { "id": "45928042", "url": "http://www.informatics.jax.org/homology/45928042", "database": "MGI" }, { "id": "O60279", "url": "https://omabrowser.org/oma/group/O60279/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "O60279", "url": "https://www.uniprot.org/uniprot/O60279" } ], "pmid": "" }, { "name": "Notch signaling pathway", "id": "GO:0007219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007219", "evidence": [ { "database": "UniProtKB", "id": "O60279", "url": "https://www.uniprot.org/uniprot/O60279" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "O60279", "url": "https://www.uniprot.org/uniprot/O60279" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "hyaluronic acid binding", "id": "GO:0005540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005540", "evidence": [ { "database": "UniProtKB", "id": "O60279", "url": "https://www.uniprot.org/uniprot/O60279" } ], "pmid": "" } ] } ] }, "pro_annotation": [ { "name": "sushi domain-containing protein 5 O-glycosylated 1 (human)", "definition": "A sushi domain-containing protein 5 (human) that has been O-glycosylated at the residue equivalent to Ser-277 of the amino acid sequence represented by UniProtKB:O60279-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:O60279-1, Ser-277, MOD:00002~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050760", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050760" } ] }, { "name": "sushi domain-containing protein 5 O-glycosylated 2 (human)", "definition": "A sushi domain-containing protein 5 (human) that has been O-glycosylated at the residue equivalent to Ser-278 of the amino acid sequence represented by UniProtKB:O60279-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O60279-1, Ser-278, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050761", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050761" } ] }, { "name": "sushi domain-containing protein 5 O-glycosylated 3 (human)", "definition": "A sushi domain-containing protein 5 (human) that has been O-glycosylated at the residue equivalent to Ser-366 of the amino acid sequence represented by UniProtKB:O60279-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:O60279-1, Ser-366, MOD:00002~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050762", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050762" } ] }, { "name": "sushi domain-containing protein 5 O-glycosylated 4 (human)", "definition": "A sushi domain-containing protein 5 (human) that has been O-glycosylated at the residue equivalent to Ser-455 of the amino acid sequence represented by UniProtKB:O60279-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O60279-1, Ser-455, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050763", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050763" } ] }, { "name": "sushi domain-containing protein 5 O-glycosylated 5 (human)", "definition": "A sushi domain-containing protein 5 (human) that has been O-glycosylated at the residue equivalent to Thr-270 of the amino acid sequence represented by UniProtKB:O60279-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O60279-1, Thr-270, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050764", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050764" } ] }, { "name": "sushi domain-containing protein 5 O-glycosylated 6 (human)", "definition": "A sushi domain-containing protein 5 (human) that has been O-glycosylated at the residue equivalent to Thr-343 of the amino acid sequence represented by UniProtKB:O60279-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O60279-1, Thr-343, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050765", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050765" } ] }, { "name": "sushi domain-containing protein 5 O-glycosylated 7 (human)", "definition": "A sushi domain-containing protein 5 (human) that has been O-glycosylated at the residue equivalent to Thr-408 of the amino acid sequence represented by UniProtKB:O60279-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:O60279-1, Thr-408, MOD:00005~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050766", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050766" } ] }, { "name": "sushi domain-containing protein 5 O-glycosylated 8 (human)", "definition": "A sushi domain-containing protein 5 (human) that has been O-glycosylated at the residue equivalent to Thr-408 of the amino acid sequence represented by UniProtKB:O60279-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O60279-1, Thr-408, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050767", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050767" } ] }, { "name": "sushi domain-containing protein 5 O-glycosylated 9 (human)", "definition": "A sushi domain-containing protein 5 (human) that has been O-glycosylated at the residue equivalent to Thr-558 of the amino acid sequence represented by UniProtKB:O60279-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O60279-1, Thr-558, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050768", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050768" } ] } ], "site_annotation": [ { "start_pos": 323, "end_pos": 325, "annotation": "n_glycosylation_sequon" }, { "start_pos": 354, "end_pos": 356, "annotation": "n_glycosylation_sequon" }, { "start_pos": 453, "end_pos": 455, "annotation": "n_glycosylation_sequon" }, { "start_pos": 47, "end_pos": 49, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [ 354 ], "o_linked_sites": [ 250, 263, 265, 270, 277, 278, 343, 366, 408, 455, 468, 470, 471, 558 ], "snv_sites": [ 145, 213, 277, 278, 343, 354, 396, 408, 421, 422, 455, 470, 513, 558, 604 ], "glycation_sites": [], "phosphorylation_sites": [ 105, 227, 240, 241 ], "sequon_annotation_sites": [ { "start_pos": 323, "end_pos": 325 }, { "start_pos": 354, "end_pos": 356 }, { "start_pos": 453, "end_pos": 455 }, { "start_pos": 47, "end_pos": 49 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 17 }, { "field": "total_sites", "count": 12 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 4 }, { "field": "o_linked_glycan_sites", "count": 11 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 16 }, { "field": "total_sites", "count": 11 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 4 }, { "field": "o_linked_glycan_sites", "count": 11 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 19 }, { "field": "total_sites", "count": 15 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 15 }, { "field": "total_sites", "count": 12 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 8 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }