{
"uniprot_canonical_ac": "O14746-1",
"uniprot_ac": "O14746",
"uniprot_id": "TERT_HUMAN",
"mass": {
"chemical_mass": 126997.0,
"monoisotopic_mass": 126997.0
},
"refseq": {
"ac": "NP_001180305",
"name": "telomerase reverse transcriptase isoform 2",
"summary": "Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008].",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180305"
},
"gene_names": [
{
"name": "TERT",
"resource": "UniProtKB",
"type": "recommended",
"url": "https://www.uniprot.org/uniprot/O14746",
"id": "O14746"
},
{
"name": "CMM9; DKCA2; DKCB4; EST2; hEST2; hTRT; PFBMFT1; TCS1; TP2; TRT",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180305",
"id": "NP_001180305"
},
{
"name": "EST2",
"resource": "UniProtKB",
"type": "synonym",
"url": "https://www.uniprot.org/uniprot/O14746",
"id": "O14746"
},
{
"name": "TCS1",
"resource": "UniProtKB",
"type": "synonym",
"url": "https://www.uniprot.org/uniprot/O14746",
"id": "O14746"
},
{
"name": "TERT",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180305",
"id": "NP_001180305"
},
{
"name": "TRT",
"resource": "UniProtKB",
"type": "synonym",
"url": "https://www.uniprot.org/uniprot/O14746",
"id": "O14746"
},
{
"name": "hCG_1990943",
"resource": "UniProtKB",
"type": "synonym",
"url": "https://www.uniprot.org/uniprot/O14746",
"id": "O14746"
}
],
"protein_names": [
{
"name": "Telomerase reverse transcriptase",
"resource": "UniProtKB",
"type": "recommended",
"url": "",
"id": "O14746"
},
{
"name": "2.7.7.49",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O14746"
},
{
"name": "HEST2",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O14746"
},
{
"name": "TP2",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O14746"
},
{
"name": "Telomerase catalytic subunit",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O14746"
},
{
"name": "Telomerase-associated protein 2",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O14746"
},
{
"name": "telomerase catalytic subunit; telomerase-associated protein 2",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180305",
"id": "NP_001180305"
},
{
"name": "telomerase reverse transcriptase isoform 2",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180305",
"id": "NP_001180305"
}
],
"function": [
{
"annotation": "Association of Ultrasonography Features of Follicular Thyroid Carcinoma With Tumor Invasiveness and Prognosis Based on WHO Classification and TERT Promoter Mutation.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001180305",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180305"
},
{
"database": "PubMed",
"id": "38184773",
"url": "https://glygen.org/publication/PubMed/38184773"
}
]
},
{
"annotation": "Genetic association study of TERT gene variants with chronic kidney disease susceptibility in the Chinese population.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001180305",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180305"
},
{
"database": "PubMed",
"id": "38197421",
"url": "https://glygen.org/publication/PubMed/38197421"
}
]
},
{
"annotation": "Identification of IDH and TERTp mutations using dynamic susceptibility contrast MRI with deep learning in 162 gliomas.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001180305",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180305"
},
{
"database": "PubMed",
"id": "38134710",
"url": "https://glygen.org/publication/PubMed/38134710"
}
]
},
{
"annotation": "Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746#function"
},
{
"database": "PubMed",
"id": "17264120",
"url": "https://glygen.org/publication/PubMed/17264120"
},
{
"database": "PubMed",
"id": "17548608",
"url": "https://glygen.org/publication/PubMed/17548608"
},
{
"database": "PubMed",
"id": "19567472",
"url": "https://glygen.org/publication/PubMed/19567472"
},
{
"database": "PubMed",
"id": "19777057",
"url": "https://glygen.org/publication/PubMed/19777057"
},
{
"database": "PubMed",
"id": "17026956",
"url": "https://glygen.org/publication/PubMed/17026956"
},
{
"database": "PubMed",
"id": "19571879",
"url": "https://glygen.org/publication/PubMed/19571879"
},
{
"database": "PubMed",
"id": "9389643",
"url": "https://glygen.org/publication/PubMed/9389643"
},
{
"database": "PubMed",
"id": "14963003",
"url": "https://glygen.org/publication/PubMed/14963003"
},
{
"database": "PubMed",
"id": "19188162",
"url": "https://glygen.org/publication/PubMed/19188162"
},
{
"database": "PubMed",
"id": "17296728",
"url": "https://glygen.org/publication/PubMed/17296728"
},
{
"database": "PubMed",
"id": "15082768",
"url": "https://glygen.org/publication/PubMed/15082768"
},
{
"database": "PubMed",
"id": "15857955",
"url": "https://glygen.org/publication/PubMed/15857955"
},
{
"database": "UniProtKB",
"id": "A0A590UK92",
"url": "https://www.uniprot.org/uniprot/A0A590UK92#function"
},
{
"database": "UniProtKB",
"id": "RU365061",
"url": "https://www.uniprot.org/uniprot/RU365061#function"
}
]
},
{
"annotation": "Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008].",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001180305",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180305"
}
]
},
{
"annotation": "[Significance of TERT promoter mutation in differential diagnosis of non-invasive inverted urothelial lesions of bladder].",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001180305",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180305"
},
{
"database": "PubMed",
"id": "38058037",
"url": "https://glygen.org/publication/PubMed/38058037"
}
]
}
],
"disease": [
{
"disease_id": "DOID:0070016",
"recommended_name": {
"id": "DOID:0070016",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:0070016",
"name": "autosomal dominant dyskeratosis congenita 2",
"description": "A dyskeratosis congenita that has_material_basis_in an autosomal dominant mutation of the TERT gene on chromosome 5p15.33."
},
"synonyms": [
{
"id": "DOID:0070016",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:0070016",
"name": "DKCA2",
"description": ""
},
{
"id": "MONDO:0013521",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013521",
"name": "dyskeratosis congenita, autosomal dominant 2",
"description": "A dyskeratosis congenita that has material basis in an autosomal dominant mutation of TERT on chromosome 5p15.33."
},
{
"id": "MONDO:0013521",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013521",
"name": "DKCA2",
"description": ""
},
{
"id": "MONDO:0013521",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013521",
"name": "dyskeratosis congenita, autosomal dominant 2",
"description": ""
},
{
"id": "MONDO:0013521",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013521",
"name": "dyskeratosis congenita, autosomal dominant type 2",
"description": ""
},
{
"id": "MONDO:0013521",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013521",
"name": "autosomal dominant dyskeratosis congenita 2",
"description": ""
},
{
"id": "MONDO:0013521",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013521",
"name": "dyskeratosis congenita, autosomal recessive 4",
"description": ""
},
{
"id": "MIM:613989",
"resource": "MIM",
"url": "https://www.omim.org/entry/613989",
"name": "Dyskeratosis congenita, autosomal recessive, 4",
"description": "Dyskeratosis congenita, autosomal recessive, 4"
}
],
"evidence": [
{
"id": "613989",
"database": "MIM",
"url": "https://www.omim.org/entry/613989"
}
]
},
{
"disease_id": "DOID:12449",
"recommended_name": {
"id": "DOID:12449",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:12449",
"name": "aplastic anemia",
"description": "An anemia that is characterized by a deficiency of red blood cells, white blood cells and platelets produced by bone marrow."
},
"synonyms": [
{
"id": "MONDO:0012197",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012197",
"name": "idiopathic aplastic anemia",
"description": "Aplastic anemia without a known cause."
},
{
"id": "MONDO:0012197",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012197",
"name": "idiopathic aplastic aplasia",
"description": ""
},
{
"id": "MONDO:0012197",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012197",
"name": "idiopathic bone marrow failure",
"description": ""
},
{
"id": "MONDO:0012197",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012197",
"name": "anaemia aplastic",
"description": ""
},
{
"id": "MONDO:0012197",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012197",
"name": "anemia aplastic",
"description": ""
},
{
"id": "MONDO:0012197",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012197",
"name": "aplastic Anemia, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012197",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012197",
"name": "aplastic anaemia",
"description": ""
},
{
"id": "MONDO:0012197",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012197",
"name": "aplastic anaemia idiopathic",
"description": ""
},
{
"id": "MONDO:0012197",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012197",
"name": "aplastic anemia",
"description": ""
},
{
"id": "MONDO:0012197",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012197",
"name": "aplastic anemia idiopathic",
"description": ""
},
{
"id": "MONDO:0012197",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012197",
"name": "secondary aplastic anaemia",
"description": ""
},
{
"id": "MONDO:0012197",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012197",
"name": "secondary aplastic anemia",
"description": ""
},
{
"id": "MIM:609135",
"resource": "MIM",
"url": "https://www.omim.org/entry/609135",
"name": "Aplastic anemia",
"description": "Aplastic anemia"
}
],
"evidence": [
{
"id": "609135",
"database": "MIM",
"url": "https://www.omim.org/entry/609135"
}
]
},
{
"disease_id": "MONDO:0013878",
"recommended_name": {
"id": "MONDO:0013878",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013878",
"name": "pulmonary fibrosis and/or bone marrow failure, Telomere-related, 1",
"description": "Any pulmonary fibrosis and/or bone marrow failure, Telomere-related in which the cause of the disease is a mutation in the TERT gene."
},
"synonyms": [
{
"id": "MONDO:0013878",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013878",
"name": "TERT pulmonary fibrosis and/or bone marrow failure, Telomere-related",
"description": ""
},
{
"id": "MONDO:0013878",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013878",
"name": "pulmonary fibrosis and/or bone marrow failure, Telomere-related caused by mutation in TERT",
"description": ""
},
{
"id": "MONDO:0013878",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013878",
"name": "pulmonary fibrosis and/or bone marrow failure, Telomere-related, 1",
"description": ""
},
{
"id": "MONDO:0013878",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013878",
"name": "pulmonary fibrosis and/or bone marrow failure, Telomere-related, type 1",
"description": ""
},
{
"id": "MONDO:0013878",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013878",
"name": "PFBMFT1",
"description": ""
},
{
"id": "MONDO:0013878",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013878",
"name": "pulmonary fibrosis and/or bone marrow failure, TELOMERE-RELATED, 1",
"description": ""
},
{
"id": "MIM:614742",
"resource": "MIM",
"url": "https://www.omim.org/entry/614742",
"name": "Pulmonary fibrosis, and/or bone marrow failure syndrome, telomere-related, 1",
"description": "Pulmonary fibrosis, and/or bone marrow failure syndrome, telomere-related, 1"
}
],
"evidence": [
{
"id": "614742",
"database": "MIM",
"url": "https://www.omim.org/entry/614742"
}
]
},
{
"disease_id": "MONDO:0014056",
"recommended_name": {
"id": "MONDO:0014056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0014056",
"name": "melanoma, cutaneous malignant, susceptibility to, 9",
"description": ""
},
"synonyms": [
{
"id": "MONDO:0014056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0014056",
"name": "melanoma, cutaneous malignant, 9",
"description": ""
},
{
"id": "MONDO:0014056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0014056",
"name": "melanoma, cutaneous malignant, susceptibility to, 9",
"description": ""
},
{
"id": "MONDO:0014056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0014056",
"name": "melanoma, cutaneous malignant, susceptibility to, type 9",
"description": ""
},
{
"id": "MONDO:0014056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0014056",
"name": "CMM9",
"description": ""
},
{
"id": "MONDO:0014056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0014056",
"name": "susceptibility to cutaneous malignant melanoma 9",
"description": ""
},
{
"id": "MIM:615134",
"resource": "MIM",
"url": "https://www.omim.org/entry/615134",
"name": "Melanoma, cutaneous malignant 9",
"description": "Melanoma, cutaneous malignant 9"
}
],
"evidence": [
{
"id": "615134",
"database": "MIM",
"url": "https://www.omim.org/entry/615134"
}
]
}
],
"snv": [],
"mutagenesis": [
{
"start_pos": 137,
"end_pos": 141,
"sequence_org": "WGLLL",
"sequence_mut": "AAAAA",
"comment": "Reduced catalytic activity and repeat addition processivity. Complete loss of catalytic activity but no loss of binding to telomeric primers; when associated with 930-A--A-934.",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
},
{
"database": "PubMed",
"id": "17296728",
"url": "https://glygen.org/publication/PubMed/17296728"
}
]
},
{
"start_pos": 169,
"end_pos": 169,
"sequence_org": "Q",
"sequence_mut": "A",
"comment": "About 80% loss of enzymatic activity. Greatly reduced incorporation of second nucleotide. Altered strength of binding to ssDNA. Little effect on repeat addition processivity, nor on TR interaction nor on protein levels.",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
},
{
"database": "PubMed",
"id": "19777057",
"url": "https://glygen.org/publication/PubMed/19777057"
}
]
},
{
"start_pos": 169,
"end_pos": 169,
"sequence_org": "Q",
"sequence_mut": "N",
"comment": "About 85% loss of enzymatic activity. Greatly reduced incorporation of second nucleotide. Altered strength of binding to ssDNA. No effect on protein levels nor on TR interaction.",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
},
{
"database": "PubMed",
"id": "19777057",
"url": "https://glygen.org/publication/PubMed/19777057"
}
]
},
{
"start_pos": 169,
"end_pos": 169,
"sequence_org": "Q",
"sequence_mut": "T",
"comment": "About 90% loss of enzymatic activity. Greatly reduced incorporation of second nucleotide. Altered strength of binding to ssDNA. No effect on protein levels nor on TR interaction.",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
},
{
"database": "PubMed",
"id": "19777057",
"url": "https://glygen.org/publication/PubMed/19777057"
}
]
},
{
"start_pos": 457,
"end_pos": 457,
"sequence_org": "S",
"sequence_mut": "A",
"comment": "Abolishes phosphorylation by DYRK2.",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
},
{
"database": "PubMed",
"id": "23362280",
"url": "https://glygen.org/publication/PubMed/23362280"
}
]
},
{
"start_pos": 547,
"end_pos": 547,
"sequence_org": "W",
"sequence_mut": "A",
"comment": "Defective in high-affinity TERC interactions.",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
},
{
"database": "PubMed",
"id": "15082768",
"url": "https://glygen.org/publication/PubMed/15082768"
}
]
},
{
"start_pos": 631,
"end_pos": 631,
"sequence_org": "R",
"sequence_mut": "A",
"comment": "Abolishes telomerase catalytic activity.",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
},
{
"database": "PubMed",
"id": "17026956",
"url": "https://glygen.org/publication/PubMed/17026956"
}
]
},
{
"start_pos": 707,
"end_pos": 707,
"sequence_org": "Y",
"sequence_mut": "F",
"comment": "Abolishes oxidative stress-induced phosphorylation and RAN binding. Impaired nuclear export and enhanced antiapoptotic activity against ROS-dependent apoptosis induction. Impaired interaction with PTPN11. No dephosphorylation by PTPN11.",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
},
{
"database": "PubMed",
"id": "12808100",
"url": "https://glygen.org/publication/PubMed/12808100"
},
{
"database": "PubMed",
"id": "18829466",
"url": "https://glygen.org/publication/PubMed/18829466"
}
]
},
{
"start_pos": 712,
"end_pos": 712,
"sequence_org": "D",
"sequence_mut": "A",
"comment": "Loss of telomerase activity. In the absence of TR, no loss of binding to telomeric primers.",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
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},
{
"database": "PubMed",
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{
"database": "PubMed",
"id": "9389643",
"url": "https://glygen.org/publication/PubMed/9389643"
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{
"database": "PubMed",
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},
{
"database": "PubMed",
"id": "17296728",
"url": "https://glygen.org/publication/PubMed/17296728"
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]
},
{
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"end_pos": 866,
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"sequence_mut": "Y",
"comment": "Moderate reduction in telomerase activity, no change in repeat extension rate nor on nucleotide incorporation fidelity. Little further reduction in activity but 13.5-fold increase in nucleotide incorporation fidelity; when associated with M-867.",
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{
"database": "UniProtKB",
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{
"database": "PubMed",
"id": "17264120",
"url": "https://glygen.org/publication/PubMed/17264120"
}
]
},
{
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"end_pos": 867,
"sequence_org": "V",
"sequence_mut": "A",
"comment": "About 75% reduction in telomerase activity, about 80% reduction in repeat reduction rate and 3.9-fold increase in nucleotide incorporation fidelity.",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
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{
"database": "PubMed",
"id": "17264120",
"url": "https://glygen.org/publication/PubMed/17264120"
}
]
},
{
"start_pos": 867,
"end_pos": 867,
"sequence_org": "V",
"sequence_mut": "M",
"comment": "About 75% reduction in telomerase activity, about 50% reduction in repeat extension rate and 5.2-fold increase in nucleotide incorporation fidelity. Little further reduction in activity and 13.5-fold increase in nucleotide incorporation fidelity; when associated with Y-866.",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
},
{
"database": "PubMed",
"id": "17264120",
"url": "https://glygen.org/publication/PubMed/17264120"
}
]
},
{
"start_pos": 867,
"end_pos": 867,
"sequence_org": "V",
"sequence_mut": "T",
"comment": "Severe reduction in telomerase activity, about 50% reduction in repeat extension rate and 2.2-fold increase in nucleotide incorporation fidelity. No further reduction in activity but 2.8-fold increase in nucleotide incorporation fidelity; when associated with Y-866.",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
},
{
"database": "PubMed",
"id": "17264120",
"url": "https://glygen.org/publication/PubMed/17264120"
}
]
},
{
"start_pos": 868,
"end_pos": 868,
"sequence_org": "D",
"sequence_mut": "A",
"comment": "Loss of telomerase activity.",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
},
{
"database": "PubMed",
"id": "17026956",
"url": "https://glygen.org/publication/PubMed/17026956"
},
{
"database": "PubMed",
"id": "9389643",
"url": "https://glygen.org/publication/PubMed/9389643"
},
{
"database": "PubMed",
"id": "9443919",
"url": "https://glygen.org/publication/PubMed/9443919"
},
{
"database": "PubMed",
"id": "15082768",
"url": "https://glygen.org/publication/PubMed/15082768"
},
{
"database": "PubMed",
"id": "15857955",
"url": "https://glygen.org/publication/PubMed/15857955"
}
]
},
{
"start_pos": 868,
"end_pos": 869,
"sequence_org": "DD",
"sequence_mut": "AA",
"comment": "Loss of telomerase activity.",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
]
},
{
"start_pos": 869,
"end_pos": 869,
"sequence_org": "D",
"sequence_mut": "A",
"comment": "Loss of telomerase activity.",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
},
{
"database": "PubMed",
"id": "9389643",
"url": "https://glygen.org/publication/PubMed/9389643"
},
{
"database": "PubMed",
"id": "9443919",
"url": "https://glygen.org/publication/PubMed/9443919"
}
]
},
{
"start_pos": 930,
"end_pos": 934,
"sequence_org": "WCGLL",
"sequence_mut": "AAAAA",
"comment": "Completely abolishes telomerase-mediated primer extension and reduced binding to short telomeric primers. Complete loss of catalytic activity but no further loss of binding to telomeric primers; when associated with 137-A--A-141.",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
},
{
"database": "PubMed",
"id": "17296728",
"url": "https://glygen.org/publication/PubMed/17296728"
}
]
}
],
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{
"tissue": {
"name": "Adult mammalian kidney",
"namespace": "UBERON",
"id": "0000082",
"url": "http://purl.obolibrary.org/obo/UBERON_0000082"
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"score": "48.16",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
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},
{
"tissue": {
"name": "Oral cavity",
"namespace": "UBERON",
"id": "0000167",
"url": "http://purl.obolibrary.org/obo/UBERON_0000167"
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"score": "66.09",
"present": "MEDIUM",
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{
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"url": "https://bgee.org/?page=gene&gene_id=ENSG00000164362"
}
]
},
{
"tissue": {
"name": "Stomach",
"namespace": "UBERON",
"id": "0000945",
"url": "http://purl.obolibrary.org/obo/UBERON_0000945"
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"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000164362",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000164362"
}
]
},
{
"tissue": {
"name": "Uterus",
"namespace": "UBERON",
"id": "0000995",
"url": "http://purl.obolibrary.org/obo/UBERON_0000995"
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"score": "88.79",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
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},
{
"tissue": {
"name": "Esophagus",
"namespace": "UBERON",
"id": "0001043",
"url": "http://purl.obolibrary.org/obo/UBERON_0001043"
},
"score": "17.43",
"present": "LOW",
"evidence": [
{
"database": "Bgee",
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"url": "https://bgee.org/?page=gene&gene_id=ENSG00000164362"
}
]
},
{
"tissue": {
"name": "Rectum",
"namespace": "UBERON",
"id": "0001052",
"url": "http://purl.obolibrary.org/obo/UBERON_0001052"
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"score": "53.46",
"present": "MEDIUM",
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{
"database": "Bgee",
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"url": "https://bgee.org/?page=gene&gene_id=ENSG00000164362"
}
]
},
{
"tissue": {
"name": "Colon",
"namespace": "UBERON",
"id": "0001155",
"url": "http://purl.obolibrary.org/obo/UBERON_0001155"
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"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000164362",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000164362"
}
]
},
{
"tissue": {
"name": "Urinary bladder",
"namespace": "UBERON",
"id": "0001255",
"url": "http://purl.obolibrary.org/obo/UBERON_0001255"
},
"score": "41.57",
"present": "LOW",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000164362",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000164362"
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]
},
{
"tissue": {
"name": "Thyroid gland",
"namespace": "UBERON",
"id": "0002046",
"url": "http://purl.obolibrary.org/obo/UBERON_0002046"
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"present": "LOW",
"evidence": [
{
"database": "Bgee",
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"url": "https://bgee.org/?page=gene&gene_id=ENSG00000164362"
