{ "uniprot_canonical_ac": "O14531-1", "uniprot_ac": "O14531", "uniprot_id": "DPYL4_HUMAN", "mass": { "chemical_mass": 61878.0, "monoisotopic_mass": 61878.0 }, "refseq": { "ac": "NP_006417", "name": "dihydropyrimidinase-related protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006417" }, "gene_names": [ { "name": "DPYSL4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O14531", "id": "O14531" }, { "name": "CRMP3; DRP-4; ULIP4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006417", "id": "NP_006417" }, { "name": "CRMP3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O14531", "id": "O14531" }, { "name": "DPYSL4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006417", "id": "NP_006417" }, { "name": "ULIP4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O14531", "id": "O14531" } ], "protein_names": [ { "name": "Dihydropyrimidinase-related protein 4", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O14531" }, { "name": "CRMP-3; ULIP-4; UNC33-like phosphoprotein 4; collapsin response mediator protein 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006417", "id": "NP_006417" }, { "name": "CRMP-3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14531" }, { "name": "Collapsin response mediator protein 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14531" }, { "name": "DRP-4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14531" }, { "name": "ULIP-4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14531" }, { "name": "UNC33-like phosphoprotein 4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O14531" }, { "name": "dihydropyrimidinase-related protein 4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006417", "id": "NP_006417" } ], "function": [ { "annotation": "DPYSL4 is a novel apoptosis-inducible factor controlled by p53 in response to DNA damage", "evidence": [ { "database": "RefSeq", "id": "NP_006417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006417" }, { "database": "PubMed", "id": "20499313", "url": "https://glygen.org/publication/PubMed/20499313" } ] }, { "annotation": "DPYSL4 plays a key role in the tumor-suppressor function of p53 by regulating oxidative phosphorylation and the cellular energy supply via its association with mitochondrial supercomplexes, possibly linking to the pathophysiology of both cancer and obesity.", "evidence": [ { "database": "RefSeq", "id": "NP_006417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006417" }, { "database": "PubMed", "id": "30061407", "url": "https://glygen.org/publication/PubMed/30061407" } ] }, { "annotation": "Identification of Metabolic Syndrome-Related miRNA-mRNA Regulatory Networks and Key Genes Based on Bioinformatics Analysis.", "evidence": [ { "database": "RefSeq", "id": "NP_006417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006417" }, { "database": "PubMed", "id": "35877019", "url": "https://glygen.org/publication/PubMed/35877019" } ] }, { "annotation": "Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. 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"https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": 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"https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", 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"MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O14531", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14531" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14531" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "O14531", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O14531" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", 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"https://www.ebi.ac.uk/interpro/entry/IPR011778", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032466", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032466", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:10570", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:10570", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "608407", "url": "http://www.omim.org/entry/608407", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O14531", "url": "https://www.nextprot.org/entry/NX_O14531", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "O14531", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O14531", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "PWHHGTS", "url": "https://omabrowser.org/oma/group/PWHHGTS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "1772494at2759", "url": "http://www.orthodb.org/?query=1772494at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11647", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11647", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11647:SF55", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11647:SF55", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "5NKS", "url": "https://www.rcsb.org/structure/5NKS", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF01979", "url": "http://pfam.xfam.org/family/PF01979", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O14531", "url": "https://pharos.nih.gov/targets/O14531", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O14531", "url": "http://purl.obolibrary.org/obo/PR_O14531", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-399956", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399956", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_006417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006417", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "O14531", "url": "https://www.uniprot.org/uniprot/O14531", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O14531-1", "url": "https://www.uniprot.org/uniprot/O14531-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5T0Q6", "url": "https://www.uniprot.org/uniprot/Q5T0Q6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5T0Q6-1", "url": "https://www.uniprot.org/uniprot/Q5T0Q6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSFQGKKSIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYKRIKARNRLAEIHGVPRGLYDGPVHEVMVPAKPGSGAPARASCPGKISVPPVRNLHQSGFSLSGSQADDHIARRTAQKIMAPPGGRSNITSLS", "length": 572, "header": "sp|O14531-1|DPYL4_HUMAN Isoform 1 of Dihydropyrimidinase-related protein 4 OS=Homo sapiens OX=9606 GN=DPYSL4 PE=1 SV=2 CANONICAL=O14531-1" }, "isoforms": [ { "isoform_ac": "O14531-1", "url": "", "sequence": { "sequence": "MSFQGKKSIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRAVTIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPRKTFPDFVYKRIKARNRLAEIHGVPRGLYDGPVHEVMVPAKPGSGAPARASCPGKISVPPVRNLHQSGFSLSGSQADDHIARRTAQKIMAPPGGRSNITSLS", "length": 572, "header": "sp|O14531-1|DPYL4_HUMAN Isoform 1 of Dihydropyrimidinase-related protein 4 OS=Homo sapiens OX=9606 GN=DPYSL4 PE=1 SV=2 CANONICAL=O14531-1" }, "locus": { "chromosome": "10", "start_pos": 132204927, "end_pos": 132187064, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000338492.9", "url": "https://www.ensembl.org/id/ENST00000338492.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000339850.3", "url": "https://www.ensembl.org/id/ENSP00000339850.3" } ] } }, { "isoform_ac": "Q5T0Q6-1", "url": "", "sequence": { "sequence": "MPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYSLHVDITRWHESIKEELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQVHAENGDIVEEVEAEAVYRAVTIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAAFVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKMDENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLLAEIHGVPRGLYDGPVHEVMVPAKPGSGAPARASCPGKISVPPVRNLHQSGFSLSGSQADDHIARRTAQKIMAPPGGRSNITSLS", "length": 412, "header": "tr|Q5T0Q6-1|DPYL4_HUMAN Computationally mapped isoform of Dihydropyrimidinase-related protein 4 OS=Homo sapiens OX=9606 GN=DPYSL4 PE=1 SV=1 CANONICAL=O14531-1" }, "locus": { "chromosome": "10", "start_pos": 132204927, "end_pos": 132192761, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000368627.1", "url": "https://www.ensembl.org/id/ENST00000368627.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000357616.1", "url": "https://www.ensembl.org/id/ENSP00000357616.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O14531", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O14531" }, { "id": "29485866", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29485866" } ] } ], "phosphorylation": [ { "start_pos": 537, "end_pos": 537, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O14531", "url": "https://www.uniprot.org/uniprot/O14531" } ], "site_lbl": "Ser537" }, { "start_pos": 544, "end_pos": 544, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O14531", "url": "https://www.uniprot.org/uniprot/O14531" }, { "database": "iPTMnet", "id": "O14531", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14531" }, { "database": "PubMed", "id": "17525332", "url": "https://glygen.org/publication/PubMed/17525332" }, { "database": "phospho.ELM", "id": "O14531", "url": "http://phospho.elm.eu.org/byAccession/O14531.html" }, { "database": "PRO", "id": "O14531", "url": "http://purl.obolibrary.org/obo/O14531" } ], "site_lbl": "Ser544" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling.", "journal": "The EMBO journal", "date": "2002", "authors": "Mitsui N, Inatome R, Takahashi S, Goshima Y, Yamamura H, Yanagi S", "evidence": [ { "database": "Reactome", "id": "R-HSA-399956", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399956" } ], "reference": [ { "type": "PubMed", "id": "12093729", "url": "https://glygen.org/publication/PubMed/12093729" } ] }, { "title": "Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex.", "journal": "Neuron", "date": "2002", "authors": "Sasaki Y, Cheng C, Uchida Y, Nakajima O, Ohshima T, Yagi T, Taniguchi M, Nakayama T, Kishida R, Kudo Y, Ohno S, Nakamura F, Goshima Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-399956", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399956" } ], "reference": [ { "type": "PubMed", "id": "12372285", "url": "https://glygen.org/publication/PubMed/12372285" } ] }, { "title": "Structural bases for CRMP function in plexin-dependent semaphorin3A signaling.", "journal": "The EMBO journal", "date": "2004", "authors": "Deo RC, Schmidt EF, Elhabazi A, Togashi H, Burley SK, Strittmatter SM", "evidence": [ { "database": "Reactome", "id": "R-HSA-399956", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399956" } ], "reference": [ { "type": "PubMed", "id": "14685275", "url": "https://glygen.org/publication/PubMed/14685275" } ] }, { "title": "GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity.", "journal": "Cell", "date": "2005", "authors": "Yoshimura T, Kawano Y, Arimura N, Kawabata S, Kikuchi A, Kaibuchi K", "evidence": [ { "database": "Reactome", "id": "R-HSA-399956", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399956" } ], "reference": [ { "type": "PubMed", "id": "15652488", "url": "https://glygen.org/publication/PubMed/15652488" } ] }, { "title": "Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease.", "journal": "Genes to cells : devoted to molecular & cellular mechanisms", "date": "2005", "authors": "Uchida Y, Ohshima T, Sasaki Y, Suzuki H, Yanai S, Yamashita N, Nakamura F, Takei K, Ihara Y, Mikoshiba K, Kolattukudy P, Honnorat J, Goshima Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-399956", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399956" } ], "reference": [ { "type": "PubMed", "id": "15676027", "url": "https://glygen.org/publication/PubMed/15676027" } ] }, { "title": "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.", "journal": "Science (New York, N.Y.)", "date": "2007", "authors": "Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ", "evidence": [ { "database": "iPTMnet", "id": "O14531", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O14531" } ], "reference": [ { "type": "PubMed", "id": "17525332", "url": "https://glygen.org/publication/PubMed/17525332" } ] }, { "title": "The CRMP family of proteins and their role in Sema3A signaling.", "journal": "Advances in experimental medicine and biology", "date": "2007", "authors": "Schmidt EF, Strittmatter SM", "evidence": [ { "database": "Reactome", "id": "R-HSA-399956", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399956" } ], "reference": [ { "type": "PubMed", "id": "17607942", "url": "https://glygen.org/publication/PubMed/17607942" } ] }, { "title": "Intracellular kinases in semaphorin signaling.", "journal": "Advances in experimental medicine and biology", "date": "2007", "authors": "Ahmed A, Eickholt BJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-399956", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399956" } ], "reference": [ { "type": "PubMed", "id": "17607944", "url": "https://glygen.org/publication/PubMed/17607944" } ] }, { "title": "Identification of dihydropyrimidinase-related protein 4 as a novel target of the p53 tumor suppressor in the apoptotic response to DNA damage.", "journal": "International journal of cancer", "date": "2011", "authors": "Kimura J, Kudoh T, Miki Y, Yoshida K", "evidence": [ { "database": "RefSeq", "id": "NP_006417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006417" } ], "reference": [ { "type": "PubMed", "id": "20499313", "url": "https://glygen.org/publication/PubMed/20499313" } ] }, { "title": "Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling.", "journal": "Nat. Commun.", "date": "2014", "authors": "Nakamura F, Kumeta K, Hida T, Isono T, Nakayama Y, Kuramata-Matsuoka E, Yamashita N, Uchida Y, Ogura K, Gengyo-Ando K, Mitani S, Ogino T, Goshima Y", "evidence": [ { "database": "UniProtKB", "id": "O14531", "url": "https://www.uniprot.org/uniprot/O14531" } ], "reference": [ { "type": "PubMed", "id": "25358863", "url": "https://glygen.org/publication/PubMed/25358863" } ] }, { "title": "O-GlcNAc Transferase Recognizes Protein Substrates Using an Asparagine Ladder in the Tetratricopeptide Repeat (TPR) Superhelix.", "journal": "Journal of the American Chemical Society", "date": "2018", "authors": "Levine ZG, Fan C, Melicher MS, Orman M, Benjamin T, Walker S", "evidence": [ { "database": "O-GlcNAc Database", "id": "O14531", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O14531" } ], "reference": [ { "type": "PubMed", "id": "29485866", "url": "https://glygen.org/publication/PubMed/29485866" } ] }, { "title": "p53-inducible DPYSL4 associates with mitochondrial supercomplexes and regulates energy metabolism in adipocytes and cancer cells.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2018", "authors": "Nagano H, Hashimoto N, Nakayama A, Suzuki S, Miyabayashi Y, Yamato A, Higuchi S, Fujimoto M, Sakuma I, Beppu M, Yokoyama M, Suzuki Y, Sugano S, Ikeda K, Tatsuno I, Manabe I, Yokote K, Inoue S, Tanaka T", "evidence": [ { "database": "RefSeq", "id": "NP_006417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006417" } ], "reference": [ { "type": "PubMed", "id": "30061407", "url": "https://glygen.org/publication/PubMed/30061407" } ] }, { "title": "Identification of Metabolic Syndrome-Related miRNA-mRNA Regulatory Networks and Key Genes Based on Bioinformatics Analysis.", "journal": "Biochemical genetics", "date": "2022-07-25", "authors": "Qiu Lingyan, Sheng Pei, Wang Xu", "evidence": [ { "database": "RefSeq", "id": "NP_006417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006417" } ], "reference": [ { "type": "PubMed", "id": "35877019", "url": "https://glygen.org/publication/PubMed/35877019" } ] }, { "title": "The Ulip family phosphoproteins -- common and specific properties.", "journal": "Eur. J. Biochem.", "date": "1998", "authors": "Byk T, Ozon S, Sobel A", "evidence": [ { "database": "UniProtKB", "id": "O14531", "url": "https://www.uniprot.org/uniprot/O14531" } ], "reference": [ { "type": "PubMed", "id": "9652388", "url": "https://glygen.org/publication/PubMed/9652388" } ] } ], "pathway": [ { "id": "hsa:10570", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:10570", "resource": "KEGG Pathway" }, { "id": "R-HSA-399956", "name": "CRMPs in Sema3A signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399956", "resource": "Reactome", "description": "CRMPs in Sema3A signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480URP4-1", "protein_name": "Dihydropyrimidinase-related protein 4", "gene_name": "DPYSL4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": 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