{ "uniprot_canonical_ac": "O00571-1", "uniprot_ac": "O00571", "uniprot_id": "DDX3X_HUMAN", "mass": { "chemical_mass": 73243.0, "monoisotopic_mass": 73243.0 }, "refseq": { "ac": "NP_001180345", "name": "ATP-dependent RNA helicase DDX3X isoform 2", "summary": "The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180345" }, "gene_names": [ { "name": "DDX3X", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O00571", "id": "O00571" }, { "name": "CAP-Rf; DBX; DDX14; DDX3; HLP2; MRX102; MRXSSB", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180345", "id": "NP_001180345" }, { "name": "DBX", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O00571", "id": "O00571" }, { "name": "DDX3X", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180345", "id": "NP_001180345" }, { "name": "DDX3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O00571", "id": "O00571" } ], "protein_names": [ { "name": "ATP-dependent RNA helicase DDX3X", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O00571" }, { "name": "3.6.4.13", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00571" }, { "name": "ATP-dependent RNA helicase DDX3X isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180345", "id": "NP_001180345" }, { "name": "CAP-Rf", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00571" }, { "name": "DBX", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00571" }, { "name": "DEAD box protein 3, X-chromosomal", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00571" }, { "name": "DEAD box, X isoform", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00571" }, { "name": "DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3; DEAD/H box-3; ATP-dependent RNA helicase DDX3X; helicase-like protein 2; DEAD box protein 3, X-chromosomal; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180345", "id": "NP_001180345" }, { "name": "HLP2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00571" }, { "name": "Helicase-like protein 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00571" } ], "function": [ { "annotation": "(Microbial infection) Facilitates Dengue virus (DENV) replication.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571#function" }, { "database": "PubMed", "id": "29899501", "url": "https://glygen.org/publication/PubMed/29899501" } ] }, { "annotation": "(Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960).", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571#function" }, { "database": "PubMed", "id": "21589879", "url": "https://glygen.org/publication/PubMed/21589879" }, { "database": "PubMed", "id": "22872150", "url": "https://glygen.org/publication/PubMed/22872150" }, { "database": "PubMed", "id": "15507209", "url": "https://glygen.org/publication/PubMed/15507209" }, { "database": "PubMed", "id": "18583960", "url": "https://glygen.org/publication/PubMed/18583960" }, { "database": "PubMed", "id": "29899501", "url": "https://glygen.org/publication/PubMed/29899501" } ] }, { "annotation": "(Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571#function" }, { "database": "PubMed", "id": "27105836", "url": "https://glygen.org/publication/PubMed/27105836" } ] }, { "annotation": "(Microbial infection) Facilitates Zika virus (ZIKV) replication.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571#function" }, { "database": "PubMed", "id": "29899501", "url": "https://glygen.org/publication/PubMed/29899501" } ] }, { "annotation": "(Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385).", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571#function" }, { "database": "PubMed", "id": "21170385", "url": "https://glygen.org/publication/PubMed/21170385" }, { "database": "PubMed", "id": "29899501", "url": "https://glygen.org/publication/PubMed/29899501" } ] }, { "annotation": "Data suggest complex translational control mechanism(s) for the human DDX3X gene locus functioning only in the male germ line and resulting in expression of its protein only in the postmeiotic spermatids.", "evidence": [ { "database": "RefSeq", "id": "NP_001180345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180345" }, { "database": "PubMed", "id": "25208899", "url": "https://glygen.org/publication/PubMed/25208899" } ] }, { "annotation": "Genetic and phenotypic findings in 34 novel Spanish patients with DDX3X neurodevelopmental disorder.", "evidence": [ { "database": "RefSeq", "id": "NP_001180345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180345" }, { "database": "PubMed", "id": "37904618", "url": "https://glygen.org/publication/PubMed/37904618" } ] }, { "annotation": "ITPR1-AS1 promotes small cell lung cancer metastasis by facilitating P21[HRAS] splicing and stabilizing DDX3X to activate the cRaf-MEK-ERK cascade.", "evidence": [ { "database": "RefSeq", "id": "NP_001180345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180345" }, { "database": "PubMed", "id": "37820992", "url": "https://glygen.org/publication/PubMed/37820992" } ] }, { "annotation": "Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:18628297, PubMed:17667941, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:31575075, PubMed:20127681, PubMed:21170385). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:21170385, PubMed:27980081, PubMed:19913487). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191).", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571#function" }, { "database": "PubMed", "id": "18628297", "url": "https://glygen.org/publication/PubMed/18628297" }, { "database": "PubMed", "id": "22323517", "url": "https://glygen.org/publication/PubMed/22323517" }, { "database": "PubMed", "id": "21589879", "url": "https://glygen.org/publication/PubMed/21589879" }, { "database": "PubMed", "id": "18846110", "url": "https://glygen.org/publication/PubMed/18846110" }, { "database": "PubMed", "id": "21170385", "url": "https://glygen.org/publication/PubMed/21170385" }, { "database": "PubMed", "id": "17667941", "url": "https://glygen.org/publication/PubMed/17667941" }, { "database": "PubMed", "id": "22872150", "url": "https://glygen.org/publication/PubMed/22872150" }, { "database": "PubMed", "id": "23413191", "url": "https://glygen.org/publication/PubMed/23413191" }, { "database": "PubMed", "id": "18636090", "url": "https://glygen.org/publication/PubMed/18636090" }, { "database": "UniProtKB", "id": "Q62167", "url": "https://www.uniprot.org/uniprot/Q62167#function" }, { "database": "PubMed", "id": "19913487", "url": "https://glygen.org/publication/PubMed/19913487" }, { "database": "PubMed", "id": "18583960", "url": "https://glygen.org/publication/PubMed/18583960" }, { "database": "PubMed", "id": "21730191", "url": "https://glygen.org/publication/PubMed/21730191" }, { "database": "PubMed", "id": "20127681", "url": "https://glygen.org/publication/PubMed/20127681" }, { "database": "PubMed", "id": "17357160", "url": "https://glygen.org/publication/PubMed/17357160" }, { "database": "PubMed", "id": "18264132", "url": "https://glygen.org/publication/PubMed/18264132" }, { "database": "PubMed", "id": "27736973", "url": "https://glygen.org/publication/PubMed/27736973" }, { "database": "PubMed", "id": "21883093", "url": "https://glygen.org/publication/PubMed/21883093" }, { "database": "PubMed", "id": "16818630", "url": "https://glygen.org/publication/PubMed/16818630" }, { "database": "PubMed", "id": "28128295", "url": "https://glygen.org/publication/PubMed/28128295" }, { "database": "PubMed", "id": "31575075", "url": "https://glygen.org/publication/PubMed/31575075" }, { "database": "PubMed", "id": "23478265", "url": "https://glygen.org/publication/PubMed/23478265" }, { "database": "PubMed", "id": "29222110", "url": "https://glygen.org/publication/PubMed/29222110" }, { "database": "PubMed", "id": "27980081", "url": "https://glygen.org/publication/PubMed/27980081" }, { "database": "PubMed", "id": "30341167", "url": "https://glygen.org/publication/PubMed/30341167" }, { "database": "PubMed", "id": "18596238", "url": "https://glygen.org/publication/PubMed/18596238" }, { "database": "PubMed", "id": "28842590", "url": "https://glygen.org/publication/PubMed/28842590" }, { "database": "PubMed", "id": "17095540", "url": "https://glygen.org/publication/PubMed/17095540" }, { "database": "PubMed", "id": "29062139", "url": "https://glygen.org/publication/PubMed/29062139" }, { "database": "PubMed", "id": "30256975", "url": "https://glygen.org/publication/PubMed/30256975" }, { "database": "PubMed", "id": "20837705", "url": "https://glygen.org/publication/PubMed/20837705" } ] }, { "annotation": "Perturbation Analysis of a Prognostic DDX3X-Mediated Gene Expression Signature Identifies the Antimetastatic Potential of Chaetocin in Hepatocellular Carcinoma. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001180345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180345" }, { "database": "PubMed", "id": "37371098", "url": "https://glygen.org/publication/PubMed/37371098" } ] }, { "annotation": "The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014].", "evidence": [ { "database": "RefSeq", "id": "NP_001180345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180345" } ] }, { "annotation": "This review discusses the considerable body of work on the biochemistry and biology of DDX3, including the recently discovered link of human DDX3 to tumorigenesis. Review article", "evidence": [ { "database": "RefSeq", "id": "NP_001180345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180345" }, { "database": "PubMed", "id": "25039764", "url": "https://glygen.org/publication/PubMed/25039764" } ] } ], "disease": [ { "disease_id": "MONDO:0010497", "recommended_name": { "id": "MONDO:0010497", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010497", "name": "intellectual disability, X-linked 102", "description": "An inherited condition caused by mutation(s) in the DDX3X gene, encoding ATP-dependent RNA helicase DDX3X. It is characterized by severe intellectual disability and variable neurologic features." }, "synonyms": [ { "id": "MONDO:0010497", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010497", "name": "DDX3X non-syndromic X-linked intellectual disability", "description": "" }, { "id": "MONDO:0010497", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010497", "name": "intellectual developmental disorder, X-linked, syndrome, Snijders Blok type, X-linked recessive, X-linked dominant", "description": "" }, { "id": "MONDO:0010497", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010497", "name": "intellectual disability, X-linked 102", "description": "" }, { "id": "MONDO:0010497", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010497", "name": "intellectual disability, X-linked type 102", "description": "" }, { "id": "MONDO:0010497", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010497", "name": "mental retardation, X-linked type 102", "description": "" }, { "id": "MONDO:0010497", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010497", "name": "non-syndromic X-linked intellectual disability caused by mutation in DDX3X", "description": "" }, { "id": "MONDO:0010497", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010497", "name": "DDX3X-related intellectual disability", "description": "" }, { "id": "MONDO:0010497", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010497", "name": "MRX102", "description": "" }, { "id": "MONDO:0010497", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010497", "name": "mental retardation, X-linked 102", "description": "" }, { "id": "MIM:300958", "resource": "MIM", "url": "https://www.omim.org/entry/300958", "name": "Intellectual developmental disorder, X-linked, syndromic, Snijders Blok type", "description": "Intellectual developmental disorder, X-linked, syndromic, Snijders Blok type" } ], "evidence": [ { "id": "300958", "database": "MIM", "url": "https://www.omim.org/entry/300958" } ] } ], "snv": [ { "evidence": [ { "id": "rs746566984", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs746566984" }, { "id": "rs746566984", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs746566984" }, { "id": "rs746566984", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs746566984" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 474, "end_pos": 474, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DRS->NRS).", "chr_id": "X", "chr_pos": "41346333", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D474", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1198871978", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1198871978" }, { "id": "rs1198871978", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1198871978" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 56, "end_pos": 56, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DSS->NSS).", "chr_id": "X", "chr_pos": "41341498", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D56", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs781633738", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs781633738" }, { "id": "rs781633738", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs781633738" }, { "id": "rs781633738", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs781633738" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 575, "end_pos": 575, "sequence_org": "A", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NMA->NMT).", "chr_id": "X", "chr_pos": "41347364", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A575", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs868308965", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs868308965" }, { "id": "rs868308965", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs868308965" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 611, "end_pos": 611, "sequence_org": "S", "sequence_mut": "R", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->R).", "chr_id": "X", "chr_pos": "41347378", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S611", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1369281442", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1369281442" }, { "id": "rs1369281442", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1369281442#frequency_tab" }, { "id": "rs1369281442", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1369281442" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 61, "end_pos": 61, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SSS->NSS).", "chr_id": "X", "chr_pos": "41341514", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S61", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [ { "start_pos": 102, "end_pos": 102, "sequence_org": "S", "sequence_mut": "A", "comment": "Reduces total phosphorylation by 30%. Abolishes interaction with IRF3 and fails to enhance IFNB promoter induction. No effect on interaction with IKBKE.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "23478265", "url": "https://glygen.org/publication/PubMed/23478265" } ] }, { "start_pos": 102, "end_pos": 102, "sequence_org": "S", "sequence_mut": "D", "comment": "Interacts with IRF3 and enhances IFNB promoter induction.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "23478265", "url": "https://glygen.org/publication/PubMed/23478265" } ] }, { "start_pos": 12, "end_pos": 21, "sequence_org": "LDQQFAGLDL", "sequence_mut": "ADQQAAGADA", "comment": "Impairs nuclear export and interaction with XPO1/CMR1.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "31575075", "url": "https://glygen.org/publication/PubMed/31575075" } ] }, { "start_pos": 142, "end_pos": 144, "sequence_org": "PSE", "sequence_mut": "ASA", "comment": "Loss of interaction with TRAF3, reduced TRAF3 'K-63'-linked autoubiquitination.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "27980081", "url": "https://glygen.org/publication/PubMed/27980081" } ] }, { "start_pos": 152, "end_pos": 152, "sequence_org": "S", "sequence_mut": "A", "comment": "Reduces total phosphorylation by 60%. No effect on interaction with IKBKE.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "23478265", "url": "https://glygen.org/publication/PubMed/23478265" } ] }, { "start_pos": 181, "end_pos": 181, "sequence_org": "S", "sequence_mut": "A", "comment": "Greatly impairs phosphorylation by TBK1 and fails to synergize with TBK1 in IFNB1 induction; when associated with A-183; A-240 and A-269.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "18583960", "url": "https://glygen.org/publication/PubMed/18583960" } ] }, { "start_pos": 183, "end_pos": 183, "sequence_org": "S", "sequence_mut": "A", "comment": "Greatly impairs phosphorylation by TBK1 and fails to synergize with TBK1 in IFN-beta induction; when associated with A-181; A-240 and A-269.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "18583960", "url": "https://glygen.org/publication/PubMed/18583960" } ] }, { "start_pos": 19, "end_pos": 21, "sequence_org": "LDL", "sequence_mut": "ADA", "comment": "Impairs nuclear export and interaction with XPO1/CMR1.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "30131165", "url": "https://glygen.org/publication/PubMed/30131165" } ] }, { "start_pos": 200, "end_pos": 200, "sequence_org": "Y", "sequence_mut": "A", "comment": "No effect on general translation; when associated with A-207; A-230; A-347 and A-348.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "22323517", "url": "https://glygen.org/publication/PubMed/22323517" } ] }, { "start_pos": 207, "end_pos": 207, "sequence_org": "Q", "sequence_mut": "A", "comment": "Does not promote the translation of HIV-1 RNA. No effect on general translation; when associated with A-200; A-230: A-347 and A-348.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "22323517", "url": "https://glygen.org/publication/PubMed/22323517" }, { "database": "PubMed", "id": "22872150", "url": "https://glygen.org/publication/PubMed/22872150" } ] }, { "start_pos": 230, "end_pos": 230, "sequence_org": "K", "sequence_mut": "A", "comment": "No effect on general translation; when associated with A-200; A-207; A-347 and A-348.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "22323517", "url": "https://glygen.org/publication/PubMed/22323517" } ] }, { "start_pos": 230, "end_pos": 230, "sequence_org": "K", "sequence_mut": "E", "comment": "Complete loss of ATPase and RNA-unwinding activities. Loss of HIV-1 mRNA nuclear export. Does not promote the translation of HIV-1 RNA. No effect on IFNB1 induction. No effect on RNA-binding. Loss of inhibition of NF-kappa-B-mediated transcriptional activity.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "21589879", "url": "https://glygen.org/publication/PubMed/21589879" }, { "database": "PubMed", "id": "22872150", "url": "https://glygen.org/publication/PubMed/22872150" }, { "database": "PubMed", "id": "18636090", "url": "https://glygen.org/publication/PubMed/18636090" }, { "database": "PubMed", "id": "15507209", "url": "https://glygen.org/publication/PubMed/15507209" }, { "database": "PubMed", "id": "18583960", "url": "https://glygen.org/publication/PubMed/18583960" }, { "database": "PubMed", "id": "27736973", "url": "https://glygen.org/publication/PubMed/27736973" } ] }, { "start_pos": 240, "end_pos": 240, "sequence_org": "S", "sequence_mut": "A", "comment": "Greatly impairs phosphorylation by TBK1 and fails to synergize with TBK1 in IFN-beta induction; when associated with A-181; A-183 and A-269.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "18583960", "url": "https://glygen.org/publication/PubMed/18583960" } ] }, { "start_pos": 269, "end_pos": 269, "sequence_org": "S", "sequence_mut": "A", "comment": "Greatly impairs phosphorylation by TBK1 and fails to synergize with TBK1 in IFN-beta induction; when associated with A-181; A-183 and A-240.