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]
},
{
"tissue": {
"name": "Lung",
"namespace": "UBERON",
"id": "0002048",
"url": "http://purl.obolibrary.org/obo/UBERON_0002048"
},
"score": "70.95",
"present": "MEDIUM",
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{
"database": "Bgee",
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"url": "https://bgee.org/?page=gene&gene_id=ENSG00000164362"
}
]
},
{
"tissue": {
"name": "Liver",
"namespace": "UBERON",
"id": "0002107",
"url": "http://purl.obolibrary.org/obo/UBERON_0002107"
},
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"present": "LOW",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000164362",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000164362"
}
]
},
{
"tissue": {
"name": "Prostate gland",
"namespace": "UBERON",
"id": "0002367",
"url": "http://purl.obolibrary.org/obo/UBERON_0002367"
},
"score": "35.09",
"present": "LOW",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000164362",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000164362"
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]
},
{
"tissue": {
"name": "Thoracic mammary gland",
"namespace": "UBERON",
"id": "0005200",
"url": "http://purl.obolibrary.org/obo/UBERON_0005200"
},
"score": "38.78",
"present": "LOW",
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{
"database": "Bgee",
"id": "ENSG00000164362",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000164362"
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],
"expression_disease": [
{
"significant": "Yes",
"trend": "up",
"name": "Prostate cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10283",
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{
"database": "BioXpress",
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{
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{
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},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
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"name": "malignant tumor of the prostate",
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},
{
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"name": "prostate cancer, familial",
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},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
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},
{
"id": "DOID:10283",
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"name": "prostatic cancer",
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},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
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},
{
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"url": "http://disease-ontology.org/term/DOID:10283",
"name": "tumor of the prostate",
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},
{
"id": "MONDO:0012597",
"resource": "MONDO",
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},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, type 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "HPC9",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "EHBP1 familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "familial prostate cancer caused by mutation in EHBP1",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, type 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "HPC12",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, type 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "HPC5",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, type 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, susceptibility to, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "HPC3",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, type 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, susceptibility to, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "HPC4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, on chromosome 7",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "MSMB familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "familial prostate cancer caused by mutation in MSMB",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, type 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "HPC13",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, type 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "HPC8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "predisposing for prostate cancer",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, type 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "HPC6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "HPC10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate carcinoma",
"description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate carcinoma",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, somatic",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, hereditary",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "HPC7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer aggressiveness",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "RNASEL familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "familial prostate cancer caused by mutation in RNASEL",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, type 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "HPC1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "Prca1",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "HPC11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "HPC14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "HPC15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "HPCX1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer susceptibility, X-linked",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "HPCX2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MIM:611868",
"resource": "MIM",
"url": "https://www.omim.org/entry/611868",
"name": "Prostate cancer, hereditary, 12",
"description": "Prostate cancer, hereditary, 12"
},
{
"id": "MIM:611928",
"resource": "MIM",
"url": "https://www.omim.org/entry/611928",
"name": "Prostate cancer, hereditary, 13",
"description": "Prostate cancer, hereditary, 13"
},
{
"id": "MIM:176807",
"resource": "MIM",
"url": "https://www.omim.org/entry/176807",
"name": "Prostate cancer",
"description": "Prostate cancer"
},
{
"id": "MIM:601518",
"resource": "MIM",
"url": "https://www.omim.org/entry/601518",
"name": "Prostate cancer, hereditary, 1",
"description": "Prostate cancer, hereditary, 1"
},
{
"id": "MIM:611955",
"resource": "MIM",
"url": "https://www.omim.org/entry/611955",
"name": "Prostate cancer, hereditary, 11",
"description": "Prostate cancer, hereditary, 11"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Stomach cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10534",
"evidence": [
{
"database": "BioXpress",
"id": "O14746",
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}
],
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{
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},
"synonyms": [
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},
{
"id": "DOID:10534",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca lesser curvature - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "cancer of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer risk after h. pylori infection",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumor",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumour",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant stomach neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "stomach cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca body - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "ca greater curvature of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, intestinal",
"description": ""
},
{
"id": "MIM:613659",
"resource": "MIM",
"url": "https://www.omim.org/entry/613659",
"name": "Gastric cancer",
"description": "Gastric cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Urinary bladder cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11054",
"evidence": [
{
"database": "BioXpress",
"id": "O14746",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14746"
}
],
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{
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},
"synonyms": [
{
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},
{
"id": "DOID:11054",
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"url": "http://disease-ontology.org/term/DOID:11054",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": "A primary or metastatic malignant neoplasm involving the bladder."
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "bladder cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "cancer of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumour",
"description": ""
},
{
"id": "MIM:109800",
"resource": "MIM",
"url": "https://www.omim.org/entry/109800",
"name": "Bladder cancer",
"description": "Bladder cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Head and neck cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11934",
"evidence": [
{
"database": "BioXpress",
"id": "O14746",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14746"
}
],
"disease": [
{
"disease_id": "DOID:11934",
"recommended_name": {
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck cancer",
"description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
},
"synonyms": [
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck tumours",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head/neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "tumor of head and neck",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Lung cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1324",
"evidence": [
{
"database": "BioXpress",
"id": "O14746",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14746"
}
],
"disease": [
{
"disease_id": "DOID:1324",
"recommended_name": {
"id": "DOID:1324",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1324",
"name": "lung cancer",
"description": "A respiratory system cancer that is located_in the lung."
},
"synonyms": [
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "LNCR1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "LNCR3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "adenocarcinoma of lung, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "LNCR4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "LNCR5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": "A malignant neoplasm involving the lung."
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "cancer of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung neoplasm",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumor",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumour",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung neoplasm",
"description": ""
},
{
"id": "MIM:211980",
"resource": "MIM",
"url": "https://www.omim.org/entry/211980",
"name": "Lung cancer",
"description": "Lung cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Breast cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1612",
"evidence": [
{
"database": "BioXpress",
"id": "O14746",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14746"
}
],
"disease": [
{
"disease_id": "DOID:1612",
"recommended_name": {
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast cancer",
"description": "A thoracic cancer that originates in the mammary gland."
},
"synonyms": [
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant neoplasm of breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant tumor of the breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary cancer",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "primary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, lobular, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of the breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial Male",
"description": ""
},
{
"id": "MIM:114480",
"resource": "MIM",
"url": "https://www.omim.org/entry/114480",
"name": "Breast cancer",
"description": "Breast cancer"
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Thyroid cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1781",
"evidence": [
{
"database": "BioXpress",
"id": "O14746",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14746"
}
],
"disease": [
{
"disease_id": "DOID:1781",
"recommended_name": {
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid cancer",
"description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
},
"synonyms": [
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid gland cancer",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "Thyroid gland neoplasm",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant tumour of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Kidney cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:263",
"evidence": [
{
"database": "BioXpress",
"id": "O14746",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14746"
}
],
"disease": [
{
"disease_id": "DOID:263",
"recommended_name": {
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "kidney cancer",
"description": "A urinary system cancer that is located_in the kidney."
},
"synonyms": [
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant neoplasm of kidney except pelvis",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant tumour of kidney",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "renal cancer",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Liver cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:3571",
"evidence": [
{
"database": "BioXpress",
"id": "O14746",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14746"
}
],
"disease": [
{
"disease_id": "DOID:3571",
"recommended_name": {
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "liver cancer",
"description": "A hepatobiliary system cancer that is located_in the liver."
