{ "uniprot_canonical_ac": "B0G140-1", "uniprot_ac": "B0G140", "uniprot_id": "ATG17_DICDI", "mass": { "chemical_mass": 57014.0, "monoisotopic_mass": 57014.0 }, "refseq": { "ac": "XP_001733002", "name": "autophagy-related protein 17", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001733002" }, "gene_names": [ { "name": "atg17", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/B0G140", "id": "B0G140" }, { "name": "DDB_G0295673", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/B0G140", "id": "B0G140" }, { "name": "atg17", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001733002", "id": "XP_001733002" } ], "protein_names": [ { "name": "Probable autophagy-related protein 17", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "B0G140" }, { "name": "autophagy-related protein 17", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001733002", "id": "XP_001733002" } ], "function": [ { "annotation": "Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "B0G140", "url": "https://www.uniprot.org/uniprot/B0G140#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "B0G140", "url": "https://www.uniprot.org/uniprot/B0G140" } ], "common_name": "Cellular slime molds" } ], "gene": [ { "name": "atg17", "url": "https://www.uniprot.org/uniprot/B0G140", "locus": {} } ], "crossref": [ { "id": "DDB_G0295673", "url": "http://dictybase.org/gene/DDB_G0295673", "database": "dictyBase", "categories": [ "Organism-specific" ] }, { "id": "8623455", "url": "https://www.ncbi.nlm.nih.gov/gene/8623455", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007240", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007240", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045326", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045326", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0295673", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0295673", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QCDFITF", "url": "https://omabrowser.org/oma/group/QCDFITF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR28005", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28005", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28005:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28005:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04108", "url": "http://pfam.xfam.org/family/PF04108", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_B0G140", "url": "http://purl.obolibrary.org/obo/PR_B0G140", "database": "PRO", "categories": [ "Protein" ] }, { "id": "XP_001733002", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001733002", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "B0G140", "url": "https://www.uniprot.org/uniprot/B0G140", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B0G140-1", "url": "https://www.uniprot.org/uniprot/B0G140-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDFSSKSLELCKSHSNQTDQLLKISKQTYEKYDNSLSKLHLIIRELNKQLIILKETSTQFNDRYNTFINDFTSLSNQKQSLFTSIENKLEILKKKYLDKGLVFKNNNNNNNNNNNNNNNNNNNSNKSTEDDNNENNNNNDVNKNNNNNNNNNLNTLYDFIDIESLELIKNQFLSELSGLNEICDKSKQIYKSTNESNLEMENRFLEIQKQYNKQIEESNSLSDLLTQQNNLYKTIQNQLINVASQCDFITFYKPSPSPLSPSPSPSSSSSSSSPSPSSPQQQHDFNINNKKEQIQLLLTSSLENIQLMSKNVKDIENQFKESCSIYTLVYLLNEKLSFGNDFSENWETFERFNCIFEQRLAGANYFIGELYSLGKWYDLFDESYDNLLEEVKRRQKEYLRQKTIAEQFNEELKHNYNQEIQNRLKFYDSYGKYLPVSLFSTISDQPISFQVKQIIEESVIDYSFNPLNLKRSSPINQQQQQQQPPPNS", "length": 488, "header": "sp|B0G140-1|ATG17_DICDI Isoform 1 of Probable autophagy-related protein 17 OS=Dictyostelium discoideum OX=44689 GN=atg17 PE=3 SV=1 CANONICAL=B0G140-1" }, "isoforms": [ { "isoform_ac": "B0G140-1", "url": "", "sequence": { "sequence": "MDFSSKSLELCKSHSNQTDQLLKISKQTYEKYDNSLSKLHLIIRELNKQLIILKETSTQFNDRYNTFINDFTSLSNQKQSLFTSIENKLEILKKKYLDKGLVFKNNNNNNNNNNNNNNNNNNNSNKSTEDDNNENNNNNDVNKNNNNNNNNNLNTLYDFIDIESLELIKNQFLSELSGLNEICDKSKQIYKSTNESNLEMENRFLEIQKQYNKQIEESNSLSDLLTQQNNLYKTIQNQLINVASQCDFITFYKPSPSPLSPSPSPSSSSSSSSPSPSSPQQQHDFNINNKKEQIQLLLTSSLENIQLMSKNVKDIENQFKESCSIYTLVYLLNEKLSFGNDFSENWETFERFNCIFEQRLAGANYFIGELYSLGKWYDLFDESYDNLLEEVKRRQKEYLRQKTIAEQFNEELKHNYNQEIQNRLKFYDSYGKYLPVSLFSTISDQPISFQVKQIIEESVIDYSFNPLNLKRSSPINQQQQQQQPPPNS", "length": 488, "header": "sp|B0G140-1|ATG17_DICDI Isoform 1 of Probable autophagy-related protein 17 OS=Dictyostelium discoideum OX=44689 GN=atg17 PE=3 SV=1 CANONICAL=B0G140-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Eichinger L, Pachebat J A, Gl\u00f6ckner G, Rajandream M-A, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov B A, Rivero F, Bankier A T, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, Hauser H, James K, Quiles M, Madan Babu M, Saito T, Buchrieser C, Wardroper A, Felder M, Thangavelu M, Johnson D, Knights A, Loulseged H, Mungall K, Oliver K, Price C, Quail M A, Urushihara H, Hernandez J, Rabbinowitsch E, Steffen D, Sanders M, Ma J, Kohara Y, Sharp S, Simmonds M, Spiegler S, Tivey A, Sugano S, White B, Walker D, Woodward J, Winckler T, Tanaka Y, Shaulsky G, Schleicher M, Weinstock G, Rosenthal A, Cox E C, Chisholm R L, Gibbs R, Loomis W F, Platzer M, Kay R R, Williams J, Dear P H, Noegel A A, Barrell B, Kuspa A", "evidence": [ { "database": "UniProtKB", "id": "B0G140", "url": "https://www.uniprot.org/uniprot/B0G140" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] } ], "pathway": [ { "id": "ddi:DDB_G0295673", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0295673", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "molecular adaptor activity", "id": "GO:0060090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "database": "UniProtKB", "id": "B0G140", "url": "https://www.uniprot.org/uniprot/B0G140" } ], "pmid": "" }, { "name": "protein kinase activator activity", "id": "GO:0030295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030295", "evidence": [ { "database": "UniProtKB", "id": "B0G140", "url": "https://www.uniprot.org/uniprot/B0G140" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "autophagosome assembly", "id": "GO:0000045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000045", "evidence": [ { "database": "UniProtKB", "id": "B0G140", "url": "https://www.uniprot.org/uniprot/B0G140" } ], "pmid": "" }, { "name": "autophagy of peroxisome", "id": "GO:0030242", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030242", "evidence": [ { "database": "UniProtKB", "id": "B0G140", "url": "https://www.uniprot.org/uniprot/B0G140" } ], "pmid": "" }, { "name": "autophagy of mitochondrion", "id": "GO:0000422", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000422", "evidence": [ { "database": "UniProtKB", "id": "B0G140", "url": "https://www.uniprot.org/uniprot/B0G140" } ], "pmid": "" }, { "name": "late nucleophagy", "id": "GO:0044805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044805", "evidence": [ { "database": "UniProtKB", "id": "B0G140", "url": "https://www.uniprot.org/uniprot/B0G140" } ], "pmid": "" }, { "name": "piecemeal microautophagy of the nucleus", "id": "GO:0034727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034727", "evidence": [ { "database": "UniProtKB", "id": "B0G140", "url": "https://www.uniprot.org/uniprot/B0G140" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "B0G140", "url": "https://www.uniprot.org/uniprot/B0G140" } ], "pmid": "" }, { "name": "phagophore assembly site membrane", "id": "GO:0034045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034045", "evidence": [ { "database": "UniProtKB", "id": "B0G140", "url": "https://www.uniprot.org/uniprot/B0G140" } ], "pmid": "" }, { "name": "phagophore assembly site", "id": "GO:0000407", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000407", "evidence": [ { "database": "UniProtKB", "id": "B0G140", "url": "https://www.uniprot.org/uniprot/B0G140" } ], "pmid": "" }, { "name": "Atg1/ULK1 kinase complex", "id": "GO:1990316", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990316", "evidence": [ { "database": "UniProtKB", "id": "B0G140", "url": "https://www.uniprot.org/uniprot/B0G140" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" }, { "start_pos": 125, "end_pos": 127, "annotation": "n_glycosylation_sequon" }, { "start_pos": 16, "end_pos": 18, "annotation": "n_glycosylation_sequon" }, { "start_pos": 194, "end_pos": 196, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 122, "end_pos": 124 }, { "start_pos": 125, "end_pos": 127 }, { "start_pos": 16, "end_pos": 18 }, { "start_pos": 194, "end_pos": 196 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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