{
    "uniprot_canonical_ac": "B0M0P5-1",
    "uniprot_ac": "B0M0P5",
    "uniprot_id": "DDB1_DICDI",
    "mass": {
        "chemical_mass": 132254.0,
        "monoisotopic_mass": 132254.0
    },
    "refseq": {
        "ac": "XP_637896",
        "name": "UV-damaged DNA binding protein1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/XP_637896"
    },
    "gene_names": [
        {
            "name": "repE",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/B0M0P5",
            "id": "B0M0P5"
        },
        {
            "name": "DDB_G0286013",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/B0M0P5",
            "id": "B0M0P5"
        },
        {
            "name": "ddb1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/B0M0P5",
            "id": "B0M0P5"
        },
        {
            "name": "repE",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_637896",
            "id": "XP_637896"
        }
    ],
    "protein_names": [
        {
            "name": "DNA damage-binding protein 1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "B0M0P5"
        },
        {
            "name": "DNA repair protein E",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "B0M0P5"
        },
        {
            "name": "UV-damaged DNA binding protein1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_637896",
            "id": "XP_637896"
        },
        {
            "name": "UV-damaged DNA-binding protein 1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "B0M0P5"
        }
    ],
    "function": [
        {
            "annotation": "Plays a role in DNA repair. May be a component of an E3 ubiquitin-protein ligase which promotes histone ubiquitination in response to UV irradiation. Histone ubiquitination may be important for subsequent DNA repair (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "B0M0P5",
                    "url": "https://www.uniprot.org/uniprot/B0M0P5#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Dictyostelium discoideum",
            "taxid": 44689,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "B0M0P5",
                    "url": "https://www.uniprot.org/uniprot/B0M0P5"
                }
            ],
            "common_name": "Cellular slime molds"
        }
    ],
    "gene": [
        {
            "name": "repE",
            "url": "https://www.uniprot.org/uniprot/B0M0P5",
            "locus": {}
        }
    ],
    "crossref": [
        {
            "id": "DDB_G0286013",
            "url": "http://dictybase.org/gene/DDB_G0286013",
            "database": "dictyBase",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "8625406",
            "url": "https://www.ncbi.nlm.nih.gov/gene/8625406",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR004871",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR004871",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011047",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011047",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR015943",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR018846",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018846",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036322",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "ddi:DDB_G0286013",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0286013",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "HQDFLMR",
            "url": "https://omabrowser.org/oma/group/HQDFLMR/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10644",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10644",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10644:SF3",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10644:SF3",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF03178",
            "url": "http://pfam.xfam.org/family/PF03178",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF10433",
            "url": "http://pfam.xfam.org/family/PF10433",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_B0M0P5",
            "url": "http://purl.obolibrary.org/obo/PR_B0M0P5",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-DDI-110314",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-110314",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DDI-5696394",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-5696394",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DDI-5696395",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-5696395",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DDI-6781823",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6781823",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DDI-6782135",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6782135",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DDI-6782210",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6782210",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DDI-8951664",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8951664",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "XP_637896",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_637896",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "B0M0P5",
            "url": "https://www.uniprot.org/uniprot/B0M0P5",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "B0M0P5-1",
            "url": "https://www.uniprot.org/uniprot/B0M0P5-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MYNFVSTVQKPTSVTHSVTGNFTGPNDKNLIISKCTKIEIFLMDQDGLKPMFDVNIYGRISVLKLFSVAGSKQDYLFISTESFKFCILAYDYEKKEIITKASGNAEDTIGRPTEAGQLGIIDPDGRIVALHLYEGLLKLITLDNNNTPNKINNNNNNNNNNNNNNNNNNNNNINNNNFNINNNNNNSPIQKNVNNVRLEELQVLDMTFLYGCKVPTIAVLFKDTKDEKHISTYEISSKDTELVVGPWSQSNVGVYSSLLVPVPLGGVLVVADNGITYLNGKVTRSVAVSYTKFLAFTRVDKDGSRFLFGDHFGRLSVLVLIHQQQKVMELKFEQLGRISIPSSISYLDSGVVYIGSSSGDSQLIRLNTEKDQTTDSYVTYLEAFTNIGPVVDFCVVDAEKQGQAQIVTCSGTYRDGSLRIIRNGIGIAEQASIELEGIKGIFPINNNNNNNNNNNNNNNNNNNNNSNGITDSKDRYLITSFIECTKVLSFQGEEIEETEFEGLESNCSTLYCGTIDKLNLLIQITNVSINLIDSNTFKRVSQWNVEPSRRINLVSTNQDQIVLSIDKSLLYFQINSSNKSIQLVKEIELPHEISCIDISPFDSFMDTKSQLVSVGLWNDITLRIFKLPTLEEIWKEPLGGEILPRSILMISFDSIDYIFCSLGDGHLFKFQFDFSSFKLFDKRKLTLGTQPIILKKFKLKNTINIFAISDRPTVIYSHNKKLFYSVVNLKDVTNVTSFNSDGFPNSMAIATTNSLTIGTIDEIQKLHIKTIPLNEEMGRRIVHLEDHSCYAVITVKNNEGLLGGAQDLCEEDEEVSYIRIYNDQTFELISSYKLDPYEMGWSITPCKFAGDDVNTYLAVGTSINTPIKSSGRVLLFSLSSSSSSNDKDSLDNNNNNNNNSGANGKLTLLEEIKFRSSVYFLLSFNGRLIAAVHKRLFSIRYTHSKEKNCKVISSESVHKGHTMILKLASRGHFILVGDMMKSMSLLVEQSDGSLEQIARNPQPIWIRSVAMINDDYFIGAEASNNFIVVKKNNDSTNELERELLDSVGHYHIGESINSMRHGSLVRLPDSDQPIIPTILYASVNGSIGVVASISEEDFIFFSKLQKGLNQVVRGVGGFSHETWRAFSNDHHTIDSKNFIDGDLIETFLDLKYESQLKAVADLGITPDDAFRRIESLMQYIR",
        "length": 1181,
        "header": "sp|B0M0P5-1|DDB1_DICDI Isoform 1 of DNA damage-binding protein 1  OS=Dictyostelium discoideum OX=44689 GN=repE PE=1 SV=1 CANONICAL=B0M0P5-1"
    },
    "isoforms": [
        {
            "isoform_ac": "B0M0P5-1",
            "url": "",
            "sequence": {
                "sequence": "MYNFVSTVQKPTSVTHSVTGNFTGPNDKNLIISKCTKIEIFLMDQDGLKPMFDVNIYGRISVLKLFSVAGSKQDYLFISTESFKFCILAYDYEKKEIITKASGNAEDTIGRPTEAGQLGIIDPDGRIVALHLYEGLLKLITLDNNNTPNKINNNNNNNNNNNNNNNNNNNNNINNNNFNINNNNNNSPIQKNVNNVRLEELQVLDMTFLYGCKVPTIAVLFKDTKDEKHISTYEISSKDTELVVGPWSQSNVGVYSSLLVPVPLGGVLVVADNGITYLNGKVTRSVAVSYTKFLAFTRVDKDGSRFLFGDHFGRLSVLVLIHQQQKVMELKFEQLGRISIPSSISYLDSGVVYIGSSSGDSQLIRLNTEKDQTTDSYVTYLEAFTNIGPVVDFCVVDAEKQGQAQIVTCSGTYRDGSLRIIRNGIGIAEQASIELEGIKGIFPINNNNNNNNNNNNNNNNNNNNNSNGITDSKDRYLITSFIECTKVLSFQGEEIEETEFEGLESNCSTLYCGTIDKLNLLIQITNVSINLIDSNTFKRVSQWNVEPSRRINLVSTNQDQIVLSIDKSLLYFQINSSNKSIQLVKEIELPHEISCIDISPFDSFMDTKSQLVSVGLWNDITLRIFKLPTLEEIWKEPLGGEILPRSILMISFDSIDYIFCSLGDGHLFKFQFDFSSFKLFDKRKLTLGTQPIILKKFKLKNTINIFAISDRPTVIYSHNKKLFYSVVNLKDVTNVTSFNSDGFPNSMAIATTNSLTIGTIDEIQKLHIKTIPLNEEMGRRIVHLEDHSCYAVITVKNNEGLLGGAQDLCEEDEEVSYIRIYNDQTFELISSYKLDPYEMGWSITPCKFAGDDVNTYLAVGTSINTPIKSSGRVLLFSLSSSSSSNDKDSLDNNNNNNNNSGANGKLTLLEEIKFRSSVYFLLSFNGRLIAAVHKRLFSIRYTHSKEKNCKVISSESVHKGHTMILKLASRGHFILVGDMMKSMSLLVEQSDGSLEQIARNPQPIWIRSVAMINDDYFIGAEASNNFIVVKKNNDSTNELERELLDSVGHYHIGESINSMRHGSLVRLPDSDQPIIPTILYASVNGSIGVVASISEEDFIFFSKLQKGLNQVVRGVGGFSHETWRAFSNDHHTIDSKNFIDGDLIETFLDLKYESQLKAVADLGITPDDAFRRIESLMQYIR",
                "length": 1181,
                "header": "sp|B0M0P5-1|DDB1_DICDI Isoform 1 of DNA damage-binding protein 1  OS=Dictyostelium discoideum OX=44689 GN=repE PE=1 SV=1 CANONICAL=B0M0P5-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Differential developmental expression and cell type specificity of Dictyostelium catalases and their response to oxidative stress and UV-light.",
            "journal": "Biochim. Biophys. Acta",
            "date": "2000",
            "authors": "Garcia M X, Foote C, van Es S, Devreotes P N, Alexander S, Alexander H",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "B0M0P5",
                    "url": "https://www.uniprot.org/uniprot/B0M0P5"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11004503",
                    "url": "https://glygen.org/publication/PubMed/11004503"
                }
            ]
        },
        {
            "title": "The genome of the social amoeba Dictyostelium discoideum.",
            "journal": "Nature",
            "date": "2005",
            "authors": "Eichinger L, Pachebat J A, Gl\u00f6ckner G, Rajandream M-A, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov B A, Rivero F, Bankier A T, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, Hauser H, James K, Quiles M, Madan Babu M, Saito T, Buchrieser C, Wardroper A, Felder M, Thangavelu M, Johnson D, Knights A, Loulseged H, Mungall K, Oliver K, Price C, Quail M A, Urushihara H, Hernandez J, Rabbinowitsch E, Steffen D, Sanders M, Ma J, Kohara Y, Sharp S, Simmonds M, Spiegler S, Tivey A, Sugano S, White B, Walker D, Woodward J, Winckler T, Tanaka Y, Shaulsky G, Schleicher M, Weinstock G, Rosenthal A, Cox E C, Chisholm R L, Gibbs R, Loomis W F, Platzer M, Kay R R, Williams J, Dear P H, Noegel A A, Barrell B, Kuspa A",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "B0M0P5",
                    "url": "https://www.uniprot.org/uniprot/B0M0P5"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15875012",
                    "url": "https://glygen.org/publication/PubMed/15875012"
                }
            ]
        },
        {
            "title": "repE--the Dictyostelium homolog of the human xeroderma pigmentosum group E gene is developmentally regulated and contains a leucine zipper motif.",
            "journal": "Nucleic Acids Res.",
            "date": "1996",
            "authors": "Alexander H, Lee S K, Yu S L, Alexander S",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "B0M0P5",
                    "url": "https://www.uniprot.org/uniprot/B0M0P5"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "8710499",
                    "url": "https://glygen.org/publication/PubMed/8710499"
                }
            ]
        },
        {
            "title": "Differential developmental expression of the rep B and rep D xeroderma pigmentosum related DNA helicase genes from Dictyostelium discoideum.",
            "journal": "Nucleic Acids Res.",
            "date": "1997",
            "authors": "Lee S K, Yu S L, Garcia M X, Alexander H, Alexander S",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "B0M0P5",
                    "url": "https://www.uniprot.org/uniprot/B0M0P5"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "9171087",
                    "url": "https://glygen.org/publication/PubMed/9171087"
                }
            ]
        },
        {
            "title": "Rapid changes of nucleotide excision repair gene expression following UV-irradiation and cisplatin treatment of Dictyostelium discoideum.",
            "journal": "Nucleic Acids Res.",
            "date": "1998",
            "authors": "Yu S L, Lee S K, Alexander H, Alexander S",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "B0M0P5",
                    "url": "https://www.uniprot.org/uniprot/B0M0P5"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "9649625",
                    "url": "https://glygen.org/publication/PubMed/9649625"
                }
            ]
        },
        {
            "title": "A mutation in repB, the dictyostelium homolog of the human xeroderma pigmentosum B gene, has increased sensitivity to UV-light but normal morphogenesis.",
            "journal": "Biochim. Biophys. Acta",
            "date": "1998",
            "authors": "Lee S K, Yu S L, Alexander H, Alexander S",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "B0M0P5",
                    "url": "https://www.uniprot.org/uniprot/B0M0P5"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "9765592",
                    "url": "https://glygen.org/publication/PubMed/9765592"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "ddi:DDB_G0286013",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0286013",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-DDI-110314",
            "name": "Recognition of DNA damage by PCNA-containing replication complex",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-110314",
            "resource": "Reactome",
            "description": "Recognition of DNA damage by PCNA-containing replication complex"
        },
        {
            "id": "R-DDI-5696394",
            "name": "DNA Damage Recognition in GG-NER",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-5696394",
            "resource": "Reactome",
            "description": "DNA Damage Recognition in GG-NER"
        },
        {
            "id": "R-DDI-5696395",
            "name": "Formation of Incision Complex in GG-NER",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-5696395",
            "resource": "Reactome",
            "description": "Formation of Incision Complex in GG-NER"
        },
        {
            "id": "R-DDI-6781823",
            "name": "Formation of TC-NER Pre-Incision Complex",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6781823",
            "resource": "Reactome",
            "description": "Formation of TC-NER Pre-Incision Complex"
        },
        {
            "id": "R-DDI-6782135",
            "name": "Dual incision in TC-NER",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6782135",
            "resource": "Reactome",
            "description": "Dual incision in TC-NER"
        },
        {
            "id": "R-DDI-6782210",
            "name": "Gap-filling DNA repair synthesis and ligation in TC-NER",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6782210",
            "resource": "Reactome",
            "description": "Gap-filling DNA repair synthesis and ligation in TC-NER"
        },
        {
            "id": "R-DDI-8951664",
            "name": "Neddylation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8951664",
            "resource": "Reactome",
            "description": "Neddylation"
        }
    ],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "DNA binding",
                        "id": "GO:0003677",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B0M0P5",
                                "url": "https://www.uniprot.org/uniprot/B0M0P5"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B0M0P5",
                                "url": "https://www.uniprot.org/uniprot/B0M0P5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B0M0P5",
                                "url": "https://www.uniprot.org/uniprot/B0M0P5"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "site of double-strand break",
                        "id": "GO:0035861",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035861",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "B0M0P5",
                                "url": "https://www.uniprot.org/uniprot/B0M0P5"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 4,
                "go_terms": [
                    {
                        "name": "DNA repair",
                        "id": "GO:0006281",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281",
                        "evidence": [
                            {
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