},
"synonyms": [
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Ca liver - primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Resectable malignant neoplasm of Liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant hepato-biliary neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant tumor of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "non-resectable primary hepatic malignant neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary liver cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "resectable malignant neoplasm of the liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, not specified as primary or secondary",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Uterine cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:363",
"evidence": [
{
"database": "BioXpress",
"id": "O14746",
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{
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{
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{
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},
{
"id": "MONDO:0005575",
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},
{
"id": "MONDO:0005575",
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},
{
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},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
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},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
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"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
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},
{
"id": "MIM:114500",
"resource": "MIM",
"url": "https://www.omim.org/entry/114500",
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"description": "Colorectal cancer"
}
]
}
]
}
],
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"name": "Homo sapiens",
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"evidence": [
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}
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"id": "cd01648",
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{
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{
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{
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{
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{
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},
{
"id": "LAAMKFH",
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]
},
{
"id": "55913at2759",
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]
},
{
"id": "PTHR12066",
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},
{
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},
{
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{
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{
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{
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},
{
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{
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{
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{
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]
},
{
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]
},
{
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},
{
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},
{
"id": "7QXS",
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]
},
{
"id": "7TRD",
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]
},
{
"id": "7TRE",
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]
},
{
"id": "7TRF",
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]
},
{
"id": "7V99",
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]
},
{
"id": "PF00078",
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]
},
{
"id": "PF12009",
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]
},
{
"id": "PF21399",
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]
},
{
"id": "O14746",
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]
},
{
"id": "PR_O14746",
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"database": "PRO",
"categories": [
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]
},
{
"id": "R-HSA-171319",
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]
},
{
"id": "R-HSA-174430",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174430",
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]
},
{
"id": "R-HSA-201722",
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]
},
{
"id": "NP_001180305",
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]
},
{
"id": "22508",
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]
},
{
"id": "A0A590UK92",
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]
},
{
"id": "A0A590UK92-1",
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]
},
{
"id": "O14746",
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]
},
{
"id": "O14746-1",
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]
},
{
"id": "O14746-2",
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]
},
{
"id": "O14746-3",
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]
},
{
"id": "O14746-4",
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"categories": [
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]
}
],
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"length": 1132,
"header": "sp|O14746-1|TERT_HUMAN Isoform 1 of Telomerase reverse transcriptase OS=Homo sapiens OX=9606 GN=TERT PE=1 SV=1 CANONICAL=O14746-1"
},
"isoforms": [
{
"isoform_ac": "A0A590UK92-1",
"url": "",
"sequence": {
"sequence": "MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPWDARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVRSYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGAATQARPPPHASGPRRRLGCERAWNHSVREAGVPLGLPAPGARRRGGSASRSLPLPKRPRRGAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVGRQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSLRPSLTGARRLVETIFLGSRPWMPGTPRRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVTPAAGVCAREKPQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGSRHNERRFLRNTKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSPGEEVVAVEGPGPRAECSRGSEKGAGRALVLLSPSSRGHTWLFAQDVEWTR",
"length": 574,
"header": "tr|A0A590UK92-1|A0A590UK92_HUMAN Computationally mapped isoform of Telomerase reverse transcriptase OS=Homo sapiens OX=9606 GN=TERT PE=1 SV=1 CANONICAL=O14746-1"
},
"locus": {
"chromosome": "5",
"start_pos": 1294989,
"end_pos": 1293164,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000656021.1",
"url": "https://www.ensembl.org/id/ENST00000656021.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000499759.1",
"url": "https://www.ensembl.org/id/ENSP00000499759.1"
}
]
}
},
{
"isoform_ac": "O14746-1",
"url": "",
"sequence": {
"sequence": "MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPWDARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVRSYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGAATQARPPPHASGPRRRLGCERAWNHSVREAGVPLGLPAPGARRRGGSASRSLPLPKRPRRGAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVGRQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSLRPSLTGARRLVETIFLGSRPWMPGTPRRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVTPAAGVCAREKPQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGSRHNERRFLRNTKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSPGVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHLQETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNLRKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTFNRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTILD",
"length": 1132,
"header": "sp|O14746-1|TERT_HUMAN Isoform 1 of Telomerase reverse transcriptase OS=Homo sapiens OX=9606 GN=TERT PE=1 SV=1 CANONICAL=O14746-1"
},
"locus": {
"chromosome": "5",
"start_pos": 1294989,
"end_pos": 1253731,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000310581.10",
"url": "https://www.ensembl.org/id/ENST00000310581.10"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000309572.5",
"url": "https://www.ensembl.org/id/ENSP00000309572.5"
}
]
}
},
{
"isoform_ac": "O14746-2",
"url": "",
"sequence": {
"sequence": "MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPWDARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVRSYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGAATQARPPPHASGPRRRLGCERAWNHSVREAGVPLGLPAPGARRRGGSASRSLPLPKRPRRGAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVGRQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSLRPSLTGARRLVETIFLGSRPWMPGTPRRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVTPAAGVCAREKPQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGSRHNERRFLRNTKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSPGVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVLRPVPGDPAGLHPLHAALQPVLRRHGEQAVCGDSAGRAAPAFGG",
"length": 807,
"header": "sp|O14746-2|TERT_HUMAN Isoform 2 of Telomerase reverse transcriptase OS=Homo sapiens OX=9606 GN=TERT PE=1 SV=1 CANONICAL=O14746-1"
},
"locus": {}
},
{
"isoform_ac": "O14746-3",
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"length": 1125
},
"evidence": [
{
"id": "45922012",
"url": "http://www.informatics.jax.org/homology/45922012",
"database": "MGI"
},
{
"id": "O14746",
"url": "https://omabrowser.org/oma/group/O14746/",
"database": "OMA"
}
],
"common_name": "Rat"
}
],
"go_annotation": {
"categories": [
{
"name": "Biological Process",
"total": 32,
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{
"name": "RNA-templated DNA biosynthetic process",
"id": "GO:0006278",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006278",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "DNA biosynthetic process",
"id": "GO:0071897",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071897",
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{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "positive regulation of stem cell proliferation",
"id": "GO:2000648",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000648",
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{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "negative regulation of gene expression",
"id": "GO:0010629",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "positive regulation of protein binding",
"id": "GO:0032092",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032092",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "positive regulation of angiogenesis",
"id": "GO:0045766",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045766",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "negative regulation of neuron apoptotic process",
"id": "GO:0043524",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043524",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "cellular response to hypoxia",
"id": "GO:0071456",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071456",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "telomere maintenance",
"id": "GO:0000723",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000723",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "response to cadmium ion",
"id": "GO:0046686",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046686",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "establishment of protein localization to telomere",
"id": "GO:0070200",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070200",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "regulation of protein stability",
"id": "GO:0031647",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031647",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "positive regulation of nitric-oxide synthase activity",
"id": "GO:0051000",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051000",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "positive regulation of vascular associated smooth muscle cell proliferation",
"id": "GO:1904707",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904707",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "negative regulation of endothelial cell apoptotic process",
"id": "GO:2000352",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000352",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "negative regulation of cellular senescence",
"id": "GO:2000773",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000773",
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{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "positive regulation of G1/S transition of mitotic cell cycle",
"id": "GO:1900087",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900087",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "mitochondrion organization",
"id": "GO:0007005",
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"id": "O14746",
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}
],
"pmid": ""
},
{
"name": "positive regulation of glucose import",
"id": "GO:0046326",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046326",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "siRNA processing",
"id": "GO:0030422",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030422",
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"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "negative regulation of extrinsic apoptotic signaling pathway in absence of ligand",
"id": "GO:2001240",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001240",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "positive regulation of vascular associated smooth muscle cell migration",
"id": "GO:1904754",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904754",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
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}
],
"pmid": ""
},
{
"name": "replicative senescence",
"id": "GO:0090399",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090399",
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"url": "https://www.uniprot.org/uniprot/O14746"
}
],
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},
{
"name": "positive regulation of Wnt signaling pathway",
"id": "GO:0030177",
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{
"database": "UniProtKB",
"id": "O14746",
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}
],
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},
{
"name": "positive regulation of miRNA transcription",
"id": "GO:1902895",
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{
"database": "UniProtKB",
"id": "O14746",
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}
],
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},
{
"name": "telomere maintenance via telomerase",
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}
],
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},
{
"name": "positive regulation of protein localization to nucleolus",
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"database": "UniProtKB",
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}
],
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},
{
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}
],
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},
{
"name": "DNA strand elongation",
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"id": "O14746",
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}
],
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},
{
"name": "positive regulation of hair cycle",
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}
],
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},
{
"name": "positive regulation of transdifferentiation",
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{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
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},
{
"name": "siRNA transcription",
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"url": "https://www.uniprot.org/uniprot/O14746"
}
],
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}
]
},
{
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"name": "RNA-directed DNA polymerase activity",
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}
],
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},
{
"name": "RNA-dependent RNA polymerase activity",
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}
],
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},
{
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}
],
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},
{
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}
],
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},
{
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"url": "https://www.uniprot.org/uniprot/O14746"
}
],
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},
{
"name": "protein homodimerization activity",
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{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
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},
{
"name": "metal ion binding",
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"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
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{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "protein-folding chaperone binding",
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"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051087",
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{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
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},
{
"name": "telomeric DNA binding",
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{
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"id": "O14746",
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}
],
"pmid": ""
},
{
"name": "tRNA binding",
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"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
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},
{
"name": "transcription coactivator binding",
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"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
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},
{
"name": "telomerase activity",
"id": "GO:0003720",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003720",
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"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "template-free RNA nucleotidyltransferase",
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"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098680",
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"database": "UniProtKB",
"id": "O14746",
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}
],
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},
{
"name": "telomerase RNA binding",
"id": "GO:0070034",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070034",
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"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "telomerase RNA reverse transcriptase activity",
"id": "GO:0003721",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003721",
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"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
}
]
},
{
"name": "Cellular Component",
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{
"name": "nucleus",
"id": "GO:0005634",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
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{
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"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "nucleoplasm",
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"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
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"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "nucleolus",
"id": "GO:0005730",
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}
],
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},
{
"name": "cytosol",
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}
],
"pmid": ""
},
{
"name": "plasma membrane",
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"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
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"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "nuclear speck",
"id": "GO:0016607",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607",
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"id": "O14746",
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}
],
"pmid": ""
},
{
"name": "mitochondrial nucleoid",
"id": "GO:0042645",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042645",
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{
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"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "nuclear telomere cap complex",
"id": "GO:0000783",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000783",
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{
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"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "PML body",
"id": "GO:0016605",
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"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "telomerase holoenzyme complex",
"id": "GO:0005697",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005697",
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"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "chromosome, telomeric region",
"id": "GO:0000781",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000781",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "telomerase catalytic core complex",
"id": "GO:0000333",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000333",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "RNA-directed RNA polymerase complex",
"id": "GO:0031379",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031379",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "TERT-RMRP complex",
"id": "GO:1990572",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990572",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
},
{
"name": "cytoplasm",
"id": "GO:0005737",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
}
],
"pmid": ""
}
]
}
]
},
"pro_annotation": [],
"site_annotation": [
{
"start_pos": 204,
"end_pos": 206,
"annotation": "n_glycosylation_sequon"
}
],
"ptm_annotation": [
{
"annotation": "(Microbial infection) In case of infection by HIV-1, the EDVP complex is hijacked by HIV-1 via interaction between HIV-1 Vpr and DCAF1/VPRBP, leading to ubiquitination and degradation.",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
},
{
"database": "PubMed",
"id": "23362280",
"url": "https://glygen.org/publication/PubMed/23362280"
}
]
},
{
"annotation": "Phosphorylation at Tyr-707 under oxidative stress leads to translocation of TERT to the cytoplasm and reduces its antiapoptotic activity. Dephosphorylated by SHP2/PTPN11 leading to nuclear retention. Phosphorylation at Ser-227 by the AKT pathway promotes nuclear location. Phosphorylation at the G2/M phase at Ser-457 by DYRK2 promotes ubiquitination by the EDVP complex and degradation.",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
},
{
"database": "PubMed",
"id": "22366458",
"url": "https://glygen.org/publication/PubMed/22366458"
},
{
"database": "PubMed",
"id": "12808100",
"url": "https://glygen.org/publication/PubMed/12808100"
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{
"database": "PubMed",
"id": "23362280",
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},
{
"database": "PubMed",
"id": "18829466",
"url": "https://glygen.org/publication/PubMed/18829466"
}
]
},
{
"annotation": "Ubiquitinated by the EDVP complex, a E3 ligase complex following phosphorylation at Ser-457 by DYRK2. Ubiquitinated leads to proteasomal degradation.",
"evidence": [
{
"database": "UniProtKB",
"id": "O14746",
"url": "https://www.uniprot.org/uniprot/O14746"
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{
"database": "PubMed",
"id": "23362280",
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}
]
}
],
"interactions": [],
"reactions": [
{
"id": "22508",
"name": "",
"equation": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
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"evidence": [
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"id": "22508",
"database": "Rhea",
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}
]
},
{
"id": "R-HSA-163090",
"name": "Elongation Of The Telomeric Chromosome End",
"equation": "",
"summary": "The template of hTERC directs the sequential addition of nucleotides to the 3' telomeric DNA end. Following addition of a nucleotide, the template and catalytic site must move relative to one another within the telomerase RNP to place the appropriate template residue in the active site. As base-pairing and nucleotide addition occur at one end of the template, base pair melting occurs at the other (Collins and Greider 1993; Wang and Blackburn, 1997; Hammond and Cech 1998; Benjamin et al. 2000; Forstemann and Lingner 2005). This un-pairing is thought to reduce the energy used for mediating the subsequent translocation step. Nucleotide addition can occur up until the template boundary which in hTERC is defined by a helix called P1b (Chen and Greider 2003).
",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q9NZ71-1",
"O60832-1",
"O14746-1"
],
"evidence": [
{
"id": "R-HSA-163090",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-163090"
}
]
},
{
"id": "R-HSA-163096",
"name": "Recruitment of Telomerase RNP to the Telomeric Chromosome End",
"equation": "",
"summary": "Studies in yeast and human cells indicate that recruitment of telomerase to a telomere may be influenced by multiple variables, including regulatory protein factors, hTERT domains, telomere length, and the cell cycle stage. First, in yeast, the telomerase associated factor Est1 and the single-strand DNA binding protein Cdc13 play roles in telomerase recruitment (Pennock et al. 2001; Bianchi et al. 2004). Analogous proteins exist in human cells (Est1A, Est1B, Est1C, and POT1, respectively); however, how or whether these proteins are directly involved in telomerase recruitment remains to be elucidated. Second, N-terminal residues of hTERT within the DAT (dissociate the activities of telomerase) domain may have a role in binding single stranded telomeric DNA as the \\anchor site\\ (Lee et al. 1993; Moriarty et al. 2005). Third, a cis-acting mechanism in yeast and humans that regulates telomere length maintenance may modulate telomerase access to the telomere (reviewed in Blackburn 2001; Smogorzewska and de Lange, 2004). Long telomeres, which have more associated protein factors, are in a state that is acted on by telomerase less frequently than that of short telomeres, which have fewer associated factors. Whether short telomeres actively recruit telomerase remains to be determined. Last, the recruitment of telomerase to telomeres shows cell-cycle regulation (Taggart et al. 2002; Smith et al. 2003; Fisher et al. 2004; Jady et al. 2006; Tomlinson et al. 2006). Presence of the telomeric protection complex shelterin at telomeres is necessary for the recruitment of telomerase. ACD (TPP1), the subunit of the shelterin complex, directly interacts, through its TEL patch region, with telomerase and is required for telomerase function in vivo (Abreu et al. 2010, Nandakumar et al. 2012, Sexton et al. 2014). The interaction involves the TEN domain of TERT (Schmidt et al. 2014).
The helicase RTEL1 is recruited to telomeres in S phase via direct interaction with the shelterin complex subunit TREF2. RTEL1 is needed for T-loop unwinding and resolution of telomeric G-quadruplex (G4) DNA structures, necessary steps for efficient telomere replication (Vannier et al. 2012, Sarek et al. 2015). Germline mutations in RTEL1 cause a severe form of dyskeratosis congenita, a telomere disorder syndrome, called Hoyeraal Hreidarsson syndrome (Ballew, Yeager et al. 2013; Walne et al. 2013; Ballew, Joseph et al. 2013, Le Guen et al. 2013, Deng et al. 2013). Loading of RTEL1 to telomere ends is negatively regulated outside of S phase by CDK2:CCNA-mediated phosphorylation of the shelterin complex subunit TERF2 at serine residue S365. At the S phase entry, TERF2 is dephosphorylated by the PP6 phosphatase, thus allowing timely RTEL1 loading (Sarek et al. 2019).",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q9NZ71-1",
"O00743-1",
"O60832-1",
"P24941-1",
"O14746-1"
],
"evidence": [
{
"id": "R-HSA-163096",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-163096"
}
]
},
{
"id": "R-HSA-163099",
"name": "Alignment Of The RNA Template On The Telomeric Chromosome End",
"equation": "",
"summary": "In vitro studies of telomerase complexes derived from multiple organisms indicate that at least two types of interactions are important for telomerase RNP catalytic site alignment at the 3' G-rich single-strand telomere end. In one interaction, an alignment region in hTERC base-pairs with the 3' G-rich single-strand telomeric DNA end to form an RNA-DNA hybrid, which positions the template adjacent to the 3' end of the telomere. In a second interaction, a portion of hTERT is proposed to interact with the DNA 5' of the telomerase RNA/DNA primer hybrid (Harrington and Greider 1991; Morin 1991; Moriarty et al. 2005), which is important for the catalytic rate (Lee and Blackburn, 1993) and presumably allows telomerase to maintain contact with the chromosome during the translocation step. How the anchor site binding and template hybridization are coordinated is not known.",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q9NZ71-1",
"O60832-1",
"O14746-1"
],
"evidence": [
{
"id": "R-HSA-163099",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-163099"
}
]
},
{
"id": "R-HSA-163120",
"name": "Disassociation of Telomerase RNP and the Chromosome End",
"equation": "",
"summary": "In vitro, telomerase can disassociate from the primer following addition of each nucleotide or during the translocation step. The regulation of telomerase disassociation from the telomere in vivo is not well-characterized (de Lange 2002, Zhu et al. 2003, Ye et al. 2004, Smorgozewska and de Lange 2004, Tomita 2018). One factor that may be involved is a helicase termed hPIF1, which can unanneal the telomerase RNA/telomeric DNA hybrid (Boule et al. 2005; Zhang et al. 2006). PIF1 can directly interact with telomerase (Mateyak and Zakian 2006) and it acts to inhibit telomerase activity and telomere lengthening (Zhang et al. 2006, Paeschke et al. 2013).
In addition to regulation of telomere lengthening, PIF1 is also involved in resolution of G-quadruplex (G4) structures in single-stranded nucleic acid intermediates that form during DNA replication and gene expression (Sanders 2010, Paeschke et al. 2013).",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [
"R-ALL-9668967",
"R-HSA-5686112"
],
"enzyme_list": [
"Q9NZ71-1",
"Q9H611-1",
"O60832-1",
"O14746-1"
],
"evidence": [
{
"id": "R-HSA-163120",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-163120"
}
]
},
{
"id": "R-HSA-164616",
"name": "Biogenesis and assembly of the telomerase RNP",
"equation": "",
"summary": "hTERC is transcribed as a precursor and is processed at its 3' end to yield a 451 nucleotide RNA (Zaug et al. 1996). The accumulation of hTERC that has undergone this processing event requires a conserved region of sequence termed the box H/ACA motif (Mitchell et al. 1999a). This motif is bound by a complex containing DKC1 (dyskerin), and mutations in dyskerin affect the processing and accumulation of hTERC (Mitchell et al. 1999b; Mitchell and Collins 2000; Fu and Collins 2003). Studies of purified, catalytically active telomerase indicate that the minimal structure that has telomerase activity in vitro is a complex of one molecule of hTERC RNA, one molecule of hTERT and two molecules of DKC1 (dyskerin) (Cohen et al. 2007). A cryo-electron microscopy (EM) structure of human substrate-bound telomerase holoenzyme revealed that, in addition to one molecule of hTERC RNA, one molecule of hTERT and two molecules of DKC1, the holoenzyme also contains one molecule of WRAP53 (TCAB1, also known as telomere Cajal body protein 1) and two molecules of each NOP10, NHP2 (NOLA2) and GAR1 (Nguyen et al. 2018). WRAP53 is needed for the activity and localization of the telomerase holoenzyme to Cajal bodies (Venteicher et al. 2009). Homozygosity for NHP2 mutations is associated with telomerase failure (dyskeratosis congenita) in humans (Vuillamy et al. 2008). Several additional proteins may associate with the holoenzyme, promoting its assembly and modulating its activity. RUVBL1 (pontin) and RUVBL2 (reptin) are found associated with human telomerase RNPs purified from HeLa cells, and activities of these proteins are required for telomerase RNP assembly in vivo (Venteicher et al. 2008). Pontin and reptin may modulate the interaction between SHQ1 and DKC1 (Machado-Pinilla et al. 2012), but as their exact roles in the assembly and function of telomerase RNP remain unclear, they are annotated simply as positive regulators of telomerase RNP formation.
The core components hTERC and hTERT undergo trafficking in the cell that may be important for telomerase function. hTERC has been found localized in multiple nuclear structures, including Cajal bodies, nucleoli, and at telomeres (Mitchell et al. 1999a; Jady et al. 2004; Zhu et al. 2004; Jady et al. 2006; Tomlinson et al. 2006). hTERT is also reported localize in Cajal bodies, nucleoli, and to associate with telomeres (Etheridge et al. 2002; Wong et al. 2002; Yang et al. 2002; Zhu et al. 2004; Tomlinson et al. 2006). Some of the factors that regulate trafficking of these two core components of telomerase have been identified, such as nucleolin (Khurts et al. 2004), SMN (Bachand et al. 2002), and 14-3-3 (Seimiya et al. 2000). Cytological studies of HeLa cells suggest that the localization of the telomerase core components can change through the cell-cycle (Jady et al. 2006; Tomlinson et al. 2006). Despite these studies, it is not clear in which compartment hTERT and hTERC assemble to form functional telomerase RNP.
The assembly of telomerase involves the chaperone proteins p23 and Hsp90, which stably associate with telomerase in vitro (Holt et al. 1999; Forsythe et al. 2001; Keppler et al. 2006). A number of other proteins interact with the telomerase RNP, but it is not clear if they play a role in telomerase assembly. Interestingly, assembled human telomerase RNP can multimerize, though the function of multimerization remains unclear (Beattie et al. 2001; Wenz et al. 2001; Arai et al. 2002).",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"O60832-1",
"Q9Y230-1",
"O14746-1",
"Q9Y265-1"
],
"evidence": [
{
"id": "R-HSA-164616",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-164616"
}
]
},
{
"id": "R-HSA-164617",
"name": "Elongation of Extended Telomeric Chromosome End",
"equation": "",
"summary": "The elongation reaction proceeds as follows: The template of hTERC directs the sequential addition of nucleotides to the 3' telomeric DNA end. Following addition of a nucleotide, the template and catalytic site must move relative to one another within the telomerase RNP to place the appropriate template residue in the active site. As base-pairing and nucleotide addition occur at one end of the template, base pair melting occurs at the other (Collins and Greider 1993; Wang and Blackburn, 1997; Hammond and Cech 1998; Benjamin et al. 2000; Forstemann and Lingner 2005). This un-pairing is thought to reduce the energy used for mediating the subsequent translocation step. Nucleotide addition can occur up until the template boundary which in hTERC is defined by a helix called P1b (Chen and Greider 2003).
",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q9NZ71-1",
"O60832-1",
"O14746-1"
],
"evidence": [
{
"id": "R-HSA-164617",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-164617"
}
]
},
{
"id": "R-HSA-164620",
"name": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End",
"equation": "",
"summary": "The human telomerase RNP can catalyze multiple rounds of repeat addition on the same telomeric substrate in vitro. Before initiating synthesis of another repeat, telomerase undergoes a translocation step to reposition itself on the telomere. Base pairs in the DNA/RNA hybrid are unannealed, the RNA template is repositioned relative to the active site, and the template base-pairs at the 3' end of the newly synthesized DNA. The anchor site interaction with DNA 5' of the RNA-DNA duplex is thought to maintain the interaction of telomerase with DNA during the translocation step.",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q9NZ71-1",
"O60832-1",
"O14746-1"
],
"evidence": [
{
"id": "R-HSA-164620",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-164620"
}
]
},
{
"id": "R-HSA-3322422",
"name": "Beta-catenin recruits SMARCA4",
"equation": "",
"summary": "SMARCA4, one of two ATPase components of SWI/SNF chromatin remodelling complexes, was identified in a two-hybrid screen for beta-catenin interactors that activate TCF/LEF-dependent transcription (Barker et al, 2001; Wilson and Roberts, 2011). SMARCA4 co-immunoprecipitates with beta-catenin when both tagged proteins are expressed in HEK293 cells; likewise, tagged SMARCA4 co-precipitates endogenous beta-catenin from a colon carcinoma cell line. Expression of SMARCA4 enhances the expression of a TCF reporter in a manner that depends on a functional ATPase domain, indicating a probable role for chromatin remodelling at WNT-responsive promoters (Barker et al, 2001). By ChIP, SMARCA4 and beta-catenin are associated with WNT-responsive promoters upon WNT pathway stimulation; this study also identified TERT, a telomerase reverse transcriptase, as SMARCA4-interacting protein that is present at WNT promoters (Park et al, 2009).",
"cellular_location": "nucleoplasm",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P51532-1",
"O14746-1"
],
"evidence": [
{
"id": "R-HSA-3322422",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3322422"
}
]
}
],
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"participant_name": "H+ [nucleoplasm]",
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{
"participant_id": "R-HSA-5686112",
"participant_name": "RTEL1 [nucleoplasm]",
"crossref": [
{
"id": "ENST00000508582",
"database": "Ensembl",
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{
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{
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{
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},
{
"id": "Q9NZ71",
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},
{
"id": "ENSG00000258366-RTEL1",
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"url": ""
},
{
"id": "ENST00000370018",
"database": "Ensembl",
"url": ""
},
{
"id": "Q9NZ71",
"database": "UniProt",
"url": ""
},
{
"id": "ENSG00000258366",
"database": "OpenTargets",
"url": ""
},
{
"id": "ENSP00000359035",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000424307",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_001269939.1",
"database": "RefSeq",
"url": ""
},
{
"id": "Q9NZ71",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "21975",
"database": "Orphanet",
"url": ""
},
{
"id": "ENSP00000353332",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000322287",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_057518.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENST00000318100",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000457868",
"database": "Ensembl",
"url": ""
}
]
}
],
"reaction_enzymes": [
{
"uniprot_ac": "A0A0B7P3V8",
"gene_name": "TY4B-P",
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{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "A0A0B7P3V8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0B7P3V8"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "A0A0B7P3V8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0B7P3V8"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
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{
"id": "A0A0B7P3V8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0B7P3V8"
}
]
},
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "A0A0B7P3V8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0B7P3V8"
}
]
}
]
},
{
"uniprot_ac": "D3Z8X4",
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{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
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{
"id": "D3Z8X4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3Z8X4"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "D3Z8X4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3Z8X4"
}
]
}
]
},
{
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{
"ec_number": "2.7.7.31",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "E9PT58",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9PT58"
}
]
},
{
"ec_number": "2.7.7.31",
"activity": "",
"evidence": [
{
"id": "E9PT58",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9PT58"
}
]
}
]
},
{
"uniprot_ac": "F1M8G6",
"gene_name": "Rev3l",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "F1M8G6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1M8G6"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "F1M8G6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1M8G6"
}
]
}
]
},
{
"uniprot_ac": "F7F6Z7",
"gene_name": "Polm",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "F7F6Z7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F7F6Z7"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "F7F6Z7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F7F6Z7"
}
]
}
]
},
{
"uniprot_ac": "O00370",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "O00370",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00370"
}
]
},
{
"ec_number": "3.1.21.-",
"activity": "",
"evidence": [
{
"id": "O00370",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00370"
}
]
}
]
},
{
"uniprot_ac": "O00743",
"gene_name": "PPP6C",
"activity": [
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "O00743",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00743"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "",
"evidence": [
{
"id": "O00743",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00743"
}
]
}
]
},
{
"uniprot_ac": "O13527",
"gene_name": "TY1B-A",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "O13527",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O13527"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "O13527",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O13527"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "O13527",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O13527"
}
]
}
]
},
{
"uniprot_ac": "O13535",
"gene_name": "TY1B-H",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "O13535",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O13535"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "O13535",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O13535"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "O13535",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O13535"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "O13535",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O13535"
}
]
}
]
},
{
"uniprot_ac": "O14746",
"gene_name": "TERT",
"activity": [
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "O14746",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14746"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "",
"evidence": [
{
"id": "O14746",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14746"
}
]
}
]
},
{
"uniprot_ac": "O18475",
"gene_name": "PolQ",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "O18475",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O18475"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "O18475",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O18475"
}
]
}
]
},
{
"uniprot_ac": "O54747",
"gene_name": "Pold1",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "O54747",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54747"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "O54747",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54747"
}
]
},
{
"ec_number": "3.1.11.-",
"activity": "",
"evidence": [
{
"id": "O54747",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54747"
}
]
}
]
},
{
"uniprot_ac": "O60673",
"gene_name": "REV3L",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "O60673",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60673"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "O60673",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60673"
}
]
}
]
},
{
"uniprot_ac": "O60832",
"gene_name": "DKC1",
"activity": [
{
"ec_number": "5.4.99.-",
"activity": "",
"evidence": [
{
"id": "O60832",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60832"
}
]
}
]
},
{
"uniprot_ac": "O70372",
"gene_name": "Tert",
"activity": [
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "O70372",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O70372"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "",
"evidence": [
{
"id": "O70372",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O70372"
}
]
}
]
},
{
"uniprot_ac": "O75417",
"gene_name": "POLQ",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "O75417",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75417"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "O75417",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75417"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "O75417",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75417"
}
]
}
]
},
{
"uniprot_ac": "O89042",
"gene_name": "Pola1",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "O89042",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O89042"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "O89042",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O89042"
}
]
}
]
},
{
"uniprot_ac": "P04053",
"gene_name": "DNTT",
"activity": [
{
"ec_number": "2.7.7.31",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P04053",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04053"
}
]
},
{
"ec_number": "2.7.7.31",
"activity": "",
"evidence": [
{
"id": "P04053",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04053"
}
]
}
]
},
{
"uniprot_ac": "P06746",
"gene_name": "POLB",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P06746",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06746"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "P06746",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06746"
}
]
},
{
"ec_number": "4.2.99.18",
"activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).",
"evidence": [
{
"id": "P06746",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06746"
}
]
},
{
"ec_number": "4.2.99.-",
"activity": "",
"evidence": [
{
"id": "P06746",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06746"
}
]
}
]
},
{
"uniprot_ac": "P06766",
"gene_name": "Polb",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P06766",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06766"
}
]
},
{
"ec_number": "4.2.99.18",
"activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).",
"evidence": [
{
"id": "P06766",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06766"
}
]
},
{
"ec_number": "4.2.99.-",
"activity": "",
"evidence": [
{
"id": "P06766",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06766"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "P06766",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06766"
}
]
}
]
},
{
"uniprot_ac": "P09838",
"gene_name": "Dntt",
"activity": [
{
"ec_number": "3.1.11.-",
"activity": "",
"evidence": [
{
"id": "P09838",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09838"
}
]
},
{
"ec_number": "2.7.7.31",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P09838",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09838"
}
]
},
{
"ec_number": "2.7.7.31",
"activity": "",
"evidence": [
{
"id": "P09838",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09838"
}
]
}
]
},
{
"uniprot_ac": "P09884",
"gene_name": "POLA1",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P09884",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09884"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "P09884",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09884"
}
]
}
]
},
{
"uniprot_ac": "P0C2I2",
"gene_name": "TY1B-DR5",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P0C2I2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2I2"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "P0C2I2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2I2"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P0C2I2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2I2"
}
]
},
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "P0C2I2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2I2"
}
]
}
]
},
{
"uniprot_ac": "P0C2I3",
"gene_name": "TY1B-DR6",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "P0C2I3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2I3"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P0C2I3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2I3"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "P0C2I3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2I3"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P0C2I3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2I3"
}
]
}
]
},
{
"uniprot_ac": "P0C2I5",
"gene_name": "TY1B-LR2",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "P0C2I5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2I5"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P0C2I5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2I5"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "P0C2I5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2I5"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P0C2I5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2I5"
}
]
}
]
},
{
"uniprot_ac": "P0C2I6",
"gene_name": "TY1B-LR3",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "P0C2I6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2I6"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P0C2I6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2I6"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "P0C2I6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2I6"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P0C2I6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2I6"
}
]
}
]
},
{
"uniprot_ac": "P0C2I9",
"gene_name": "TY1B-PR1",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "P0C2I9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2I9"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P0C2I9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2I9"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "P0C2I9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2I9"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P0C2I9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2I9"
}
]
}
]
},
{
"uniprot_ac": "P0C2J0",
"gene_name": "TY1B-PR2",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "P0C2J0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2J0"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P0C2J0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2J0"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "P0C2J0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2J0"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P0C2J0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2J0"
}
]
}
]
},
{
"uniprot_ac": "P0C2J1",
"gene_name": "TY1B-PR3",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "P0C2J1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2J1"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P0C2J1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2J1"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "P0C2J1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2J1"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P0C2J1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2J1"
}
]
}
]
},
{
"uniprot_ac": "P0C2J3",
"gene_name": "TY2B-LR1",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P0C2J3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2J3"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "P0C2J3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2J3"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P0C2J3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2J3"
}
]
},
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "P0C2J3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2J3"
}
]
}
]
},
{
"uniprot_ac": "P0C2J7",
"gene_name": "TY4B-H",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P0C2J7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2J7"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "P0C2J7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2J7"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P0C2J7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2J7"
}
]
},
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "P0C2J7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C2J7"
}
]
}
]
},
{
"uniprot_ac": "P0CX63",
"gene_name": "TY2B-F",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P0CX63",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0CX63"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "P0CX63",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0CX63"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P0CX63",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0CX63"
}
]
},
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "P0CX63",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0CX63"
}
]
}
]
},
{
"uniprot_ac": "P0CX64",
"gene_name": "TY2B-GR2",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P0CX64",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0CX64"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "P0CX64",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0CX64"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P0CX64",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0CX64"
}
]
},
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "P0CX64",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0CX64"
}
]
}
]
},
{
"uniprot_ac": "P10266",
"gene_name": "ERVK-10",
"activity": [
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P10266",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10266"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "P10266",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10266"
}
]
},
{
"ec_number": "3.4.23.50",
"activity": "Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-|-PIVQ- cleavage site.",
"evidence": [
{
"id": "P10266",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10266"
}
]
}
]
},
{
"uniprot_ac": "P10400",
"gene_name": "Pol",
"activity": [
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P10400",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10400"
}
]
}
]
},
{
"uniprot_ac": "P11369",
"gene_name": "Pol",
"activity": [
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P11369",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11369"
}
]
},
{
"ec_number": "3.1.21.-",
"activity": "",
"evidence": [
{
"id": "P11369",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11369"
}
]
}
]
},
{
"uniprot_ac": "P13382",
"gene_name": "POL1",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P13382",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13382"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "P13382",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13382"
}
]
}
]
},
{
"uniprot_ac": "P14284",
"gene_name": "REV3",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P14284",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P14284"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "P14284",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P14284"
}
]
}
]
},
{
"uniprot_ac": "P15436",
"gene_name": "POL3",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P15436",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15436"
}
]
},
{
"ec_number": "3.1.11.-",
"activity": "",
"evidence": [
{
"id": "P15436",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15436"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "P15436",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15436"
}
]
}
]
},
{
"uniprot_ac": "P15801",
"gene_name": "MIP1",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P15801",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15801"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "P15801",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15801"
}
]
}
]
},
{
"uniprot_ac": "P21951",
"gene_name": "POL2",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P21951",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P21951"
}
]
},
{
"ec_number": "3.1.11.-",
"activity": "",
"evidence": [
{
"id": "P21951",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P21951"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "P21951",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P21951"
}
]
}
]
},
{
"uniprot_ac": "P24941",
"gene_name": "CDK2",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P24941",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24941"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P24941",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24941"
}
]
}
]
},
{
"uniprot_ac": "P25384",
"gene_name": "TY2B-C",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P25384",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25384"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "P25384",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25384"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P25384",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25384"
}
]
},
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "P25384",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25384"
}
]
}
]
},
{
"uniprot_ac": "P25615",
"gene_name": "POL4",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P25615",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25615"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "P25615",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25615"
}
]
}
]
},
{
"uniprot_ac": "P26019",
"gene_name": "PolA1",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P26019",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P26019"
}
]
},
{
"ec_number": "3.1.11.-",
"activity": "",
"evidence": [
{
"id": "P26019",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P26019"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "P26019",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P26019"
}
]
}
]
},
{
"uniprot_ac": "P28340",
"gene_name": "POLD1",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P28340",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28340"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "P28340",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28340"
}
]
},
{
"ec_number": "3.1.11.-",
"activity": "",
"evidence": [
{
"id": "P28340",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28340"
}
]
}
]
},
{
"uniprot_ac": "P33609",
"gene_name": "Pola1",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P33609",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33609"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "P33609",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33609"
}
]
}
]
},
{
"uniprot_ac": "P39985",
"gene_name": "POL5",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P39985",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P39985"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "P39985",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P39985"
}
]
}
]
},
{
"uniprot_ac": "P46957",
"gene_name": "POL31",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P46957",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P46957"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "P46957",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P46957"
}
]
}
]
},
{
"uniprot_ac": "P47024",
"gene_name": "TY4B-J",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P47024",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P47024"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "P47024",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P47024"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P47024",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P47024"
}
]
},
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "P47024",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P47024"
}
]
}
]
},
{
"uniprot_ac": "P47098",
"gene_name": "TY1B-JR1",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "P47098",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P47098"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P47098",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P47098"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "P47098",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P47098"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P47098",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P47098"
}
]
}
]
},
{
"uniprot_ac": "P47100",
"gene_name": "TY1B-JR2",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "P47100",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P47100"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P47100",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P47100"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "P47100",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P47100"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P47100",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P47100"
}
]
}
]
},
{
"uniprot_ac": "P51532",
"gene_name": "SMARCA4",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P51532",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51532"
}
]
}
]
},
{
"uniprot_ac": "P52431",
"gene_name": "Pold1",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P52431",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P52431"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "P52431",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P52431"
}
]
},
{
"ec_number": "3.1.11.-",
"activity": "",
"evidence": [
{
"id": "P52431",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P52431"
}
]
}
]
},
{
"uniprot_ac": "P54098",
"gene_name": "POLG",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P54098",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54098"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "P54098",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54098"
}
]
}
]
},
{
"uniprot_ac": "P54099",
"gene_name": "Polg",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P54099",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54099"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "P54099",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54099"
}
]
}
]
},
{
"uniprot_ac": "P54358",
"gene_name": "PolD1",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P54358",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54358"
}
]
},
{
"ec_number": "3.1.11.-",
"activity": "",
"evidence": [
{
"id": "P54358",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54358"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "P54358",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54358"
}
]
}
]
},
{
"uniprot_ac": "P63128",
"gene_name": "ERVK-9",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P63128",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63128"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "P63128",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63128"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P63128",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63128"
}
]
},
{
"ec_number": "3.4.23.50",
"activity": "Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-|-PIVQ- cleavage site.",
"evidence": [
{
"id": "P63128",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63128"
}
]
}
]
},
{
"uniprot_ac": "P63132",
"gene_name": "HERVK_113",
"activity": [
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P63132",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63132"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "P63132",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63132"
}
]
}
]
},
{
"uniprot_ac": "P63133",
"gene_name": "ERVK-8",
"activity": [
{
"ec_number": "3.4.23.50",
"activity": "Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-|-PIVQ- cleavage site.",
"evidence": [
{
"id": "P63133",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63133"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P63133",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63133"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "P63133",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63133"
}
]
}
]
},
{
"uniprot_ac": "P63135",
"gene_name": "ERVK-7",
"activity": [
{
"ec_number": "3.4.23.50",
"activity": "Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-|-PIVQ- cleavage site.",
"evidence": [
{
"id": "P63135",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63135"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P63135",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63135"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "P63135",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63135"
}
]
}
]
},
{
"uniprot_ac": "P63136",
"gene_name": "ERVK-25",
"activity": [
{
"ec_number": "3.4.23.50",
"activity": "Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-|-PIVQ- cleavage site.",
"evidence": [
{
"id": "P63136",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63136"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "P63136",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63136"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "P63136",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63136"
}
]
}
]
},
{
"uniprot_ac": "Q03434",
"gene_name": "TY1B-ML2",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q03434",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03434"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q03434",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03434"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q03434",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03434"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q03434",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03434"
}
]
}
]
},
{
"uniprot_ac": "Q03494",
"gene_name": "TY2B-DR2",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q03494",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03494"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q03494",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03494"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q03494",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03494"
}
]
},
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q03494",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03494"
}
]
}
]
},
{
"uniprot_ac": "Q03612",
"gene_name": "TY1B-ER1",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q03612",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03612"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q03612",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03612"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q03612",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03612"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q03612",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03612"
}
]
}
]
},
{
"uniprot_ac": "Q03619",
"gene_name": "TY1B-ER2",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q03619",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03619"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q03619",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03619"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q03619",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03619"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q03619",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03619"
}
]
}
]
},
{
"uniprot_ac": "Q03855",
"gene_name": "TY1B-DR1",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q03855",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03855"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q03855",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03855"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q03855",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03855"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q03855",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03855"
}
]
}
]
},
{
"uniprot_ac": "Q04049",
"gene_name": "RAD30",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q04049",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04049"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "Q04049",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04049"
}
]
}
]
},
{
"uniprot_ac": "Q04214",
"gene_name": "TY1B-MR1",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q04214",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04214"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q04214",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04214"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q04214",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04214"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q04214",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04214"
}
]
}
]
},
{
"uniprot_ac": "Q04670",
"gene_name": "TY1B-MR2",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q04670",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04670"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q04670",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04670"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q04670",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04670"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q04670",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04670"
}
]
}
]
},
{
"uniprot_ac": "Q04711",
"gene_name": "TY1B-ML1",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q04711",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04711"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q04711",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04711"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q04711",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04711"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q04711",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04711"
}
]
}
]
},
{
"uniprot_ac": "Q06163",
"gene_name": "EST2",
"activity": [
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q06163",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q06163"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "",
"evidence": [
{
"id": "Q06163",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q06163"
}
]
}
]
},
{
"uniprot_ac": "Q07791",
"gene_name": "TY2B-DR3",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q07791",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07791"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q07791",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07791"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q07791",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07791"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q07791",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07791"
}
]
}
]
},
{
"uniprot_ac": "Q07793",
"gene_name": "TY1B-DR4",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q07793",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07793"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q07793",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07793"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q07793",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07793"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q07793",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07793"
}
]
}
]
},
{
"uniprot_ac": "Q07864",
"gene_name": "POLE",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q07864",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07864"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "Q07864",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07864"
}
]
},
{
"ec_number": "3.1.11.-",
"activity": "",
"evidence": [
{
"id": "Q07864",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07864"
}
]
}
]
},
{
"uniprot_ac": "Q12088",
"gene_name": "TY1B-LR1",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q12088",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12088"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q12088",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12088"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q12088",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12088"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q12088",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12088"
}
]
}
]
},
{
"uniprot_ac": "Q12112",
"gene_name": "TY1B-NL1",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q12112",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12112"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q12112",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12112"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q12112",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12112"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q12112",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12112"
}
]
}
]
},
{
"uniprot_ac": "Q12113",
"gene_name": "TY2B-OR1",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q12113",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12113"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q12113",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12113"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q12113",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12113"
}
]
},
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q12113",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12113"
}
]
}
]
},
{
"uniprot_ac": "Q12141",
"gene_name": "TY1B-GR1",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q12141",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12141"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q12141",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12141"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q12141",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12141"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q12141",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12141"
}
]
}
]
},
{
"uniprot_ac": "Q12193",
"gene_name": "TY1B-BR",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q12193",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12193"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q12193",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12193"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q12193",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12193"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q12193",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12193"
}
]
}
]
},
{
"uniprot_ac": "Q12269",
"gene_name": "TY1B-GR2",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q12269",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12269"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q12269",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12269"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q12269",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12269"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q12269",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12269"
}
]
}
]
},
{
"uniprot_ac": "Q12273",
"gene_name": "TY1B-OL",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q12273",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12273"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q12273",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12273"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q12273",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12273"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q12273",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12273"
}
]
}
]
},
{
"uniprot_ac": "Q12316",
"gene_name": "TY1B-GR3",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q12316",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12316"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q12316",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12316"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q12316",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12316"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q12316",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12316"
}
]
}
]
},
{
"uniprot_ac": "Q12414",
"gene_name": "TY1B-PL",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q12414",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12414"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q12414",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12414"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q12414",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12414"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q12414",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12414"
}
]
}
]
},
{
"uniprot_ac": "Q12472",
"gene_name": "TY2B-DR1",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q12472",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12472"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q12472",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12472"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q12472",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12472"
}
]
},
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q12472",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12472"
}
]
}
]
},
{
"uniprot_ac": "Q12490",
"gene_name": "TY1B-BL",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q12490",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12490"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q12490",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12490"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q12490",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12490"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q12490",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12490"
}
]
}
]
},
{
"uniprot_ac": "Q12491",
"gene_name": "TY2B-B",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q12491",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12491"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q12491",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12491"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q12491",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12491"
}
]
},
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q12491",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12491"
}
]
}
]
},
{
"uniprot_ac": "Q12501",
"gene_name": "TY2B-OR2",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q12501",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12501"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q12501",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12501"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q12501",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12501"
}
]
},
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q12501",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12501"
}
]
}
]
},
{
"uniprot_ac": "Q1ZXF2",
"gene_name": "polB",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q1ZXF2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q1ZXF2"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "Q1ZXF2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q1ZXF2"
}
]
}
]
},
{
"uniprot_ac": "Q27607",
"gene_name": "PolG1",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q27607",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q27607"
}
]
},
{
"ec_number": "3.1.11.-",
"activity": "",
"evidence": [
{
"id": "Q27607",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q27607"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "Q27607",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q27607"
}
]
}
]
},
{
"uniprot_ac": "Q54B44",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q54B44",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54B44"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "",
"evidence": [
{
"id": "Q54B44",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54B44"
}
]
}
]
},
{
"uniprot_ac": "Q54N97",
"gene_name": "pold1",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q54N97",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54N97"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "Q54N97",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54N97"
}
]
}
]
},
{
"uniprot_ac": "Q54RD4",
"gene_name": "pole",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q54RD4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54RD4"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "Q54RD4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54RD4"
}
]
}
]
},
{
"uniprot_ac": "Q54SV8",
"gene_name": "pola1",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q54SV8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54SV8"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "Q54SV8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54SV8"
}
]
}
]
},
{
"uniprot_ac": "Q55AZ3",
"gene_name": "polZ",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q55AZ3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55AZ3"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "Q55AZ3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55AZ3"
}
]
}
]
},
{
"uniprot_ac": "Q5RKI3",
"gene_name": "Poll",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q5RKI3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5RKI3"
}
]
},
{
"ec_number": "4.2.99.-",
"activity": "",
"evidence": [
{
"id": "Q5RKI3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5RKI3"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "Q5RKI3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5RKI3"
}
]
}
]
},
{
"uniprot_ac": "Q61493",
"gene_name": "Rev3l",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q61493",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61493"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "Q61493",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61493"
}
]
}
]
},
{
"uniprot_ac": "Q673L6",
"gene_name": "Tert",
"activity": [
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q673L6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q673L6"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "",
"evidence": [
{
"id": "Q673L6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q673L6"
}
]
}
]
},
{
"uniprot_ac": "Q6R3M4",
"gene_name": "Poli",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q6R3M4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6R3M4"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "Q6R3M4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6R3M4"
}
]
}
]
},
{
"uniprot_ac": "Q7LHG5",
"gene_name": "TY3B-I",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q7LHG5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7LHG5"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q7LHG5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7LHG5"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q7LHG5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7LHG5"
}
]
},
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q7LHG5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7LHG5"
}
]
}
]
},
{
"uniprot_ac": "Q7TQ07",
"gene_name": "Poln",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q7TQ07",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7TQ07"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "Q7TQ07",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7TQ07"
}
]
}
]
},
{
"uniprot_ac": "Q7Z5Q5",
"gene_name": "POLN",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q7Z5Q5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z5Q5"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "Q7Z5Q5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z5Q5"
}
]
}
]
},
{
"uniprot_ac": "Q8CGS6",
"gene_name": "Polq",
"activity": [
{
"ec_number": "3.6.4.12",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "Q8CGS6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CGS6"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q8CGS6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CGS6"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q8CGS6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CGS6"
}
]
}
]
},
{
"uniprot_ac": "Q8K409",
"gene_name": "Polb",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q8K409",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K409"
}
]
},
{
"ec_number": "4.2.99.18",
"activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).",
"evidence": [
{
"id": "Q8K409",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K409"
}
]
},
{
"ec_number": "4.2.99.-",
"activity": "",
"evidence": [
{
"id": "Q8K409",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K409"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "",
"evidence": [
{
"id": "Q8K409",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K409"
}
]
}
]
},
{
"uniprot_ac": "Q92393",
"gene_name": "TY1B-OR",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q92393",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92393"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q92393",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92393"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q92393",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92393"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q92393",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92393"
}
]
}
]
},
{
"uniprot_ac": "Q99231",
"gene_name": "TY1B-DR3",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q99231",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99231"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q99231",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99231"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q99231",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99231"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q99231",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99231"
}
]
}
]
},
{
"uniprot_ac": "Q99315",
"gene_name": "TY3B-G",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q99315",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99315"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q99315",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99315"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q99315",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99315"
}
]
},
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q99315",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99315"
}
]
}
]
},
{
"uniprot_ac": "Q99337",
"gene_name": "TY1B-NL2",
"activity": [
{
"ec_number": "3.4.23.-",
"activity": "",
"evidence": [
{
"id": "Q99337",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99337"
}
]
},
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q99337",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99337"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q99337",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99337"
}
]
},
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q99337",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99337"
}
]
}
]
},
{
"uniprot_ac": "Q9BXR3",
"gene_name": "ERVK-6",
"activity": [
{
"ec_number": "2.7.7.49",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q9BXR3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BXR3"
}
]
},
{
"ec_number": "3.1.26.4",
"activity": "Endonucleolytic cleavage to 5'-phosphomonoester.",
"evidence": [
{
"id": "Q9BXR3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BXR3"
}
]
},
{
"ec_number": "3.4.23.50",
"activity": "Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-|-PIVQ- cleavage site.",
"evidence": [
{
"id": "Q9BXR3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BXR3"
}
]
}
]
},
{
"uniprot_ac": "Q9GSR1",
"gene_name": "PolZ1",
"activity": [
{
"ec_number": "2.7.7.7",
"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).",
"evidence": [
{
"id": "Q9GSR1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9GSR1"
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