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "18583960", "url": "https://glygen.org/publication/PubMed/18583960" } ] }, { "start_pos": 275, "end_pos": 277, "sequence_org": "TRE", "sequence_mut": "RRV", "comment": "Increased NF-kappa-B-mediated transcriptional activity, contrary to wild-type which is inhibitory in this experimental setting.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "27736973", "url": "https://glygen.org/publication/PubMed/27736973" } ] }, { "start_pos": 347, "end_pos": 347, "sequence_org": "D", "sequence_mut": "A", "comment": "No effect on general translation; when associated with A-200; A-207; A-230 and A-348.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "22323517", "url": "https://glygen.org/publication/PubMed/22323517" } ] }, { "start_pos": 347, "end_pos": 350, "sequence_org": "DEAD", "sequence_mut": "AEAA", "comment": "Loss of ATPase activity.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "21589879", "url": "https://glygen.org/publication/PubMed/21589879" } ] }, { "start_pos": 348, "end_pos": 348, "sequence_org": "E", "sequence_mut": "A", "comment": "No effect on general translation; when associated with A-200; A-207; A-230 and A-347.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "22323517", "url": "https://glygen.org/publication/PubMed/22323517" }, { "database": "PubMed", "id": "22872150", "url": "https://glygen.org/publication/PubMed/22872150" } ] }, { "start_pos": 348, "end_pos": 348, "sequence_org": "E", "sequence_mut": "Q", "comment": "Loss of both ATPase and RNA helicase activities; decreased up-regulation of CDKN1A promoter activity and HNF4A-mediated MTTP transcriptional activation; no effect on the repression of cap- and IRES-dependent translation, WNT/beta catenin signaling, nor on stress granule assembly. Does not promote the translation of HIV-1 RNA.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "22323517", "url": "https://glygen.org/publication/PubMed/22323517" }, { "database": "PubMed", "id": "17667941", "url": "https://glygen.org/publication/PubMed/17667941" }, { "database": "PubMed", "id": "22872150", "url": "https://glygen.org/publication/PubMed/22872150" }, { "database": "PubMed", "id": "23413191", "url": "https://glygen.org/publication/PubMed/23413191" }, { "database": "PubMed", "id": "21883093", "url": "https://glygen.org/publication/PubMed/21883093" } ] }, { "start_pos": 382, "end_pos": 382, "sequence_org": "S", "sequence_mut": "L", "comment": "Strong decrease in ATPase activity and RNA-unwinding activity. Does not promote the translation of mRNAs containing long structured 5'UTRs, including that of CCNE1. No effect on the translation of HIV-1 RNA.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "22872150", "url": "https://glygen.org/publication/PubMed/22872150" }, { "database": "PubMed", "id": "15507209", "url": "https://glygen.org/publication/PubMed/15507209" }, { "database": "PubMed", "id": "18596238", "url": "https://glygen.org/publication/PubMed/18596238" }, { "database": "PubMed", "id": "20837705", "url": "https://glygen.org/publication/PubMed/20837705" } ] }, { "start_pos": 382, "end_pos": 384, "sequence_org": "SAT", "sequence_mut": "AAA", "comment": "Loss of RNA helicase, but not ATPase activity; no effect on the repression of cap- and IRES-dependent translation, WNT/beta catenin signaling, up-regulation of CDKN1A promoter activity, HNF4A-mediated MTTP transcriptional activation, nor on stress granule assembly.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "17667941", "url": "https://glygen.org/publication/PubMed/17667941" }, { "database": "PubMed", "id": "23413191", "url": "https://glygen.org/publication/PubMed/23413191" }, { "database": "PubMed", "id": "21883093", "url": "https://glygen.org/publication/PubMed/21883093" }, { "database": "PubMed", "id": "28128295", "url": "https://glygen.org/publication/PubMed/28128295" } ] }, { "start_pos": 38, "end_pos": 38, "sequence_org": "Y", "sequence_mut": "A", "comment": "Impaired interaction with EIF4E; impaired stress granule formation, decreased repression of cap-dependent translation and decreased ability to enhance IRES-mediated translation. No effect on translation of HIV-1 RNA; when associated with A-43.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "17667941", "url": "https://glygen.org/publication/PubMed/17667941" }, { "database": "PubMed", "id": "22872150", "url": "https://glygen.org/publication/PubMed/22872150" }, { "database": "PubMed", "id": "21883093", "url": "https://glygen.org/publication/PubMed/21883093" } ] }, { "start_pos": 429, "end_pos": 429, "sequence_org": "S", "sequence_mut": "A", "comment": "Impairs phosphorylation by TBK1 and fails to synergize with TBK1 in IFN-beta induction; when associated with A-438; A-442; A-456 and A-520.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "18583960", "url": "https://glygen.org/publication/PubMed/18583960" } ] }, { "start_pos": 438, "end_pos": 438, "sequence_org": "T", "sequence_mut": "A", "comment": "Impairs phosphorylation by TBK1 and fails to synergize with TBK1 in IFN-beta induction; when associated with A-429; A-442; A-456 and A-520.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "18583960", "url": "https://glygen.org/publication/PubMed/18583960" } ] }, { "start_pos": 43, "end_pos": 43, "sequence_org": "L", "sequence_mut": "A", "comment": "Impaired interaction with EIF4E; decreased repression of cap-dependent translation. Fails to induce stress granule assembly and to rescue cell viability after stress. No effect on translation of HIV-1 RNA; when associated with A-38.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "17667941", "url": "https://glygen.org/publication/PubMed/17667941" }, { "database": "PubMed", "id": "22872150", "url": "https://glygen.org/publication/PubMed/22872150" }, { "database": "PubMed", "id": "21883093", "url": "https://glygen.org/publication/PubMed/21883093" } ] }, { "start_pos": 442, "end_pos": 442, "sequence_org": "S", "sequence_mut": "A", "comment": "Impairs phosphorylation by TBK1 and fails to synergize with TBK1 in IFN-beta induction; when associated with A-429; A-438; A-456 and A-520.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "18583960", "url": "https://glygen.org/publication/PubMed/18583960" } ] }, { "start_pos": 456, "end_pos": 456, "sequence_org": "S", "sequence_mut": "A", "comment": "Impairs phosphorylation by TBK1 and fails to synergize with TBK1 in IFN-beta induction; when associated with A-429; A-438; A-442 and A-520.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "18583960", "url": "https://glygen.org/publication/PubMed/18583960" } ] }, { "start_pos": 520, "end_pos": 520, "sequence_org": "S", "sequence_mut": "A", "comment": "Impairs phosphorylation by TBK1 and fails to synergize with TBK1 in IFN-beta induction; when associated with A-429; A-438; A-442 and A-456.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "18583960", "url": "https://glygen.org/publication/PubMed/18583960" } ] }, { "start_pos": 71, "end_pos": 71, "sequence_org": "S", "sequence_mut": "A", "comment": "Reduces total phosphorylation by 60%. No effect on interaction with IKBKE.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "23478265", "url": "https://glygen.org/publication/PubMed/23478265" } ] }, { "start_pos": 82, "end_pos": 83, "sequence_org": "SS", "sequence_mut": "AA", "comment": "Reduces total phosphorylation by 50%. No effect on interaction with IKBKE.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "23478265", "url": "https://glygen.org/publication/PubMed/23478265" } ] }, { "start_pos": 84, "end_pos": 85, "sequence_org": "FF", "sequence_mut": "AA", "comment": "Loss of interaction with VACV protein K7, IRF3 activation and IFNB1 promoter induction.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "19913487", "url": "https://glygen.org/publication/PubMed/19913487" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "96.96", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000215301", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000215301" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "98.55", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000215301", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000215301" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "97.81", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000215301", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000215301" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "98.72", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000215301", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000215301" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "98.65", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000215301", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000215301" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "98.16", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000215301", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000215301" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "96.95", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000215301", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000215301" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "98.54", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000215301", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000215301" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "97.56", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000215301", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000215301" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "99.2", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000215301", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000215301" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "98.51", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000215301", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000215301" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "95.93", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000215301", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000215301" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "98.57", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000215301", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000215301" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O00571", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00571" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": 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"https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": 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"url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": 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"resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", 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"https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O00571", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00571" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00571" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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"http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Uterine cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:363", 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"UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8YF31", "url": "https://www.uniprot.org/uniprot/A0A2R8YF31", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8YF31-1", "url": "https://www.uniprot.org/uniprot/A0A2R8YF31-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8YF78", "url": "https://www.uniprot.org/uniprot/A0A2R8YF78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8YF78-1", "url": "https://www.uniprot.org/uniprot/A0A2R8YF78-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8YF89", "url": "https://www.uniprot.org/uniprot/A0A2R8YF89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8YF89-1", "url": "https://www.uniprot.org/uniprot/A0A2R8YF89-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8YFR4", "url": "https://www.uniprot.org/uniprot/A0A2R8YFR4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8YFR4-1", "url": "https://www.uniprot.org/uniprot/A0A2R8YFR4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8YFS5", "url": "https://www.uniprot.org/uniprot/A0A2R8YFS5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8YFS5-1", "url": "https://www.uniprot.org/uniprot/A0A2R8YFS5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8YGJ1", "url": "https://www.uniprot.org/uniprot/A0A2R8YGJ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8YGJ1-1", "url": "https://www.uniprot.org/uniprot/A0A2R8YGJ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2U3TZJ9", "url": "https://www.uniprot.org/uniprot/A0A2U3TZJ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2U3TZJ9-1", "url": "https://www.uniprot.org/uniprot/A0A2U3TZJ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6S8Q4", "url": "https://www.uniprot.org/uniprot/F6S8Q4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6S8Q4-1", "url": "https://www.uniprot.org/uniprot/F6S8Q4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00571-1", "url": "https://www.uniprot.org/uniprot/O00571-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00571-2", "url": "https://www.uniprot.org/uniprot/O00571-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN", "length": 662, "header": "sp|O00571-1|DDX3X_HUMAN Isoform 1 of ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=3 CANONICAL=O00571-1" }, "isoforms": [ { "isoform_ac": "A0A087WVZ1-1", "url": "", "sequence": { "sequence": "XSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGSSRSQEEMKGTISSPVQKVV", "length": 189, "header": "tr|A0A087WVZ1-1|A0A087WVZ1_HUMAN Computationally mapped isoform of DEAD-box helicase 3 X-linked OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=2 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41347923, "end_pos": 41346320, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000611968.2", "url": "https://www.ensembl.org/id/ENST00000611968.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000479790.2", "url": "https://www.ensembl.org/id/ENSP00000479790.2" } ] } }, { "isoform_ac": "A0A087WX09-1", "url": "", "sequence": { "sequence": "MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGSVVN", "length": 98, "header": "tr|A0A087WX09-1|DDX3X_HUMAN Computationally mapped isoform of ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=1 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41341958, "end_pos": 41334253, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000615742.4", "url": "https://www.ensembl.org/id/ENST00000615742.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000480647.1", "url": "https://www.ensembl.org/id/ENSP00000480647.1" } ] } }, { "isoform_ac": "A0A0D9SF53-1", "url": "", "sequence": { "sequence": "MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGSSRSQEEMKGTISSPVQKDHAPLWSKCLHEMPYFVKKVHAGIFRSPACSHGSLRYLRPTNPPDEDNHNSCRHESNLERDAQKCVNWSVTTKMRTAC", "length": 733, "header": "tr|A0A0D9SF53-1|A0A0D9SF53_HUMAN Computationally mapped isoform of RNA helicase OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=1 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41364339, "end_pos": 41334253, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000625837.2", "url": "https://www.ensembl.org/id/ENST00000625837.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000486306.1", "url": "https://www.ensembl.org/id/ENSP00000486306.1" } ] } }, { "isoform_ac": "A0A0D9SFB3-1", "url": "", "sequence": { "sequence": "MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGELGA", "length": 640, "header": "tr|A0A0D9SFB3-1|DDX3X_HUMAN Computationally mapped isoform of ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=1 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41364284, "end_pos": 41334253, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000626301.2", "url": "https://www.ensembl.org/id/ENST00000626301.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000486443.1", "url": "https://www.ensembl.org/id/ENSP00000486443.1" } ] } }, { "isoform_ac": "A0A0D9SG12-1", "url": "", "sequence": { "sequence": "MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGSCSSVEQVPP", "length": 647, "header": "tr|A0A0D9SG12-1|DDX3X_HUMAN Computationally mapped isoform of ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=1 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41357864, "end_pos": 41334253, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000630370.2", "url": "https://www.ensembl.org/id/ENST00000630370.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000487062.1", "url": "https://www.ensembl.org/id/ENSP00000487062.1" } ] } }, { "isoform_ac": "A0A0J9YVQ7-1", "url": "", "sequence": { "sequence": "XVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGELGA", "length": 222, "header": "tr|A0A0J9YVQ7-1|DDX3X_HUMAN Computationally mapped isoform of ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=2 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41364285, "end_pos": 41345486, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000616050.3", "url": "https://www.ensembl.org/id/ENST00000616050.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000487626.2", "url": "https://www.ensembl.org/id/ENSP00000487626.2" } ] } }, { "isoform_ac": "A0A2R8Y4A4-1", "url": "", "sequence": { "sequence": "MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGSGYGGFYNSDGYGGNYNSQGVDWWGN", "length": 662, "header": "tr|A0A2R8Y4A4-1|A0A2R8Y4A4_HUMAN Computationally mapped isoform of RNA helicase OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=1 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41347716, "end_pos": 41334253, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000644513.1", "url": "https://www.ensembl.org/id/ENST00000644513.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000493819.1", "url": "https://www.ensembl.org/id/ENSP00000493819.1" } ] } }, { "isoform_ac": "A0A2R8Y4D2-1", "url": "", "sequence": { "sequence": "MGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGKWKVWAPQTIPNLLGISTNERVGSTDLRGSQKIFIPI", "length": 78, "header": "tr|A0A2R8Y4D2-1|DDX3X_HUMAN Computationally mapped isoform of ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=1 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41344252, "end_pos": 41343231, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000542215.5", "url": "https://www.ensembl.org/id/ENST00000542215.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000493687.1", "url": "https://www.ensembl.org/id/ENSP00000493687.1" } ] } }, { "isoform_ac": "A0A2R8Y5G6-1", "url": "", "sequence": { "sequence": "MNTTSKKHGNNGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN", "length": 622, "header": "tr|A0A2R8Y5G6-1|A0A2R8Y5G6_HUMAN Computationally mapped isoform of RNA helicase OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=1 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41347716, "end_pos": 41340781, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000644677.1", "url": "https://www.ensembl.org/id/ENST00000644677.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000496524.1", "url": "https://www.ensembl.org/id/ENSP00000496524.1" } ] } }, { "isoform_ac": "A0A2R8Y645-1", "url": "", "sequence": { "sequence": "MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASRRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYVLFCFCFFVLFCFVLLFLAELRSCCPGWSAMARSRLTTTSASRVQAILLPQPPRYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN", "length": 716, "header": "tr|A0A2R8Y645-1|A0A2R8Y645_HUMAN Computationally mapped isoform of RNA helicase OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=1 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41347716, "end_pos": 41334253, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000644109.1", "url": "https://www.ensembl.org/id/ENST00000644109.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000494952.1", "url": "https://www.ensembl.org/id/ENSP00000494952.1" } ] } }, { "isoform_ac": "A0A2R8Y650-1", "url": "", "sequence": { "sequence": "MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESGLEKLQHFCCPS", "length": 193, "header": "tr|A0A2R8Y650-1|DDX3X_HUMAN Computationally mapped isoform of ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=1 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41343772, "end_pos": 41334253, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000643963.1", "url": "https://www.ensembl.org/id/ENST00000643963.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000495264.1", "url": "https://www.ensembl.org/id/ENSP00000495264.1" } ] } }, { "isoform_ac": "A0A2R8Y770-1", "url": "", "sequence": { "sequence": "MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGIPDCHQAYSR", "length": 61, "header": "tr|A0A2R8Y770-1|A0A2R8Y770_HUMAN Computationally mapped isoform of DEAD-box helicase 3 X-linked OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=1 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41340667, "end_pos": 41334253, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000646223.1", "url": "https://www.ensembl.org/id/ENST00000646223.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000496043.1", "url": "https://www.ensembl.org/id/ENSP00000496043.1" } ] } }, { "isoform_ac": "A0A2R8Y774-1", "url": "", "sequence": { "sequence": "MRESRLISDLGGFAGVRSAAGRDWRPFWLGGLRPSRLAQPGFPSGGPGGTRCLRACEQGFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN", "length": 706, "header": "tr|A0A2R8Y774-1|A0A2R8Y774_HUMAN Computationally mapped isoform of RNA helicase OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=1 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41347716, "end_pos": 41334593, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000642322.2", "url": "https://www.ensembl.org/id/ENST00000642322.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000496052.2", "url": "https://www.ensembl.org/id/ENSP00000496052.2" } ] } }, { "isoform_ac": "A0A2R8Y7T2-1", "url": "", "sequence": { "sequence": "MGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN", "length": 476, "header": "tr|A0A2R8Y7T2-1|A0A2R8Y7T2_HUMAN Computationally mapped isoform of RNA helicase OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=1 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41347716, "end_pos": 41343231, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000646627.1", "url": "https://www.ensembl.org/id/ENST00000646627.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000493795.1", "url": "https://www.ensembl.org/id/ENSP00000493795.1" } ] } }, { "isoform_ac": "A0A2R8YCU0-1", "url": "", "sequence": { "sequence": "MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIES", "length": 181, "header": "tr|A0A2R8YCU0-1|A0A2R8YCU0_HUMAN Computationally mapped isoform of DEAD-box helicase 3 X-linked OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=1 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41342836, "end_pos": 41334253, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000642793.1", "url": "https://www.ensembl.org/id/ENST00000642793.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000493976.1", "url": "https://www.ensembl.org/id/ENSP00000493976.1" } ] } }, { "isoform_ac": "A0A2R8YCW1-1", "url": "", "sequence": { "sequence": "MFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN", "length": 647, "header": "tr|A0A2R8YCW1-1|A0A2R8YCW1_HUMAN Computationally mapped isoform of RNA helicase OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=1 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41347716, "end_pos": 41336157, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000644073.1", "url": "https://www.ensembl.org/id/ENST00000644073.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000493475.1", "url": "https://www.ensembl.org/id/ENSP00000493475.1" } ] } }, { "isoform_ac": "A0A2R8YDH3-1", "url": "", "sequence": { "sequence": "MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATALFSR", "length": 503, "header": "tr|A0A2R8YDH3-1|DDX3X_HUMAN Computationally mapped isoform of ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=1 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41346505, "end_pos": 41334253, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000645589.1", "url": "https://www.ensembl.org/id/ENST00000645589.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000494588.1", "url": "https://www.ensembl.org/id/ENSP00000494588.1" } ] } }, { "isoform_ac": "A0A2R8YDT5-1", "url": "", "sequence": { "sequence": "MGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN", "length": 475, "header": "tr|A0A2R8YDT5-1|A0A2R8YDT5_HUMAN Computationally mapped isoform of RNA helicase OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=1 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41347716, "end_pos": 41343231, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000646679.1", "url": "https://www.ensembl.org/id/ENST00000646679.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000494887.1", "url": "https://www.ensembl.org/id/ENSP00000494887.1" } ] } }, { "isoform_ac": "A0A2R8YF31-1", "url": "", "sequence": { "sequence": "MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASSWSAMV", "length": 40, "header": "tr|A0A2R8YF31-1|A0A2R8YF31_HUMAN Computationally mapped isoform of DEAD-box helicase 3 X-linked OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=1 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41337707, "end_pos": 41334253, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000645783.1", "url": "https://www.ensembl.org/id/ENST00000645783.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000494905.1", "url": "https://www.ensembl.org/id/ENSP00000494905.1" } ] } }, { "isoform_ac": "A0A2R8YF78-1", "url": "", "sequence": { "sequence": "MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGSVNL", "length": 641, "header": "tr|A0A2R8YF78-1|DDX3X_HUMAN Computationally mapped isoform of ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=1 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41347465, "end_pos": 41334253, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000646122.1", "url": "https://www.ensembl.org/id/ENST00000646122.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000496222.1", "url": "https://www.ensembl.org/id/ENSP00000496222.1" } ] } }, { "isoform_ac": "A0A2R8YF89-1", "url": "", "sequence": { "sequence": "MFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSR", "length": 96, "header": "tr|A0A2R8YF89-1|A0A2R8YF89_HUMAN Computationally mapped isoform of DEAD-box helicase 3 X-linked OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=1 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41342540, "end_pos": 41336157, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000615313.5", "url": "https://www.ensembl.org/id/ENST00000615313.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000496257.1", "url": "https://www.ensembl.org/id/ENSP00000496257.1" } ] } }, { "isoform_ac": "A0A2R8YFR4-1", "url": "", "sequence": { "sequence": "MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASRRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN", "length": 660, "header": "tr|A0A2R8YFR4-1|A0A2R8YFR4_HUMAN Computationally mapped isoform of RNA helicase OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=1 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41347716, "end_pos": 41334253, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000644074.1", "url": "https://www.ensembl.org/id/ENST00000644074.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000496663.1", "url": "https://www.ensembl.org/id/ENSP00000496663.1" } ] } }, { "isoform_ac": "A0A2R8YFS5-1", "url": "", "sequence": { "sequence": "MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN", "length": 661, "header": "tr|A0A2R8YFS5-1|DDX3X_HUMAN Computationally mapped isoform of ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=1 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41347716, "end_pos": 41334253, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000646319.1", "url": "https://www.ensembl.org/id/ENST00000646319.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000495377.1", "url": "https://www.ensembl.org/id/ENSP00000495377.1" } ] } }, { "isoform_ac": "A0A2R8YGJ1-1", "url": "", "sequence": { "sequence": "XELFSGGNTGINFEKYDDIPVEATGNNCPPHIESCKSMLFLLSKRKET", "length": 48, "header": "tr|A0A2R8YGJ1-1|DDX3X_HUMAN Computationally mapped isoform of ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=1 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41343332, "end_pos": 41342737, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000647373.1", "url": "https://www.ensembl.org/id/ENST00000647373.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000496076.1", "url": "https://www.ensembl.org/id/ENSP00000496076.1" } ] } }, { "isoform_ac": "A0A2U3TZJ9-1", "url": "", "sequence": { "sequence": "MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASRRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN", "length": 661, "header": "tr|A0A2U3TZJ9-1|A0A2U3TZJ9_HUMAN Computationally mapped isoform of RNA helicase OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=1 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41347716, "end_pos": 41334253, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000399959.7", "url": "https://www.ensembl.org/id/ENST00000399959.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000382840.3", "url": "https://www.ensembl.org/id/ENSP00000382840.3" } ] } }, { "isoform_ac": "F6S8Q4-1", "url": "", "sequence": { "sequence": "MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN", "length": 629, "header": "tr|F6S8Q4-1|F6S8Q4_HUMAN Computationally mapped isoform of RNA helicase OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=1 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41347716, "end_pos": 41334253, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000441189.4", "url": "https://www.ensembl.org/id/ENST00000441189.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000414281.3", "url": "https://www.ensembl.org/id/ENSP00000414281.3" } ] } }, { "isoform_ac": "O00571-1", "url": "", "sequence": { "sequence": "MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN", "length": 662, "header": "sp|O00571-1|DDX3X_HUMAN Isoform 1 of ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=3 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41347716, "end_pos": 41334253, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000629496.3", "url": "https://www.ensembl.org/id/ENST00000629496.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000487224.1", "url": "https://www.ensembl.org/id/ENSP00000487224.1" } ] } }, { "isoform_ac": "O00571-2", "url": "", "sequence": { "sequence": "MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASSFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN", "length": 646, "header": "sp|O00571-2|DDX3X_HUMAN Isoform 2 of ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=3 CANONICAL=O00571-1" }, "locus": { "chromosome": "X", "start_pos": 41347716, "end_pos": 41334253, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000457138.7", "url": "https://www.ensembl.org/id/ENST00000457138.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000392494.2", "url": "https://www.ensembl.org/id/ENSP00000392494.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 114, "start_aa": "Ser", "end_pos": 114, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser114", "evidence": [ { "id": "O00571", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00571" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "30444036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30444036" }, { "id": "30397120", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30397120" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "26853435", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26853435" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "35083852", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35083852" }, { "id": "32870666", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32870666" }, { "id": "32119511", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32119511" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" }, { "id": "33465208", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33465208" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 204, "start_aa": "Thr", "end_pos": 204, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr204", "evidence": [ { "id": "O00571", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00571" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "30444036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30444036" }, { "id": "30397120", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30397120" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "26853435", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26853435" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "35083852", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35083852" }, { "id": "32870666", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32870666" }, { "id": "32119511", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32119511" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" }, { "id": "33465208", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33465208" }, { "id": "O00571", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O00571" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 584, "start_aa": "Ser", "end_pos": 584, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser584", "evidence": [ { "id": "O00571", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00571" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "30444036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30444036" }, { "id": "30397120", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30397120" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "26853435", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26853435" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "35083852", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35083852" }, { "id": "32870666", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32870666" }, { "id": "32119511", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32119511" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" }, { "id": "33465208", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33465208" }, { "id": "O00571", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O00571" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 588, "start_aa": "Ser", "end_pos": 588, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser588", "evidence": [ { "id": "O00571", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00571" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "30444036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30444036" }, { "id": "30397120", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30397120" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "26853435", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26853435" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "35083852", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35083852" }, { "id": "32870666", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32870666" }, { "id": "32119511", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32119511" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" }, { "id": "33465208", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33465208" }, { "id": "O00571", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O00571" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 611, "start_aa": "Ser", "end_pos": 611, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser611", "evidence": [ { "id": "O00571", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00571" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "30444036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30444036" }, { "id": "30397120", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30397120" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "26853435", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26853435" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "34019948", "database": "PubMed", "url": 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"relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 615, "start_aa": "Ser", "end_pos": 615, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser615", "evidence": [ { "id": "O00571", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O00571" }, { "id": "31373491", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31373491" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 616, "start_aa": "Ser", "end_pos": 616, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser616", "evidence": [ { "id": "O00571", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00571" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "30444036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30444036" }, { "id": "30397120", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30397120" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "26853435", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26853435" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "35083852", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35083852" }, { "id": "32870666", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32870666" }, { "id": "32119511", "database": 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Mol. Genet.", "date": "2004", "authors": "Ditton HJ, Zimmer J, Kamp C, Rajpert-De Meyts E, Vogt PH", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "reference": [ { "type": "PubMed", "id": "15294876", "url": "https://glygen.org/publication/PubMed/15294876" } ] }, { "title": "Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function.", "journal": "Cell", "date": "2004", "authors": "Yedavalli VS, Neuveut C, Chi YH, Kleiman L, Jeang KT", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "reference": [ { "type": "PubMed", "id": "15507209", "url": "https://glygen.org/publication/PubMed/15507209" } ] }, { "title": "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.", "journal": "Nat. Biotechnol.", "date": "2005", "authors": "Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ", "evidence": [ { "database": "UniProtKB", "id": "A0A2R8Y650", "url": "https://www.uniprot.org/uniprot/A0A2R8Y650" }, { "database": "iPTMnet", "id": "O00571-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00571-1" } ], "reference": [ { "type": "PubMed", "id": "15592455", "url": "https://glygen.org/publication/PubMed/15592455" } ] }, { "title": "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.", "journal": "Nature methods", "date": "2005", "authors": "Tao WA, Wollscheid B, O'Brien R, Eng JK, Li XJ, Bodenmiller B, Watts JD, Hood L, Aebersold R", "evidence": [ { "database": "iPTMnet", "id": "O00571-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00571-1" } ], "reference": [ { "type": "PubMed", "id": "16094384", "url": 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Biol.", "date": "2007", "authors": "H\u00f6gbom Martin, Collins Ruairi, van den Berg Susanne, Jenvert Rose-Marie, Karlberg Tobias, Kotenyova Tetyana, Flores Alex, Karlsson Hedestam Gunilla B, Schiavone Lovisa Holmberg", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "reference": [ { "type": "PubMed", "id": "17631897", "url": "https://glygen.org/publication/PubMed/17631897" } ] }, { "title": "Candidate tumor suppressor DDX3 RNA helicase specifically represses cap-dependent translation by acting as an eIF4E inhibitory protein.", "journal": "Oncogene", "date": "2008", "authors": "Shih JW, Tsai TY, Chao CH, Wu Lee YH", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "reference": [ { "type": "PubMed", "id": "17667941", "url": "https://glygen.org/publication/PubMed/17667941" } ] }, { "title": "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.", "journal": "Journal of proteome research", "date": "2007", "authors": "Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD", "evidence": [ { "database": "iPTMnet", "id": "O00571-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00571-1" } ], "reference": [ { "type": "PubMed", "id": "17924679", "url": "https://glygen.org/publication/PubMed/17924679" } ] }, { "title": "Hydrophilic interaction chromatography reduces the complexity of the phosphoproteome and improves global phosphopeptide isolation and detection.", "journal": "Molecular & cellular proteomics : MCP", "date": "2008", "authors": "McNulty DE, Annan RS", "evidence": [ { "database": "iPTMnet", "id": "O00571-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00571-1" } ], "reference": [ { "type": "PubMed", "id": "18212344", "url": "https://glygen.org/publication/PubMed/18212344" } ] }, { "title": "Oncogenic role of DDX3 in breast cancer biogenesis.", "journal": "Oncogene", "date": "2008-06-26", "authors": "Botlagunta M, Vesuna F, Mironchik Y, Raman A, Lisok A, Winnard P, Mukadam S, Van Diest P, Chen J H, Farabaugh P, Patel A H, Raman V", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "reference": [ { "type": "PubMed", "id": "18264132", "url": "https://glygen.org/publication/PubMed/18264132" } ] }, { "title": "The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response.", "journal": "The EMBO journal", "date": "2008", "authors": "Soulat D, Burckstummer T, Westermayer S, Goncalves A, Bauch A, Stefanovic A, Hantschel O, Bennett KL, Decker T, Superti-Furga G", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "iPTMnet", "id": "O00571", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O00571" } ], "reference": [ { "type": "PubMed", "id": "18583960", "url": "https://glygen.org/publication/PubMed/18583960" } ] }, { "title": "The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control.", "journal": "Molecular biology of the cell", "date": "2008", "authors": "Lai MC, Lee YH, Tarn WY", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "reference": [ { "type": "PubMed", "id": "18596238", "url": "https://glygen.org/publication/PubMed/18596238" } ] }, { "title": "Human DDX3 functions in translation and interacts with the translation initiation factor eIF3.", "journal": "Nucleic acids research", "date": "2008-08", "authors": "Lee Chung-Sheng, Dias Anusha P, Jedrychowski Mark, Patel Arvind H, Hsu Jeanne L, Reed Robin", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "reference": [ { "type": "PubMed", "id": "18628297", "url": "https://glygen.org/publication/PubMed/18628297" } ] }, { "title": "TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules.", "journal": "Hum. 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Genet.", "date": "2008", "authors": "Goulet I, Boisvenue S, Mokas S, Mazroui R, Cote J", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "reference": [ { "type": "PubMed", "id": "18632687", "url": "https://glygen.org/publication/PubMed/18632687" } ] }, { "title": "Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation.", "journal": "The EMBO journal", "date": "2008", "authors": "Schroder M, Baran M, Bowie AG", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "reference": [ { "type": "PubMed", "id": "18636090", "url": "https://glygen.org/publication/PubMed/18636090" } ] }, { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge 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"PubMed", "id": "29899501", "url": "https://glygen.org/publication/PubMed/29899501" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "O00571", "url": "https://oglcnac.org/atlas/detail/O00571" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "Investigating nucleo-cytoplasmic shuttling of the human DEAD-box helicase DDX3.", "journal": "European journal of cell biology", "date": "2018", "authors": "Brennan R, Haap-Hoff A, Gu L, Gautier V, Long A, Schroder M", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "reference": [ { "type": "PubMed", "id": "30131165", "url": 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translation for cellular homeostasis.", "journal": "Journal of biomedical science", "date": "2023-05-22", "authors": "Hung Yu-Wen, Ouyang Ching, Ping Xiaoli, Qi Yue, Wang Yi-Chang, Kung Hsing-Jien, Ann David K", "evidence": [ { "database": "O-GlcNAc Database", "id": "O00571", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00571" } ], "reference": [ { "type": "PubMed", "id": "37217939", "url": "https://glygen.org/publication/PubMed/37217939" } ] }, { "title": "Perturbation Analysis of a Prognostic DDX3X-Mediated Gene Expression Signature Identifies the Antimetastatic Potential of Chaetocin in Hepatocellular Carcinoma.", "journal": "Cells", "date": "2023-06-14", "authors": "Lin Tsung-Chieh", "evidence": [ { "database": "RefSeq", "id": "NP_001180345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180345" } ], "reference": [ { "type": "PubMed", "id": "37371098", "url": "https://glygen.org/publication/PubMed/37371098" } ] }, { "title": "ITPR1-AS1 promotes small cell lung cancer metastasis by facilitating P21HRAS splicing and stabilizing DDX3X to activate the cRaf-MEK-ERK cascade.", "journal": "Cancer letters", "date": "2023-11-28", "authors": "Zhang Quanli, Zheng Limin, Bai Yongkang, Su Chi, Che Yuru, Xu Jiawen, Sun Kemin, Ni Jie, Huang Lingli, Shen Ye, Jia Lili, Xu Lin, Yin Rong, Li Ming, Hu Jingwen", "evidence": [ { "database": "RefSeq", "id": "NP_001180345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180345" } ], "reference": [ { "type": "PubMed", "id": "37820992", "url": "https://glygen.org/publication/PubMed/37820992" } ] }, { "title": "Genetic and phenotypic findings in 34 novel Spanish patients with DDX3X neurodevelopmental disorder.", "journal": "Clinical genetics", "date": "2024-02", "authors": "Parra Alejandro, Pascual Patricia, Cazalla Mario, Arias Pedro, Gallego-Zazo Natalia, San-Mart\u00edn Esteban A, Silv\u00e1n Cristina, Santos-Simarro Fernando, , Nevado Juli\u00e1n, Tenorio-Castano Jair, Lapunzina Pablo", "evidence": [ { "database": "RefSeq", "id": "NP_001180345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180345" } ], "reference": [ { "type": "PubMed", "id": "37904618", "url": "https://glygen.org/publication/PubMed/37904618" } ] }, { "title": "Targeting of proteins to granule subsets is determined by timing and not by sorting: The specific granule protein NGAL is localized to azurophil granules when expressed in HL-60 cells.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1996", "authors": "Le Cabec V, Cowland JB, Calafat J, Borregaard N", "evidence": [ { "database": "Reactome", "id": "R-HSA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6798695" } ], "reference": [ { "type": "PubMed", "id": "8692836", "url": "https://glygen.org/publication/PubMed/8692836" } ] }, { "title": "Functional coherence of the human Y chromosome.", "journal": "Science", "date": "1997", "authors": "Lahn B T, Page D C", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "reference": [ { "type": "PubMed", "id": "9381176", "url": "https://glygen.org/publication/PubMed/9381176" } ] } ], "pathway": [ { "id": "hsa:1654", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:1654", "resource": "KEGG Pathway" }, { "id": "R-HSA-6798695", "name": "Neutrophil degranulation", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZN21-1", "protein_name": "DEAD-box helicase 3, Y-linked", "gene_name": "Ddx3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSHVAEEDELGLDQQLAGLDLTSPDSQSGASTASKGRYIPPHLRNREATKASYDKDSSRWSKDKDAYSSFGSRSDTRAKSSFFSDRGSGSRGRFDDRGRSDYEGVGSRGGRSGFGKFERGGNSRWCDKADEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYTDGPGEALRAMKENGKYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEEADKRSFLLDLLNATGKDSLILVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAFEHHYKGGSRGRSKSRFSGGFGARDYRQSSGASSSSFSSGRASNSRSGGGSHGSSRGFGGGSYGGFYNSDGYGGNYSSQGVDWWGN", "length": 659 }, "evidence": [ { "id": "45916506", "url": "http://www.informatics.jax.org/homology/45916506", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P16381-1", "protein_name": "Putative ATP-dependent RNA helicase Pl10", "gene_name": "D1Pas1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { 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"sequence": { "sequence": "MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRGDSRGKSSFFGDRGSGSRGRFDDRGRGDYDGIGGRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYADGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGAEIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEEIDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAFEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGGSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN", "length": 662 }, "evidence": [ { "id": "45916507", "url": "http://www.informatics.jax.org/homology/45916507", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 25, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "RNA helicase activity", "id": "GO:0003724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003724", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "transcription factor binding", "id": "GO:0008134", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008134", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "cadherin binding", "id": "GO:0045296", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045296", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "ribosomal small subunit binding", "id": "GO:0043024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043024", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "eukaryotic initiation factor 4E binding", "id": "GO:0008190", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008190", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "signaling adaptor activity", "id": "GO:0035591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035591", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activator activity", "id": "GO:0043539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043539", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "DNA helicase activity", "id": "GO:0003678", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003678", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "gamma-tubulin binding", "id": "GO:0043015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043015", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "poly(A) binding", "id": "GO:0008143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008143", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "ribonucleoside triphosphate phosphatase activity", "id": "GO:0017111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017111", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "RNA strand annealing activity", "id": "GO:0033592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033592", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "CTPase activity", "id": "GO:0043273", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043273", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "mRNA 5'-UTR binding", "id": "GO:0048027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048027", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "RNA stem-loop binding", "id": "GO:0035613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035613", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "translation initiation factor binding", "id": "GO:0031369", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031369", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "helicase activity", "id": "GO:0004386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004386", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 16, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "lamellipodium", "id": "GO:0030027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030027", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "cell leading edge", "id": "GO:0031252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031252", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "secretory granule lumen", "id": "GO:0034774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034774", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "ficolin-1-rich granule lumen", "id": "GO:1904813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904813", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "NLRP3 inflammasome complex", "id": "GO:0072559", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072559", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "cytoplasmic stress granule", "id": "GO:0010494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010494", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "P granule", "id": "GO:0043186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043186", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 49, "go_terms": [ { "name": "positive regulation of interferon-alpha production", "id": "GO:0032727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032727", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "protein localization to cytoplasmic stress granule", "id": "GO:1903608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903608", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "positive regulation of protein acetylation", "id": "GO:1901985", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901985", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "chromosome segregation", "id": "GO:0007059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007059", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "positive regulation of cell growth", "id": "GO:0030307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030307", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "positive regulation of cysteine-type endopeptidase activity involved in apoptotic process", "id": "GO:0043280", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043280", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "lipid homeostasis", "id": "GO:0055088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055088", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "positive regulation of non-canonical NF-kappaB signal transduction", "id": "GO:1901224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901224", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "negative regulation of cysteine-type endopeptidase activity involved in apoptotic process", "id": "GO:0043154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043154", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "response to virus", "id": "GO:0009615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009615", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "translational initiation", "id": "GO:0006413", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006413", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "negative regulation of cell growth", "id": "GO:0030308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030308", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "negative regulation of non-canonical NF-kappaB signal transduction", "id": "GO:1901223", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901223", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "positive regulation of protein serine/threonine kinase activity", "id": "GO:0071902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071902", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "negative regulation of translation", "id": "GO:0017148", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017148", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "negative regulation of protein-containing complex assembly", "id": "GO:0031333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031333", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "positive regulation of translation", "id": "GO:0045727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045727", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "positive regulation of G1/S transition of mitotic cell cycle", "id": "GO:1900087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900087", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "positive regulation of canonical Wnt signaling pathway", "id": "GO:0090263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090263", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "intrinsic apoptotic signaling pathway", "id": "GO:0097193", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097193", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "RNA secondary structure unwinding", "id": "GO:0010501", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010501", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "cellular response to virus", "id": "GO:0098586", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098586", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "negative regulation of extrinsic apoptotic signaling pathway via death domain receptors", "id": "GO:1902042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902042", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "extrinsic apoptotic signaling pathway via death domain receptors", "id": "GO:0008625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008625", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "stress granule assembly", "id": "GO:0034063", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034063", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "negative regulation of intrinsic apoptotic signaling pathway", "id": "GO:2001243", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001243", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "positive regulation of protein autophosphorylation", "id": "GO:0031954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031954", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "positive regulation of type I interferon production", "id": "GO:0032481", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032481", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "positive regulation of toll-like receptor 7 signaling pathway", "id": "GO:0034157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034157", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "positive regulation of chemokine (C-C motif) ligand 5 production", "id": "GO:0071651", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071651", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "positive regulation of translation in response to endoplasmic reticulum stress", "id": "GO:0036493", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036493", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "positive regulation of viral genome replication", "id": "GO:0045070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045070", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "positive regulation of NLRP3 inflammasome complex assembly", "id": "GO:1900227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900227", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "positive regulation of translational initiation", "id": "GO:0045948", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045948", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "cytosolic ribosome assembly", "id": "GO:0042256", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042256", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "positive regulation of protein K63-linked ubiquitination", "id": "GO:1902523", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902523", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "positive regulation of interferon-beta production", "id": "GO:0032728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032728", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "cellular response to osmotic stress", "id": "GO:0071470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071470", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "gamete generation", "id": "GO:0007276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007276", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "cellular response to arsenic-containing substance", "id": "GO:0071243", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071243", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" }, { "name": "positive regulation of toll-like receptor 8 signaling pathway", "id": "GO:0034161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034161", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 22, "end_pos": 24, "annotation": "n_glycosylation_sequon" }, { "start_pos": 26, "end_pos": 28, "annotation": "n_glycosylation_sequon" }, { "start_pos": 414, "end_pos": 416, "annotation": "n_glycosylation_sequon" }, { "start_pos": 436, "end_pos": 438, "annotation": "n_glycosylation_sequon" }, { "start_pos": 551, "end_pos": 553, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Phosphorylated by TBK1; the phosphorylation is required for the synergistic induction of IFNB mediated by TBK1 and DDX3X (PubMed:18583960). Phosphorylated by IKBKE at Ser-102 after ssRNA viral infection; enhances the induction of INFB promoter by IRF3 (PubMed:18583960, PubMed:23478265). The cytoplasmic form is highly phosphorylated in the G1/S phase of the cell cycle and much less at G2/M (PubMed:22034099). Phosphorylation by CSNK1E may inhibit RNA-stimulated ATPase activity (PubMed:29222110).", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "22034099", "url": "https://glygen.org/publication/PubMed/22034099" }, { "database": "PubMed", "id": "18583960", "url": "https://glygen.org/publication/PubMed/18583960" }, { "database": "PubMed", "id": "23478265", "url": "https://glygen.org/publication/PubMed/23478265" }, { "database": "PubMed", "id": "29222110", "url": "https://glygen.org/publication/PubMed/29222110" } ] }, { "annotation": "Upon stimulation of death receptors, including TNFRSF10B, recruited to receptors and cleaved by caspases. Proteolytic fragments remain associated with the receptors. This cleavage presumably inactivates DDX3X anti-apoptotic function.", "evidence": [ { "database": "UniProtKB", "id": "O00571", "url": "https://www.uniprot.org/uniprot/O00571" }, { "database": "PubMed", "id": "18846110", "url": "https://glygen.org/publication/PubMed/18846110" } ] } ], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + H(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZD32-1", "A0A8I5ZKX7-1", "D4A7Q5-1", "D4A523-1", "Q3MHU3-1", "Q6AYJ1-1", "F1M298-1", "Q5RJZ1-1", "P60123-1", "Q793F9-1", "F1LPQ2-1", "G3V681-1", "D4ACP5-1", "F1LNJ2-1", "D4A2Z8-1", "Q6P3V8-1", "Q5RKI1-1", "A0A0G2K0E0-1", "G3V9M1-1", "P70486-1", "Q66HG7-1", "Q99PT0-1", "D3ZG52-1", "Q4G005-1", "Q5BJS0-1", "Q64060-1", "Q9JIX5-1", "P06761-1", "Q5U216-1", "Q62780-1", "Q641Y8-1", "Q5XI69-1", "Q63413-1", "Q1HG60-1", "D3ZA12-1", "D3Z9Z9-1", "Q68G38-1", "Q6GX84-1", "Q9QUL6-1", 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"Q03532-1", "Q03940-1", "Q12464-1", "P06634-1", "P06839-1", "P07271-1", "P0CS90-1", "P10081-1", "P11484-1", "P12954-1", "P24784-1", "P25694-1", "P29469-1", "P32597-1", "P32644-1", "P53131-1", "P60010-1", "Q04437-1", "Q05931-1", "Q06218-1", "P30665-1", "P30771-1", "P31380-1", "P32580-1", "P32639-1", "P32794-1", "P32807-1", "P32892-1", "P0CX15-1", "P0CX21-1", "P34243-1", "O13559-1", "P0CX14-1", "P0CX20-1", "P36120-1", "P53978-1", "Q00578-1", "P38712-1", "P38766-1", "P40024-1", "P40150-1", "P40562-1", "P45818-1", "P51979-1", "P53115-1", "P53166-1", "P53327-1", "Q04217-1", "P36009-1", "Q05471-1", "P36016-1", "P38112-1", "P38719-1", "P40352-1", "P47047-1", "P53091-1", "P53734-1", "Q12389-1", "P38086-1", "Q05549-1", "Q07478-1", "Q12039-1", "Q12099-1", "Q12697-1", "P43538-1", "P0CX22-1", "P40105-1", "P40434-1", "P40889-1", "P53819-1", "Q03099-1", "Q06698-1", "Q07888-1", "Q99208-1", "Q08995-1", "Q3E7X8-1", "P17119-1", "P90529-1", "Q869Z1-1", "Q54KG8-1", "Q55F84-1", "Q54DN9-1", "Q54HE9-1", 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"Q9V3K3-1", "Q9VF26-1", "Q9VH07-1", "Q9VL52-1", "P49735-1", "Q9V461-1", "Q9VGW6-1", "Q9VDY1-1", "Q7K3M5-1", "P09052-1", "Q9VN03-1", "Q9W484-1", "Q9VGI8-1", "Q9VHS8-1", "Q9VUV9-1", "Q9VYS3-1", "Q9VSE2-1", "Q9VIF6-1", "Q9VVK8-1", "Q9V3C4-1", "O61305-1", "Q9VX34-1", "Q9VRI0-1", "Q9VJ74-1", "Q6NQY9-1", "Q9W3Y5-1", "Q7KU24-1", "Q02870-1", "Q07886-1", "Q23976-1", "Q27268-1", "Q9V3C0-1", "Q9VHP0-1", "Q9VHU1-1", "Q9VNV3-1", "Q9VQN8-1", "P24785-1", "P46461-1", "P54351-1", "Q86B47-1", "A8DZ26-1", "P19109-1", "P29844-1", "Q9V433-1", "Q7KVP9-1", "A1Z9L3-1", "O16102-1", "O97159-1", "Q9XYU0-1", "Q9XYU1-1", "Q9I7M8-1", "Q9VL25-1", "Q9VY54-1", "Q8SWT2-1", "Q8IRL9-1", "Q8ING5-1", "Q8SY39-1", "Q9VPT3-1", "P10987-1", "P10981-1", "P20480-1", "Q9VQR3-1", "P53501-1", "P02572-1", "P83967-1", "P02574-1", "Q9VIZ3-1", "Q9VL76-1", "Q9VDA0-1", "Q9W4W2-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] }, { "id": "R-HSA-6798748", "name": "Exocytosis of secretory granule lumen proteins", "equation": "", "summary": "Secretory vesicles provide a reservoir of secreted proteins and membrane-associated receptors that are required at the earliest stages of the neutrophil-mediated inflammatory response. They are mobilized in response to a wide variety of inflammatory stimuli (Sengelov et al. 1993a,b). Resultant cell surface changes allow the neutrophil to establish firm contact with activated vascular epithelium (Faurschou & Borregaard 2003).", "cellular_location": "extracellular region, secretory granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P18669-1", "Q13464-1", "P32320-1", "P09917-1", "O00487-1", "P13639-1", "P12268-1", "P62937-1", "Q96G03-1", "P68402-1", "Q99436-1", "P55072-1", "P68104-1", "P11142-1", "Q9Y315-1", "P13010-1", "P04075-1", "P09972-1", "P07900-1", "P09769-1", "P09211-1", "Q16539-1", "P14618-1", "P07741-1", "Q01432-1", "P12956-1", "Q7Z6Z7-1", "Q9UNP9-1", "P14174-1", "P04040-1", "O00571-1", "P06744-1", "P52790-1", "P11678-1", "P00491-1", "P06737-1", "P00746-1", "Q13162-1", "P17858-1", "P46976-1", "P22392-1", "P13716-1", "O75874-1", "P20839-1", "O00764-1" ], "evidence": [ { "id": "R-HSA-6798748", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6798748" } ] }, { "id": "R-HSA-6800434", "name": "Exocytosis of ficolin-rich granule lumen proteins", "equation": "", "summary": "Ficoli-1 rich granules are a relatively new fourth neutrophil granule population that is enriched in the microbial lectin ficolin-1. Ficolin-1 is present in tertiary granules, but ficolin-1 rich granules can be differentiated by having low levels of gelatinases and an elevated exocytosis propensity (Rorvig et al. 2009, 2013). The importance of these granules may be to provide rapid release of pattern recognition molecules to activate the lectin complement pathway (Rorvig et al. 2009).", "cellular_location": "extracellular region, ficolin-1-rich granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9UBR2-1", "P18669-1", "P32320-1", "P09917-1", "O00487-1", "P13639-1", "P12268-1", "P62937-1", "P15586-1", "Q96G03-1", "Q9P0J7-1", "P68402-1", "P36871-1", "Q99436-1", "P07339-1", "P13798-1", "P53396-1", "P55072-1", "P68104-1", "P11142-1", "Q9Y315-1", "P04075-1", "P09972-1", "P07900-1", "P09211-1", "Q16539-1", "P07858-1", "P14618-1", "P28482-1", "Q01432-1", "P12956-1", "Q7Z6Z7-1", "Q9UNP9-1", "Q13510-1", "P14174-1", "P15848-1", "P16278-1", "Q8WVQ1-1", "P04040-1", "O00571-1", "P14780-1", "P06744-1", "P52790-1", "P00491-1", "P06737-1", "Q16769-1", "P08236-1", "P02794-1", "P07384-1", "Q14004-1", "P00746-1", "P98066-1", "P25774-1", "Q13162-1", "P17858-1", "P46976-1", "P09960-1", "P22392-1", "P13716-1", "O75874-1", "P20839-1" ], "evidence": [ { "id": "R-HSA-6800434", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6800434" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A096MJV7", "gene_name": "Chd9", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A096MJV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A096MJV7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A096MJV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A096MJV7" } ] } ] }, { "uniprot_ac": "A0A0G2JTM6", "gene_name": "Dhx35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A0G2JTM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JTM6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0G2JTM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JTM6" } ] } ] }, { "uniprot_ac": "A0A0G2K0E0", "gene_name": "Ddx56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A0G2K0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K0E0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0G2K0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K0E0" } ] } ] }, { "uniprot_ac": "A0A0G2K0H9", "gene_name": "Ruvbl1-ps1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A0G2K0H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K0H9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A0G2K0H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K0H9" } ] } ] }, { "uniprot_ac": "A0A0G2K283", "gene_name": "Dhx8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A0G2K283", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K283" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0G2K283", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K283" } ] } ] }, { "uniprot_ac": "A0A0G2K4S4", "gene_name": "Ddx51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A0G2K4S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K4S4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0G2K4S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K4S4" } ] } ] }, { "uniprot_ac": "A0A0G2KA92", "gene_name": "Chd2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A0G2KA92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2KA92" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A0G2KA92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2KA92" } ] } ] }, { "uniprot_ac": "A0A7N9VSG0", "gene_name": "Afg2b", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A7N9VSG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A7N9VSG0" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A0A7N9VSG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A7N9VSG0" } ] } ] }, { "uniprot_ac": "A0A8I5ZKH1", "gene_name": "Ythdc2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I5ZKH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZKH1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A8I5ZKH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZKH1" } ] } ] }, { "uniprot_ac": "A0A8I5ZKV9", "gene_name": "Ddx5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I5ZKV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZKV9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A8I5ZKV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZKV9" } ] } ] }, { "uniprot_ac": "A0A8I5ZKX7", "gene_name": "Ddx47", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I5ZKX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZKX7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A8I5ZKX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZKX7" } ] } ] }, { "uniprot_ac": "A0A8I5ZZZ0", "gene_name": "Ddx31", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I5ZZZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZZZ0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A8I5ZZZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZZZ0" } ] } ] }, { "uniprot_ac": "A0A8I6ABZ7", "gene_name": "Dhx9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I6ABZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6ABZ7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A8I6ABZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6ABZ7" } ] } ] }, { "uniprot_ac": "A0A8I6AFW4", "gene_name": "Ddx24", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I6AFW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AFW4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A8I6AFW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AFW4" } ] } ] }, { "uniprot_ac": "A0A8I6AK63", "gene_name": "ENSRNOG00000069014", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I6AK63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AK63" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A8I6AK63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AK63" } ] } ] }, { "uniprot_ac": "A0A8I6GF11", "gene_name": "Eif4a1-ps8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I6GF11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GF11" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A8I6GF11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GF11" } ] } ] }, { "uniprot_ac": "A0A8I6GIN4", "gene_name": "AC129365.1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I6GIN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GIN4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A8I6GIN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GIN4" } ] } ] }, { "uniprot_ac": "A0A8I6GIY0", "gene_name": "Chd3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I6GIY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GIY0" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A8I6GIY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GIY0" } ] } ] }, { "uniprot_ac": "A1Z9L3", "gene_name": "pea", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A1Z9L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1Z9L3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A1Z9L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1Z9L3" } ] } ] }, { "uniprot_ac": "A2A4P0", "gene_name": "Dhx8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A2A4P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A4P0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A2A4P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A4P0" } ] } ] }, { "uniprot_ac": "A2A8L1", "gene_name": "Chd5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A2A8L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A8L1" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A2A8L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A8L1" } ] } ] }, { "uniprot_ac": "A2ACQ1", "gene_name": "Dhx35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A2ACQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ACQ1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A2ACQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ACQ1" } ] } ] }, { "uniprot_ac": "A2AJK6", "gene_name": "Chd7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A2AJK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AJK6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A2AJK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AJK6" } ] } ] }, { "uniprot_ac": "A2PYH4", "gene_name": "HFM1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A2PYH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2PYH4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A2PYH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2PYH4" } ] } ] }, { "uniprot_ac": "A3KFM7", "gene_name": "Chd6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A3KFM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A3KFM7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A3KFM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A3KFM7" } ] } ] }, { "uniprot_ac": "A6KSS8", "gene_name": "Mcm7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A6KSS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6KSS8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6KSS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6KSS8" } ] } ] }, { "uniprot_ac": "A6NHR9", "gene_name": "SMCHD1", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "A6NHR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NHR9" } ] } ] }, { "uniprot_ac": "A8DZ26", "gene_name": "anne", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A8DZ26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A8DZ26" } ] } ] }, { "uniprot_ac": "A8MPP1", "gene_name": "DDX11L8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A8MPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A8MPP1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A8MPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A8MPP1" } ] } ] }, { "uniprot_ac": "B0G0Y4", "gene_name": "wrn", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "B0G0Y4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G0Y4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "B0G0Y4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G0Y4" } ] } ] }, { "uniprot_ac": "B1AR17", "gene_name": "Chd3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "B1AR17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1AR17" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "B1AR17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1AR17" } ] } ] }, { "uniprot_ac": "B2GUX3", "gene_name": "Mcm5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "B2GUX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GUX3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "B2GUX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GUX3" } ] } ] }, { "uniprot_ac": "B2RR83", "gene_name": "Ythdc2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "B2RR83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RR83" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "B2RR83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RR83" } ] } ] }, { "uniprot_ac": "D3Z0M9", "gene_name": "Ddx23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3Z0M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z0M9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3Z0M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z0M9" } ] } ] }, { "uniprot_ac": "D3Z4R1", "gene_name": "Hfm1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3Z4R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z4R1" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3Z4R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z4R1" } ] } ] }, { "uniprot_ac": "D3Z9Z9", "gene_name": "Smarcad1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3Z9Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9Z9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3Z9Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9Z9" } ] } ] }, { "uniprot_ac": "D3ZA12", "gene_name": "Chd6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZA12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZA12" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZA12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZA12" } ] } ] }, { "uniprot_ac": "D3ZAP7", "gene_name": "Chd7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZAP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZAP7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZAP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZAP7" } ] } ] }, { "uniprot_ac": "D3ZBY5", "gene_name": "Ddx10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZBY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBY5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZBY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBY5" } ] } ] }, { "uniprot_ac": "D3ZD32", "gene_name": "Chd5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZD32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD32" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZD32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD32" } ] } ] }, { "uniprot_ac": "D3ZD46", "gene_name": "Dhx58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZD46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD46" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZD46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD46" } ] } ] }, { "uniprot_ac": "D3ZD97", "gene_name": "Dhx15", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZD97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD97" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZD97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD97" } ] } ] }, { "uniprot_ac": "D3ZEG9", "gene_name": "Ercc2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZEG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEG9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZEG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEG9" } ] } ] }, { "uniprot_ac": "D3ZFP4", "gene_name": "Mcm3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZFP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZFP4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZFP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZFP4" } ] } ] }, { "uniprot_ac": "D3ZG52", "gene_name": "Dna2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "D3ZG52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZG52" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZG52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZG52" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZG52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZG52" } ] } ] }, { "uniprot_ac": "D3ZH42", "gene_name": "Mov10l1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZH42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZH42" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZH42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZH42" } ] } ] }, { "uniprot_ac": "D3ZHW0", "gene_name": "Dhx29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZHW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZHW0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZHW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZHW0" } ] } ] }, { "uniprot_ac": "D3ZP96", "gene_name": "Mcm2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZP96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZP96" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZP96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZP96" } ] } ] }, { "uniprot_ac": "D3ZQW1", "gene_name": "Blm", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZQW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQW1" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZQW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQW1" } ] } ] }, { "uniprot_ac": "D3ZSV6", "gene_name": "Dhx33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZSV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSV6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZSV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSV6" } ] } ] }, { "uniprot_ac": "D3ZUC2", "gene_name": "Mov10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZUC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZUC2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZUC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZUC2" } ] } ] }, { "uniprot_ac": "D3ZVK1", "gene_name": "Mcm8", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZVK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZVK1" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZVK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZVK1" } ] } ] }, { "uniprot_ac": "D3ZX56", "gene_name": "Ddx55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZX56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZX56" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZX56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZX56" } ] } ] }, { "uniprot_ac": "D4A1R0", "gene_name": "Dhx37", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A1R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1R0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4A1R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1R0" } ] } ] }, { "uniprot_ac": "D4A2B7", "gene_name": "Afg2b", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A2B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2B7" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "D4A2B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2B7" } ] } ] }, { "uniprot_ac": "D4A2Z8", "gene_name": "Dhx36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2Z8" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2Z8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2Z8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2Z8" } ] } ] }, { "uniprot_ac": "D4A321", "gene_name": "Dhx38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A321" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4A321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A321" } ] } ] }, { "uniprot_ac": "D4A523", "gene_name": "Nlrp3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "D4A523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A523" } ] } ] }, { "uniprot_ac": "D4A6Q6", "gene_name": "Ino80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "D4A6Q6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A6Q6" } ] } ] }, { "uniprot_ac": "D4A7Q5", "gene_name": "Ddx28", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A7Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A7Q5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4A7Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A7Q5" } ] } ] }, { "uniprot_ac": "D4AAG9", "gene_name": "Chd1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4AAG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AAG9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D4AAG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AAG9" } ] } ] }, { "uniprot_ac": "D4ACP5", "gene_name": "Recql5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4ACP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ACP5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D4ACP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ACP5" } ] } ] }, { "uniprot_ac": "D4ADT5", "gene_name": "Rig1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4ADT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADT5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4ADT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADT5" } ] } ] }, { "uniprot_ac": "E9PU01", "gene_name": "Chd4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "E9PU01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PU01" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E9PU01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PU01" } ] } ] }, { "uniprot_ac": "E9PZJ8", "gene_name": "Ascc3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "E9PZJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PZJ8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E9PZJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PZJ8" } ] } ] }, { "uniprot_ac": "E9PZM4", "gene_name": "Chd2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "E9PZM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PZM4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E9PZM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PZM4" } ] } ] }, { "uniprot_ac": "E9Q555", "gene_name": "Rnf213", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] }, { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] } ] }, { "uniprot_ac": "E9QAM5", "gene_name": "Helz2", "activity": [ { "ec_number": "3.1.13.1", "activity": "Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.", "evidence": [ { "id": "E9QAM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9QAM5" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "E9QAM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9QAM5" } ] }, { "ec_number": "3.1.13.1", "activity": "", "evidence": [ { "id": "E9QAM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9QAM5" } ] } ] }, { "uniprot_ac": "F1LNJ2", "gene_name": "Snrnp200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1LNJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LNJ2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1LNJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LNJ2" } ] } ] }, { "uniprot_ac": "F1LPQ2", "gene_name": "Ascc3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1LPQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LPQ2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1LPQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LPQ2" } ] } ] }, { "uniprot_ac": "F1LTH9", "gene_name": "Wrn", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1LTH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LTH9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1LTH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LTH9" } ] } ] }, { "uniprot_ac": "F1LTR3", "gene_name": "Tdrd12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1LTR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LTR3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1LTR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LTR3" } ] } ] }, { "uniprot_ac": "F1LWY1", "gene_name": "Hfm1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1LWY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LWY1" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1LWY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LWY1" } ] } ] }, { "uniprot_ac": "F1M298", "gene_name": "Fbh1", "activity": [ { "ec_number": "5.6.2.4", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.", "evidence": [ { "id": "F1M298", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M298" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1M298", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M298" } ] } ] }, { "uniprot_ac": "F1M5F3", "gene_name": "Mcm9", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1M5F3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M5F3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1M5F3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M5F3" } ] } ] }, { "uniprot_ac": "F1M9L4", "gene_name": "Atp13a4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1M9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M9L4" } ] } ] }, { "uniprot_ac": "F1MA70", "gene_name": "Atp13a5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1MA70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1MA70" } ] } ] }, { "uniprot_ac": "F8VPZ5", "gene_name": "Ercc6", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F8VPZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F8VPZ5" } ] } ] }, { "uniprot_ac": "G3V681", "gene_name": "Mcm4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "G3V681", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V681" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "G3V681", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V681" } ] } ] }, { "uniprot_ac": "G3V6W5", "gene_name": "Ifih1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "G3V6W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6W5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3V6W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6W5" } ] } ] }, { "uniprot_ac": "G3V8T5", "gene_name": "Ruvbl2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "G3V8T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V8T5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "G3V8T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V8T5" } ] } ] }, { "uniprot_ac": "G3V9M1", "gene_name": "Ddx23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "G3V9M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9M1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3V9M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9M1" } ] } ] }, { "uniprot_ac": "G3X8X0", "gene_name": "Dhx16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "G3X8X0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3X8X0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3X8X0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3X8X0" } ] } ] }, { "uniprot_ac": "O00148", "gene_name": "DDX39A", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O00148", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00148" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O00148", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00148" } ] } ] }, { "uniprot_ac": "O00487", "gene_name": "PSMD14", "activity": [ { "ec_number": "3.4.19.-", "activity": "", "evidence": [ { "id": "O00487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00487" } ] } ] }, { "uniprot_ac": "O00571", "gene_name": "DDX3X", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O00571", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00571" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O00571", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00571" } ] } ] }, { "uniprot_ac": "O00764", "gene_name": "PDXK", "activity": [ { "ec_number": "2.7.1.35", "activity": "ATP + pyridoxal = ADP + H(+) + pyridoxal 5'-phosphate.", "evidence": [ { "id": "O00764", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00764" } ] }, { "ec_number": "2.7.1.35", "activity": "", "evidence": [ { "id": "O00764", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00764" } ] } ] }, { "uniprot_ac": "O00835", "gene_name": "repB", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O00835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00835" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O00835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00835" } ] } ] }, { "uniprot_ac": "O08811", "gene_name": "Ercc2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O08811", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08811" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O08811", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08811" } ] } ] }, { "uniprot_ac": "O09053", "gene_name": "Wrn", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O09053", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09053" } ] }, { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "O09053", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09053" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O09053", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09053" } ] } ] }, { "uniprot_ac": "O13559", "gene_name": "YRF1-4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O13559", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O13559" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O13559", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O13559" } ] } ] }, { "uniprot_ac": "O14646", "gene_name": "CHD1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O14646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14646" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O14646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14646" } ] } ] }, { "uniprot_ac": "O14647", "gene_name": "CHD2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O14647", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14647" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O14647", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14647" } ] } ] }, { "uniprot_ac": "O14656", "gene_name": "TOR1A", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "O14656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14656" } ] } ] }, { "uniprot_ac": "O14657", "gene_name": "TOR1B", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "O14657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14657" } ] } ] }, { "uniprot_ac": "O15523", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O15523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15523" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O15523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15523" } ] } ] }, { "uniprot_ac": "O16102", "gene_name": "Chd3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O16102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O16102" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O16102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O16102" } ] } ] }, { "uniprot_ac": "O35286", "gene_name": "Dhx15", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O35286", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35286" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O35286", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35286" } ] } ] }, { "uniprot_ac": "O43143", "gene_name": "DHX15", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O43143", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43143" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O43143", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43143" } ] } ] }, { "uniprot_ac": "O43933", "gene_name": "PEX1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "O43933", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43933" } ] } ] }, { "uniprot_ac": "O46072", "gene_name": "kz", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O46072", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O46072" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O46072", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O46072" } ] } ] }, { "uniprot_ac": "O60231", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O60231", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60231" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O60231", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60231" } ] } ] }, { "uniprot_ac": "O60282", "gene_name": "KIF5C", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "O60282", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60282" } ] } ] }, { "uniprot_ac": "O60306", "gene_name": "AQR", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O60306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60306" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O60306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60306" } ] } ] }, { "uniprot_ac": "O61305", "gene_name": "Dbp80", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O61305", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61305" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O61305", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61305" } ] } ] }, { "uniprot_ac": "O70133", "gene_name": "Dhx9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O70133", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70133" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O70133", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70133" } ] } ] }, { "uniprot_ac": "O75351", "gene_name": "VPS4B", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O75351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75351" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "O75351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75351" } ] } ] }, { "uniprot_ac": "O75417", "gene_name": "POLQ", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O75417", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75417" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O75417", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75417" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O75417", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75417" } ] } ] }, { "uniprot_ac": "O75643", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O75643", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75643" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O75643", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75643" } ] } ] }, { "uniprot_ac": "O75874", "gene_name": "IDH1", "activity": [ { "ec_number": "1.1.1.42", "activity": "D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH.", "evidence": [ { "id": "O75874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75874" } ] }, { "ec_number": "1.1.1.42", "activity": "", "evidence": [ { "id": "O75874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75874" } ] } ] }, { "uniprot_ac": "O88700", "gene_name": "Blm", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O88700", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88700" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O88700", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88700" } ] } ] }, { "uniprot_ac": "O94761", "gene_name": "RECQL4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O94761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94761" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O94761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94761" } ] } ] }, { "uniprot_ac": "O94762", "gene_name": "RECQL5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O94762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94762" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O94762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94762" } ] } ] }, { "uniprot_ac": "O95786", "gene_name": "RIGI", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O95786", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95786" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O95786", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95786" } ] } ] }, { "uniprot_ac": "O97159", "gene_name": "Mi-2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O97159", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O97159" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O97159", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O97159" } ] } ] }, { "uniprot_ac": "P00491", "gene_name": "PNP", "activity": [ { "ec_number": "2.4.2.1", "activity": "a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase.", "evidence": [ { "id": "P00491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00491" } ] }, { "ec_number": "2.4.2.1", "activity": "", "evidence": [ { "id": "P00491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00491" } ] } ] }, { "uniprot_ac": "P00746", "gene_name": "CFD", "activity": [ { "ec_number": "3.4.21.46", "activity": "Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.", "evidence": [ { "id": "P00746", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00746" } ] }, { "ec_number": "3.4.21.46", "activity": "", "evidence": [ { "id": "P00746", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00746" } ] } ] }, { "uniprot_ac": "P02572", "gene_name": "Act42A", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P02572", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P02572" } ] } ] }, { "uniprot_ac": "P02574", "gene_name": "Act79B", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P02574", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P02574" } ] } ] }, { "uniprot_ac": "P02794", "gene_name": "FTH1", "activity": [ { "ec_number": "1.16.3.1", "activity": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O.", "evidence": [ { "id": "P02794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P02794" } ] }, { "ec_number": "1.16.3.1", "activity": "", "evidence": [ { "id": "P02794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P02794" } ] } ] }, { "uniprot_ac": "P04040", "gene_name": "CAT", "activity": [ { "ec_number": "1.11.1.6", "activity": "2 H2O2 = 2 H2O + O2.", "evidence": [ { "id": "P04040", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04040" } ] }, { "ec_number": "1.11.1.6", "activity": "", "evidence": [ { "id": "P04040", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04040" } ] } ] }, { "uniprot_ac": "P04075", "gene_name": "ALDOA", "activity": [ { "ec_number": "4.1.2.13", "activity": "beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate.", "evidence": [ { "id": "P04075", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04075" } ] }, { "ec_number": "4.1.2.13", "activity": "", "evidence": [ { "id": "P04075", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04075" } ] } ] }, { "uniprot_ac": "P05186", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P05186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05186" } ] }, { "ec_number": "3.9.1.1", "activity": "H2O + N-phosphocreatine = creatine + phosphate.", "evidence": [ { "id": "P05186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05186" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P05186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05186" } ] }, { "ec_number": "3.9.1.1", "activity": "", "evidence": [ { "id": "P05186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05186" } ] } ] }, { "uniprot_ac": "P06634", "gene_name": "DED1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P06634", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06634" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P06634", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06634" } ] } ] }, { "uniprot_ac": "P06737", "gene_name": "PYGL", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "P06737", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06737" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "P06737", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06737" } ] } ] }, { "uniprot_ac": "P06744", "gene_name": "GPI", "activity": [ { "ec_number": "5.3.1.9", "activity": "alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate.", "evidence": [ { "id": "P06744", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06744" } ] }, { "ec_number": "5.3.1.9", "activity": "", "evidence": [ { "id": "P06744", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06744" } ] } ] }, { "uniprot_ac": "P06761", "gene_name": "Hspa5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P06761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06761" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P06761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06761" } ] } ] }, { "uniprot_ac": "P06839", "gene_name": "RAD3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P06839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06839" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P06839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06839" } ] } ] }, { "uniprot_ac": "P07271", "gene_name": "PIF1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P07271", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07271" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P07271", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07271" } ] } ] }, { "uniprot_ac": "P07339", "gene_name": "CTSD", "activity": [ { "ec_number": "3.4.23.5", "activity": "Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.", "evidence": [ { "id": "P07339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07339" } ] }, { "ec_number": "3.4.23.5", "activity": "", "evidence": [ { "id": "P07339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07339" } ] } ] }, { "uniprot_ac": "P07384", "gene_name": "CAPN1", "activity": [ { "ec_number": "3.4.22.52", "activity": "Broad endopeptidase specificity.", "evidence": [ { "id": "P07384", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07384" } ] }, { "ec_number": "3.4.22.52", "activity": "", "evidence": [ { "id": "P07384", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07384" } ] } ] }, { "uniprot_ac": "P07741", "gene_name": "APRT", "activity": [ { "ec_number": "2.4.2.7", "activity": "AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine.", "evidence": [ { "id": "P07741", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07741" } ] }, { "ec_number": "2.4.2.7", "activity": "", "evidence": [ { "id": "P07741", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07741" } ] } ] }, { "uniprot_ac": "P07828", "gene_name": "act18", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P07828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07828" } ] } ] }, { "uniprot_ac": "P07829", "gene_name": "act3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P07829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07829" } ] } ] }, { "uniprot_ac": "P07830", "gene_name": "act19", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P07830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07830" } ] } ] }, { "uniprot_ac": "P07858", "gene_name": "CTSB", "activity": [ { "ec_number": "3.4.22.1", "activity": "Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.", "evidence": [ { "id": "P07858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07858" } ] }, { "ec_number": "3.4.22.1", "activity": "", "evidence": [ { "id": "P07858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07858" } ] } ] }, { "uniprot_ac": "P07900", "gene_name": "HSP90AA1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P07900", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07900" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P07900", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07900" } ] } ] }, { "uniprot_ac": "P07901", "gene_name": "Hsp90aa1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P07901", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07901" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P07901", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07901" } ] } ] }, { "uniprot_ac": "P08236", "gene_name": "GUSB", "activity": [ { "ec_number": "3.2.1.31", "activity": "a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate.", "evidence": [ { "id": "P08236", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08236" } ] }, { "ec_number": "3.2.1.31", "activity": "", "evidence": [ { "id": "P08236", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08236" } ] } ] }, { "uniprot_ac": "P08289", "gene_name": "Alpl", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P08289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08289" } ] }, { "ec_number": "3.9.1.1", "activity": "H2O + N-phosphocreatine = creatine + phosphate.", "evidence": [ { "id": "P08289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08289" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P08289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08289" } ] } ] }, { "uniprot_ac": "P09052", "gene_name": "vas", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P09052", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09052" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P09052", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09052" } ] } ] }, { "uniprot_ac": "P09211", "gene_name": "GSTP1", "activity": [ { "ec_number": "2.5.1.18", "activity": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+).", "evidence": [ { "id": "P09211", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09211" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "P09211", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09211" } ] } ] }, { "uniprot_ac": "P09242", "gene_name": "Alpl", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09242" } ] }, { "ec_number": "3.9.1.1", "activity": "H2O + N-phosphocreatine = creatine + phosphate.", "evidence": [ { "id": "P09242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09242" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09242" } ] }, { "ec_number": "3.9.1.1", "activity": "", "evidence": [ { "id": "P09242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09242" } ] } ] }, { "uniprot_ac": "P09769", "gene_name": "FGR", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09769", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09769" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P09769", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09769" } ] } ] }, { "uniprot_ac": "P09917", "gene_name": "ALOX5", "activity": [ { "ec_number": "1.13.11.-", "activity": "", "evidence": [ { "id": "P09917", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09917" } ] }, { "ec_number": "1.13.11.34", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = H2O + leukotriene A4.", "evidence": [ { "id": "P09917", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09917" } ] } ] }, { "uniprot_ac": "P09960", "gene_name": "LTA4H", "activity": [ { "ec_number": "3.3.2.6", "activity": "H2O + leukotriene A4 = leukotriene B4.", "evidence": [ { "id": "P09960", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09960" } ] }, { "ec_number": "3.4.11.4", "activity": "Release of the N-terminal residue from a tripeptide.", "evidence": [ { "id": "P09960", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09960" } ] }, { "ec_number": "3.3.2.6", "activity": "", "evidence": [ { "id": "P09960", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09960" } ] } ] }, { "uniprot_ac": "P09972", "gene_name": "ALDOC", "activity": [ { "ec_number": "4.1.2.13", "activity": "beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate.", "evidence": [ { "id": "P09972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09972" } ] }, { "ec_number": "4.1.2.13", "activity": "", "evidence": [ { "id": "P09972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09972" } ] } ] }, { "uniprot_ac": "P0CS90", "gene_name": "SSC1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P0CS90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CS90" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P0CS90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CS90" } ] } ] }, { "uniprot_ac": "P0CX14", "gene_name": "YRF1-3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P0CX14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX14" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P0CX14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX14" } ] } ] }, { "uniprot_ac": "P0CX15", "gene_name": "YRF1-7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P0CX15", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX15" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P0CX15", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX15" } ] } ] }, { "uniprot_ac": "P0CX20", "gene_name": "YRF1-1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P0CX20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX20" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P0CX20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX20" } ] } ] }, { "uniprot_ac": "P0CX21", "gene_name": "YRF1-5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P0CX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX21" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P0CX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX21" } ] } ] }, { "uniprot_ac": "P0CX22", "gene_name": "YRF1-8", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P0CX22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX22" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P0CX22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX22" } ] } ] }, { "uniprot_ac": "P10081", "gene_name": "TIF1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P10081", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10081" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P10081", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10081" } ] } ] }, { "uniprot_ac": "P10630", "gene_name": "Eif4a2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P10630", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10630" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P10630", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10630" } ] } ] }, { "uniprot_ac": "P10981", "gene_name": "Act87E", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P10981", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10981" } ] } ] }, { "uniprot_ac": "P10987", "gene_name": "Act5C", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P10987", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10987" } ] } ] }, { "uniprot_ac": "P11021", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P11021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11021" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P11021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11021" } ] } ] }, { "uniprot_ac": "P11142", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P11142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11142" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P11142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11142" } ] } ] }, { "uniprot_ac": "P11484", "gene_name": "SSB1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P11484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11484" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P11484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11484" } ] } ] }, { "uniprot_ac": "P11678", "gene_name": "EPX", "activity": [ { "ec_number": "1.11.1.7", "activity": "2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O.", "evidence": [ { "id": "P11678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11678" } ] }, { "ec_number": "1.11.1.7", "activity": "", "evidence": [ { "id": "P11678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11678" } ] } ] }, { "uniprot_ac": "P12268", "gene_name": "IMPDH2", "activity": [ { "ec_number": "1.1.1.205", "activity": "H2O + IMP + NAD(+) = H(+) + NADH + XMP.", "evidence": [ { "id": "P12268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12268" } ] }, { "ec_number": "1.1.1.205", "activity": "", "evidence": [ { "id": "P12268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12268" } ] } ] }, { "uniprot_ac": "P12954", "gene_name": "SRS2", "activity": [ { "ec_number": "5.6.2.4", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.", "evidence": [ { "id": "P12954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12954" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "P12954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12954" } ] } ] }, { "uniprot_ac": "P12956", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.-", "activity": "", "evidence": [ { "id": "P12956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12956" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P12956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12956" } ] } ] }, { "uniprot_ac": "P13010", "gene_name": "XRCC5", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P13010", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13010" } ] } ] }, { "uniprot_ac": "P13639", "gene_name": "EEF2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P13639", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13639" } ] } ] }, { "uniprot_ac": "P13716", "gene_name": "ALAD", "activity": [ { "ec_number": "4.2.1.24", "activity": "2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen.", "evidence": [ { "id": "P13716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13716" } ] }, { "ec_number": "4.2.1.24", "activity": "", "evidence": [ { "id": "P13716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13716" } ] } ] }, { "uniprot_ac": "P13798", "gene_name": "APEH", "activity": [ { "ec_number": "3.4.19.1", "activity": "Internal cleavage of oxidized and glycated proteins.", "evidence": [ { "id": "P13798", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13798" } ] }, { "ec_number": "3.4.19.1", "activity": "", "evidence": [ { "id": "P13798", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13798" } ] } ] }, { "uniprot_ac": "P14174", "gene_name": "MIF", "activity": [ { "ec_number": "5.3.2.1", "activity": "3-phenylpyruvate = enol-phenylpyruvate.", "evidence": [ { "id": "P14174", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14174" } ] }, { "ec_number": "5.3.3.12", "activity": "L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.", "evidence": [ { "id": "P14174", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14174" } ] }, { "ec_number": "5.3.2.1", "activity": "", "evidence": [ { "id": "P14174", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14174" } ] } ] }, { "uniprot_ac": "P14618", "gene_name": "PKM", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] } ] }, { "uniprot_ac": "P14780", "gene_name": "MMP9", "activity": [ { "ec_number": "3.4.24.35", "activity": "Cleavage of gelatin types I and V and collagen types IV and V.", "evidence": [ { "id": "P14780", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14780" } ] }, { "ec_number": "3.4.24.35", "activity": "", "evidence": [ { "id": "P14780", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14780" } ] } ] }, { "uniprot_ac": "P15424", "gene_name": "MSS116", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P15424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15424" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P15424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15424" } ] } ] }, { "uniprot_ac": "P15586", "gene_name": "GNS", "activity": [ { "ec_number": "3.1.6.14", "activity": "Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.", "evidence": [ { "id": "P15586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15586" } ] }, { "ec_number": "3.1.6.14", "activity": "", "evidence": [ { "id": "P15586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15586" } ] } ] }, { "uniprot_ac": "P15848", "gene_name": "ARSB", "activity": [ { "ec_number": "3.1.6.12", "activity": "Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate.", "evidence": [ { "id": "P15848", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15848" } ] }, { "ec_number": "3.1.6.12", "activity": "", "evidence": [ { "id": "P15848", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15848" } ] } ] }, { "uniprot_ac": "P15938", "gene_name": "PRP16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P15938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15938" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P15938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15938" } ] } ] }, { "uniprot_ac": "P16278", "gene_name": "GLB1", "activity": [ { "ec_number": "3.2.1.23", "activity": "Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.", "evidence": [ { "id": "P16278", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16278" } ] }, { "ec_number": "3.2.1.23", "activity": "", "evidence": [ { "id": "P16278", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16278" } ] } ] }, { "uniprot_ac": "P16381", "gene_name": "D1Pas1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P16381", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16381" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P16381", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16381" } ] } ] }, { "uniprot_ac": "P16474", "gene_name": "KAR2", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P16474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16474" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P16474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16474" } ] } ] }, { "uniprot_ac": "P16521", "gene_name": "YEF3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P16521", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16521" } ] } ] }, { "uniprot_ac": "P17119", "gene_name": "KAR3", "activity": [ { "ec_number": "5.6.1.4", "activity": "ATP + H2O + a kinesin associated with a microtubule at position (n) = ADP + phosphate + a kinesin associated with a microtubule at position (n-1, toward the minus end).", "evidence": [ { "id": "P17119", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17119" } ] }, { "ec_number": "5.6.1.4", "activity": "", "evidence": [ { "id": "P17119", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17119" } ] } ] }, { "uniprot_ac": "P17844", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P17844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17844" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P17844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17844" } ] } ] }, { "uniprot_ac": "P17858", "gene_name": "PFKL", "activity": [ { "ec_number": "2.7.1.11", "activity": "ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+).", "evidence": [ { "id": "P17858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17858" } ] }, { "ec_number": "2.7.1.11", "activity": "", "evidence": [ { "id": "P17858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17858" } ] } ] }, { "uniprot_ac": "P18074", "gene_name": "ERCC2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P18074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18074" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P18074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18074" } ] } ] }, { "uniprot_ac": "P18669", "gene_name": "PGAM1", "activity": [ { "ec_number": "5.4.2.11", "activity": "(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate.", "evidence": [ { "id": "P18669", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18669" } ] }, { "ec_number": "5.4.2.4", "activity": "(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+).", "evidence": [ { "id": "P18669", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18669" } ] }, { "ec_number": "5.4.2.4", "activity": "", "evidence": [ { "id": "P18669", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18669" } ] }, { "ec_number": "5.4.2.11", "activity": "", "evidence": [ { "id": "P18669", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18669" } ] } ] }, { "uniprot_ac": "P19109", "gene_name": "Rm62", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P19109", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19109" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P19109", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19109" } ] } ] }, { "uniprot_ac": "P19447", "gene_name": "ERCC3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P19447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19447" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P19447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19447" } ] } ] }, { "uniprot_ac": "P20029", "gene_name": "Hspa5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P20029", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20029" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P20029", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20029" } ] } ] }, { "uniprot_ac": "P20095", "gene_name": "PRP2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P20095", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20095" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P20095", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20095" } ] } ] }, { "uniprot_ac": "P20447", "gene_name": "DBP3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P20447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20447" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P20447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20447" } ] } ] }, { "uniprot_ac": "P20448", "gene_name": "HCA4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P20448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20448" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P20448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20448" } ] } ] }, { "uniprot_ac": "P20449", "gene_name": "DBP5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P20449", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20449" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P20449", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20449" } ] } ] }, { "uniprot_ac": "P20480", "gene_name": "ncd", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P20480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20480" } ] } ] }, { "uniprot_ac": "P20839", "gene_name": "IMPDH1", "activity": [ { "ec_number": "1.1.1.205", "activity": "H2O + IMP + NAD(+) = H(+) + NADH + XMP.", "evidence": [ { "id": "P20839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20839" } ] }, { "ec_number": "1.1.1.205", "activity": "", "evidence": [ { "id": "P20839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20839" } ] } ] }, { "uniprot_ac": "P21372", "gene_name": "PRP5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P21372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21372" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P21372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21372" } ] } ] }, { "uniprot_ac": "P22392", "gene_name": "NME2", "activity": [ { "ec_number": "2.7.4.6", "activity": "a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP.", "evidence": [ { "id": "P22392", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22392" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P22392", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22392" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P22392", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22392" } ] }, { "ec_number": "2.7.13.3", "activity": "", "evidence": [ { "id": "P22392", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22392" } ] } ] }, { "uniprot_ac": "P22516", "gene_name": "CHL1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P22516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22516" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P22516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22516" } ] } ] }, { "uniprot_ac": "P23128", "gene_name": "me31B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P23128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23128" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P23128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23128" } ] } ] }, { "uniprot_ac": "P23249", "gene_name": "Mov10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P23249", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23249" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P23249", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23249" } ] } ] }, { "uniprot_ac": "P23394", "gene_name": "PRP28", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P23394", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23394" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P23394", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23394" } ] } ] }, { "uniprot_ac": "P24004", "gene_name": "PEX1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P24004", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24004" } ] } ] }, { "uniprot_ac": "P24279", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P24279", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24279" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P24279", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24279" } ] } ] }, { "uniprot_ac": "P24384", "gene_name": "PRP22", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P24384", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24384" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P24384", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24384" } ] } ] }, { "uniprot_ac": "P24783", "gene_name": "DBP2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P24783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24783" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P24783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24783" } ] } ] }, { "uniprot_ac": "P24784", "gene_name": "DBP1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P24784", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24784" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P24784", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24784" } ] } ] }, { "uniprot_ac": "P24785", "gene_name": "mle", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P24785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24785" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P24785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24785" } ] } ] }, { "uniprot_ac": "P25205", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P25205", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25205" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P25205", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25205" } ] } ] }, { "uniprot_ac": "P25206", "gene_name": "Mcm3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P25206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25206" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P25206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25206" } ] } ] }, { "uniprot_ac": "P25439", "gene_name": "brm", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P25439", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25439" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P25439", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25439" } ] } ] }, { "uniprot_ac": "P25694", "gene_name": "CDC48", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P25694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25694" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "P25694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25694" } ] } ] }, { "uniprot_ac": "P25774", "gene_name": "CTSS", "activity": [ { "ec_number": "3.4.22.27", "activity": "Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.", "evidence": [ { "id": "P25774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25774" } ] }, { "ec_number": "3.4.22.27", "activity": "", "evidence": [ { "id": "P25774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25774" } ] } ] }, { "uniprot_ac": "P25808", "gene_name": "SPB4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P25808", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25808" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P25808", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25808" } ] } ] }, { "uniprot_ac": "P26196", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P26196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26196" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P26196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26196" } ] } ] }, { "uniprot_ac": "P26802", "gene_name": "Dbp73D", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P26802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26802" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P26802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26802" } ] } ] }, { "uniprot_ac": "P28482", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P28482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28482" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P28482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28482" } ] } ] }, { "uniprot_ac": "P28738", "gene_name": "Kif5c", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P28738", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28738" } ] } ] }, { "uniprot_ac": "P29469", "gene_name": "MCM2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P29469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29469" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P29469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29469" } ] } ] }, { "uniprot_ac": "P29496", "gene_name": "MCM5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P29496", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29496" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P29496", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29496" } ] } ] }, { "uniprot_ac": "P29844", "gene_name": "Hsc70-3", "activity": [ { "ec_number": "3.6.1.3", "activity": "", "evidence": [ { "id": "P29844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29844" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P29844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29844" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P29844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29844" } ] } ] }, { "uniprot_ac": "P30665", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P30665", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30665" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P30665", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30665" } ] } ] }, { "uniprot_ac": "P30771", "gene_name": "NAM7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P30771", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30771" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P30771", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30771" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P30771", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30771" } ] }, { "ec_number": "3.6.4.12", "activity": 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phosphate.", "evidence": [ { "id": "P46459", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46459" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "P46459", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46459" } ] } ] }, { "uniprot_ac": "P46460", "gene_name": "Nsf", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P46460", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46460" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "P46460", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46460" } ] } ] }, { "uniprot_ac": "P46461", "gene_name": "comt", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P46461", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46461" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { 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"2.4.1.186", "activity": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP.", "evidence": [ { "id": "P46976", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46976" } ] }, { "ec_number": "2.4.1.186", "activity": "", "evidence": [ { "id": "P46976", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46976" } ] } ] }, { "uniprot_ac": "P47047", "gene_name": "MTR4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P47047", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47047" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P47047", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47047" } ] } ] }, { "uniprot_ac": "P49135", "gene_name": "Ercc3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": 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"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate.", "evidence": [ { "id": "P49961", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49961" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "P49961", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49961" } ] } ] }, { "uniprot_ac": "P51530", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "P51530", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51530" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P51530", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51530" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P51530", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51530" } ] } ] }, { "uniprot_ac": "P51979", "gene_name": 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{ "id": "Q07888", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07888" } ] } ] }, { "uniprot_ac": "Q08211", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q08211", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08211" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q08211", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08211" } ] } ] }, { "uniprot_ac": "Q08995", "gene_name": "", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q08995", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08995" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q08995", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08995" } ] } ] }, { "uniprot_ac": "Q09XV5", "gene_name": "Chd8", "activity": [ { "ec_number": 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"url": "https://www.uniprot.org/uniprot/Q13838" } ] } ] }, { "uniprot_ac": "Q14004", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q14004", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14004" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q14004", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14004" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q14004", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14004" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q14004", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14004" } ] } ] }, { "uniprot_ac": "Q14147", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", 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