{ "uniprot_canonical_ac": "B0G138-1", "uniprot_ac": "B0G138", "uniprot_id": "PKS21_DICDI", "mass": { "chemical_mass": 314195.0, "monoisotopic_mass": 314195.0 }, "refseq": { "ac": "XP_001733001", "name": "beta-ketoacyl synthase family protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001733001" }, "gene_names": [ { "name": "pks21", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/B0G138", "id": "B0G138" }, { "name": "DDB_G0282029", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/B0G138", "id": "B0G138" }, { "name": "pks21", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001733001", "id": "XP_001733001" } ], "protein_names": [ { "name": "Probable polyketide synthase 21", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "B0G138" }, { "name": "2.3.1.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "B0G138" }, { "name": "beta-ketoacyl synthase family protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001733001", "id": "XP_001733001" }, { "name": "dipks21", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "B0G138" } ], "function": [ { "annotation": "Probable polyketide synthase.", "evidence": [ { "database": "UniProtKB", "id": "B0G138", "url": "https://www.uniprot.org/uniprot/B0G138#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "B0G138", "url": "https://www.uniprot.org/uniprot/B0G138" } ], "common_name": "Cellular slime molds" } ], "gene": [ { "name": "pks21", "url": "https://www.uniprot.org/uniprot/B0G138", "locus": {} } ], "crossref": [ { "id": "cd00833", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00833", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05195", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05195", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05235", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05235", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08954", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08954", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "DDB_G0282029", "url": "http://dictybase.org/gene/DDB_G0282029", "database": "dictyBase", "categories": [ "Organism-specific" ] }, { "id": "8623374", "url": "https://www.ncbi.nlm.nih.gov/gene/8623374", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001227", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001227", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009081", "url": 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"id": "PTHR45681:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45681:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00109", "url": "http://pfam.xfam.org/family/PF00109", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00698", "url": "http://pfam.xfam.org/family/PF00698", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02801", "url": "http://pfam.xfam.org/family/PF02801", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07993", "url": "http://pfam.xfam.org/family/PF07993", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08659", "url": "http://pfam.xfam.org/family/PF08659", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13602", "url": "http://pfam.xfam.org/family/PF13602", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16197", "url": "http://pfam.xfam.org/family/PF16197", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_B0G138", "url": "http://purl.obolibrary.org/obo/PR_B0G138", "database": "PRO", "categories": [ "Protein" ] }, { "id": "XP_001733001", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001733001", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "B0G138", "url": "https://www.uniprot.org/uniprot/B0G138", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B0G138-1", "url": "https://www.uniprot.org/uniprot/B0G138-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKLENKEIAIVGIGFRIPQGKESINNGSVSHLWNNLKNGFSGIVETSERWSDNINLLGEVNNKFGGLLPLKEWSDFDPVHFAINPSEVPLMDPQTRLLLKCTWEALEDAFIDPIDIRGSNTSCFIGCSTLDYSTTNRDFNETSENYFASNVLHTISNRLSFSYDIRGPSMTIDTACSSSLNSIAMGFQSIQNGTSNLSIVGGVSLLLDPYISKSFSFLNMLSKKGKCKPFDSEADGYIRAESCGIVILKPLSDAIRDGNNIYCVINSFSSNVDGGGLNDKSNFYSPSKQSQSDNIKLALKSANMKASDISFVECHGTGTPTGDPIEVEGVSMALNSSKTSTPSKPLLIGSLKSNIGHSEAASGVASLIKCCLMFKNKHYAPNVNFDQPNPKINFKDWNIKVVTEAIPFTNNNEKPVSMVINNFGVTGSNCCLILSQFIEQSINQNGNGHSYPAESQQQQQQRFLIPFSANSVKSLKNYEDLIINDIKISTNSFKEFVKNQIYSKSKKLYQRSVLISSNWDQLKTKNKYFKTNNDKSSNITIKRNQPLVVIVFGGQGSQWNKMAQQLYECEPIFRSSMDKFNKELSKYYGYSVLDKLRSIKDDDIISIHQPIIAQPSILMLQISLFELYKHWGINVSFIVGHSLGEIATSYCSGMVDFQTVCKLIYHRSISQNNTNGCGKMLSVNISHSEFIELYSNKYPTIEVACYNSPTSIVIAGNENILKEISLNLKENNIFCAFLGSLSSFHTSSQHSTKNEILPLDIPSKQSRIPTFSTVTTNLFNHETTPFNSSYVYENIIQPVRFSQTISNLYQHIENNKLGNELIFIEVSPHPSLSFYLKQMIPKSSSYFNSVSVLTSTNKKNSNDLDEIHSTISQIYCLGYDVNFKCQFNHNDDDVSSIRNSKVNISLPNYQFDEQHYWKVDINFEQYRLNGPNVFNSLGKSMINYSSNNKSYESIIDINRNPFKYLKDHIVKGKYYFPGIGYADNIMKLYPNQDIIINNLEFLAPFVLKENVKHTLQTNVYQLGNTDYRVTFNIKDNKTNQWVQTCTGNFQLISLKDNNNDHSSKYDINQLLSECNFTTLSKQEVYKHSRSITGITHLGAFQGIEELYFGNDCIISKIQVNTENFDIDGKPVYQTYDKSFFNTALLDSCSQTIVGFITNSSQFVFERLEGLKVYSENIPTDKLKYKNIYCQAKFISLESDSYKSSVLVLLEDGTKLLEMDCISLHSTLPLLNSLLINNPTTELFTNNLQCKDSLVNILSIDNNQTFSSISSSNTVTEIIKQTIKPIINEKIVFRILQSFSDLELSKQIIETLNQIFDDNSLQEIDIEFTIIDNSNDKLPTLHDSSLIFKNDITQLKPSYYDIIINNNNDGDDETIIKSIFNILSSNGLLLIIGDDIGDKYNIDSLINLGFNENKIQKSNKVIQSQKSTILSNELTVVPNNKNDNIIIYCEKESKYTNEFMKLISNNHISCKQTIISNINEFNQLLPSITNDSIIYFIKSMEQLEMNNFKQITMEYIEINQQLLKHSLTCKHVLITIDSQIKNYLSSSIIGTARYFNEFPSLNLYSIDFDNQLSISSLLNKIINQLIENSNNHIQREYIIRNNSIYYEILKNEKNIKSNFNSNSFEDNDFMTLLDSTNLEYKLASKPKKLKKNQIEVKVLATGINYKDYLIYRGLVVIDENVSISKNPLGLEFSGIITRISNENQNCEFKVGDNVFGIACDTTASHVIADVLYVSHKPENISHVEAASLPVIFSTCLHGMFNIGNFNIDDDEVILIHSATGGIGLATLEILKWKGHKSPIFVTVGSKDKEQYLIDNYGSFITGIYSSRNKNYVNEIKSKLNQLYGTTGKFNGVDLIINTLPNEFTHSNFLCLKERGKIIDLSITHLNNNEFLNFNNFKFNKSYHNIELMHINKKVVSRLLKSISNALNENKLKPIPITTFQIEDVKEAIEYINQRKHIGKIVLDHSCSNGSIGSDGLLNQLIESDNNEKNHTILKYDFKIDTKNIIGKNIIITGQSGIILEILKWLIKYSPTESFENIIILSKSSLKWELELLINKTISRKDNNTKFHFKSVDVGDPIEMRKSINQILLENPNIDNIDSIFHYAFAQITKEVEEIDIESLDISHNAKTMGAINLHEISIEKSWKLKQFVMASSIASLFGSFNQCSYVSANLVLDSLSRYRKSIGLPSTCTNWGAIKSAGFVSRNELVSKMLDDQGFIPIPTNIILGSLDLQLQNSNKNSNLIVSKFNYDSIKKLSSETSTFQRLDFILNSIKEKDNDSNGGENSVSESIQTKILNKISELLSIEQSKINTDIRLSDYGADSLTSVQLKNFIDKDIKSNVITLQQLQNNTIDMNIQTILEQIKKLDSNETKGKSKNIIKKDSAPTLDYWRNEMKLDESIQAIKMNPIDFRNDSKVFLTGATGFLGVHLLSNLIKSPNCSVVYCLIRNKKSEPNPINAIINNLKHHKLYHFHNEFELSKIKVIVGNLASPLLGLSKLDFDYISNQINLIINSGADINLASNYEESKVVNIGGFIELIKLSTTGDYQKPIVGFSSVSVFFNASNCKEFDEETVIPTIENINNLPGGYMKSKVVVENLLREVAKRGIPSMLIRPPIIFSHEETGIGHDSDFFQLIIQSCYAVKKYPKIDKNILTSPIGWISLNTIKMIGNEKCWNKSSSNQLNIYSLNSEVSAMNPSFSFLEKQYGCEMVEYEQWKNIINQSKILSCVKLKTFHSLDDLYNIYNLGNGFGVSKKTKELLQSMNSYEGGMVNEKMIQNHINYIFKN", "length": 2779, "header": "sp|B0G138-1|PKS21_DICDI Isoform 1 of Probable polyketide synthase 21 OS=Dictyostelium discoideum OX=44689 GN=pks21 PE=3 SV=1 CANONICAL=B0G138-1" }, "isoforms": [ { "isoform_ac": "B0G138-1", "url": "", "sequence": { "sequence": "MKLENKEIAIVGIGFRIPQGKESINNGSVSHLWNNLKNGFSGIVETSERWSDNINLLGEVNNKFGGLLPLKEWSDFDPVHFAINPSEVPLMDPQTRLLLKCTWEALEDAFIDPIDIRGSNTSCFIGCSTLDYSTTNRDFNETSENYFASNVLHTISNRLSFSYDIRGPSMTIDTACSSSLNSIAMGFQSIQNGTSNLSIVGGVSLLLDPYISKSFSFLNMLSKKGKCKPFDSEADGYIRAESCGIVILKPLSDAIRDGNNIYCVINSFSSNVDGGGLNDKSNFYSPSKQSQSDNIKLALKSANMKASDISFVECHGTGTPTGDPIEVEGVSMALNSSKTSTPSKPLLIGSLKSNIGHSEAASGVASLIKCCLMFKNKHYAPNVNFDQPNPKINFKDWNIKVVTEAIPFTNNNEKPVSMVINNFGVTGSNCCLILSQFIEQSINQNGNGHSYPAESQQQQQQRFLIPFSANSVKSLKNYEDLIINDIKISTNSFKEFVKNQIYSKSKKLYQRSVLISSNWDQLKTKNKYFKTNNDKSSNITIKRNQPLVVIVFGGQGSQWNKMAQQLYECEPIFRSSMDKFNKELSKYYGYSVLDKLRSIKDDDIISIHQPIIAQPSILMLQISLFELYKHWGINVSFIVGHSLGEIATSYCSGMVDFQTVCKLIYHRSISQNNTNGCGKMLSVNISHSEFIELYSNKYPTIEVACYNSPTSIVIAGNENILKEISLNLKENNIFCAFLGSLSSFHTSSQHSTKNEILPLDIPSKQSRIPTFSTVTTNLFNHETTPFNSSYVYENIIQPVRFSQTISNLYQHIENNKLGNELIFIEVSPHPSLSFYLKQMIPKSSSYFNSVSVLTSTNKKNSNDLDEIHSTISQIYCLGYDVNFKCQFNHNDDDVSSIRNSKVNISLPNYQFDEQHYWKVDINFEQYRLNGPNVFNSLGKSMINYSSNNKSYESIIDINRNPFKYLKDHIVKGKYYFPGIGYADNIMKLYPNQDIIINNLEFLAPFVLKENVKHTLQTNVYQLGNTDYRVTFNIKDNKTNQWVQTCTGNFQLISLKDNNNDHSSKYDINQLLSECNFTTLSKQEVYKHSRSITGITHLGAFQGIEELYFGNDCIISKIQVNTENFDIDGKPVYQTYDKSFFNTALLDSCSQTIVGFITNSSQFVFERLEGLKVYSENIPTDKLKYKNIYCQAKFISLESDSYKSSVLVLLEDGTKLLEMDCISLHSTLPLLNSLLINNPTTELFTNNLQCKDSLVNILSIDNNQTFSSISSSNTVTEIIKQTIKPIINEKIVFRILQSFSDLELSKQIIETLNQIFDDNSLQEIDIEFTIIDNSNDKLPTLHDSSLIFKNDITQLKPSYYDIIINNNNDGDDETIIKSIFNILSSNGLLLIIGDDIGDKYNIDSLINLGFNENKIQKSNKVIQSQKSTILSNELTVVPNNKNDNIIIYCEKESKYTNEFMKLISNNHISCKQTIISNINEFNQLLPSITNDSIIYFIKSMEQLEMNNFKQITMEYIEINQQLLKHSLTCKHVLITIDSQIKNYLSSSIIGTARYFNEFPSLNLYSIDFDNQLSISSLLNKIINQLIENSNNHIQREYIIRNNSIYYEILKNEKNIKSNFNSNSFEDNDFMTLLDSTNLEYKLASKPKKLKKNQIEVKVLATGINYKDYLIYRGLVVIDENVSISKNPLGLEFSGIITRISNENQNCEFKVGDNVFGIACDTTASHVIADVLYVSHKPENISHVEAASLPVIFSTCLHGMFNIGNFNIDDDEVILIHSATGGIGLATLEILKWKGHKSPIFVTVGSKDKEQYLIDNYGSFITGIYSSRNKNYVNEIKSKLNQLYGTTGKFNGVDLIINTLPNEFTHSNFLCLKERGKIIDLSITHLNNNEFLNFNNFKFNKSYHNIELMHINKKVVSRLLKSISNALNENKLKPIPITTFQIEDVKEAIEYINQRKHIGKIVLDHSCSNGSIGSDGLLNQLIESDNNEKNHTILKYDFKIDTKNIIGKNIIITGQSGIILEILKWLIKYSPTESFENIIILSKSSLKWELELLINKTISRKDNNTKFHFKSVDVGDPIEMRKSINQILLENPNIDNIDSIFHYAFAQITKEVEEIDIESLDISHNAKTMGAINLHEISIEKSWKLKQFVMASSIASLFGSFNQCSYVSANLVLDSLSRYRKSIGLPSTCTNWGAIKSAGFVSRNELVSKMLDDQGFIPIPTNIILGSLDLQLQNSNKNSNLIVSKFNYDSIKKLSSETSTFQRLDFILNSIKEKDNDSNGGENSVSESIQTKILNKISELLSIEQSKINTDIRLSDYGADSLTSVQLKNFIDKDIKSNVITLQQLQNNTIDMNIQTILEQIKKLDSNETKGKSKNIIKKDSAPTLDYWRNEMKLDESIQAIKMNPIDFRNDSKVFLTGATGFLGVHLLSNLIKSPNCSVVYCLIRNKKSEPNPINAIINNLKHHKLYHFHNEFELSKIKVIVGNLASPLLGLSKLDFDYISNQINLIINSGADINLASNYEESKVVNIGGFIELIKLSTTGDYQKPIVGFSSVSVFFNASNCKEFDEETVIPTIENINNLPGGYMKSKVVVENLLREVAKRGIPSMLIRPPIIFSHEETGIGHDSDFFQLIIQSCYAVKKYPKIDKNILTSPIGWISLNTIKMIGNEKCWNKSSSNQLNIYSLNSEVSAMNPSFSFLEKQYGCEMVEYEQWKNIINQSKILSCVKLKTFHSLDDLYNIYNLGNGFGVSKKTKELLQSMNSYEGGMVNEKMIQNHINYIFKN", "length": 2779, "header": "sp|B0G138-1|PKS21_DICDI Isoform 1 of Probable polyketide synthase 21 OS=Dictyostelium discoideum OX=44689 GN=pks21 PE=3 SV=1 CANONICAL=B0G138-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Eichinger L, Pachebat J A, Gl\u00f6ckner G, Rajandream M-A, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov B A, Rivero F, Bankier A T, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, Hauser H, James K, Quiles M, Madan Babu M, Saito T, Buchrieser C, Wardroper A, Felder M, Thangavelu M, Johnson D, Knights A, Loulseged H, Mungall K, Oliver K, Price C, Quail M A, Urushihara H, Hernandez J, Rabbinowitsch E, Steffen D, Sanders M, Ma J, Kohara Y, Sharp S, Simmonds M, Spiegler S, Tivey A, Sugano S, White B, Walker D, Woodward J, Winckler T, Tanaka Y, Shaulsky G, Schleicher M, Weinstock G, Rosenthal A, Cox E C, Chisholm R L, Gibbs R, Loomis W F, Platzer M, Kay R R, Williams J, Dear P H, Noegel A A, Barrell B, Kuspa A", "evidence": [ { "database": "UniProtKB", "id": "B0G138", "url": "https://www.uniprot.org/uniprot/B0G138" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] }, { "title": "Polyketide synthase genes and the natural products potential of Dictyostelium discoideum.", "journal": "Bioinformatics", "date": "2007", "authors": "Zucko J, Skunca N, Curk T, Zupan B, Long P F, Cullum J, Kessin R H, Hranueli D", "evidence": [ { "database": "UniProtKB", "id": "B0G138", "url": "https://www.uniprot.org/uniprot/B0G138" } ], "reference": [ { "type": "PubMed", "id": "17660200", "url": "https://glygen.org/publication/PubMed/17660200" } ] } ], "pathway": [ { "id": "ddi:DDB_G0282029", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0282029", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "fatty acid biosynthetic process", "id": "GO:0006633", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006633", "evidence": [ { "database": "UniProtKB", "id": "B0G138", "url": "https://www.uniprot.org/uniprot/B0G138" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "B0G138", "url": "https://www.uniprot.org/uniprot/B0G138" } ], "pmid": "" }, 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