{ "uniprot_canonical_ac": "O00468-1", "uniprot_ac": "O00468", "uniprot_id": "AGRIN_HUMAN", "mass": { "chemical_mass": 217320.0, "monoisotopic_mass": 217320.0 }, "refseq": { "ac": "NP_940978", "name": "agrin isoform 2 precursor", "summary": "This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940978" }, "gene_names": [ { "name": "AGRN", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O00468", "id": "O00468" }, { "name": "AGRIN; CMS8; CMSPPD", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940978", "id": "NP_940978" }, { "name": "AGRIN", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O00468", "id": "O00468" }, { "name": "AGRN", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940978", "id": "NP_940978" } ], "protein_names": [ { "name": "Agrin", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O00468" }, { "name": "agrin isoform 2 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940978", "id": "NP_940978" }, { "name": "agrin proteoglycan", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940978", "id": "NP_940978" } ], "function": [ { "annotation": "AGRN promotes lung adenocarcinoma progression by activating Notch signaling pathway and acts as a therapeutic target.", "evidence": [ { "database": "RefSeq", "id": "NP_940978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940978" }, { "database": "PubMed", "id": "37321467", "url": "https://glygen.org/publication/PubMed/37321467" } ] }, { "annotation": "Association between the 110-kDa C-terminal agrin fragment and skeletal muscle decline among community-dwelling older women.", "evidence": [ { "database": "RefSeq", "id": "NP_940978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940978" }, { "database": "PubMed", "id": "37562951", "url": "https://glygen.org/publication/PubMed/37562951" } ] }, { "annotation": "Bioinformatics-based analysis of the roles of basement membrane-related gene AGRN in systemic lupus erythematosus and pan-cancer development. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_940978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940978" }, { "database": "PubMed", "id": "37841281", "url": "https://glygen.org/publication/PubMed/37841281" } ] }, { "annotation": "Genes encoding agrin (AGRN) and neurotrypsin (PRSS12) are associated with muscle mass, strength and plasma C-terminal agrin fragment concentration.", "evidence": [ { "database": "RefSeq", "id": "NP_940978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940978" }, { "database": "PubMed", "id": "36609795", "url": "https://glygen.org/publication/PubMed/36609795" } ] }, { "annotation": "Heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic processing. Modulates calcium ion homeostasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha(3)-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This secreted isoform forms a bridge, after release from motor neurons, to basal lamina through binding laminin via the NtA domain.", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468#function" } ] }, { "annotation": "Is involved in regulation of neurite outgrowth probably due to the presence of the glycosaminoglcan (GAG) side chains of heparan and chondroitin sulfate attached to the Ser/Thr- and Gly/Ser-rich regions. Also involved in modulation of growth factor signaling (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468#function" }, { "database": "PubMed", "id": "19631309", "url": "https://glygen.org/publication/PubMed/19631309" }, { "database": "PubMed", "id": "21969364", "url": "https://glygen.org/publication/PubMed/21969364" } ] }, { "annotation": "Isoform 1, isoform 4 and isoform 5: neuron-specific (z+) isoforms that contain C-terminal insertions of 8-19 AA are potent activators of AChR clustering. Isoform 5, agrin (z+8), containing the 8-AA insert, forms a receptor complex in myotubules containing the neuronal AGRN, the muscle-specific kinase MUSK and LRP4, a member of the LDL receptor family. The splicing factors, NOVA1 and NOVA2, regulate AGRN splicing and production of the 'z' isoforms.", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468#function" } ] }, { "annotation": "Isoform 3 and isoform 6: lack any 'z' insert, are muscle-specific and may be involved in endothelial cell differentiation.", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468#function" } ] }, { "annotation": "The collagen ColQ binds to LRP4 and regulates the activation of the Muscle-Specific Kinase-LRP4 receptor complex by agrin at the neuromuscular junction.", "evidence": [ { "database": "RefSeq", "id": "NP_940978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940978" }, { "database": "PubMed", "id": "37356721", "url": "https://glygen.org/publication/PubMed/37356721" } ] }, { "annotation": "This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015].", "evidence": [ { "database": "RefSeq", "id": "NP_940978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940978" } ] }, { "annotation": "This released fragment is important for agrin signaling and to exert a maximal dendritic filopodia-inducing effect. All 'z' splice variants (z+) of this fragment also show an increase in the number of filopodia.", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468#function" } ] }, { "annotation": "Transmembrane form that is the predominate form in neurons of the brain, induces dendritic filopodia and synapse formation in mature hippocampal neurons in large part due to the attached glycosaminoglycan chains and the action of Rho-family GTPases.", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468#function" } ] } ], "disease": [ { "disease_id": "DOID:0110657", "recommended_name": { "id": "DOID:0110657", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110657", "name": "congenital myasthenic syndrome 8", "description": "A congenital myasthenic syndrome characterized by autosomal recessive inheritance of prominent defects of both the pre- and postsynaptic regions and muscle weakness that has_material_basis_in homozygous or compound heterozygous mutation in the AGRN gene on chromosome 1p." }, "synonyms": [ { "id": "DOID:0110657", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110657", "name": "congenital myasthenic syndrome 8 with pre- and postsynaptic defects", "description": "" }, { "id": "DOID:0110657", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110657", "name": "CMS8", "description": "" }, { "id": "DOID:0110657", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110657", "name": "congenital myasthenic syndrome due to agrin deficiency", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "congenital myasthenic syndrome 8", "description": "Any congenital myasthenic syndrome in which the cause of the disease is a mutation in the AGRN gene." }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "AGRN congenital myasthenic syndrome", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "CMS8", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "congenital myasthenic syndrome 8", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "congenital myasthenic syndrome 8 with pre- and postsynaptic defects", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "congenital myasthenic syndrome caused by mutation in AGRN", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "congenital myasthenic syndrome due to agrin deficiency", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "congenital myasthenic syndrome type 8", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "myasthenic syndrome, congenital, 8, with pre- and postsynaptic defects", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "myasthenic syndrome, congenital, type 8", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "myasthenic syndrome, congenital, 8", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "myasthenic syndrome, congenital, due to agrin deficiency", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "myasthenic syndrome, congenital, with Pre- and postsynaptic defects", "description": "" }, { "id": "MIM:615120", "resource": "MIM", "url": "https://www.omim.org/entry/615120", "name": "Myasthenic syndrome, congenital, 8", "description": "Myasthenic syndrome, congenital, 8" } ], "evidence": [ { "id": "615120", "database": "MIM", "url": "https://www.omim.org/entry/615120" } ] } ], "snv": [ { "evidence": [ { "id": "rs375197922", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs375197922" }, { "id": "rs375197922", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs375197922" }, { "id": "rs375197922", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs375197922#frequency_tab" }, { "id": "rs375197922", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs375197922" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 1034, "end_pos": 1034, "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->I).", "chr_id": "1", "chr_pos": "1047453", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T1034", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs375197922", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs375197922" }, { "id": "rs375197922", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs375197922" }, { "id": "rs375197922", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs375197922#frequency_tab" }, { "id": "rs375197922", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs375197922" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 1034, "end_pos": 1034, "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->N).", "chr_id": "1", "chr_pos": "1047453", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T1034", "disease": [ { "disease_id": "DOID:0110657", "recommended_name": { "id": "DOID:0110657", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110657", "name": "congenital myasthenic syndrome 8", "description": "A congenital myasthenic syndrome characterized by autosomal recessive inheritance of prominent defects of both the pre- and postsynaptic regions and muscle weakness that has_material_basis_in homozygous or compound heterozygous mutation in the AGRN gene on chromosome 1p." }, "synonyms": [ { "id": "DOID:0110657", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110657", "name": "congenital myasthenic syndrome 8 with pre- and postsynaptic defects", "description": "" }, { "id": "DOID:0110657", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110657", "name": "CMS8", "description": "" }, { "id": "DOID:0110657", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110657", "name": "congenital myasthenic syndrome due to agrin deficiency", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "congenital myasthenic syndrome 8", "description": "Any congenital myasthenic syndrome in which the cause of the disease is a mutation in the AGRN gene." }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "AGRN congenital myasthenic syndrome", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "CMS8", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "congenital myasthenic syndrome 8", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "congenital myasthenic syndrome 8 with pre- and postsynaptic defects", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "congenital myasthenic syndrome caused by mutation in AGRN", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "congenital myasthenic syndrome due to agrin deficiency", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "congenital myasthenic syndrome type 8", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "myasthenic syndrome, congenital, 8, with pre- and postsynaptic defects", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "myasthenic syndrome, congenital, type 8", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "myasthenic syndrome, congenital, 8", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "myasthenic syndrome, congenital, due to agrin deficiency", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "myasthenic syndrome, congenital, with Pre- and postsynaptic defects", "description": "" }, { "id": "MIM:615120", "resource": "MIM", "url": "https://www.omim.org/entry/615120", "name": "Myasthenic syndrome, congenital, 8", "description": "Myasthenic syndrome, congenital, 8" } ] } ], "keywords": [ "ebi", "germline", "disease" ] }, { "evidence": [ { "id": "rs74443982", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs74443982" }, { "id": "rs74443982", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs74443982#frequency_tab" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 1306, "end_pos": 1306, "sequence_org": "T", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->A).", "chr_id": "1", "chr_pos": "1049267", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T1306", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs758948924", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs758948924" }, { "id": "rs758948924", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs758948924" }, { "id": "rs758948924", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs758948924#frequency_tab" }, { "id": "rs758948924", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs758948924" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 162, "end_pos": 162, "sequence_org": "T", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->A).", "chr_id": "1", "chr_pos": "1041244", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T162", "disease": [ { "disease_id": "DOID:0110657", "recommended_name": { "id": "DOID:0110657", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110657", "name": "congenital myasthenic syndrome 8", "description": "A congenital myasthenic syndrome characterized by autosomal recessive inheritance of prominent defects of both the pre- and postsynaptic regions and muscle weakness that has_material_basis_in homozygous or compound heterozygous mutation in the AGRN gene on chromosome 1p." }, "synonyms": [ { "id": "DOID:0110657", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110657", "name": "congenital myasthenic syndrome 8 with pre- and postsynaptic defects", "description": "" }, { "id": "DOID:0110657", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110657", "name": "CMS8", "description": "" }, { "id": "DOID:0110657", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110657", "name": "congenital myasthenic syndrome due to agrin deficiency", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "congenital myasthenic syndrome 8", "description": "Any congenital myasthenic syndrome in which the cause of the disease is a mutation in the AGRN gene." }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "AGRN congenital myasthenic syndrome", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "CMS8", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "congenital myasthenic syndrome 8", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "congenital myasthenic syndrome 8 with pre- and postsynaptic defects", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "congenital myasthenic syndrome caused by mutation in AGRN", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "congenital myasthenic syndrome due to agrin deficiency", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "congenital myasthenic syndrome type 8", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "myasthenic syndrome, congenital, 8, with pre- and postsynaptic defects", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "myasthenic syndrome, congenital, type 8", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", "name": "myasthenic syndrome, congenital, 8", "description": "" }, { "id": "MONDO:0014052", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014052", 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O00468", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00468" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00468" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "O00468", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00468" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", 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"https://www.reactome.org/PathwayBrowser/#R-HSA-3656253", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-419037", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-419037", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-4420332", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4420332", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9820960", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9820960", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9833110", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833110", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_940978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940978", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "O00468", "url": "DISABLED", "database": "UniCarbKB", "categories": [ "Glycoproteomics" ] }, { "id": "A0A087X208", "url": "https://www.uniprot.org/uniprot/A0A087X208", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A087X208-1", "url": "https://www.uniprot.org/uniprot/A0A087X208-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494C0G5", "url": "https://www.uniprot.org/uniprot/A0A494C0G5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494C0G5-1", "url": "https://www.uniprot.org/uniprot/A0A494C0G5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494C1I6", "url": "https://www.uniprot.org/uniprot/A0A494C1I6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494C1I6-1", "url": "https://www.uniprot.org/uniprot/A0A494C1I6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00468-1", "url": "https://www.uniprot.org/uniprot/O00468-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00468-2", "url": "https://www.uniprot.org/uniprot/O00468-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00468-3", "url": "https://www.uniprot.org/uniprot/O00468-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00468-4", "url": "https://www.uniprot.org/uniprot/O00468-4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00468-5", "url": "https://www.uniprot.org/uniprot/O00468-5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00468-6", "url": "https://www.uniprot.org/uniprot/O00468-6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00468-7", "url": "https://www.uniprot.org/uniprot/O00468-7", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGRSHPGPLRPLLPLLVVAACVLPGAGGTCPERALERREEEANVVLTGTVEEILNVDPVQHTYSCKVRVWRYLKGKDLVARESLLDGGNKVVISGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNELMLNSSLMRITLRNLEEVEFCVEDKPGTHFTPVPPTPPDACRGMLCGFGAVCEPNAEGPGRASCVCKKSPCPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSADGLTASCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQGALPDPSRSCRVNPRTRRPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQCQGRDQCPEPCRFNAVCLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQCAFGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPCDRCGQCRFGALCEAETGRCVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASAGPCETCGDAVCAFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPCEQAECGSGGSGSGEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGACRGPTFAPLPPVAPLHCAQTPYGCCQDNITAARGVGLAGCPSACQCNPHGSYGGTCDPATGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCSCDPQGAVRDDCEQMTGLCSCKPGVAGPKCGQCPDGRALGPAGCEADASAPATCAEMRCEFGARCVEESGSAHCVCPMLTCPEANATKVCGSDGVTYGNECQLKTIACRQGLQISIQSLGPCQEAVAPSTHPTSASVTVTTPGLLLSQALPAPPGALPLAPSSTAHSQTTPPPSSRPRTTASVPRTTVWPVLTVPPTAPSPAPSLVASAFGESGSTDGSSDEELSGDQEASGGGSGGLEPLEGSSVATPGPPVERASCYNSALGCCSDGKTPSLDAEGSNCPATKVFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFRSVRLRDLGPGKSVRAIVDVHFDPTTAFRAPDVARALLRQIQVSRRRSLGVRRPLQEHVRFMDFDWFPAFITGATSGAIAAGATARATTASRLPSSAVTPRAPHPSHTSQPVAKTTAAPTTRRPPTTAPSRVPGRRPPAPQQPPKPCDSQPCFHGGTCQDWALGGGFTCSCPAGRGGAVCEKVLGAPVPAFEGRSFLAFPTLRAYHTLRLALEFRALEPQGLLLYNGNARGKDFLALALLDGRVQLRFDTGSGPAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALERTFVGAGLRGCIRLLDVNNQRLELGIGPGAATRGSGVGECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPTCADEKSPCQPNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTASGQDGSGPFLADFNGFSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRLEFRYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPKSRKVPHTVLNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHPCTRASGHPCLNGASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESELANEIPVPETLDSGALHSEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLGSQPVVLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLLEDAVTKPELRPCPTP", "length": 2068, "header": "sp|O00468-1|AGRIN_HUMAN Isoform 1 of Agrin OS=Homo sapiens OX=9606 GN=AGRN PE=1 SV=6 CANONICAL=O00468-1" }, "isoforms": [ { "isoform_ac": "A0A087X208-1", "url": "", "sequence": { "sequence": "MRITLRNLEEVEFCVEDKPGTHFTPVPPTPPDACRGMLCGFGAVCEPNAEGPGRASCVCKKSPCPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSADGLTASCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQGALPDPSRSCRVNPRTRRPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQCQGRDQCPEPCRFNAVCLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQCAFGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPCDRCGQCRFGALCEAETGRCVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASAGPCETCGDAVCAFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPCEQAECGSGGSGSGEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGACRGPTFAPLPPVAPLHCAQTPYGCCQDNITAARGVGLAGCPSACQCNPHGSYGGTCDPATGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCSCDPQGAVRDDCEQMTGLCSCKPGVAGPKCGQCPDGRALGPAGCEADASAPATCAEMRCEFGARCVEESGSAHCVCPMLTCPEANATKVCGSDGVTYGNECQLKTIACRQGLQISIQSLGPCQEAVAPSTHPTSASVTVTTPGLLLSQALPAPPGALPLAPSSTAHSQTTPPPSSRPRTTASVPRTTVWPVLTVPPTAPSPAPSLVASAFGESGSTDGSSDEELSGDQEASGGGSGGLEPLEGSSVATPGPPVERASCYNSALGCCSDGKTPSLDAEGSNCPATKVFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFRSVRLRDLGPGKSVRAIVDVHFDPTTAFRAPDVARALLRQIQVSRRRSLGVRRPLQEHVRFMDFDWFPAFITGATSGAIAAGATARATTASRLPSSAVTPRAPHPSHTSQPVAKTTAAPTTRRPPTTAPSRVPGRRPPAPQQPPKPCDSQPCFHGGTCQDWALGGGFTCSCPAGRGGAVCEKVLGAPVPAFEGRSFLAFPTLRAYHTLRLALEFRALEPQGLLLYNGNARGKDFLALALLDGRVQLRFDTGSGPAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALERTFVGAGLRGCIRLLDVNNQRLELGIGPGAATRGSGVGECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPTCADEKSPCQPNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTASGQDGSGPFLADFNGFSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRLEFRYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPKSRKVPHTVLNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHPCTRASGHPCLNGASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESELANEIPVPETLDSGALHSEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLGSQPVVLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLLEDAVTKPELRPCPTP", "length": 1930, "header": "tr|A0A087X208-1|A0A087X208_HUMAN Computationally mapped isoform of Agrin OS=Homo sapiens OX=9606 GN=AGRN PE=1 SV=1 CANONICAL=O00468-1" }, "locus": { "chromosome": "1", "start_pos": 1054978, "end_pos": 1022414, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000620552.4", "url": "https://www.ensembl.org/id/ENST00000620552.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000484607.1", "url": "https://www.ensembl.org/id/ENSP00000484607.1" } ] } }, { "isoform_ac": "A0A494C0G5-1", "url": "", "sequence": { "sequence": "MPPLPLARDTRQPPGASLLVRGFMVPCNACLILLATATLGFAVLLFLNNYKPGTHFTPVPPTPPDACRGMLCGFGAVCEPNAEGPGRASCVCKKSPCPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSADGLTASCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQGALPDPSRSCRVNPRTRRPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQCQGRDQCPEPCRFNAVCLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQCAFGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPCDRCGQCRFGALCEAETGRCVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASAGPCETCGDAVCAFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPCEQAECGSGGSGSGEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGACRGPTFAPLPPVAPLHCAQTPYGCCQDNITAARGVGLAGCPSACQCNPHGSYGGTCDPATGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCSCDPQGAVRDDCEQMTGLCSCKPGVAGPKCGQCPDGRALGPAGCEADASAPATCAEMRCEFGARCVEESGSAHCVCPMLTCPEANATKVCGSDGVTYGNECQLKTIACRQGLQISIQSLGPCQEAVAPSTHPTSASVTVTTPGLLLSQALPAPPGALPLAPSSTAHSQTTPPPSSRPRTTASVPRTTVWPVLTVPPTAPSPAPSLVASAFGESGSTDGSSDEELSGDQEASGGGSGGLEPLEGSSVATPGPPVERASCYNSALGCCSDGKTPSLDAEGSNCPATKVFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFRSVRLRDLGPGKSVRAIVDVHFDPTTAFRAPDVARALLRQIQVSRRRSLGVRRPLQEHVRFMDFDWFPAFITGATSGAIAAGATARATTASRLPSSAVTPRAPHPSHTSQPVAKTTAAPTTRRPPTTAPSRVPGRRPPAPQQPPKPCDSQPCFHGGTCQDWALGGGFTCSCPAGRGGAVCEKVLGAPVPAFEGRSFLAFPTLRAYHTLRLALEFRALEPQGLLLYNGNARGKDFLALALLDGRVQLRFDTGSGPAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALERTFVGAGLRGCIRLLDVNNQRLELGIGPGAATRGSGVGECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPTCADEKSPCQPNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTASGQDGSGPFLADFNGFSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRLEFRYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPVPHTVLNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHPCTRASGHPCLNGASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLGSQPVVLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLLEDAVTKPELRPCPTP", "length": 1940, "header": "tr|A0A494C0G5-1|A0A494C0G5_HUMAN Computationally mapped isoform of Agrin OS=Homo sapiens OX=9606 GN=AGRN PE=1 SV=1 CANONICAL=O00468-1" }, "locus": { "chromosome": "1", "start_pos": 1054978, "end_pos": 1034556, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000652369.1", "url": "https://www.ensembl.org/id/ENST00000652369.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000498543.1", "url": "https://www.ensembl.org/id/ENSP00000498543.1" } ] } }, { "isoform_ac": "A0A494C1I6-1", "url": "", "sequence": { "sequence": "MPPLPLARDTRQPPGASLLVRGFMVPCNACLILLATATLGFAVLLFLNNYKPGTHFTPVPPTPPDACRGMLCGFGAVCEPNAEGPGRASCVCKKSPCPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSADGLTASCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQGALPDPSRSCRVNPRTRRPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQCQGRDQCPEPCRFNAVCLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQCAFGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPCDRCGQCRFGALCEAETGRCVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASAGPCETCGDAVCAFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPCEQAECGSGGSGSGEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGACRGPTFAPLPPVAPLHCAQTPYGCCQDNITAARGVGLAGCPSACQCNPHGSYGGTCDPATGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCSCDPQGAVRDDCEQMTGLCSCKPGVAGPKCGQCPDGRALGPAGCEADASAPATCAEMRCEFGARCVEESGSAHCVCPMLTCPEANATKVCGSDGVTYGNECQLKTIACRQGLQISIQSLGPCQEAVAPSTHPTSASVTVTTPGLLLSQALPAPPGALPLAPSSTAHSQTTPPPSSRPRTTASVPRTTVWPVLTVPPTAPSPAPSLVASAFGESGSTDGSSDEELSGDQEASGGGSGGLEPLEGSSVATPGPPVERASCYNSALGCCSDGKTPSLDAEGSNCPATKVFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFRSVRLRDLGPGKSVRAIVDVHFDPTTAFRAPDVARALLRQIQVSRRRSLGVRRPLQEHVRFMDFDWFPAFITGATSGAIAAGATARATTASRLPSSAVTPRAPHPSHTSQPVAKTTAAPTTRRPPTTAPSRVPGRRPPAPQQPPKPCDSQPCFHGGTCQDWALGGGFTCSCPAGRGGAVCEKVLGAPVPAFEGRSFLAFPTLRAYHTLRLALEFRALEPQGLLLYNGNARGKDFLALALLDGRVQLRFDTGSGPAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALERTFVGAGLRGCIRLLDVNNQRLELGIGPGAATRGSGVGECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPTCADEKSPCQPNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTASGQDGSGPFLADFNGFSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRLEFRYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPKSRKVPHTVLNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHPCTRASGHPCLNGASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESELANEIPVPETLDSGALHSEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLGSQPVVLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLLEDAVTKPELRPCPTP", "length": 1963, "header": "tr|A0A494C1I6-1|AGRIN_HUMAN Computationally mapped isoform of Agrin OS=Homo sapiens OX=9606 GN=AGRN PE=1 SV=1 CANONICAL=O00468-1" }, "locus": { "chromosome": "1", "start_pos": 1054978, "end_pos": 1034556, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000651234.1", "url": "https://www.ensembl.org/id/ENST00000651234.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000499046.1", "url": "https://www.ensembl.org/id/ENSP00000499046.1" } ] } }, { "isoform_ac": "O00468-1", "url": "", "sequence": { "sequence": "MAGRSHPGPLRPLLPLLVVAACVLPGAGGTCPERALERREEEANVVLTGTVEEILNVDPVQHTYSCKVRVWRYLKGKDLVARESLLDGGNKVVISGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNELMLNSSLMRITLRNLEEVEFCVEDKPGTHFTPVPPTPPDACRGMLCGFGAVCEPNAEGPGRASCVCKKSPCPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSADGLTASCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQGALPDPSRSCRVNPRTRRPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQCQGRDQCPEPCRFNAVCLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQCAFGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPCDRCGQCRFGALCEAETGRCVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASAGPCETCGDAVCAFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPCEQAECGSGGSGSGEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGACRGPTFAPLPPVAPLHCAQTPYGCCQDNITAARGVGLAGCPSACQCNPHGSYGGTCDPATGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCSCDPQGAVRDDCEQMTGLCSCKPGVAGPKCGQCPDGRALGPAGCEADASAPATCAEMRCEFGARCVEESGSAHCVCPMLTCPEANATKVCGSDGVTYGNECQLKTIACRQGLQISIQSLGPCQEAVAPSTHPTSASVTVTTPGLLLSQALPAPPGALPLAPSSTAHSQTTPPPSSRPRTTASVPRTTVWPVLTVPPTAPSPAPSLVASAFGESGSTDGSSDEELSGDQEASGGGSGGLEPLEGSSVATPGPPVERASCYNSALGCCSDGKTPSLDAEGSNCPATKVFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFRSVRLRDLGPGKSVRAIVDVHFDPTTAFRAPDVARALLRQIQVSRRRSLGVRRPLQEHVRFMDFDWFPAFITGATSGAIAAGATARATTASRLPSSAVTPRAPHPSHTSQPVAKTTAAPTTRRPPTTAPSRVPGRRPPAPQQPPKPCDSQPCFHGGTCQDWALGGGFTCSCPAGRGGAVCEKVLGAPVPAFEGRSFLAFPTLRAYHTLRLALEFRALEPQGLLLYNGNARGKDFLALALLDGRVQLRFDTGSGPAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALERTFVGAGLRGCIRLLDVNNQRLELGIGPGAATRGSGVGECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPTCADEKSPCQPNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTASGQDGSGPFLADFNGFSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRLEFRYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPKSRKVPHTVLNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHPCTRASGHPCLNGASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESELANEIPVPETLDSGALHSEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLGSQPVVLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLLEDAVTKPELRPCPTP", "length": 2068, "header": "sp|O00468-1|AGRIN_HUMAN Isoform 1 of Agrin OS=Homo sapiens OX=9606 GN=AGRN PE=1 SV=6 CANONICAL=O00468-1" }, "locus": {} }, { "isoform_ac": "O00468-2", "url": "", "sequence": { "sequence": "MPXLAVARDTRQPAGASLLVRGFMVPCNACLILLATATLGFAVLLFLNNYDKPGTHFTPVPPTPPDACRGMLCGFGAVCEPNAEGPGRASCVCKKSPCPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSADGLTASCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQGALPDPSRSCRVNPRTRRPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQCQGRDQCPEPCRFNAVCLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQCAFGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPCDRCGQCRFGALCEAETGRCVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASAGPCETCGDAVCAFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPCEQAECGSGGSGSGEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGACRGPTFAPLPPVAPLHCAQTPYGCCQDNITAARGVGLAGCPSACQCNPHGSYGGTCDPATGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCSCDPQGAVRDDCEQMTGLCSCKPGVAGPKCGQCPDGRALGPAGCEADASAPATCAEMRCEFGARCVEESGSAHCVCPMLTCPEANATKVCGSDGVTYGNECQLKTIACRQGLQISIQSLGPCQEAVAPSTHPTSASVTVTTPGLLLSQALPAPPGALPLAPSSTAHSQTTPPPSSRPRTTASVPRTTVWPVLTVPPTAPSPAPSLVASAFGESGSTDGSSDEELSGDQEASGGGSGGLEPLEGSSVATPGPPVERASCYNSALGCCSDGKTPSLDAEGSNCPATKVFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFRSVRLRDLGPGKSVRAIVDVHFDPTTAFRAPDVARALLRQIQVSRRRSLGVRRPLQEHVRFMDFDWFPAFITGATSGAIAAGATARATTASRLPSSAVTPRAPHPSHTSQPVAKTTAAPTTRRPPTTAPSRVPGRRPPAPQQPPKPCDSQPCFHGGTCQDWALGGGFTCSCPAGRGGAVCEKVLGAPVPAFEGRSFLAFPTLRAYHTLRLALEFRALEPQGLLLYNGNARGKDFLALALLDGRVQLRFDTGSGPAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALERTFVGAGLRGCIRLLDVNNQRLELGIGPGAATRGSGVGECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPTCADEKSPCQPNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTASGQDGSGPFLADFNGFSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRLEFRYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPKSRKVPHTVLNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHPCTRASGHPCLNGASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESELANEIPVPETLDSGALHSEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLGSQPVVLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLLEDAVTKPELRPCPTP", "length": 1964, "header": "sp|O00468-2|AGRIN_HUMAN Isoform 2 of Agrin OS=Homo sapiens OX=9606 GN=AGRN PE=1 SV=6 CANONICAL=O00468-1" }, "locus": {} }, { "isoform_ac": "O00468-3", "url": "", "sequence": { "sequence": "MAGRSHPGPLRPLLPLLVVAACVLPGAGGTCPERALERREEEANVVLTGTVEEILNVDPVQHTYSCKVRVWRYLKGKDLVARESLLDGGNKVVISGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNELMLNSSLMRITLRNLEEVEFCVEDKPGTHFTPVPPTPPDACRGMLCGFGAVCEPNAEGPGRASCVCKKSPCPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSADGLTASCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQGALPDPSRSCRVNPRTRRPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQCQGRDQCPEPCRFNAVCLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQCAFGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPCDRCGQCRFGALCEAETGRCVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASAGPCETCGDAVCAFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPCEQAECGSGGSGSGEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGACRGPTFAPLPPVAPLHCAQTPYGCCQDNITAARGVGLAGCPSACQCNPHGSYGGTCDPATGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCSCDPQGAVRDDCEQMTGLCSCKPGVAGPKCGQCPDGRALGPAGCEADASAPATCAEMRCEFGARCVEESGSAHCVCPMLTCPEANATKVCGSDGVTYGNECQLKTIACRQGLQISIQSLGPCQEAVAPSTHPTSASVTVTTPGLLLSQALPAPPGALPLAPSSTAHSQTTPPPSSRPRTTASVPRTTVWPVLTVPPTAPSPAPSLVASAFGESGSTDGSSDEELSGDQEASGGGSGGLEPLEGSSVATPGPPVERASCYNSALGCCSDGKTPSLDAEGSNCPATKVFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFRSVRLRDLGPGKSVRAIVDVHFDPTTAFRAPDVARALLRQIQVSRRRSLGVRRPLQEHVRFMDFDWFPAFITGATSGAIAAGATARATTASRLPSSAVTPRAPHPSHTSQPVAKTTAAPTTRRPPTTAPSRVPGRRPPAPQQPPKPCDSQPCFHGGTCQDWALGGGFTCSCPAGRGGAVCEKVLGAPVPAFEGRSFLAFPTLRAYHTLRLALEFRALEPQGLLLYNGNARGKDFLALALLDGRVQLRFDTGSGPAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALERTFVGAGLRGCIRLLDVNNQRLELGIGPGAATRGSGVGECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPTCADEKSPCQPNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTASGQDGSGPFLADFNGFSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRLEFRYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPKSRKVPHTVLNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHPCTRASGHPCLNGASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLGSQPVVLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLLEDAVTKPELRPCPTP", "length": 2049, "header": "sp|O00468-3|AGRIN_HUMAN Isoform 3 of Agrin OS=Homo sapiens OX=9606 GN=AGRN PE=1 SV=6 CANONICAL=O00468-1" }, "locus": {} }, { "isoform_ac": "O00468-4", "url": "", "sequence": { "sequence": "MAGRSHPGPLRPLLPLLVVAACVLPGAGGTCPERALERREEEANVVLTGTVEEILNVDPVQHTYSCKVRVWRYLKGKDLVARESLLDGGNKVVISGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNELMLNSSLMRITLRNLEEVEFCVEDKPGTHFTPVPPTPPDACRGMLCGFGAVCEPNAEGPGRASCVCKKSPCPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSADGLTASCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQGALPDPSRSCRVNPRTRRPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQCQGRDQCPEPCRFNAVCLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQCAFGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPCDRCGQCRFGALCEAETGRCVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASAGPCETCGDAVCAFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPCEQAECGSGGSGSGEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGACRGPTFAPLPPVAPLHCAQTPYGCCQDNITAARGVGLAGCPSACQCNPHGSYGGTCDPATGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCSCDPQGAVRDDCEQMTGLCSCKPGVAGPKCGQCPDGRALGPAGCEADASAPATCAEMRCEFGARCVEESGSAHCVCPMLTCPEANATKVCGSDGVTYGNECQLKTIACRQGLQISIQSLGPCQEAVAPSTHPTSASVTVTTPGLLLSQALPAPPGALPLAPSSTAHSQTTPPPSSRPRTTASVPRTTVWPVLTVPPTAPSPAPSLVASAFGESGSTDGSSDEELSGDQEASGGGSGGLEPLEGSSVATPGPPVERASCYNSALGCCSDGKTPSLDAEGSNCPATKVFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFRSVRLRDLGPGKSVRAIVDVHFDPTTAFRAPDVARALLRQIQVSRRRSLGVRRPLQEHVRFMDFDWFPAFITGATSGAIAAGATARATTASRLPSSAVTPRAPHPSHTSQPVAKTTAAPTTRRPPTTAPSRVPGRRPPAPQQPPKPCDSQPCFHGGTCQDWALGGGFTCSCPAGRGGAVCEKVLGAPVPAFEGRSFLAFPTLRAYHTLRLALEFRALEPQGLLLYNGNARGKDFLALALLDGRVQLRFDTGSGPAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALERTFVGAGLRGCIRLLDVNNQRLELGIGPGAATRGSGVGECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPTCADEKSPCQPNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTASGQDGSGPFLADFNGFSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRLEFRYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPKSRKVPHTVLNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHPCTRASGHPCLNGASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESPETLDSGALHSEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLGSQPVVLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLLEDAVTKPELRPCPTP", "length": 2060, "header": "sp|O00468-4|AGRIN_HUMAN Isoform 4 of Agrin OS=Homo sapiens OX=9606 GN=AGRN PE=1 SV=6 CANONICAL=O00468-1" }, "locus": {} }, { "isoform_ac": "O00468-5", "url": "", "sequence": { "sequence": "MAGRSHPGPLRPLLPLLVVAACVLPGAGGTCPERALERREEEANVVLTGTVEEILNVDPVQHTYSCKVRVWRYLKGKDLVARESLLDGGNKVVISGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNELMLNSSLMRITLRNLEEVEFCVEDKPGTHFTPVPPTPPDACRGMLCGFGAVCEPNAEGPGRASCVCKKSPCPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSADGLTASCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQGALPDPSRSCRVNPRTRRPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQCQGRDQCPEPCRFNAVCLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQCAFGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPCDRCGQCRFGALCEAETGRCVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASAGPCETCGDAVCAFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPCEQAECGSGGSGSGEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGACRGPTFAPLPPVAPLHCAQTPYGCCQDNITAARGVGLAGCPSACQCNPHGSYGGTCDPATGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCSCDPQGAVRDDCEQMTGLCSCKPGVAGPKCGQCPDGRALGPAGCEADASAPATCAEMRCEFGARCVEESGSAHCVCPMLTCPEANATKVCGSDGVTYGNECQLKTIACRQGLQISIQSLGPCQEAVAPSTHPTSASVTVTTPGLLLSQALPAPPGALPLAPSSTAHSQTTPPPSSRPRTTASVPRTTVWPVLTVPPTAPSPAPSLVASAFGESGSTDGSSDEELSGDQEASGGGSGGLEPLEGSSVATPGPPVERASCYNSALGCCSDGKTPSLDAEGSNCPATKVFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFRSVRLRDLGPGKSVRAIVDVHFDPTTAFRAPDVARALLRQIQVSRRRSLGVRRPLQEHVRFMDFDWFPAFITGATSGAIAAGATARATTASRLPSSAVTPRAPHPSHTSQPVAKTTAAPTTRRPPTTAPSRVPGRRPPAPQQPPKPCDSQPCFHGGTCQDWALGGGFTCSCPAGRGGAVCEKVLGAPVPAFEGRSFLAFPTLRAYHTLRLALEFRALEPQGLLLYNGNARGKDFLALALLDGRVQLRFDTGSGPAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALERTFVGAGLRGCIRLLDVNNQRLELGIGPGAATRGSGVGECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPTCADEKSPCQPNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTASGQDGSGPFLADFNGFSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRLEFRYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPKSRKVPHTVLNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHPCTRASGHPCLNGASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESELANEIPVEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLGSQPVVLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLLEDAVTKPELRPCPTP", "length": 2057, "header": "sp|O00468-5|AGRIN_HUMAN Isoform 5 of Agrin OS=Homo sapiens OX=9606 GN=AGRN PE=1 SV=6 CANONICAL=O00468-1" }, "locus": {} }, { "isoform_ac": "O00468-6", "url": "", "sequence": { "sequence": "MAGRSHPGPLRPLLPLLVVAACVLPGAGGTCPERALERREEEANVVLTGTVEEILNVDPVQHTYSCKVRVWRYLKGKDLVARESLLDGGNKVVISGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNELMLNSSLMRITLRNLEEVEFCVEDKPGTHFTPVPPTPPDACRGMLCGFGAVCEPNAEGPGRASCVCKKSPCPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSADGLTASCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQGALPDPSRSCRVNPRTRRPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQCQGRDQCPEPCRFNAVCLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQCAFGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPCDRCGQCRFGALCEAETGRCVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASAGPCETCGDAVCAFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPCEQAECGSGGSGSGEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGACRGPTFAPLPPVAPLHCAQTPYGCCQDNITAARGVGLAGCPSACQCNPHGSYGGTCDPATGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCSCDPQGAVRDDCEQMTGLCSCKPGVAGPKCGQCPDGRALGPAGCEADASAPATCAEMRCEFGARCVEESGSAHCVCPMLTCPEANATKVCGSDGVTYGNECQLKTIACRQGLQISIQSLGPCQEAVAPSTHPTSASVTVTTPGLLLSQALPAPPGALPLAPSSTAHSQTTPPPSSRPRTTASVPRTTVWPVLTVPPTAPSPAPSLVASAFGESGSTDGSSDEELSGDQEASGGGSGGLEPLEGSSVATPGPPVERASCYNSALGCCSDGKTPSLDAEGSNCPATKVFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFRSVRLRDLGPGKSVRAIVDVHFDPTTAFRAPDVARALLRQIQVSRRRSLGVRRPLQEHVRFMDFDWFPAFITGATSGAIAAGATARATTASRLPSSAVTPRAPHPSHTSQPVAKTTAAPTTRRPPTTAPSRVPGRRPPAPQQPPKPCDSQPCFHGGTCQDWALGGGFTCSCPAGRGGAVCEKVLGAPVPAFEGRSFLAFPTLRAYHTLRLALEFRALEPQGLLLYNGNARGKDFLALALLDGRVQLRFDTGSGPAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALERTFVGAGLRGCIRLLDVNNQRLELGIGPGAATRGSGVGECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPTCADEKSPCQPNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTASGQDGSGPFLADFNGFSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRLEFRYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPVPHTVLNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHPCTRASGHPCLNGASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLGSQPVVLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLLEDAVTKPELRPCPTP", "length": 2045, "header": "sp|O00468-6|AGRIN_HUMAN Isoform 6 of Agrin OS=Homo sapiens OX=9606 GN=AGRN PE=1 SV=6 CANONICAL=O00468-1" }, "locus": { "chromosome": "1", "start_pos": 1054978, "end_pos": 1020173, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000379370.7", "url": "https://www.ensembl.org/id/ENST00000379370.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000368678.2", "url": "https://www.ensembl.org/id/ENSP00000368678.2" } ] } }, { "isoform_ac": "O00468-7", "url": "", "sequence": { "sequence": "MAGRSHPGPLRPLLPLLVVAACVLPGAGGTCPERALERREEEANVVLTGTVEEILNVDPVQHTYSCKVRVWRYLKGKDLVARESLLDGGNKVVISGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNELMLNSSLMRITLRNLEEVEFCVEDKPGTHFTPVPPTPPDACRGMLCGFGAVCEPNAEGPGRASCVCKKSPCPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSADGLTASCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQGALPDPSRSCRVNPRTRRPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQCQGRDQCPEPCRFNAVCLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQCAFGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPCDRCGQCRFGALCEAETGRCVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASAGPCETCGDAVCAFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPCEQAECGSGGSGSGEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGACRGPTFAPLPPVAPLHCAQTPYGCCQDNITAARGVGLAGCPSACQCNPHGSYGGTCDPATGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCSCDPQGAVRDDCEQMTGLCSCKPGVAGPKCGQCPDGRALGPAGCEADASAPATCAEMRCEFGARCVEESGSAHCVCPMLTCPEANATKVCGSDGVTYGNECQLKTIACRQGLQISIQSLGPCQEAVAPSTHPTSASVTVTTPGLLLSQALPAPPGALPLAPSSTAHSQTTPPPSSRPRTTASVPRTTVWPVLTVPPTAPSPAPSLVASAFGESGSTDGSSDEELSGDQEASGGGSGGLEPLEGSSVATPGPPVERASCYNSALGCCSDGKTPSLDAEGSNCPATKVFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFRSVRLRDLGPGKSVRAIVDVHFDPTTAFRAPDVARALLRQIQVSRRRSLGVRRPLQEHVRFMDFDWFPAFITGATSGAIAAGATARATTASRLPSSAVTPRAPHPSHTSQPVAKTTAAPTTRRPPTTAPSRVPGRRPPAPQQPPKPCDSQPCFHGGTCQDWALGGGFTCSCPAGRGGAVCEKVLGAPVPAFEGRSFLAFPTLRAYHTLRLALEFRALEPQGLLLYNGNARGKDFLALALLDGRVQLRFDTGSGPAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALERTFVGAGLRGCIRLLDVNNQRLELGIGPGAATRGSGVGECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPTCADEKSPCQPNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTASGQDGSGPFLADFNGFSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRLEFRYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPVPHTVLNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHPCTRASGHPCLNGASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESELANEIPVPETLDSGALHSEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLGSQPVVLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLLEDAVTKPELRPCPTP", "length": 2064, "header": "sp|O00468-7|AGRIN_HUMAN Isoform 7 of Agrin OS=Homo sapiens OX=9606 GN=AGRN PE=1 SV=6 CANONICAL=O00468-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "TTASVPR", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 1026, "start_aa": "Thr", "end_pos": 1032, "end_aa": "Arg", "evidence": [ { "id": "O00468", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 1033, "start_aa": "Thr", "end_pos": 1033, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1033", "evidence": [ { "id": "O00468", "database": "UniCarbKB", "url": "" }, { "id": "25813380", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/25813380" }, { "id": "10.1074/mcp.M114.046862", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1074/mcp.M114.046862" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 1034, "start_aa": "Thr", "end_pos": 1034, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1034", "evidence": [ { "id": "O00468", "database": "UniCarbKB", "url": "" }, { "id": "25813380", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/25813380" }, { "id": "10.1074/mcp.M114.046862", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1074/mcp.M114.046862" } ] }, { "glytoucan_ac": "G29068FM", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 1095, "start_aa": "Thr", "end_pos": 1095, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1095", "evidence": [ { "id": "O00468", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 1095, "start_aa": "Thr", "end_pos": 1095, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1095", "evidence": [ { "id": "O00468", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "FMDFDWFPAFITGATSGAIAAGATAR", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 1247, "start_aa": "Phe", "end_pos": 1272, "end_aa": "Arg", "evidence": [ { "id": "O00468", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G29063QY", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 1258, "start_aa": "Thr", "end_pos": 1258, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1258", "evidence": [ { "id": "O00468", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G30190ML", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 1258, "start_aa": "Thr", "end_pos": 1258, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1258", "evidence": [ { "id": "O00468", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 1258, "start_aa": "Thr", "end_pos": 1258, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1258", "evidence": [ { "id": "O00468", "database": "UniCarbKB", "url": "" }, { "id": "25813380", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/25813380" }, { "id": "10.1074/mcp.M114.046862", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1074/mcp.M114.046862" } ] }, { "glytoucan_ac": "G88713AC", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 1258, "start_aa": "Thr", "end_pos": 1258, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1258", "evidence": [ { "id": "O00468", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G27391WQ", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 1261, "start_aa": "Thr", "end_pos": 1261, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1261", "evidence": [ { "id": "O00468", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G29068FM", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 1261, "start_aa": "Thr", "end_pos": 1261, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1261", "evidence": [ { "id": "O00468", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G40740AD", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 1261, "start_aa": "Thr", "end_pos": 1261, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1261", "evidence": [ { "id": "O00468", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 1261, "start_aa": "Thr", "end_pos": 1261, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1261", "evidence": [ { "id": "O00468", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 1261, "start_aa": "Thr", "end_pos": 1261, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1261", "evidence": [ { "id": "O00468", "database": "UniCarbKB", "url": "" }, { "id": "25813380", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/25813380" }, { "id": "10.1074/mcp.M114.046862", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1074/mcp.M114.046862" } ] }, { "glytoucan_ac": "G58001LT", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", 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human glucuronyltransferase, GlcAT-P, an enzyme critical in the biosynthesis of the carbohydrate epitope HNK-1.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Kakuda S, Shiba T, Ishiguro M, Tagawa H, Oka S, Kajihara Y, Kawasaki T, Wakatsuki S, Kato R", "evidence": [ { "database": "Reactome", "id": "R-HSA-1971475", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1971475" } ], "reference": [ { "type": "PubMed", "id": "14993226", "url": "https://glygen.org/publication/PubMed/14993226" } ] }, { "title": "Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2004", "authors": "Simmons G, Reeves JD, Rennekamp AJ, Amberg SM, Piefer AJ, Bates P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], 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Implications for matrix assembly and the pathogenesis of chondrodysplasias.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Mann HH, Ozbek S, Engel J, Paulsson M, Wagener R", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "15075323", "url": "https://glygen.org/publication/PubMed/15075323" } ] }, { "title": "Molecular cloning and characterization of a human multisubstrate specific nucleotide-sugar transporter homologous to Drosophila fringe connection.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Suda T, Kamiyama S, Suzuki M, Kikuchi N, Nakayama K, Narimatsu H, Jigami Y, Aoki T, Nishihara S", "evidence": [ { "database": "Reactome", "id": "R-HSA-2022928", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2022928" } ], "reference": [ { "type": "PubMed", "id": "15082721", "url": "https://glygen.org/publication/PubMed/15082721" } ] }, { "title": "pH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGN.", "journal": "Journal of virology", "date": "2004", "authors": "Yang ZY, Huang Y, Ganesh L, Leung K, Kong WP, Schwartz O, Subbarao K, Nabel GJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "15140961", "url": "https://glygen.org/publication/PubMed/15140961" } ] }, { "title": "S protein of severe acute respiratory syndrome-associated coronavirus mediates entry into hepatoma cell lines and is targeted by neutralizing antibodies in infected patients.", "journal": "Journal of virology", "date": "2004", "authors": "Hofmann H, Hattermann K, Marzi A, Gramberg T, Geier M, Krumbiegel M, Kuate S, Uberla K, Niedrig M, Pohlmann S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "15163706", "url": "https://glygen.org/publication/PubMed/15163706" } ] }, { "title": "A novel missense mutation in the galactosyltransferase-I (B4GALT7) gene in a family exhibiting facioskeletal anomalies and Ehlers-Danlos syndrome resembling the progeroid type.", "journal": "American journal of medical genetics. Part A", "date": "2004", "authors": "Faiyaz-Ul-Haque M, Zaidi SH, Al-Ali M, Al-Mureikhi MS, Kennedy S, Al-Thani G, Tsui LC, Teebi AS", "evidence": [ { "database": "Reactome", "id": "R-HSA-3560783", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3560783" } ], "reference": [ { "type": "PubMed", "id": "15211654", "url": "https://glygen.org/publication/PubMed/15211654" } ] }, { "title": "Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin.", "journal": "The Journal of cell biology", "date": "2004", "authors": "Bix G, Fu J, Gonzalez EM, Macro L, Barker A, Campbell S, Zutter MM, Santoro SA, Kim JK, Hook M, Reed CC, Iozzo RV", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "15240572", "url": "https://glygen.org/publication/PubMed/15240572" } ] }, { "title": "Analysis of the DXD motifs in human xylosyltransferase I required for enzyme activity.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Gotting C, Muller S, Schottler M, Schon S, Prante C, Brinkmann T, Kuhn J, Kleesiek K", "evidence": [ { "database": "Reactome", "id": "R-HSA-1971475", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1971475" } ], "reference": [ { "type": "PubMed", "id": "15294915", "url": "https://glygen.org/publication/PubMed/15294915" } ] }, { "title": "Structural basis for interactions between tenascins and lectican C-type lectin domains: evidence for a crosslinking role for tenascins.", "journal": "Structure (London, England : 1993)", "date": "2004", "authors": "Lundell A, Olin AI, Morgelin M, al-Karadaghi S, Aspberg A, Logan DT", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "15296743", "url": 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"https://glygen.org/publication/PubMed/15345499" } ] }, { "title": "Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Moise AR, Kuksa V, Imanishi Y, Palczewski K", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "15358783", "url": "https://glygen.org/publication/PubMed/15358783" } ] }, { "title": "The fibril-associated collagen IX provides a novel mechanism for cell adhesion to cartilaginous matrix.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Kapyla J, Jaalinoja J, Tulla M, Ylostalo J, Nissinen L, Viitasalo T, Vehvilainen P, Marjomaki V, Nykvist P, Saamanen AM, Farndale RW, Birk DE, Ala-Kokko L, Heino J", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": 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Hecht JT, Goldring MB, Lawler J", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "16051604", "url": "https://glygen.org/publication/PubMed/16051604" } ] }, { "title": "Human alpha1 type IV collagen NC1 domain exhibits distinct antiangiogenic activity mediated by alpha1beta1 integrin.", "journal": "The Journal of clinical investigation", "date": "2005", "authors": "Sudhakar A, Nyberg P, Keshamouni VG, Mannam AP, Li J, Sugimoto H, Cosgrove D, Kalluri R", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "16151532", "url": "https://glygen.org/publication/PubMed/16151532" } ] }, { "title": "Molecular defects in Sanfilippo syndrome type B (mucopolysaccharidosis IIIB).", "journal": "Journal of inherited metabolic disease", "date": "2005", "authors": "Beesley CE, Jackson M, Young EP, Vellodi A, Winchester BG", "evidence": [ { "database": "Reactome", "id": "R-HSA-2024096", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2024096" } ], "reference": [ { "type": "PubMed", "id": "16151907", "url": "https://glygen.org/publication/PubMed/16151907" } ] }, { "title": "Apoa5 Q139X truncation predisposes to late-onset hyperchylomicronemia due to lipoprotein lipase impairment.", "journal": "The Journal of clinical investigation", "date": "2005", "authors": "Marcais C, Verges B, Charriere S, Pruneta V, Merlin M, Billon S, Perrot L, Drai J, Sassolas A, Pennacchio LA, Fruchart-Najib J, Fruchart JC, Durlach V, Moulin P", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "16200213", "url": "https://glygen.org/publication/PubMed/16200213" } ] }, { "title": "Integrin alphaDbeta2, an adhesion receptor up-regulated on macrophage foam cells, exhibits multiligand-binding properties.", "journal": "Blood", "date": "2006", "authors": "Yakubenko VP, Yadav SP, Ugarova TP", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "16239428", "url": "https://glygen.org/publication/PubMed/16239428" } ] }, { "title": "Genetic ablation of polysialic acid causes severe neurodevelopmental defects rescued by deletion of the neural cell adhesion molecule.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Weinhold B, Seidenfaden R, Rockle I, Muhlenhoff M, Schertzinger F, Conzelmann S, Marth JD, Gerardy-Schahn R, Hildebrandt H", "evidence": [ { "database": "Reactome", "id": "R-HSA-419037", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-419037" } ], "reference": [ { "type": "PubMed", "id": "16267048", "url": "https://glygen.org/publication/PubMed/16267048" } ] }, { 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} ] }, { "title": "Identification of agrinSN isoform and muscle-specific receptor tyrosine kinase (MuSK) in sperm.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2006", "authors": "Kumar Priyadarsini, Ferns Michael J, Meizel Stanley", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "reference": [ { "type": "PubMed", "id": "16487930", "url": "https://glygen.org/publication/PubMed/16487930" } ] }, { "title": "Involvement of tenascin-C and PG-M/versican in flexor tenosynovial pathology of idiopathic carpal tunnel syndrome.", "journal": "Histology and histopathology", "date": "2006", "authors": "Tsujii M, Hirata H, Yoshida T, Imanaka-Yoshida K, Morita A, Uchida A", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "16493581", "url": "https://glygen.org/publication/PubMed/16493581" } ] }, { "title": "Integrin alpha3beta1, a novel receptor for alpha3(IV) noncollagenous domain and a trans-dominant Inhibitor for integrin alphavbeta3.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Borza CM, Pozzi A, Borza DB, Pedchenko V, Hellmark T, Hudson BG, Zent R", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "16731529", "url": "https://glygen.org/publication/PubMed/16731529" } ] }, { "title": "Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Eble JA, Kassner A, Niland S, Morgelin M, Grifka J, Grassel S", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "16754661", "url": "https://glygen.org/publication/PubMed/16754661" } ] }, { "title": "The discoidin domain receptor DDR2 is a receptor for type X collagen.", "journal": "Matrix biology : journal of the International Society for Matrix Biology", "date": "2006", "authors": "Leitinger B, Kwan AP", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000171", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000171" } ], "reference": [ { "type": "PubMed", "id": "16806867", "url": "https://glygen.org/publication/PubMed/16806867" } ] }, { "title": "The synergy site of fibronectin is required for strong interaction with the platelet integrin alphaIIbbeta3.", "journal": "Annals of biomedical engineering", "date": "2006", "authors": "Chada D, Mather T, Nollert MU", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "16933105", "url": "https://glygen.org/publication/PubMed/16933105" } ] }, { "title": "Palmitoyl transferase activity of lecithin retinol acyl transferase.", "journal": "Biochemistry", "date": "2006", "authors": "Xue L, Jahng WJ, Gollapalli D, Rando RR", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "16939223", "url": "https://glygen.org/publication/PubMed/16939223" } ] }, { "title": "Identification of the gene encoding the enzyme deficient in mucopolysaccharidosis IIIC (Sanfilippo disease type C).", "journal": "American journal of human genetics", "date": "2006", "authors": "Fan X, Zhang H, Zhang S, Bagshaw RD, Tropak MB, Callahan JW, Mahuran DJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-2024096", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2024096" } ], "reference": [ { "type": "PubMed", "id": "16960811", "url": "https://glygen.org/publication/PubMed/16960811" } ] }, { "title": "A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys.", "journal": "Bone", "date": "2007", "authors": "Kumar S, Dare L, Vasko-Moser JA, James IE, Blake SM, Rickard DJ, Hwang SM, Tomaszek T, Yamashita DS, Marquis RW, Oh H, Jeong JU, Veber DF, Gowen M, Lark MW, Stroup G", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "16962401", "url": "https://glygen.org/publication/PubMed/16962401" } ] }, { "title": "Mutations in TMEM76* cause mucopolysaccharidosis IIIC (Sanfilippo C syndrome).", "journal": "American journal of human genetics", "date": "2006", "authors": "Hrebicek M, Mrazova L, Seyrantepe V, Durand S, Roslin NM, Noskova L, Hartmannova H, Ivanek R, Cizkova A, Poupetova H, Sikora J, Urinovska J, Stranecky V, Zeman J, Lepage P, Roquis D, Verner A, Ausseil J, Beesley CE, Maire I, Poorthuis BJ, van de Kamp J, van Diggelen OP, Wevers RA, Hudson TJ, Fujiwara TM, Majewski J, Morgan K, Kmoch S, Pshezhetsky AV", "evidence": [ { "database": "Reactome", "id": "R-HSA-2024096", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2024096" } ], "reference": [ { "type": "PubMed", "id": "17033958", "url": "https://glygen.org/publication/PubMed/17033958" } ] }, { "title": "XT-II, the second isoform of human peptide-O-xylosyltransferase, displays enzymatic activity.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Voglmeir J, Voglauer R, Wilson IB", "evidence": [ { "database": "Reactome", "id": "R-HSA-1971475", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1971475" } ], "reference": [ { "type": "PubMed", "id": "17194707", "url": "https://glygen.org/publication/PubMed/17194707" } ] }, { "title": "Critical residues of alphaX I-domain recognizing fibrinogen central domain.", "journal": "Biochemical and biophysical research communications", "date": "2007", "authors": "Lee JH, Choi J, Nham SU", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "17339034", "url": "https://glygen.org/publication/PubMed/17339034" } ] }, { "title": "Hydrophobic ligand binding properties of the human lipocalin apolipoprotein M.", "journal": "Journal of lipid research", "date": "2007", "authors": "Ahnstrom J, Faber K, Axler O, Dahlback B", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "17525477", "url": "https://glygen.org/publication/PubMed/17525477" } ] }, { "title": "Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Chen FH, Herndon ME, Patel N, Hecht JT, Tuan RS, Lawler J", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "17588949", "url": "https://glygen.org/publication/PubMed/17588949" } ] }, { "title": "Mechanisms of provitamin A (carotenoid) and vitamin A (retinol) transport into and out of intestinal Caco-2 cells.", "journal": "Journal of lipid research", "date": "2007", "authors": "During A, Harrison EH", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "17644776", "url": "https://glygen.org/publication/PubMed/17644776" } ] }, { "title": "Involvement of alpha(v)beta3 integrins in osteoclast function.", "journal": "Journal of bone and mineral metabolism", "date": "2007", "authors": "Nakamura I, Duong LT, Rodan SB, Rodan GA", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "17968485", "url": "https://glygen.org/publication/PubMed/17968485" } ] }, { "title": "Polysialic acid in the plasticity of the developing and adult vertebrate nervous system.", "journal": "Nature reviews. Neuroscience", "date": "2008", "authors": "Rutishauser U", "evidence": [ { "database": "Reactome", "id": "R-HSA-419037", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-419037" } ], "reference": [ { "type": "PubMed", "id": "18059411", "url": "https://glygen.org/publication/PubMed/18059411" } ] }, { "title": "Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007", "authors": "Gallego O, Ruiz FX, Ardevol A, Dominguez M, Alvarez R, de Lera AR, Rovira C, Farres J, Fita I, Pares X", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "18087047", "url": "https://glygen.org/publication/PubMed/18087047" } ] }, { "title": "In vitro and in vivo characterization of retinoid synthesis from beta-carotene.", "journal": "Archives of biochemistry and biophysics", "date": "2008", "authors": "Fierce Y, de Morais Vieira M, Piantedosi R, Wyss A, Blaner WS, Paik J", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "18295589", "url": "https://glygen.org/publication/PubMed/18295589" } ] }, { "title": "Structural basis of toll-like receptor 3 signaling with double-stranded RNA.", "journal": "Science (New York, N.Y.)", "date": "2008", "authors": "Liu L, Botos I, Wang Y, Leonard JN, Shiloach J, Segal DM, Davies DR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833110", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833110" } ], "reference": [ { "type": "PubMed", "id": "18420935", "url": "https://glygen.org/publication/PubMed/18420935" } ] }, { "title": "The signal peptide anchors apolipoprotein M in plasma lipoproteins and prevents rapid clearance of apolipoprotein M from plasma.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Christoffersen C, Ahnstrom J, Axler O, Christensen EI, Dahlback B, Nielsen LB", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "18460466", "url": "https://glygen.org/publication/PubMed/18460466" } ] }, { "title": "Role of the N- and C-terminal domains in binding of apolipoprotein E isoforms to heparan sulfate and dermatan sulfate: a surface plasmon resonance study.", "journal": "Biochemistry", "date": "2008", "authors": "Yamauchi Y, Deguchi N, Takagi C, Tanaka M, Dhanasekaran P, Nakano M, Handa T, Phillips MC, Lund-Katz S, Saito H", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "18507396", "url": "https://glygen.org/publication/PubMed/18507396" } ] }, { "title": "Neutral and acid retinyl ester hydrolases associated with rat liver microsomes: relationships to microsomal cholesteryl ester hydrolases.", "journal": "Journal of lipid research", "date": "1991", "authors": "Gad MZ, Harrison EH", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "1856611", "url": "https://glygen.org/publication/PubMed/1856611" } ] }, { "title": "missing tag=TI", "journal": "missing tag=JT", "date": "missing", "authors": "author information missing", "evidence": [ { "database": "Reactome", "id": "R-HSA-419037", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-419037" } ], "reference": [ { "type": "PubMed", "id": "18607724", "url": "https://glygen.org/publication/PubMed/18607724" } ] }, { "title": "Aldo-keto reductases from the AKR1B subfamily: retinoid specificity and control of cellular retinoic acid levels.", "journal": "Chemico-biological interactions", "date": "2009", "authors": "Ruiz FX, Gallego O, Ardevol A, Moro A, Dominguez M, Alvarez S, Alvarez R, de Lera AR, Rovira C, Fita I, Pares X, Farres J", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "19014918", "url": "https://glygen.org/publication/PubMed/19014918" } ] }, { "title": "Human beta-galactosidase gene mutations in GM1-gangliosidosis: a common mutation among Japanese adult/chronic cases.", "journal": "American journal of human genetics", "date": "1991", "authors": "Yoshida K, Oshima A, Shimmoto M, Fukuhara Y, Sakuraba H, Yanagisawa N, Suzuki Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-2024096", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2024096" } ], "reference": [ { "type": "PubMed", "id": "1907800", "url": "https://glygen.org/publication/PubMed/1907800" } ] }, { "title": "Retinol saturase promotes adipogenesis and is downregulated in obesity.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2009", "authors": "Schupp M, Lefterova MI, Janke J, Leitner K, Cristancho AG, Mullican SE, Qatanani M, Szwergold N, Steger DJ, Curtin JC, Kim RJ, Suh MJ, Albert MR, Engeli S, Gudas LJ, Lazar MA", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "19139408", "url": "https://glygen.org/publication/PubMed/19139408" } ] }, { "title": "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.", "journal": "Journal of proteome research", "date": "2009", "authors": "Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468#ptm_processing" }, { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "reference": [ { "type": "PubMed", "id": "19159218", "url": "https://glygen.org/publication/PubMed/19159218" } ] }, { "title": "Human beta-galactosidase gene mutations in morquio B disease.", "journal": "American journal of human genetics", "date": "1991", "authors": "Oshima A, Yoshida K, Shimmoto M, Fukuhara Y, Sakuraba H, Suzuki Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-2024096", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2024096" } ], "reference": [ { "type": "PubMed", "id": "1928092", "url": "https://glygen.org/publication/PubMed/1928092" } ] }, { "title": "New mutations of EXT1 and EXT2 genes in German patients with Multiple Osteochondromas.", "journal": "Annals of human genetics", "date": "2009", "authors": "Heinritz W, Huffmeier U, Strenge S, Miterski B, Zweier C, Leinung S, Bohring A, Mitulla B, Peters U, Froster UG", "evidence": [ { "database": "Reactome", "id": "R-HSA-3656237", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3656237" } ], "reference": [ { "type": "PubMed", "id": "19344451", "url": "https://glygen.org/publication/PubMed/19344451" } ] }, { "title": "Human alpha-L-iduronidase: cDNA isolation and expression.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1991", "authors": "Scott HS, Anson DS, Orsborn AM, Nelson PV, Clements PR, Morris CP, Hopwood JJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-2024096", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2024096" } ], "reference": [ { "type": "PubMed", "id": "1946389", "url": "https://glygen.org/publication/PubMed/1946389" } ] }, { "title": "Molecular interplay between endostatin, integrins, and heparan sulfate.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Faye C, Moreau C, Chautard E, Jetne R, Fukai N, Ruggiero F, Humphries MJ, Olsen BR, Ricard-Blum S", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "19502598", "url": "https://glygen.org/publication/PubMed/19502598" } ] }, { "title": "Identification of an agrin mutation that causes congenital myasthenia and affects synapse function.", "journal": "American journal of human genetics", "date": "2009", "authors": "Huze C, Bauche S, Richard P, Chevessier F, Goillot E, Gaudon K, Ben Ammar A, Chaboud A, Grosjean I, Lecuyer HA, Bernard V, Rouche A, Alexandri N, Kuntzer T, Fardeau M, Fournier E, Brancaccio A, Ruegg MA, Koenig J, Eymard B, Schaeffer L, Hantai D", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "reference": [ { "type": "PubMed", "id": "19631309", "url": "https://glygen.org/publication/PubMed/19631309" } ] }, { "title": "Cartilage oligomeric matrix protein promotes cell attachment via two independent mechanisms involving CD47 and alphaVbeta3 integrin.", "journal": "Molecular and cellular biochemistry", "date": "2010", "authors": "Rock MJ, Holden P, Horton WA, Cohn DH", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "20033473", "url": "https://glygen.org/publication/PubMed/20033473" } ] }, { "title": "Thrombospondin-induced adhesion of human platelets.", "journal": "The Journal of clinical investigation", "date": "1991", "authors": "Tuszynski GP, Kowalska MA", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "2010551", "url": "https://glygen.org/publication/PubMed/2010551" } ] }, { "title": "Respiratory syncytial virus-mediated NF-kappa B p65 phosphorylation at serine 536 is dependent on RIG-I, TRAF6, and IKK beta.", "journal": "Journal of virology", "date": "2010", "authors": "Yoboua F, Martel A, Duval A, Mukawera E, Grandvaux N", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833110", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833110" } ], "reference": [ { "type": "PubMed", "id": "20410276", "url": "https://glygen.org/publication/PubMed/20410276" } ] }, { "title": "Proteomics characterization of extracellular space components in the human aorta.", "journal": "Mol. Cell. Proteomics", "date": "2010", "authors": "Didangelos Athanasios, Yin Xiaoke, Mandal Kaushik, Baumert Mark, Jahangiri Marjan, Mayr Manuel", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "reference": [ { "type": "PubMed", "id": "20551380", "url": "https://glygen.org/publication/PubMed/20551380" } ] }, { "title": "Target selection of heparan sulfate hexuronic acid 2-O-sulfotransferase.", "journal": "Glycobiology", "date": "2010", "authors": "Smeds E, Feta A, Kusche-Gullberg M", "evidence": [ { "database": "Reactome", "id": "R-HSA-2022928", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2022928" } ], "reference": [ { "type": "PubMed", "id": "20554947", "url": "https://glygen.org/publication/PubMed/20554947" } ] }, { "title": "Loss-of-function mutations in HPSE2 cause the autosomal recessive urofacial syndrome.", "journal": "American journal of human genetics", "date": "2010", "authors": "Pang J, Zhang S, Yang P, Hawkins-Lee B, Zhong J, Zhang Y, Ochoa B, Agundez JA, Voelckel MA, Fisher RB, Gu W, Xiong WC, Mei L, She JX, Wang CY", "evidence": [ { "database": "Reactome", "id": "R-HSA-2024096", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2024096" } ], "reference": [ { "type": "PubMed", "id": "20560209", "url": "https://glygen.org/publication/PubMed/20560209" } ] }, { "title": "Mutations in HPSE2 cause urofacial syndrome.", "journal": "American journal of human genetics", "date": "2010", "authors": "Daly SB, Urquhart JE, Hilton E, McKenzie EA, Kammerer RA, Lewis M, Kerr B, Stuart H, Donnai D, Long DA, Burgu B, Aydogdu O, Derbent M, Garcia-Minaur S, Reardon W, Gener B, Shalev S, Smith R, Woolf AS, Black GC, Newman WG", "evidence": [ { "database": "Reactome", "id": "R-HSA-2024096", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2024096" } ], "reference": [ { "type": "PubMed", "id": "20560210", "url": "https://glygen.org/publication/PubMed/20560210" } ] }, { "title": "Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity.", "journal": "The Journal of biological chemistry", "date": "2010", "authors": "Levy-Adam F, Feld S, Cohen-Kaplan V, Shteingauz A, Gross M, Arvatz G, Naroditsky I, Ilan N, Doweck I, Vlodavsky I", "evidence": [ { "database": "Reactome", "id": "R-HSA-2024096", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2024096" } ], "reference": [ { "type": "PubMed", "id": "20576607", "url": "https://glygen.org/publication/PubMed/20576607" } ] }, { "title": "Decorin interacts with fibrillar collagen of embryonic and adult human skin.", "journal": "Journal of structural biology", "date": "1991", "authors": "Fleischmajer R, Fisher LW, MacDonald ED, Jacobs L Jr, Perlish JS, Termine JD", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "2059554", "url": "https://glygen.org/publication/PubMed/2059554" } ] }, { "title": "Analysis of the biogenesis of heparan sulfate acetyl-CoA:alpha-glucosaminide N-acetyltransferase provides insights into the mechanism underlying its complete deficiency in mucopolysaccharidosis IIIC.", "journal": "The Journal of biological chemistry", "date": "2010", "authors": "Durand S, Feldhammer M, Bonneil E, Thibault P, Pshezhetsky AV", "evidence": [ { "database": "Reactome", "id": "R-HSA-2024096", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2024096" } ], "reference": [ { "type": "PubMed", "id": "20650889", "url": "https://glygen.org/publication/PubMed/20650889" } ] }, { "title": "Molecular characterization of beta1,4-galactosyltransferase 7 genetic mutations linked to the progeroid form of Ehlers-Danlos syndrome (EDS).", "journal": "FEBS letters", "date": "2010", "authors": "Bui C, Talhaoui I, Chabel M, Mulliert G, Coughtrie MW, Ouzzine M, Fournel-Gigleux S", "evidence": [ { "database": "Reactome", "id": "R-HSA-3560783", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3560783" } ], "reference": [ { "type": "PubMed", "id": "20691685", "url": "https://glygen.org/publication/PubMed/20691685" } ] }, { "title": "Lumican inhibits cell migration through alpha2beta1 integrin.", "journal": "Experimental cell research", "date": "2010", "authors": "Zeltz C, Brezillon S, Kapyla J, Eble JA, Bobichon H, Terryn C, Perreau C, Franz CM, Heino J, Maquart FX, Wegrowski Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "20705068", "url": "https://glygen.org/publication/PubMed/20705068" } ] }, { "title": "A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry.", "journal": "Journal of virology", "date": "2011", "authors": "Shulla A, Heald-Sargent T, Subramanya G, Zhao J, Perlman S, Gallagher T", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "21068237", "url": "https://glygen.org/publication/PubMed/21068237" } ] }, { "title": "A mitochondrial enzyme degrades carotenoids and protects against oxidative stress.", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "date": "2011", "authors": "Amengual J, Lobo GP, Golczak M, Li HN, Klimova T, Hoppel CL, Wyss A, Palczewski K, von Lintig J", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "21106934", "url": "https://glygen.org/publication/PubMed/21106934" } ] }, { "title": "Hunter syndrome: isolation of an iduronate-2-sulfatase cDNA clone and analysis of patient DNA.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1990", "authors": "Wilson PJ, Morris CP, Anson DS, Occhiodoro T, Bielicki J, Clements PR, Hopwood JJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-2024096", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2024096" } ], "reference": [ { "type": "PubMed", "id": "2122463", "url": "https://glygen.org/publication/PubMed/2122463" } ] }, { "title": "Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response.", "journal": "Journal of virology", "date": "2011", "authors": "Glowacka I, Bertram S, Muller MA, Allen P, Soilleux E, Pfefferle S, Steffen I, Tsegaye TS, He Y, Gnirss K, Niemeyer D, Schneider H, Drosten C, Pohlmann S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "21325420", "url": "https://glygen.org/publication/PubMed/21325420" } ] }, { "title": "Dentin matrix protein 1 (DMP1) signals via cell surface integrin.