{ "uniprot_canonical_ac": "B0G172-1", "uniprot_ac": "B0G172", "uniprot_id": "PGTB2_DICDI", "mass": { "chemical_mass": 38012.0, "monoisotopic_mass": 38012.0 }, "refseq": { "ac": "XP_001733035", "name": "Rab geranylgeranyltransferase beta subunit", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001733035" }, "gene_names": [ { "name": "rabggtb", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/B0G172", "id": "B0G172" }, { "name": "DDB_G0290671", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/B0G172", "id": "B0G172" }, { "name": "rabggtb", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001733035", "id": "XP_001733035" } ], "protein_names": [ { "name": "Probable geranylgeranyl transferase type-2 subunit beta", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "B0G172" }, { "name": "2.5.1.60", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "B0G172" }, { "name": "GGTase-II-beta", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "B0G172" }, { "name": "Geranylgeranyl transferase type II subunit beta", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "B0G172" }, { "name": "Rab GG transferase beta", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "B0G172" }, { "name": "Rab GGTase beta", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "B0G172" }, { "name": "Rab geranyl-geranyltransferase subunit beta", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "B0G172" }, { "name": "Rab geranylgeranyltransferase beta subunit", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001733035", "id": "XP_001733035" }, { "name": "Rab geranylgeranyltransferase subunit beta", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "B0G172" }, { "name": "Type II protein geranyl-geranyltransferase subunit beta", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "B0G172" }, { "name": "protein geranylgeranyltransferase type II", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001733035", "id": "XP_001733035" } ], "function": [ { "annotation": "Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal.", "evidence": [ { "database": "UniProtKB", "id": "B0G172", "url": "https://www.uniprot.org/uniprot/B0G172#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "B0G172", "url": "https://www.uniprot.org/uniprot/B0G172" } ], "common_name": "Cellular slime molds" } ], "gene": [ { "name": "rabggtb", "url": "https://www.uniprot.org/uniprot/B0G172", "locus": {} } ], "crossref": [ { "id": "cd02894", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02894", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "DDB_G0290671", "url": "http://dictybase.org/gene/DDB_G0290671", "database": "dictyBase", "categories": [ "Organism-specific" ] }, { "id": "8627741", "url": "https://www.ncbi.nlm.nih.gov/gene/8627741", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001330", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001330", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008930", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008930", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026873", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026873", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045089", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045089", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0290671", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0290671", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VKRCQCP", "url": "https://omabrowser.org/oma/group/VKRCQCP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11774", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11774", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11774:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11774:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00432", "url": "http://pfam.xfam.org/family/PF00432", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_B0G172", "url": "http://purl.obolibrary.org/obo/PR_B0G172", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DDI-6803205", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6803205", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DDI-8873719", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8873719", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_001733035", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001733035", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "21240", "url": "https://www.rhea-db.org/rhea/21240", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "B0G172", "url": "https://www.uniprot.org/uniprot/B0G172", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B0G172-1", "url": "https://www.uniprot.org/uniprot/B0G172-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTDNINKESTTTTTTIDHTTNLLIDKHVEYIVKLGSKKDSFEYWVTEHIRMNGMYWGLSSLYLLKSLDKLDKNEVIQWLLSCQKSNGGFGGNTSHDDHLLSTLSAVQILIQYDALDKIDINSVVDYVVKLQREDGSFVGDQWGEVDTRFSYAAIMCLSLLKSLDKINCEKAVEYILSCQNFDGGFGSIPGAESHAGQIFTCVGALSILNEINKIDIDKLGWWLSERQLPNGGLNGRPEKSSDVCYSWWVLSALSAIDRLHWIDNDKLKSYILKCQDNETGGIADKPGDIPDVFHTFFGICGLSLMGYFKDQIESIDPVYALGTKTLQKLGLNLPWNKNL", "length": 339, "header": "sp|B0G172-1|PGTB2_DICDI Isoform 1 of Probable geranylgeranyl transferase type-2 subunit beta OS=Dictyostelium discoideum OX=44689 GN=rabggtb PE=3 SV=1 CANONICAL=B0G172-1" }, "isoforms": [ { "isoform_ac": "B0G172-1", "url": "", "sequence": { "sequence": "MTDNINKESTTTTTTIDHTTNLLIDKHVEYIVKLGSKKDSFEYWVTEHIRMNGMYWGLSSLYLLKSLDKLDKNEVIQWLLSCQKSNGGFGGNTSHDDHLLSTLSAVQILIQYDALDKIDINSVVDYVVKLQREDGSFVGDQWGEVDTRFSYAAIMCLSLLKSLDKINCEKAVEYILSCQNFDGGFGSIPGAESHAGQIFTCVGALSILNEINKIDIDKLGWWLSERQLPNGGLNGRPEKSSDVCYSWWVLSALSAIDRLHWIDNDKLKSYILKCQDNETGGIADKPGDIPDVFHTFFGICGLSLMGYFKDQIESIDPVYALGTKTLQKLGLNLPWNKNL", "length": 339, "header": "sp|B0G172-1|PGTB2_DICDI Isoform 1 of Probable geranylgeranyl transferase type-2 subunit beta OS=Dictyostelium discoideum OX=44689 GN=rabggtb PE=3 SV=1 CANONICAL=B0G172-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Eichinger L, Pachebat J A, Gl\u00f6ckner G, Rajandream M-A, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov B A, Rivero F, Bankier A T, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, Hauser H, James K, Quiles M, Madan Babu M, Saito T, Buchrieser C, Wardroper A, Felder M, Thangavelu M, Johnson D, Knights A, Loulseged H, Mungall K, Oliver K, Price C, Quail M A, Urushihara H, Hernandez J, Rabbinowitsch E, Steffen D, Sanders M, Ma J, Kohara Y, Sharp S, Simmonds M, Spiegler S, Tivey A, Sugano S, White B, Walker D, Woodward J, Winckler T, Tanaka Y, Shaulsky G, Schleicher M, Weinstock G, Rosenthal A, Cox E C, Chisholm R L, Gibbs R, Loomis W F, Platzer M, Kay R R, Williams J, Dear P H, Noegel A A, Barrell B, Kuspa A", "evidence": [ { "database": "UniProtKB", "id": "B0G172", "url": "https://www.uniprot.org/uniprot/B0G172" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] } ], "pathway": [ { "id": "ddi:DDB_G0290671", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0290671", "resource": "KEGG Pathway" }, { "id": "R-DDI-6803205", "name": "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6803205", "resource": "Reactome", "description": "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" }, { "id": "R-DDI-8873719", "name": "RAB geranylgeranylation", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8873719", "resource": "Reactome", "description": "RAB geranylgeranylation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "Rab geranylgeranyltransferase activity", "id": "GO:0004663", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004663", "evidence": [ { "database": "UniProtKB", "id": "B0G172", "url": "https://www.uniprot.org/uniprot/B0G172" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "B0G172", "url": "https://www.uniprot.org/uniprot/B0G172" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "B0G172", "url": "https://www.uniprot.org/uniprot/B0G172" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Rab-protein geranylgeranyltransferase complex", "id": "GO:0005968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005968", "evidence": [ { "database": "UniProtKB", "id": "B0G172", "url": "https://www.uniprot.org/uniprot/B0G172" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein geranylgeranylation", "id": "GO:0018344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018344", "evidence": [ { "database": "UniProtKB", "id": "B0G172", "url": "https://www.uniprot.org/uniprot/B0G172" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" }, { "start_pos": 92, "end_pos": 94, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "21240", "name": "", "equation": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P53610-1", "Q04631-1", "Q08602-1", "Q08603-1", "A0A8I6AJR3-1", "P49354-1", "Q92696-1", "P53609-1", "P53611-1", "Q61239-1", "P53612-1", "Q8BUY9-1", "Q9JHK4-1", "P18898-1", "P20133-1", "P29703-1", "Q00618-1", "Q55DA3-1", "Q55DQ4-1", "B0G172-1", "Q54RT9-1", "Q9VN77-1", "Q9XZ68-1" ], "evidence": [ { "id": "21240", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21240" } ] }, { "id": "R-DDI-6801101", "name": "RABGGTA binds RABGGTB", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q55DQ4-1", "B0G172-1" ], "evidence": [ { "id": "R-DDI-6801101", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6801101" } ] }, { "id": "R-DDI-6801109", "name": "CHM binds RGGT", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q55DQ4-1", "B0G172-1" ], "evidence": [ { "id": "R-DDI-6801109", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6801109" } ] }, { "id": "R-DDI-8870457", "name": "FarC-PTP4A2 binds RABGGTB", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54DU9-1", "Q86IL4-1", "B0G172-1" ], "evidence": [ { "id": "R-DDI-8870457", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8870457" } ] }, { "id": "R-DDI-8870461", "name": "RABGGTA and RABGGTB bind", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q54DU9-1", "Q55DQ4-1", "Q86IL4-1", "B0G172-1" ], "evidence": [ { "id": "R-DDI-8870461", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8870461" } ] }, { "id": "R-DDI-8870465", "name": "RGGT binds the RAB-binding subunit", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q55DQ4-1", "B0G172-1" ], "evidence": [ { "id": "R-DDI-8870465", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8870465" } ] }, { "id": "R-DDI-8870466", "name": "RGGT:CHM binds RABs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q55DQ4-1", "B0G172-1", "P36409-1", "P36411-1" ], "evidence": [ { "id": "R-DDI-8870466", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8870466" } ] }, { "id": "R-DDI-8870469", "name": "RGGT geranylgeranylates RAB proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-1131164" ], "output_participant_list": [], "enzyme_list": [ "Q55DQ4-1", "B0G172-1", "P36409-1", "P36411-1" ], "evidence": [ { "id": "R-DDI-8870469", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-8870469" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1131164", "participant_name": "geranylgeranyl diphosphate [cytosol]", "crossref": [ { "id": "48861", "database": "ChEBI", "url": "" }, { "id": "HMDB0004486", "database": "HMDB Metabolite", "url": "" }, { "id": "3052", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "C00353", "database": "COMPOUND", "url": "" }, { "id": "000012495043", "database": "ZINC", "url": "" }, { "id": "HMDB0004486", "database": "HMDB Metabolite", "url": "" }, { "id": "C00353", "database": "COMPOUND", "url": "" }, { "id": "48861", "database": "ChEBI", "url": "" }, { "id": "000012495043", "database": "ZINC", "url": "" }, { "id": "3052", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "HMDB0004486", "database": "HMDB Metabolite", "url": "" }, { "id": "C00353", "database": "COMPOUND", "url": "" }, { "id": "000012495043", "database": "ZINC", "url": "" }, { "id": "3052", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "48861", "database": "ChEBI", "url": "" }, { "id": "48861", "database": "ChEBI", "url": "" }, { "id": "HMDB0004486", "database": "HMDB Metabolite", "url": "" }, { "id": "3052", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "C00353", "database": "COMPOUND", "url": "" }, { "id": "000012495043", "database": "ZINC", "url": "" }, { "id": "000012495043", "database": "ZINC", "url": "" }, { "id": "3052", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "48861", "database": "ChEBI", "url": "" }, { "id": "HMDB0004486", "database": "HMDB Metabolite", "url": "" }, { "id": "C00353", "database": "COMPOUND", "url": "" }, { "id": "HMDB0004486", "database": "HMDB Metabolite", "url": "" }, { "id": "C00353", "database": "COMPOUND", "url": "" }, { "id": "48861", "database": "ChEBI", "url": "" }, { "id": "000012495043", "database": "ZINC", "url": "" }, { "id": "3052", "database": "Guide to Pharmacology - Ligands", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A8I6AJR3", "gene_name": "ENSRNOG00000070626", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein].", "evidence": [ { "id": "A0A8I6AJR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AJR3" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "A0A8I6AJR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AJR3" } ] } ] }, { "uniprot_ac": "B0G172", "gene_name": "rabggtb", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein].", "evidence": [ { "id": "B0G172", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G172" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "B0G172", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G172" } ] } ] }, { "uniprot_ac": "P18898", "gene_name": "CDC43", "activity": [ { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein].", "evidence": [ { "id": "P18898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18898" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "P18898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18898" } ] } ] }, { "uniprot_ac": "P20133", "gene_name": "BET2", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein].", "evidence": [ { "id": "P20133", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20133" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "P20133", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20133" } ] } ] }, { "uniprot_ac": "P29703", "gene_name": "RAM2", "activity": [ { "ec_number": "2.5.1.58", "activity": "(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein].", "evidence": [ { "id": "P29703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29703" } ] }, { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein].", "evidence": [ { "id": "P29703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29703" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "P29703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29703" } ] }, { "ec_number": "2.5.1.58", "activity": "", "evidence": [ { "id": "P29703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29703" } ] } ] }, { "uniprot_ac": "P36409", "gene_name": "rab2A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P36409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36409" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P36409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36409" } ] } ] }, { "uniprot_ac": "P36411", "gene_name": "rab7A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P36411", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36411" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P36411", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36411" } ] } ] }, { "uniprot_ac": "P49354", "gene_name": "FNTA", "activity": [ { "ec_number": "2.5.1.58", "activity": "(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein].", "evidence": [ { "id": "P49354", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49354" } ] }, { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein].", "evidence": [ { "id": "P49354", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49354" } ] }, { "ec_number": "2.5.1.58", "activity": "", "evidence": [ { "id": "P49354", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49354" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "P49354", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49354" } ] } ] }, { "uniprot_ac": "P53609", "gene_name": "PGGT1B", "activity": [ { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein].", "evidence": [ { "id": "P53609", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53609" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "P53609", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53609" } ] } ] }, { "uniprot_ac": "P53610", "gene_name": "Pggt1b", "activity": [ { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein].", "evidence": [ { "id": "P53610", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53610" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "P53610", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53610" } ] } ] }, { "uniprot_ac": "P53611", "gene_name": "RABGGTB", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein].", "evidence": [ { "id": "P53611", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53611" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "P53611", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53611" } ] } ] }, { "uniprot_ac": "P53612", "gene_name": "Rabggtb", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein].", "evidence": [ { "id": "P53612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53612" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "P53612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53612" } ] } ] }, { "uniprot_ac": "Q00618", "gene_name": "BET4", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein].", "evidence": [ { "id": "Q00618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00618" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "Q00618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00618" } ] } ] }, { "uniprot_ac": "Q04631", "gene_name": "Fnta", "activity": [ { "ec_number": "2.5.1.58", "activity": "(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein].", "evidence": [ { "id": "Q04631", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04631" } ] }, { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein].", "evidence": [ { "id": "Q04631", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04631" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "Q04631", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04631" } ] }, { "ec_number": "2.5.1.58", "activity": "", "evidence": [ { "id": "Q04631", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04631" } ] } ] }, { "uniprot_ac": "Q08602", "gene_name": "Rabggta", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein].", "evidence": [ { "id": "Q08602", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08602" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "Q08602", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08602" } ] } ] }, { "uniprot_ac": "Q08603", "gene_name": "Rabggtb", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein].", "evidence": [ { "id": "Q08603", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08603" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "Q08603", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08603" } ] } ] }, { "uniprot_ac": "Q54DU9", "gene_name": "", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q54DU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54DU9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q54DU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54DU9" } ] } ] }, { "uniprot_ac": "Q54RT9", "gene_name": "fntA", "activity": [ { "ec_number": "2.5.1.58", "activity": "(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein].", "evidence": [ { "id": "Q54RT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54RT9" } ] }, { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein].", "evidence": [ { "id": "Q54RT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54RT9" } ] }, { "ec_number": "2.5.1.58", "activity": "", "evidence": [ { "id": "Q54RT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54RT9" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "Q54RT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54RT9" } ] } ] }, { "uniprot_ac": "Q55DA3", "gene_name": "pggt1b", "activity": [ { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein].", "evidence": [ { "id": "Q55DA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55DA3" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "Q55DA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55DA3" } ] } ] }, { "uniprot_ac": "Q55DQ4", "gene_name": "rabggta", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein].", "evidence": [ { "id": "Q55DQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55DQ4" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "Q55DQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55DQ4" } ] } ] }, { "uniprot_ac": "Q61239", "gene_name": "Fnta", "activity": [ { "ec_number": "2.5.1.58", "activity": "(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein].", "evidence": [ { "id": "Q61239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61239" } ] }, { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein].", "evidence": [ { "id": "Q61239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61239" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "Q61239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61239" } ] }, { "ec_number": "2.5.1.58", "activity": "", "evidence": [ { "id": "Q61239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61239" } ] } ] }, { "uniprot_ac": "Q86IL4", "gene_name": "", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q86IL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86IL4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q86IL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86IL4" } ] } ] }, { "uniprot_ac": "Q8BUY9", "gene_name": "Pggt1b", "activity": [ { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein].", "evidence": [ { "id": "Q8BUY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BUY9" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "Q8BUY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BUY9" } ] } ] }, { "uniprot_ac": "Q92696", "gene_name": "RABGGTA", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein].", "evidence": [ { "id": "Q92696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92696" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "Q92696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92696" } ] } ] }, { "uniprot_ac": "Q9JHK4", "gene_name": "Rabggta", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein].", "evidence": [ { "id": "Q9JHK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JHK4" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "Q9JHK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JHK4" } ] } ] }, { "uniprot_ac": "Q9VN77", "gene_name": "RabGGTa", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein].", "evidence": [ { "id": "Q9VN77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VN77" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "Q9VN77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VN77" } ] } ] }, { "uniprot_ac": "Q9XZ68", "gene_name": "RabGGTb", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein].", "evidence": [ { "id": "Q9XZ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9XZ68" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "Q9XZ68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9XZ68" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 277, "end_pos": 279 }, { "start_pos": 92, "end_pos": 94 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }