{ "uniprot_canonical_ac": "O15240-1", "uniprot_ac": "O15240", "uniprot_id": "VGF_HUMAN", "mass": { "chemical_mass": 67258.0, "monoisotopic_mass": 67258.0 }, "refseq": { "ac": "NP_003369", "name": "neurosecretory protein VGF precursor", "summary": "This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003369" }, "gene_names": [ { "name": "VGF", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O15240", "id": "O15240" }, { "name": "SCG7; SgVII", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003369", "id": "NP_003369" }, { "name": "VGF", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003369", "id": "NP_003369" } ], "protein_names": [ { "name": "Neurosecretory protein VGF", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O15240" }, { "name": "neuro-endocrine specific protein VGF; neurosecretory protein VGF", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003369", "id": "NP_003369" }, { "name": "neurosecretory protein VGF precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003369", "id": "NP_003369" } ], "function": [ { "annotation": "Application of neurosecretory protein VGF biomarker model to current diagnostic criteria provides an objective biomarker pattern that identifies patients with amyotrophic lateral sclerosis.", "evidence": [ { "database": "RefSeq", "id": "NP_003369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003369" }, { "database": "PubMed", "id": "16481598", "url": "https://glygen.org/publication/PubMed/16481598" } ] }, { "annotation": "Associations of VGF with Neuropathologies and Cognitive Health in Older Adults.", "evidence": [ { "database": "RefSeq", "id": "NP_003369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003369" }, { "database": "PubMed", "id": "37177846", "url": "https://glygen.org/publication/PubMed/37177846" } ] }, { "annotation": "Changes in VGF and C3aR1 gene expression in human adipose tissue in obesity.", "evidence": [ { "database": "RefSeq", "id": "NP_003369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003369" }, { "database": "PubMed", "id": "33306149", "url": "https://glygen.org/publication/PubMed/33306149" } ] }, { "annotation": "Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris.", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240#function" }, { "database": "PubMed", "id": "23250050", "url": "https://glygen.org/publication/PubMed/23250050" } ] }, { "annotation": "Low VGF is associated with executive dysfunction in patients with major depressive disorder.", "evidence": [ { "database": "RefSeq", "id": "NP_003369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003369" }, { "database": "PubMed", "id": "35738161", "url": "https://glygen.org/publication/PubMed/35738161" } ] }, { "annotation": "Neuronal survival factor VGF promotes chemoresistance and predicts poor prognosis in lung cancers with neuroendocrine feature.", "evidence": [ { "database": "RefSeq", "id": "NP_003369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003369" }, { "database": "PubMed", "id": "35762443", "url": "https://glygen.org/publication/PubMed/35762443" } ] }, { "annotation": "Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons (By similarity). Stimulates also feeding behavior in an orexin-dependent manner in the hypothalamus (By similarity). Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240#function" }, { "database": "UniProtKB", "id": "P20156", "url": "https://www.uniprot.org/uniprot/P20156#function" } ] }, { "annotation": "Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Suppresses presynaptic glutamatergic neurons connected to vasopressin neurons.", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240#function" }, { "database": "UniProtKB", "id": "P20156", "url": "https://www.uniprot.org/uniprot/P20156#function" } ] }, { "annotation": "Plays a role in the regulation of memory formation and depression-related behaviors potentially by influencing synaptic plasticity and neurogenesis. Induces acute and transient activation of the NTRK2/TRKB receptor and subsequent CREB phosphorylation (By similarity). Induces also insulin secretion in insulinoma cells by increasing intracellular calcium mobilization (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240#function" }, { "database": "UniProtKB", "id": "Q0VGU4", "url": "https://www.uniprot.org/uniprot/Q0VGU4#function" } ] }, { "annotation": "Secreted multifunctional neuropeptide that binds to different cell receptors and thereby plays multiple physiological roles including modulation of energy expenditure, pain, response to stress, gastric regulation, glucose homeostasis as well as lipolysis (By similarity). Activates the G-protein-coupled receptor C3AR1 via a folding-upon-binding mechanism leading to enhanced lipolysis in adipocytes (By similarity). Interacts with C1QBP receptor in macrophages and microglia causing increased levels of intracellular calcium and hypersensitivity (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240#function" }, { "database": "UniProtKB", "id": "Q0VGU4", "url": "https://www.uniprot.org/uniprot/Q0VGU4#function" }, { "database": "UniProtKB", "id": "P20156", "url": "https://www.uniprot.org/uniprot/P20156#function" } ] }, { "annotation": "Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240#function" }, { "database": "UniProtKB", "id": "Q0VGU4", "url": "https://www.uniprot.org/uniprot/Q0VGU4#function" }, { "database": "UniProtKB", "id": "P20156", "url": "https://www.uniprot.org/uniprot/P20156#function" } ] }, { "annotation": "Structure of AQEE-30 of VGF Neuropeptide in Membrane-Mimicking Environments. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_003369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003369" }, { "database": "PubMed", "id": "36430431", "url": "https://glygen.org/publication/PubMed/36430431" } ] }, { "annotation": "This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_003369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003369" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs1429835501", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1429835501" }, { "id": "rs1429835501", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1429835501#frequency_tab" }, { "id": "rs1429835501", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1429835501" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 100, "end_pos": 100, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SGS->NGS).", "chr_id": "7", "chr_pos": "101164545", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S100", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs372301855", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs372301855" }, { "id": "rs372301855", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs372301855" }, { "id": "rs372301855", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs372301855" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 147, "end_pos": 147, "sequence_org": "P", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NGP->NGT).", "chr_id": "7", "chr_pos": "101164405", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P147", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs755030999", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs755030999" }, { "id": "rs755030999", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs755030999" }, { "id": "rs755030999", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs755030999#frequency_tab" }, { "id": "rs755030999", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs755030999" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 168, "end_pos": 168, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DFS->NFS).", "chr_id": "7", "chr_pos": "101164342", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D168", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs993099810", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs993099810" }, { "id": "rs993099810", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs993099810" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 189, "end_pos": 189, "sequence_org": "T", "sequence_mut": "K", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->K).", "chr_id": "7", "chr_pos": "101164278", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T189", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs773793143", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs773793143" }, { "id": "rs773793143", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs773793143" }, { "id": "rs773793143", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs773793143#frequency_tab" }, { "id": "rs773793143", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs773793143" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 191, "end_pos": 191, "sequence_org": "T", "sequence_mut": "K", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->K).", "chr_id": "7", "chr_pos": "101164272", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T191", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs773793143", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs773793143" }, { "id": "rs773793143", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs773793143" }, { "id": "rs773793143", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs773793143#frequency_tab" }, { "id": "rs773793143", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs773793143" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 191, "end_pos": 191, "sequence_org": "T", "sequence_mut": "R", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->R).", "chr_id": "7", "chr_pos": "101164272", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T191", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1372565945", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1372565945" }, { "id": "rs1372565945", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1372565945#frequency_tab" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 193, "end_pos": 193, "sequence_org": "T", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->A).", "chr_id": "7", "chr_pos": "101164267", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T193", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1309638202", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1309638202" }, { "id": "rs1309638202", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1309638202" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 252, "end_pos": 252, "sequence_org": "S", "sequence_mut": "F", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->F).", "chr_id": "7", "chr_pos": "101164089", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S252", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs776452487", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs776452487" }, { "id": "rs776452487", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs776452487" }, { "id": "rs776452487", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs776452487" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 256, "end_pos": 256, "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->I).", "chr_id": "7", "chr_pos": "101164077", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T256", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1291973542", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1291973542" }, { "id": "rs1291973542", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1291973542" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 266, "end_pos": 266, "sequence_org": "S", "sequence_mut": "P", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->P).", "chr_id": "7", "chr_pos": "101164048", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S266", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1404460537", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1404460537" }, { "id": "rs1404460537", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1404460537" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 418, "end_pos": 418, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KRS->NRS).", "chr_id": "7", "chr_pos": "101163590", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K418", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1470530107", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1470530107" }, { "id": "rs1470530107", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1470530107#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 487, "end_pos": 487, "sequence_org": "P", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NAP->NAT).", "chr_id": "7", "chr_pos": "101163385", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P487", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1242064020", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1242064020" }, { "id": "rs1242064020", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1242064020" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 53, "end_pos": 53, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DGS->NGS).", "chr_id": "7", "chr_pos": "101164687", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D53", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "64.59", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000128564", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000128564" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "64.01", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000128564", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000128564" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "57.37", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000128564", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000128564" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "78.04", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000128564", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000128564" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "53.92", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000128564", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000128564" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "47.25", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000128564", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000128564" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "77.52", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000128564", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000128564" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "50.35", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000128564", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000128564" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "43.57", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000128564", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000128564" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "75.87", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000128564", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000128564" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "38.74", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000128564", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000128564" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "44.72", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000128564", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000128564" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "39.36", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000128564", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000128564" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O15240", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15240" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15240" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240" } ], "common_name": "Human" } ], "gene": [ { "name": "VGF", "url": "https://www.uniprot.org/uniprot/O15240", "locus": { "chromosome": "7", "start_pos": 101162509, "end_pos": 101165569, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000128564", "url": "https://www.ensembl.org/id/ENSG00000128564" } ] } } ], "crossref": [ { "id": "ENSG00000128564", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000128564", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "VGF", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=VGF", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "7425", "url": "https://www.ncbi.nlm.nih.gov/gene/7425", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "12684", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=12684", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "O15240", "url": "https://www.ebi.ac.uk/intact/interactors/id:O15240*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR026128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:7425", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:7425", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "602186", "url": "http://www.omim.org/entry/602186", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O15240", "url": "https://www.nextprot.org/entry/NX_O15240", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "EMPGHRR", "url": "https://omabrowser.org/oma/group/EMPGHRR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5359558at2759", "url": "http://www.orthodb.org/?query=5359558at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15159", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15159", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15159:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15159:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "7D13", "url": "https://www.rcsb.org/structure/7D13", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7D16", "url": "https://www.rcsb.org/structure/7D16", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8H0G", "url": "https://www.rcsb.org/structure/8H0G", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8H0U", "url": "https://www.rcsb.org/structure/8H0U", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "O15240", 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"url": "DISABLED", "database": "UniCarbKB", "categories": [ "Glycoproteomics" ] }, { "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15240-1", "url": "https://www.uniprot.org/uniprot/O15240-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKALRLSASALFCLLLINGLGAAPPGRPEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEVRGARNSEPQDEGELFQGVDPRALAAVLLQALDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVLPPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQARRAQEEAEAEERRLQEQEELENYIEHVLLRRP", "length": 615, "header": "sp|O15240-1|VGF_HUMAN Isoform 1 of Neurosecretory protein VGF OS=Homo sapiens OX=9606 GN=VGF PE=1 SV=2 CANONICAL=O15240-1" }, "isoforms": [ { "isoform_ac": "O15240-1", "url": "", "sequence": { "sequence": "MKALRLSASALFCLLLINGLGAAPPGRPEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEVRGARNSEPQDEGELFQGVDPRALAAVLLQALDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVLPPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQARRAQEEAEAEERRLQEQEELENYIEHVLLRRP", "length": 615, "header": "sp|O15240-1|VGF_HUMAN Isoform 1 of Neurosecretory protein VGF OS=Homo sapiens OX=9606 GN=VGF PE=1 SV=2 CANONICAL=O15240-1" }, "locus": { "chromosome": "7", "start_pos": 101164843, "end_pos": 101162999, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000249330.3", "url": "https://www.ensembl.org/id/ENST00000249330.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000249330.2", "url": "https://www.ensembl.org/id/ENSP00000249330.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 180, "start_aa": "Thr", "end_pos": 180, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr180", "evidence": [ { "id": "O15240", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "TET", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 185, "start_aa": "Thr", "end_pos": 187, "end_aa": "Thr", "evidence": [ { "id": "O15240", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 187, "start_aa": "Thr", "end_pos": 187, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr187", "evidence": [ { "id": "O15240", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 189, "start_aa": "Thr", "end_pos": 189, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr189", "evidence": [ { "id": "O15240", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 191, "start_aa": "Thr", "end_pos": 191, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr191", "evidence": [ { "id": "O15240", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "TLT", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 191, "start_aa": "Thr", "end_pos": 193, "end_aa": "Thr", "evidence": [ { "id": "O15240", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 193, "start_aa": "Thr", "end_pos": 193, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr193", "evidence": [ { "id": "O15240", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "ASWGEFQAR", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 208, "start_aa": "Ala", "end_pos": 216, "end_aa": "Arg", "evidence": [ { "id": "O15240", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "FGEGVSSPK", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 247, "start_aa": "Phe", "end_pos": 255, "end_aa": "Lys", "evidence": [ { "id": "O15240", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 252, "start_aa": "Ser", "end_pos": 252, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser252", "evidence": [ { "id": "O15240", 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"MKTFTLPASVLFCFLLLIQGLGAAPPGRPDVFPPPLSSEHNGQVAEDAVSRPKDDGVPEVRAARNPEPQDQGELFQGVDPRALASVLLQALDRPASPPSVPGGSQQGTPEEAAEALLTESVRSQTHSLPAPEIQAPAVAPPRPQTQDRDPEEDDRSEELEALASLLQELRDFSPSNAKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPVPSQFQARMSESAPLPETHQFGEGVSSPKTHLGETLTPLSKAYQSLGGPFPKVRRLEGSFLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRDLGGRELQETQQERENEREEEAEQERRGGGEDDVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEEAPGHRRKDAEGAEEGGEEDDDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPARDELPDWNEVLPPWDREEDEVFPPGPYHPFPNYIRPRTLQPPASSRRRHFHHALPPARHHPDLEAQARRAQEEADAEERRLQEQEELENYIEHVLLHRP", "length": 617 }, "evidence": [ { "id": "45927569", "url": "http://www.informatics.jax.org/homology/45927569", "database": "MGI" }, { "id": "O15240", "url": "https://omabrowser.org/oma/group/O15240/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240" } ], "pmid": "" }, { "name": "endoplasmic reticulum lumen", "id": "GO:0005788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240" } ], "pmid": "" }, { "name": "transport vesicle", "id": "GO:0030133", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030133", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 14, "go_terms": [ { "name": "sexual reproduction", "id": "GO:0019953", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019953", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240" } ], "pmid": "" }, { "name": "carbohydrate homeostasis", "id": "GO:0033500", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033500", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240" } ], "pmid": "" }, { "name": "generation of precursor metabolites and energy", "id": "GO:0006091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006091", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240" } ], "pmid": "" }, { "name": "response to cold", "id": "GO:0009409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009409", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240" } ], "pmid": "" }, { "name": "regulation of synaptic plasticity", "id": "GO:0048167", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048167", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240" } ], "pmid": "" }, { "name": "glucose homeostasis", "id": "GO:0042593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042593", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240" } ], "pmid": "" }, { "name": "response to insulin", "id": "GO:0032868", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032868", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240" } ], "pmid": "" }, { "name": "ovarian follicle development", "id": "GO:0001541", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001541", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240" } ], "pmid": "" }, { "name": "defense response to bacterium", "id": "GO:0042742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042742", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240" } ], "pmid": "" }, { "name": "response to cAMP", "id": "GO:0051591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051591", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240" } ], "pmid": "" }, { "name": "response to dietary excess", "id": "GO:0002021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002021", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240" } ], "pmid": "" }, { "name": "regulation of neuronal synaptic plasticity", "id": "GO:0048168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048168", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240" } ], "pmid": "" }, { "name": "insulin secretion", "id": "GO:0030073", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030073", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240" } ], "pmid": "" }, { "name": "synaptic signaling via neuropeptide", "id": "GO:0099538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099538", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "neuropeptide hormone activity", "id": "GO:0005184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005184", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240" } ], "pmid": "" }, { "name": "hormone activity", "id": "GO:0005179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005179", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240" } ], "pmid": "" }, { "name": "growth factor activity", "id": "GO:0008083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008083", "evidence": [ { "database": "UniProtKB", "id": "O15240", "url": "https://www.uniprot.org/uniprot/O15240" } ], "pmid": "" } ] } ] }, "pro_annotation": [ { "name": "neurosecretory protein VGF O-glycosylated 1 (human)", "definition": "A neurosecretory protein VGF (human) that has been O-glycosylated at the residue equivalent to Ser-95 of the amino acid sequence represented by UniProtKB:O15240-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O15240-1, Ser-95, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050723", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050723" } ] } ], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 95, 180, 185, 187, 189, 191, 193, 208, 247, 252, 253, 256, 266, 554 ], "snv_sites": [ 53, 100, 147, 168, 189, 191, 193, 252, 256, 266, 418, 487 ], "glycation_sites": [], "phosphorylation_sites": [ 420, 424 ], "sequon_annotation_sites": [] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 16 }, { "field": "total_sites", "count": 11 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 2 }, { "field": "o_linked_glycan_sites", "count": 11 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 16 }, { "field": "total_sites", "count": 11 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 2 }, { "field": "o_linked_glycan_sites", "count": 11 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 13 }, { "field": "total_sites", "count": 12 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 13 }, { "field": "total_sites", "count": 12 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 197 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }