{ "uniprot_canonical_ac": "O43915-1", "uniprot_ac": "O43915", "uniprot_id": "VEGFD_HUMAN", "mass": { "chemical_mass": 40444.0, "monoisotopic_mass": 40444.0 }, "refseq": { "ac": "NP_004460", "name": "vascular endothelial growth factor D preproprotein", "summary": "The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004460" }, "gene_names": [ { "name": "VEGFD", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O43915", "id": "O43915" }, { "name": "FIGF; VEGF-D", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004460", "id": "NP_004460" }, { "name": "FIGF", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O43915", "id": "O43915" }, { "name": "VEGFD", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004460", "id": "NP_004460" } ], "protein_names": [ { "name": "Vascular endothelial growth factor D", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O43915" }, { "name": "FIGF", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43915" }, { "name": "VEGF-D", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43915" }, { "name": "c-Fos-induced growth factor", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43915" }, { "name": "c-fos induced growth factor (vascular endothelial growth factor D)", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004460", "id": "NP_004460" }, { "name": "vascular endothelial growth factor D preproprotein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004460", "id": "NP_004460" } ], "function": [ { "annotation": "Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.", "evidence": [ { "database": "UniProtKB", "id": "O43915", "url": "https://www.uniprot.org/uniprot/O43915#function" }, { "database": "PubMed", "id": "21148085", "url": "https://glygen.org/publication/PubMed/21148085" } ] }, { "annotation": "Serum VEGF-D level is correlated with renal dysfunction and proteinuria in patients with diabetic chronic kidney disease.", "evidence": [ { "database": "RefSeq", "id": "NP_004460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004460" }, { "database": "PubMed", "id": "35363168", "url": "https://glygen.org/publication/PubMed/35363168" } ] }, { "annotation": "The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011].", "evidence": [ { "database": "RefSeq", "id": "NP_004460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004460" } ] }, { "annotation": "VEGF-D-mediated signaling in tendon cells is involved in degenerative processes.", "evidence": [ { "database": "RefSeq", "id": "NP_004460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004460" }, { "database": "PubMed", "id": "35044682", "url": "https://glygen.org/publication/PubMed/35044682" } ] }, { "annotation": "Vascular Endothelial Growth Factor-D (VEGF-D): An Angiogenesis Bypass in Malignant Tumors. Review article Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_004460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004460" }, { "database": "PubMed", "id": "37686121", "url": "https://glygen.org/publication/PubMed/37686121" } ] }, { "annotation": "Vascular endothelial growth factor-D plasma levels and VEGFD genetic variants are independently associated with outcomes in patients with cardiovascular disease. Erratum:[Cardiovasc Res. 2023 Jun 13;119(6):1454. PMID: 36972152]", "evidence": [ { "database": "RefSeq", "id": "NP_004460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004460" }, { "database": "PubMed", "id": "36869765", "url": "https://glygen.org/publication/PubMed/36869765" } ] }, { "annotation": "Vascular endothelial growth factor-D plasma levels in fluid overload and cardiac function evaluation of elderly patients with cardiovascular disease.", "evidence": [ { "database": "RefSeq", "id": "NP_004460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004460" }, { "database": "PubMed", "id": "37986336", "url": "https://glygen.org/publication/PubMed/37986336" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "O43915", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O43915" } ], "glycoeffect": [ "n-glyco-sequon-gain", "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 157, "end_pos": 157, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (STS->NTS); n-glyco-sequon-loss (NTS->NTN).", "chr_id": "X", "chr_pos": "15358025", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "S157", "disease": [ { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "O43915", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O43915" } ], "glycoeffect": [], "start_pos": 108, "end_pos": 108, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "I", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "X", "chr_pos": "15358172", "ref_nt": "C", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "R108", "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. 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] }, { "title": "A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells.", "journal": "The EMBO journal", "date": "2001", "authors": "Takahashi T, Yamaguchi S, Chida K, Shibuya M", "evidence": [ { "database": "Reactome", "id": "R-HSA-195399", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-195399" } ], "reference": [ { "type": "PubMed", "id": "11387210", "url": "https://glygen.org/publication/PubMed/11387210" } ] }, { "title": "Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3.", "journal": "The EMBO journal", "date": "2001", "authors": "Makinen T, Veikkola T, Mustjoki S, Karpanen T, Catimel B, Nice EC, Wise L, Mercer A, Kowalski H, Kerjaschki D, Stacker SA, Achen MG, Alitalo K", "evidence": [ { "database": "Reactome", "id": "R-HSA-195399", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-195399" } ], "reference": [ { "type": "PubMed", "id": "11532940", "url": "https://glygen.org/publication/PubMed/11532940" } ] }, { "title": "Prognostic significance of vascular endothelial growth factor D in breast carcinoma with long-term follow-up.", "journal": "Clinical cancer research : an official journal of the American Association for Cancer Research", "date": "2003", "authors": "Nakamura Y, Yasuoka H, Tsujimoto M, Yang Q, Imabun S, Nakahara M, Nakao K, Nakamura M, Mori I, Kakudo K", "evidence": [ { "database": "GlyGen", "id": "A0101", "url": "https://data.glygen.org/GLY_000625" } ], "reference": [ { "type": "PubMed", "id": "12576440", "url": "https://glygen.org/publication/PubMed/12576440" } ] }, { "title": "Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders.", "journal": "Journal of thrombosis and haemostasis : JTH", "date": 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endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Ito N, Wernstedt C, Engstrom U, Claesson-Welsh L", "evidence": [ { "database": "Reactome", "id": "R-HSA-195399", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-195399" } ], "reference": [ { "type": "PubMed", "id": "9722576", "url": "https://glygen.org/publication/PubMed/9722576" } ] } ], "pathway": [ { "id": "hsa:2277", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:2277", "resource": "KEGG Pathway" }, { "id": "R-HSA-114608", "name": "Platelet degranulation", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-114608", "resource": "Reactome", "description": "Platelet degranulation" }, { "id": "R-HSA-194313", "name": "VEGF ligand-receptor interactions", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-194313", "resource": "Reactome", 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