{
    "uniprot_canonical_ac": "A6NL99-1",
    "uniprot_ac": "A6NL99",
    "uniprot_id": "AQP73_HUMAN",
    "mass": {
        "chemical_mass": 37357.0,
        "monoisotopic_mass": 37357.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "AQP7P3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A6NL99",
            "id": "A6NL99"
        }
    ],
    "protein_names": [
        {
            "name": "Putative aquaporin-7-like protein 3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "A6NL99"
        }
    ],
    "function": [],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [
        {
            "significant": "Yes",
            "trend": "down",
            "name": "Breast cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:1612",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "A6NL99",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NL99"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:1612",
                    "recommended_name": {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "breast cancer",
                        "description": "A thoracic cancer that originates in the mammary gland."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "breast tumor",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "malignant neoplasm of breast",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "malignant tumor of the breast",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "mammary cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "mammary tumor",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "primary breast cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "hereditary breast carcinoma",
                            "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, lobular, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, protection against, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial breast cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial breast carcinoma",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial cancer of breast",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial cancer of the breast",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "hereditary breast cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "hereditary breast carcinoma",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, familial",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, familial Male",
                            "description": ""
                        },
                        {
                            "id": "MIM:114480",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/114480",
                            "name": "Breast cancer",
                            "description": "Breast cancer"
                        }
                    ]
                }
            ]
        },
        {
            "significant": "Yes",
            "trend": "down",
            "name": "Kidney cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:263",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "A6NL99",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NL99"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:263",
                    "recommended_name": {
                        "id": "DOID:263",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:263",
                        "name": "kidney cancer",
                        "description": "A urinary system cancer that is located_in the kidney."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:263",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:263",
                            "name": "malignant neoplasm of kidney except pelvis",
                            "description": ""
                        },
                        {
                            "id": "DOID:263",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:263",
                            "name": "malignant tumour of kidney",
                            "description": ""
                        },
                        {
                            "id": "DOID:263",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:263",
                            "name": "renal cancer",
                            "description": ""
                        }
                    ]
                }
            ]
        },
        {
            "significant": "Yes",
            "trend": "down",
            "name": "Liver cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:3571",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "A6NL99",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A6NL99"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:3571",
                    "recommended_name": {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "liver cancer",
                        "description": "A hepatobiliary system cancer that is located_in the liver."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "Ca liver - primary",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "Resectable malignant neoplasm of Liver",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "hepatic cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "hepatic neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "malignant hepato-biliary neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "malignant neoplasm of liver",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "malignant neoplasm of liver, primary",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "malignant tumor of liver",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "neoplasm of liver",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "non-resectable primary hepatic malignant neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "primary liver cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "primary malignant neoplasm of liver",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "resectable malignant neoplasm of the liver",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "malignant neoplasm of liver, not specified as primary or secondary",
                            "description": ""
                        }
                    ]
                }
            ]
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A6NL99",
                    "url": "https://www.uniprot.org/uniprot/A6NL99"
                }
            ],
            "common_name": "Human"
        }
    ],
    "gene": [
        {
            "name": "AQP7P3",
            "url": "https://www.uniprot.org/uniprot/A6NL99",
            "locus": {}
        }
    ],
    "crossref": [
        {
            "id": "cd00333",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00333",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "AQP7P3",
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=AQP7P3",
            "database": "GeneCards",
            "categories": [
                "Gene Annotation",
                "Organism-specific"
            ]
        },
        {
            "id": "31976",
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=31976",
            "database": "HGNC",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A6NL99",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A6NL99*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR000425",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000425",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR023271",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR023271",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NX_A6NL99",
            "url": "https://www.nextprot.org/entry/NX_A6NL99",
            "database": "neXtProt",
            "categories": [
                "Protein",
                "Organism-specific"
            ]
        },
        {
            "id": "A6NL99",
            "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A6NL99",
            "database": "O-GlcNAc Database",
            "categories": [
                "Glycoproteomics"
            ]
        },
        {
            "id": "PTHR43829",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43829",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR43829:SF25",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43829:SF25",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00230",
            "url": "http://pfam.xfam.org/family/PF00230",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "A6NL99",
            "url": "https://pharos.nih.gov/targets/A6NL99",
            "database": "PHAROS",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A6NL99",
            "url": "https://www.uniprot.org/uniprot/A6NL99",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A6NL99-1",
            "url": "https://www.uniprot.org/uniprot/A6NL99-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MVQASGHRRSTRGSKMVSWSVIAKIQEICERKMAREFLAEFMSTYVMMVFGLGSVAHMLLNKTFGSYLGVNLGFGFGVTMGVHMAGRTSGAHMNAAVSLTNCALGRVPWRKFPVYVLGQFLGSFLAAATIYSLFYTAILHFSGGELMVTGPVATVGIFATYLPDHMTLWRGFLNEEWLTGMLQLCLFAIVDQENNPALPGTHALVIGILVVIIRVYHGMNTGYAINPSRDLPPRIFTFIAGWGKLVFSDGENLWWVPVVAPLLGASLGGIIYLVFIGSTIPREPLKLEDSVAYEDHGITVLPKMGSHEPMISPLTLISVSPANRSSVHPAPPLHESMALEHF",
        "length": 342,
        "header": "sp|A6NL99-1|AQP73_HUMAN Isoform 1 of Putative aquaporin-7-like protein 3  OS=Homo sapiens OX=9606 GN=AQP7P3 PE=5 SV=2 CANONICAL=A6NL99-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A6NL99-1",
            "url": "",
            "sequence": {
                "sequence": "MVQASGHRRSTRGSKMVSWSVIAKIQEICERKMAREFLAEFMSTYVMMVFGLGSVAHMLLNKTFGSYLGVNLGFGFGVTMGVHMAGRTSGAHMNAAVSLTNCALGRVPWRKFPVYVLGQFLGSFLAAATIYSLFYTAILHFSGGELMVTGPVATVGIFATYLPDHMTLWRGFLNEEWLTGMLQLCLFAIVDQENNPALPGTHALVIGILVVIIRVYHGMNTGYAINPSRDLPPRIFTFIAGWGKLVFSDGENLWWVPVVAPLLGASLGGIIYLVFIGSTIPREPLKLEDSVAYEDHGITVLPKMGSHEPMISPLTLISVSPANRSSVHPAPPLHESMALEHF",
                "length": 342,
                "header": "sp|A6NL99-1|AQP73_HUMAN Isoform 1 of Putative aquaporin-7-like protein 3  OS=Homo sapiens OX=9606 GN=AQP7P3 PE=5 SV=2 CANONICAL=A6NL99-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [
        {
            "glytoucan_ac": "G49108TO",
            "type": "O-linked",
            "subtype": "O-GlcNAcylation",
            "site_category": "reported_with_glycan",
            "site_seq": "",
            "relation": "attached",
            "comment": "O-GlcNAcylation",
            "evidence": [
                {
                    "id": "A6NL99",
                    "database": "O-GlcNAc Database",
                    "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A6NL99"
                },
                {
                    "id": "37217939",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/37217939"
                }
            ]
        }
    ],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "glycoprotein",
        "glycoprotein_reported_with_glycan"
    ],
    "publication": [
        {
            "title": "Extracellular arginine availability modulates eIF2\u03b1 O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis.",
            "journal": "Journal of biomedical science",
            "date": "2023-05-22",
            "authors": "Hung Yu-Wen, Ouyang Ching, Ping Xiaoli, Qi Yue, Wang Yi-Chang, Kung Hsing-Jien, Ann David K",
            "evidence": [
                {
                    "database": "O-GlcNAc Database",
                    "id": "A6NL99",
                    "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A6NL99"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "37217939",
                    "url": "https://glygen.org/publication/PubMed/37217939"
                }
            ]
        }
    ],
    "pathway": [],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A6NL99",
                                "url": "https://www.uniprot.org/uniprot/A6NL99"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "basolateral plasma membrane",
                        "id": "GO:0016323",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A6NL99",
                                "url": "https://www.uniprot.org/uniprot/A6NL99"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 2,
                "go_terms": [
                    {
                        "name": "water transport",
                        "id": "GO:0006833",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006833",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A6NL99",
                                "url": "https://www.uniprot.org/uniprot/A6NL99"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "glycerol transmembrane transport",
                        "id": "GO:0015793",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015793",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A6NL99",
                                "url": "https://www.uniprot.org/uniprot/A6NL99"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "water channel activity",
                        "id": "GO:0015250",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015250",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A6NL99",
                                "url": "https://www.uniprot.org/uniprot/A6NL99"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "glycerol channel activity",
                        "id": "GO:0015254",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015254",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A6NL99",
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