{ "uniprot_canonical_ac": "A6NKK0-1", "uniprot_ac": "A6NKK0", "uniprot_id": "OR5H1_HUMAN", "mass": { "chemical_mass": 35387.0, "monoisotopic_mass": 35387.0 }, "refseq": { "ac": "NP_001005338", "name": "olfactory receptor 5H1", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005338" }, "gene_names": [ { "name": "OR5H1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A6NKK0", "id": "A6NKK0" }, { "name": "HSHTPCRX14; HTPCRX14", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005338", "id": "NP_001005338" }, { "name": "OR5H1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005338", "id": "NP_001005338" } ], "protein_names": [ { "name": "Olfactory receptor 5H1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "A6NKK0" }, { "name": "HTPCRX14", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A6NKK0" }, { "name": "olfactory receptor 5H1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005338", "id": "NP_001005338" } ], "function": [ { "annotation": "Odorant receptor.", "evidence": [ { "database": "UniProtKB", "id": "A6NKK0", "url": "https://www.uniprot.org/uniprot/A6NKK0#function" } ] }, { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001005338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005338" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs1340942620", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1340942620" }, { "id": "rs1340942620", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1340942620#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 146, "end_pos": 146, "sequence_org": "I", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (ILS->NLS).", "chr_id": "3", "chr_pos": "98133134", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I146", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs762519392", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs762519392" }, { "id": "rs762519392", "database": "ExAC", 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"http://gnomad.broadinstitute.org/awesome?query=rs756048849" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 228, "end_pos": 228, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KKS->NKS).", "chr_id": "3", "chr_pos": "98133381", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K228", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs769179448", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs769179448" }, { "id": "rs769179448", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs769179448" }, { "id": "rs769179448", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs769179448" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 289, "end_pos": 289, "sequence_org": "I", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (IYS->NYS).", "chr_id": "3", "chr_pos": "98133563", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I289", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs764171470", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs764171470" }, { "id": "rs764171470", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs764171470" }, { "id": "rs764171470", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs764171470" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 7, "end_pos": 7, "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NAT->NAI).", "chr_id": "3", "chr_pos": "98132717", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T7", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], 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}, { "id": "8346", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=8346", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "A6NKK0", "url": "https://www.ebi.ac.uk/intact/interactors/id:A6NKK0*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:26341", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:26341", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NX_A6NKK0", "url": "https://www.nextprot.org/entry/NX_A6NKK0", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "TYRLCTW", "url": "https://omabrowser.org/oma/group/TYRLCTW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5401587at2759", "url": "http://www.orthodb.org/?query=5401587at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48018:SF194", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018:SF194", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "http://pfam.xfam.org/family/PF13853", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "A6NKK0", "url": "https://pharos.nih.gov/targets/A6NKK0", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_A6NKK0", "url": "http://purl.obolibrary.org/obo/PR_A6NKK0", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-9752946", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9752946", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001005338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005338", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A6NKK0", "url": "https://www.uniprot.org/uniprot/A6NKK0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A6NKK0-1", "url": "https://www.uniprot.org/uniprot/A6NKK0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEENATLLTEFVLTGFLYQPQWKIPLFLAFLVIYLITIMGNLGLIAVIWKDPHLHIPMYLLLGNLAFVDAWISSTVTPKMLNNFLAKSKMISLSECKIQFFSFAISVTTECFLLATMAYDRYVAICKPLLYPAIMTNGLCIRLLILSYVGGILHALIHEGFLFRLTFCNSNIVHHIYCDTIPLSKISCTDSSINFLMVFIFSGSIQVFSIVTILVSYTFVLFAILKKKSDKGVRKAFSTCGAHLFSVSLYYGPLLFIYVGPASPQADDQDMVEPLFYTVIIPLLNPIIYSLRNKQVTVSFTKMLKKHVKVSY", "length": 313, "header": "sp|A6NKK0-1|OR5H1_HUMAN Isoform 1 of Olfactory receptor 5H1 OS=Homo sapiens OX=9606 GN=OR5H1 PE=1 SV=1 CANONICAL=A6NKK0-1" }, "isoforms": [ { "isoform_ac": "A6NKK0-1", "url": "", "sequence": { "sequence": "MEEENATLLTEFVLTGFLYQPQWKIPLFLAFLVIYLITIMGNLGLIAVIWKDPHLHIPMYLLLGNLAFVDAWISSTVTPKMLNNFLAKSKMISLSECKIQFFSFAISVTTECFLLATMAYDRYVAICKPLLYPAIMTNGLCIRLLILSYVGGILHALIHEGFLFRLTFCNSNIVHHIYCDTIPLSKISCTDSSINFLMVFIFSGSIQVFSIVTILVSYTFVLFAILKKKSDKGVRKAFSTCGAHLFSVSLYYGPLLFIYVGPASPQADDQDMVEPLFYTVIIPLLNPIIYSLRNKQVTVSFTKMLKKHVKVSY", "length": 313, "header": "sp|A6NKK0-1|OR5H1_HUMAN Isoform 1 of Olfactory receptor 5H1 OS=Homo sapiens OX=9606 GN=OR5H1 PE=1 SV=1 CANONICAL=A6NKK0-1" }, "locus": { "chromosome": "3", "start_pos": 98133636, "end_pos": 98132698, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000641874.1", "url": "https://www.ensembl.org/id/ENST00000641874.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000492953.1", "url": "https://www.ensembl.org/id/ENSP00000492953.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 5, "start_aa": "Asn", "end_pos": 5, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn5", "evidence": [ { "id": "A6NKK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NKK0#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Expression of members of the putative olfactory receptor gene family in mammalian germ cells.", "journal": "Nature", "date": "1992", "authors": "Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, G\u00e9rard C, Perret J", "evidence": [ { "database": "UniProtKB", "id": "A6NKK0", "url": "https://www.uniprot.org/uniprot/A6NKK0" } ], "reference": [ { "type": "PubMed", "id": "1370859", "url": "https://glygen.org/publication/PubMed/1370859" } ] }, { "title": "Profiling of olfactory receptor gene expression in whole human olfactory mucosa.", "journal": "PloS one", "date": "2014", "authors": "Verbeurgt C, Wilkin F, Tarabichi M, Gregoire F, Dumont JE, Chatelain P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9752946", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9752946" } ], "reference": [ { "type": "PubMed", "id": "24800820", "url": "https://glygen.org/publication/PubMed/24800820" } ] }, { "title": "The human olfactory transcriptome.", "journal": "BMC genomics", "date": "2016", "authors": "Olender T, Keydar I, Pinto JM, Tatarskyy P, Alkelai A, Chien MS, Fishilevich S, Restrepo D, Matsunami H, Gilad Y, Lancet D", "evidence": [ { "database": "Reactome", "id": "R-HSA-9752946", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9752946" } ], "reference": [ { "type": "PubMed", "id": "27515280", "url": "https://glygen.org/publication/PubMed/27515280" } ] }, { "title": "Structural instability and divergence from conserved residues underlie intracellular retention of mammalian odorant receptors.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2020", "authors": "Ikegami K, de March CA, Nagai MH, Ghosh S, Do M, Sharma R, Bruguera ES, Lu YE, Fukutani Y, Vaidehi N, Yohda M, Matsunami H", "evidence": [ { "database": "Reactome", "id": "R-HSA-9752946", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9752946" } ], "reference": [ { "type": "PubMed", "id": "31974307", "url": "https://glygen.org/publication/PubMed/31974307" } ] }, { "title": "Single-cell analysis of olfactory neurogenesis and differentiation in adult humans.", "journal": "Nature neuroscience", "date": "2020", "authors": "Durante MA, Kurtenbach S, Sargi ZB, Harbour JW, Choi R, Kurtenbach S, Goss GM, Matsunami H, Goldstein BJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9752946", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9752946" } ], "reference": [ { "type": "PubMed", "id": "32066986", "url": "https://glygen.org/publication/PubMed/32066986" } ] } ], "pathway": [ { "id": "hsa:26341", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:26341", "resource": "KEGG Pathway" }, { "id": "R-HSA-9752946", "name": "Expression and translocation of olfactory receptors", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9752946", "resource": "Reactome", "description": "Expression and translocation of olfactory receptors" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZV24-1", "protein_name": "Olfactory receptor", "gene_name": "Or5h18", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATSSEQHMERENTTLLTEFVLTGLTDHQGLQVPLFLLFLAIYLITIVGNLGLIALIWTDPHLHIPMYFFLGSLAFVDAWISSTVTPNMLFDLLSTNKMISLSECMIQFFAFAFGGTTECFLLGTMAYDRYVAICKPLLYPVIMTNRLCIRLLVSVFVGGFLHSLFHVLFLFRLTFCNSNIIHHFYCDIIPLYNISCTDPTLNLLLVFILSGSIQVVTIMTVLVSYTLVLFTILKMKSLQGIRKAFSTCGAHLLSVSLYYGPLLFMYVLPASQQTDEQGMMDSLFYTVIIPVLNPIIYSLRNKQVTDSLKKRLERHI", "length": 317 }, "evidence": [ { "id": "45935502", "url": "http://www.informatics.jax.org/homology/45935502", "database": "MGI" }, { "id": "45935501", "url": "http://www.informatics.jax.org/homology/45935501", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6GK90-1", "protein_name": "Olfactory receptor", "gene_name": "Or5h17b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSHVQCFKLGRRDATLNGTYHTGSGITGGGHLYYLNQVSVEESTFNEALNDSMEKKNETLWSEFILTGLTCQPQWKTPLFLMFLVIYLMTIVGNLGLITLIWNDPHLHIPMYLFLSNLAFVDTWLSSTVTPKMLFNLLDKGKVISIAECMTQFFSFAISVTTECFLLAAMAYDRYAAICNPLLYPVVMTNRLCIRLLALSFLGGFLHAVIHESFLSRLTFCNSNILYHFYCDVIPLLKISCTDPSLNYLMIFIFSGSIQVFTIMIVLMSYTFVLFTILKKKSDKGVRKALSTCGAHLLSVSLYYGPLLFMYVLPASSEVDAQDMILSLFYTVIVPVLNPMIYSLRNKQVIDSLKKMLKIMG", "length": 361 }, "evidence": [ { "id": "45935502", "url": "http://www.informatics.jax.org/homology/45935502", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6GLG4-1", "protein_name": "Olfactory receptor", "gene_name": "Or5h26", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGIENATLLTEFVLTGLSHLPQWKIPLFLLFLVIYLITIVGNLGLITLIWNDPHLHIPMYLFLGSLAFVDTWLSSTVTPKMLLDFFTKSKLISFSECMIQFFSFGISATTECFLLAAMAYDRYVAICKPLLYPVIMTNRLCVRLLTMSFIGGFIHVLIHEGFLFRITFCDSNVIHHFYCDIMPLLKISCSDPSLNYLMLFILSGSIQVFSILTILISYTLVLFSILKQKSIKGIKKSFSTCGAHLLSVSLYYGSLLFMYVRPASPQVDDQDMMDSVFYTVIIPVLNPIIYSLRNKQVKNSLEKLLKRNT", "length": 309 }, "evidence": [ { "id": "45935500", "url": "http://www.informatics.jax.org/homology/45935500", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6GM71-1", "protein_name": "Olfactory receptor", "gene_name": "ENSRNOG00000063020", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGTSTEDIGMENTTLLIQFVLTGLVHLPQWKIPLFLLFLVIYLITIVGNLGLITLIWNDPHLHIPMYLFLGSLAFVDTWLSSTVTPKMLQDIFAKSKLISFSGCMTQCFSFVMSATTECFLLAVMAYDRYVAICKPLLYPVIMTNRLCVHFLTLSLVGGFIHALIHEGFLFKLIFRNSNIIYHFYCDIIPLLKISCNDPSLNYLMLFIFSGSIQVFTITTILVSYTLVLFSILKQKSIKSIKKAFSTCGAHLLSVSLYYGPLLFMYVRPAPPQVDDQDMMDSVFYTIIIPVLNPIVYSLRNKQVKKSLAKFLKRNT", "length": 316 }, "evidence": [ { "id": "A6NKK0", "url": "https://omabrowser.org/oma/group/A6NKK0/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "A6NDH6-1", "protein_name": "Olfactory receptor 5H15", "gene_name": "OR5H15", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEEENATLLTEFVLTGFLYQPQWKIPLFLAFLVIYLITIMGNLGLIAVIWKDPHLHIPMYLLLGNLAFVDAWISSTVTPKMLNNFLAKSKMISLSECKIQFFSIAIGVTTECFLLATMAYDRYVAICKPLLYPAIMTNGLCIRLLILSYIAGILHALIHEGFLFRLTFCNSNIVHHIYCDTIPLSKISCTDSSINFLMVFIFSGSIQVFSIVTILISYTFVLFTVLEKKSDKGVRKAFSTCGAHLFSVCLYYGPLLLMYVGPASPQADGQNMVEPLFYTVIIPLLNPIIYSLRNKQVIVSFIKMLKRNVKVSY", "length": 313 }, "evidence": [ { "id": "45935502", "url": "http://www.informatics.jax.org/homology/45935502", "database": "MGI" }, { "id": "45935501", "url": "http://www.informatics.jax.org/homology/45935501", "database": "MGI" }, { "id": "45935500", "url": "http://www.informatics.jax.org/homology/45935500", "database": "MGI" }, { "id": "45935499", "url": "http://www.informatics.jax.org/homology/45935499", "database": "MGI" }, { "id": "45935498", "url": "http://www.informatics.jax.org/homology/45935498", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "A6NHG9-1", "protein_name": "Olfactory receptor 5H14", "gene_name": "OR5H14", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEEENATLLTEFVLTGFLYQPQWKIPLFLAFLVIYLITIMGNLGLIAVIWKDPHLHIPMYLLLGNLAFVDALLSSSVTLKMLINFLAKSKMISLSECKIQLFSFAISVTTECFLLATMAYDRYVAICKPLLYPAIMTNGLCIRLLILSYVGGLLHALIHEGFLFRLTFCNSNIIQHFYCDIIPLLKISYTDSSINFLMVFIFAGSIQVFTIGTVLISYIFVLYTILKKKSVKGMRKAFSTCGAHLLSVSLYYGPLAFMYMGSASPQADDQDMMESLFYTVIVPLLNPMIYSLRNKQVIASFTKMFKRNDV", "length": 310 }, "evidence": [ { "id": "45935502", "url": "http://www.informatics.jax.org/homology/45935502", "database": "MGI" }, { "id": "45935501", "url": "http://www.informatics.jax.org/homology/45935501", "database": "MGI" }, { "id": "45935499", "url": "http://www.informatics.jax.org/homology/45935499", "database": "MGI" }, { "id": "45935498", "url": "http://www.informatics.jax.org/homology/45935498", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "E9PYP4-1", "protein_name": "Olfactory receptor", "gene_name": "Or5h26", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGIENTTLLTEFVLTGLSHLPQWKIPLFLLFLVIYLITIVGNLGLITLIWNDPHLHIPMYLFLGSLAFVDTWLSSTVTPKMLLDFFSKSKLISFSECMIQFFSFGISATTECFLLAAMAYDRYVAICKPLLYPVIMTNRLCVLLLTLSFVGGFIHVLIHESFLFRLTFCNSNIIHHFYCDVMPLLKISCNDPSLNYLMLFIFSGSIQVFSILTILISYTLVLFSILKQKSIKSIKKAFSTCGAHLLSVSLYYGSLLFMYVRPASPQVDDQDMMDSIFYTVIIPVLNPIIYSLRNKQVKNSLEKFLKRNT", "length": 309 }, "evidence": [ { "id": "45935500", "url": "http://www.informatics.jax.org/homology/45935500", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N5T5-1", "protein_name": "Olfactory receptor", "gene_name": "Or5h22", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKNSTVLTEFVLTGLTESPELQVPLFLFFLVIYLITIVGNLGLIALIWNDPHLHIPMYFFLGHLAFVDASLSSTVAPKMLLDFLQMNKMISYSECMTQFFIFAICATTECFLLGAMAYDRYVAICKPLLYPMIMTKRLCICLLVLSFVGGILHSSIHEGFLLLLNFCNSNIVHHFFCDIVPLLKISCTDTTLNFQLIFVLAGIIQVLTVVIVLVSYTLVLLTILQRKSVQSMKKAFSTCGAHLLSVSLYYGPLLIMYIFPVSQEADGQDIIDSLFYTVIIPVLNPIIYSLRNKQVMDSLKKVLKKKA", "length": 307 }, "evidence": [ { "id": "45935502", "url": "http://www.informatics.jax.org/homology/45935502", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N1Z8-1", "protein_name": "Olfactory receptor", "gene_name": "Or5h23", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METDNTTLLIQFVLSGLVHLPQWKIPLFLLFLVIYLITIVGNLGLIILIWNDPHLHIPMYLFLGCLAFVDTWLSSTVTPKMLQDIFSKSKLISFSECMIQFFSFVVSATTECFLLAAMAYDRYVAICKPLLYPVIMTNRLCVSLLTLSFLGGFIHALIHEGFLFRLIFCRSHIINHFYCDVMPLLKISCNDPSINYLMLFIFSGSIQVFTITTILVSYTLVLFSILKKKSLKSIKKAFSTCGAHLLSVSLYYGPLLFMYVRPASPQVNDEDMMDSVFYTIIIPVLNPIIYSLRNEQVKKSLAKCLRRNT", "length": 309 }, "evidence": [ { "id": "45935498", "url": "http://www.informatics.jax.org/homology/45935498", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7TS43-1", "protein_name": "Olfactory receptor", "gene_name": "Or5h25", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEMDNTTLLIQFVLSGLVHLPQWKIPLFLLFLVIYLITIVGNLGLITLIWNDPHLHIPMYFFLGSLAFVDTWLSSTVTPKMLQDIFAKNKMISFSECMIQFFSFGISATTECFLLASMAYDRYVAICKPLLYPVIMTNRLCVRLLTLSFVGGFIHALIHEGFLFRLIFCSSHIIDHFYCDVMPLLKISCNDPSINYLMLFIFSGSIQVFTITTILVSYTLVLFSILKQKSLKSIKKAFSTCGAHLLSVSLYYGPLLFMYVRPASPQVNDEDMMDSVFYTIIIPVLNPIIYSLRNKQVKKSLAKFLRRNT", "length": 309 }, "evidence": [ { "id": "45935499", "url": "http://www.informatics.jax.org/homology/45935499", "database": "MGI" }, { "id": "A6NKK0", "url": "https://omabrowser.org/oma/group/A6NKK0/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NGV6-1", "protein_name": "Olfactory receptor 5H6", "gene_name": "OR5H6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFLYLCFIFQRTCSEEMEEENATLLTEFVLTGFLHQPDCKIPLFLAFLVIYLITIMGNLGLIVLIWKDPHLHIPMYLFLGSLAFVDASLSSTVTPKMLINFLAKSKMISLSECMVQFFSLVTTVTTECFLLATMAYDRYVAICKALLYPVIMTNELCIQLLVLSFIGGLLHALIHEAFSFRLTFCNSNIIQHFYCDIIPLLKISCTDSSINFLMVFIFAGSVQVFTIGTILISYTIILFTILEKKSIKGIRKAVSTCGAHLLSVSLYYGPLTFKYLGSASPQADDQDMMESLFYTVIVPLLNPMIYSLRNKQVIASFTKMFKSNV", "length": 325 }, "evidence": [ { "id": "45935502", "url": "http://www.informatics.jax.org/homology/45935502", "database": "MGI" }, { "id": "45935501", "url": "http://www.informatics.jax.org/homology/45935501", "database": "MGI" }, { "id": "45935500", "url": "http://www.informatics.jax.org/homology/45935500", "database": "MGI" }, { "id": "45935499", "url": "http://www.informatics.jax.org/homology/45935499", "database": "MGI" }, { "id": "45935498", "url": "http://www.informatics.jax.org/homology/45935498", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q8NGV7-1", "protein_name": "Olfactory receptor 5H2", "gene_name": "OR5H2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEQDNTTLLTEFVLTGLTYQPEWKMPLFLVFLVIYLITIVWNLGLIALIWNDPQLHIPMYFFLGSLAFVDAWISSTVTPKMLVNFLAKNRMISLSECMIQFFSFAFGGTTECFLLATMAYDRYVAICKPLLYPVIMNNSLCIRLLAFSFLGGFLHALIHEVLIFRLTFCNSNIIHHFYCDIIPLFMISCTDPSINFLMVFILSGSIQVFTIVTVLNSYTFALFTILKKKSVRGVRKAFSTCGAHLLSVSLYYGPLIFMYLRPASPQADDQDMIDSVFYTIIIPLLNPIIYSLRNKQVIDSFTKMVKRNV", "length": 309 }, "evidence": [ { "id": "45935502", "url": "http://www.informatics.jax.org/homology/45935502", "database": "MGI" }, { "id": "45935501", "url": "http://www.informatics.jax.org/homology/45935501", "database": "MGI" }, { "id": "45935500", "url": "http://www.informatics.jax.org/homology/45935500", "database": "MGI" }, { "id": "45935498", "url": "http://www.informatics.jax.org/homology/45935498", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VEX5-1", "protein_name": "Olfactory receptor 5H18", "gene_name": "Or5h18", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEDGNTTLLTEFVLTGLTDHQGLQVPLFLLFLMIYLITVVGNLGLIALIWSDPHLHIPMYLFLGSLAFVDAWISSAVTPNMLFDLLSKNKMISLSECMIQFFAFAFGGTTECFLLGTMAYDRYVAICKPLLYPVIMTNRLCIRLLVSVFIGGFLHSLFHVLFLLRLTFCNSNIIHHFYCDIIPLYNISCTDPTLNLLLVFILSGSIQVFTIMTVLVSYTLVLFTILKMKSLQGIRKAFSTCGAHLLSVSLYYGPLLFMYVLPASQQTDGQGMMDSLFYTVIIPVLNPIIYSLRNKQVTDSLKKRLERHV", "length": 309 }, "evidence": [ { "id": "45935501", "url": "http://www.informatics.jax.org/homology/45935501", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A6NKK0", "url": "https://www.uniprot.org/uniprot/A6NKK0" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A6NKK0", "url": "https://www.uniprot.org/uniprot/A6NKK0" } ], "pmid": "" }, { "name": "odorant binding", "id": "GO:0005549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005549", "evidence": [ { "database": "UniProtKB", "id": "A6NKK0", "url": "https://www.uniprot.org/uniprot/A6NKK0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A6NKK0", "url": "https://www.uniprot.org/uniprot/A6NKK0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 5 ], "o_linked_sites": [], "snv_sites": [ 7, 146, 172, 228, 289 ], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 5 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }