{ "uniprot_canonical_ac": "O00338-1", "uniprot_ac": "O00338", "uniprot_id": "ST1C2_HUMAN", "mass": { "chemical_mass": 34880.0, "monoisotopic_mass": 34880.0 }, "refseq": { "ac": "NP_001047", "name": "sulfotransferase 1C2 isoform a", "summary": "Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001047" }, "gene_names": [ { "name": "SULT1C2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O00338", "id": "O00338" }, { "name": "SULT1C1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O00338", "id": "O00338" }, { "name": "SULT1C2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001047", "id": "NP_001047" }, { "name": "humSULTC2; ST1C1; ST1C2; SULT1C1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001047", "id": "NP_001047" } ], "protein_names": [ { "name": "Sulfotransferase 1C2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O00338" }, { "name": "2.8.2.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00338" }, { "name": "ST1C2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00338" }, { "name": "SULT1C#1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00338" }, { "name": "Sulfotransferase 1C1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00338" }, { "name": "humSULTC2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00338" }, { "name": "sulfotransferase 1C2 isoform a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001047", "id": "NP_001047" }, { "name": "sulfotransferase family, cytosolic, 1C, member 1; sulfotransferase 1C2; sulfotransferase 1C1; SULT1C#1; sulfotransferase family, cytosolic, 1C, member 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001047", "id": "NP_001047" } ], "function": [ { "annotation": "Our findings are the first to characterize the regulation of human SULT1C2 and SULT1C3 expression by several transcription factor activators.", "evidence": [ { "database": "RefSeq", "id": "NP_001047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001047" }, { "database": "PubMed", "id": "24335393", "url": "https://glygen.org/publication/PubMed/24335393" } ] }, { "annotation": "Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001047" } ] }, { "annotation": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic compounds. Does not sulfonate steroids, dopamine, acetaminophen, or alpha-naphthol (PubMed:9852044, PubMed:10783263, PubMed:10481272). Catalyzes the sulfonation of the carcinogenic N-Hydroxy-2-acetylaminofluorene leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed:9852044).", "evidence": [ { "database": "UniProtKB", "id": "O00338", "url": "https://www.uniprot.org/uniprot/O00338#function" }, { "database": "PubMed", "id": "10481272", "url": "https://glygen.org/publication/PubMed/10481272" }, { "database": "PubMed", "id": "9852044", "url": "https://glygen.org/publication/PubMed/9852044" }, { "database": "PubMed", "id": "10783263", "url": "https://glygen.org/publication/PubMed/10783263" } ] }, { "annotation": "The Sulfotransferase SULT1C2 Is Epigenetically Activated and Transcriptionally Induced by Tobacco Exposure and Is Associated with Patient Outcome in Lung Adenocarcinoma. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001047" }, { "database": "PubMed", "id": "35010676", "url": "https://glygen.org/publication/PubMed/35010676" } ] }, { "annotation": "Vitamin D receptor can interact directly with the SULT1C2 VDRE sequence to transcriptionally regulation SULT1C2 expression in colorectal tumor cells.", "evidence": [ { "database": "RefSeq", "id": "NP_001047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001047" }, { "database": "PubMed", "id": "27130351", "url": "https://glygen.org/publication/PubMed/27130351" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "O00338", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O00338" } ], "glycoeffect": [], "start_pos": 241, "end_pos": 241, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "C", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "2", "chr_pos": "108305538", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "R241", "disease": [ { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ] }, { "disease_id": "DOID:1115", "recommended_name": { "id": "DOID:1115", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1115", "name": "sarcoma", "description": "A cell type cancer that has_material_basis_in abnormally proliferating cells derives from embryonic mesoderm." }, "synonyms": [ { "id": "DOID:1115", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1115", "name": "connective and soft tissue neoplasm", "description": "" }, { "id": "DOID:1115", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1115", "name": "tumor of soft tissue and skeleton", "description": "" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs138809204", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs138809204" }, { "id": "rs138809204", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs138809204" }, { "id": "rs138809204", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs138809204#frequency_tab" }, { "id": "rs138809204", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs138809204" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 4, "end_pos": 4, "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->I).", "chr_id": "2", "chr_pos": "108293678", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T4", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "95.65", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000198203", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198203" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "42.45", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000198203", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198203" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "92.58", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000198203", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198203" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "49.96", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000198203", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198203" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "57.13", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000198203", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198203" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "79.89", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000198203", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198203" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "47.76", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000198203", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198203" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "57.27", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000198203", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198203" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "89.34", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000198203", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198203" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "47.6", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000198203", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198203" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "62.11", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000198203", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198203" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "58.51", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000198203", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198203" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "55.14", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000198203", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198203" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O00338", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00338" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O00338", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00338" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "O00338", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00338" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "O00338", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00338" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "O00338", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00338" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "O00338", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00338" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O00338", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00338" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "O00338", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00338" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "O00338", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00338" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Uterine cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:363", "evidence": [ { "database": "BioXpress", "id": "O00338", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00338" } ], "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Esophageal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:5041", "evidence": [ { "database": "BioXpress", "id": "O00338", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00338" } ], "disease": [ { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Aerodigestive tract cancer, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Escc, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "gastric cardia adenocarcinoma, susceptibility to", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Colorectal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:9256", "evidence": [ { "database": "BioXpress", "id": "O00338", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00338" } ], "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O00338", "url": "https://www.uniprot.org/uniprot/O00338" } ], "common_name": "Human" } ], "gene": [ { "name": "SULT1C2", "url": "https://www.uniprot.org/uniprot/O00338", "locus": { "chromosome": "2", "start_pos": 108309915, "end_pos": 108288639, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000198203", "url": "https://www.ensembl.org/id/ENSG00000198203" } ] } } ], "crossref": [ { "id": "ENSG00000198203", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198203", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "O00338", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O00338", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "CHEMBL1743295", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL1743295", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "SULT1C2", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=SULT1C2", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "6819", "url": "https://www.ncbi.nlm.nih.gov/gene/6819", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "11456", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=11456", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "O00338", "url": "https://www.ebi.ac.uk/intact/interactors/id:O00338*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000863", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000863", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:6819", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:6819", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "602385", "url": "http://www.omim.org/entry/602385", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O00338", "url": "https://www.nextprot.org/entry/NX_O00338", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "O00338", "url": "https://oglcnac.org/atlas/detail/O00338", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "O00338", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00338", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "PFIEWAQ", "url": "https://omabrowser.org/oma/group/PFIEWAQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3083090at2759", "url": "http://www.orthodb.org/?query=3083090at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11783", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11783", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11783:SF73", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11783:SF73", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "3BFX", "url": "https://www.rcsb.org/structure/3BFX", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00685", "url": "http://pfam.xfam.org/family/PF00685", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O00338", "url": "https://pharos.nih.gov/targets/O00338", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O00338", "url": "http://purl.obolibrary.org/obo/PR_O00338", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001047", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "12164", "url": "https://www.rhea-db.org/rhea/12164", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "B4DLP0", "url": "https://www.uniprot.org/uniprot/B4DLP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B4DLP0-1", "url": "https://www.uniprot.org/uniprot/B4DLP0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B8ZZF7", "url": "https://www.uniprot.org/uniprot/B8ZZF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B8ZZF7-1", "url": "https://www.uniprot.org/uniprot/B8ZZF7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9JSR0", "url": "https://www.uniprot.org/uniprot/C9JSR0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9JSR0-1", "url": "https://www.uniprot.org/uniprot/C9JSR0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7BZ17", "url": "https://www.uniprot.org/uniprot/H7BZ17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7BZ17-1", "url": "https://www.uniprot.org/uniprot/H7BZ17-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7C420", "url": "https://www.uniprot.org/uniprot/H7C420", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7C420-1", "url": "https://www.uniprot.org/uniprot/H7C420-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00338", "url": "https://www.uniprot.org/uniprot/O00338", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00338-1", "url": "https://www.uniprot.org/uniprot/O00338-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O00338-2", "url": "https://www.uniprot.org/uniprot/O00338-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALTSDLGKQIKLKEVEGTLLQPATVDNWSQIQSFEAKPDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRAIIQHRHPFIEWARPPQPSGVEKAKAMPSPRILKTHLSTQLLPPSFWENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWEMKDRHQILFLFYEDIKRDPKHEIRKVMQFMGKKVDETVLDKIVQETSFEKMKENPMTNRSTVSKSILDQSISSFMRKGTVGDWKNHFTVAQNERFDEIYRRKMEGTSINFCMEL", "length": 296, "header": "sp|O00338-1|ST1C2_HUMAN Isoform 1 of Sulfotransferase 1C2 OS=Homo sapiens OX=9606 GN=SULT1C2 PE=1 SV=1 CANONICAL=O00338-1" }, "isoforms": [ { "isoform_ac": "B4DLP0-1", "url": "", "sequence": { "sequence": "MALTSDLGKQIKLKEVEGTLLQPATVDNWSQIQSFEAKPDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRAIIQHRHPFIEWARPPQPSVLVLRRCFLLSYFKGVEKAKAMPSPRILKTHLSTQLLPPSFWENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWEMKDRHQILFLFYEDIKRDPKHEIRKVMQFMGKKVDETVLDKIVQETSFEKMKENPMTNRSTVSKSILDQSISSFMRKGTVGDWKNHFTVAQNERFDEIYRRKMEGTSINFCMEL", "length": 310, "header": "tr|B4DLP0-1|B4DLP0_HUMAN Computationally mapped isoform of Sulfotransferase OS=Homo sapiens OX=9606 GN=SULT1C2 PE=1 SV=1 CANONICAL=O00338-1" }, "locus": { "chromosome": "2", "start_pos": 108308461, "end_pos": 108293668, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000437390.6", "url": "https://www.ensembl.org/id/ENST00000437390.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000399651.2", "url": "https://www.ensembl.org/id/ENSP00000399651.2" } ] } }, { "isoform_ac": "B8ZZF7-1", "url": "", "sequence": { "sequence": "MALTSDLGKQIKLKEVEGTLLQPATVDNWSQIQSFEAKPDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRAIIQHRHPFIEWARPPQPSARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWEMKDRHQILFLFYEDIKRDPKHEIRKVMQFMGKKVDETVLDKIVQETSFEKMKENPMTNRSTVSKSILDQSISSFMRKGTVGDWKNHFTVAQNERFDEIYRRKMEGTSINFCMEL", "length": 259, "header": "tr|B8ZZF7-1|B8ZZF7_HUMAN Computationally mapped isoform of Sulfotransferase OS=Homo sapiens OX=9606 GN=SULT1C2 PE=1 SV=1 CANONICAL=O00338-1" }, "locus": { "chromosome": "2", "start_pos": 108308461, "end_pos": 108293668, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000409880.5", "url": "https://www.ensembl.org/id/ENST00000409880.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000387054.1", "url": "https://www.ensembl.org/id/ENSP00000387054.1" } ] } }, { "isoform_ac": "C9JSR0-1", "url": "", "sequence": { "sequence": "MALTSDLGKQIKLKEVEGTLLQPATVDNWSQIQSFEAKPDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRAIIQHRHPFIEWARPPQPSAAATVFLGKQLQVPLCSSKCQRLYGFLLPFPKDEPHAS", "length": 130, "header": "tr|C9JSR0-1|C9JSR0_HUMAN Computationally mapped isoform of Sulfotransferase OS=Homo sapiens OX=9606 GN=SULT1C2 PE=1 SV=1 CANONICAL=O00338-1" }, "locus": { "chromosome": "2", "start_pos": 108304650, "end_pos": 108293668, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000438339.5", "url": "https://www.ensembl.org/id/ENST00000438339.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000401996.1", "url": "https://www.ensembl.org/id/ENSP00000401996.1" } ] } }, { "isoform_ac": "H7BZ17-1", "url": "", "sequence": { "sequence": "XSDLGKQIKLKEVEGTLLQPATVDNWSQIQSFEAKPDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRAIIQHRHPFIEWARPPQPSGVEKAKAMPSPRILKTHLSTQLLPPSFWENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWEMKDRHQILFLFYEDIKRELWGIGKTTSLLPRMRGLMKSIEERWKEPP", "length": 226, "header": "tr|H7BZ17-1|H7BZ17_HUMAN Computationally mapped isoform of Sulfotransferase OS=Homo sapiens OX=9606 GN=SULT1C2 PE=1 SV=1 CANONICAL=O00338-1" }, "locus": { "chromosome": "2", "start_pos": 108308443, "end_pos": 108293679, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000409067.2", "url": "https://www.ensembl.org/id/ENST00000409067.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000387340.2", "url": "https://www.ensembl.org/id/ENSP00000387340.2" } ] } }, { "isoform_ac": "H7C420-1", "url": "", "sequence": { "sequence": "XTSDLGKQIKLKEVEGTLLQPATVDNWSQIQSFEAKPDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRAIIQHRHPFIEWARPPQPSVPLCSSKCQRLYGFLLPFPKDEPHAS", "length": 116, "header": "tr|H7C420-1|H7C420_HUMAN Computationally mapped isoform of Sulfotransferase OS=Homo sapiens OX=9606 GN=SULT1C2 PE=1 SV=1 CANONICAL=O00338-1" }, "locus": { "chromosome": "2", "start_pos": 108304652, "end_pos": 108293676, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000442801.5", "url": "https://www.ensembl.org/id/ENST00000442801.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000415194.1", "url": "https://www.ensembl.org/id/ENSP00000415194.1" } ] } }, { "isoform_ac": "O00338-1", "url": "", "sequence": { "sequence": "MALTSDLGKQIKLKEVEGTLLQPATVDNWSQIQSFEAKPDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRAIIQHRHPFIEWARPPQPSGVEKAKAMPSPRILKTHLSTQLLPPSFWENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWEMKDRHQILFLFYEDIKRDPKHEIRKVMQFMGKKVDETVLDKIVQETSFEKMKENPMTNRSTVSKSILDQSISSFMRKGTVGDWKNHFTVAQNERFDEIYRRKMEGTSINFCMEL", "length": 296, "header": "sp|O00338-1|ST1C2_HUMAN Isoform 1 of Sulfotransferase 1C2 OS=Homo sapiens OX=9606 GN=SULT1C2 PE=1 SV=1 CANONICAL=O00338-1" }, "locus": { "chromosome": "2", "start_pos": 108308461, "end_pos": 108293668, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000251481.11", "url": "https://www.ensembl.org/id/ENST00000251481.11" }, { "database": "Ensembl Peptide", "id": "ENSP00000251481.6", "url": "https://www.ensembl.org/id/ENSP00000251481.6" } ] } }, { "isoform_ac": "O00338-2", "url": "", "sequence": { "sequence": "MALTSDLGKQIKLKEVEGTLLQPATVDNWSQIQSFEAKPDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRAIIQHRHPFIEWARPPQPSETGFHHVAQAGLKLLSSSNPPASTSQSAKITDLLPPSFWENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWEMKDRHQILFLFYEDIKRDPKHEIRKVMQFMGKKVDETVLDKIVQETSFEKMKENPMTNRSTVSKSILDQSISSFMRKGTVGDWKNHFTVAQNERFDEIYRRKMEGTSINFCMEL", "length": 307, "header": "sp|O00338-2|ST1C2_HUMAN Isoform 2 of Sulfotransferase 1C2 OS=Homo sapiens OX=9606 GN=SULT1C2 PE=1 SV=1 CANONICAL=O00338-1" }, "locus": { "chromosome": "2", "start_pos": 108308461, "end_pos": 108293668, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000326853.9", "url": "https://www.ensembl.org/id/ENST00000326853.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000319622.5", "url": "https://www.ensembl.org/id/ENSP00000319622.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 4, "start_aa": "Thr", "end_pos": 4, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr4", "evidence": [ { "id": "O00338", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00338" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "O00338", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O00338" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 5, "start_aa": "Ser", "end_pos": 5, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser5", "evidence": [ { "id": "O00338", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O00338" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" } ] } ], "phosphorylation": [ { "start_pos": 139, "end_pos": 139, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O00338", "url": "https://www.uniprot.org/uniprot/O00338" } ], "site_lbl": "Ser139" }, { "start_pos": 254, "end_pos": 254, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O00338", "url": "https://www.uniprot.org/uniprot/O00338" } ], "site_lbl": "Ser254" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Characterization of human iodothyronine sulfotransferases.", "journal": "The Journal of clinical endocrinology and metabolism", "date": "1999", "authors": "Kester MH, Kaptein E, Roest TJ, van Dijk CH, Tibboel D, Meinl W, Glatt H, Coughtrie MW, Visser TJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "10199779", "url": "https://glygen.org/publication/PubMed/10199779" } ] }, { "title": "Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Spiegelberg BD, Xiong JP, Smith JJ, Gu RF, York JD", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "10224133", "url": "https://glygen.org/publication/PubMed/10224133" } ] }, { "title": "Molecular cloning, expression, localisation and functional characterisation of a rabbit SULT1C2 sulfotransferase.", "journal": "The international journal of biochemistry & cell biology", "date": "1999-08", "authors": "Hehonah N, Zhu X, Brix L, Bolton-Grob R, Barnett A, Windmill K, McManus M", "evidence": [ { "database": "UniProtKB", "id": "O00338", "url": "https://www.uniprot.org/uniprot/O00338" } ], "reference": [ { "type": "PubMed", "id": "10481272", "url": "https://glygen.org/publication/PubMed/10481272" } ] }, { "title": "Sulfotransferase catalyzing sulfation of heterocyclic amines.", "journal": "Cancer letters", "date": "1999", "authors": "Yamazoe Y, Nagata K, Yoshinari K, Fujita K, Shiraga T, Iwasaki K", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "10503886", "url": "https://glygen.org/publication/PubMed/10503886" } ] }, { "title": "Sulfation of iodothyronines by recombinant human liver steroid sulfotransferases.", "journal": "Biochemical and biophysical research communications", "date": "1999", "authors": "Li X, Anderson RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "10512730", "url": "https://glygen.org/publication/PubMed/10512730" } ] }, { "title": "Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization.", "journal": "Genomics", "date": "2000-04-15", "authors": "Freimuth R R, Raftogianis R B, Wood T C, Moon E, Kim U J, Xu J, Siciliano M J, Weinshilboum R M", "evidence": [ { "database": "UniProtKB", "id": "O00338", "url": "https://www.uniprot.org/uniprot/O00338" } ], "reference": [ { "type": "PubMed", "id": "10783263", "url": "https://glygen.org/publication/PubMed/10783263" } ] }, { "title": "Sulfation of iodothyronines by human sulfotransferase 1C1 (SULT1C1)*.", "journal": "Biochemical pharmacology", "date": "2000", "authors": "Li X, Clemens DL, Anderson RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "11077054", "url": "https://glygen.org/publication/PubMed/11077054" } ] }, { "title": "Sulfotransferases in the bioactivation of xenobiotics.", "journal": "Chemico-biological interactions", "date": "2000", "authors": "Glatt H", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "11154739", "url": "https://glygen.org/publication/PubMed/11154739" } ] }, { "title": "Expression and characterization of the human 3 beta-hydroxysteroid sulfotransferases (SULT2B1a and SULT2B1b).", "journal": "The Journal of steroid biochemistry and molecular biology", "date": "2001", "authors": "Meloche CA, Falany CN", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "11457664", "url": "https://glygen.org/publication/PubMed/11457664" } ] }, { "title": "Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate.", "journal": "The Journal of endocrinology", "date": "2001", "authors": "Li X, Clemens DL, Cole JR, Anderson RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "11739018", "url": "https://glygen.org/publication/PubMed/11739018" } ] }, { "title": "Highly conserved mouse and human brain sulfotransferases: molecular cloning, expression, and functional characterization.", "journal": "Gene", "date": "2002", "authors": "Sakakibara Y, Suiko M, Pai TG, Nakayama T, Takami Y, Katafuchi J, Liu MC", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "12039030", "url": "https://glygen.org/publication/PubMed/12039030" } ] }, { "title": "Mutational analysis of human hydroxysteroid sulfotransferase SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces cholesterol sulfotransferase, whereas exon 1A yields pregnenolone sulfotransferase.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Fuda H, Lee YC, Shimizu C, Javitt NB, Strott CA", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "12145317", "url": "https://glygen.org/publication/PubMed/12145317" } ] }, { "title": "Sulfonation and molecular action.", "journal": "Endocrine reviews", "date": "2002", "authors": "Strott CA", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "12372849", "url": "https://glygen.org/publication/PubMed/12372849" } ] }, { "title": "Endoglycan, a member of the CD34 family, functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Fieger CB, Sassetti CM, Rosen SD", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "12889478", "url": "https://glygen.org/publication/PubMed/12889478" } ] }, { "title": "Human catecholamine sulfotransferase (SULT1A3) pharmacogenetics: functional genetic polymorphism.", "journal": "Journal of neurochemistry", "date": "2003", "authors": "Thomae BA, Rifki OF, Theobald MA, Eckloff BW, Wieben ED, Weinshilboum RM", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "14622112", "url": "https://glygen.org/publication/PubMed/14622112" } ] }, { "title": "The crystal structure of CCG1/TAF(II)250-interacting factor B (CIB).", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Padmanabhan B, Kuzuhara T, Adachi N, Horikoshi M", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "14672934", "url": "https://glygen.org/publication/PubMed/14672934" } ] }, { "title": "Human SULT1A3 pharmacogenetics: gene duplication and functional genomic studies.", "journal": "Biochemical and biophysical research communications", "date": "2004", "authors": "Hildebrandt MA, Salavaggione OE, Martin YN, Flynn HC, Jalal S, Wieben ED, Weinshilboum RM", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "15358107", "url": "https://glygen.org/publication/PubMed/15358107" } ] }, { "title": "Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP).", "journal": "Proteins", "date": "2006", "authors": "Dombrovski L, Dong A, Bochkarev A, Plotnikov AN", "evidence": [ { "database": "UniProtKB", "id": "O00338", "url": "https://www.uniprot.org/uniprot/O00338" } ], "reference": [ { "type": "PubMed", "id": "16804942", "url": "https://glygen.org/publication/PubMed/16804942" } ] }, { "title": "Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2008", "authors": "Kerr SC, Fieger CB, Snapp KR, Rosen SD", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "18606703", "url": "https://glygen.org/publication/PubMed/18606703" } ] }, { "title": "Mass spectrometric kinetic analysis of human tyrosylprotein sulfotransferase-1 and -2.", "journal": "Journal of the American Society for Mass Spectrometry", "date": "2008", "authors": "Danan LM, Yu Z, Hoffhines AJ, Moore KL, Leary JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "18672380", "url": "https://glygen.org/publication/PubMed/18672380" } ] }, { "title": "Human liver steroid sulphotransferase sulphates bile acids.", "journal": "The Biochemical journal", "date": "1990", "authors": "Radominska A, Comer KA, Zimniak P, Falany J, Iscan M, Falany CN", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "2268288", "url": "https://glygen.org/publication/PubMed/2268288" } ] }, { "title": "Role for cytoplasmic nucleotide hydrolysis in hepatic function and protein synthesis.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2013", "authors": "Hudson BH, Frederick JP, Drake LY, Megosh LC, Irving RP, York JD", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "23479625", "url": "https://glygen.org/publication/PubMed/23479625" } ] }, { "title": "Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction.", "journal": "Nature communications", "date": "2013", "authors": "Teramoto T, Fujikawa Y, Kawaguchi Y, Kurogi K, Soejima M, Adachi R, Nakanishi Y, Mishiro-Sato E, Liu MC, Sakakibara Y, Suiko M, Kimura M, Kakuta Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "23481380", "url": "https://glygen.org/publication/PubMed/23481380" } ] }, { "title": "Regulation of human cytosolic sulfotransferases 1C2 and 1C3 by nuclear signaling pathways in LS180 colorectal adenocarcinoma cells.", "journal": "Drug metabolism and disposition: the biological fate of chemicals", "date": "2014", "authors": "Rondini EA, Fang H, Runge-Morris M, Kocarek TA", "evidence": [ { "database": "RefSeq", "id": "NP_001047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001047" } ], "reference": [ { "type": "PubMed", "id": "24335393", "url": "https://glygen.org/publication/PubMed/24335393" } ] }, { "title": "Transcriptional Regulation of Cytosolic Sulfotransferase 1C2 by Vitamin D Receptor in LS180 Human Colorectal Adenocarcinoma Cells.", "journal": "Drug metabolism and disposition: the biological fate of chemicals", "date": "2016", "authors": "Barrett KG, Fang H, Kocarek TA, Runge-Morris M", "evidence": [ { "database": "RefSeq", "id": "NP_001047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001047" } ], "reference": [ { "type": "PubMed", "id": "27130351", "url": "https://glygen.org/publication/PubMed/27130351" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "O00338", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O00338" }, { "database": "O-GlcNAc Atlas", "id": "O00338", "url": "https://oglcnac.org/atlas/detail/O00338" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "The Sulfotransferase SULT1C2 Is Epigenetically Activated and Transcriptionally Induced by Tobacco Exposure and Is Associated with Patient Outcome in Lung Adenocarcinoma.", "journal": "International journal of environmental research and public health", "date": "2021", "authors": "Johnson C, Mullen DJ, Selamat SA, Campan M, Offringa IA, Marconett CN", "evidence": [ { "database": "RefSeq", "id": "NP_001047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001047" } ], "reference": [ { "type": "PubMed", "id": "35010676", "url": "https://glygen.org/publication/PubMed/35010676" } ] }, { "title": "Thermolabile and thermostable human platelet phenol sulfotransferase. Substrate specificity and physical separation.", "journal": "Naunyn-Schmiedeberg's archives of pharmacology", "date": "1983", "authors": "Reiter C, Mwaluko G, Dunnette J, Van Loon J, Weinshilboum R", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "6139755", "url": "https://glygen.org/publication/PubMed/6139755" } ] }, { "title": "Radioenzymatic assay of sulfate conjugates of catecholamines and DOPA in plasma.", "journal": "Life sciences", "date": "1980", "authors": "Johnson GA, Baker CA, Smith RT", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "6770210", "url": "https://glygen.org/publication/PubMed/6770210" } ] }, { "title": "Cloning and expression of human liver dehydroepiandrosterone sulphotransferase.", "journal": "The Biochemical journal", "date": "1993", "authors": "Comer KA, Falany JL, Falany CN", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "7678732", "url": "https://glygen.org/publication/PubMed/7678732" } ] }, { "title": "Bacterial expression and characterization of a cDNA for human liver estrogen sulfotransferase.", "journal": "The Journal of steroid biochemistry and molecular biology", "date": "1995", "authors": "Falany CN, Krasnykh V, Falany JL", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "7779757", "url": "https://glygen.org/publication/PubMed/7779757" } ] }, { "title": "Human liver estrogen sulfotransferase: identification by cDNA cloning and expression.", "journal": "Biochemical and biophysical research communications", "date": "1994", "authors": "Aksoy IA, Wood TC, Weinshilboum R", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "8185618", "url": "https://glygen.org/publication/PubMed/8185618" } ] }, { "title": "cDNA cloning and expression of a new form of human aryl sulfotransferase.", "journal": "The international journal of biochemistry & cell biology", "date": "1996", "authors": "Zhu X, Veronese ME, Iocco P, McManus ME", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "8697101", "url": "https://glygen.org/publication/PubMed/8697101" } ] }, { "title": "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes.", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "date": "1997", "authors": "Weinshilboum RM, Otterness DM, Aksoy IA, Wood TC, Her C, Raftogianis RB", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "9034160", "url": "https://glygen.org/publication/PubMed/9034160" } ] }, { "title": "Human sulfotransferase SULT1C1: cDNA cloning, tissue-specific expression, and chromosomal localization.", "journal": "Genomics", "date": "1997", "authors": "Her C, Kaur GP, Athwal RS, Weinshilboum RM", "evidence": [ { "database": "UniProtKB", "id": "O00338", "url": "https://www.uniprot.org/uniprot/O00338" } ], "reference": [ { "type": "PubMed", "id": "9169148", "url": "https://glygen.org/publication/PubMed/9169148" } ] }, { "title": "Expression and characterization of a novel thyroid hormone-sulfating form of cytosolic sulfotransferase from human liver.", "journal": "Molecular pharmacology", "date": "1998", "authors": "Wang J, Falany JL, Falany CN", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "9463486", "url": "https://glygen.org/publication/PubMed/9463486" } ] }, { "title": "Tyrosylprotein sulfotransferase: purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common posttranslational modification of eukaryotic proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1998", "authors": "Ouyang Yb, Lane WS, Moore KL", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "9501187", "url": "https://glygen.org/publication/PubMed/9501187" } ] }, { "title": "Structural and functional characterisation of human sulfotransferases.", "journal": "Chemico-biological interactions", "date": "1998", "authors": "Brix LA, Nicoll R, Zhu X, McManus ME", "evidence": [ { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "9566739", "url": "https://glygen.org/publication/PubMed/9566739" } ] }, { "title": "Molecular characterization of ST1C1-related human sulfotransferase.", "journal": "Carcinogenesis", "date": "1998", "authors": "Yoshinari K, Nagata K, Shimada M, Yamazoe Y", "evidence": [ { "database": "UniProtKB", "id": "O00338", "url": "https://www.uniprot.org/uniprot/O00338" } ], "reference": [ { "type": "PubMed", "id": "9635888", "url": "https://glygen.org/publication/PubMed/9635888" } ] }, { "title": "Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2-acetylaminofluorene.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Sakakibara Y, Yanagisawa K, Katafuchi J, Ringer DP, Takami Y, Nakayama T, Suiko M, Liu MC", "evidence": [ { "database": "UniProtKB", "id": "O00338", "url": "https://www.uniprot.org/uniprot/O00338" }, { "database": "Reactome", "id": "R-HSA-156584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584" } ], "reference": [ { "type": "PubMed", "id": "9852044", "url": "https://glygen.org/publication/PubMed/9852044" } ] } ], "pathway": [ { "id": "hsa:6819", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:6819", "resource": "KEGG Pathway" }, { "id": "R-HSA-156584", "name": "Cytosolic sulfonation of small molecules", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156584", "resource": "Reactome", "description": "Cytosolic sulfonation of small molecules" } ], "orthologs": [ { "uniprot_canonical_ac": "Q9D939-1", "protein_name": "Sulfotransferase 1C2", "gene_name": "Sult1c2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALTPELSRQTKLKEVAGIPLQAPTVDNWRQIQTFEAKPDDLLICTYPKSGTTWIQEIVDMIEQNGDVEKCRRTIIQHRHPFIEWARPPQPSGVDKANEMPAPRILRTHLPTQLLPPSFWTNNCKFLYVARNAKDCMVSYYHFYRMSQVLPEPGTWDEYFETFINGKVSWGSWFDHVKGWWEIRDKYQILFLFYEDMKRNPKHEIQKVMQFMGKNLDEDVVDKIVLETSFEKMKENPMTNRSTAPKSILDQSISPFMRKGTVGDWKNHFTVAQNERFDEIYKQKMGRTSLNFSMEL", "length": 296 }, "evidence": [ { "id": "45919732", "url": "http://www.informatics.jax.org/homology/45919732", "database": "MGI" }, { "id": "O00338", "url": "https://omabrowser.org/oma/group/O00338/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9WUW8-1", "protein_name": "Sulfotransferase 1C2", "gene_name": "Sult1c2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALAPELSRQTKLKEVAGIPLQAPTVDNWSQIQTFKAKPDDLLICTYPKSGTTWIQEIVDMIEQNGDVEKCQRTIIQHRHPFIEWARPPQPSGVDKANAMPAPRILRTHLPTQLLPPSFWTNNCKFLYVARNAKDCMVSYYHFYRMSQVLPDPGTWNEYFETFINGKVSWGSWFDHVKGWWEIRDRYQILFLFYEDMKRDPKREIQKVMQFMGKNLDEEVVDKIVLETSFEKMKENPMTNRSTVPKSVLDQSISPFMRKGTVGDWKNHFTVAQNDRFDEIYKQKMGGTSLNFCMEL", "length": 296 }, "evidence": [ { "id": "45919732", "url": "http://www.informatics.jax.org/homology/45919732", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9WUW9-1", "protein_name": "Sulfotransferase 1C2A", "gene_name": "Sult1c2a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALAPELSRQTKLKEVAGIPLMDPTVNNWSQIQTFKAKPDDLLICTYPKSGTTWIQEIVNMIEQNGDVEKCQRTIIQHRHPVIEWARPPQPSGVDKANAMPAPRILRTHLPPQLLPPSFWTNNCKYLYVARNAKDCMVSYYHFYRMCQVLPNPGTWNEYFETFINGKVSWGSWFDHVKGWWEIRDRYQILFLFYEDMKRDPKREIQKVMQFMGKNLDEEVVDKIVLETSFEKMKDNPLTNFSTIPKTIMDQSISPFMRKGIVGDWKNHFTVAQNERFDEIYEQKMDGTSLNFCMEL", "length": 296 }, "evidence": [ { "id": "45919732", "url": "http://www.informatics.jax.org/homology/45919732", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "sulfotransferase activity", "id": "GO:0008146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008146", "evidence": [ { "database": "UniProtKB", "id": "O00338", "url": "https://www.uniprot.org/uniprot/O00338" } ], "pmid": "" }, { "name": "aryl sulfotransferase activity", "id": "GO:0004062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004062", "evidence": [ { "database": "UniProtKB", "id": "O00338", "url": "https://www.uniprot.org/uniprot/O00338" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "sulfation", "id": "GO:0051923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051923", "evidence": [ { "database": "UniProtKB", "id": "O00338", "url": "https://www.uniprot.org/uniprot/O00338" } ], "pmid": "" }, { "name": "amine metabolic process", "id": "GO:0009308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009308", "evidence": [ { "database": "UniProtKB", "id": "O00338", "url": "https://www.uniprot.org/uniprot/O00338" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O00338", "url": "https://www.uniprot.org/uniprot/O00338" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O00338", "url": "https://www.uniprot.org/uniprot/O00338" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "O00338", "url": "https://www.uniprot.org/uniprot/O00338" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 240, "end_pos": 242, "annotation": "n_glycosylation_sequon" }, { "start_pos": 28, "end_pos": 30, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12164", "name": "", "equation": "3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P17988-1", "Q9WUW8-1", "Q9WUW9-1", "P52847-1", "A0A0G2JZU5-1", "A0A8I5ZKG4-1", "P0DMN0-1", "P50225-1", "P50226-1", "P0DMM9-1", "Q6IMI6-1", "O43704-1", "O75897-1", "O00338-1", "P52840-1", "Q9D939-1", "Q9QWG7-1" ], "evidence": [ { "id": "12164", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12164" } ] }, { "id": "R-HSA-176474", "name": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP", "equation": "", "summary": "Six SULT enzymes, SULT1A1 (Li et al. 2001), 1A3 (Kester, Kaptein et al. 1999), 1B1 (Wang et al. 1998), 1C1 (Li et al. 2000), 1E1 (Li and Anderson 1999; Kester, van Dijk et al. 1999), and 2A1 (Li and Anderson 1999), can catalyze the sulfonation of 3,3'-diiodothyronine (T2) in vitro or in tissue culture model systems. These six enzymes also catalyze the sulfonation of 3,5,3'-triiodothyronine (T3).", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-176486" ], "output_participant_list": [ "R-ALL-176519" ], "enzyme_list": [ "O43704-1", "P50225-1", "Q06520-1", "Q6IMI4-1", "P0DMM9-1", "P49888-1", "O00338-1" ], "evidence": [ { "id": "R-HSA-176474", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-176474" } ] }, { "id": "R-HSA-176585", "name": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP", "equation": "", "summary": "3,5,3'-Triiodothyronine (T3) 4-sulfate is a major metabolite of T3 in humans (LoPresti and Nicoloff 1994), and seven SULT enzymes, SULT1A1 (Li et al. 2001), 1A3 (Kester, Kaptein et al. 1999), 1B1 (Wang et al. 1998), 1C1 (Li et al. 2000), 1E1 (Li and Anderson 1999; Kester, van Dijk et al. 1999), 2A1 (Li and Anderson 1999), and 4A1 (Sakakibara et al. 2002) can catalyze this reaction in vitro or in tissue culture model systems. All of these enzymes except SULT4A1 also catalyze the sulfonation of 3,3'-diiodothyronine (T2).", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-176667" ], "output_participant_list": [ "R-ALL-176564" ], "enzyme_list": [ "O43704-1", "P50225-1", "Q06520-1", "Q9BR01-1", "Q6IMI4-1", "P0DMM9-1", "P49888-1", "O00338-1" ], "evidence": [ { "id": "R-HSA-176585", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-176585" } ] }, { "id": "R-HSA-176669", "name": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP", "equation": "", "summary": "Sulfonation of the xenobiotic N-hydroxy-2-acetylaminofluorene converts it to a potent carcinogen. SULT1A2 (Glatt 2000) and SULT1C1 and 1C2 (Sakakibara et al. 1998) catalyze this reaction.", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-176566" ], "output_participant_list": [ "R-ALL-176500" ], "enzyme_list": [ "O75897-1", "P50226-1", "O00338-1" ], "evidence": [ { "id": "R-HSA-176669", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-176669" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-176486", "participant_name": "3,3'-diiodothyronine [cytosol]", "crossref": [ { "id": "000045331653", "database": "ZINC", "url": "" }, { "id": "HMDB0005869", "database": "HMDB Metabolite", "url": "" }, { "id": "35430", "database": "ChEBI", "url": "" }, { "id": "000016051523", "database": "ZINC", "url": "" }, { "id": "HMDB0246002", "database": "HMDB Metabolite", "url": "" }, { "id": "11533682", "database": "PubChem Substance", "url": "" }, { "id": "35430", "database": "ChEBI", "url": "" }, { "id": "11533682", "database": "PubChem Substance", "url": "" }, { "id": "000045331653", "database": "ZINC", "url": "" }, { "id": "000016051523", "database": "ZINC", "url": "" }, { "id": "HMDB0005869", "database": "HMDB Metabolite", "url": "" }, { "id": "HMDB0246002", "database": "HMDB Metabolite", "url": "" }, { "id": "35430", "database": "ChEBI", "url": "" }, { "id": "11533682", "database": "PubChem Substance", "url": "" }, { "id": "000045331653", "database": "ZINC", "url": "" }, { "id": "000016051523", "database": "ZINC", "url": "" }, { "id": "HMDB0005869", "database": "HMDB Metabolite", "url": "" }, { "id": "HMDB0246002", "database": "HMDB Metabolite", "url": "" }, { "id": "000045331653", "database": "ZINC", "url": "" }, { "id": "HMDB0005869", "database": "HMDB Metabolite", "url": "" }, { "id": "35430", "database": "ChEBI", "url": "" }, { "id": "HMDB0246002", "database": "HMDB Metabolite", "url": "" }, { "id": "000016051523", "database": "ZINC", "url": "" }, { "id": "11533682", "database": "PubChem Substance", "url": "" }, { "id": "000045331653", "database": "ZINC", "url": "" }, { "id": "HMDB0005869", "database": "HMDB Metabolite", "url": "" }, { "id": "35430", "database": "ChEBI", "url": "" }, { "id": "11533682", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0246002", "database": "HMDB Metabolite", "url": "" }, { "id": "000016051523", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-176500", "participant_name": "AAF-N-S [cytosol]", "crossref": [ { "id": "35424", "database": "ChEBI", "url": "" }, { "id": "11533684", "database": "PubChem Substance", "url": "" }, { "id": "000002018271", "database": "ZINC", "url": "" }, { "id": "11533684", "database": "PubChem Substance", "url": "" }, { "id": "000002018271", "database": "ZINC", "url": "" }, { "id": "35424", "database": "ChEBI", "url": "" }, { "id": "11533684", "database": "PubChem Substance", "url": "" }, { "id": "35424", "database": "ChEBI", "url": "" }, { "id": "000002018271", "database": "ZINC", "url": "" }, { "id": "35424", "database": "ChEBI", "url": "" }, { "id": "11533684", "database": "PubChem Substance", "url": "" }, { "id": "000002018271", "database": "ZINC", "url": "" }, { "id": "35424", "database": "ChEBI", "url": "" }, { "id": "11533684", "database": "PubChem Substance", "url": "" }, { "id": "000002018271", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-176519", "participant_name": "3,3'-diiodothyronine 4-sulfate [cytosol]", "crossref": [ { "id": "35431", "database": "ChEBI", "url": "" }, { "id": "11533681", "database": "PubChem Substance", "url": "" }, { "id": "000031706818", "database": "ZINC", "url": "" }, { "id": "000031706818", "database": "ZINC", "url": "" }, { "id": "35431", "database": "ChEBI", "url": "" }, { "id": "11533681", "database": "PubChem Substance", "url": "" }, { "id": "35431", "database": "ChEBI", "url": "" }, { "id": "000031706818", "database": "ZINC", "url": "" }, { "id": "11533681", "database": "PubChem Substance", "url": "" }, { "id": "35431", "database": "ChEBI", "url": "" }, { "id": "11533681", "database": "PubChem Substance", "url": "" }, { "id": "000031706818", "database": "ZINC", "url": "" }, { "id": "35431", "database": "ChEBI", "url": "" }, { "id": "11533681", "database": "PubChem Substance", "url": "" }, { "id": "000031706818", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-176564", "participant_name": "3,5,3'-triiodothyronine 4-sulfate [cytosol]", "crossref": [ { "id": "35432", "database": "ChEBI", "url": "" }, { "id": "11533680", "database": "PubChem Substance", "url": "" }, { "id": "000085552312", "database": "ZINC", "url": "" }, { "id": "HMDB0003036", "database": "HMDB Metabolite", "url": "" }, { "id": "11533680", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0003036", "database": "HMDB Metabolite", "url": "" }, { "id": "35432", "database": "ChEBI", "url": "" }, { "id": "000085552312", "database": "ZINC", "url": "" }, { "id": "000085552312", "database": "ZINC", "url": "" }, { "id": "35432", "database": "ChEBI", "url": "" }, { "id": "11533680", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0003036", "database": "HMDB Metabolite", "url": "" }, { "id": "35432", "database": "ChEBI", "url": "" }, { "id": "11533680", "database": "PubChem Substance", "url": "" }, { "id": "000085552312", "database": "ZINC", "url": "" }, { "id": "HMDB0003036", "database": "HMDB Metabolite", "url": "" }, { "id": "35432", "database": "ChEBI", "url": "" }, { "id": "11533680", "database": "PubChem Substance", "url": "" }, { "id": "000085552312", "database": "ZINC", "url": "" }, { "id": "HMDB0003036", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-176566", "participant_name": "N-hydroxy-2-acetylaminofluorene [cytosol]", "crossref": [ { "id": "8145202", "database": "PubChem Substance", "url": "" }, { "id": "17931", "database": "ChEBI", "url": "" }, { "id": "000005196784", "database": "ZINC", "url": "" }, { "id": "HMDB0255151", "database": "HMDB Metabolite", "url": "" }, { "id": "17931", "database": "ChEBI", "url": "" }, { "id": "000005196784", "database": "ZINC", "url": "" }, { "id": "8145202", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0255151", "database": "HMDB Metabolite", "url": "" }, { "id": "17931", "database": "ChEBI", "url": "" }, { "id": "000005196784", "database": "ZINC", "url": "" }, { "id": "8145202", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0255151", "database": "HMDB Metabolite", "url": "" }, { "id": "17931", "database": "ChEBI", "url": "" }, { "id": "8145202", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0255151", "database": "HMDB Metabolite", "url": "" }, { "id": "000005196784", "database": "ZINC", "url": "" }, { "id": "8145202", "database": "PubChem Substance", "url": "" }, { "id": "17931", "database": "ChEBI", "url": "" }, { "id": "000005196784", "database": "ZINC", "url": "" }, { "id": "HMDB0255151", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-176667", "participant_name": "T3 [cytosol]", "crossref": [ { "id": "28774", "database": "ChEBI", "url": "" }, { "id": "2636", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "000004097418", "database": "ZINC", "url": "" }, { "id": "000004097417", "database": "ZINC", "url": "" }, { "id": "8144291", "database": "PubChem Substance", "url": "" }, { "id": "C07639", "database": "COMPOUND", "url": "" }, { "id": "HMDB0060074", "database": "HMDB Metabolite", "url": "" }, { "id": "28774", "database": "ChEBI", "url": "" }, { "id": "2636", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "000004097418", "database": "ZINC", "url": "" }, { "id": "000004097417", "database": "ZINC", "url": "" }, { "id": "8144291", "database": "PubChem Substance", "url": "" }, { "id": "C07639", "database": "COMPOUND", "url": "" }, { "id": "HMDB0060074", "database": "HMDB Metabolite", "url": "" }, { "id": "28774", "database": "ChEBI", "url": "" }, { "id": "2636", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "000004097418", "database": "ZINC", "url": "" }, { "id": "000004097417", "database": "ZINC", "url": "" }, { "id": "8144291", "database": "PubChem Substance", "url": "" }, { "id": "C07639", "database": "COMPOUND", "url": "" }, { "id": "HMDB0060074", "database": "HMDB Metabolite", "url": "" }, { "id": "28774", "database": "ChEBI", "url": "" }, { "id": "2636", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "000004097418", "database": "ZINC", "url": "" }, { "id": "000004097417", "database": "ZINC", "url": "" }, { "id": "8144291", "database": "PubChem Substance", "url": "" }, { "id": "C07639", "database": "COMPOUND", "url": "" }, { "id": "HMDB0060074", "database": "HMDB Metabolite", "url": "" }, { "id": "000004097418", "database": "ZINC", "url": "" }, { "id": "8144291", "database": "PubChem Substance", "url": "" }, { "id": "28774", "database": "ChEBI", "url": "" }, { "id": "HMDB0060074", "database": "HMDB Metabolite", "url": "" }, { "id": "000004097417", "database": "ZINC", "url": "" }, { "id": "2636", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "C07639", "database": "COMPOUND", "url": "" }, { "id": "000004097418", "database": "ZINC", "url": "" }, { "id": "28774", "database": "ChEBI", "url": "" }, { "id": "8144291", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0060074", "database": "HMDB Metabolite", "url": "" }, { "id": "000004097417", "database": "ZINC", "url": "" }, { "id": "2636", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "C07639", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2JZU5", "gene_name": "RGD1559960", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "A0A0G2JZU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JZU5" } ] } ] }, { "uniprot_ac": "A0A8I5ZKG4", "gene_name": "LOC102551938", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "A0A8I5ZKG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZKG4" } ] } ] }, { "uniprot_ac": "O00338", "gene_name": "SULT1C2", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "O00338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00338" } ] }, { "ec_number": "2.8.2.1", "activity": "3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate + H(+).", "evidence": [ { "id": "O00338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00338" } ] }, { "ec_number": "2.8.2.1", "activity": "", "evidence": [ { "id": "O00338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00338" } ] } ] }, { "uniprot_ac": "O43704", "gene_name": "SULT1B1", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "O43704", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43704" } ] }, { "ec_number": "2.8.2.1", "activity": "3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate + H(+).", "evidence": [ { "id": "O43704", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43704" } ] }, { "ec_number": "2.8.2.1", "activity": "", "evidence": [ { "id": "O43704", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43704" } ] } ] }, { "uniprot_ac": "O75897", "gene_name": "SULT1C4", "activity": [ { "ec_number": "2.8.2.1", "activity": "3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate + H(+).", "evidence": [ { "id": "O75897", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75897" } ] }, { "ec_number": "2.8.2.1", "activity": "", "evidence": [ { "id": "O75897", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75897" } ] } ] }, { "uniprot_ac": "P0DMM9", "gene_name": "SULT1A3", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "P0DMM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DMM9" } ] }, { "ec_number": "2.8.2.1", "activity": "3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate + H(+).", "evidence": [ { "id": "P0DMM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DMM9" } ] }, { "ec_number": "2.8.2.1", "activity": "", "evidence": [ { "id": "P0DMM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DMM9" } ] } ] }, { "uniprot_ac": "P0DMN0", "gene_name": "SULT1A4", "activity": [ { "ec_number": "2.8.2.1", "activity": "3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate + H(+).", "evidence": [ { "id": "P0DMN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DMN0" } ] }, { "ec_number": "2.8.2.1", "activity": "", "evidence": [ { "id": "P0DMN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DMN0" } ] } ] }, { "uniprot_ac": "P17988", "gene_name": "Sult1a1", "activity": [ { "ec_number": "2.8.2.1", "activity": "3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate + H(+).", "evidence": [ { "id": "P17988", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17988" } ] }, { "ec_number": "2.8.2.1", "activity": "", "evidence": [ { "id": "P17988", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17988" } ] } ] }, { "uniprot_ac": "P49888", "gene_name": "SULT1E1", "activity": [ { "ec_number": "2.8.2.4", "activity": "3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+).", "evidence": [ { "id": "P49888", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49888" } ] }, { "ec_number": "2.8.2.4", "activity": "", "evidence": [ { "id": "P49888", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49888" } ] } ] }, { "uniprot_ac": "P50225", "gene_name": "SULT1A1", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "P50225", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50225" } ] }, { "ec_number": "2.8.2.1", "activity": "3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate + H(+).", "evidence": [ { "id": "P50225", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50225" } ] }, { "ec_number": "2.8.2.1", "activity": "", "evidence": [ { "id": "P50225", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50225" } ] } ] }, { "uniprot_ac": "P50226", "gene_name": "SULT1A2", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "P50226", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50226" } ] }, { "ec_number": "2.8.2.1", "activity": "3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate + H(+).", "evidence": [ { "id": "P50226", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50226" } ] }, { "ec_number": "2.8.2.1", "activity": "", "evidence": [ { "id": "P50226", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50226" } ] } ] }, { "uniprot_ac": "P52840", "gene_name": "Sult1a1", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "P52840", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52840" } ] }, { "ec_number": "2.8.2.1", "activity": "3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate + H(+).", "evidence": [ { "id": "P52840", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52840" } ] }, { "ec_number": "2.8.2.1", "activity": "", "evidence": [ { "id": "P52840", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52840" } ] } ] }, { "uniprot_ac": "P52847", "gene_name": "Sult1b1", "activity": [ { "ec_number": "2.8.2.1", "activity": "3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate + H(+).", "evidence": [ { "id": "P52847", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52847" } ] }, { "ec_number": "2.8.2.1", "activity": "", "evidence": [ { "id": "P52847", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52847" } ] } ] }, { "uniprot_ac": "Q06520", "gene_name": "SULT2A1", "activity": [ { "ec_number": "2.8.2.14", "activity": "3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate.", "evidence": [ { "id": "Q06520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06520" } ] }, { "ec_number": "2.8.2.2", "activity": "3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+).", "evidence": [ { "id": "Q06520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06520" } ] }, { "ec_number": "2.8.2.2", "activity": "", "evidence": [ { "id": "Q06520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06520" } ] } ] }, { "uniprot_ac": "Q6IMI4", "gene_name": "SULT6B1", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "Q6IMI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6IMI4" } ] }, { "ec_number": "2.8.2.n2", "activity": "3'-phosphoadenylyl sulfate + thyroxine = adenosine 3',5'-bisphosphate + H(+) + thyroxine sulfate.", "evidence": [ { "id": "Q6IMI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6IMI4" } ] } ] }, { "uniprot_ac": "Q6IMI6", "gene_name": "SULT1C3", "activity": [ { "ec_number": "2.8.2.1", "activity": "3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate + H(+).", "evidence": [ { "id": "Q6IMI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6IMI6" } ] }, { "ec_number": "2.8.2.2", "activity": "3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+).", "evidence": [ { "id": "Q6IMI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6IMI6" } ] }, { "ec_number": "2.8.2.2", "activity": "", "evidence": [ { "id": "Q6IMI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6IMI6" } ] }, { "ec_number": "2.8.2.1", "activity": "", "evidence": [ { "id": "Q6IMI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6IMI6" } ] } ] }, { "uniprot_ac": "Q9BR01", "gene_name": "SULT4A1", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "Q9BR01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BR01" } ] } ] }, { "uniprot_ac": "Q9D939", "gene_name": "Sult1c2", "activity": [ { "ec_number": "2.8.2.1", "activity": "3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate + H(+).", "evidence": [ { "id": "Q9D939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D939" } ] }, { "ec_number": "2.8.2.1", "activity": "", "evidence": [ { "id": "Q9D939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D939" } ] } ] }, { "uniprot_ac": "Q9QWG7", "gene_name": "Sult1b1", "activity": [ { "ec_number": "2.8.2.1", "activity": "3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate + H(+).", "evidence": [ { "id": "Q9QWG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QWG7" } ] }, { "ec_number": "2.8.2.1", "activity": "", "evidence": [ { "id": "Q9QWG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QWG7" } ] } ] }, { "uniprot_ac": "Q9WUW8", "gene_name": "Sult1c2", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "Q9WUW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WUW8" } ] }, { "ec_number": "2.8.2.1", "activity": "3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate + H(+).", "evidence": [ { "id": "Q9WUW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WUW8" } ] }, { "ec_number": "2.8.2.1", "activity": "", "evidence": [ { "id": "Q9WUW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WUW8" } ] } ] }, { "uniprot_ac": "Q9WUW9", "gene_name": "Sult1c2a", "activity": [ { "ec_number": "2.8.2.-", "activity": "", "evidence": [ { "id": "Q9WUW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WUW9" } ] }, { "ec_number": "2.8.2.1", "activity": "3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate + H(+).", "evidence": [ { "id": "Q9WUW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WUW9" } ] }, { "ec_number": "2.8.2.1", "activity": "", "evidence": [ { "id": "Q9WUW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WUW9" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 4, 5 ], "snv_sites": [ 4, 241 ], "glycation_sites": [], "phosphorylation_sites": [ 139, 254 ], "sequon_annotation_sites": [ { "start_pos": 240, "end_pos": 242 }, { "start_pos": 28, "end_pos": 30 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 40 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }