{ "uniprot_canonical_ac": "A0A0G2KAI3-1", "uniprot_ac": "A0A0G2KAI3", "uniprot_id": "A0A0G2KAI3_RAT", "mass": { "chemical_mass": 54599.0, "monoisotopic_mass": 54599.0 }, "refseq": {}, "gene_names": [ { "name": "Cyp2w1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3", "id": "A0A0G2KAI3" } ], "protein_names": [ { "name": "Cytochrome P450, family 2, subfamily w, polypeptide 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "A0A0G2KAI3" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAI3", "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3" } ], "common_name": "Rat" } ], "gene": [ { "name": "Cyp2w1", "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3", "locus": { "chromosome": "12", "start_pos": 15291704, "end_pos": 15296421, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000051770", "url": "https://www.ensembl.org/id/ENSRNOG00000051770" } ] } } ], "crossref": [ { "id": "ENSRNOG00000051770", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000051770", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002401", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002401", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036396", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036396", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "TSGRPTM", "url": "https://omabrowser.org/oma/group/TSGRPTM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR24300", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24300", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24300:SF291", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24300:SF291", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00067", "url": "http://pfam.xfam.org/family/PF00067", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-211958", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-211958", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-211981", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-211981", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "1305193", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1305193", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2KAI3", "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2KAI3-1", "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELLVLCVWGILLLLGLWGLLRGCAQDPSMTRQWPPGPRPLPFLGNLHLLGVTHQDRALMELSERYGPMFTIHLGSQKTVVLSGYEVVREALVGTGHELADRPPIPIFQLIQRGGGIFFSSGVHWKVARQFTVRTLQSLGIRQPPMVGKVLQELVCLKGQLDSYGGQPFPLTLLGWAPCNITFTLLFGQRFDYQDPVFVSLLSLIDQVMVLLGSPGIQLFNTFPRLGALLRLHRPVLSKIEEVRTILRTLLEAQRPPLPNGSPARSYVEALLQQGQDDPEDMFSEANVLACTLDMVMAGTETTAATLQWAVFLMVKHPHVQGRVQEELDRVLGPGQLPQPEDQRALPYTSAVLHEVQRYITLLPHVPRCTAADIQLGGYLLPKGTPVIPLLTSVLLDKTQWETPSQFNPNHFLDAKGCFMKRGAFLPFSTGRRVCVGESLARTELFLLFAGLLQQYHLLPPPGLSPADLDLRPAPAFTMRPPAQTLRVVPRS", "length": 492, "header": "tr|A0A0G2KAI3-1|A0A0G2KAI3_RAT Isoform 1 of Cytochrome P450, family 2, subfamily w, polypeptide 1 OS=Rattus norvegicus OX=10116 GN=Cyp2w1 PE=3 SV=2 CANONICAL=A0A0G2KAI3-1" }, "isoforms": [ { "isoform_ac": "A0A0G2KAI3-1", "url": "", "sequence": { "sequence": "MELLVLCVWGILLLLGLWGLLRGCAQDPSMTRQWPPGPRPLPFLGNLHLLGVTHQDRALMELSERYGPMFTIHLGSQKTVVLSGYEVVREALVGTGHELADRPPIPIFQLIQRGGGIFFSSGVHWKVARQFTVRTLQSLGIRQPPMVGKVLQELVCLKGQLDSYGGQPFPLTLLGWAPCNITFTLLFGQRFDYQDPVFVSLLSLIDQVMVLLGSPGIQLFNTFPRLGALLRLHRPVLSKIEEVRTILRTLLEAQRPPLPNGSPARSYVEALLQQGQDDPEDMFSEANVLACTLDMVMAGTETTAATLQWAVFLMVKHPHVQGRVQEELDRVLGPGQLPQPEDQRALPYTSAVLHEVQRYITLLPHVPRCTAADIQLGGYLLPKGTPVIPLLTSVLLDKTQWETPSQFNPNHFLDAKGCFMKRGAFLPFSTGRRVCVGESLARTELFLLFAGLLQQYHLLPPPGLSPADLDLRPAPAFTMRPPAQTLRVVPRS", "length": 492, "header": "tr|A0A0G2KAI3-1|A0A0G2KAI3_RAT Isoform 1 of Cytochrome P450, family 2, subfamily w, polypeptide 1 OS=Rattus norvegicus OX=10116 GN=Cyp2w1 PE=3 SV=2 CANONICAL=A0A0G2KAI3-1" }, "locus": { "chromosome": "12", "start_pos": 15296421, "end_pos": 15291707, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000091003.2", "url": "https://www.ensembl.org/id/ENSRNOT00000091003.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000075407.2", "url": "https://www.ensembl.org/id/ENSRNOP00000075407.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-RNO-211958", "name": "Miscellaneous substrates", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-211958", "resource": "Reactome", "description": "Miscellaneous substrates" }, { "id": "R-RNO-211981", "name": "Xenobiotics", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-211981", "resource": "Reactome", "description": "Xenobiotics" } ], "orthologs": [ { "uniprot_canonical_ac": "E9Q816-1", "protein_name": "Cytochrome P450 2W1", "gene_name": "Cyp2w1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALLLLGVWGILLLLGLWGLLQGCTRSPSLAPRWPPGPRPLPFLGNLHLLGVTQQDRALMELSERYGPMFTIHLGSQKTVVLSGYEVVREALVGTGHELADRPPIPIFQHIQRGGGIFFSSGARWRAGRQFTVRTLQSLGVQQPSMVGKVLQELACLKGQLDSYGGQPLPLALLGWAPCNITFTLLFGQRFDYQDPVFVSLLSLIDQVMVLLGSPGIQLFNTFPRLGAFLRLHRPVLSKIEEVRTILRTLLETRRPPLPTGGPAQSYVEALLQQGQEDDPEDMFGEANVLACTLDMVMAGTETTAATLQWAVFLMVKHPHVQGRVQEELDRVLGPGQLPQPEHQRALPYTSAVLHEVQRYITLLPHVPRCTAADIQLGGYLLPKGTPVIPLLTSVLLDKTQWETPSQFNPNHFLDAKGRFMKRGAFLPFSAGRRVCVGKSLARTELFLLFAGLLQRYRLLPPPGLSPADLDLRPAPAFTMRPPAQTLCVVPRS", "length": 493 }, "evidence": [ { "id": "A0A0G2KAI3", "url": "https://omabrowser.org/oma/group/A0A0G2KAI3/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8TAV3-1", "protein_name": "Cytochrome P450 2W1", "gene_name": "CYP2W1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPFPLALLGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIEEVRAILRTLLEARRPHVCPGDPVCSYVDALIQQGQGDDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLPHVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPARAFTMRPRAQALCAVPRP", "length": 490 }, "evidence": [ { "id": "A0A0G2KAI3", "url": "https://omabrowser.org/oma/group/A0A0G2KAI3/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "retinoic acid 4-hydroxylase activity", "id": "GO:0008401", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008401", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAI3", "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3" } ], "pmid": "" }, { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAI3", "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3" } ], "pmid": "" }, { "name": "all-trans retinal binding", "id": "GO:0005503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005503", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAI3", "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAI3", "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "id": "GO:0016712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016712", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAI3", "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3" } ], "pmid": "" }, { "name": "retinoic acid binding", "id": "GO:0001972", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001972", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAI3", "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3" } ], "pmid": "" }, { "name": "all-trans-retinol binding", "id": "GO:1904768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904768", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAI3", "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAI3", "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3" } ], "pmid": "" }, { "name": "endoplasmic reticulum lumen", "id": "GO:0005788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAI3", "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAI3", "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAI3", "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "xenobiotic metabolic process", "id": "GO:0006805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006805", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAI3", "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3" } ], "pmid": "" }, { "name": "phospholipid metabolic process", "id": "GO:0006644", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006644", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAI3", "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3" } ], "pmid": "" }, { "name": "organic acid metabolic process", "id": "GO:0006082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006082", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAI3", "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3" } ], "pmid": "" }, { "name": "retinoic acid catabolic process", "id": "GO:0034653", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034653", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAI3", "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3" } ], "pmid": "" }, { "name": "aflatoxin metabolic process", "id": "GO:0046222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046222", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAI3", "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3" } ], "pmid": "" } ] } ] 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