{ "uniprot_canonical_ac": "O00321-1", "uniprot_ac": "O00321", "uniprot_id": "ETV2_HUMAN", "mass": { "chemical_mass": 36633.0, "monoisotopic_mass": 36633.0 }, "refseq": { "ac": "NP_055024", "name": "ETS translocation variant 2 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055024" }, "gene_names": [ { "name": "ETV2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O00321", "id": "O00321" }, { "name": "ER71; ETSRP71", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055024", "id": "NP_055024" }, { "name": "ER71", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O00321", "id": "O00321" }, { "name": "ETSRP71", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O00321", "id": "O00321" }, { "name": "ETV2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055024", "id": "NP_055024" } ], "protein_names": [ { "name": "ETS translocation variant 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O00321" }, { "name": "ETS translocation variant 2 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055024", "id": "NP_055024" }, { "name": "Ets-related protein 71", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O00321" }, { "name": "ets variant gene 2; ets-related protein 71", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055024", "id": "NP_055024" } ], "function": [ { "annotation": "A 3-Gene Random Forest Model to Diagnose Non-obstructive Azoospermia Based on Transcription Factor-Related Henes.", "evidence": [ { "database": "RefSeq", "id": "NP_055024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055024" }, { "database": "PubMed", "id": "35715550", "url": "https://glygen.org/publication/PubMed/35715550" } ] }, { "annotation": "Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.", "evidence": [ { "database": "UniProtKB", "id": "O00321", "url": "https://www.uniprot.org/uniprot/O00321#function" } ] }, { "annotation": "ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment.", "evidence": [ { "database": "RefSeq", "id": "NP_055024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055024" }, { "database": "PubMed", "id": "37330911", "url": "https://glygen.org/publication/PubMed/37330911" } ] }, { "annotation": "ETV2 promotes osteogenic differentiation of human dental pulp stem cells through the ERK/MAPK and PI3K-Akt signaling pathways. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_055024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055024" }, { "database": "PubMed", "id": "36195958", "url": "https://glygen.org/publication/PubMed/36195958" } ] }, { "annotation": "ETV2 regulates PARP-1 binding protein to induce ER stress-mediated death in tuberin-deficient cells. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_055024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055024" }, { "database": "PubMed", "id": "35181635", "url": "https://glygen.org/publication/PubMed/35181635" } ] }, { "annotation": "ETV2/ER71, the key factor leading the paths to vascular regeneration and angiogenic reprogramming. 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} ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "62.64", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000105672", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000105672" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "61.55", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000105672", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000105672" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O00321", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O00321" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": 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} ] } }, { "isoform_ac": "O00321-1", "url": "", "sequence": { "sequence": "MDLWNWDEASPQEVPPGNKLAGLEGAKLGFCFPDLALQGDTPTATAETCWKGTSSSLASFPQLDWGSALLHPEVPWGAEPDSQALPWSGDWTDMACTAWDSWSGASQTLGPAPLGPGPIPAAGSEGAAGQNCVPVAGEATSWSRAQAAGSNTSWDCSVGPDGDTYWGSGLGGEPRTDCTISWGGPAGPDCTTSWNPGLHAGGTTSLKRYQSSALTVCSEPSPQSDRASLARCPKTNHRGPIQLWQFLLELLHDGARSSCIRWTGNSREFQLCDPKEVARLWGERKRKPGMNYEKLSRGLRYYYRRDIVRKSGGRKYTYRFGGRVPSLAYPDCAGGGRGAETQ", "length": 342, "header": "sp|O00321-1|ETV2_HUMAN Isoform 1 of ETS translocation variant 2 OS=Homo sapiens OX=9606 GN=ETV2 PE=2 SV=2 CANONICAL=O00321-1" }, "locus": { "chromosome": "19", "start_pos": 35644849, "end_pos": 35642461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000402764.6", "url": "https://www.ensembl.org/id/ENST00000402764.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000384524.2", "url": "https://www.ensembl.org/id/ENSP00000384524.2" } ] } }, { "isoform_ac": "O00321-2", "url": "", "sequence": { "sequence": "MDLWNWDEASPQEVPPGNKLAGLGRLPRLPQRVWGGCPGGASADPNPLSPAEGAKLGFCFPDLALQGDTPTATAETCWKGTSSSLASFPQLDWGSALLHPEVPWGAEPDSQALPWSGDWTDMACTAWDSWSGASQTLGPAPLGPGPIPAAGSEGAAGQNCVPVAGEATSWSRAQAAGSNTSWDCSVGPDGDTYWGSGLGGEPRTDCTISWGGPAGPDCTTSWNPGLHAGGTTSLKRYQSSALTVCSEPSPQSDRASLARCPKTNHRGPIQLWQFLLELLHDGARSSCIRWTGNSREFQLCDPKEVARLWGERKRKPGMNYEKLSRGLRYYYRRDIVRKSGGRKYTYRFGGRVPSLAYPDCAGGGRGAETQ", "length": 370, "header": "sp|O00321-2|ETV2_HUMAN Isoform 2 of ETS translocation variant 2 OS=Homo sapiens OX=9606 GN=ETV2 PE=2 SV=2 CANONICAL=O00321-1" }, "locus": { "chromosome": "19", "start_pos": 35644849, "end_pos": 35642461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000379026.6", "url": "https://www.ensembl.org/id/ENST00000379026.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000368312.2", "url": "https://www.ensembl.org/id/ENSP00000368312.2" } ] } }, { "isoform_ac": "Q3KNT2-1", "url": "", "sequence": { "sequence": "MDLWNWDEASPQEVPPGNKLAGLEGAKLGFCFPDLALQGDTPTATAETCWKGPIQLWQFLLELLHDGARSSCIRWTGNSREFQLCDPKEVARLWGERKRKPGMNYEKLSRGLRYYYRRDIVRKSGGRKYTYRFGGRVPSLAYPDCAGGGRGAETQ", "length": 155, "header": "tr|Q3KNT2-1|Q3KNT2_HUMAN Computationally mapped isoform of ETV2 protein OS=Homo sapiens OX=9606 GN=ETV2 PE=2 SV=1 CANONICAL=O00321-1" }, "locus": { "chromosome": "19", "start_pos": 35644849, "end_pos": 35642461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000379023.8", "url": "https://www.ensembl.org/id/ENST00000379023.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000368309.3", "url": "https://www.ensembl.org/id/ENSP00000368309.3" } ] } }, { "isoform_ac": "S4R454-1", "url": "", "sequence": { "sequence": "QSSALTVCSEPSPQSDRASLARCPKTNHRGPIQLWQFLLELLHDGARSSCIRWTGNSREFQLCDPKEVGQLPCPAKSAPSLLVQFSSAQGLGSTA", "length": 95, "header": "tr|S4R454-1|ETV2_HUMAN Computationally mapped isoform of ETS translocation variant 2 OS=Homo sapiens OX=9606 GN=ETV2 PE=2 SV=1 CANONICAL=O00321-1" }, "locus": { "chromosome": "19", "start_pos": 35644431, "end_pos": 35643666, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000591135.1", "url": "https://www.ensembl.org/id/ENST00000591135.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000475089.1", "url": "https://www.ensembl.org/id/ENSP00000475089.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Interplay among Etsrp/ER71, Scl, and Alk8 signaling controls endothelial and myeloid cell formation.", "journal": "Blood", "date": "2008", "authors": "Sumanas S, Gomez G, Zhao Y, Park C, Choi K, Lin S", "evidence": [ { "database": "RefSeq", "id": "NP_055024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055024" } ], "reference": [ { "type": "PubMed", "id": "18270322", "url": "https://glygen.org/publication/PubMed/18270322" } ] }, { "title": "ETV2 regulates PARP-1 binding protein to induce ER stress-mediated death in tuberin-deficient cells.", "journal": "Life science alliance", "date": "2022", "authors": "Shrestha S, Lamattina A, Pacheco-Rodriguez G, Ng J, Liu X, Sonawane A, Imani J, Qiu W, Kosmas K, Louis P, Hentschel A, Steagall WK, Onishi R, Christou H, Henske EP, Glass K, Perrella MA, Moss J, Tantisira K, El-Chemaly S", "evidence": [ { "database": "RefSeq", "id": "NP_055024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055024" } ], "reference": [ { "type": "PubMed", "id": "35181635", "url": "https://glygen.org/publication/PubMed/35181635" } ] }, { "title": "A 3-Gene Random Forest Model to Diagnose Non-obstructive Azoospermia Based on Transcription Factor-Related Henes.", "journal": "Reproductive sciences (Thousand Oaks, Calif.)", "date": "2022-06-17", "authors": "Zhou Ranran, Liang Jingjing, Chen Qi, Tian Hu, Yang Cheng, Liu Cundong", "evidence": [ { "database": "RefSeq", "id": "NP_055024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055024" } ], "reference": [ { "type": "PubMed", "id": "35715550", "url": "https://glygen.org/publication/PubMed/35715550" } ] }, { "title": "ETV2 promotes osteogenic differentiation of human dental pulp stem cells through the ERK/MAPK and PI3K-Akt signaling pathways.", "journal": "Stem cell research & therapy", "date": "2022-10-04", "authors": "Li Jing, Du Haoran, Ji Xin, Chen Yihan, Li Yishuai, Heng Boon Chin, Xu Jianguang", "evidence": [ { "database": "RefSeq", "id": "NP_055024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055024" } ], "reference": [ { "type": "PubMed", "id": "36195958", "url": "https://glygen.org/publication/PubMed/36195958" } ] }, { "title": "ETV2/ER71, the key factor leading the paths to vascular regeneration and angiogenic reprogramming.", "journal": "Stem cell research & therapy", "date": "2023-03-16", "authors": "Kim Tae Min, Lee Ra Ham, Kim Min Seong, Lewis Chloe A, Park Changwon", "evidence": [ { "database": "RefSeq", "id": "NP_055024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055024" } ], "reference": [ { "type": "PubMed", "id": "36927793", "url": "https://glygen.org/publication/PubMed/36927793" } ] }, { "title": "ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment.", "journal": "Cell reports", "date": "2023-06-17", "authors": "Steimle Jeffrey D, Kim Chul, Rowton Megan, Nadadur Rangarajan D, Wang Zhezhen, Stocker Matthew, Hoffmann Andrew D, Hanson Erika, Kweon Junghun, Sinha Tanvi, Choi Kyunghee, Black Brian L, Cunningham John M, Moskowitz Ivan P, Ikegami Kohta", "evidence": [ { "database": "RefSeq", "id": "NP_055024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055024" } ], "reference": [ { "type": "PubMed", "id": "37330911", "url": "https://glygen.org/publication/PubMed/37330911" } ] } ], "pathway": [ { "id": "hsa:2116", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:2116", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZEY9-1", "protein_name": "ETS variant transcription factor 2", "gene_name": "Etv2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDLWNWDEASVQEVPPGDKLTGLEGAEFGFYFPEVALQGDTPITPMNVESCWKGFPELDWNPALPHEEVPFEAEPVAHPLPWSRDWTDLGCNTSDPWSCASQTPGPAPPGTSPSPFVGFEGATGQNTATSAGGVPSWSHPPATWSTASWDCSAGPNGSTYWDSGLGGEAQADYKMSWGGSAGSDYTTTWNSGLQNCSIPFEGHQIPAFATPSKSSQQSDRATLTPYSKTNHRGPIQLWQFLLELLHDGARSSCIRWTGNNREFQLCDPKEVARLWGERKRKPGMNYEKLSRGLRYYYRRDIVLKSGGRKYTYRFGGRVPVLACQDDMGHLPGAEGQ", "length": 336 }, "evidence": [ { "id": "45933706", "url": "http://www.informatics.jax.org/homology/45933706", "database": "MGI" }, { "id": "O00321", "url": "https://omabrowser.org/oma/group/O00321/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P41163-1", "protein_name": "ETS translocation variant 2", "gene_name": "Etv2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDLWNWDEASLQEVPPGDKLTGLGAEFGFYFPEVALQEDTPITPMNVEGCWKGFPELDWNPALPHEDVPFQAEPVAHPLPWSRDWTDLGCNTSDPWSCASQTPGPAPPGTSPSPFVGFEGATGQNPATSAGGVPSWSHPPAAWSTTSWDCSVGPSGATYWDNGLGGEAHEDYKMSWGGSAGSDYTTTWNTGLQDCSIPFEGHQSPAFTTPSKSNKQSDRATLTRYSKTNHRGPIQLWQFLLELLHDGARSSCIRWTGNSREFQLCDPKEVARLWGERKRKPGMNYEKLSRGLRYYYRRDIVLKSGGRKYTYRFGGRVPVLAYQDDMGHLPGAEGQ", "length": 335 }, "evidence": [ { "id": "45933706", "url": "http://www.informatics.jax.org/homology/45933706", "database": "MGI" }, { "id": "O00321", "url": "https://omabrowser.org/oma/group/O00321/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "O00321", "url": "https://www.uniprot.org/uniprot/O00321" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "O00321", "url": "https://www.uniprot.org/uniprot/O00321" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "O00321", "url": "https://www.uniprot.org/uniprot/O00321" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "O00321", "url": "https://www.uniprot.org/uniprot/O00321" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "O00321", "url": "https://www.uniprot.org/uniprot/O00321" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "O00321", "url": "https://www.uniprot.org/uniprot/O00321" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "O00321", "url": "https://www.uniprot.org/uniprot/O00321" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "O00321", "url": "https://www.uniprot.org/uniprot/O00321" } ], "pmid": "" }, { "name": "Notch signaling pathway", "id": "GO:0007219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007219", "evidence": [ { "database": "UniProtKB", "id": "O00321", "url": "https://www.uniprot.org/uniprot/O00321" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "O00321", "url": "https://www.uniprot.org/uniprot/O00321" } ], "pmid": "" }, { "name": "erythrocyte differentiation", "id": "GO:0030218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030218", "evidence": [ { "database": "UniProtKB", "id": "O00321", "url": "https://www.uniprot.org/uniprot/O00321" } ], "pmid": "" }, { "name": "placenta development", "id": "GO:0001890", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001890", "evidence": [ { "database": "UniProtKB", "id": "O00321", "url": "https://www.uniprot.org/uniprot/O00321" } ], "pmid": "" }, { "name": "blood vessel morphogenesis", "id": "GO:0048514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048514", "evidence": [ { "database": "UniProtKB", "id": "O00321", "url": "https://www.uniprot.org/uniprot/O00321" } ], "pmid": "" }, { "name": "BMP signaling pathway", "id": "GO:0030509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030509", "evidence": [ { "database": "UniProtKB", "id": "O00321", "url": "https://www.uniprot.org/uniprot/O00321" } ], "pmid": "" }, { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "O00321", "url": "https://www.uniprot.org/uniprot/O00321" } ], "pmid": "" }, { "name": "positive regulation of endothelial cell differentiation", "id": "GO:0045603", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045603", "evidence": [ { "database": "UniProtKB", "id": "O00321", "url": "https://www.uniprot.org/uniprot/O00321" } ], "pmid": "" }, { "name": "mesoderm formation", "id": "GO:0001707", "url": 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"isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 151, "end_pos": 153 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { 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