{ "uniprot_canonical_ac": "O43347-1", "uniprot_ac": "O43347", "uniprot_id": "MSI1H_HUMAN", "mass": { "chemical_mass": 39125.0, "monoisotopic_mass": 39125.0 }, "refseq": { "ac": "NP_002433", "name": "RNA-binding protein Musashi homolog 1 isoform a", "summary": "This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002433" }, "gene_names": [ { "name": "MSI1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O43347", "id": "O43347" }, { "name": "MSI1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002433", "id": "NP_002433" } ], "protein_names": [ { "name": "RNA-binding protein Musashi homolog 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O43347" }, { "name": "Musashi-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43347" }, { "name": "RNA-binding protein Musashi homolog 1 isoform a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002433", "id": "NP_002433" }, { "name": "musashi1; RNA-binding protein Musashi homolog 1; musashi-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002433", "id": "NP_002433" } ], "function": [ { "annotation": "Association between Musashi1 and the development of liver cancer", "evidence": [ { "database": "RefSeq", "id": "NP_002433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002433" }, { "database": "PubMed", "id": "12054577", "url": "https://glygen.org/publication/PubMed/12054577" } ] }, { "annotation": "Dysregulated Stem Cell Markers Musashi-1 and Musashi-2 are Associated with Therapy Resistance in Inflammatory Breast Cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_002433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002433" }, { "database": "PubMed", "id": "37481823", "url": "https://glygen.org/publication/PubMed/37481823" } ] }, { "annotation": "Exosomal Circ_FMN2 Derived from the Serum of Colorectal Cancer Patients Promotes Cancer Progression by miR-338-3p/MSI1 Axis. Erratum:[Appl Biochem Biotechnol. 2023 Sep 27;:. PMID: 37755641]", "evidence": [ { "database": "RefSeq", "id": "NP_002433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002433" }, { "database": "PubMed", "id": "36995659", "url": "https://glygen.org/publication/PubMed/36995659" } ] }, { "annotation": "Increased expression of musashi 1 on breast cancer cells has implication to understand dormancy and survival in bone marrow.", "evidence": [ { "database": "RefSeq", "id": "NP_002433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002433" }, { "database": "PubMed", "id": "36996499", "url": "https://glygen.org/publication/PubMed/36996499" } ] }, { "annotation": "RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O43347", "url": "https://www.uniprot.org/uniprot/O43347#function" } ] }, { "annotation": "Short C-terminal Musashi-1 proteins regulate pluripotency states in embryonic stem cells.", "evidence": [ { "database": "RefSeq", "id": "NP_002433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002433" }, { "database": "PubMed", "id": "37858462", "url": "https://glygen.org/publication/PubMed/37858462" } ] }, { "annotation": "The oncogene Musashi1 encodes novel miRNAs in breast cancer. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_002433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002433" }, { "database": "PubMed", "id": "37607966", "url": "https://glygen.org/publication/PubMed/37607966" } ] }, { "annotation": "This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_002433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002433" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "O43347", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O43347" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 117, "end_pos": 117, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "L", "comment": "Somatic mutation passed 1 out of 6 filters: o-glyco-site-loss (S->L).", "chr_id": "12", "chr_pos": "120363095", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "S117", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { 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"https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs768324684" }, { "id": "rs768324684", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs768324684#frequency_tab" }, { "id": "rs768324684", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs768324684" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 193, "end_pos": 193, "sequence_org": "T", "sequence_mut": "M", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->M).", "chr_id": "12", "chr_pos": "120356976", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T193", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs192219825", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs192219825" }, { "id": "rs192219825", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs192219825" }, { "id": "rs192219825", "database": "ExAC", "url": 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"MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O43347", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43347" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "O43347", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43347" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43347", "url": "https://www.uniprot.org/uniprot/O43347" } ], "common_name": "Human" } ], "gene": [ { "name": "MSI1", "url": "https://www.uniprot.org/uniprot/O43347", "locus": { "chromosome": "12", "start_pos": 120341330, "end_pos": 120369164, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000135097", "url": "https://www.ensembl.org/id/ENSG00000135097" } ] } } ], "crossref": [ { "id": "ENSG00000135097", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000135097", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "O43347", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O43347", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "cd12323", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12323", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12576", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12576", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "MSI1", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=MSI1", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "4440", "url": "https://www.ncbi.nlm.nih.gov/gene/4440", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "7330", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=7330", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "O43347", "url": "https://www.ebi.ac.uk/intact/interactors/id:O43347*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:4440", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:4440", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "603328", "url": "http://www.omim.org/entry/603328", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O43347", "url": "https://www.nextprot.org/entry/NX_O43347", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "O43347", "url": "https://oglcnac.org/atlas/detail/O43347", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "O43347", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43347", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "ADANQAN", "url": "https://omabrowser.org/oma/group/ADANQAN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3127428at2759", "url": "http://www.orthodb.org/?query=3127428at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48032", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48032", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48032:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48032:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "http://pfam.xfam.org/family/PF00076", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O43347", "url": "https://pharos.nih.gov/targets/O43347", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O43347", "url": "http://purl.obolibrary.org/obo/PR_O43347", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-9010553", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9010553", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_002433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002433", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "H0YHB7", "url": "https://www.uniprot.org/uniprot/H0YHB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YHB7-1", "url": "https://www.uniprot.org/uniprot/H0YHB7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O43347", "url": "https://www.uniprot.org/uniprot/O43347", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O43347-1", "url": "https://www.uniprot.org/uniprot/O43347-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METDAPQPGLASPDSPHDPCKMFIGGLSWQTTQEGLREYFGQFGEVKECLVMRDPLTKRSRGFGFVTFMDQAGVDKVLAQSRHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSVNTTVEDVKQYFEQFGKVDDAMLMFDKTTNRHRGFGFVTFESEDIVEKVCEIHFHEINNKMVECKKAQPKEVMSPTGSARGRSRVMPYGMDAFMLGIGMLGYPGFQATTYASRSYTGLAPGYTYQFPEFRVERTPLPSAPVLPELTAIPLTAYGPMAAAAAAAAVVRGTGSHPWTMAPPPGSTPSRTGGFLGTTSPGPMAELYGAANQDSGVSSYISAASPAPSTGFGHSLGGPLIATAFTNGYH", "length": 362, "header": "sp|O43347-1|MSI1H_HUMAN Isoform 1 of RNA-binding protein Musashi homolog 1 OS=Homo sapiens OX=9606 GN=MSI1 PE=1 SV=1 CANONICAL=O43347-1" }, "isoforms": [ { "isoform_ac": "H0YHB7-1", "url": "", "sequence": { "sequence": "XDQAGVDKVLAQSRHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSVNTTVEDVKQYFEQFGKVDDAMLMFDKTTNRHRGFGFVTFESEDIVEKVCEIHFHEINNKMVECKKAQPKEVMSPTGSARGRSRVMPYGMDAFMLGIGMLGYPGFQATTYASRSYTGLAPGYTYQFPAIPLTAYGPMAAAAAAAAVVRGTGSHPWTMAPPPGSTPSRTGGFLGTTSPGPMAELY", "length": 233, "header": "tr|H0YHB7-1|MSI1H_HUMAN Computationally mapped isoform of RNA-binding protein Musashi homolog 1 OS=Homo sapiens OX=9606 GN=MSI1 PE=1 SV=1 CANONICAL=O43347-1" }, "locus": { "chromosome": "12", "start_pos": 120368069, "end_pos": 120346222, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000546985.1", "url": "https://www.ensembl.org/id/ENST00000546985.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000446710.1", "url": "https://www.ensembl.org/id/ENSP00000446710.1" } ] } }, { "isoform_ac": "O43347-1", "url": "", "sequence": { "sequence": "METDAPQPGLASPDSPHDPCKMFIGGLSWQTTQEGLREYFGQFGEVKECLVMRDPLTKRSRGFGFVTFMDQAGVDKVLAQSRHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSVNTTVEDVKQYFEQFGKVDDAMLMFDKTTNRHRGFGFVTFESEDIVEKVCEIHFHEINNKMVECKKAQPKEVMSPTGSARGRSRVMPYGMDAFMLGIGMLGYPGFQATTYASRSYTGLAPGYTYQFPEFRVERTPLPSAPVLPELTAIPLTAYGPMAAAAAAAAVVRGTGSHPWTMAPPPGSTPSRTGGFLGTTSPGPMAELYGAANQDSGVSSYISAASPAPSTGFGHSLGGPLIATAFTNGYH", "length": 362, "header": "sp|O43347-1|MSI1H_HUMAN Isoform 1 of RNA-binding protein Musashi homolog 1 OS=Homo sapiens OX=9606 GN=MSI1 PE=1 SV=1 CANONICAL=O43347-1" }, "locus": { "chromosome": "12", "start_pos": 120369091, "end_pos": 120345594, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000257552.7", "url": "https://www.ensembl.org/id/ENST00000257552.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000257552.2", "url": "https://www.ensembl.org/id/ENSP00000257552.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 117, "start_aa": "Ser", "end_pos": 117, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser117", "evidence": [ { "id": "O43347", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O43347" }, { "id": "34105348", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34105348" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 193, "start_aa": "Thr", "end_pos": 193, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr193", "evidence": [ { "id": "O43347", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43347" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "34105348", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34105348" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 195, "start_aa": "Ser", "end_pos": 195, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser195", "evidence": [ { "id": "O43347", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43347" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "34105348", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34105348" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" } ] } ], "phosphorylation": [ { "start_pos": 12, "end_pos": 12, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O43347", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43347" }, { "database": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" } ], "site_lbl": "Ser12" }, { "start_pos": 191, "end_pos": 191, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O43347", "url": "https://www.uniprot.org/uniprot/O43347" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "iPTMnet", "id": "O43347", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43347" }, { "database": "PubMed", "id": "19664995", "url": "https://glygen.org/publication/PubMed/19664995" } ], "site_lbl": "Ser191" }, { "start_pos": 337, "end_pos": 337, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O43347", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43347" }, { "database": "PubMed", "id": "25888190", "url": "https://glygen.org/publication/PubMed/25888190" } ], "site_lbl": "Ser337" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Musashi: a translational regulator of cell fate.", "journal": "J. Cell Sci.", "date": "2002", "authors": "Okano Hideyuki, Imai Takao, Okabe Masataka", "evidence": [ { "database": "UniProtKB", "id": "O43347", "url": "https://www.uniprot.org/uniprot/O43347" } ], "reference": [ { "type": "PubMed", "id": "11896183", "url": "https://glygen.org/publication/PubMed/11896183" } ] }, { "title": "Expression of the Musashi1 gene encoding the RNA-binding protein in human hepatoma cell lines.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2002", "authors": "Shu HJ, Saito T, Watanabe H, Ito JI, Takeda H, Okano H, Kawata S", "evidence": [ { "database": "UniProtKB", "id": "O43347", "url": "https://www.uniprot.org/uniprot/O43347" }, { "database": "RefSeq", "id": "NP_002433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002433" } ], "reference": [ { "type": "PubMed", "id": "12054577", "url": "https://glygen.org/publication/PubMed/12054577" } ] }, { "title": "The consensus coding sequences of human breast and colorectal cancers.", "journal": "Science (New York, N.Y.)", "date": "2006", "authors": "Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE", "evidence": [ { "database": "UniProtKB", "id": "O43347", "url": "https://www.uniprot.org/uniprot/O43347" } ], "reference": [ { "type": "PubMed", "id": "16959974", "url": "https://glygen.org/publication/PubMed/16959974" } ] }, { "title": "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.", "journal": "Analytical chemistry", "date": "2009", "authors": "Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S", "evidence": [ { "database": "iPTMnet", "id": "O43347", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43347" } ], "reference": [ { "type": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" } ] }, { "title": "Phosphorylation dynamics during early differentiation of human embryonic stem cells.", "journal": "Cell stem cell", "date": "2009", "authors": "Van Hoof D, Munoz J, Braam SR, Pinkse MW, Linding R, Heck AJ, Mummery CL, Krijgsveld J", "evidence": [ { "database": "iPTMnet", "id": "O43347", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43347" } ], "reference": [ { "type": "PubMed", "id": "19664995", "url": "https://glygen.org/publication/PubMed/19664995" } ] }, { "title": "Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2009", "authors": "Yuasa-Kawada J, Kinoshita-Kawada M, Rao Y, Wu JY", "evidence": [ { "database": "Reactome", "id": "R-HSA-9010553", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9010553" } ], "reference": [ { "type": "PubMed", "id": "19706539", "url": "https://glygen.org/publication/PubMed/19706539" } ] }, { "title": "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.", "journal": "Science signaling", "date": "2011", "authors": "Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B", "evidence": [ { "database": "UniProtKB", "id": "O43347", "url": "https://www.uniprot.org/uniprot/O43347" }, { "database": "iPTMnet", "id": "O43347", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43347" } ], "reference": [ { "type": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" } ] }, { "title": "Dystroglycan organizes axon guidance cue localization and axonal pathfinding.", "journal": "Neuron", "date": "2012", "authors": "Wright KM, Lyon KA, Leung H, Leahy DJ, Ma L, Ginty DD", "evidence": [ { "database": "Reactome", "id": "R-HSA-9010553", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9010553" } ], "reference": [ { "type": "PubMed", "id": "23217742", "url": "https://glygen.org/publication/PubMed/23217742" } ] }, { "title": "Regulation of axon guidance by compartmentalized nonsense-mediated mRNA decay.", "journal": "Cell", "date": "2013", "authors": "Colak D, Ji SJ, Porse BT, Jaffrey SR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9010553", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9010553" } ], "reference": [ { "type": "PubMed", "id": "23746841", "url": "https://glygen.org/publication/PubMed/23746841" } ] }, { "title": "USP33 mediates Slit-Robo signaling in inhibiting colorectal cancer cell migration.", "journal": "International journal of cancer", "date": "2015", "authors": "Huang Z, Wen P, Kong R, Cheng H, Zhang B, Quan C, Bian Z, Chen M, Zhang Z, Chen X, Du X, Liu J, Zhu L, Fushimi K, Hua D, Wu JY", "evidence": [ { "database": "Reactome", "id": "R-HSA-9010553", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9010553" } ], "reference": [ { "type": "PubMed", "id": "25242263", "url": "https://glygen.org/publication/PubMed/25242263" } ] }, { "title": "Neural stem and progenitor cell fate transition requires regulation of Musashi1 function.", "journal": "BMC developmental biology", "date": "2015", "authors": "MacNicol AM, Hardy LL, Spencer HJ, MacNicol MC", "evidence": [ { "database": "iPTMnet", "id": "O43347", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43347" } ], "reference": [ { "type": "PubMed", "id": "25888190", "url": "https://glygen.org/publication/PubMed/25888190" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43347", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43347" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "O-GlcNAcylation Quantification of Certain Protein by the Proximity Ligation Assay and Clostridium perfringen OGA(D298N)(CpOGA(D298N)).", "journal": "ACS chemical biology", "date": "2021", "authors": "Song J, Liu C, Wang X, Xu B, Liu X, Li Y, Xia J, Li Y, Zhang C, Li D, Sun H", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43347", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43347" }, { "database": "O-GlcNAc Atlas", "id": "O43347", "url": "https://oglcnac.org/atlas/detail/O43347" } ], "reference": [ { "type": "PubMed", "id": "34105348", "url": "https://glygen.org/publication/PubMed/34105348" } ] }, { "title": "Spatiotemporal Activation of Protein O-GlcNAcylation in Living Cells.", "journal": "Journal of the American Chemical Society", "date": "2022", "authors": "He J, Fan Z, Tian Y, Yang W, Zhou Y, Zhu Q, Zhang W, Qin W, Yi W", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43347", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43347" } ], "reference": [ { "type": "PubMed", "id": "35138101", "url": "https://glygen.org/publication/PubMed/35138101" } ] }, { "title": "Exosomal Circ_FMN2 Derived from the Serum of Colorectal Cancer Patients Promotes Cancer Progression by miR-338-3p/MSI1 Axis.", "journal": "Applied biochemistry and biotechnology", "date": "2023-03-30", "authors": "Yu Qiyao, Zhang Yi, Tian Yanming, Peng Ale, Cui Xiujing, Ding Boyue, Yang Lei, Liu Yabin, Ju Yingchao, Gao Chao", "evidence": [ { "database": "RefSeq", "id": "NP_002433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002433" } ], "reference": [ { "type": "PubMed", "id": "36995659", "url": "https://glygen.org/publication/PubMed/36995659" } ] }, { "title": "Increased expression of musashi 1 on breast cancer cells has implication to understand dormancy and survival in bone marrow.", "journal": "Aging", "date": "2023-03-29", "authors": "Nahas George R, Sherman Lauren S, Sinha Garima, El Far Markos H, Petryna Andrew, Munoz Steven M, Silverio Kimberly A, Shaker Maran, Neopane Pujan, Mariotti Veronica, Rameshwar Pranela", "evidence": [ { "database": "RefSeq", "id": "NP_002433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002433" } ], "reference": [ { "type": "PubMed", "id": "36996499", "url": "https://glygen.org/publication/PubMed/36996499" } ] }, { "title": "Dysregulated Stem Cell Markers Musashi-1 and Musashi-2 are Associated with Therapy Resistance in Inflammatory Breast Cancer.", "journal": "Archives of medical research", "date": "2023-09", "authors": "Haiduk Tiffany S, Sicking Mark, Br\u00fccksken Kathrin A, Espinoza-S\u00e1nchez Nancy A, Eder Kai Moritz, Kemper Bj\u00f6rn, Eich Hans Theodor, G\u00f6tte Martin, Greve Burkhard, Troschel Fabian M", "evidence": [ { "database": "RefSeq", "id": "NP_002433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002433" } ], "reference": [ { "type": "PubMed", "id": "37481823", "url": "https://glygen.org/publication/PubMed/37481823" } ] }, { "title": "The oncogene Musashi1 encodes novel miRNAs in breast cancer.", "journal": "Scientific reports", "date": "2023-08-22", "authors": "Lachinani Liana, Forouzanfar Mahboobeh, Dormiani Kianoush, Soltani Bahram Mohammad, Dolatshahi Kamran, Hakimian Sayyed Mohammadreza, Dokanehiifard Sadat, Nasr-Esfahani Mohammad Hossein", "evidence": [ { "database": "RefSeq", "id": "NP_002433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002433" } ], "reference": [ { "type": "PubMed", "id": "37607966", "url": "https://glygen.org/publication/PubMed/37607966" } ] }, { "title": "Short C-terminal Musashi-1 proteins regulate pluripotency states in embryonic stem cells.", "journal": "Cell reports", "date": "2023-10-31", "authors": "Chen Youwei, Chen Ying, Li Qianyan, Liu Huahua, Han Jiazhen, Zhang Hailin, Cheng Liming, Lin Gufa", "evidence": [ { "database": "RefSeq", "id": "NP_002433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002433" } ], "reference": [ { "type": "PubMed", "id": "37858462", "url": "https://glygen.org/publication/PubMed/37858462" } ] }, { "title": "The human Musashi homolog 1 (MSI1) gene encoding the homologue of Musashi/Nrp-1, a neural RNA-binding protein putatively expressed in CNS stem cells and neural progenitor cells.", "journal": "Genomics", "date": "1998", "authors": "Good P, Yoda A, Sakakibara S, Yamamoto A, Imai T, Sawa H, Ikeuchi T, Tsuji S, Satoh H, Okano H", "evidence": [ { "database": "UniProtKB", "id": "O43347", "url": "https://www.uniprot.org/uniprot/O43347" } ], "reference": [ { "type": "PubMed", "id": "9790759", "url": "https://glygen.org/publication/PubMed/9790759" } ] } ], "pathway": [ { "id": "hsa:4440", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:4440", "resource": "KEGG Pathway" }, { "id": "R-HSA-9010553", "name": "Regulation of expression of SLITs and ROBOs", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9010553", "resource": "Reactome", "description": "Regulation of expression of SLITs and ROBOs" } ], "orthologs": [ { "uniprot_canonical_ac": "Q61474-1", "protein_name": "RNA-binding protein Musashi homolog 1", "gene_name": "Msi1", "tax_id": 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