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Wu H, Teng PN, Jayaraman T, Onishi S, Li J, Bannon L, Huang H, Close J, Sfeir C", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "21642437", "url": "https://glygen.org/publication/PubMed/21642437" } ] }, { "title": "Faulty initiation of proteoglycan synthesis causes cardiac and joint defects.", "journal": "American journal of human genetics", "date": "2011", "authors": "Baasanjav S, Al-Gazali L, Hashiguchi T, Mizumoto S, Fischer B, Horn D, Seelow D, Ali BR, Aziz SA, Langer R, Saleh AA, Becker C, Nurnberg G, Cantagrel V, Gleeson JG, Gomez D, Michel JB, Stricker S, Lindner TH, Nurnberg P, Sugahara K, Mundlos S, Hoffmann K", "evidence": [ { "database": "Reactome", "id": "R-HSA-3560801", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3560801" } ], "reference": [ { "type": "PubMed", "id": "21763480", "url": "https://glygen.org/publication/PubMed/21763480" } ] }, { "title": "Collagen I and III and their decorin modified surfaces studied by atomic force microscopy and the elucidation of their affinity toward positive apolipoprotein B-100 residue by quartz crystal microbalance.", "journal": "The Analyst", "date": "2011", "authors": "Witos J, Saint-Guirons J, Meinander K, D'Ulivo L, Riekkola ML", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "21789315", "url": "https://glygen.org/publication/PubMed/21789315" } ] }, { "title": "Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.", "journal": "The Biochemical journal", "date": "2011", "authors": "Ruiz FX, Porte S, Gallego O, Moro A, Ardevol A, Del Rio-Espinola A, Rovira C, Farres J, Pares X", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "21851338", "url": "https://glygen.org/publication/PubMed/21851338" } ] }, { "title": "Agrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific kinase (MuSK).", "journal": "The Journal of biological chemistry", "date": "2011-11-25", "authors": "Zhang Wei, Coldefy Anne-Sophie, Hubbard Stevan R, Burden Steven J", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "reference": [ { "type": "PubMed", "id": "21969364", "url": "https://glygen.org/publication/PubMed/21969364" } ] }, { "title": "Respiratory syncytial virus glycoprotein G interacts with DC-SIGN and L-SIGN to activate ERK1 and ERK2.", "journal": "Journal of virology", "date": "2012-02", "authors": "Johnson Teresa R, McLellan Jason S, Graham Barney S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833110", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833110" } ], "reference": [ { "type": "PubMed", "id": "22090124", "url": "https://glygen.org/publication/PubMed/22090124" } ] }, { "title": "Dentin phosphoprotein (DPP) activates integrin-mediated anchorage-dependent signals in undifferentiated mesenchymal cells.", "journal": "The Journal of biological chemistry", "date": "2012", "authors": "Eapen A, Ramachandran A, George A", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "22134916", "url": "https://glygen.org/publication/PubMed/22134916" } ] }, { "title": "LG2 agrin mutation causing severe congenital myasthenic syndrome mimics functional characteristics of non-neural (z-) agrin.", "journal": "Human genetics", "date": "2012", "authors": "Maselli RA, Fernandez JM, Arredondo J, Navarro C, Ngo M, Beeson D, Cagney O, Williams DC, Wollmann RL, Yarov-Yarovoy V, Ferns MJ", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "reference": [ { "type": "PubMed", "id": "22205389", "url": "https://glygen.org/publication/PubMed/22205389" } ] }, { "title": "Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry.", "journal": "Journal of virology", "date": "2012", "authors": "Kawase M, Shirato K, van der Hoek L, Taguchi F, Matsuyama S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "22496216", "url": "https://glygen.org/publication/PubMed/22496216" } ] }, { "title": "Tetrastatin, the NC1 domain of the alpha4(IV) collagen chain: a novel potent anti-tumor matrikine.", "journal": "PloS one", "date": "2012", "authors": "Brassart-Pasco S, Senechal K, Thevenard J, Ramont L, Devy J, Di Stefano L, Dupont-Deshorgue A, Brezillon S, Feru J, Jazeron JF, Diebold MD, Ricard-Blum S, Maquart FX, Monboisse JC", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "22539938", "url": "https://glygen.org/publication/PubMed/22539938" } ] }, { "title": "C-terminal Agrin Fragment as a potential marker for sarcopenia caused by degeneration of the neuromuscular junction.", "journal": "Exp. Gerontol.", "date": "2013", "authors": "Drey M, Sieber C C, Bauer J M, Uter W, Dahinden P, Fariello R G, Vrijbloed J W,", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "reference": [ { "type": "PubMed", "id": "22683512", "url": "https://glygen.org/publication/PubMed/22683512" } ] }, { "title": "Mechanisms of coronavirus cell entry mediated by the viral spike protein.", "journal": "Viruses", "date": "2012", "authors": "Belouzard S, Millet JK, Licitra BN, Whittaker GR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "22816037", "url": "https://glygen.org/publication/PubMed/22816037" } ] }, { "title": "Target-derived matricryptins organize cerebellar synapse formation through alpha3beta1 integrins.", "journal": "Cell reports", "date": "2012", "authors": "Su J, Stenbjorn RS, Gorse K, Su K, Hauser KF, Ricard-Blum S, Pihlajaniemi T, Fox MA", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "22884367", "url": "https://glygen.org/publication/PubMed/22884367" } ] }, { "title": "Quantification of the N-glycosylated secretome by super-SILAC during breast cancer progression and in human blood samples.", "journal": "Molecular & cellular proteomics : MCP", "date": "2013", "authors": "Boersema PJ, Geiger T, Wisniewski JR, Mann M", "evidence": [ { "database": "GlyGen", "id": "GLY_000143", "url": "https://data.glygen.org/GLY_000143" } ], "reference": [ { "type": "PubMed", "id": "23090970", "url": "https://glygen.org/publication/PubMed/23090970" } ] }, { "title": "Effects of some antituberculous and anti-leprotic drugs on cathepsins B, H and L.", "journal": "Indian journal of clinical biochemistry : IJCB", "date": "2003", "authors": "Kamboj RC, Raghav N, Mittal A, Khurana S, Sadana R, Singh H", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "23105391", "url": "https://glygen.org/publication/PubMed/23105391" } ] }, { "title": "Endorepellin laminin-like globular 1/2 domains bind Ig3-5 of vascular endothelial growth factor (VEGF) receptor 2 and block pro-angiogenic signaling by VEGFA in endothelial cells.", "journal": "The FEBS journal", "date": "2013", "authors": "Willis CD, Poluzzi C, Mongiat M, Iozzo RV", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "23374253", "url": "https://glygen.org/publication/PubMed/23374253" } ] }, { "title": "Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology.", "journal": "The EMBO journal", "date": "2013", "authors": "Steentoft C, Vakhrushev SY, Joshi HJ, Kong Y, Vester-Christensen MB, Schjoldager KT, Lavrsen K, Dabelsteen S, Pedersen NB, Marcos-Silva L, Gupta R, Bennett EP, Mandel U, Brunak S, Wandall HH, Levery SB, Clausen H", "evidence": [ { "database": "UniCarbKB", "id": "O00468", "url": "" } ], "reference": [ { "type": "PubMed", "id": "23584533", "url": "https://glygen.org/publication/PubMed/23584533" } ] }, { "title": "Immunoelectron microscopy of osteonectin and type I collagen in osteoblasts and bone matrix.", "journal": "Calcified tissue international", "date": "1990", "authors": "Romanowski R, Jundt G, Termine JD, von der Mark K, Schulz A", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "2364322", "url": "https://glygen.org/publication/PubMed/2364322" } ] }, { "title": "Mutations in B3GALT6, which encodes a glycosaminoglycan linker region enzyme, cause a spectrum of skeletal and connective tissue disorders.", "journal": "American journal of human genetics", "date": "2013", "authors": "Nakajima M, Mizumoto S, Miyake N, Kogawa R, Iida A, Ito H, Kitoh H, Hirayama A, Mitsubuchi H, Miyazaki O, Kosaki R, Horikawa R, Lai A, Mendoza-Londono R, Dupuis L, Chitayat D, Howard A, Leal GF, Cavalcanti D, Tsurusaki Y, Saitsu H, Watanabe S, Lausch E, Unger S, Bonafe L, Ohashi H, Superti-Furga A, Matsumoto N, Sugahara K, Nishimura G, Ikegawa S", "evidence": [ { "database": "Reactome", "id": "R-HSA-4420332", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4420332" } ], "reference": [ { "type": "PubMed", "id": "23664117", "url": "https://glygen.org/publication/PubMed/23664117" } ] }, { "title": "Defective initiation of glycosaminoglycan synthesis due to B3GALT6 mutations causes a pleiotropic Ehlers-Danlos-syndrome-like connective tissue disorder.", "journal": "American journal of human genetics", "date": "2013", "authors": "Malfait F, Kariminejad A, Van Damme T, Gauche C, Syx D, Merhi-Soussi F, Gulberti S, Symoens S, Vanhauwaert S, Willaert A, Bozorgmehr B, Kariminejad MH, Ebrahimiadib N, Hausser I, Huysseune A, Fournel-Gigleux S, De Paepe A", "evidence": [ { "database": "Reactome", "id": "R-HSA-4420332", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4420332" } ], "reference": [ { "type": "PubMed", "id": "23664118", "url": "https://glygen.org/publication/PubMed/23664118" } ] }, { "title": "Two carotenoid oxygenases contribute to mammalian provitamin A metabolism.", "journal": "The Journal of biological chemistry", "date": "2013", "authors": "Amengual J, Widjaja-Adhi MA, Rodriguez-Santiago S, Hessel S, Golczak M, Palczewski K, von Lintig J", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "24106281", "url": "https://glygen.org/publication/PubMed/24106281" } ] }, { "title": "A 125/115-kDa cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectin.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1985", "authors": "Pytela R, Pierschbacher MD, Ruoslahti E", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "2412224", "url": "https://glygen.org/publication/PubMed/2412224" } ] }, { "title": "N-linked glycosylation enrichment for in-depth cell surface proteomics of diffuse large B-cell lymphoma subtypes.", "journal": "Molecular & cellular proteomics : MCP", "date": "2014", "authors": "Deeb SJ, Cox J, Schmidt-Supprian M, Mann M", "evidence": [ { "database": "GlyGen", "id": "GLY_000143", "url": "https://data.glygen.org/GLY_000143" } ], "reference": [ { "type": "PubMed", "id": "24190977", "url": "https://glygen.org/publication/PubMed/24190977" } ] }, { "title": "Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptors.", "journal": "Science (New York, N.Y.)", "date": "1986", "authors": "Pytela R, Pierschbacher MD, Ginsberg MH, Plow EF, Ruoslahti E", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "2420006", "url": "https://glygen.org/publication/PubMed/2420006" } ] }, { "title": "TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein.", "journal": "Journal of virology", "date": "2014", "authors": "Heurich A, Hofmann-Winkler H, Gierer S, Liepold T, Jahn O, Pohlmann S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "24227843", "url": "https://glygen.org/publication/PubMed/24227843" } ] }, { "title": "Interaction of vitronectin with collagen.", "journal": "The Journal of biological chemistry", "date": "1986", "authors": "Gebb C, Hayman EG, Engvall E, Ruoslahti E", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "2430969", "url": "https://glygen.org/publication/PubMed/2430969" } ] }, { "title": "Ehlers-Danlos syndrome associated with glycosaminoglycan abnormalities.", "journal": "Advances in experimental medicine and biology", "date": "2014", "authors": "Miyake N, Kosho T, Matsumoto N", "evidence": [ { "database": "Reactome", "id": "R-HSA-3560783", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3560783" } ], "reference": [ { "type": "PubMed", "id": "24443026", "url": "https://glygen.org/publication/PubMed/24443026" } ] }, { "title": "Agrin mutations lead to a congenital myasthenic syndrome with distal muscle weakness and atrophy.", "journal": "Brain : a journal of neurology", "date": "2014", "authors": "Nicole S, Chaouch A, Torbergsen T, Bauche S, de Bruyckere E, Fontenille MJ, Horn MA, van Ghelue M, Loseth S, Issop Y, Cox D, Muller JS, Evangelista T, Stalberg E, Ioos C, Barois A, Brochier G, Sternberg D, Fournier E, Hantai D, Abicht A, Dusl M, Laval SH, Griffin H, Eymard B, Lochmuller H", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "reference": [ { "type": "PubMed", "id": "24951643", "url": "https://glygen.org/publication/PubMed/24951643" } ] }, { "title": "Probing the O-glycoproteome of gastric cancer cell lines for biomarker discovery.", "journal": "Molecular & cellular proteomics : MCP", "date": "2015", "authors": "Campos D, Freitas D, Gomes J, Magalhaes A, Steentoft C, Gomes C, Vester-Christensen MB, Ferreira JA, Afonso LP, Santos LL, Pinto de Sousa J, Mandel U, Clausen H, Vakhrushev SY, Reis CA", "evidence": [ { "database": "UniCarbKB", "id": "O00468", "url": "" } ], "reference": [ { "type": "PubMed", "id": "25813380", "url": "https://glygen.org/publication/PubMed/25813380" } ] }, { "title": "Interaction between human BAP31 and respiratory syncytial virus small hydrophobic (SH) protein.", "journal": "Virology", "date": "2015-08", "authors": "Li Yan, Jain Neeraj, Limpanawat Suweeraya, To Janet, Quistgaard Esben M, Nordlund Par, Thanabalu Thirumaran, Torres Jaume", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833110", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833110" } ], "reference": [ { "type": "PubMed", "id": "25854864", "url": "https://glygen.org/publication/PubMed/25854864" } ] }, { "title": "Genome-Wide Screen Reveals Valosin-Containing Protein Requirement for Coronavirus Exit from Endosomes.", "journal": "Journal of virology", "date": "2015", "authors": "Wong HH, Kumar P, Tay FP, Moreau D, Liu DX, Bard F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "26311884", "url": "https://glygen.org/publication/PubMed/26311884" } ] }, { "title": "Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV).", "journal": "The Journal of biological chemistry", "date": "2016", "authors": "Zhou N, Pan T, Zhang J, Li Q, Zhang X, Bai C, Huang F, Peng T, Zhang J, Liu C, Tao L, Zhang H", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "26953343", "url": "https://glygen.org/publication/PubMed/26953343" } ] }, { "title": "In vitro characterization of TMPRSS2 inhibition in IPEC-J2 cells.", "journal": "Journal of enzyme inhibition and medicinal chemistry", "date": "2016", "authors": "Paszti-Gere E, Czimmermann E, Ujhelyi G, Balla P, Maiwald A, Steinmetzer T", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "27277342", "url": "https://glygen.org/publication/PubMed/27277342" } ] }, { "title": "Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay.", "journal": "Antimicrobial agents and chemotherapy", "date": "2016", "authors": "Yamamoto M, Matsuyama S, Li X, Takeda M, Kawaguchi Y, Inoue JI, Matsuda Z", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "27550352", "url": "https://glygen.org/publication/PubMed/27550352" } ] }, { "title": "Hydrolysis of retinyl palmitate by enzymes of rat pancreas and liver. Differentiation of bile salt-dependent and bile salt-independent, neutral retinyl ester hydrolases in rat liver.", "journal": "The Journal of biological chemistry", "date": "1989", "authors": "Harrison EH, Gad MZ", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "2793848", "url": "https://glygen.org/publication/PubMed/2793848" } ] }, { "title": "Binding properties of the neural cell adhesion molecule to different components of the extracellular matrix.", "journal": "Journal of neurochemistry", "date": "1989", "authors": "Probstmeier R, Kuhn K, Schachner M", "evidence": [ { "database": "Reactome", "id": "R-HSA-419037", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-419037" } ], "reference": [ { "type": "PubMed", "id": "2809592", "url": "https://glygen.org/publication/PubMed/2809592" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "O00468", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00468" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Respiratory syncytial virus prolifically infects N2a neuronal cells, leading to TLR4 and nucleolin protein modulations and RSV F protein co-localization with TLR4 and nucleolin.", "journal": "Journal of biomedical science", "date": "2018", "authors": "Yuan X, Hu T, He H, Qiu H, Wu X, Chen J, Wang M, Chen C, Huang S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9820960", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9820960" } ], "reference": [ { "type": "PubMed", "id": "29427996", "url": "https://glygen.org/publication/PubMed/29427996" } ] }, { "title": "Site-Specific Profiling of Serum Glycoproteins Using N-Linked Glycan and Glycosite Analysis Revealing Atypical N-Glycosylation Sites on Albumin and alpha-1B-Glycoprotein.", "journal": "Analytical chemistry", "date": "2018", "authors": "Sun S, Hu Y, Jia L, Eshghi ST, Liu Y, Shah P, Zhang H", "evidence": [ { "database": "UniCarbKB", "id": "O00468", "url": "" }, { "database": "GlyConnect", "id": "998", "url": "https://glyconnect.expasy.org/browser/proteins/998" } ], "reference": [ { "type": "PubMed", "id": "29671580", "url": "https://glygen.org/publication/PubMed/29671580" } ] }, { "title": "Reanalysis of Global Proteomic and Phosphoproteomic Data Identified a Large Number of Glycopeptides.", "journal": "Analytical chemistry", "date": "2018", "authors": "Hu Y, Shah P, Clark DJ, Ao M, Zhang H", "evidence": [ { "database": "UniCarbKB", "id": "O00468", "url": "" }, { "database": "GlyConnect", "id": "998", "url": "https://glyconnect.expasy.org/browser/proteins/998" } ], "reference": [ { "type": "PubMed", "id": "29741879", "url": "https://glygen.org/publication/PubMed/29741879" } ] }, { "title": "Mapping the O-glycoproteome using site-specific extraction of O-linked glycopeptides (EXoO).", "journal": "Molecular systems biology", "date": "2018", "authors": "Yang W, Ao M, Hu Y, Li QK, Zhang H", "evidence": [ { "database": "UniCarbKB", "id": "O00468", "url": "" } ], "reference": [ { "type": "PubMed", "id": "30459171", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "title": "Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target.", "journal": "Intensive care medicine", "date": "2020", "authors": "Zhang H, Penninger JM, Li Y, Zhong N, Slutsky AS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "32125455", "url": "https://glygen.org/publication/PubMed/32125455" } ] }, { "title": "SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.", "journal": "Cell", "date": "2020", "authors": "Hoffmann M, Kleine-Weber H, Schroeder S, Kruger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, Muller MA, Drosten C, Pohlmann S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "32142651", "url": "https://glygen.org/publication/PubMed/32142651" } ] }, { "title": "Teicoplanin: an alternative drug for the treatment of COVID-19?", "journal": "International journal of antimicrobial agents", "date": "2020", "authors": "Baron SA, Devaux C, Colson P, Raoult D, Rolain JM", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "32179150", "url": "https://glygen.org/publication/PubMed/32179150" } ] }, { "title": "A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells.", "journal": "Molecular cell", "date": "2020", "authors": "Hoffmann M, Kleine-Weber H, Pohlmann S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "32362314", "url": "https://glygen.org/publication/PubMed/32362314" } ] }, { "title": "Proteolytic Cleavage of the SARS-CoV-2 Spike Protein and the Role of the Novel S1/S2 Site.", "journal": "iScience", "date": "2020", "authors": "Jaimes JA, Millet JK, Whittaker GR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "32512386", "url": "https://glygen.org/publication/PubMed/32512386" } ] }, { "title": "The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin.", "journal": "Signal transduction and targeted therapy", "date": "2020", "authors": "Xia S, Lan Q, Su S, Wang X, Xu W, Liu Z, Zhu Y, Wang Q, Lu L, Jiang S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "32532959", "url": "https://glygen.org/publication/PubMed/32532959" } ] }, { "title": "Characterization of heparin and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein binding interactions.", "journal": "Antiviral research", "date": "2020", "authors": "Kim SY, Jin W, Sood A, Montgomery DW, Grant OC, Fuster MM, Fu L, Dordick JS, Woods RJ, Zhang F, Linhardt RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "32653452", "url": "https://glygen.org/publication/PubMed/32653452" } ] }, { "title": "TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells.", "journal": "Life science alliance", "date": "2020", "authors": "Bestle D, Heindl MR, Limburg H, Van Lam van T, Pilgram O, Moulton H, Stein DA, Hardes K, Eickmann M, Dolnik O, Rohde C, Klenk HD, Garten W, Steinmetzer T, Bottcher-Friebertshauser E", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "32703818", "url": "https://glygen.org/publication/PubMed/32703818" } ] }, { "title": "Methods for Enrichment and Assignment of N-Acetylglucosamine Modification Sites.", "journal": "Molecular & cellular proteomics : MCP", "date": "2021", "authors": "Maynard JC, Chalkley RJ", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "O00468", "url": "https://oglcnac.org/atlas/detail/O00468" } ], "reference": [ { "type": "PubMed", "id": "32938750", "url": "https://glygen.org/publication/PubMed/32938750" } ] }, { "title": "SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2.", "journal": "Cell", "date": "2020", "authors": "Clausen TM, Sandoval DR, Spliid CB, Pihl J, Perrett HR, Painter CD, Narayanan A, Majowicz SA, Kwong EM, McVicar RN, Thacker BE, Glass CA, Yang Z, Torres JL, Golden GJ, Bartels PL, Porell RN, Garretson AF, Laubach L, Feldman J, Yin X, Pu Y, Hauser BM, Caradonna TM, Kellman BP, Martino C, Gordts PLSM, Chanda SK, Schmidt AG, Godula K, Leibel SL, Jose J, Corbett KD, Ward AB, Carlin AF, Esko JD", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "32970989", "url": "https://glygen.org/publication/PubMed/32970989" } ] }, { "title": "KIM-1/TIM-1 is a Receptor for SARS-CoV-2 in Lung and Kidney.", "journal": "medRxiv : the preprint server for health sciences", "date": "2022", "authors": "Mori Y, Fink C, Ichimura T, Sako K, Mori M, Lee NN, Aschauer P, Padmanabha Das KM, Hong S, Song M, Padera RF, Weins A, Lee LP, Nasr ML, Dekaban GA, Dikeakos JD, Bonventre JV", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "32995803", "url": "https://glygen.org/publication/PubMed/32995803" } ] }, { "title": "Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity.", "journal": "Science (New York, N.Y.)", "date": "2020", "authors": "Cantuti-Castelvetri L, Ojha R, Pedro LD, Djannatian M, Franz J, Kuivanen S, van der Meer F, Kallio K, Kaya T, Anastasina M, Smura T, Levanov L, Szirovicza L, Tobi A, Kallio-Kokko H, Osterlund P, Joensuu M, Meunier FA, Butcher SJ, Winkler MS, Mollenhauer B, Helenius A, Gokce O, Teesalu T, Hepojoki J, Vapalahti O, Stadelmann C, Balistreri G, Simons M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "33082293", "url": "https://glygen.org/publication/PubMed/33082293" } ] }, { "title": "Neuropilin-1 is a host factor for SARS-CoV-2 infection.", "journal": "Science (New York, N.Y.)", "date": "2020", "authors": "Daly JL, Simonetti B, Klein K, Chen KE, Williamson MK, Anton-Plagaro C, Shoemark DK, Simon-Gracia L, Bauer M, Hollandi R, Greber UF, Horvath P, Sessions RB, Helenius A, Hiscox JA, Teesalu T, Matthews DA, Davidson AD, Collins BM, Cullen PJ, Yamauchi Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "33082294", "url": "https://glygen.org/publication/PubMed/33082294" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "O00468", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00468" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro.", "journal": "Cell discovery", "date": "2020", "authors": "Zhang Q, Chen CZ, Swaroop M, Xu M, Wang L, Lee J, Wang AQ, Pradhan M, Hagen N, Chen L, Shen M, Luo Z, Xu X, Xu Y, Huang W, Zheng W, Ye Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "33298900", "url": "https://glygen.org/publication/PubMed/33298900" } ] }, { "title": "Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion.", "journal": "PLoS pathogens", "date": "2021", "authors": "Papa G, Mallery DL, Albecka A, Welch LG, Cattin-Ortola J, Luptak J, Paul D, McMahon HT, Goodfellow IG, Carter A, Munro S, James LC", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "33493182", "url": "https://glygen.org/publication/PubMed/33493182" } ] }, { "title": "Kidney injury molecule-1 is a potential receptor for SARS-CoV-2.", "journal": "Journal of molecular cell biology", "date": "2021", "authors": "Yang C, Zhang Y, Zeng X, Chen H, Chen Y, Yang D, Shen Z, Wang X, Liu X, Xiong M, Chen H, Huang K", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "33493263", "url": "https://glygen.org/publication/PubMed/33493263" } ] }, { "title": "Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis.", "journal": "Nature", "date": "2021", "authors": "Johnson BA, Xie X, Bailey AL, Kalveram B, Lokugamage KG, Muruato A, Zou J, Zhang X, Juelich T, Smith JK, Zhang L, Bopp N, Schindewolf C, Vu M, Vanderheiden A, Winkler ES, Swetnam D, Plante JA, Aguilar P, Plante KS, Popov V, Lee B, Weaver SC, Suthar MS, Routh AL, Ren P, Ku Z, An Z, Debbink K, Diamond MS, Shi PY, Freiberg AN, Menachery VD", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "33494095", "url": "https://glygen.org/publication/PubMed/33494095" } ] }, { "title": "SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets.", "journal": "eLife", "date": "2021", "authors": "Raghuvamsi PV, Tulsian NK, Samsudin F, Qian X, Purushotorman K, Yue G, Kozma MM, Hwa WY, Lescar J, Bond PJ, MacAry PA, Anand GS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "33554856", "url": "https://glygen.org/publication/PubMed/33554856" } ] }, { "title": "Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development.", "journal": "Signal transduction and targeted therapy", "date": "2021", "authors": "Zhao MM, Yang WL, Yang FY, Zhang L, Huang WJ, Hou W, Fan CF, Jin RH, Feng YM, Wang YC, Yang JK", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "33774649", "url": "https://glygen.org/publication/PubMed/33774649" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "O00468", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00468" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Glycosylation is a key in SARS-CoV-2 infection.", "journal": "Journal of molecular medicine (Berlin, Germany)", "date": "2021", "authors": "Reis CA, Tauber R, Blanchard V", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "34023935", "url": "https://glygen.org/publication/PubMed/34023935" } ] }, { "title": "TMPRSS2 expression dictates the entry route used by SARS-CoV-2 to infect host cells.", "journal": "The EMBO journal", "date": "2021", "authors": "Koch J, Uckeley ZM, Doldan P, Stanifer M, Boulant S, Lozach PY", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "34159616", "url": "https://glygen.org/publication/PubMed/34159616" } ] }, { "title": "Heparan Sulfate Facilitates Spike Protein-Mediated SARS-CoV-2 Host Cell Invasion and Contributes to Increased Infection of SARS-CoV-2 G614 Mutant and in Lung Cancer.", "journal": "Frontiers in molecular biosciences", "date": "2021", "authors": "Yue J, Jin W, Yang H, Faulkner J, Song X, Qiu H, Teng M, Azadi P, Zhang F, Linhardt RJ, Wang L", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "34179075", "url": "https://glygen.org/publication/PubMed/34179075" } ] }, { "title": "Heparan Sulfate Proteoglycans as Attachment Factor for SARS-CoV-2.", "journal": "ACS central science", "date": "2021", "authors": "Liu L, Chopra P, Li X, Bouwman KM, Tompkins SM, Wolfert MA, de Vries RP, Boons GJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "34235261", "url": "https://glygen.org/publication/PubMed/34235261" } ] }, { "title": "Glycosylation of SARS-CoV-2: structural and functional insights.", "journal": "Analytical and bioanalytical chemistry", "date": "2021", "authors": "Shajahan A, Pepi LE, Rouhani DS, Heiss C, Azadi P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "34235568", "url": "https://glygen.org/publication/PubMed/34235568" } ] }, { "title": "SARS-CoV-2 pseudovirus infectivity and expression of viral entry-related factors ACE2, TMPRSS2, Kim-1, and NRP-1 in human cells from the respiratory, urinary, digestive, reproductive, and immune systems.", "journal": "Journal of medical virology", "date": "2021", "authors": "Zhang F, Li W, Feng J, Ramos da Silva S, Ju E, Zhang H, Chang Y, Moore PS, Guo H, Gao SJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "34324210", "url": "https://glygen.org/publication/PubMed/34324210" } ] }, { "title": "Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry.", "journal": "Science China. Life sciences", "date": "2022", "authors": "Zhu S, Liu Y, Zhou Z, Zhang Z, Xiao X, Liu Z, Chen A, Dong X, Tian F, Chen S, Xu Y, Wang C, Li Q, Niu X, Pan Q, Du S, Xiao J, Wang J, Wei W", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "34431042", "url": "https://glygen.org/publication/PubMed/34431042" } ] }, { "title": "Infection and transmission of SARS-CoV-2 depend on heparan sulfate proteoglycans.", "journal": "The EMBO journal", "date": "2021", "authors": "Bermejo-Jambrina M, Eder J, Kaptein TM, van Hamme JL, Helgers LC, Vlaming KE, Brouwer PJM, van Nuenen AC, Spaargaren M, de Bree GJ, Nijmeijer BM, Kootstra NA, van Gils MJ, Sanders RW, Geijtenbeek TBH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "34510494", "url": "https://glygen.org/publication/PubMed/34510494" } ] }, { "title": "SARS-CoV-2 S glycoprotein binding to multiple host receptors enables cell entry and infection.", "journal": "Glycoconjugate journal", "date": "2021", "authors": "Trbojevic-Akmacic I, Petrovic T, Lauc G", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "34542788", "url": "https://glygen.org/publication/PubMed/34542788" } ] }, { "title": "Proteolytic activation of SARS-CoV-2 spike protein.", "journal": "Microbiology and immunology", "date": "2022", "authors": "Takeda M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "34561887", "url": "https://glygen.org/publication/PubMed/34561887" } ] }, { "title": "Mechanisms of SARS-CoV-2 entry into cells.", "journal": "Nature reviews. Molecular cell biology", "date": "2022", "authors": "Jackson CB, Farzan M, Chen B, Choe H", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "34611326", "url": "https://glygen.org/publication/PubMed/34611326" } ] }, { "title": "Cloning, sequencing, and expression of cDNA for human beta-glucuronidase.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1987", "authors": "Oshima A, Kyle JW, Miller RD, Hoffmann JW, Powell PP, Grubb JH, Sly WS, Tropak M, Guise KS, Gravel RA", "evidence": [ { "database": "Reactome", "id": "R-HSA-2024096", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2024096" } ], "reference": [ { "type": "PubMed", "id": "3468507", "url": "https://glygen.org/publication/PubMed/3468507" } ] }, { "title": "Truncation of the TPR domain of OGT alters substrate and glycosite selection.", "journal": "Analytical and bioanalytical chemistry", "date": "2021", "authors": "Ramirez DH, Yang B, D'Souza AK, Shen D, Woo CM", "evidence": [ { "database": "O-GlcNAc Database", "id": "O00468", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00468" } ], "reference": [ { "type": "PubMed", "id": "34725712", "url": "https://glygen.org/publication/PubMed/34725712" } ] }, { "title": "Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2021", "authors": "Zhang L, Mann M, Syed ZA, Reynolds HM, Tian E, Samara NL, Zeldin DC, Tabak LA, Ten Hagen KG", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "34732583", "url": "https://glygen.org/publication/PubMed/34732583" } ] }, { "title": "The glycosylation in SARS-CoV-2 and its receptor ACE2.", "journal": "Signal transduction and targeted therapy", "date": "2021", "authors": "Gong Y, Qin S, Dai L, Tian Z", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "34782609", "url": "https://glygen.org/publication/PubMed/34782609" } ] }, { "title": "The binding of heparin to spike glycoprotein inhibits SARS-CoV-2 infection by three mechanisms.", "journal": "The Journal of biological chemistry", "date": "2022", "authors": "Paiardi G, Richter S, Oreste P, Urbinati C, Rusnati M, Wade RC", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "34929169", "url": "https://glygen.org/publication/PubMed/34929169" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "O00468", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00468" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity.", "journal": "Journal of virology", "date": "2022", "authors": "Essalmani R, Jain J, Susan-Resiga D, Andreo U, Evagelidis A, Derbali RM, Huynh DN, Dallaire F, Laporte M, Delpal A, Sutto-Ortiz P, Coutard B, Mapa C, Wilcoxen K, Decroly E, Nq Pham T, Cohen EA, Seidah NG", "evidence": [ { "database": "Reactome", "id": "R-HSA-9694614", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9694614" } ], "reference": [ { "type": "PubMed", "id": "35343766", "url": "https://glygen.org/publication/PubMed/35343766" } ] }, { "title": "An Unexpected Encounter: Respiratory Syncytial Virus Nonstructural Protein 1 Interacts with Mediator Subunit MED25.", "journal": "Journal of virology", "date": "2022-10-12", "authors": "Van Royen Tessa, Sedeyn Koen, Moschonas George D, Toussaint Wendy, Vuylsteke Marnik, Van Haver Delphi, Impens Francis, Eyckerman Sven, Lemmens Irma, Tavernier Jan, Schepens Bert, Saelens Xavier", "evidence": [ { "database": "Reactome", "id": "R-HSA-9833110", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9833110" } ], "reference": [ { "type": "PubMed", "id": "36102648", "url": "https://glygen.org/publication/PubMed/36102648" } ] }, { "title": "Genes encoding agrin (AGRN) and neurotrypsin (PRSS12) are associated with muscle mass, strength and plasma C-terminal agrin fragment concentration.", "journal": "GeroScience", "date": "2023-06", "authors": "Pratt Jedd, Whitton Laura, Ryan Anthony, Juliusdottir Thorhildur, Dolan Jackie, Conroy Judith, Narici Marco, De Vito Giuseppe, Boreham Colin", "evidence": [ { "database": "RefSeq", "id": "NP_940978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940978" } ], "reference": [ { "type": "PubMed", "id": "36609795", "url": "https://glygen.org/publication/PubMed/36609795" } ] }, { "title": "Transthyretin: a choroid plexus-specific transport protein in human brain. The 1986 S. Weir Mitchell award.", "journal": "Neurology", "date": "1986", "authors": "Herbert J, Wilcox JN, Pham KT, Fremeau RT Jr, Zeviani M, Dwork A, Soprano DR, Makover A, Goodman DS, Zimmerman EA, et al.", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "3714052", "url": "https://glygen.org/publication/PubMed/3714052" } ] }, { "title": "AGRN promotes lung adenocarcinoma progression by activating Notch signaling pathway and acts as a therapeutic target.", "journal": "Pharmacological research", "date": "2023-08", "authors": "Zhang Huan, Liang Jiaqi, Lu Tao, Li Ming, Shan Guangyao, Bi Guoshu, Zhao Mengnan, Jin Xing, Wang Qun, Chen Zhengcong, Zhan Cheng", "evidence": [ { "database": "RefSeq", "id": "NP_940978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940978" } ], "reference": [ { "type": "PubMed", "id": "37321467", "url": "https://glygen.org/publication/PubMed/37321467" } ] }, { "title": "The collagen ColQ binds to LRP4 and regulates the activation of the Muscle-Specific Kinase-LRP4 receptor complex by agrin at the neuromuscular junction.", "journal": "The Journal of biological chemistry", "date": "2023-08", "authors": "Uyen Dao Thi Minh, Barbeau Susie, Mess\u00e9ant Julien, Della-Gaspera Bruno, Bouceba Tahar, Semprez Fannie, Legay Claire, Dobbertin Alexandre", "evidence": [ { "database": "RefSeq", "id": "NP_940978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940978" } ], "reference": [ { "type": "PubMed", "id": "37356721", "url": "https://glygen.org/publication/PubMed/37356721" } ] }, { "title": "Association between the 110-kDa C-terminal agrin fragment and skeletal muscle decline among community-dwelling older women.", "journal": "Journal of cachexia, sarcopenia and muscle", "date": "2023-08-10", "authors": "Kamiya Kuniyasu, Tachiki Takahiro, Sato Yuho, Kouda Katsuyasu, Kajita Etsuko, Tamaki Junko, Kagamimori Sadanobu, Iki Masayuki", "evidence": [ { "database": "RefSeq", "id": "NP_940978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940978" } ], "reference": [ { "type": "PubMed", "id": "37562951", "url": "https://glygen.org/publication/PubMed/37562951" } ] }, { "title": "Bioinformatics-based analysis of the roles of basement membrane-related gene AGRN in systemic lupus erythematosus and pan-cancer development.", "journal": "Frontiers in immunology", "date": "2023", "authors": "Lv Rundong, Duan Lei, Gao Jie, Si Jigang, Feng Chen, Hu Jun, Zheng Xiulan", "evidence": [ { "database": "RefSeq", "id": "NP_940978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940978" } ], "reference": [ { "type": "PubMed", "id": "37841281", "url": "https://glygen.org/publication/PubMed/37841281" } ] }, { "title": "Comparison of apolipoprotein C-II-deficient triacylglycerol-rich lipoproteins and trioleoylglycerol/phosphatidylcholine-stabilized particles as substrates for lipoprotein lipase.", "journal": "Biochimica et biophysica acta", "date": "1986", "authors": "Jackson RL, Tajima S, Yamamura T, Yokoyama S, Yamamoto A", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "3942763", "url": "https://glygen.org/publication/PubMed/3942763" } ] }, { "title": "Interchange of apolipoproteins between chylomicrons and high density lipoproteins during alimentary lipemia in man.", "journal": "The Journal of clinical investigation", "date": "1973", "authors": "Havel RJ, Kane JP, Kashyap ML", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "4345202", "url": "https://glygen.org/publication/PubMed/4345202" } ] }, { "title": "Inhibition of lipoprotein lipase by an apoprotein of human very low density lipoprotein.", "journal": "Biochemical and biophysical research communications", "date": "1972", "authors": "Brown WV, Baginsky ML", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "5057882", "url": "https://glygen.org/publication/PubMed/5057882" } ] }, { "title": "Retinol-binding protein: the transport protein for vitamin A in human plasma.", "journal": "The Journal of clinical investigation", "date": "1968", "authors": "Kanai M, Raz A, Goodman DS", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "5675424", "url": "https://glygen.org/publication/PubMed/5675424" } ] }, { "title": "Human small-intestinal beta-galactosidases. Separation and characterization of one lactase and one hetero beta-galactosidase.", "journal": "The Biochemical journal", "date": "1969", "authors": "Asp NG, Dahlqvist A, Koldovsky O", "evidence": [ { "database": "Reactome", "id": "R-HSA-2024096", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2024096" } ], "reference": [ { "type": "PubMed", "id": "5822067", "url": "https://glygen.org/publication/PubMed/5822067" } ] }, { "title": "Cartilage proteoglycan binding region and link protein. Radioimmunoassays and the detection of masked determinants in aggregates.", "journal": "The Biochemical journal", "date": "1983", "authors": "Ratcliffe A, Hardingham T", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "6193777", "url": "https://glygen.org/publication/PubMed/6193777" } ] }, { "title": "Newly administered [3H]retinol is transferred from hepatocytes to stellate cells in liver for storage.", "journal": "Experimental cell research", "date": "1984", "authors": "Blomhoff R, Holte K, Naess L, Berg T", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "6420172", "url": "https://glygen.org/publication/PubMed/6420172" } ] }, { "title": "Specific inhibition of type I and type II collagen fibrillogenesis by the small proteoglycan of tendon.", "journal": "The Biochemical journal", "date": "1984", "authors": "Vogel KG, Paulsson M, Heinegard D", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "6439184", "url": "https://glygen.org/publication/PubMed/6439184" } ] }, { "title": "The tricho-rhino-phalangeal syndrome with exostoses (or Langer-Giedion syndrome): four additional patients without mental retardation and review of the literature.", "journal": "American journal of medical genetics", "date": "1984", "authors": "Langer LO Jr, Krassikoff N, Laxova R, Scheer-Williams M, Lutter LD, Gorlin RJ, Jennings CG, Day DW", "evidence": [ { "database": "Reactome", "id": "R-HSA-3656253", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3656253" } ], "reference": [ { "type": "PubMed", "id": "6496574", "url": "https://glygen.org/publication/PubMed/6496574" } ] }, { "title": "In vivo uptake of chylomicron [3H]retinyl ester by rat liver: evidence for retinol transfer from parenchymal to nonparenchymal cells.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1982", "authors": "Blomhoff R, Helgerud P, Rasmussen M, Berg T, Norum KR", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "6961410", "url": "https://glygen.org/publication/PubMed/6961410" } ] }, { "title": "Cloning of the sulphamidase gene and identification of mutations in Sanfilippo A syndrome.", "journal": "Nature genetics", "date": "1995", "authors": "Scott HS, Blanch L, Guo XH, Freeman C, Orsborn A, Baker E, Sutherland GR, Morris CP, Hopwood JJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-2024096", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2024096" } ], "reference": [ { "type": "PubMed", "id": "7493035", "url": "https://glygen.org/publication/PubMed/7493035" } ] }, { "title": "Binding of tenascin-C to soluble fibronectin and matrix fibrils.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "Chung CY, Zardi L, Erickson HP", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "7499434", "url": "https://glygen.org/publication/PubMed/7499434" } ] }, { "title": "Solid-phase von Willebrand factor contains a conformationally active RGD motif that mediates endothelial cell adhesion through the alpha v beta 3 receptor.", "journal": "Blood", "date": "1993", "authors": "Denis C, Williams JA, Lu X, Meyer D, Baruch D", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "7505120", "url": "https://glygen.org/publication/PubMed/7505120" } ] }, { "title": "Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain.", "journal": "The Journal of biological chemistry", "date": "1994", "authors": "Nishimura SL, Sheppard D, Pytela R", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "7525578", "url": "https://glygen.org/publication/PubMed/7525578" } ] }, { "title": "Tenascin-R (J1 160/180 inhibits fibronectin-mediated cell adhesion--functional relatedness to tenascin-C.", "journal": "Journal of cell science", "date": "1994", "authors": "Pesheva P, Probstmeier R, Skubitz AP, McCarthy JB, Furcht LT, Schachner M", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "7527058", "url": "https://glygen.org/publication/PubMed/7527058" } ] }, { "title": "The integrin receptor alpha 8 beta 1 mediates interactions of embryonic chick motor and sensory neurons with tenascin-C.", "journal": "Neuron", "date": "1995", "authors": "Varnum-Finney B, Venstrom K, Muller U, Kypta R, Backus C, Chiquet M, Reichardt LF", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "7541634", "url": "https://glygen.org/publication/PubMed/7541634" } ] }, { "title": "CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium.", "journal": "The Journal of cell biology", "date": "1995", "authors": "Piali L, Hammel P, Uherek C, Bachmann F, Gisler RH, Dunon D, Imhof BA", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "7542249", "url": "https://glygen.org/publication/PubMed/7542249" } ] }, { "title": "Alpha v beta 1 is a receptor for vitronectin and fibrinogen, and acts with alpha 5 beta 1 to mediate spreading on fibronectin.", "journal": "Journal of cell science", "date": "1995", "authors": "Marshall JF, Rutherford DC, McCartney AC, Mitjans F, Goodman SL, Hart IR", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "7542669", "url": "https://glygen.org/publication/PubMed/7542669" } ] }, { "title": "Cloning of the putative tumour suppressor gene for hereditary multiple exostoses (EXT1).", "journal": "Nature genetics", "date": "1995", "authors": "Ahn J, Ludecke HJ, Lindow S, Horton WA, Lee B, Wagner MJ, Horsthemke B, Wells DE", "evidence": [ { "database": "Reactome", "id": "R-HSA-3656253", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3656253" } ], "reference": [ { "type": "PubMed", "id": "7550340", "url": "https://glygen.org/publication/PubMed/7550340" } ] }, { "title": "The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "Schnapp LM, Hatch N, Ramos DM, Klimanskaya IV, Sheppard D, Pytela R", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "7559467", "url": "https://glygen.org/publication/PubMed/7559467" } ] }, { "title": "Cloning of the human heparan sulfate-N-deacetylase/N-sulfotransferase gene from the Treacher Collins syndrome candidate region at 5q32-q33.1.", "journal": "Genomics", "date": "1995", "authors": "Dixon J, Loftus SK, Gladwin AJ, Scambler PJ, Wasmuth JJ, Dixon MJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-2022928", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2022928" } ], "reference": [ { "type": "PubMed", "id": "7601448", "url": "https://glygen.org/publication/PubMed/7601448" } ] }, { "title": "Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells.", "journal": "The Journal of biological chemistry", "date": "1993", "authors": "Ji ZS, Brecht WJ, Miranda RD, Hussain MM, Innerarity TL, Mahley RW", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "7683668", "url": "https://glygen.org/publication/PubMed/7683668" } ] }, { "title": "The alpha v beta 5 integrin receptor regulates receptor-mediated endocytosis of vitronectin.", "journal": "The Journal of biological chemistry", "date": "1993", "authors": "Panetti TS, McKeown-Longo PJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "7685013", "url": "https://glygen.org/publication/PubMed/7685013" } ] }, { "title": "Endothelial cell attachment and spreading on human tenascin is mediated by alpha 2 beta 1 and alpha v beta 3 integrins.", "journal": "Journal of cell science", "date": "1993", "authors": "Sriramarao P, Mendler M, Bourdon MA", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "7693733", "url": "https://glygen.org/publication/PubMed/7693733" } ] }, { "title": "Molecular dissection of a contiguous gene syndrome: localization of the genes involved in the Langer-Giedion syndrome.", "journal": "Human molecular genetics", "date": "1995", "authors": "Ludecke HJ, Wagner MJ, Nardmann J, La Pillo B, Parrish JE, Willems PJ, Haan EA, Frydman M, Hamers GJ, Wells DE, et al.", "evidence": [ { "database": "Reactome", "id": "R-HSA-3656253", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3656253" } ], "reference": [ { "type": "PubMed", "id": "7711731", "url": "https://glygen.org/publication/PubMed/7711731" } ] }, { "title": "Interaction of biglycan with type I collagen.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "Schonherr E, Witsch-Prehm P, Harrach B, Robenek H, Rauterberg J, Kresse H", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "7852349", "url": "https://glygen.org/publication/PubMed/7852349" } ] }, { "title": "The expression of functional link protein in a baculovirus system: analysis of mutants lacking the A, B and B' domains.", "journal": "The Biochemical journal", "date": "1994", "authors": "Grover J, Roughley PJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "8002934", "url": "https://glygen.org/publication/PubMed/8002934" } ] }, { "title": "Retinyl ester hydrolytic activity associated with human intestinal brush border membranes.", "journal": "The American journal of clinical nutrition", "date": "1994", "authors": "Rigtrup KM, McEwen LR, Said HM, Ong DE", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "8017323", "url": "https://glygen.org/publication/PubMed/8017323" } ] }, { "title": "Platelet adhesion to collagen types I through VIII under conditions of stasis and flow is mediated by GPIa/IIa (alpha 2 beta 1-integrin).", "journal": "Blood", "date": "1994", "authors": "Saelman EU, Nieuwenhuis HK, Hese KM, de Groot PG, Heijnen HF, Sage EH, Williams S, McKeown L, Gralnick HR, Sixma JJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "8118028", "url": "https://glygen.org/publication/PubMed/8118028" } ] }, { "title": "Demonstration of (Ca(2+)-Mg2+)-ATPase activity of the neural cell adhesion molecule.", "journal": "FEBS letters", "date": "1993", "authors": "Dzhandzhugazyan K, Bock E", "evidence": [ { "database": "Reactome", "id": "R-HSA-419037", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-419037" } ], "reference": [ { "type": "PubMed", "id": "8262246", "url": "https://glygen.org/publication/PubMed/8262246" } ] }, { "title": "Interaction of type IV collagen with the isolated integrins alpha 1 beta 1 and alpha 2 beta 1.", "journal": "European journal of biochemistry", "date": "1993", "authors": "Kern A, Eble J, Golbik R, Kuhn K", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "8344274", "url": "https://glygen.org/publication/PubMed/8344274" } ] }, { "title": "Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1993", "authors": "Episkopou V, Maeda S, Nishiguchi S, Shimada K, Gaitanaris GA, Gottesman ME, Robertson EJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "8384721", "url": "https://glygen.org/publication/PubMed/8384721" } ] }, { "title": "Interaction of heparin cofactor II with biglycan and decorin.", "journal": "The Journal of biological chemistry", "date": "1993", "authors": "Whinna HC, Choi HU, Rosenberg LC, Church FC", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "8440685", "url": "https://glygen.org/publication/PubMed/8440685" } ] }, { "title": "Receptor-ligand interaction between CD44 and osteopontin (Eta-1).", "journal": "Science (New York, N.Y.)", "date": "1996", "authors": "Weber GF, Ashkar S, Glimcher MJ, Cantor H", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "8560266", "url": "https://glygen.org/publication/PubMed/8560266" } ] }, { "title": "Lipoprotein lipase-mediated uptake of lipoprotein in human fibroblasts: evidence for an LDL receptor-independent internalization pathway.", "journal": "Journal of lipid research", "date": "1996", "authors": "Fernandez-Borja M, Bellido D, Vilella E, Olivecrona G, Vilaro S", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "8728311", "url": "https://glygen.org/publication/PubMed/8728311" } ] }, { "title": "Cloning and expression of the gene involved in Sanfilippo B syndrome (mucopolysaccharidosis III B).", "journal": "Human molecular genetics", "date": "1996", "authors": "Weber B, Blanch L, Clements PR, Scott HS, Hopwood JJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-2024096", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2024096" } ], "reference": [ { "type": "PubMed", "id": "8776591", "url": "https://glygen.org/publication/PubMed/8776591" } ] }, { "title": "The EXT2 multiple exostoses gene defines a family of putative tumour suppressor genes.", "journal": "Nature genetics", "date": "1996", "authors": "Stickens D, Clines G, Burbee D, Ramos P, Thomas S, Hogue D, Hecht JT, Lovett M, Evans GA", "evidence": [ { "database": "Reactome", "id": "R-HSA-3656237", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3656237" } ], "reference": [ { "type": "PubMed", "id": "8782816", "url": "https://glygen.org/publication/PubMed/8782816" } ] }, { "title": "Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Yokosaki Y, Monis H, Chen J, Sheppard D", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "8798654", "url": "https://glygen.org/publication/PubMed/8798654" } ] }, { "title": "Identification of alpha v beta 3 as a heterotypic ligand for CD31/PECAM-1.", "journal": "Journal of cell science", "date": "1996", "authors": "Buckley CD, Doyonnas R, Newton JP, Blystone SD, Brown EJ, Watt SM, Simmons DL", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "8838667", "url": "https://glygen.org/publication/PubMed/8838667" } ] }, { "title": "Positional cloning of a gene involved in hereditary multiple exostoses.", "journal": "Human molecular genetics", "date": "1996", "authors": "Wuyts W, Van Hul W, Wauters J, Nemtsova M, Reyniers E, Van Hul EV, De Boulle K, de Vries BB, Hendrickx J, Herrygers I, Bossuyt P, Balemans W, Fransen E, Vits L, Coucke P, Nowak NJ, Shows TB, Mallet L, van den Ouweland AM, McGaughran J, Halley DJ, Willems PJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-3656237", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3656237" } ], "reference": [ { "type": "PubMed", "id": "8894688", "url": "https://glygen.org/publication/PubMed/8894688" } ] }, { "title": "Osteopontin N-terminal domain contains a cryptic adhesive sequence recognized by alpha9beta1 integrin.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Smith LL, Cheung HK, Ling LE, Chen J, Sheppard D, Pytela R, Giachelli CM", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "8910476", "url": "https://glygen.org/publication/PubMed/8910476" } ] }, { "title": "Interaction of cartilage matrix protein with aggrecan. Increased covalent cross-linking with tissue maturation.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Hauser N, Paulsson M, Heinegard D, Morgelin M", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "8943283", "url": "https://glygen.org/publication/PubMed/8943283" } ] }, { "title": "Hereditary multiple exostoses (EXT): mutational studies of familial EXT1 cases and EXT-associated malignancies.", "journal": "American journal of human genetics", "date": "1997", "authors": "Hecht JT, Hogue D, Wang Y, Blanton SH, Wagner M, Strong LC, Raskind W, Hansen MF, Wells D", "evidence": [ { "database": "Reactome", "id": "R-HSA-3656253", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3656253" } ], "reference": [ { "type": "PubMed", "id": "8981950", "url": "https://glygen.org/publication/PubMed/8981950" } ] }, { "title": "Agrin binds to the nerve-muscle basal lamina via laminin.", "journal": "J. Cell Biol.", "date": "1997", "authors": "Denzer AJ, Brandenberger R, Gesemann M, Chiquet M, Ruegg MA", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "reference": [ { "type": "PubMed", "id": "9151673", "url": "https://glygen.org/publication/PubMed/9151673" } ] }, { "title": "The alpha v beta 3 integrin `vitronectin receptor`.", "journal": "The international journal of biochemistry & cell biology", "date": "1997", "authors": "Horton MA", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "9251239", "url": "https://glygen.org/publication/PubMed/9251239" } ] }, { "title": "Localization of a binding site for the proteoglycan decorin on collagen XIV (undulin).", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Ehnis T, Dieterich W, Bauer M, Kresse H, Schuppan D", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "9252349", "url": "https://glygen.org/publication/PubMed/9252349" } ] }, { "title": "Novel mutations in Sanfilippo A syndrome: implications for enzyme function.", "journal": "Human molecular genetics", "date": "1997", "authors": "Weber B, Guo XH, Wraith JE, Cooper A, Kleijer WJ, Bunge S, Hopwood JJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-2024096", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2024096" } ], "reference": [ { "type": "PubMed", "id": "9285796", "url": "https://glygen.org/publication/PubMed/9285796" } ] }, { "title": "The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1997", "authors": "Aspberg A, Miura R, Bourdoulous S, Shimonaka M, Heinegard D, Schachner M, Ruoslahti E, Yamaguchi Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "9294172", "url": "https://glygen.org/publication/PubMed/9294172" } ] }, { "title": "Mutation screening of the EXT1 and EXT2 genes in patients with hereditary multiple exostoses.", "journal": "American journal of human genetics", "date": "1997", "authors": "Philippe C, Porter DE, Emerton ME, Wells DE, Simpson AH, Monaco AP", "evidence": [ { "database": "Reactome", "id": "R-HSA-3656237", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3656237" } ], "reference": [ { "type": "PubMed", "id": "9326317", "url": "https://glygen.org/publication/PubMed/9326317" } ] }, { "title": "Mapping of a defined neurocan binding site to distinct domains of tenascin-C.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Rauch U, Clement A, Retzler C, Frohlich L, Fassler R, Gohring W, Faissner A", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "9341124", "url": "https://glygen.org/publication/PubMed/9341124" } ] }, { "title": "Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Shworak NW, Liu J, Fritze LM, Schwartz JJ, Zhang L, Logeart D, Rosenberg RD", "evidence": [ { "database": "Reactome", "id": "R-HSA-2022928", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2022928" } ], "reference": [ { "type": "PubMed", "id": "9346953", "url": "https://glygen.org/publication/PubMed/9346953" } ] }, { "title": "Identification of hyaluronan-binding domains of aggrecan.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Watanabe H, Cheung SC, Itano N, Kimata K, Yamada Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "9346959", "url": "https://glygen.org/publication/PubMed/9346959" } ] }, { "title": "Demonstration of an extracellular ATP-binding site in NCAM: functional implications of nucleotide binding.", "journal": "Biochemistry", "date": "1997", "authors": "Dzhandzhugazyan K, Bock E", "evidence": [ { "database": "Reactome", "id": "R-HSA-419037", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-419037" } ], "reference": [ { "type": "PubMed", "id": "9398268", "url": "https://glygen.org/publication/PubMed/9398268" } ] }, { "title": "The alphavbeta5 integrin functions as an endocytic receptor for vitronectin.", "journal": "Journal of cell science", "date": "1998", "authors": "Memmo LM, McKeown-Longo P", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "9443892", "url": "https://glygen.org/publication/PubMed/9443892" } ] }, { "title": "Mutations in the EXT1 and EXT2 genes in hereditary multiple exostoses.", "journal": "American journal of human genetics", "date": "1998", "authors": "Wuyts W, Van Hul W, De Boulle K, Hendrickx J, Bakker E, Vanhoenacker F, Mollica F, Ludecke HJ, Sayli BS, Pazzaglia UE, Mortier G, Hamel B, Conrad EU, Matsushita M, Raskind WH, Willems PJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-2022928", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2022928" } ], "reference": [ { "type": "PubMed", "id": "9463333", "url": "https://glygen.org/publication/PubMed/9463333" } ] }, { "title": "Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Kitagawa H, Tone Y, Tamura J, Neumann KW, Ogawa T, Oka S, Kawasaki T, Sugahara K", "evidence": [ { "database": "Reactome", "id": "R-HSA-1971475", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1971475" } ], "reference": [ { "type": "PubMed", "id": "9506957", "url": "https://glygen.org/publication/PubMed/9506957" } ] }, { "title": "Molecular characterization and expression of heparan-sulfate 6-sulfotransferase. Complete cDNA cloning in human and partial cloning in Chinese hamster ovary cells.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Habuchi H, Kobayashi M, Kimata K", "evidence": [ { "database": "Reactome", "id": "R-HSA-2022928", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2022928" } ], "reference": [ { "type": "PubMed", "id": "9535912", "url": "https://glygen.org/publication/PubMed/9535912" } ] }, { "title": "Identification of the ligand binding site for the integrin alpha9 beta1 in the third fibronectin type III repeat of tenascin-C.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Yokosaki Y, Matsuura N, Higashiyama S, Murakami I, Obara M, Yamakido M, Shigeto N, Chen J, Sheppard D", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "9565552", "url": "https://glygen.org/publication/PubMed/9565552" } ] }, { "title": "The putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfate.", "journal": "Nature genetics", "date": "1998", "authors": "McCormick C, Leduc Y, Martindale D, Mattison K, Esford LE, Dyer AP, Tufaro F", "evidence": [ { "database": "Reactome", "id": "R-HSA-3656253", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3656253" } ], "reference": [ { "type": "PubMed", "id": "9620772", "url": "https://glygen.org/publication/PubMed/9620772" } ] }, { "title": "Primary structure and high expression of human agrin in basement membranes of adult lung and kidney.", "journal": "Eur. J. Biochem.", "date": "1998", "authors": "Groffen A J, Buskens C A, van Kuppevelt T H, Veerkamp J H, Monnens L A, van den Heuvel L P", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "reference": [ { "type": "PubMed", "id": "9652404", "url": "https://glygen.org/publication/PubMed/9652404" } ] }, { "title": "The discoidin domain receptor tyrosine kinases are activated by collagen.", "journal": "Molecular cell", "date": "1997", "authors": "Vogel W, Gish GD, Alves F, Pawson T", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000171", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000171" } ], "reference": [ { "type": "PubMed", "id": "9659899", "url": "https://glygen.org/publication/PubMed/9659899" } ] }, { "title": "An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors.", "journal": "Molecular cell", "date": "1997", "authors": "Shrivastava A, Radziejewski C, Campbell E, Kovac L, McGlynn M, Ryan TE, Davis S, Goldfarb MP, Glass DJ, Lemke G, Yancopoulos GD", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000171", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000171" } ], "reference": [ { "type": "PubMed", "id": "9659900", "url": "https://glygen.org/publication/PubMed/9659900" } ] }, { "title": "Cartilage oligomeric matrix protein shows high affinity zinc-dependent interaction with triple helical collagen.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Rosenberg K, Olsson H, Morgelin M, Heinegard D", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "9685393", "url": "https://glygen.org/publication/PubMed/9685393" } ] }, { "title": "Effect of the interaction between fibronectin and VLA-4 on the proliferation of human B cells, especially a novel human B-cell line, OPM-3.", "journal": "British journal of haematology", "date": "1998", "authors": "Yoshida H, Nishiura T, Karasuno T, Matsumura I, Ishikawa J, Yoshimura M, Yokota T, Okajima Y, Ogawa M, Kanakura Y, Tomiyama Y, Matsuzawa Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "9858236", "url": "https://glygen.org/publication/PubMed/9858236" } ] }, { "title": "Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis.", "journal": "Investigative ophthalmology & visual science", "date": "1999", "authors": "Seeliger MW, Biesalski HK, Wissinger B, Gollnick H, Gielen S, Frank J, Beck S, Zrenner E", "evidence": [ { "database": "Reactome", "id": "R-HSA-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-975634" } ], "reference": [ { "type": "PubMed", "id": "9888420", "url": "https://glygen.org/publication/PubMed/9888420" } ] }, { "title": "A 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"https://www.ebi.ac.uk/QuickGO/term/GO:0005796", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "pmid": "" }, { "name": "basement membrane", "id": "GO:0005604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005604", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "pmid": "" }, { "name": "lysosomal lumen", "id": "GO:0043202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043202", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "pmid": "" }, { "name": "collagen-containing extracellular matrix", "id": "GO:0062023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062023", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "pmid": "" }, { "name": "cell periphery", "id": "GO:0071944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071944", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 11, "go_terms": [ { "name": "G protein-coupled acetylcholine receptor signaling pathway", "id": "GO:0007213", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007213", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "pmid": "" }, { "name": "receptor clustering", "id": "GO:0043113", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043113", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "pmid": "" }, { "name": "neuromuscular junction development", "id": "GO:0007528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007528", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "pmid": "" }, { "name": "positive regulation of GTPase activity", "id": "GO:0043547", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043547", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "pmid": "" }, { "name": "synapse organization", "id": "GO:0050808", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050808", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "pmid": "" }, { "name": "clustering of voltage-gated sodium channels", "id": "GO:0045162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045162", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "pmid": "" }, { "name": "positive regulation of synaptic assembly at neuromuscular junction", "id": "GO:0045887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045887", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "pmid": "" }, { "name": "positive regulation of filopodium assembly", "id": "GO:0051491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051491", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "pmid": "" }, { "name": "laminin binding", "id": "GO:0043236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043236", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "pmid": "" }, { "name": "structural constituent of cytoskeleton", "id": "GO:0005200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005200", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "pmid": "" }, { "name": "heparan sulfate proteoglycan binding", "id": "GO:0043395", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043395", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "pmid": "" }, { "name": "dystroglycan binding", "id": "GO:0002162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002162", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "pmid": "" }, { "name": "sialic acid binding", "id": "GO:0033691", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033691", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "pmid": "" }, { "name": "chondroitin sulfate binding", "id": "GO:0035374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035374", "evidence": [ { "database": "UniProtKB", "id": "O00468", "url": "https://www.uniprot.org/uniprot/O00468" } ], "pmid": "" } ] } ] }, "pro_annotation": [ { "name": "agrin N-glycosylated 1 (human)", "definition": "An agrin (human) that has been N-glycosylated at the residue equivalent to Asn-135 of the amino acid sequence represented by UniProtKB:O00468-1, in which the glycan composition is represented by GlyTouCan:G08293MJ. Example: UniProtKB:O00468-1, Asn-135, MOD:00160~GNO:G08293MJ. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000050650", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050650" } ] }, { "name": "agrin O-glycosylated 1 (human)", "definition": "An agrin (human) that has been O-glycosylated at the residue equivalent to Ser-204 of the amino acid sequence represented by UniProtKB:O00468-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O00468-1, Ser-204, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050651", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050651" } ] }, { "name": "agrin O-glycosylated 2 (human)", "definition": "An agrin (human) that has been O-glycosylated at the residue equivalent to Ser-496 of the amino acid sequence represented by UniProtKB:O00468-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O00468-1, Ser-496, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050652", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050652" } ] }, { "name": "agrin O-glycosylated 3 (human)", "definition": "An agrin (human) that has been O-glycosylated at the residue equivalent to Ser-896 of the amino acid sequence represented by UniProtKB:O00468-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O00468-1, Ser-896, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050653", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050653" } ] }, { "name": "agrin O-glycosylated 4 (human)", "definition": "An agrin (human) that has been O-glycosylated at the residue equivalent to Ser-994 of the amino acid sequence represented by UniProtKB:O00468-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:O00468-1, Ser-994, MOD:00002~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050654", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050654" } ] }, { "name": "agrin O-glycosylated 5 (human)", "definition": "An agrin (human) that has been O-glycosylated at the residue equivalent to Ser-994 of the amino acid sequence represented by UniProtKB:O00468-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O00468-1, Ser-994, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050655", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050655" } ] }, { "name": "agrin O-glycosylated 6 (human)", "definition": "An agrin (human) that has been O-glycosylated at the residue equivalent to Thr-1095 of the amino acid sequence represented by UniProtKB:O00468-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:O00468-1, Thr-1095, MOD:00005~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050656", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050656" } ] }, { "name": "agrin O-glycosylated 7 (human)", "definition": "An agrin (human) that has been O-glycosylated at the residue equivalent to Thr-1095 of the amino acid sequence represented by UniProtKB:O00468-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O00468-1, Thr-1095, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050657", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050657" } ] }, { "name": "agrin O-glycosylated 8 (human)", "definition": "An agrin (human) that has been O-glycosylated at the residue equivalent to Thr-1258 of the amino acid sequence represented by UniProtKB:O00468-1, in which the glycan composition is represented by GlyTouCan:G29063QY. Example: UniProtKB:O00468-1, Thr-1258, MOD:00005~GNO:G29063QY. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050658", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050658" } ] }, { "name": "agrin O-glycosylated 9 (human)", "definition": "An agrin (human) that has been O-glycosylated at the residue equivalent to Thr-1258 of the amino acid sequence represented by UniProtKB:O00468-1, in which the glycan composition is represented by GlyTouCan:G30190ML. Example: UniProtKB:O00468-1, Thr-1258, MOD:00005~GNO:G30190ML. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050659", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050659" } ] }, { "name": "agrin O-glycosylated 10 (human)", "definition": "An agrin (human) that has been O-glycosylated at the residue equivalent to Thr-1258 of the amino acid sequence represented by UniProtKB:O00468-1, in which the glycan composition is represented by GlyTouCan:G88713AC. Example: UniProtKB:O00468-1, Thr-1258, MOD:00005~GNO:G88713AC. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050660", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050660" } ] }, { "name": "agrin O-glycosylated 11 (human)", "definition": "An agrin (human) that has been O-glycosylated at the residue equivalent to Thr-1261 of the amino acid sequence represented by UniProtKB:O00468-1, in which the glycan composition is represented by GlyTouCan:G27391WQ. Example: UniProtKB:O00468-1, Thr-1261, MOD:00005~GNO:G27391WQ. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050661", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050661" } ] }, { "name": "agrin O-glycosylated 12 (human)", "definition": "An agrin (human) that has been O-glycosylated at the residue equivalent to Thr-1261 of the amino acid sequence represented by UniProtKB:O00468-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:O00468-1, Thr-1261, MOD:00005~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050662", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050662" } ] }, { "name": "agrin O-glycosylated 13 (human)", "definition": "An agrin (human) that has been O-glycosylated at the residue equivalent to Thr-1261 of the amino acid sequence represented by UniProtKB:O00468-1, in which the glycan composition is represented by GlyTouCan:G40740AD. Example: UniProtKB:O00468-1, Thr-1261, MOD:00005~GNO:G40740AD. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050663", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050663" } ] }, { "name": "agrin O-glycosylated 14 (human)", "definition": "An agrin (human) that has been O-glycosylated at the residue equivalent to Thr-1261 of the amino acid sequence represented by UniProtKB:O00468-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O00468-1, Thr-1261, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050664", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050664" } ] }, { "name": "agrin O-glycosylated 15 (human)", "definition": "An agrin (human) that has been O-glycosylated at the residue equivalent to Thr-1261 of the amino acid sequence represented by UniProtKB:O00468-1, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:O00468-1, Thr-1261, MOD:00005~GNO:G58001LT. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050665", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050665" } ] }, { "name": "agrin O-glycosylated 16 (human)", "definition": "An agrin (human) that has been O-glycosylated at the residue equivalent to Thr-1261 of the amino acid sequence represented by UniProtKB:O00468-1, in which the glycan composition is represented by GlyTouCan:G73004SD. Example: UniProtKB:O00468-1, Thr-1261, MOD:00005~GNO:G73004SD. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050666", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050666" } ] }, { "name": "agrin O-glycosylated 17 (human)", "definition": "An agrin (human) that has been O-glycosylated at the residue equivalent to Thr-1261 of the amino acid sequence represented by UniProtKB:O00468-1, in which the glycan composition is represented by GlyTouCan:G88713AC. Example: UniProtKB:O00468-1, Thr-1261, MOD:00005~GNO:G88713AC. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050667", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050667" } ] }, { "name": "agrin O-glycosylated 18 (human)", "definition": "An agrin (human) that has been O-glycosylated at the residue equivalent to Thr-159 of the amino acid sequence represented by UniProtKB:O00468-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O00468-1, Thr-159, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050668", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050668" } ] }, { "name": "agrin O-glycosylated 19 (human)", "definition": "An agrin (human) that has been O-glycosylated at the residue equivalent to Thr-162 of the amino acid sequence represented by UniProtKB:O00468-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:O00468-1, Thr-162, MOD:00005~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050669", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050669" } ] }, { "name": "agrin O-glycosylated 20 (human)", "definition": "An agrin (human) that has been O-glycosylated at the residue equivalent to Thr-162 of the amino acid sequence represented by UniProtKB:O00468-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O00468-1, Thr-162, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050670", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050670" } ] }, { "name": "agrin O-glycosylated 21 (human)", "definition": "An agrin (human) that has been O-glycosylated at the residue equivalent to Thr-167 of the amino acid sequence represented by UniProtKB:O00468-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O00468-1, Thr-167, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050671", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050671" } ] }, { "name": "agrin O-glycosylated 22 (human)", "definition": "An agrin (human) that has been O-glycosylated at the residue equivalent to Thr-985 of the amino acid sequence represented by UniProtKB:O00468-1, in which the glycan composition is represented by GlyTouCan:G29063QY. Example: UniProtKB:O00468-1, Thr-985, MOD:00005~GNO:G29063QY. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050672", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050672" } ] }, { "name": "agrin O-glycosylated 23 (human)", "definition": "An agrin (human) that has been O-glycosylated at the residue equivalent to Thr-985 of the amino acid sequence represented by UniProtKB:O00468-1, in which the glycan composition is represented by GlyTouCan:G57317CE. Example: UniProtKB:O00468-1, Thr-985, MOD:00005~GNO:G57317CE. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050673", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050673" } ] }, { "name": "agrin O-glycosylated 24 (human)", "definition": "An agrin (human) that has been O-glycosylated at the residue equivalent to Thr-987 of the amino acid sequence represented by UniProtKB:O00468-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:O00468-1, Thr-987, MOD:00005~GNO:G53434XO. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050674", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050674" } ] } ], "site_annotation": [ { "start_pos": 135, "end_pos": 137, "annotation": "n_glycosylation_sequon" }, { "start_pos": 250, "end_pos": 252, "annotation": "n_glycosylation_sequon" }, { "start_pos": 777, "end_pos": 779, "annotation": "n_glycosylation_sequon" }, { "start_pos": 932, "end_pos": 934, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [ 135, 250, 777, 932 ], "o_linked_sites": [ 145, 159, 162, 167, 204, 496, 754, 885, 896, 952, 980, 985, 987, 994, 1026, 1033, 1034, 1095, 1247, 1258, 1261, 1262, 1270, 1273, 1274, 1275, 1277, 1281, 1282, 1285, 1288, 1292, 1294, 1295, 1301, 1302, 1306, 1307, 1309, 1312, 1313, 1316, 1540, 1581, 1584, 1720, 1725, 1750, 1835, 1852, 1873, 1899, 1902, 1913 ], "snv_sites": [ 162, 496, 980, 1034, 1306, 1734, 1750, 1834 ], "glycation_sites": [], "phosphorylation_sites": [ 5, 674, 676 ], "sequon_annotation_sites": [ { "start_pos": 135, "end_pos": 137 }, { "start_pos": 250, "end_pos": 252 }, { "start_pos": 777, "end_pos": 779 }, { "start_pos": 932, "end_pos": 934 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 95 }, { "field": "total_sites", "count": 50 }, { "field": "n_linked_glycans", "count": 17 }, { "field": "n_linked_glycan_sites", "count": 8 }, { "field": "o_linked_glycans", "count": 13 }, { "field": "o_linked_glycan_sites", "count": 46 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 4 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 90 }, { "field": "total_sites", "count": 49 }, { "field": "n_linked_glycans", "count": 17 }, { "field": "n_linked_glycan_sites", "count": 4 }, { "field": "o_linked_glycans", "count": 13 }, { "field": "o_linked_glycan_sites", "count": 45 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 14 }, { "field": "total_sites", "count": 8 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 9 }, { "field": "total_sites", "count": 7 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 306 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }