{ "uniprot_canonical_ac": "O43670-1", "uniprot_ac": "O43670", "uniprot_id": "ZN207_HUMAN", "mass": { "chemical_mass": 50751.0, "monoisotopic_mass": 50751.0 }, "refseq": { "ac": "NP_001027464", "name": "BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform b", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027464" }, "gene_names": [ { "name": "ZNF207", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O43670", "id": "O43670" }, { "name": "BUGZ", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O43670", "id": "O43670" }, { "name": "BuGZ; hBuGZ", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027464", "id": "NP_001027464" }, { "name": "ZNF207", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027464", "id": "NP_001027464" } ], "protein_names": [ { "name": "BUB3-interacting and GLEBS motif-containing protein ZNF207", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O43670" }, { "name": "BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027464", "id": "NP_001027464" }, { "name": "BUB3-interacting and GLEBS motif-containing protein ZNF207", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027464", "id": "NP_001027464" }, { "name": "BuGZ", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43670" }, { "name": "Zinc finger protein 207", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43670" }, { "name": "hBuGZ", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43670" } ], "function": [ { "annotation": "A distinct isoform of ZNF207 functions in hESCs at the nexus that balances pluripotency and differentiation to ectoderm. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001027464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027464" }, { "database": "PubMed", "id": "30349051", "url": "https://glygen.org/publication/PubMed/30349051" } ] }, { "annotation": "BuGZ facilitates loading of spindle assembly checkpoint proteins to kinetochores in early mitosis.", "evidence": [ { "database": "RefSeq", "id": "NP_001027464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027464" }, { "database": "PubMed", "id": "32820050", "url": "https://glygen.org/publication/PubMed/32820050" } ] }, { "annotation": "Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).", "evidence": [ { "database": "UniProtKB", "id": "O43670", "url": "https://www.uniprot.org/uniprot/O43670#function" }, { "database": "PubMed", "id": "24462186", "url": "https://glygen.org/publication/PubMed/24462186" }, { "database": "PubMed", "id": "24462187", "url": "https://glygen.org/publication/PubMed/24462187" }, { "database": "PubMed", "id": "26388440", "url": "https://glygen.org/publication/PubMed/26388440" } ] }, { "annotation": "SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3.", "evidence": [ { "database": "RefSeq", "id": "NP_001027464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027464" }, { "database": "PubMed", "id": "37535603", "url": "https://glygen.org/publication/PubMed/37535603" } ] }, { "annotation": "System analysis based on the cancer-immunity cycle identifies ZNF207 as a novel immunotherapy target for hepatocellular carcinoma.", "evidence": [ { "database": "RefSeq", "id": "NP_001027464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027464" }, { "database": "PubMed", "id": "35246476", "url": "https://glygen.org/publication/PubMed/35246476" } ] }, { "annotation": "ZNF207 expression is elevated in hepatocellular carcinoma", "evidence": [ { "database": "RefSeq", "id": "NP_001027464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027464" }, { "database": "PubMed", "id": "31113916", "url": "https://glygen.org/publication/PubMed/31113916" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs1163578242", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1163578242" }, { "id": "rs1163578242", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1163578242#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 326, "end_pos": 326, "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (TQS->NQS); o-glyco-site-loss (T->N).", "chr_id": "17", "chr_pos": "32367827", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T326", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1380616343", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1380616343" }, { "id": "rs1380616343", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1380616343#frequency_tab" }, { "id": "rs1380616343", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1380616343" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 263, "end_pos": 263, "sequence_org": "T", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->A).", "chr_id": "17", "chr_pos": "32366671", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T263", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O43670", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O43670" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 267, "end_pos": 267, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "R", "comment": "Somatic mutation passed 1 out of 6 filters: o-glyco-site-loss (S->R).", "chr_id": "17", "chr_pos": "32366685", "ref_nt": "C", "alt_nt": "G", "minor_allelic_frequency": "", "site_lbl": "S267", "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs755566311", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs755566311" }, { "id": "rs755566311", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs755566311" }, { "id": "rs755566311", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs755566311#frequency_tab" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 309, "end_pos": 309, "sequence_org": "S", "sequence_mut": "G", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->G).", "chr_id": "17", "chr_pos": "32367823", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S309", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O43670", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O43670" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 309, "end_pos": 309, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: o-glyco-site-loss (S->N).", "chr_id": "17", "chr_pos": "32367824", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "S309", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs1163578242", "database": 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"chr_id": "17", "chr_pos": "32367836", "ref_nt": "C", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "T313", "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs1248036684", 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL 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"name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, 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"http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "O43670", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43670" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "O43670", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43670" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "O43670", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43670" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": 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"url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23215:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "O43670", "url": "https://pharos.nih.gov/targets/O43670", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O43670", "url": "http://purl.obolibrary.org/obo/PR_O43670", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001027464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027464", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "H0Y3M2", "url": "https://www.uniprot.org/uniprot/H0Y3M2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y3M2-1", "url": "https://www.uniprot.org/uniprot/H0Y3M2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3KRB6", "url": "https://www.uniprot.org/uniprot/J3KRB6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3KRB6-1", "url": "https://www.uniprot.org/uniprot/J3KRB6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3KRW6", "url": "https://www.uniprot.org/uniprot/J3KRW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3KRW6-1", "url": "https://www.uniprot.org/uniprot/J3KRW6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3KS31", "url": "https://www.uniprot.org/uniprot/J3KS31", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3KS31-1", "url": "https://www.uniprot.org/uniprot/J3KS31-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3KTL1", "url": "https://www.uniprot.org/uniprot/J3KTL1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3KTL1-1", "url": "https://www.uniprot.org/uniprot/J3KTL1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3QRS9", "url": "https://www.uniprot.org/uniprot/J3QRS9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3QRS9-1", "url": "https://www.uniprot.org/uniprot/J3QRS9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3QS27", "url": "https://www.uniprot.org/uniprot/J3QS27", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3QS27-1", "url": "https://www.uniprot.org/uniprot/J3QS27-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O43670", "url": "https://www.uniprot.org/uniprot/O43670", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O43670-1", "url": "https://www.uniprot.org/uniprot/O43670-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O43670-2", "url": "https://www.uniprot.org/uniprot/O43670-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O43670-3", "url": "https://www.uniprot.org/uniprot/O43670-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O43670-4", "url": "https://www.uniprot.org/uniprot/O43670-4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "X6R4W8", "url": "https://www.uniprot.org/uniprot/X6R4W8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "X6R4W8-1", "url": "https://www.uniprot.org/uniprot/X6R4W8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRKKKKQLKPWCWYCNRDFDDEKILIQHQKAKHFKCHICHKKLYTGPGLAIHCMQVHKETIDAVPNAIPGRTDIELEIYGMEGIPEKDMDERRRLLEQKTQESQKKKQQDDSDEYDDDDSAASTSFQPQPVQPQQGYIPPMAQPGLPPVPGAPGMPPGIPPLMPGVPPLMPGMPPVMPGMPPGMMPMGGMMPPGPGIPPLMPGMPPGMPPPVPRPGIPPMTQAQAVSAPGILNRPPAPTATVPAPQPPVTKPLFPSAGQMGTPVTSSSTASSNSESLSASSKALFPSTAQAQAAVQGPVGTDFKPLNSTPATTTEPPKPTFPAYTQSTASTTSTTNSTAAKPAASITSKPATLTTTSATSKLIHPDEDISLEERRAQLPKYQRNLPRPGQAPIGNPPVGPIGGMMPPQPGIPQQQGMRPPMPPHGQYGGHHQGMPGYLPGAMPPYGQGPPMVPPYQGGPPRPPMGMRPPVMSQGGRY", "length": 478, "header": "sp|O43670-1|ZN207_HUMAN Isoform 1 of BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=1 CANONICAL=O43670-1" }, "isoforms": [ { "isoform_ac": "H0Y3M2-1", "url": "", "sequence": { "sequence": "MQVHKETIDAVPNAIPGRTDIELEIYGMEGIPEKDMDERRRLLEQKTQESQKKKQQDDSDEYDDDDSAASTSFQPQPVQPQQGYIPPMAQPGLPPVPGAPGMPPGIPPLMPGVPPLMPGMPPVMPGMPPGLHHQRKYTQSFCGENIMMPMGGMMPPGPGIPPLMPGMPPGMPPPVPRPGIPPMTQAQAVSAPGILNRP", "length": 198, "header": "tr|H0Y3M2-1|ZN207_HUMAN Computationally mapped isoform of BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=2 CANONICAL=O43670-1" }, "locus": { "chromosome": "17", "start_pos": 32365415, "end_pos": 32351907, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000394679.9", "url": "https://www.ensembl.org/id/ENST00000394679.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000378172.5", "url": "https://www.ensembl.org/id/ENSP00000378172.5" } ] } }, { "isoform_ac": "J3KRB6-1", "url": "", "sequence": { "sequence": "MQVHKETIDAVPNAIPGRTDIELEIYGMEGIPEKDMDERRRLLEQKTQESQKKKQQDDSDEYDDDDSAASTSFQPQPVQPQQGYIPPMAQPGL", "length": 93, "header": "tr|J3KRB6-1|J3KRB6_HUMAN Computationally mapped isoform of Zinc finger protein 207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=1 CANONICAL=O43670-1" }, "locus": { "chromosome": "17", "start_pos": 32360731, "end_pos": 32351907, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000580759.5", "url": "https://www.ensembl.org/id/ENST00000580759.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000461914.1", "url": "https://www.ensembl.org/id/ENSP00000461914.1" } ] } }, { "isoform_ac": "J3KRW6-1", "url": "", "sequence": { "sequence": "MQVHKETIDAVPNAIPGRTDIELEIYGMEGIPEKDMDERRRLLEQKTQESQKKKQQDDSDEYDDDDSAASTSFQPQPVQPQQGYIPPMAQPGLPP", "length": 95, "header": "tr|J3KRW6-1|J3KRW6_HUMAN Computationally mapped isoform of Zinc finger protein 207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=8 CANONICAL=O43670-1" }, "locus": { "chromosome": "17", "start_pos": 32360737, "end_pos": 32351907, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000582165.1", "url": "https://www.ensembl.org/id/ENST00000582165.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000462193.1", "url": "https://www.ensembl.org/id/ENSP00000462193.1" } ] } }, { "isoform_ac": "J3KS31-1", "url": "", "sequence": { "sequence": "XGMPPGIPPLMPGVPPLMPGMPPVMPGMPPGLHHQRKYTQSFCGENIMMPMGGMMPPGPGIPPLMPGMPPGMPPPVPRPGIPPMTQAQAVSAPGILNRPPAPTATVPAPQPPVTKPLFPSAGQMGTPVTSSSTASSNSESLSASSKALFPSTAQAQAAVQGPVGTDFKPLNSTPATTTEPPKPTFPAYTQSTASTTSTTNSTAAKPAASITSKPATLTTTSATSKLIHPDEDISLEERRAQLPKYQRNLPRPGQAPIGNPPVGPIGGMMPPQPGIPQQQGMRPPMPPHGQYGGHHQGMPGYLPGAMPPYGQGPPMVPPYQGGPPRPPMGMRPPVMSQGGRY", "length": 341, "header": "tr|J3KS31-1|ZN207_HUMAN Computationally mapped isoform of BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=1 CANONICAL=O43670-1" }, "locus": { "chromosome": "17", "start_pos": 32369757, "end_pos": 32360751, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000581531.5", "url": "https://www.ensembl.org/id/ENST00000581531.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000462284.1", "url": "https://www.ensembl.org/id/ENSP00000462284.1" } ] } }, { "isoform_ac": "J3KTL1-1", "url": "", "sequence": { "sequence": "MQVHKETIDAVPNAIPGRTDIELEIYGMEGIPEKDMDERRRLLEQKTQESQKKKQQDDSDEYDDDDSAASTSFQ", "length": 74, "header": "tr|J3KTL1-1|ZN207_HUMAN Computationally mapped isoform of BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=1 CANONICAL=O43670-1" }, "locus": { "chromosome": "17", "start_pos": 32360674, "end_pos": 32351907, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000579634.5", "url": "https://www.ensembl.org/id/ENST00000579634.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000463040.1", "url": "https://www.ensembl.org/id/ENSP00000463040.1" } ] } }, { "isoform_ac": "J3QRS9-1", "url": "", "sequence": { "sequence": "MGRKKKKQLKPWCWYCNRDFDDEKILIQHQKAKHFKCHICHKKLYTGPGLAIHCMQVHKETIDAVPNAIPGRTDIELEIYGMEGIPEKDMDERRRLLEQKTQESQKKKQQDDSDEYDDDDSAASTSFQPQPVQPQQGYIPPMAQPGLPPVPGAPGMPPGIPPLMPGVPPLMPGMPPVMPGMPPGLHHQRKYTQSFCGENIMMPMGGMMPPGPGIPPLMPGMPPGMPPPVPRPGIPPMTQAQAVSAPGILNRPPAPTATVPAPQPPVTKPLFPSAGQMGTPVTSSSTASSNSESLSASSKALFPSTAQAQAAVQGPVGTDFKPLNSTPATTTEPPKPTFPAYTQSTASTTSTTNSTAAKPAASITSKPATLTTTSATSKLIHPDEDISLEERRAQLPKYQRNLPRPGQAPIGNPPVGPIGGMMPPQPGIPQQQGMRPPMPPHGQYGGHHQGMPGYLPGAMPPYGQGPPMVPPYQGGPPRPPMGMRPPVMSQALP", "length": 493, "header": "tr|J3QRS9-1|ZN207_HUMAN Computationally mapped isoform of BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=1 CANONICAL=O43670-1" }, "locus": { "chromosome": "17", "start_pos": 32373406, "end_pos": 32350286, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000577908.5", "url": "https://www.ensembl.org/id/ENST00000577908.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000464366.1", "url": "https://www.ensembl.org/id/ENSP00000464366.1" } ] } }, { "isoform_ac": "J3QS27-1", "url": "", "sequence": { "sequence": "MQVHKETIDAVPNAIPGRTDIELEIYGMEGIPEKDMDERRRLLEQK", "length": 46, "header": "tr|J3QS27-1|ZN207_HUMAN Computationally mapped isoform of BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=1 CANONICAL=O43670-1" }, "locus": { "chromosome": "17", "start_pos": 32358634, "end_pos": 32351907, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000578918.1", "url": "https://www.ensembl.org/id/ENST00000578918.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000464495.1", "url": "https://www.ensembl.org/id/ENSP00000464495.1" } ] } }, { "isoform_ac": "O43670-1", "url": "", "sequence": { "sequence": "MGRKKKKQLKPWCWYCNRDFDDEKILIQHQKAKHFKCHICHKKLYTGPGLAIHCMQVHKETIDAVPNAIPGRTDIELEIYGMEGIPEKDMDERRRLLEQKTQESQKKKQQDDSDEYDDDDSAASTSFQPQPVQPQQGYIPPMAQPGLPPVPGAPGMPPGIPPLMPGVPPLMPGMPPVMPGMPPGMMPMGGMMPPGPGIPPLMPGMPPGMPPPVPRPGIPPMTQAQAVSAPGILNRPPAPTATVPAPQPPVTKPLFPSAGQMGTPVTSSSTASSNSESLSASSKALFPSTAQAQAAVQGPVGTDFKPLNSTPATTTEPPKPTFPAYTQSTASTTSTTNSTAAKPAASITSKPATLTTTSATSKLIHPDEDISLEERRAQLPKYQRNLPRPGQAPIGNPPVGPIGGMMPPQPGIPQQQGMRPPMPPHGQYGGHHQGMPGYLPGAMPPYGQGPPMVPPYQGGPPRPPMGMRPPVMSQGGRY", "length": 478, "header": "sp|O43670-1|ZN207_HUMAN Isoform 1 of BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=1 CANONICAL=O43670-1" }, "locus": { "chromosome": "17", "start_pos": 32369756, "end_pos": 32350286, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000321233.10", "url": "https://www.ensembl.org/id/ENST00000321233.10" }, { "database": "Ensembl Peptide", "id": "ENSP00000322777.6", "url": "https://www.ensembl.org/id/ENSP00000322777.6" } ] } }, { "isoform_ac": "O43670-2", "url": "", "sequence": { "sequence": "MGRKKKKQLKPWCWYCNRDFDDEKILIQHQKAKHFKCHICHKKLYTGPGLAIHCMQVHKETIDAVPNAIPGRTDIELEIYGMEGIPEKDMDERRRLLEQKTQESQKKKQQDDSDEYDDDDSAASTSFQPQPVQPQQGYIPPMAQPGLPPVPGAPGMPPGIPPLMPGVPPLMPGMPPVMPGMPPGLHHQRKYTQSFCGENIMMPMGGMMPPGPGIPPLMPGMPPGMPPPVPRPGIPPMTQAQAVSAPGILNRPPAPTATVPAPQPPVTKPLFPSAGQAQAAVQGPVGTDFKPLNSTPATTTEPPKPTFPAYTQSTASTTSTTNSTAAKPAASITSKPATLTTTSATSKLIHPDEDISLEERRAQLPKYQRNLPRPGQAPIGNPPVGPIGGMMPPQPGIPQQQGMRPPMPPHGQYGGHHQGMPGYLPGAMPPYGQGPPMVPPYQGGPPRPPMGMRPPVMSQGGRY", "length": 463, "header": "sp|O43670-2|ZN207_HUMAN Isoform 2 of BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=1 CANONICAL=O43670-1" }, "locus": { "chromosome": "17", "start_pos": 32369756, "end_pos": 32350286, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000394673.6", "url": "https://www.ensembl.org/id/ENST00000394673.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000378168.2", "url": "https://www.ensembl.org/id/ENSP00000378168.2" } ] } }, { "isoform_ac": "O43670-3", "url": "", "sequence": { "sequence": "MGRKKKKQLKPWCWYCNRDFDDEKILIQHQKAKHFKCHICHKKLYTGLPPVPGAPGMPPGIPPLMPGVPPLMPGMPPVMPGMPPGLHHQRKYTQSFCGENIMMPMGGMMPPGPGIPPLMPGMPPGMPPPVPRPGIPPMTQAQAVSAPGILNRPPAPTATVPAPQPPVTKPLFPSAGQMGTPVTSSSTASSNSESLSASSKALFPSTAQAQAAVQGPVGTDFKPLNSTPATTTEPPKPTFPAYTQSTASTTSTTNSTAAKPAASITSKPATLTTTSATSKLIHPDEDISLEERRAQLPKYQRNLPRPGQAPIGNPPVGPIGGMMPPQPGIPQQQGMRPPMPPHGQYGGHHQGMPGYLPGAMPPYGQGPPMVPPYQGGPPRPPMGMRPPVMSQGGRY", "length": 395, "header": "sp|O43670-3|ZN207_HUMAN Isoform 3 of BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=1 CANONICAL=O43670-1" }, "locus": {} }, { "isoform_ac": "O43670-4", "url": "", "sequence": { "sequence": "MGRKKKKQLKPWCWYCNRDFDDEKILIQHQKAKHFKCHICHKKLYTGPGLAIHCMQVHKETIDAVPNAIPGRTDIELEIYGMEGIPEKDMDERRRLLEQKTQESQKKKQQDDSDEYDDDDSAASTSFQPQPVQPQQGYIPPMAQPGLPPVPGAPGMPPGIPPLMPGVPPLMPGMPPVMPGMPPGLHHQRKYTQSFCGENIMMPMGGMMPPGPGIPPLMPGMPPGMPPPVPRPGIPPMTQAQAVSAPGILNRPPAPTATVPAPQPPVTKPLFPSAGQMGTPVTSSSTASSNSESLSASSKALFPSTAQAQAAVQGPVGTDFKPLNSTPATTTEPPKPTFPAYTQSTASTTSTTNSTAAKPAASITSKPATLTTTSATSKLIHPDEDISLEERRAQLPKYQRNLPRPGQAPIGNPPVGPIGGMMPPQPGIPQQQGMRPPMPPHGQYGGHHQGMPGYLPGAMPPYGQGPPMVPPYQGGPPRPPMGMRPPVMSQGGRY", "length": 494, "header": "sp|O43670-4|ZN207_HUMAN Isoform 4 of BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=1 CANONICAL=O43670-1" }, "locus": { "chromosome": "17", "start_pos": 32369756, "end_pos": 32350286, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000394670.9", "url": "https://www.ensembl.org/id/ENST00000394670.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000378165.4", "url": "https://www.ensembl.org/id/ENSP00000378165.4" } ] } }, { "isoform_ac": "X6R4W8-1", "url": "", "sequence": { "sequence": "MAMSSLGCLCALTVLIRYCNRDFDDEKILIQHQKAKHFKCHICHKKLYTGPGLAIHCMQVHKETIDAVPNAIPGRTDIELEIYGMEGIPEKDMDERRRLLEQKTQESQKKKQQDDSDEYDDDDSAASTSFQPQPVQPQQGYIPPMAQPGLPPVPGAPGMPPGIPPLMPGVPPLMPGMPPVMPGMPPGLHHQRKYTQSFCGENIMMPMGGMMPPGPGIPPLMPGMPPGMPPPVPRPGIPPMTQAQAVSAPGILNRPPAPTATVPAPQPPVTKPLFPSAGQMGTPVTSSSTASSNSESLSASSKALFPSTAQAQAAVQGPVGTDFKPLNSTPATTTEPPKPTFPAYTQSTASTTSTTNSTAAKPAASITSKPATLTTTSATSKLIHPDEDISLEERRAQLPKYQRNLPRPGQAPIGNPPVGPIGGMMPPQPGIPQQQGMRPPMPPHGQYGGHHQGMPGYLPGAMPPYGQGPPMVPPYQGGPPRPPMGMRPPVMSQGGRY", "length": 497, "header": "tr|X6R4W8-1|ZN207_HUMAN Computationally mapped isoform of BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=1 CANONICAL=O43670-1" }, "locus": { "chromosome": "17", "start_pos": 32369756, "end_pos": 32351623, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000342555.10", "url": "https://www.ensembl.org/id/ENST00000342555.10" }, { "database": "Ensembl Peptide", "id": "ENSP00000340029.6", "url": "https://www.ensembl.org/id/ENSP00000340029.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 257, "start_aa": "Ser", "end_pos": 257, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser257", "evidence": [ { "id": "O43670", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43670" }, { "id": "27655845", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27655845" }, { "id": "35008409", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35008409" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "21740066", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/21740066" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34931806", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34931806" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "32119511", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32119511" }, { "id": "29485866", "database": 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"reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 349, "start_aa": "Ser", "end_pos": 349, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser349", "evidence": [ { "id": "O43670", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43670" }, { "id": "27655845", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27655845" }, { "id": "35008409", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35008409" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "21740066", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/21740066" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34931806", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34931806" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "32119511", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32119511" }, { "id": "29485866", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29485866" }, { "id": "20305658", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/20305658" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "O43670", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O43670" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc.", "journal": "Nature chemical biology", "date": "2010", "authors": "Teo CF, Ingale S, Wolfert MA, Elsayed GA, Not LG, Chatham JC, Wells L, Boons GJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43670", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43670" } ], "reference": [ { "type": "PubMed", "id": "20305658", "url": "https://glygen.org/publication/PubMed/20305658" } ] }, { "title": "Combining high-energy C-trap dissociation and electron transfer dissociation for protein O-GlcNAc modification site assignment.", "journal": "Journal of proteome research", "date": "2011", "authors": "Zhao P, Viner R, Teo CF, Boons GJ, Horn D, Wells L", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43670", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43670" } ], "reference": [ { "type": "PubMed", "id": "21740066", "url": "https://glygen.org/publication/PubMed/21740066" } ] }, { "title": "A microtubule-associated zinc finger protein, BuGZ, regulates mitotic chromosome alignment by ensuring Bub3 stability and kinetochore targeting.", "journal": "Developmental cell", "date": "2014", "authors": "Jiang H, He X, Wang S, Jia J, Wan Y, Wang Y, Zeng R, Yates J 3rd, Zhu X, Zheng Y", "evidence": [ { "database": "UniProtKB", "id": "O43670", "url": "https://www.uniprot.org/uniprot/O43670" } ], "reference": [ { "type": "PubMed", "id": "24462186", "url": "https://glygen.org/publication/PubMed/24462186" } ] }, { "title": "BuGZ is required for Bub3 stability, Bub1 kinetochore function, and chromosome alignment.", "journal": "Developmental cell", "date": "2014", "authors": "Toledo CM, Herman JA, Olsen JB, Ding Y, Corrin P, Girard EJ, Olson JM, Emili A, DeLuca JG, Paddison PJ", "evidence": [ { "database": "UniProtKB", "id": "O43670", "url": "https://www.uniprot.org/uniprot/O43670" } ], "reference": [ { "type": "PubMed", "id": "24462187", "url": "https://glygen.org/publication/PubMed/24462187" } ] }, { "title": "Phase transition of spindle-associated protein regulate spindle apparatus assembly.", "journal": "Cell", "date": "2015", "authors": "Jiang H, Wang S, Huang Y, He X, Cui H, Zhu X, Zheng Y", "evidence": [ { "database": "UniProtKB", "id": "O43670", "url": "https://www.uniprot.org/uniprot/O43670" } ], "reference": [ { "type": "PubMed", "id": "26388440", "url": "https://glygen.org/publication/PubMed/26388440" } ] }, { "title": "Global Analysis of O-GlcNAc Glycoproteins in Activated Human T Cells.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2016", "authors": "Lund PJ, Elias JE, Davis MM", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43670", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43670" } ], "reference": [ { "type": "PubMed", "id": "27655845", "url": "https://glygen.org/publication/PubMed/27655845" } ] }, { "title": "Synthesis of a Highly Azide-Reactive and Thermosensitive Biofunctional Reagent for Efficient Enrichment and Large-Scale Identification of O-GlcNAc Proteins by Mass Spectrometry.", "journal": "Analytical chemistry", "date": "2017", "authors": "Zhang W, Liu T, Dong H, Bai H, Tian F, Shi Z, Chen M, Wang J, Qin W, Qian X", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43670", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43670" } ], "reference": [ { "type": "PubMed", "id": "28510447", "url": "https://glygen.org/publication/PubMed/28510447" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43670", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43670" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43670", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43670" }, { "database": "O-GlcNAc Atlas", "id": "O43670", "url": "https://oglcnac.org/atlas/detail/O43670" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "O-GlcNAc Transferase Recognizes Protein Substrates Using an Asparagine Ladder in the Tetratricopeptide Repeat (TPR) Superhelix.", "journal": "Journal of the American Chemical Society", "date": "2018", "authors": "Levine ZG, Fan C, Melicher MS, Orman M, Benjamin T, Walker S", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43670", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43670" } ], "reference": [ { "type": "PubMed", "id": "29485866", "url": "https://glygen.org/publication/PubMed/29485866" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43670", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43670" }, { "database": "O-GlcNAc Atlas", "id": "O43670", "url": "https://oglcnac.org/atlas/detail/O43670" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "A distinct isoform of ZNF207 controls self-renewal and pluripotency of human embryonic stem cells.", "journal": "Nature communications", "date": "2018", "authors": "Fang F, Xia N, Angulo B, Carey J, Cady Z, Durruthy-Durruthy J, Bennett T, Sebastiano V, Reijo Pera RA", "evidence": [ { "database": "RefSeq", "id": "NP_001027464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027464" } ], "reference": [ { "type": "PubMed", "id": "30349051", "url": "https://glygen.org/publication/PubMed/30349051" } ] }, { "title": "[Expression of ZNF207 in hepatocellular carcinoma and its significance].", "journal": "Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences", "date": "2019", "authors": "Zhou C, Li N", "evidence": [ { "database": "RefSeq", "id": "NP_001027464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027464" } ], "reference": [ { "type": "PubMed", "id": "31113916", "url": "https://glygen.org/publication/PubMed/31113916" } ] }, { "title": "Engineering a Proximity-Directed O-GlcNAc Transferase for Selective Protein O-GlcNAcylation in Cells.", "journal": "ACS chemical biology", "date": "2020", "authors": "Ramirez DH, Aonbangkhen C, Wu HY, Naftaly JA, Tang S, O'Meara TR, Woo CM", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43670", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43670" } ], "reference": [ { "type": "PubMed", "id": "32119511", "url": "https://glygen.org/publication/PubMed/32119511" } ] }, { "title": "BuGZ facilitates loading of spindle assembly checkpoint proteins to kinetochores in early mitosis.", "journal": "The Journal of biological chemistry", "date": "2020", "authors": "Shirnekhi HK, Herman JA, Paddison PJ, DeLuca JG", "evidence": [ { "database": "RefSeq", "id": "NP_001027464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027464" } ], "reference": [ { "type": "PubMed", "id": "32820050", "url": "https://glygen.org/publication/PubMed/32820050" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43670", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43670" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43670", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43670" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Truncation of the TPR domain of OGT alters substrate and glycosite selection.", "journal": "Analytical and bioanalytical chemistry", "date": "2021", "authors": "Ramirez DH, Yang B, D'Souza AK, Shen D, Woo CM", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43670", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43670" } ], "reference": [ { "type": "PubMed", "id": "34725712", "url": "https://glygen.org/publication/PubMed/34725712" } ] }, { "title": "4-Deoxy-4-fluoro-GalNAz (4FGalNAz) Is a Metabolic Chemical Reporter of O-GlcNAc Modifications, Highlighting the Notable Substrate Flexibility of O-GlcNAc Transferase.", "journal": "ACS chemical biology", "date": "2022", "authors": "Jackson EG, Cutolo G, Yang B, Yarravarapu N, Burns MWN, Bineva-Todd G, Roustan C, Thoden JB, Lin-Jones HM, van Kuppevelt TH, Holden HM, Schumann B, Kohler JJ, Woo CM, Pratt MR", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43670", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43670" } ], "reference": [ { "type": "PubMed", "id": "34931806", "url": "https://glygen.org/publication/PubMed/34931806" } ] }, { "title": "Comparative O-GlcNAc Proteomic Analysis Reveals a Role of O-GlcNAcylated SAM68 in Lung Cancer Aggressiveness.", "journal": "Cancers", "date": "2022", "authors": "Lin CH, Liao CC, Wang SY, Peng CY, Yeh YC, Chen MY, Chou TY", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43670", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43670" } ], "reference": [ { "type": "PubMed", "id": "35008409", "url": "https://glygen.org/publication/PubMed/35008409" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43670", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43670" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "Spatiotemporal Activation of Protein O-GlcNAcylation in Living Cells.", "journal": "Journal of the American Chemical Society", "date": "2022", "authors": "He J, Fan Z, Tian Y, Yang W, Zhou Y, Zhu Q, Zhang W, Qin W, Yi W", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43670", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43670" } ], "reference": [ { "type": "PubMed", "id": "35138101", "url": "https://glygen.org/publication/PubMed/35138101" } ] }, { "title": "System analysis based on the cancer-immunity cycle identifies ZNF207 as a novel immunotherapy target for hepatocellular carcinoma.", "journal": "Journal for immunotherapy of cancer", "date": "2022", "authors": "Wang X, Zhou T, Chen X, Wang Y, Ding Y, Tu H, Gao S, Wang H, Tang X, Yang Y", "evidence": [ { "database": "RefSeq", "id": "NP_001027464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027464" } ], "reference": [ { "type": "PubMed", "id": "35246476", "url": "https://glygen.org/publication/PubMed/35246476" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43670", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43670" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43670", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43670" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3.", "journal": "EMBO reports", "date": "2023-10-09", "authors": "Perlee Sarah, Kikuchi Sota, Nakadai Tomoyoshi, Masuda Takeshi, Ohtsuki Sumio, Matsumoto Makoto, Rahmutulla Bahityar, Fukuyo Masaki, Cifani Paolo, Kentsis Alex, Roeder Robert G, Kaneda Atsushi, Hoshii Takayuki", "evidence": [ { "database": "RefSeq", "id": "NP_001027464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027464" } ], "reference": [ { "type": "PubMed", "id": "37535603", "url": "https://glygen.org/publication/PubMed/37535603" } ] }, { "title": "ZNF207, a ubiquitously expressed zinc finger gene on chromosome 6p21.3.", "journal": "Genomics", "date": "1998", "authors": "Pahl P M, Hodges Y K, Meltesen L, Perryman M B, Horwitz K B, Horwitz L D", "evidence": [ { "database": "UniProtKB", "id": "O43670", "url": "https://www.uniprot.org/uniprot/O43670" } ], "reference": [ { "type": "PubMed", "id": "9799612", "url": "https://glygen.org/publication/PubMed/9799612" } ] } ], "pathway": [ { "id": "hsa:7756", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:7756", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q9JMD0-1", "protein_name": "BUB3-interacting and GLEBS motif-containing protein ZNF207", "gene_name": "Znf207", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGRKKKKQLKPWCWYCNRDFDDEKILIQHQKAKHFKCHICHKKLYTGPGLAIHCMQVHKETIDAVPNAIPGRTDIELEIYGMEGIPEKDMDERRRLLEQKTQESQKKKQQDDSDEYDDDESAASTSFQPQPVQPQQGYIPPMAQPGLPPVPGAPGMPPGIPPLMPGVPPLMPGMPPVMPGMPPGLHHQRKYTQSFCGENIMMPMGGMMPPGPGIPPLMPGMPPGMPPPVPRPGIPPMTQAQAVSAPGILNRPPAPTAAVPAPQPPVTKPLFPSAGQMGTPVTSSSTASSNSESLSASSKALFPSTAQAQAAVQGPVGTDFKPLNSTPAATTTEPPKPTFPAYTQSTASTTSTTNSTAAKPAASITSKPATLTTTSATSKLIHPDEDISLEERRAQLPKYQRNLPRPGQTPIGNPPVGPIGGMMPPQPGLPQQQAMRPPMPPHGQYGGHHQGMPGYLPGAMPPYGQGPPMVPPYQGGPPRPPMGMRPPVMSQGGRY", "length": 495 }, "evidence": [ { "id": "45918072", "url": "http://www.informatics.jax.org/homology/45918072", "database": "MGI" }, { "id": "O43670", "url": "https://omabrowser.org/oma/group/O43670/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { 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