The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "R-SSC-3322001", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-3322001" } ] }, { "id": "R-SSC-3322003", "name": "Autoglucosylation of GYG1 complexed with GYS1-b", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "R-SSC-3322003", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-3322003" } ] }, { "id": "R-SSC-3322005", "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "R-SSC-3322005", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-3322005" } ] }, { "id": "R-SSC-3322025", "name": "Autoglucosylation of GYG1 complexed with GYS1-a", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "R-SSC-3322025", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-3322025" } ] }, { "id": "R-SSC-3322041", "name": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "R-SSC-3322041", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-3322041" } ] }, { "id": "R-SSC-3322057", "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "R-SSC-3322057", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-3322057" } ] }, { "id": "R-SSC-3781018", "name": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "R-SSC-3781018", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-3781018" } ] }, { "id": "R-SSC-3781023", "name": "PPP1R3C binds to glycogen:GYG1:GYS1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "R-SSC-3781023", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-3781023" } ] }, { "id": "R-SSC-3781024", "name": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "R-SSC-3781024", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-3781024" } ] }, { "id": "R-SSC-6798748", "name": "Exocytosis of secretory granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, secretory granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "R-SSC-6798748", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-6798748" } ] }, { "id": "R-SSC-6800434", "name": "Exocytosis of ficolin-rich granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, ficolin-1-rich granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "R-SSC-6800434", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-6800434" } ] }, { "id": "R-SSC-71552", "name": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "R-SSC-71552", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-71552" } ] }, { "id": "R-SSC-71593", "name": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "R-SSC-71593", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-71593" } ] }, { "id": "R-SSC-9036727", "name": "GAA hydrolyzes lysosomal glycogen", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal lumen", "input_participant_list": [], "output_participant_list": [ "R-ALL-1605745" ], "enzyme_list": [], "evidence": [ { "id": "R-SSC-9036727", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-SSC-9036727" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1605745", "participant_name": "Glc [lysosomal lumen]", "crossref": [ { "id": "C00267", "database": "COMPOUND", "url": "" }, { "id": "17925", "database": "ChEBI", "url": "" }, { "id": "G58161NS", "database": "GlyTouCan", "url": "" }, { "id": "000003861213", "database": "ZINC", "url": "" }, { "id": "HMDB0003345", "database": "HMDB Metabolite", "url": "" }, { "id": "8143952", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0003345", "database": "HMDB Metabolite", "url": "" }, { "id": "17925", "database": "ChEBI", "url": "" }, { "id": "G58161NS", "database": "GlyTouCan", "url": "" }, { "id": "C00267", "database": "COMPOUND", "url": "" }, { "id": "8143952", "database": "PubChem Substance", "url": "" }, { "id": "000003861213", "database": "ZINC", "url": "" }, { "id": "C00267", "database": "COMPOUND", "url": "" }, { "id": "17925", "database": "ChEBI", "url": "" }, { "id": "G58161NS", "database": "GlyTouCan", "url": "" }, { "id": "000003861213", "database": "ZINC", "url": "" }, { "id": "HMDB0003345", "database": "HMDB Metabolite", "url": "" }, { "id": "8143952", "database": "PubChem Substance", "url": "" }, { "id": "C00267", "database": "COMPOUND", "url": "" }, { "id": "000003861213", "database": "ZINC", "url": "" }, { "id": "8143952", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0003345", "database": "HMDB Metabolite", "url": "" }, { "id": "17925", "database": "ChEBI", "url": "" }, { "id": "G58161NS", "database": "GlyTouCan", "url": "" }, { "id": "C00267", "database": "COMPOUND", "url": "" }, { "id": "17925", "database": "ChEBI", "url": "" }, { "id": "G58161NS", "database": "GlyTouCan", "url": "" }, { "id": "000003861213", "database": "ZINC", "url": "" }, { "id": "HMDB0003345", "database": "HMDB Metabolite", "url": "" }, { "id": "8143952", "database": "PubChem Substance", "url": "" }, { "id": "C00267", "database": "COMPOUND", "url": "" }, { "id": "17925", "database": "ChEBI", "url": "" }, { "id": "G58161NS", "database": "GlyTouCan", "url": "" }, { "id": "000003861213", "database": "ZINC", "url": "" }, { "id": "HMDB0003345", "database": "HMDB Metabolite", "url": "" }, { "id": "8143952", "database": "PubChem Substance", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A0B4LFW5", "gene_name": "Gyg", "activity": [ { "ec_number": "2.4.1.186", "activity": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP.", "evidence": [ { "id": "A0A0B4LFW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4LFW5" } ] }, { "ec_number": "2.4.1.186", "activity": "", "evidence": [ { "id": "A0A0B4LFW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4LFW5" } ] } ] }, { "uniprot_ac": "O08730", "gene_name": "Gyg1", "activity": [ { "ec_number": "2.4.1.186", "activity": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP.", "evidence": [ { "id": "O08730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08730" } ] }, { "ec_number": "2.4.1.186", "activity": "", "evidence": [ { "id": "O08730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08730" } ] } ] }, { "uniprot_ac": "O15488", "gene_name": "GYG2", "activity": [ { "ec_number": "2.4.1.186", "activity": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP.", "evidence": [ { "id": "O15488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15488" } ] }, { "ec_number": "2.4.1.186", "activity": "", "evidence": [ { "id": "O15488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15488" } ] } ] }, { "uniprot_ac": "P36143", "gene_name": "GLG1", "activity": [ { "ec_number": "2.4.1.186", "activity": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP.", "evidence": [ { "id": "P36143", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36143" } ] }, { "ec_number": "2.4.1.186", "activity": "", "evidence": [ { "id": "P36143", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36143" } ] } ] }, { "uniprot_ac": "P46976", "gene_name": "GYG1", "activity": [ { "ec_number": "2.4.1.186", "activity": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP.", "evidence": [ { "id": "P46976", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46976" } ] }, { "ec_number": "2.4.1.186", "activity": "", "evidence": [ { "id": "P46976", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46976" } ] } ] }, { "uniprot_ac": "P47011", "gene_name": "GLG2", "activity": [ { "ec_number": "2.4.1.186", "activity": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP.", "evidence": [ { "id": "P47011", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47011" } ] }, { "ec_number": "2.4.1.186", "activity": "", "evidence": [ { "id": "P47011", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47011" } ] } ] }, { "uniprot_ac": "Q9R062", "gene_name": "Gyg1", "activity": [ { "ec_number": "2.4.1.186", "activity": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP.", "evidence": [ { "id": "Q9R062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9R062" } ] }, { "ec_number": "2.4.1.186", "activity": "", "evidence": [ { "id": "Q9R062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9R062" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 188, "end_pos": 190 }, { "start_pos": 221, "end_pos": 223 }, { "start_pos": 278, "end_pos": 280 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }