{ "uniprot_canonical_ac": "B3KU38-1", "uniprot_ac": "B3KU38", "uniprot_id": "IQIP1_HUMAN", "mass": { "chemical_mass": 62248.0, "monoisotopic_mass": 62248.0 }, "refseq": { "ac": "NP_001184042", "name": "IQCJ-SCHIP1 readthrough transcript protein isoform 1", "summary": "This locus represents naturally occurring read-through transcription from the neighboring IQ motif containing J (IQCJ) and schwannomin interacting protein 1 (SCHIP1) genes. Alternative splicing results in multiple transcript variants that are composed of in-frame exons from each individual gene. The resulting fusion products are thought to be components of the multimolecular complexes of axon initial segments and nodes of Ranvier, and they may play a role in calcium-mediated responses. [provided by RefSeq, Oct 2010].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184042" }, "gene_names": [ { "name": "IQCJ-SCHIP1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/B3KU38", "id": "B3KU38" }, { "name": "SCHIP1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/B3KU38", "id": "B3KU38" }, { "name": "IQCJ-SCHIP1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184042", "id": "NP_001184042" }, { "name": "SCHIP1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/B3KU38", "id": "B3KU38" }, { "name": "hCG_2022069", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/B3KU38", "id": "B3KU38" } ], "protein_names": [ { "name": "IQCJ-SCHIP1 readthrough transcript protein", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "B3KU38" }, { "name": "IQ motif containing J-schwannomin interacting protein 1 read-through transcript; IQ motif containing J-schwannomin interacting protein 1 fusion protein; IQCJ-SCHIP1 readthrough transcript protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184042", "id": "NP_001184042" }, { "name": "IQCJ-SCHIP1 readthrough transcript protein isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184042", "id": "NP_001184042" } ], "function": [ { "annotation": "May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial segments (PubMed:25950943). May also play a role in axon outgrowth and guidance (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "B3KU38", "url": "https://www.uniprot.org/uniprot/B3KU38#function" }, { "database": "PubMed", "id": "25950943", "url": "https://glygen.org/publication/PubMed/25950943" }, { "database": "UniProtKB", "id": "A0A088MLT8", "url": "https://www.uniprot.org/uniprot/A0A088MLT8#function" } ] }, { "annotation": "This locus represents naturally occurring read-through transcription from the neighboring IQ motif containing J (IQCJ) and schwannomin interacting protein 1 (SCHIP1) genes. Alternative splicing results in multiple transcript variants that are composed of in-frame exons from each individual gene. The resulting fusion products are thought to be components of the multimolecular complexes of axon initial segments and nodes of Ranvier, and they may play a role in calcium-mediated responses. [provided by RefSeq, Oct 2010].", "evidence": [ { "database": "RefSeq", "id": "NP_001184042", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184042" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "86.72", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000283154", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000283154" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "82.67", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000283154", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000283154" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "95.19", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000283154", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000283154" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "80.2", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000283154", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000283154" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "91.26", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000283154", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000283154" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "77.49", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000283154", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000283154" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "73.81", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000283154", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000283154" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "85.98", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000283154", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000283154" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "87.66", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000283154", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000283154" } ] } ], "expression_disease": [], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "B3KU38", "url": "https://www.uniprot.org/uniprot/B3KU38" } ], "common_name": "Human" } ], "gene": [ { "name": "IQCJ-SCHIP1", "url": "https://www.uniprot.org/uniprot/B3KU38", "locus": { "chromosome": "3", "start_pos": 159897629, "end_pos": 158962235, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000283154", "url": "https://www.ensembl.org/id/ENSG00000283154" } ] } } ], "crossref": [ { "id": "ENSG00000151967", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000151967", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSG00000283154", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000283154", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IQCJ-SCHIP1", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=IQCJ-SCHIP1", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "100505385", "url": "https://www.ncbi.nlm.nih.gov/gene/100505385", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "15678", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=15678", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "38842", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=38842", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "IPR015649", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015649", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029362", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029362", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039045", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039045", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:100505385", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:100505385", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NX_B3KU38", "url": "https://www.nextprot.org/entry/NX_B3KU38", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "MTHENSS", "url": "https://omabrowser.org/oma/group/MTHENSS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PDPKCSL", "url": "https://omabrowser.org/oma/group/PDPKCSL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2908254at2759", "url": "http://www.orthodb.org/?query=2908254at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13103", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13103", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13103:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13103:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13103:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13103:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35976", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35976", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35976:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35976:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10148", "url": "http://pfam.xfam.org/family/PF10148", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF15157", "url": "http://pfam.xfam.org/family/PF15157", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "B3KU38", "url": "https://pharos.nih.gov/targets/B3KU38", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_B3KU38", "url": "http://purl.obolibrary.org/obo/PR_B3KU38", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001184042", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184042", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A1W2PP08", "url": "https://www.uniprot.org/uniprot/A0A1W2PP08", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PP08-1", "url": "https://www.uniprot.org/uniprot/A0A1W2PP08-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PPY3", "url": "https://www.uniprot.org/uniprot/A0A1W2PPY3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PPY3-1", "url": "https://www.uniprot.org/uniprot/A0A1W2PPY3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PQT1", "url": "https://www.uniprot.org/uniprot/A0A1W2PQT1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PQT1-1", "url": "https://www.uniprot.org/uniprot/A0A1W2PQT1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PR78", "url": "https://www.uniprot.org/uniprot/A0A1W2PR78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PR78-1", "url": "https://www.uniprot.org/uniprot/A0A1W2PR78-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PR91", "url": "https://www.uniprot.org/uniprot/A0A1W2PR91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PR91-1", "url": "https://www.uniprot.org/uniprot/A0A1W2PR91-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PRV6", "url": "https://www.uniprot.org/uniprot/A0A1W2PRV6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PRV6-1", "url": "https://www.uniprot.org/uniprot/A0A1W2PRV6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PRY4", "url": "https://www.uniprot.org/uniprot/A0A1W2PRY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2PRY4-1", "url": "https://www.uniprot.org/uniprot/A0A1W2PRY4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5KTZ3", "url": "https://www.uniprot.org/uniprot/A0A8I5KTZ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5KTZ3-1", "url": "https://www.uniprot.org/uniprot/A0A8I5KTZ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B3KU38", "url": "https://www.uniprot.org/uniprot/B3KU38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B3KU38-1", "url": "https://www.uniprot.org/uniprot/B3KU38-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B3KU38-2", "url": "https://www.uniprot.org/uniprot/B3KU38-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9J366", "url": "https://www.uniprot.org/uniprot/C9J366", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9J366-1", "url": "https://www.uniprot.org/uniprot/C9J366-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9JWG6", "url": "https://www.uniprot.org/uniprot/C9JWG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9JWG6-1", "url": "https://www.uniprot.org/uniprot/C9JWG6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F8WDG0", "url": "https://www.uniprot.org/uniprot/F8WDG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F8WDG0-1", "url": "https://www.uniprot.org/uniprot/F8WDG0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLEELKRLQNPLEQVNDGKYSFENHQLAMDAENNIEKYPLNLQPLESKVKIIQRAWREYLQRQEPLGKRSPSPPSVSSEKLSSSVSMNTFSDSSTPDYREDGMDLGSDAGSSSSSSRASSQSNSTKVTPCSECKSSSSPGGSLDLVSALEDYEEPFPVYQKKVIDEWAPEEDGEEEEEEDERDQRGYRDDRSPAREPGDVSARTRSGGGGGRSATTAMPPPVPNGNLHQHDPQDLRHNGNVVVAGRPSCSRGPRRAIQKPQPAGGRRSGRGPAAGGLCLQPPDGGTCVPEEPPVPPMDWEALEKHLAGLQFREQEVRNQGQARTNSTSAQKNERESIRQKLALGSFFDDGPGIYTSCSKSGKPSLSSRLQSGMNLQICFVNDSGSDKDSDADDSKTETSLDTPLSPMSKQSSSYSDRDTTEEESESLDDMDFLTRQKKLQAEAKMALAMAKPMAKMQVEVEKQNRKKSPVADLLPHMPHISECLMKRSLKPTDLRDMTIGQLQVIVNDLHSQIESLNEELVQLLLIRDELHTEQDAMLVDIEDLTRHAESQQKHMAEKMPAK", "length": 563, "header": "sp|B3KU38-1|IQIP1_HUMAN Isoform 1 of IQCJ-SCHIP1 readthrough transcript protein OS=Homo sapiens OX=9606 GN=IQCJ-SCHIP1 PE=1 SV=2 CANONICAL=B3KU38-1" }, "isoforms": [ { "isoform_ac": "A0A1W2PP08-1", "url": "", "sequence": { "sequence": "MQMEELKRLQNPLEQVNDGKYSFENHQLAMDAENNIEKYPLNLQPLESKVKIIQRAWREYLQRQEPLGKRSPSPPSVSSEKLSSSVSMNTFSDSSTPDYREDGMDLGSDAGSSSSSSRASSQSNSTKVTPCSECKSSSSPGGSLDLVSALEDY", "length": 153, "header": "tr|A0A1W2PP08-1|IQIP1_HUMAN Computationally mapped isoform of IQCJ-SCHIP1 readthrough transcript protein OS=Homo sapiens OX=9606 GN=IQCJ-SCHIP1 PE=1 SV=1 CANONICAL=B3KU38-1" }, "locus": { "chromosome": "3", "start_pos": 159764610, "end_pos": 159069797, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000639631.1", "url": "https://www.ensembl.org/id/ENST00000639631.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000491220.1", "url": "https://www.ensembl.org/id/ENSP00000491220.1" } ] } }, { "isoform_ac": "A0A1W2PPY3-1", "url": "", "sequence": { "sequence": "MQMEELKRLQNPLEQVNDGKYSFENIQRAWREYLQRQEPLGKRSPSPPSVSSEKLSSSVSMNTFSDSSTPDYREDGMDLGSDAGSSSSSSRASSQSNSTKVTPCSECKSSSSPGGSLDLVSALEDYEEPFPVYQKKVIDEWAPEEDGEEEEEEDERDQ", "length": 158, "header": "tr|A0A1W2PPY3-1|IQIP1_HUMAN Computationally mapped isoform of IQCJ-SCHIP1 readthrough transcript protein OS=Homo sapiens OX=9606 GN=IQCJ-SCHIP1 PE=1 SV=1 CANONICAL=B3KU38-1" }, "locus": { "chromosome": "3", "start_pos": 159764706, "end_pos": 159069797, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000639298.1", "url": "https://www.ensembl.org/id/ENST00000639298.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000491419.1", "url": "https://www.ensembl.org/id/ENSP00000491419.1" } ] } }, { "isoform_ac": "A0A1W2PQT1-1", "url": "", "sequence": { "sequence": "MDLGSDAGSSSSSSRASSQSNSTKVTPCSECKSSSSPGGSLDLVSALEDYEEPFPVYQKKVIDEWAPEEDGEEEEEEDERDQRGYRDDRSPAREPGDVSARTRSGGGGGRSATTAMPPPVPNGNLHQHDPQDLRHNGNVVVAGRPSCSRGPRRAIQKPQPAGGRRSG", "length": 167, "header": "tr|A0A1W2PQT1-1|A0A1W2PQT1_HUMAN Computationally mapped isoform of IQCJ-SCHIP1 readthrough OS=Homo sapiens OX=9606 GN=IQCJ-SCHIP1 PE=1 SV=1 CANONICAL=B3KU38-1" }, "locus": { "chromosome": "3", "start_pos": 159764961, "end_pos": 159764461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000640565.1", "url": "https://www.ensembl.org/id/ENST00000640565.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000492132.1", "url": "https://www.ensembl.org/id/ENSP00000492132.1" } ] } }, { "isoform_ac": "A0A1W2PR78-1", "url": "", "sequence": { "sequence": "XGTRARRGPTPPPHRKMRESLSDRSWHLEASLMMAQEFIPAVAKVGSQAFPPGLNEELVQLLLIRDELHTEQDAMLVDIEDLTRHAESQQKHMAEKMPAK", "length": 100, "header": "tr|A0A1W2PR78-1|A0A1W2PR78_HUMAN Computationally mapped isoform of IQCJ-SCHIP1 readthrough OS=Homo sapiens OX=9606 GN=IQCJ-SCHIP1 PE=4 SV=1 CANONICAL=B3KU38-1" }, "locus": { "chromosome": "3", "start_pos": 159896773, "end_pos": 159765103, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000638311.1", "url": "https://www.ensembl.org/id/ENST00000638311.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000492358.1", "url": "https://www.ensembl.org/id/ENSP00000492358.1" } ] } }, { "isoform_ac": "A0A1W2PR91-1", "url": "", "sequence": { "sequence": "MDLGSDAGSSSSSSRASSQSNSTKVTPCSECKSSSSPGGSLDLVSALEDYEEPFPVYQKKVIDEWAPEEDGEEEEEEDERDQRGYRDDRSPAREPGDVSARTRSGGGGGRSATTAMPPPVPNGNLHQHDPQDLRHNGNVVVAG", "length": 143, "header": "tr|A0A1W2PR91-1|A0A1W2PR91_HUMAN Computationally mapped isoform of IQCJ-SCHIP1 readthrough OS=Homo sapiens OX=9606 GN=IQCJ-SCHIP1 PE=1 SV=1 CANONICAL=B3KU38-1" }, "locus": { "chromosome": "3", "start_pos": 159764889, "end_pos": 159764461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000639448.1", "url": "https://www.ensembl.org/id/ENST00000639448.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000492497.1", "url": "https://www.ensembl.org/id/ENSP00000492497.1" } ] } }, { "isoform_ac": "A0A1W2PRV6-1", "url": "", "sequence": { "sequence": "MDAENNIEKYPLNLQPLESKVKIIQRAWREYLQRQEPLGKRSPSPPSVSSEKLSSSVSMNTFSDSSTPDYREDGMDLGSDAGSSSSSSRAS", "length": 91, "header": "tr|A0A1W2PRV6-1|A0A1W2PRV6_HUMAN Computationally mapped isoform of IQCJ-SCHIP1 readthrough OS=Homo sapiens OX=9606 GN=IQCJ-SCHIP1 PE=1 SV=1 CANONICAL=B3KU38-1" }, "locus": { "chromosome": "3", "start_pos": 159764511, "end_pos": 159252740, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000639979.1", "url": "https://www.ensembl.org/id/ENST00000639979.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000492461.1", "url": "https://www.ensembl.org/id/ENSP00000492461.1" } ] } }, { "isoform_ac": "A0A1W2PRY4-1", "url": "", "sequence": { "sequence": "MRLEELKRLQNPLEQVNDGKYSFENHQLAMDAENNIEKYPLNLQPLESKHSASMARVPAAAGAPGEEEPVPTLCLLREAEQLCQHEHLLRQQHTRLPRGWD", "length": 101, "header": "tr|A0A1W2PRY4-1|IQIP1_HUMAN Computationally mapped isoform of IQCJ-SCHIP1 readthrough transcript protein OS=Homo sapiens OX=9606 GN=IQCJ-SCHIP1 PE=1 SV=1 CANONICAL=B3KU38-1" }, "locus": { "chromosome": "3", "start_pos": 159764462, "end_pos": 159069433, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000640015.1", "url": "https://www.ensembl.org/id/ENST00000640015.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000492853.1", "url": "https://www.ensembl.org/id/ENSP00000492853.1" } ] } }, { "isoform_ac": "A0A8I5KTZ3-1", "url": "", "sequence": { "sequence": "MDLGSDAGSSSSSSRASSQSNSTKVTPCSECKSSSSPGGSLDLVSALEDYEEPFPVYQKKVIDEWAPEEDGEEEEEEDERDQRGYRDDRSPAREPGDVSARTRSGGGGGRSATTAMPPPVPNGNLHQHDPQDLRHNGNVVVAGRPSCSRGPRRAIQKPQPAGGRRSGRGPAAGGLCLQPPDGGTCVPEEPPVPPMDWEALEKHLAGLQFREQEVRNQGQARTNSTSAQKNERESIRQKLALGSFFDDGPGIYTSCSKSGKPSLSSRLQSGMNLQICFVNDSGSDKDSDADDSKTETSLDTPLSPMSKQSSSYSDRDTTEEESESLDDMDFLTRQKKLQAEAKMALAMAKPMAKMQVEVEKQNRKKSPVADLLPHMPHISECLMKRSLKPTDLRDMTIGQLQVIVNDLHSQIESLNEELVQLLLIRDELHTEQDAMLVDIEDLTRHAESQQKHMAEKMPAK", "length": 460, "header": "tr|A0A8I5KTZ3-1|A0A8I5KTZ3_HUMAN Computationally mapped isoform of IQCJ-SCHIP1 readthrough OS=Homo sapiens OX=9606 GN=IQCJ-SCHIP1 PE=1 SV=1 CANONICAL=B3KU38-1" }, "locus": { "chromosome": "3", "start_pos": 159896771, "end_pos": 159764461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000689690.1", "url": "https://www.ensembl.org/id/ENST00000689690.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000508586.1", "url": "https://www.ensembl.org/id/ENSP00000508586.1" } ] } }, { "isoform_ac": "B3KU38-1", "url": "", "sequence": { "sequence": "MRLEELKRLQNPLEQVNDGKYSFENHQLAMDAENNIEKYPLNLQPLESKVKIIQRAWREYLQRQEPLGKRSPSPPSVSSEKLSSSVSMNTFSDSSTPDYREDGMDLGSDAGSSSSSSRASSQSNSTKVTPCSECKSSSSPGGSLDLVSALEDYEEPFPVYQKKVIDEWAPEEDGEEEEEEDERDQRGYRDDRSPAREPGDVSARTRSGGGGGRSATTAMPPPVPNGNLHQHDPQDLRHNGNVVVAGRPSCSRGPRRAIQKPQPAGGRRSGRGPAAGGLCLQPPDGGTCVPEEPPVPPMDWEALEKHLAGLQFREQEVRNQGQARTNSTSAQKNERESIRQKLALGSFFDDGPGIYTSCSKSGKPSLSSRLQSGMNLQICFVNDSGSDKDSDADDSKTETSLDTPLSPMSKQSSSYSDRDTTEEESESLDDMDFLTRQKKLQAEAKMALAMAKPMAKMQVEVEKQNRKKSPVADLLPHMPHISECLMKRSLKPTDLRDMTIGQLQVIVNDLHSQIESLNEELVQLLLIRDELHTEQDAMLVDIEDLTRHAESQQKHMAEKMPAK", "length": 563, "header": "sp|B3KU38-1|IQIP1_HUMAN Isoform 1 of IQCJ-SCHIP1 readthrough transcript protein OS=Homo sapiens OX=9606 GN=IQCJ-SCHIP1 PE=1 SV=2 CANONICAL=B3KU38-1" }, "locus": { "chromosome": "3", "start_pos": 159896771, "end_pos": 159069433, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000485419.7", "url": "https://www.ensembl.org/id/ENST00000485419.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000420182.1", "url": "https://www.ensembl.org/id/ENSP00000420182.1" } ] } }, { "isoform_ac": "B3KU38-2", "url": "", "sequence": { "sequence": "MRLEELKRLQNPLEQVNDGKYSFENIQRAWREYLQRQEPLGKRSPSPPSVSSEKLSSSVSMNTFSDSSTPDYREDGMDLGSDAGSSSSSSRASSQSNSTKVTPCSECKSSSSPGGSLDLVSALEDYEEPFPVYQKKVIDEWAPEEDGEEEEEEDERDQRGYRDDRSPAREPGDVSARTRSGGGGGRSATTAMPPPVPNGNLHQHDPQDLRHNGNVVVAGRPSCSRGPRRAIQKPQPAGGRRSGRGPAAGGLCLQPPDGGTCVPEEPPVPPMDWEALEKHLAGLQFREQEVRNQGQARTNSTSAQKNERESIRQKLALGSFFDDGPGIYTSCSKSGKPSLSSRLQSGMNLQICFVNDSGSDKDSDADDSKTETSLDTPLSPMSKQSSSYSDRDTTEEESESLDDMDFLTRQKKLQAEAKMALAMAKPMAKMQVEVEKQNRKKSPVADLLPHMPHISECLMKRSLKPTDLRDMTIGQLQVIVNDLHSQIESLNEELVQLLLIRDELHTEQDAMLVDIEDLTRHAESQQKHMAEKMPAK", "length": 536, "header": "sp|B3KU38-2|IQIP1_HUMAN Isoform 2 of IQCJ-SCHIP1 readthrough transcript protein OS=Homo sapiens OX=9606 GN=IQCJ-SCHIP1 PE=1 SV=2 CANONICAL=B3KU38-1" }, "locus": { "chromosome": "3", "start_pos": 159896771, "end_pos": 159069433, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000476809.7", "url": "https://www.ensembl.org/id/ENST00000476809.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000418692.1", "url": "https://www.ensembl.org/id/ENSP00000418692.1" } ] } }, { "isoform_ac": "C9J366-1", "url": "", "sequence": { "sequence": "MDLGSDAGSSSSSSRASSQSNSTKVTPCSECKSSSSPGGSLDLVSALEDYEEPFPVYQKKVIDEWAPEEDGEEEEEEDERDQRGYRDDRSPAREPGDVSARTRSGGGGGRSATTAMPPPVPNGNLHQHDPQDLRHNGNVVVAGRPSCSRGPRRAIQKPQPAGGRRSGRGPAAGGLCLQPPDGGTCVPEEPPVPPMDWEALEKHLAGLQFREQEAQKNERESIRQKLALGSFFDDGPGIYTSCSKSGKPSLSSRLQSGMNLQICFVNDSGSDKDSDADDSKTETSLDTPLSPMSKQSSSYSDRDTTEEESESLDDMDFLTRQKKLQAEAKMALAMAKPMAKMQVEVEKQNRKKSPVADLLPHMPHISECLMKRSLKPTDLRDMTIGQLQVIVNDLHSQIESLNEELVQLLLIRDELHTEQDAMLVDIEDLTRSVWLHSCQRRKAQGGLKSKN", "length": 451, "header": "tr|C9J366-1|C9J366_HUMAN Computationally mapped isoform of IQCJ-SCHIP1 readthrough OS=Homo sapiens OX=9606 GN=IQCJ-SCHIP1 PE=1 SV=3 CANONICAL=B3KU38-1" }, "locus": { "chromosome": "3", "start_pos": 159892251, "end_pos": 159764461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000460298.3", "url": "https://www.ensembl.org/id/ENST00000460298.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000417305.3", "url": "https://www.ensembl.org/id/ENSP00000417305.3" } ] } }, { "isoform_ac": "C9JWG6-1", "url": "", "sequence": { "sequence": "MNLDSDGMDDIISQESSLDMEGNYKKAQKNERESIRQKLALGSFFDDGPGIYTSCSKSGKPSLSSRLQSGMNLQICFVNDSGSDKDSDADDSKTETSLDTPLSPMSKQSSSYSDRDTTEEESESLDDMDFLTRQKKLQAEAKMALAMAKPMAKMQVEVEKQNRKKSPVADLLPHMPHISECLMKRSLKPTDLRDMTIGQLQVIVNDLHSQIESLNEELVQLLLIRDELHTEQDAMLVDIEDLTRHAESQQKHMAEKMPAK", "length": 260, "header": "tr|C9JWG6-1|C9JWG6_HUMAN Computationally mapped isoform of Schwannomin interacting protein 1 OS=Homo sapiens OX=9606 GN=SCHIP1 PE=4 SV=1 CANONICAL=B3KU38-1" }, "locus": { "chromosome": "3", "start_pos": 159896771, "end_pos": 159853380, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000482804.1", "url": "https://www.ensembl.org/id/ENST00000482804.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000419230.1", "url": "https://www.ensembl.org/id/ENSP00000419230.1" } ] } }, { "isoform_ac": "F8WDG0-1", "url": "", "sequence": { "sequence": "MVHQDNCSYQAQKNERESIRQKLALGSFFDDGPGIYTSCSKSGKPSLSSRLE", "length": 52, "header": "tr|F8WDG0-1|IQIP1_HUMAN Computationally mapped isoform of IQCJ-SCHIP1 readthrough transcript protein OS=Homo sapiens OX=9606 GN=IQCJ-SCHIP1 PE=1 SV=1 CANONICAL=B3KU38-1" }, "locus": { "chromosome": "3", "start_pos": 159892103, "end_pos": 159840185, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000495954.5", "url": "https://www.ensembl.org/id/ENST00000495954.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000420376.1", "url": "https://www.ensembl.org/id/ENSP00000420376.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 193, "end_pos": 193, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "B3KU38", "url": "https://www.uniprot.org/uniprot/B3KU38" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "B3KU38", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/B3KU38" } ], "site_lbl": "Ser193" } ], "glycation": [], "keywords": [], "publication": [ { "title": "IQCJ-SCHIP1, a novel fusion transcript encoding a calmodulin-binding IQ motif protein.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2006", "authors": "Kwasnicka-Crawford DA, Carson AR, Scherer SW", "evidence": [ { "database": "UniProtKB", "id": "B3KU38", "url": "https://www.uniprot.org/uniprot/B3KU38" } ], "reference": [ { "type": "PubMed", "id": "17045569", "url": "https://glygen.org/publication/PubMed/17045569" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "B3KU38", "url": "https://www.uniprot.org/uniprot/B3KU38" }, { "database": "iPTMnet", "id": "B3KU38", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/B3KU38" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment.", "journal": "Journal of neurochemistry", "date": "2015", "authors": "Papandreou MJ, Vacher H, Fache MP, Klingler E, Rueda-Boroni F, Ferracci G, Debarnot C, Piperoglou C, Garcia Del Cano G, Goutebroze L, Dargent B", "evidence": [ { "database": "UniProtKB", "id": "B3KU38", "url": "https://www.uniprot.org/uniprot/B3KU38" } ], "reference": [ { "type": "PubMed", "id": "25950943", "url": "https://glygen.org/publication/PubMed/25950943" } ] } ], "pathway": [ { "id": "hsa:100505385", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:100505385", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A088MLT8-1", "protein_name": "IQCJ-SCHIP1 readthrough transcript protein", "gene_name": "Iqcj-Schip1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRLEELKRLQNPLEQVDDGKYLLENHQLAMDVENNIENYPLSLQPLESKVKIIQRAWREYLQRQDPLEKRSPSPPSVSSDKLSSSVSMNTFSDSSTPDYREDGMDLGSDAGSSSSSRASSQSNSTKVTPCSECKSSSSPGGSLDLVSALEDYEEPFPVYQKKVIDEWAPEEDGEEEEEEDDRGYRDDGCPAREPGDVSARIGSSGSGSRSAATTMPSPMPNGNLHPHDPQDLRHNGNVVVAGRPNASRVPRRPIQKTQPPGSRRGGRNRASGGLCLQPPDGGTRVPEEPPAPPMDWEALEKHLAGLQFREQEVRNQGQARTNSTSAQKNERESIRQKLALGSFFDDGPGIYTSCSKSGKPSLSARLQSGMNLQICFVNDSGSDKDSDADDSKTETSLDTPLSPMSKQSSSYSDRDTTEEESESLDDMDFLTRQKKLQAEAKMALAMAKPMAKMQVEVEKQNRKKSPVADLLPHMPHISECLMKRSLKPTDLRDMTIGQLQVIVNDLHSQIESLNEELVQLLLIRDELHTEQDAMLVDIEDLTRHAESQQKHMAEKMPAK", "length": 559 }, "evidence": [ { "id": "45926167", "url": "http://www.informatics.jax.org/homology/45926167", "database": "MGI" }, { "id": "B3KU38", "url": "https://omabrowser.org/oma/group/B3KU38/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A8I6AUB8-1", "protein_name": "Schwannomin interacting protein 1", "gene_name": "Schip1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MERSEQRLRAAWDCDPGKQADRDYREDGMDLGSDAGSSSSSSRASSQSNSTKVTPCSECKSSSSPGGSLDLVSALEDYEEPFPVYQKKVIDEWAPEEDGEEEEEEDDRGYRDDRCPAREPGDVSARIGGSGSGNRSAATTMPSPMPNGNLHPHDPQDLRHNGNLVIAGRPNASRVPRRPIQKTQPPGNRRGGRNRASGGLCLQPPDGGMRVPEEPPAPPMDWEALEKHLAGLQFREQEVRNQGQARTNSTSAQKNERESIRQKLALGSFFDDGPGIYTSCSKSGKPSLSSRLQSGMNLQICFVNDSGSDKDSDADDSKTETSLDTPLSPMSKQSSSYSDRDTTEEESESLDDMDFLTRQKKLQAEAKMALAMAKPMAKMQVEVEKQNRKKSPVADLLPHMPHISECLMKRSLKPTDLRDMTIGQLQVIVNDLHSQIESLNEELVQLLLIRDELHTEQDAMLVDIEDLTRHAESQQKHMAEKMPSK", "length": 485 }, "evidence": [ { "id": "45926167", "url": "http://www.informatics.jax.org/homology/45926167", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of cytoskeleton organization", "id": "GO:0051494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051494", "evidence": [ { "database": "UniProtKB", "id": "B3KU38", "url": "https://www.uniprot.org/uniprot/B3KU38" } ], "pmid": "" }, { "name": "positive regulation of hippo signaling", "id": "GO:0035332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035332", "evidence": [ { "database": "UniProtKB", "id": "B3KU38", "url": "https://www.uniprot.org/uniprot/B3KU38" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "B3KU38", "url": "https://www.uniprot.org/uniprot/B3KU38" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "B3KU38", "url": "https://www.uniprot.org/uniprot/B3KU38" } ], "pmid": "" }, { "name": "cell junction", "id": "GO:0030054", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030054", "evidence": [ { "database": "UniProtKB", "id": "B3KU38", "url": "https://www.uniprot.org/uniprot/B3KU38" } ], "pmid": "" }, { "name": "axon initial segment", "id": "GO:0043194", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043194", "evidence": [ { "database": "UniProtKB", "id": "B3KU38", "url": "https://www.uniprot.org/uniprot/B3KU38" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "B3KU38", "url": "https://www.uniprot.org/uniprot/B3KU38" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "B3KU38", "url": "https://www.uniprot.org/uniprot/B3KU38" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "B3KU38", "url": "https://www.uniprot.org/uniprot/B3KU38" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 124, "end_pos": 126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 326, "end_pos": 328, "annotation": "n_glycosylation_sequon" }, { "start_pos": 382, "end_pos": 384, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 193 ], "sequon_annotation_sites": [ { "start_pos": 124, "end_pos": 126 }, { "start_pos": 326, "end_pos": 328 }, { "start_pos": 382, "end_pos": 384 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }