{ "bcoid": "GLY_000838", "title": "Dicty Protein Function (UniProtKB)", "description": "The Dicty Protein Function (UniProtKB) dataset contains biological function annotation for dicty [taxid:44689] ...", "filename": "dicty_protein_function_uniprotkb.csv", "filetype": "csv", "categories": { "species": [ "Dictyostelium discoideum" ], "molecule": [ "Protein" ], "tag": [ "Protein Function" ], "file_type": [ "csv" ], "status": [ "Reviewed" ], "scope": [ "internal" ] }, "minitable": { "content": [ [ "Q54D00-1...", "protein_xref..." ], [ "Q54D04-1...", "protein_xref..." ] ], "headers": [ "uniprotkb_ca...", "xref_key..." ], "colwidth": [ "40%", "20%" ] }, "sampledata": { "type": "table", "data": [ [ { "type": "string", "label": "uniprotkb_canonical_ac" }, { "type": "string", "label": "xref_key" }, { "type": "string", "label": "xref_id" }, { "type": "string", "label": "annotation" } ], [ "Q54D00-1", "protein_xref_uniprotkb_fun", "Q54D00", "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)." ], [ "Q54D04-1", "protein_xref_uniprotkb_fun", "Q54D04", "Catalyzes the reversible oxidation of malate to oxaloacetate." ], [ "Q54IM7-1", "protein_xref_uniprotkb_fun", "Q54IM7", "Binds F-actin and nucleates actin assembly." ], [ "Q54IM7-1", "protein_xref_pubmed", "18522444", "Binds F-actin and nucleates actin assembly." ], [ "Q54D06-1", "protein_xref_uniprotkb_fun", "Q54D06", "Has no ubiquitin ligase activity on its own. The ube2v/ube2n heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity)." ], [ "Q54D07-1", "protein_xref_uniprotkb_fun", "Q54D07", "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Cytochrome c1 is a catalytic core subunit containing a c-type heme. It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c." ], [ "Q54D07-1", "protein_xref_uniprotkb_fun", "P07143", "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Cytochrome c1 is a catalytic core subunit containing a c-type heme. It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c." ], [ "Q54D08-1", "protein_xref_uniprotkb_fun", "Q54D08", "Plays a role in regulation of adenylate cyclase and protein kinase B (PKB) activation during aggregation. Involved in both chemotaxis and signal relay." ], [ "Q54D08-1", "protein_xref_pubmed", "16079174", "Plays a role in regulation of adenylate cyclase and protein kinase B (PKB) activation during aggregation. Involved in both chemotaxis and signal relay." ], [ "Q54IM8-1", "protein_xref_uniprotkb_fun", "Q54IM8", "Isobutyryl-CoA dehydrogenase which catalyzes one of the steps of the valine catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of (2S)-2-methylbutanoyl-CoA." ], [ "Q54IM8-1", "protein_xref_uniprotkb_fun", "Q9UKU7", "Isobutyryl-CoA dehydrogenase which catalyzes one of the steps of the valine catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of (2S)-2-methylbutanoyl-CoA." ], [ "Q8MQU6-1", "protein_xref_uniprotkb_fun", "Q8MQU6", "Peroxisomal protein involved in the cellular biosynthesis of citrate, and required primarily for cell growth and modulation of multicellular development." ], [ "Q8MQU6-1", "protein_xref_pubmed", "15225305", "Peroxisomal protein involved in the cellular biosynthesis of citrate, and required primarily for cell growth and modulation of multicellular development." ], [ "Q55BE5-1", "protein_xref_uniprotkb_fun", "Q55BE5", "Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin." ], [ "Q55BE5-1", "protein_xref_uniprotkb_fun", "ARBA00024677", "Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin." ], [ "Q54RX6-1", "protein_xref_uniprotkb_fun", "Q54RX6", "Involved in calcium binding and microtubule stabilization." ], [ "O60999-1", "protein_xref_uniprotkb_fun", "O60999", "Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit (By similarity). Required at several stages during development. CulA and fbxA regulate multicellular development by targeting regA for degradation via a pathway that requires erkB function, leading to an increase in cAMP and PKA activity." ], [ "O60999-1", "protein_xref_pubmed", "11390363", "Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit (By similarity). Required at several stages during development. CulA and fbxA regulate multicellular development by targeting regA for degradation via a pathway that requires erkB function, leading to an increase in cAMP and PKA activity." ], [ "Q54RX5-1", "protein_xref_uniprotkb_fun", "Q54RX5", "Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body." ], [ "Q54RX5-1", "protein_xref_uniprotkb_fun", "PIRNR011789", "Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body." ], [ "Q869L3-1", "protein_xref_uniprotkb_fun", "Q869L3", "Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus." ], [ "Q869L3-1", "protein_xref_uniprotkb_fun", "Q12019", "Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus." ], [ "Q54RX0-1", "protein_xref_uniprotkb_fun", "Q54RX0", "Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome." ], [ "Q54RX0-1", "protein_xref_uniprotkb_fun", "P62308", "Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome." ], [ "Q54RX1-1", "protein_xref_uniprotkb_fun", "Q54RX1", "Involved in calcium binding and microtubule stabilization." ], [ "Q54MM6-1", "protein_xref_uniprotkb_fun", "Q54MM6", "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules." ], [ "Q54MM6-1", "protein_xref_uniprotkb_fun", "ARBA00025362", "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules." ], [ "Q54PT2-1", "protein_xref_uniprotkb_fun", "Q54PT2", "Involved in intracellular protein transport probably out of a prevacuolar endosomal compartment. May be involved in the release of components of the bilayered coat from the endosomal membrane. The association with ESCRT-III complex mediates the ATP-dependent disassembly of the ESCRT-III complex (By similarity)." ], [ "P0C8Z5-1", "protein_xref_uniprotkb_fun", "P0C8Z5", "Chaperone protein which promotes assembly of the 20S proteasome." ], [ "Q54PT9-1", "protein_xref_uniprotkb_fun", "Q54PT9", "Transcription factor which acts as a key regulator of pstA (prestalk-A) cells differentiation. Essential for ecmA-specific gene expression." ], [ "Q54PT9-1", "protein_xref_pubmed", "22811266", "Transcription factor which acts as a key regulator of pstA (prestalk-A) cells differentiation. Essential for ecmA-specific gene expression." ], [ "Q54DW2-1", "protein_xref_uniprotkb_fun", "Q54DW2", "Possible role in transport between endoplasmic reticulum and Golgi." ], [ "Q54E35-1", "protein_xref_uniprotkb_fun", "Q54E35", "Rho GTPase-activating protein involved in the signal transduction pathway." ], [ "Q54E36-1", "protein_xref_uniprotkb_fun", "Q54E36", "Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity)." ], [ "Q54N45-1", "protein_xref_uniprotkb_fun", "Q54N45", "Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly (By similarity)." ], [ "Q54N40-1", "protein_xref_uniprotkb_fun", "Q54N40", "Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (By similarity). When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity)." ], [ "Q54N40-1", "protein_xref_uniprotkb_fun", "Q04370", "Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (By similarity). When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity)." ], [ "Q54N40-1", "protein_xref_uniprotkb_fun", "O00623", "Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (By similarity). When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity)." ], [ "Q54E33-1", "protein_xref_uniprotkb_fun", "Q54E33", "Key assembly factor specifically required for the stability of axonemal dynein heavy chains in cytoplasm." ], [ "Q54E33-1", "protein_xref_uniprotkb_fun", "A8J3F6", "Key assembly factor specifically required for the stability of axonemal dynein heavy chains in cytoplasm." ], [ "Q86AV4-1", "protein_xref_uniprotkb_fun", "Q86AV4", "May serve to lubricate the movement of the cellulose microfibrils during cell growth and wall extension and/or may serve to maintain the fluid state of the slug cell wall." ], [ "Q86AV4-1", "protein_xref_pubmed", "11891242", "May serve to lubricate the movement of the cellulose microfibrils during cell growth and wall extension and/or may serve to maintain the fluid state of the slug cell wall." ], [ "Q86AV4-1", "protein_xref_pubmed", "12832080", "May serve to lubricate the movement of the cellulose microfibrils during cell growth and wall extension and/or may serve to maintain the fluid state of the slug cell wall." ], [ "Q55ET7-1", "protein_xref_uniprotkb_fun", "Q55ET7", "Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP." ], [ "Q55ET7-1", "protein_xref_uniprotkb_fun", "MF_03167", "Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP." ], [ "Q54N48-1", "protein_xref_uniprotkb_fun", "Q54N48", "Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation." ], [ "Q54N48-1", "protein_xref_uniprotkb_fun", "MF_03035", "Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation." ], [ "Q54N49-1", "protein_xref_uniprotkb_fun", "Q54N49", "Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity)." ], [ "Q54N49-1", "protein_xref_uniprotkb_fun", "Q9NPH2", "Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity)." ], [ "P11874-1", "protein_xref_uniprotkb_fun", "P11874", "Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity)." ], [ "Q54DE8-1", "protein_xref_uniprotkb_fun", "Q54DE8", "Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Requires the other members of the gamma-secretase complex to have a protease activity (By similarity)." ], [ "Q54B49-1", "protein_xref_uniprotkb_fun", "Q54B49", "Probable polyketide synthase." ], [ "Q54JI9-1", "protein_xref_uniprotkb_fun", "Q54JI9", "Involved in autophagy. May be required to recruit the atg8-phosphatidylinositol conjugate and the atg12-atg5 conjugate to the pre-autophagosomal structure (By similarity)." ], [ "Q54JI9-1", "protein_xref_pubmed", "14736886", "Involved in autophagy. May be required to recruit the atg8-phosphatidylinositol conjugate and the atg12-atg5 conjugate to the pre-autophagosomal structure (By similarity)." ], [ "Q54PB4-1", "protein_xref_uniprotkb_fun", "Q54PB4", "May phosphorylate a specific serine in the N-terminus of a myosin light chain." ], [ "Q55E06-1", "protein_xref_uniprotkb_fun", "Q55E06", "Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity)." ], [ "Q552C6-1", "protein_xref_uniprotkb_fun", "Q552C6", "Positive regulator of gsk3/gskA activity required for cell pattern formation and a downstream effector of carC. The kinases, gsk3/gskA, zakA and zak2, form part of a signaling pathway that responds to extracellular cyclic AMP. The pathway has a role in transcriptional regulation; required to direct prespore/spore fates during development. Zak2 negatively regulates prestalk differentiation by regulating expression of ecmA. Phosphorylates Y-214 of gsk3/gskA, in vitro." ], [ "Q552C6-1", "protein_xref_pubmed", "21205787", "Positive regulator of gsk3/gskA activity required for cell pattern formation and a downstream effector of carC. The kinases, gsk3/gskA, zakA and zak2, form part of a signaling pathway that responds to extracellular cyclic AMP. The pathway has a role in transcriptional regulation; required to direct prespore/spore fates during development. Zak2 negatively regulates prestalk differentiation by regulating expression of ecmA. Phosphorylates Y-214 of gsk3/gskA, in vitro." ], [ "Q550F6-1", "protein_xref_uniprotkb_fun", "Q550F6", "Has a cytoskeleton-independent function in chemotactic signaling during development." ], [ "Q550F6-1", "protein_xref_pubmed", "21034843", "Has a cytoskeleton-independent function in chemotactic signaling during development." ], [ "Q86K84-1", "protein_xref_uniprotkb_fun", "Q86K84", "Mediates the transfer of lipids between membranes at organelle contact sites." ], [ "Q86K84-1", "protein_xref_uniprotkb_fun", "Q07878", "Mediates the transfer of lipids between membranes at organelle contact sites." ], [ "Q86K86-1", "protein_xref_uniprotkb_fun", "Q86K86", "Transfers dimethylallyl groups to AMP as part of the biosynthesis of cytokinin phytohormones like isopentenyl adenine or discadenine which controle spore formation and viability." ], [ "Q86K86-1", "protein_xref_pubmed", "18216168", "Transfers dimethylallyl groups to AMP as part of the biosynthesis of cytokinin phytohormones like isopentenyl adenine or discadenine which controle spore formation and viability." ], [ "Q86A24-1", "protein_xref_uniprotkb_fun", "Q86A24", "S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha." ], [ "Q86A24-1", "protein_xref_uniprotkb_fun", "MF_03187", "S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha." ], [ "Q86A21-1", "protein_xref_uniprotkb_fun", "Q86A21", "Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)." ], [ "P34045-1", "protein_xref_uniprotkb_fun", "P34045", "Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems." ], [ "P20610-1", "protein_xref_uniprotkb_fun", "P20610", "This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport." ], [ "P34046-1", "protein_xref_uniprotkb_fun", "P34046", "Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-8 is a potential analog for the G(s)-like G-proteins which stimulate adenylate cyclase in mammals." ], [ "Q550A8-1", "protein_xref_uniprotkb_fun", "Q550A8", "E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), and autophagy. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of atg8. The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8 from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8. The formation of the atg8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt) (By similarity)." ], [ "P34043-1", "protein_xref_uniprotkb_fun", "P34043", "Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems." ], [ "P34042-1", "protein_xref_uniprotkb_fun", "P34042", "Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-4 plays a role in morphogenesis of the multicellular structure." ], [ "Q550A6-1", "protein_xref_uniprotkb_fun", "Q550A6", "May regulate endogenous transporter." ], [ "Q557I1-1", "protein_xref_uniprotkb_fun", "Q557I1", "Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters." ], [ "Q55FG3-1", "protein_xref_uniprotkb_fun", "Q55FG3", "Mediates the transfer of lipids between membranes at organelle contact sites." ], [ "Q55FG3-1", "protein_xref_uniprotkb_fun", "Q07878", "Mediates the transfer of lipids between membranes at organelle contact sites." ], [ "Q54YV1-1", "protein_xref_uniprotkb_fun", "Q54YV1", "Rho GTPase-activating protein involved in the signal transduction pathway." ], [ "P03967-1", "protein_xref_uniprotkb_fun", "P03967", "Ras proteins bind GDP/GTP and possess intrinsic GTPase activity." ], [ "P03967-1", "protein_xref_pubmed", "18948008", "Ras proteins bind GDP/GTP and possess intrinsic GTPase activity." ], [ "Q54YV7-1", "protein_xref_uniprotkb_fun", "Q54YV7", "May be involved in trafficking events within the endosomal system." ], [ "Q557G3-1", "protein_xref_uniprotkb_fun", "Q557G3", "May play a role in vesicular transport from endoplasmic reticulum to Golgi." ], [ "Q54YV4-1", "protein_xref_uniprotkb_fun", "Q54YV4", "ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner." ], [ "Q54YV4-1", "protein_xref_uniprotkb_fun", "MF_03120", "ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner." ] ] }, "readme": "Name\n - Dicty Protein Function (UniProtKB)\n\nVersion\n - v-2.4.1\n\nCreated on\n - \n\nModified on\n - 2024-01-09T04:31:12\n\nCreated by\n - Jeet Vora [jeetvora@gwu.edu], Karina Martinez [karinamartinez@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Luke Johnson [luke.johnson@email.gwu.edu], Urnisha Bhuiyan [sbhuiyan28@email.gwu.edu], Cyrus Au-Yeung [cyruschauyeung@gwu.edu], Jingyue Wu [jingyue.wu@email.gwu.edu]\n\nAuthors\n - \n\nChecksum\n - \n\nUsability Domain\n - The Dicty Protein Function (UniProtKB) dataset contains biological function annotation for dicty [taxid:44689] protein accessions from the UniProtKB database. The dataset is derived from 2019-09 UniProtKB release. If you use this dataset please provide proper attribution to EMBL-EBI-UniProtKB and GlyGen\n\nDescription Domain\n Keywords\n - protein function\n - UniProtKB\n\n Pipeline Steps\n - Step-1: The script loads the UniProtKB function annotations triplestore containing triples from nt file and extracts the data as a csv dataset\n\nExecution Domain\n Scripts - https://github.com/glygener/glygen-backend-integration/blob/master/dataset-maker/make-protein-dataset.py\n\n\n Software Prerequisites\n Name: Python\n Version: 2.7.5\n URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n Input Subdomain\n Name: uniprot-proteome-dictyostelium-discoideum.nt\n URI: https:/data.glygen.org/ln2downloads/ebi/2024_02_19/uniprot-proteome-dictyostelium-discoideum.nt\n Output Subdomain\n Name: dicty_protein_function_uniprotkb.csv\n URI: https:/data.glygen.org/ln2releases/data/v-2.4.1/reviewed/dicty_protein_function_uniprotkb.csv\n Name: dicty_protein_function_uniprotkb.stat.csv\n URI: https:/data.glygen.org/ln2releases/data/v-2.4.1/reviewed/dicty_protein_function_uniprotkb.stat.csv\n\nFields\n Name: \"uniprotkb_canonical_ac\"\n Description: \"\"\n Unique Values: \"2407\"\n Name: \"xref_key\"\n Description: \"Source key associated to the xref_id\"\n Unique Values: \"2\"\n Name: \"xref_id\"\n Description: \"ID of the X-ref\"\n Unique Values: \"3575\"\n Name: \"annotation\"\n Description: \"Function annotation from UniProtKB|RefSeq database\"\n Unique Values: \"1687\"", "downloadurl": "/ln2data/releases/data/v-2.4.1/reviewed/dicty_protein_function_uniprotkb.csv" }