{ "bcoid": "GLY_000625", "title": "Human Protein Biomarkers (Biomarker Database)", "description": "This is a Human Protein Biomarkers dataset. It contains human [taxonomy:9606] protein biomarker information, ...", "filename": "human_protein_biomarkers.csv", "filetype": "csv", "categories": { "species": [ "Homo sapiens" ], "molecule": [ "Protein" ], "tag": [ "Cancer Biomarker (BiomarkerDB)" ], "file_type": [ "csv" ], "status": [ "Reviewed" ], "scope": [ "internal" ] }, "minitable": { "content": [ [ "P05231-1...", "A0001..." ], [ "P05231-1...", "A0001..." ] ], "headers": [ "uniprotkb_ca...", "biomarker_id..." ], "colwidth": [ "40%", "20%" ] }, "sampledata": { "type": "table", "data": [ [ { "type": "string", "label": "uniprotkb_canonical_ac" }, { "type": "string", "label": "biomarker_id" }, { "type": "string", "label": "assessed_biomarker_entity" }, { "type": "string", "label": "biomarker" }, { "type": "string", "label": "best_biomarker_type" }, { "type": "string", "label": "loinc_code" }, { "type": "string", "label": "notes" }, { "type": "string", "label": "literature_evidence" }, { "type": "string", "label": "anatomical_entity" }, { "type": "string", "label": "uberon_id" }, { "type": "string", "label": "do_id" }, { "type": "string", "label": "do_name" }, { "type": "string", "label": "assessed_entity_type" }, { "type": "string", "label": "xref_key" }, { "type": "string", "label": "xref_id" }, { "type": "string", "label": "src_xref_key" }, { "type": "string", "label": "src_xref_id" } ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "", "Univariate analysis of all patients demonstrated that an extent of disease (EOD) on bone scanning > or = 1, IL-6 > or = 7 pg/ml, PS > or = 1, PSA > 100 ng/ml, and ALP > 620 IU/liter were associated with a significantly lower survival rate than their respective counterparts. In multivariate analysis, however, the only two significant prognostic factors were EOD and IL-6. These results indicate that the serum IL-6 level is a significant prognostic factor for prostate cancer as well as EOD. [PMID:10914713]", "blood", "0000178", "10283", "DOID:10283 / Prostate Cancer", "protein", "protein_xref_biomarkerdb", "A0001", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "", "Univariate analysis of all patients demonstrated that an extent of disease (EOD) on bone scanning > or = 1, IL-6 > or = 7 pg/ml, PS > or = 1, PSA > 100 ng/ml, and ALP > 620 IU/liter were associated with a significantly lower survival rate than their respective counterparts. In multivariate analysis, however, the only two significant prognostic factors were EOD and IL-6. These results indicate that the serum IL-6 level is a significant prognostic factor for prostate cancer as well as EOD. [PMID:10914713]", "blood", "0000178", "10283", "DOID:10283 / Prostate Cancer", "protein", "protein_xref_pubmed", "10914713", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "monitoring", "26881-3", "Measured in serum (UN:0001977) as well.", "Serial measurement of circulating IL-6 levels may be important in identifying disease progression among COVID-19-infected patients. [PMID:32259560] The decrease of IL-6 was closely related to treatment effectiveness, while the increase of IL-6 indicated disease exacerbation. Collectively, the dynamic change of IL-6 level can be used as a marker for disease monitoring in patients with severe COVID-19. [PMID:32428990] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] Clinical biomarkers for chronic inflammation, in particular Interleukin-6, predict the severity of COVID-19. [PMID:32438331] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] Interleukin-6 (IL-6) plays an important role in cytokine release syndrome. If it is possible to block the signal transduction pathway of IL-6, it is expected to become a new method for the treatment of severe COVID-19 patients. [PMID:32234467] findings in this study include determining independent associations between biomarkers for inflammation (interleukin-6) and thrombosis (D-dimer) and mortality. [PMID:32442528] lower lymphocyte counts, higher leukocyte counts and neutrophil-lymphocyte ratio (NLR), lower monocytes, eosinophils, and basophils elevated inflammatory cytokines. T cells significantly decreased, helper T (Th) cells and suppressor T cells were below normal levels naive Th cells increased and memory Th cells decreased. lower levels of regulatory T cells. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] Since the proportionate rise of IL-6 is correlated with disease severity, this study can prove ground-breaking. [PMID:32475810] Up-regulated IL-6 levels may serve as a potential marker for predicting progression of COVID19 patients. [PMID:32385523] IL-6 and d-D were closely related to the occurrence of severe COVID-19 in the adult patients, and their combined detection had the highest specificity and sensitivity for early prediction of the severity of COVID-19 patients, which has important clinical value. [PMID:32181911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_biomarkerdb", "A0001", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "monitoring", "26881-3", "Measured in serum (UN:0001977) as well.", "Serial measurement of circulating IL-6 levels may be important in identifying disease progression among COVID-19-infected patients. [PMID:32259560] The decrease of IL-6 was closely related to treatment effectiveness, while the increase of IL-6 indicated disease exacerbation. Collectively, the dynamic change of IL-6 level can be used as a marker for disease monitoring in patients with severe COVID-19. [PMID:32428990] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] Clinical biomarkers for chronic inflammation, in particular Interleukin-6, predict the severity of COVID-19. [PMID:32438331] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] Interleukin-6 (IL-6) plays an important role in cytokine release syndrome. If it is possible to block the signal transduction pathway of IL-6, it is expected to become a new method for the treatment of severe COVID-19 patients. [PMID:32234467] findings in this study include determining independent associations between biomarkers for inflammation (interleukin-6) and thrombosis (D-dimer) and mortality. [PMID:32442528] lower lymphocyte counts, higher leukocyte counts and neutrophil-lymphocyte ratio (NLR), lower monocytes, eosinophils, and basophils elevated inflammatory cytokines. T cells significantly decreased, helper T (Th) cells and suppressor T cells were below normal levels naive Th cells increased and memory Th cells decreased. lower levels of regulatory T cells. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] Since the proportionate rise of IL-6 is correlated with disease severity, this study can prove ground-breaking. [PMID:32475810] Up-regulated IL-6 levels may serve as a potential marker for predicting progression of COVID19 patients. [PMID:32385523] IL-6 and d-D were closely related to the occurrence of severe COVID-19 in the adult patients, and their combined detection had the highest specificity and sensitivity for early prediction of the severity of COVID-19 patients, which has important clinical value. [PMID:32181911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32259560", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "monitoring", "26881-3", "Measured in serum (UN:0001977) as well.", "Serial measurement of circulating IL-6 levels may be important in identifying disease progression among COVID-19-infected patients. [PMID:32259560] The decrease of IL-6 was closely related to treatment effectiveness, while the increase of IL-6 indicated disease exacerbation. Collectively, the dynamic change of IL-6 level can be used as a marker for disease monitoring in patients with severe COVID-19. [PMID:32428990] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] Clinical biomarkers for chronic inflammation, in particular Interleukin-6, predict the severity of COVID-19. [PMID:32438331] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] Interleukin-6 (IL-6) plays an important role in cytokine release syndrome. If it is possible to block the signal transduction pathway of IL-6, it is expected to become a new method for the treatment of severe COVID-19 patients. [PMID:32234467] findings in this study include determining independent associations between biomarkers for inflammation (interleukin-6) and thrombosis (D-dimer) and mortality. [PMID:32442528] lower lymphocyte counts, higher leukocyte counts and neutrophil-lymphocyte ratio (NLR), lower monocytes, eosinophils, and basophils elevated inflammatory cytokines. T cells significantly decreased, helper T (Th) cells and suppressor T cells were below normal levels naive Th cells increased and memory Th cells decreased. lower levels of regulatory T cells. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] Since the proportionate rise of IL-6 is correlated with disease severity, this study can prove ground-breaking. [PMID:32475810] Up-regulated IL-6 levels may serve as a potential marker for predicting progression of COVID19 patients. [PMID:32385523] IL-6 and d-D were closely related to the occurrence of severe COVID-19 in the adult patients, and their combined detection had the highest specificity and sensitivity for early prediction of the severity of COVID-19 patients, which has important clinical value. [PMID:32181911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32428990", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "monitoring", "26881-3", "Measured in serum (UN:0001977) as well.", "Serial measurement of circulating IL-6 levels may be important in identifying disease progression among COVID-19-infected patients. [PMID:32259560] The decrease of IL-6 was closely related to treatment effectiveness, while the increase of IL-6 indicated disease exacerbation. Collectively, the dynamic change of IL-6 level can be used as a marker for disease monitoring in patients with severe COVID-19. [PMID:32428990] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] Clinical biomarkers for chronic inflammation, in particular Interleukin-6, predict the severity of COVID-19. [PMID:32438331] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] Interleukin-6 (IL-6) plays an important role in cytokine release syndrome. If it is possible to block the signal transduction pathway of IL-6, it is expected to become a new method for the treatment of severe COVID-19 patients. [PMID:32234467] findings in this study include determining independent associations between biomarkers for inflammation (interleukin-6) and thrombosis (D-dimer) and mortality. [PMID:32442528] lower lymphocyte counts, higher leukocyte counts and neutrophil-lymphocyte ratio (NLR), lower monocytes, eosinophils, and basophils elevated inflammatory cytokines. T cells significantly decreased, helper T (Th) cells and suppressor T cells were below normal levels naive Th cells increased and memory Th cells decreased. lower levels of regulatory T cells. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] Since the proportionate rise of IL-6 is correlated with disease severity, this study can prove ground-breaking. [PMID:32475810] Up-regulated IL-6 levels may serve as a potential marker for predicting progression of COVID19 patients. [PMID:32385523] IL-6 and d-D were closely related to the occurrence of severe COVID-19 in the adult patients, and their combined detection had the highest specificity and sensitivity for early prediction of the severity of COVID-19 patients, which has important clinical value. [PMID:32181911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32677844", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "monitoring", "26881-3", "Measured in serum (UN:0001977) as well.", "Serial measurement of circulating IL-6 levels may be important in identifying disease progression among COVID-19-infected patients. [PMID:32259560] The decrease of IL-6 was closely related to treatment effectiveness, while the increase of IL-6 indicated disease exacerbation. Collectively, the dynamic change of IL-6 level can be used as a marker for disease monitoring in patients with severe COVID-19. [PMID:32428990] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] Clinical biomarkers for chronic inflammation, in particular Interleukin-6, predict the severity of COVID-19. [PMID:32438331] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] Interleukin-6 (IL-6) plays an important role in cytokine release syndrome. If it is possible to block the signal transduction pathway of IL-6, it is expected to become a new method for the treatment of severe COVID-19 patients. [PMID:32234467] findings in this study include determining independent associations between biomarkers for inflammation (interleukin-6) and thrombosis (D-dimer) and mortality. [PMID:32442528] lower lymphocyte counts, higher leukocyte counts and neutrophil-lymphocyte ratio (NLR), lower monocytes, eosinophils, and basophils elevated inflammatory cytokines. T cells significantly decreased, helper T (Th) cells and suppressor T cells were below normal levels naive Th cells increased and memory Th cells decreased. lower levels of regulatory T cells. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] Since the proportionate rise of IL-6 is correlated with disease severity, this study can prove ground-breaking. [PMID:32475810] Up-regulated IL-6 levels may serve as a potential marker for predicting progression of COVID19 patients. [PMID:32385523] IL-6 and d-D were closely related to the occurrence of severe COVID-19 in the adult patients, and their combined detection had the highest specificity and sensitivity for early prediction of the severity of COVID-19 patients, which has important clinical value. [PMID:32181911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32438331", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "monitoring", "26881-3", "Measured in serum (UN:0001977) as well.", "Serial measurement of circulating IL-6 levels may be important in identifying disease progression among COVID-19-infected patients. [PMID:32259560] The decrease of IL-6 was closely related to treatment effectiveness, while the increase of IL-6 indicated disease exacerbation. Collectively, the dynamic change of IL-6 level can be used as a marker for disease monitoring in patients with severe COVID-19. [PMID:32428990] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] Clinical biomarkers for chronic inflammation, in particular Interleukin-6, predict the severity of COVID-19. [PMID:32438331] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] Interleukin-6 (IL-6) plays an important role in cytokine release syndrome. If it is possible to block the signal transduction pathway of IL-6, it is expected to become a new method for the treatment of severe COVID-19 patients. [PMID:32234467] findings in this study include determining independent associations between biomarkers for inflammation (interleukin-6) and thrombosis (D-dimer) and mortality. [PMID:32442528] lower lymphocyte counts, higher leukocyte counts and neutrophil-lymphocyte ratio (NLR), lower monocytes, eosinophils, and basophils elevated inflammatory cytokines. T cells significantly decreased, helper T (Th) cells and suppressor T cells were below normal levels naive Th cells increased and memory Th cells decreased. lower levels of regulatory T cells. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] Since the proportionate rise of IL-6 is correlated with disease severity, this study can prove ground-breaking. [PMID:32475810] Up-regulated IL-6 levels may serve as a potential marker for predicting progression of COVID19 patients. [PMID:32385523] IL-6 and d-D were closely related to the occurrence of severe COVID-19 in the adult patients, and their combined detection had the highest specificity and sensitivity for early prediction of the severity of COVID-19 patients, which has important clinical value. [PMID:32181911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32475810", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "monitoring", "26881-3", "Measured in serum (UN:0001977) as well.", "Serial measurement of circulating IL-6 levels may be important in identifying disease progression among COVID-19-infected patients. [PMID:32259560] The decrease of IL-6 was closely related to treatment effectiveness, while the increase of IL-6 indicated disease exacerbation. Collectively, the dynamic change of IL-6 level can be used as a marker for disease monitoring in patients with severe COVID-19. [PMID:32428990] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] Clinical biomarkers for chronic inflammation, in particular Interleukin-6, predict the severity of COVID-19. [PMID:32438331] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] Interleukin-6 (IL-6) plays an important role in cytokine release syndrome. If it is possible to block the signal transduction pathway of IL-6, it is expected to become a new method for the treatment of severe COVID-19 patients. [PMID:32234467] findings in this study include determining independent associations between biomarkers for inflammation (interleukin-6) and thrombosis (D-dimer) and mortality. [PMID:32442528] lower lymphocyte counts, higher leukocyte counts and neutrophil-lymphocyte ratio (NLR), lower monocytes, eosinophils, and basophils elevated inflammatory cytokines. T cells significantly decreased, helper T (Th) cells and suppressor T cells were below normal levels naive Th cells increased and memory Th cells decreased. lower levels of regulatory T cells. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] Since the proportionate rise of IL-6 is correlated with disease severity, this study can prove ground-breaking. [PMID:32475810] Up-regulated IL-6 levels may serve as a potential marker for predicting progression of COVID19 patients. [PMID:32385523] IL-6 and d-D were closely related to the occurrence of severe COVID-19 in the adult patients, and their combined detection had the highest specificity and sensitivity for early prediction of the severity of COVID-19 patients, which has important clinical value. [PMID:32181911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32234467", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "monitoring", "26881-3", "Measured in serum (UN:0001977) as well.", "Serial measurement of circulating IL-6 levels may be important in identifying disease progression among COVID-19-infected patients. [PMID:32259560] The decrease of IL-6 was closely related to treatment effectiveness, while the increase of IL-6 indicated disease exacerbation. Collectively, the dynamic change of IL-6 level can be used as a marker for disease monitoring in patients with severe COVID-19. [PMID:32428990] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] Clinical biomarkers for chronic inflammation, in particular Interleukin-6, predict the severity of COVID-19. [PMID:32438331] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] Interleukin-6 (IL-6) plays an important role in cytokine release syndrome. If it is possible to block the signal transduction pathway of IL-6, it is expected to become a new method for the treatment of severe COVID-19 patients. [PMID:32234467] findings in this study include determining independent associations between biomarkers for inflammation (interleukin-6) and thrombosis (D-dimer) and mortality. [PMID:32442528] lower lymphocyte counts, higher leukocyte counts and neutrophil-lymphocyte ratio (NLR), lower monocytes, eosinophils, and basophils elevated inflammatory cytokines. T cells significantly decreased, helper T (Th) cells and suppressor T cells were below normal levels naive Th cells increased and memory Th cells decreased. lower levels of regulatory T cells. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] Since the proportionate rise of IL-6 is correlated with disease severity, this study can prove ground-breaking. [PMID:32475810] Up-regulated IL-6 levels may serve as a potential marker for predicting progression of COVID19 patients. [PMID:32385523] IL-6 and d-D were closely related to the occurrence of severe COVID-19 in the adult patients, and their combined detection had the highest specificity and sensitivity for early prediction of the severity of COVID-19 patients, which has important clinical value. [PMID:32181911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32442528", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "monitoring", "26881-3", "Measured in serum (UN:0001977) as well.", "Serial measurement of circulating IL-6 levels may be important in identifying disease progression among COVID-19-infected patients. [PMID:32259560] The decrease of IL-6 was closely related to treatment effectiveness, while the increase of IL-6 indicated disease exacerbation. Collectively, the dynamic change of IL-6 level can be used as a marker for disease monitoring in patients with severe COVID-19. [PMID:32428990] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] Clinical biomarkers for chronic inflammation, in particular Interleukin-6, predict the severity of COVID-19. [PMID:32438331] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] Interleukin-6 (IL-6) plays an important role in cytokine release syndrome. If it is possible to block the signal transduction pathway of IL-6, it is expected to become a new method for the treatment of severe COVID-19 patients. [PMID:32234467] findings in this study include determining independent associations between biomarkers for inflammation (interleukin-6) and thrombosis (D-dimer) and mortality. [PMID:32442528] lower lymphocyte counts, higher leukocyte counts and neutrophil-lymphocyte ratio (NLR), lower monocytes, eosinophils, and basophils elevated inflammatory cytokines. T cells significantly decreased, helper T (Th) cells and suppressor T cells were below normal levels naive Th cells increased and memory Th cells decreased. lower levels of regulatory T cells. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] Since the proportionate rise of IL-6 is correlated with disease severity, this study can prove ground-breaking. [PMID:32475810] Up-regulated IL-6 levels may serve as a potential marker for predicting progression of COVID19 patients. [PMID:32385523] IL-6 and d-D were closely related to the occurrence of severe COVID-19 in the adult patients, and their combined detection had the highest specificity and sensitivity for early prediction of the severity of COVID-19 patients, which has important clinical value. [PMID:32181911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32161940", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "monitoring", "26881-3", "Measured in serum (UN:0001977) as well.", "Serial measurement of circulating IL-6 levels may be important in identifying disease progression among COVID-19-infected patients. [PMID:32259560] The decrease of IL-6 was closely related to treatment effectiveness, while the increase of IL-6 indicated disease exacerbation. Collectively, the dynamic change of IL-6 level can be used as a marker for disease monitoring in patients with severe COVID-19. [PMID:32428990] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] Clinical biomarkers for chronic inflammation, in particular Interleukin-6, predict the severity of COVID-19. [PMID:32438331] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] Interleukin-6 (IL-6) plays an important role in cytokine release syndrome. If it is possible to block the signal transduction pathway of IL-6, it is expected to become a new method for the treatment of severe COVID-19 patients. [PMID:32234467] findings in this study include determining independent associations between biomarkers for inflammation (interleukin-6) and thrombosis (D-dimer) and mortality. [PMID:32442528] lower lymphocyte counts, higher leukocyte counts and neutrophil-lymphocyte ratio (NLR), lower monocytes, eosinophils, and basophils elevated inflammatory cytokines. T cells significantly decreased, helper T (Th) cells and suppressor T cells were below normal levels naive Th cells increased and memory Th cells decreased. lower levels of regulatory T cells. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] Since the proportionate rise of IL-6 is correlated with disease severity, this study can prove ground-breaking. [PMID:32475810] Up-regulated IL-6 levels may serve as a potential marker for predicting progression of COVID19 patients. [PMID:32385523] IL-6 and d-D were closely related to the occurrence of severe COVID-19 in the adult patients, and their combined detection had the highest specificity and sensitivity for early prediction of the severity of COVID-19 patients, which has important clinical value. [PMID:32181911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32425269", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "monitoring", "26881-3", "Measured in serum (UN:0001977) as well.", "Serial measurement of circulating IL-6 levels may be important in identifying disease progression among COVID-19-infected patients. [PMID:32259560] The decrease of IL-6 was closely related to treatment effectiveness, while the increase of IL-6 indicated disease exacerbation. Collectively, the dynamic change of IL-6 level can be used as a marker for disease monitoring in patients with severe COVID-19. [PMID:32428990] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] Clinical biomarkers for chronic inflammation, in particular Interleukin-6, predict the severity of COVID-19. [PMID:32438331] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] Interleukin-6 (IL-6) plays an important role in cytokine release syndrome. If it is possible to block the signal transduction pathway of IL-6, it is expected to become a new method for the treatment of severe COVID-19 patients. [PMID:32234467] findings in this study include determining independent associations between biomarkers for inflammation (interleukin-6) and thrombosis (D-dimer) and mortality. [PMID:32442528] lower lymphocyte counts, higher leukocyte counts and neutrophil-lymphocyte ratio (NLR), lower monocytes, eosinophils, and basophils elevated inflammatory cytokines. T cells significantly decreased, helper T (Th) cells and suppressor T cells were below normal levels naive Th cells increased and memory Th cells decreased. lower levels of regulatory T cells. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] Since the proportionate rise of IL-6 is correlated with disease severity, this study can prove ground-breaking. [PMID:32475810] Up-regulated IL-6 levels may serve as a potential marker for predicting progression of COVID19 patients. [PMID:32385523] IL-6 and d-D were closely related to the occurrence of severe COVID-19 in the adult patients, and their combined detection had the highest specificity and sensitivity for early prediction of the severity of COVID-19 patients, which has important clinical value. [PMID:32181911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32475810", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "monitoring", "26881-3", "Measured in serum (UN:0001977) as well.", "Serial measurement of circulating IL-6 levels may be important in identifying disease progression among COVID-19-infected patients. [PMID:32259560] The decrease of IL-6 was closely related to treatment effectiveness, while the increase of IL-6 indicated disease exacerbation. Collectively, the dynamic change of IL-6 level can be used as a marker for disease monitoring in patients with severe COVID-19. [PMID:32428990] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] Clinical biomarkers for chronic inflammation, in particular Interleukin-6, predict the severity of COVID-19. [PMID:32438331] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] Interleukin-6 (IL-6) plays an important role in cytokine release syndrome. If it is possible to block the signal transduction pathway of IL-6, it is expected to become a new method for the treatment of severe COVID-19 patients. [PMID:32234467] findings in this study include determining independent associations between biomarkers for inflammation (interleukin-6) and thrombosis (D-dimer) and mortality. [PMID:32442528] lower lymphocyte counts, higher leukocyte counts and neutrophil-lymphocyte ratio (NLR), lower monocytes, eosinophils, and basophils elevated inflammatory cytokines. T cells significantly decreased, helper T (Th) cells and suppressor T cells were below normal levels naive Th cells increased and memory Th cells decreased. lower levels of regulatory T cells. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] Since the proportionate rise of IL-6 is correlated with disease severity, this study can prove ground-breaking. [PMID:32475810] Up-regulated IL-6 levels may serve as a potential marker for predicting progression of COVID19 patients. [PMID:32385523] IL-6 and d-D were closely related to the occurrence of severe COVID-19 in the adult patients, and their combined detection had the highest specificity and sensitivity for early prediction of the severity of COVID-19 patients, which has important clinical value. [PMID:32181911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32385523", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "monitoring", "26881-3", "Measured in serum (UN:0001977) as well.", "Serial measurement of circulating IL-6 levels may be important in identifying disease progression among COVID-19-infected patients. [PMID:32259560] The decrease of IL-6 was closely related to treatment effectiveness, while the increase of IL-6 indicated disease exacerbation. Collectively, the dynamic change of IL-6 level can be used as a marker for disease monitoring in patients with severe COVID-19. [PMID:32428990] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] Clinical biomarkers for chronic inflammation, in particular Interleukin-6, predict the severity of COVID-19. [PMID:32438331] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] Interleukin-6 (IL-6) plays an important role in cytokine release syndrome. If it is possible to block the signal transduction pathway of IL-6, it is expected to become a new method for the treatment of severe COVID-19 patients. [PMID:32234467] findings in this study include determining independent associations between biomarkers for inflammation (interleukin-6) and thrombosis (D-dimer) and mortality. [PMID:32442528] lower lymphocyte counts, higher leukocyte counts and neutrophil-lymphocyte ratio (NLR), lower monocytes, eosinophils, and basophils elevated inflammatory cytokines. T cells significantly decreased, helper T (Th) cells and suppressor T cells were below normal levels naive Th cells increased and memory Th cells decreased. lower levels of regulatory T cells. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] Since the proportionate rise of IL-6 is correlated with disease severity, this study can prove ground-breaking. [PMID:32475810] Up-regulated IL-6 levels may serve as a potential marker for predicting progression of COVID19 patients. [PMID:32385523] IL-6 and d-D were closely related to the occurrence of severe COVID-19 in the adult patients, and their combined detection had the highest specificity and sensitivity for early prediction of the severity of COVID-19 patients, which has important clinical value. [PMID:32181911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32181911", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well.", "A deep network analysis has suggested clinical biomarkers predicting the higher risk of severe COVID-19 infection: Hypertension, elevated serum Alanine aminotransferase, high Interleukin-6, and low Lymphocytes count. In particular, patients with diabetes, but also those with prediabetic state, deserve special attention. [PMID:32438331] The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. [PMID:32344321] In hospitalized patients with respiratory distress, we recommend clinicians closely monitor WBC count, lymphocyte count, platelet count, IL-6 and serum ferritin as markers for potential progression to critical illness. [PMID:32286245]", "blood", "0000178", "0080600", "", "protein", "protein_xref_biomarkerdb", "A0001", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well.", "A deep network analysis has suggested clinical biomarkers predicting the higher risk of severe COVID-19 infection: Hypertension, elevated serum Alanine aminotransferase, high Interleukin-6, and low Lymphocytes count. In particular, patients with diabetes, but also those with prediabetic state, deserve special attention. [PMID:32438331] The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. [PMID:32344321] In hospitalized patients with respiratory distress, we recommend clinicians closely monitor WBC count, lymphocyte count, platelet count, IL-6 and serum ferritin as markers for potential progression to critical illness. [PMID:32286245]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32438331", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well.", "A deep network analysis has suggested clinical biomarkers predicting the higher risk of severe COVID-19 infection: Hypertension, elevated serum Alanine aminotransferase, high Interleukin-6, and low Lymphocytes count. In particular, patients with diabetes, but also those with prediabetic state, deserve special attention. [PMID:32438331] The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. [PMID:32344321] In hospitalized patients with respiratory distress, we recommend clinicians closely monitor WBC count, lymphocyte count, platelet count, IL-6 and serum ferritin as markers for potential progression to critical illness. [PMID:32286245]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32344321", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well.", "A deep network analysis has suggested clinical biomarkers predicting the higher risk of severe COVID-19 infection: Hypertension, elevated serum Alanine aminotransferase, high Interleukin-6, and low Lymphocytes count. In particular, patients with diabetes, but also those with prediabetic state, deserve special attention. [PMID:32438331] The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. [PMID:32344321] In hospitalized patients with respiratory distress, we recommend clinicians closely monitor WBC count, lymphocyte count, platelet count, IL-6 and serum ferritin as markers for potential progression to critical illness. [PMID:32286245]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32286245", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "1324", "DOID:1324 / Lung Cancer", "protein", "protein_xref_biomarkerdb", "A0001", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "1324", "DOID:1324 / Lung Cancer", "protein", "protein_xref_pubmed", "32479790", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "1324", "DOID:1324 / Lung Cancer", "protein", "protein_xref_pubmed", "32369209", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "11054", "DOID:11054 / Urinary Bladder Cancer", "protein", "protein_xref_biomarkerdb", "A0001", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "11054", "DOID:11054 / Urinary Bladder Cancer", "protein", "protein_xref_pubmed", "32479790", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "11054", "DOID:11054 / Urinary Bladder Cancer", "protein", "protein_xref_pubmed", "32369209", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "1612", "DOID:1612 / Breast Cancer", "protein", "protein_xref_biomarkerdb", "A0001", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "1612", "DOID:1612 / Breast Cancer", "protein", "protein_xref_pubmed", "32479790", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "1612", "DOID:1612 / Breast Cancer", "protein", "protein_xref_pubmed", "32369209", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "9256", "DOID:9256 / Colorectal Cancer", "protein", "protein_xref_biomarkerdb", "A0001", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "9256", "DOID:9256 / Colorectal Cancer", "protein", "protein_xref_pubmed", "32479790", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "9256", "DOID:9256 / Colorectal Cancer", "protein", "protein_xref_pubmed", "32369209", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "1781", "DOID:1781 / Thyroid Gland Cancer", "protein", "protein_xref_biomarkerdb", "A0001", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "1781", "DOID:1781 / Thyroid Gland Cancer", "protein", "protein_xref_pubmed", "32479790", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "1781", "DOID:1781 / Thyroid Gland Cancer", "protein", "protein_xref_pubmed", "32369209", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "4362", "", "protein", "protein_xref_biomarkerdb", "A0001", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "4362", "", "protein", "protein_xref_pubmed", "32479790", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "4362", "", "protein", "protein_xref_pubmed", "32369209", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "263", "DOID:263 / Kidney Cancer", "protein", "protein_xref_biomarkerdb", "A0001", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "263", "DOID:263 / Kidney Cancer", "protein", "protein_xref_pubmed", "32479790", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "263", "DOID:263 / Kidney Cancer", "protein", "protein_xref_pubmed", "32369209", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "10283", "DOID:10283 / Prostate Cancer", "protein", "protein_xref_biomarkerdb", "A0001", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "10283", "DOID:10283 / Prostate Cancer", "protein", "protein_xref_pubmed", "32479790", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "10283", "DOID:10283 / Prostate Cancer", "protein", "protein_xref_pubmed", "32369209", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "3571", "DOID:3571 / Liver Cancer", "protein", "protein_xref_biomarkerdb", "A0001", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "3571", "DOID:3571 / Liver Cancer", "protein", "protein_xref_pubmed", "32479790", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "3571", "DOID:3571 / Liver Cancer", "protein", "protein_xref_pubmed", "32369209", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well|lymphoma (DOID:8584)", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "2531", "", "protein", "protein_xref_biomarkerdb", "A0001", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well|lymphoma (DOID:8584)", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "2531", "", "protein", "protein_xref_pubmed", "32479790", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well|lymphoma (DOID:8584)", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "2531", "", "protein", "protein_xref_pubmed", "32369209", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "5041", "DOID:5041 / Esophageal Cancer", "protein", "protein_xref_biomarkerdb", "A0001", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "5041", "DOID:5041 / Esophageal Cancer", "protein", "protein_xref_pubmed", "32479790", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "prognostic", "26881-3", "Measured in serum (UN:0001977) as well", "IL-6 plays multifaceted roles in regulation of vascular leakage, complement activation, and coagulation pathways, which ultimately causes poor outcomes for acute respiratory distress syndrome, multiple organ dysfunction syndrome, and SARS. [PMID:32479790] Low lymphocytes, increased IL-6, CRP, PCT, D dimer, and LDH, these finds were similar to previous studies. The increase of these inflammatory indexes indicates that the infected patients were in inflammatory state, which may be closely related to the inflammatory storm. The increase of the cancer biomarkers in patients with COVID-19, especially in severe and critical patients, suggests that inflammation is closely related to the development of COVID-19. [PMID:32369209]", "blood", "0000178", "5041", "DOID:5041 / Esophageal Cancer", "protein", "protein_xref_pubmed", "32369209", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "safety", "26881-3", "Measured in serum (UN:0001977) as well.", "The mean of glycemia during hospitalization was 10.65 \u00b1 0.84 mmol/L in the no insulin infusion group and 7.69 \u00b1 1.85 mmol/L in the insulin infusion group. At baseline, IL-6 and D-dimer levels were significantly higher in the hyperglycemic group than in the normoglycemic group (P < 0.001). Even though all patients were on standard treatment for COVID-19 infection, IL-6 and D-dimer levels persisted higher in patients with hyperglycemia during hospitalization. [PMID:32430456] Our study is suggestive of S100A8/A9 and IL-6 being related to a persistent diabetes status post-surgically and of different pathophysiological mechanisms being involved in the post-surgical changes in the three groups, despite similar decreases in BMI. [PMID:28848164] Significantly higher IL-15 and IL-6 concentrations, HOMAIR, and markedly lower eGDR in newly diagnosed AD patients and first-degree relatives with positive anti-islet antibodies might suggest the role of these pro-inflammatory cytokines and insulin resistance in the pathogenesis of autoimmune diabetes. IL-15 and IL-6 might be used as biomarkers of the risk of autoimmune diabetes development. [PMID:31772933]", "blood", "0000178", "9351", "", "protein", "protein_xref_biomarkerdb", "A0001", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "safety", "26881-3", "Measured in serum (UN:0001977) as well.", "The mean of glycemia during hospitalization was 10.65 \u00b1 0.84 mmol/L in the no insulin infusion group and 7.69 \u00b1 1.85 mmol/L in the insulin infusion group. At baseline, IL-6 and D-dimer levels were significantly higher in the hyperglycemic group than in the normoglycemic group (P < 0.001). Even though all patients were on standard treatment for COVID-19 infection, IL-6 and D-dimer levels persisted higher in patients with hyperglycemia during hospitalization. [PMID:32430456] Our study is suggestive of S100A8/A9 and IL-6 being related to a persistent diabetes status post-surgically and of different pathophysiological mechanisms being involved in the post-surgical changes in the three groups, despite similar decreases in BMI. [PMID:28848164] Significantly higher IL-15 and IL-6 concentrations, HOMAIR, and markedly lower eGDR in newly diagnosed AD patients and first-degree relatives with positive anti-islet antibodies might suggest the role of these pro-inflammatory cytokines and insulin resistance in the pathogenesis of autoimmune diabetes. IL-15 and IL-6 might be used as biomarkers of the risk of autoimmune diabetes development. [PMID:31772933]", "blood", "0000178", "9351", "", "protein", "protein_xref_pubmed", "32430456", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "safety", "26881-3", "Measured in serum (UN:0001977) as well.", "The mean of glycemia during hospitalization was 10.65 \u00b1 0.84 mmol/L in the no insulin infusion group and 7.69 \u00b1 1.85 mmol/L in the insulin infusion group. At baseline, IL-6 and D-dimer levels were significantly higher in the hyperglycemic group than in the normoglycemic group (P < 0.001). Even though all patients were on standard treatment for COVID-19 infection, IL-6 and D-dimer levels persisted higher in patients with hyperglycemia during hospitalization. [PMID:32430456] Our study is suggestive of S100A8/A9 and IL-6 being related to a persistent diabetes status post-surgically and of different pathophysiological mechanisms being involved in the post-surgical changes in the three groups, despite similar decreases in BMI. [PMID:28848164] Significantly higher IL-15 and IL-6 concentrations, HOMAIR, and markedly lower eGDR in newly diagnosed AD patients and first-degree relatives with positive anti-islet antibodies might suggest the role of these pro-inflammatory cytokines and insulin resistance in the pathogenesis of autoimmune diabetes. IL-15 and IL-6 might be used as biomarkers of the risk of autoimmune diabetes development. [PMID:31772933]", "blood", "0000178", "9351", "", "protein", "protein_xref_pubmed", "28848164", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "safety", "26881-3", "Measured in serum (UN:0001977) as well.", "The mean of glycemia during hospitalization was 10.65 \u00b1 0.84 mmol/L in the no insulin infusion group and 7.69 \u00b1 1.85 mmol/L in the insulin infusion group. At baseline, IL-6 and D-dimer levels were significantly higher in the hyperglycemic group than in the normoglycemic group (P < 0.001). Even though all patients were on standard treatment for COVID-19 infection, IL-6 and D-dimer levels persisted higher in patients with hyperglycemia during hospitalization. [PMID:32430456] Our study is suggestive of S100A8/A9 and IL-6 being related to a persistent diabetes status post-surgically and of different pathophysiological mechanisms being involved in the post-surgical changes in the three groups, despite similar decreases in BMI. [PMID:28848164] Significantly higher IL-15 and IL-6 concentrations, HOMAIR, and markedly lower eGDR in newly diagnosed AD patients and first-degree relatives with positive anti-islet antibodies might suggest the role of these pro-inflammatory cytokines and insulin resistance in the pathogenesis of autoimmune diabetes. IL-15 and IL-6 might be used as biomarkers of the risk of autoimmune diabetes development. [PMID:31772933]", "blood", "0000178", "9351", "", "protein", "protein_xref_pubmed", "31772933", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "risk", "26881-3", "Measured in serum (UN:0001977) as well.", "Significantly higher IL-15 and IL-6 concentrations, HOMAIR, and markedly lower eGDR in newly diagnosed AD patients and first-degree relatives with positive anti-islet antibodies might suggest the role of these pro-inflammatory cytokines and insulin resistance in the pathogenesis of autoimmune diabetes. IL-15 and IL-6 might be used as biomarkers of the risk of autoimmune diabetes development. [PMID:31772933]", "blood", "0000178", "9351", "", "protein", "protein_xref_biomarkerdb", "A0001", "protein_xref_biomarkerdb", "A0001" ], [ "P05231-1", "A0001", "Interleukin-6 (IL6)", "increased IL6 level", "risk", "26881-3", "Measured in serum (UN:0001977) as well.", "Significantly higher IL-15 and IL-6 concentrations, HOMAIR, and markedly lower eGDR in newly diagnosed AD patients and first-degree relatives with positive anti-islet antibodies might suggest the role of these pro-inflammatory cytokines and insulin resistance in the pathogenesis of autoimmune diabetes. IL-15 and IL-6 might be used as biomarkers of the risk of autoimmune diabetes development. [PMID:31772933]", "blood", "0000178", "9351", "", "protein", "protein_xref_pubmed", "31772933", "protein_xref_biomarkerdb", "A0001" ], [ "P02741-1", "A0009", "C-reactive protein (CRP)", "increased CRP level", "monitoring", "71426-1", "Measured in serum (UN:0001977) and plasma (UN:0001969) as well.", "SAA/L, CRP, SAA, and L count are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] The positive correlations between CRP and series cancer biomarkers we showed in this study demonstrate that these cancer biomarkers can present the diffuse and acute lung injuries in COVID-19. CRP increased in 95% of all cases; the increases were significant for all groups (mild: 13.5\u2009\u00b1\u200913.1; severe: 35.0\u2009\u00b1\u200939.2; critical: 66.1\u2009\u00b1\u200967.3; in mg/L; P\u2009=\u2009.002). [PMID:32347972] Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] With following parameters such as age >67.5 years, IL2R >793.5U/mL, CRP >30.7ng/mL, ferroprotein >2252ug/L, WBC>9.5x10^9/L or NC >7.305x10^9/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. [PMID:33349241] Surveillance of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis, and treatment of COVID-19. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] NLR and CRP are potential and reliable predictors of COVID-19 prognosis and can triage patients at the time of admission. [PMID:32566572] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] We found that old age, and higher serum lactate dehydrogenase, C-reactive protein, the coefficient of variation of red blood cell distribution width, blood urea nitrogen, direct bilirubin, lower albumin, are associated with severe COVID-19. [PMID:32296824] CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_biomarkerdb", "A0009", "protein_xref_biomarkerdb", "A0009" ], [ "P02741-1", "A0009", "C-reactive protein (CRP)", "increased CRP level", "monitoring", "71426-1", "Measured in serum (UN:0001977) and plasma (UN:0001969) as well.", "SAA/L, CRP, SAA, and L count are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] The positive correlations between CRP and series cancer biomarkers we showed in this study demonstrate that these cancer biomarkers can present the diffuse and acute lung injuries in COVID-19. CRP increased in 95% of all cases; the increases were significant for all groups (mild: 13.5\u2009\u00b1\u200913.1; severe: 35.0\u2009\u00b1\u200939.2; critical: 66.1\u2009\u00b1\u200967.3; in mg/L; P\u2009=\u2009.002). [PMID:32347972] Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] With following parameters such as age >67.5 years, IL2R >793.5U/mL, CRP >30.7ng/mL, ferroprotein >2252ug/L, WBC>9.5x10^9/L or NC >7.305x10^9/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. [PMID:33349241] Surveillance of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis, and treatment of COVID-19. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] NLR and CRP are potential and reliable predictors of COVID-19 prognosis and can triage patients at the time of admission. [PMID:32566572] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] We found that old age, and higher serum lactate dehydrogenase, C-reactive protein, the coefficient of variation of red blood cell distribution width, blood urea nitrogen, direct bilirubin, lower albumin, are associated with severe COVID-19. [PMID:32296824] CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32277967", "protein_xref_biomarkerdb", "A0009" ], [ "P02741-1", "A0009", "C-reactive protein (CRP)", "increased CRP level", "monitoring", "71426-1", "Measured in serum (UN:0001977) and plasma (UN:0001969) as well.", "SAA/L, CRP, SAA, and L count are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] The positive correlations between CRP and series cancer biomarkers we showed in this study demonstrate that these cancer biomarkers can present the diffuse and acute lung injuries in COVID-19. CRP increased in 95% of all cases; the increases were significant for all groups (mild: 13.5\u2009\u00b1\u200913.1; severe: 35.0\u2009\u00b1\u200939.2; critical: 66.1\u2009\u00b1\u200967.3; in mg/L; P\u2009=\u2009.002). [PMID:32347972] Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] With following parameters such as age >67.5 years, IL2R >793.5U/mL, CRP >30.7ng/mL, ferroprotein >2252ug/L, WBC>9.5x10^9/L or NC >7.305x10^9/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. [PMID:33349241] Surveillance of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis, and treatment of COVID-19. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] NLR and CRP are potential and reliable predictors of COVID-19 prognosis and can triage patients at the time of admission. [PMID:32566572] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] We found that old age, and higher serum lactate dehydrogenase, C-reactive protein, the coefficient of variation of red blood cell distribution width, blood urea nitrogen, direct bilirubin, lower albumin, are associated with severe COVID-19. [PMID:32296824] CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32677844", "protein_xref_biomarkerdb", "A0009" ], [ "P02741-1", "A0009", "C-reactive protein (CRP)", "increased CRP level", "monitoring", "71426-1", "Measured in serum (UN:0001977) and plasma (UN:0001969) as well.", "SAA/L, CRP, SAA, and L count are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] The positive correlations between CRP and series cancer biomarkers we showed in this study demonstrate that these cancer biomarkers can present the diffuse and acute lung injuries in COVID-19. CRP increased in 95% of all cases; the increases were significant for all groups (mild: 13.5\u2009\u00b1\u200913.1; severe: 35.0\u2009\u00b1\u200939.2; critical: 66.1\u2009\u00b1\u200967.3; in mg/L; P\u2009=\u2009.002). [PMID:32347972] Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] With following parameters such as age >67.5 years, IL2R >793.5U/mL, CRP >30.7ng/mL, ferroprotein >2252ug/L, WBC>9.5x10^9/L or NC >7.305x10^9/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. [PMID:33349241] Surveillance of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis, and treatment of COVID-19. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] NLR and CRP are potential and reliable predictors of COVID-19 prognosis and can triage patients at the time of admission. [PMID:32566572] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] We found that old age, and higher serum lactate dehydrogenase, C-reactive protein, the coefficient of variation of red blood cell distribution width, blood urea nitrogen, direct bilirubin, lower albumin, are associated with severe COVID-19. [PMID:32296824] CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32347972", "protein_xref_biomarkerdb", "A0009" ], [ "P02741-1", "A0009", "C-reactive protein (CRP)", "increased CRP level", "monitoring", "71426-1", "Measured in serum (UN:0001977) and plasma (UN:0001969) as well.", "SAA/L, CRP, SAA, and L count are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] The positive correlations between CRP and series cancer biomarkers we showed in this study demonstrate that these cancer biomarkers can present the diffuse and acute lung injuries in COVID-19. CRP increased in 95% of all cases; the increases were significant for all groups (mild: 13.5\u2009\u00b1\u200913.1; severe: 35.0\u2009\u00b1\u200939.2; critical: 66.1\u2009\u00b1\u200967.3; in mg/L; P\u2009=\u2009.002). [PMID:32347972] Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] With following parameters such as age >67.5 years, IL2R >793.5U/mL, CRP >30.7ng/mL, ferroprotein >2252ug/L, WBC>9.5x10^9/L or NC >7.305x10^9/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. [PMID:33349241] Surveillance of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis, and treatment of COVID-19. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] NLR and CRP are potential and reliable predictors of COVID-19 prognosis and can triage patients at the time of admission. [PMID:32566572] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] We found that old age, and higher serum lactate dehydrogenase, C-reactive protein, the coefficient of variation of red blood cell distribution width, blood urea nitrogen, direct bilirubin, lower albumin, are associated with severe COVID-19. [PMID:32296824] CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_doi", "10.1038/s42256-020-0180-7", "protein_xref_biomarkerdb", "A0009" ], [ "P02741-1", "A0009", "C-reactive protein (CRP)", "increased CRP level", "monitoring", "71426-1", "Measured in serum (UN:0001977) and plasma (UN:0001969) as well.", "SAA/L, CRP, SAA, and L count are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] The positive correlations between CRP and series cancer biomarkers we showed in this study demonstrate that these cancer biomarkers can present the diffuse and acute lung injuries in COVID-19. CRP increased in 95% of all cases; the increases were significant for all groups (mild: 13.5\u2009\u00b1\u200913.1; severe: 35.0\u2009\u00b1\u200939.2; critical: 66.1\u2009\u00b1\u200967.3; in mg/L; P\u2009=\u2009.002). [PMID:32347972] Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] With following parameters such as age >67.5 years, IL2R >793.5U/mL, CRP >30.7ng/mL, ferroprotein >2252ug/L, WBC>9.5x10^9/L or NC >7.305x10^9/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. [PMID:33349241] Surveillance of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis, and treatment of COVID-19. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] NLR and CRP are potential and reliable predictors of COVID-19 prognosis and can triage patients at the time of admission. [PMID:32566572] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] We found that old age, and higher serum lactate dehydrogenase, C-reactive protein, the coefficient of variation of red blood cell distribution width, blood urea nitrogen, direct bilirubin, lower albumin, are associated with severe COVID-19. [PMID:32296824] CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "33349241", "protein_xref_biomarkerdb", "A0009" ], [ "P02741-1", "A0009", "C-reactive protein (CRP)", "increased CRP level", "monitoring", "71426-1", "Measured in serum (UN:0001977) and plasma (UN:0001969) as well.", "SAA/L, CRP, SAA, and L count are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] The positive correlations between CRP and series cancer biomarkers we showed in this study demonstrate that these cancer biomarkers can present the diffuse and acute lung injuries in COVID-19. CRP increased in 95% of all cases; the increases were significant for all groups (mild: 13.5\u2009\u00b1\u200913.1; severe: 35.0\u2009\u00b1\u200939.2; critical: 66.1\u2009\u00b1\u200967.3; in mg/L; P\u2009=\u2009.002). [PMID:32347972] Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] With following parameters such as age >67.5 years, IL2R >793.5U/mL, CRP >30.7ng/mL, ferroprotein >2252ug/L, WBC>9.5x10^9/L or NC >7.305x10^9/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. [PMID:33349241] Surveillance of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis, and treatment of COVID-19. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] NLR and CRP are potential and reliable predictors of COVID-19 prognosis and can triage patients at the time of admission. [PMID:32566572] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] We found that old age, and higher serum lactate dehydrogenase, C-reactive protein, the coefficient of variation of red blood cell distribution width, blood urea nitrogen, direct bilirubin, lower albumin, are associated with severe COVID-19. [PMID:32296824] CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32161940", "protein_xref_biomarkerdb", "A0009" ], [ "P02741-1", "A0009", "C-reactive protein (CRP)", "increased CRP level", "monitoring", "71426-1", "Measured in serum (UN:0001977) and plasma (UN:0001969) as well.", "SAA/L, CRP, SAA, and L count are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] The positive correlations between CRP and series cancer biomarkers we showed in this study demonstrate that these cancer biomarkers can present the diffuse and acute lung injuries in COVID-19. CRP increased in 95% of all cases; the increases were significant for all groups (mild: 13.5\u2009\u00b1\u200913.1; severe: 35.0\u2009\u00b1\u200939.2; critical: 66.1\u2009\u00b1\u200967.3; in mg/L; P\u2009=\u2009.002). [PMID:32347972] Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] With following parameters such as age >67.5 years, IL2R >793.5U/mL, CRP >30.7ng/mL, ferroprotein >2252ug/L, WBC>9.5x10^9/L or NC >7.305x10^9/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. [PMID:33349241] Surveillance of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis, and treatment of COVID-19. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] NLR and CRP are potential and reliable predictors of COVID-19 prognosis and can triage patients at the time of admission. [PMID:32566572] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] We found that old age, and higher serum lactate dehydrogenase, C-reactive protein, the coefficient of variation of red blood cell distribution width, blood urea nitrogen, direct bilirubin, lower albumin, are associated with severe COVID-19. [PMID:32296824] CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32425269", "protein_xref_biomarkerdb", "A0009" ], [ "P02741-1", "A0009", "C-reactive protein (CRP)", "increased CRP level", "monitoring", "71426-1", "Measured in serum (UN:0001977) and plasma (UN:0001969) as well.", "SAA/L, CRP, SAA, and L count are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] The positive correlations between CRP and series cancer biomarkers we showed in this study demonstrate that these cancer biomarkers can present the diffuse and acute lung injuries in COVID-19. CRP increased in 95% of all cases; the increases were significant for all groups (mild: 13.5\u2009\u00b1\u200913.1; severe: 35.0\u2009\u00b1\u200939.2; critical: 66.1\u2009\u00b1\u200967.3; in mg/L; P\u2009=\u2009.002). [PMID:32347972] Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] With following parameters such as age >67.5 years, IL2R >793.5U/mL, CRP >30.7ng/mL, ferroprotein >2252ug/L, WBC>9.5x10^9/L or NC >7.305x10^9/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. [PMID:33349241] Surveillance of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis, and treatment of COVID-19. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] NLR and CRP are potential and reliable predictors of COVID-19 prognosis and can triage patients at the time of admission. [PMID:32566572] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] We found that old age, and higher serum lactate dehydrogenase, C-reactive protein, the coefficient of variation of red blood cell distribution width, blood urea nitrogen, direct bilirubin, lower albumin, are associated with severe COVID-19. [PMID:32296824] CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32566572", "protein_xref_biomarkerdb", "A0009" ], [ "P02741-1", "A0009", "C-reactive protein (CRP)", "increased CRP level", "monitoring", "71426-1", "Measured in serum (UN:0001977) and plasma (UN:0001969) as well.", "SAA/L, CRP, SAA, and L count are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] The positive correlations between CRP and series cancer biomarkers we showed in this study demonstrate that these cancer biomarkers can present the diffuse and acute lung injuries in COVID-19. CRP increased in 95% of all cases; the increases were significant for all groups (mild: 13.5\u2009\u00b1\u200913.1; severe: 35.0\u2009\u00b1\u200939.2; critical: 66.1\u2009\u00b1\u200967.3; in mg/L; P\u2009=\u2009.002). [PMID:32347972] Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] With following parameters such as age >67.5 years, IL2R >793.5U/mL, CRP >30.7ng/mL, ferroprotein >2252ug/L, WBC>9.5x10^9/L or NC >7.305x10^9/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. [PMID:33349241] Surveillance of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis, and treatment of COVID-19. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] NLR and CRP are potential and reliable predictors of COVID-19 prognosis and can triage patients at the time of admission. [PMID:32566572] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] We found that old age, and higher serum lactate dehydrogenase, C-reactive protein, the coefficient of variation of red blood cell distribution width, blood urea nitrogen, direct bilirubin, lower albumin, are associated with severe COVID-19. [PMID:32296824] CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32243911", "protein_xref_biomarkerdb", "A0009" ], [ "P02741-1", "A0009", "C-reactive protein (CRP)", "increased CRP level", "monitoring", "71426-1", "Measured in serum (UN:0001977) and plasma (UN:0001969) as well.", "SAA/L, CRP, SAA, and L count are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] The positive correlations between CRP and series cancer biomarkers we showed in this study demonstrate that these cancer biomarkers can present the diffuse and acute lung injuries in COVID-19. CRP increased in 95% of all cases; the increases were significant for all groups (mild: 13.5\u2009\u00b1\u200913.1; severe: 35.0\u2009\u00b1\u200939.2; critical: 66.1\u2009\u00b1\u200967.3; in mg/L; P\u2009=\u2009.002). [PMID:32347972] Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] With following parameters such as age >67.5 years, IL2R >793.5U/mL, CRP >30.7ng/mL, ferroprotein >2252ug/L, WBC>9.5x10^9/L or NC >7.305x10^9/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. [PMID:33349241] Surveillance of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis, and treatment of COVID-19. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] NLR and CRP are potential and reliable predictors of COVID-19 prognosis and can triage patients at the time of admission. [PMID:32566572] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] We found that old age, and higher serum lactate dehydrogenase, C-reactive protein, the coefficient of variation of red blood cell distribution width, blood urea nitrogen, direct bilirubin, lower albumin, are associated with severe COVID-19. [PMID:32296824] CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32475810", "protein_xref_biomarkerdb", "A0009" ], [ "P02741-1", "A0009", "C-reactive protein (CRP)", "increased CRP level", "monitoring", "71426-1", "Measured in serum (UN:0001977) and plasma (UN:0001969) as well.", "SAA/L, CRP, SAA, and L count are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] The positive correlations between CRP and series cancer biomarkers we showed in this study demonstrate that these cancer biomarkers can present the diffuse and acute lung injuries in COVID-19. CRP increased in 95% of all cases; the increases were significant for all groups (mild: 13.5\u2009\u00b1\u200913.1; severe: 35.0\u2009\u00b1\u200939.2; critical: 66.1\u2009\u00b1\u200967.3; in mg/L; P\u2009=\u2009.002). [PMID:32347972] Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] With following parameters such as age >67.5 years, IL2R >793.5U/mL, CRP >30.7ng/mL, ferroprotein >2252ug/L, WBC>9.5x10^9/L or NC >7.305x10^9/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. [PMID:33349241] Surveillance of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis, and treatment of COVID-19. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] NLR and CRP are potential and reliable predictors of COVID-19 prognosis and can triage patients at the time of admission. [PMID:32566572] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] We found that old age, and higher serum lactate dehydrogenase, C-reactive protein, the coefficient of variation of red blood cell distribution width, blood urea nitrogen, direct bilirubin, lower albumin, are associated with severe COVID-19. [PMID:32296824] CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32296824", "protein_xref_biomarkerdb", "A0009" ], [ "P02741-1", "A0009", "C-reactive protein (CRP)", "increased CRP level", "monitoring", "71426-1", "Measured in serum (UN:0001977) and plasma (UN:0001969) as well.", "SAA/L, CRP, SAA, and L count are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] The positive correlations between CRP and series cancer biomarkers we showed in this study demonstrate that these cancer biomarkers can present the diffuse and acute lung injuries in COVID-19. CRP increased in 95% of all cases; the increases were significant for all groups (mild: 13.5\u2009\u00b1\u200913.1; severe: 35.0\u2009\u00b1\u200939.2; critical: 66.1\u2009\u00b1\u200967.3; in mg/L; P\u2009=\u2009.002). [PMID:32347972] Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] With following parameters such as age >67.5 years, IL2R >793.5U/mL, CRP >30.7ng/mL, ferroprotein >2252ug/L, WBC>9.5x10^9/L or NC >7.305x10^9/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. [PMID:33349241] Surveillance of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis, and treatment of COVID-19. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] NLR and CRP are potential and reliable predictors of COVID-19 prognosis and can triage patients at the time of admission. [PMID:32566572] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] We found that old age, and higher serum lactate dehydrogenase, C-reactive protein, the coefficient of variation of red blood cell distribution width, blood urea nitrogen, direct bilirubin, lower albumin, are associated with severe COVID-19. [PMID:32296824] CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_doi", "10.1101/2020.03.10.20033613", "protein_xref_biomarkerdb", "A0009" ], [ "P02741-1", "A0009", "C-reactive protein (CRP)", "increased CRP level", "monitoring", "71426-1", "Measured in serum (UN:0001977) and plasma (UN:0001969) as well.", "SAA/L, CRP, SAA, and L count are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] The positive correlations between CRP and series cancer biomarkers we showed in this study demonstrate that these cancer biomarkers can present the diffuse and acute lung injuries in COVID-19. CRP increased in 95% of all cases; the increases were significant for all groups (mild: 13.5\u2009\u00b1\u200913.1; severe: 35.0\u2009\u00b1\u200939.2; critical: 66.1\u2009\u00b1\u200967.3; in mg/L; P\u2009=\u2009.002). [PMID:32347972] Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] With following parameters such as age >67.5 years, IL2R >793.5U/mL, CRP >30.7ng/mL, ferroprotein >2252ug/L, WBC>9.5x10^9/L or NC >7.305x10^9/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. [PMID:33349241] Surveillance of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis, and treatment of COVID-19. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] NLR and CRP are potential and reliable predictors of COVID-19 prognosis and can triage patients at the time of admission. [PMID:32566572] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] We found that old age, and higher serum lactate dehydrogenase, C-reactive protein, the coefficient of variation of red blood cell distribution width, blood urea nitrogen, direct bilirubin, lower albumin, are associated with severe COVID-19. [PMID:32296824] CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32281668", "protein_xref_biomarkerdb", "A0009" ], [ "P02741-1", "A0009", "C-reactive protein (CRP)", "increased CRP level", "monitoring", "71426-1", "Measured in serum (UN:0001977) and plasma (UN:0001969) as well.", "SAA/L, CRP, SAA, and L count are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] Elevated levels of IL-6, D-dimer, CRP, LDH, and ferritin all had an independent increased risk for the clinical outcomes assessed (ICU admission, invasive ventilatory support and death), which were statistically significant. [PMID:32677844] The positive correlations between CRP and series cancer biomarkers we showed in this study demonstrate that these cancer biomarkers can present the diffuse and acute lung injuries in COVID-19. CRP increased in 95% of all cases; the increases were significant for all groups (mild: 13.5\u2009\u00b1\u200913.1; severe: 35.0\u2009\u00b1\u200939.2; critical: 66.1\u2009\u00b1\u200967.3; in mg/L; P\u2009=\u2009.002). [PMID:32347972] Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] With following parameters such as age >67.5 years, IL2R >793.5U/mL, CRP >30.7ng/mL, ferroprotein >2252ug/L, WBC>9.5x10^9/L or NC >7.305x10^9/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. [PMID:33349241] Surveillance of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis, and treatment of COVID-19. [PMID:32161940] The maximal level of IL-6, followed by CRP level, was highly predictive of the need for mechanical ventilation. This suggests the possibility of using IL-6 or CRP level to guide escalation of treatment in patients with COVID-19-related hyperinflammatory syndrome. [PMID:32425269] NLR and CRP are potential and reliable predictors of COVID-19 prognosis and can triage patients at the time of admission. [PMID:32566572] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911] C-reactive protein, serum amyloid A, interleukin-6, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, D-dimer, cardiac troponin, and renal biomarkers showed significantly higher levels in patients with severe complications of COVID-19 infection compared to their non-severe counterparts. [PMID:32475810] We found that old age, and higher serum lactate dehydrogenase, C-reactive protein, the coefficient of variation of red blood cell distribution width, blood urea nitrogen, direct bilirubin, lower albumin, are associated with severe COVID-19. [PMID:32296824] CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32243911", "protein_xref_biomarkerdb", "A0009" ], [ "P02741-1", "A0009", "C-reactive protein (CRP)", "increased CRP level", "prognostic", "71426-1", "Measured in serum (UN:0001977) as well.", "The combination of eosinopenia and elevated hs-CRP can effectively triage suspected COVID-19 patients from other patients attending the fever clinic with COVID-19-like initial symptoms. [PMID:32368728] Patients with higher initial SAA are more likely to have poor CT imaging. Our study indicated that SAA/L. CRP, SAA, and l are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] CRP is one of the first biomarkers within blood plasma that changes to reflect physiological complications; if accepted CRP will be the most effective biomarker to predict the progression of COVID-19 infection. CRP values are more reliable for earlier identification of case severity. [PMID:32475810] CRP which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] Concentrations of CRP remained high in patients who died of COVID-19 infection, and CRP could be a biomarker for assessing disease lethality. [PMID:32511972] The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. [PMID:32344321] The serum levels of CRP, PCT and ferritin are markedly increased in very severe compared with severe COVID-19. [PMID:32615866] We propose that a few parameters, such Lymphocytes count, L/N ratio, SaO2 and CRP serum level can be used to assess the severity of COVID-19 in emergency room. [PMID:32471703] The plasma CRP level is positively correlated to the severity of COVID-19 on CT performance, and higher level of CRP showed a longer inpatient duration. [PMID:32414383] CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] The combinations of the hypoalbuminemia, lymphopenia, and high concentrations of CRP and LDH in 2019-nCoV infected patients upon hospital admission may predict more severe acute lung injury. [PMID:32048163] SAA/L, CRP, SAA, and l are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] Best baseline predictors of respiratory failure were suPAR with an AUC (95% CI) of 0.88 (0.80-0.95), EWS 0.84 (0.75-0.93), LDH 0.82 (0.71-0.93), and CRP 0.80 (0.70-0.89. [DOI:10.1101/2020.05.27.20114678] At the early stage of COVID-19, CRP levels were positively cor-related with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911] The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. [PMID:32344321]", "blood", "0000178", "0080600", "", "protein", "protein_xref_biomarkerdb", "A0009", "protein_xref_biomarkerdb", "A0009" ], [ "P02741-1", "A0009", "C-reactive protein (CRP)", "increased CRP level", "prognostic", "71426-1", "Measured in serum (UN:0001977) as well.", "The combination of eosinopenia and elevated hs-CRP can effectively triage suspected COVID-19 patients from other patients attending the fever clinic with COVID-19-like initial symptoms. [PMID:32368728] Patients with higher initial SAA are more likely to have poor CT imaging. Our study indicated that SAA/L. CRP, SAA, and l are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] CRP is one of the first biomarkers within blood plasma that changes to reflect physiological complications; if accepted CRP will be the most effective biomarker to predict the progression of COVID-19 infection. CRP values are more reliable for earlier identification of case severity. [PMID:32475810] CRP which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] Concentrations of CRP remained high in patients who died of COVID-19 infection, and CRP could be a biomarker for assessing disease lethality. [PMID:32511972] The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. [PMID:32344321] The serum levels of CRP, PCT and ferritin are markedly increased in very severe compared with severe COVID-19. [PMID:32615866] We propose that a few parameters, such Lymphocytes count, L/N ratio, SaO2 and CRP serum level can be used to assess the severity of COVID-19 in emergency room. [PMID:32471703] The plasma CRP level is positively correlated to the severity of COVID-19 on CT performance, and higher level of CRP showed a longer inpatient duration. [PMID:32414383] CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] The combinations of the hypoalbuminemia, lymphopenia, and high concentrations of CRP and LDH in 2019-nCoV infected patients upon hospital admission may predict more severe acute lung injury. [PMID:32048163] SAA/L, CRP, SAA, and l are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] Best baseline predictors of respiratory failure were suPAR with an AUC (95% CI) of 0.88 (0.80-0.95), EWS 0.84 (0.75-0.93), LDH 0.82 (0.71-0.93), and CRP 0.80 (0.70-0.89. [DOI:10.1101/2020.05.27.20114678] At the early stage of COVID-19, CRP levels were positively cor-related with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911] The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. [PMID:32344321]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32368728", "protein_xref_biomarkerdb", "A0009" ], [ "P02741-1", "A0009", "C-reactive protein (CRP)", "increased CRP level", "prognostic", "71426-1", "Measured in serum (UN:0001977) as well.", "The combination of eosinopenia and elevated hs-CRP can effectively triage suspected COVID-19 patients from other patients attending the fever clinic with COVID-19-like initial symptoms. [PMID:32368728] Patients with higher initial SAA are more likely to have poor CT imaging. Our study indicated that SAA/L. CRP, SAA, and l are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] CRP is one of the first biomarkers within blood plasma that changes to reflect physiological complications; if accepted CRP will be the most effective biomarker to predict the progression of COVID-19 infection. CRP values are more reliable for earlier identification of case severity. [PMID:32475810] CRP which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] Concentrations of CRP remained high in patients who died of COVID-19 infection, and CRP could be a biomarker for assessing disease lethality. [PMID:32511972] The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. [PMID:32344321] The serum levels of CRP, PCT and ferritin are markedly increased in very severe compared with severe COVID-19. [PMID:32615866] We propose that a few parameters, such Lymphocytes count, L/N ratio, SaO2 and CRP serum level can be used to assess the severity of COVID-19 in emergency room. [PMID:32471703] The plasma CRP level is positively correlated to the severity of COVID-19 on CT performance, and higher level of CRP showed a longer inpatient duration. [PMID:32414383] CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] The combinations of the hypoalbuminemia, lymphopenia, and high concentrations of CRP and LDH in 2019-nCoV infected patients upon hospital admission may predict more severe acute lung injury. [PMID:32048163] SAA/L, CRP, SAA, and l are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] Best baseline predictors of respiratory failure were suPAR with an AUC (95% CI) of 0.88 (0.80-0.95), EWS 0.84 (0.75-0.93), LDH 0.82 (0.71-0.93), and CRP 0.80 (0.70-0.89. [DOI:10.1101/2020.05.27.20114678] At the early stage of COVID-19, CRP levels were positively cor-related with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911] The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. [PMID:32344321]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32277967", "protein_xref_biomarkerdb", "A0009" ], [ "P02741-1", "A0009", "C-reactive protein (CRP)", "increased CRP level", "prognostic", "71426-1", "Measured in serum (UN:0001977) as well.", "The combination of eosinopenia and elevated hs-CRP can effectively triage suspected COVID-19 patients from other patients attending the fever clinic with COVID-19-like initial symptoms. [PMID:32368728] Patients with higher initial SAA are more likely to have poor CT imaging. Our study indicated that SAA/L. CRP, SAA, and l are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] CRP is one of the first biomarkers within blood plasma that changes to reflect physiological complications; if accepted CRP will be the most effective biomarker to predict the progression of COVID-19 infection. CRP values are more reliable for earlier identification of case severity. [PMID:32475810] CRP which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] Concentrations of CRP remained high in patients who died of COVID-19 infection, and CRP could be a biomarker for assessing disease lethality. [PMID:32511972] The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. [PMID:32344321] The serum levels of CRP, PCT and ferritin are markedly increased in very severe compared with severe COVID-19. [PMID:32615866] We propose that a few parameters, such Lymphocytes count, L/N ratio, SaO2 and CRP serum level can be used to assess the severity of COVID-19 in emergency room. [PMID:32471703] The plasma CRP level is positively correlated to the severity of COVID-19 on CT performance, and higher level of CRP showed a longer inpatient duration. [PMID:32414383] CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] The combinations of the hypoalbuminemia, lymphopenia, and high concentrations of CRP and LDH in 2019-nCoV infected patients upon hospital admission may predict more severe acute lung injury. [PMID:32048163] SAA/L, CRP, SAA, and l are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] Best baseline predictors of respiratory failure were suPAR with an AUC (95% CI) of 0.88 (0.80-0.95), EWS 0.84 (0.75-0.93), LDH 0.82 (0.71-0.93), and CRP 0.80 (0.70-0.89. [DOI:10.1101/2020.05.27.20114678] At the early stage of COVID-19, CRP levels were positively cor-related with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911] The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. [PMID:32344321]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32475810", "protein_xref_biomarkerdb", "A0009" ], [ "P02741-1", "A0009", "C-reactive protein (CRP)", "increased CRP level", "prognostic", "71426-1", "Measured in serum (UN:0001977) as well.", "The combination of eosinopenia and elevated hs-CRP can effectively triage suspected COVID-19 patients from other patients attending the fever clinic with COVID-19-like initial symptoms. [PMID:32368728] Patients with higher initial SAA are more likely to have poor CT imaging. Our study indicated that SAA/L. CRP, SAA, and l are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] CRP is one of the first biomarkers within blood plasma that changes to reflect physiological complications; if accepted CRP will be the most effective biomarker to predict the progression of COVID-19 infection. CRP values are more reliable for earlier identification of case severity. [PMID:32475810] CRP which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] Concentrations of CRP remained high in patients who died of COVID-19 infection, and CRP could be a biomarker for assessing disease lethality. [PMID:32511972] The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. [PMID:32344321] The serum levels of CRP, PCT and ferritin are markedly increased in very severe compared with severe COVID-19. [PMID:32615866] We propose that a few parameters, such Lymphocytes count, L/N ratio, SaO2 and CRP serum level can be used to assess the severity of COVID-19 in emergency room. [PMID:32471703] The plasma CRP level is positively correlated to the severity of COVID-19 on CT performance, and higher level of CRP showed a longer inpatient duration. [PMID:32414383] CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] The combinations of the hypoalbuminemia, lymphopenia, and high concentrations of CRP and LDH in 2019-nCoV infected patients upon hospital admission may predict more severe acute lung injury. [PMID:32048163] SAA/L, CRP, SAA, and l are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] Best baseline predictors of respiratory failure were suPAR with an AUC (95% CI) of 0.88 (0.80-0.95), EWS 0.84 (0.75-0.93), LDH 0.82 (0.71-0.93), and CRP 0.80 (0.70-0.89. [DOI:10.1101/2020.05.27.20114678] At the early stage of COVID-19, CRP levels were positively cor-related with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911] The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. [PMID:32344321]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32281668", "protein_xref_biomarkerdb", "A0009" ], [ "P02741-1", "A0009", "C-reactive protein (CRP)", "increased CRP level", "prognostic", "71426-1", "Measured in serum (UN:0001977) as well.", "The combination of eosinopenia and elevated hs-CRP can effectively triage suspected COVID-19 patients from other patients attending the fever clinic with COVID-19-like initial symptoms. [PMID:32368728] Patients with higher initial SAA are more likely to have poor CT imaging. Our study indicated that SAA/L. CRP, SAA, and l are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] CRP is one of the first biomarkers within blood plasma that changes to reflect physiological complications; if accepted CRP will be the most effective biomarker to predict the progression of COVID-19 infection. CRP values are more reliable for earlier identification of case severity. [PMID:32475810] CRP which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] Concentrations of CRP remained high in patients who died of COVID-19 infection, and CRP could be a biomarker for assessing disease lethality. [PMID:32511972] The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. [PMID:32344321] The serum levels of CRP, PCT and ferritin are markedly increased in very severe compared with severe COVID-19. [PMID:32615866] We propose that a few parameters, such Lymphocytes count, L/N ratio, SaO2 and CRP serum level can be used to assess the severity of COVID-19 in emergency room. [PMID:32471703] The plasma CRP level is positively correlated to the severity of COVID-19 on CT performance, and higher level of CRP showed a longer inpatient duration. [PMID:32414383] CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] The combinations of the hypoalbuminemia, lymphopenia, and high concentrations of CRP and LDH in 2019-nCoV infected patients upon hospital admission may predict more severe acute lung injury. [PMID:32048163] SAA/L, CRP, SAA, and l are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] Best baseline predictors of respiratory failure were suPAR with an AUC (95% CI) of 0.88 (0.80-0.95), EWS 0.84 (0.75-0.93), LDH 0.82 (0.71-0.93), and CRP 0.80 (0.70-0.89. [DOI:10.1101/2020.05.27.20114678] At the early stage of COVID-19, CRP levels were positively cor-related with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911] The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. [PMID:32344321]", "blood", "0000178", "0080600", "", "protein", "protein_xref_doi", "10.1038/s42256-020-0180-7", "protein_xref_biomarkerdb", "A0009" ], [ "P02741-1", "A0009", "C-reactive protein (CRP)", "increased CRP level", "prognostic", "71426-1", "Measured in serum (UN:0001977) as well.", "The combination of eosinopenia and elevated hs-CRP can effectively triage suspected COVID-19 patients from other patients attending the fever clinic with COVID-19-like initial symptoms. [PMID:32368728] Patients with higher initial SAA are more likely to have poor CT imaging. Our study indicated that SAA/L. CRP, SAA, and l are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] CRP is one of the first biomarkers within blood plasma that changes to reflect physiological complications; if accepted CRP will be the most effective biomarker to predict the progression of COVID-19 infection. CRP values are more reliable for earlier identification of case severity. [PMID:32475810] CRP which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] Concentrations of CRP remained high in patients who died of COVID-19 infection, and CRP could be a biomarker for assessing disease lethality. [PMID:32511972] The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. [PMID:32344321] The serum levels of CRP, PCT and ferritin are markedly increased in very severe compared with severe COVID-19. [PMID:32615866] We propose that a few parameters, such Lymphocytes count, L/N ratio, SaO2 and CRP serum level can be used to assess the severity of COVID-19 in emergency room. [PMID:32471703] The plasma CRP level is positively correlated to the severity of COVID-19 on CT performance, and higher level of CRP showed a longer inpatient duration. [PMID:32414383] CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] The combinations of the hypoalbuminemia, lymphopenia, and high concentrations of CRP and LDH in 2019-nCoV infected patients upon hospital admission may predict more severe acute lung injury. [PMID:32048163] SAA/L, CRP, SAA, and l are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] Best baseline predictors of respiratory failure were suPAR with an AUC (95% CI) of 0.88 (0.80-0.95), EWS 0.84 (0.75-0.93), LDH 0.82 (0.71-0.93), and CRP 0.80 (0.70-0.89. [DOI:10.1101/2020.05.27.20114678] At the early stage of COVID-19, CRP levels were positively cor-related with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911] The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. [PMID:32344321]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32511972", "protein_xref_biomarkerdb", "A0009" ], [ "P02741-1", "A0009", "C-reactive protein (CRP)", "increased CRP level", "prognostic", "71426-1", "Measured in serum (UN:0001977) as well.", "The combination of eosinopenia and elevated hs-CRP can effectively triage suspected COVID-19 patients from other patients attending the fever clinic with COVID-19-like initial symptoms. [PMID:32368728] Patients with higher initial SAA are more likely to have poor CT imaging. Our study indicated that SAA/L. CRP, SAA, and l are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] CRP is one of the first biomarkers within blood plasma that changes to reflect physiological complications; if accepted CRP will be the most effective biomarker to predict the progression of COVID-19 infection. CRP values are more reliable for earlier identification of case severity. [PMID:32475810] CRP which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] Concentrations of CRP remained high in patients who died of COVID-19 infection, and CRP could be a biomarker for assessing disease lethality. [PMID:32511972] The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. [PMID:32344321] The serum levels of CRP, PCT and ferritin are markedly increased in very severe compared with severe COVID-19. [PMID:32615866] We propose that a few parameters, such Lymphocytes count, L/N ratio, SaO2 and CRP serum level can be used to assess the severity of COVID-19 in emergency room. [PMID:32471703] The plasma CRP level is positively correlated to the severity of COVID-19 on CT performance, and higher level of CRP showed a longer inpatient duration. [PMID:32414383] CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] The combinations of the hypoalbuminemia, lymphopenia, and high concentrations of CRP and LDH in 2019-nCoV infected patients upon hospital admission may predict more severe acute lung injury. [PMID:32048163] SAA/L, CRP, SAA, and l are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] Best baseline predictors of respiratory failure were suPAR with an AUC (95% CI) of 0.88 (0.80-0.95), EWS 0.84 (0.75-0.93), LDH 0.82 (0.71-0.93), and CRP 0.80 (0.70-0.89. [DOI:10.1101/2020.05.27.20114678] At the early stage of COVID-19, CRP levels were positively cor-related with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911] The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. [PMID:32344321]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32344321", "protein_xref_biomarkerdb", "A0009" ], [ "P02741-1", "A0009", "C-reactive protein (CRP)", "increased CRP level", "prognostic", "71426-1", "Measured in serum (UN:0001977) as well.", "The combination of eosinopenia and elevated hs-CRP can effectively triage suspected COVID-19 patients from other patients attending the fever clinic with COVID-19-like initial symptoms. [PMID:32368728] Patients with higher initial SAA are more likely to have poor CT imaging. Our study indicated that SAA/L. CRP, SAA, and l are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] CRP is one of the first biomarkers within blood plasma that changes to reflect physiological complications; if accepted CRP will be the most effective biomarker to predict the progression of COVID-19 infection. CRP values are more reliable for earlier identification of case severity. [PMID:32475810] CRP which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] Concentrations of CRP remained high in patients who died of COVID-19 infection, and CRP could be a biomarker for assessing disease lethality. [PMID:32511972] The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. [PMID:32344321] The serum levels of CRP, PCT and ferritin are markedly increased in very severe compared with severe COVID-19. [PMID:32615866] We propose that a few parameters, such Lymphocytes count, L/N ratio, SaO2 and CRP serum level can be used to assess the severity of COVID-19 in emergency room. [PMID:32471703] The plasma CRP level is positively correlated to the severity of COVID-19 on CT performance, and higher level of CRP showed a longer inpatient duration. [PMID:32414383] CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] The combinations of the hypoalbuminemia, lymphopenia, and high concentrations of CRP and LDH in 2019-nCoV infected patients upon hospital admission may predict more severe acute lung injury. [PMID:32048163] SAA/L, CRP, SAA, and l are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] Best baseline predictors of respiratory failure were suPAR with an AUC (95% CI) of 0.88 (0.80-0.95), EWS 0.84 (0.75-0.93), LDH 0.82 (0.71-0.93), and CRP 0.80 (0.70-0.89. [DOI:10.1101/2020.05.27.20114678] At the early stage of COVID-19, CRP levels were positively cor-related with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911] The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. [PMID:32344321]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32615866", "protein_xref_biomarkerdb", "A0009" ], [ "P02741-1", "A0009", "C-reactive protein (CRP)", "increased CRP level", "prognostic", "71426-1", "Measured in serum (UN:0001977) as well.", "The combination of eosinopenia and elevated hs-CRP can effectively triage suspected COVID-19 patients from other patients attending the fever clinic with COVID-19-like initial symptoms. [PMID:32368728] Patients with higher initial SAA are more likely to have poor CT imaging. Our study indicated that SAA/L. CRP, SAA, and l are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] CRP is one of the first biomarkers within blood plasma that changes to reflect physiological complications; if accepted CRP will be the most effective biomarker to predict the progression of COVID-19 infection. CRP values are more reliable for earlier identification of case severity. [PMID:32475810] CRP which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] Concentrations of CRP remained high in patients who died of COVID-19 infection, and CRP could be a biomarker for assessing disease lethality. [PMID:32511972] The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. [PMID:32344321] The serum levels of CRP, PCT and ferritin are markedly increased in very severe compared with severe COVID-19. [PMID:32615866] We propose that a few parameters, such Lymphocytes count, L/N ratio, SaO2 and CRP serum level can be used to assess the severity of COVID-19 in emergency room. [PMID:32471703] The plasma CRP level is positively correlated to the severity of COVID-19 on CT performance, and higher level of CRP showed a longer inpatient duration. [PMID:32414383] CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] The combinations of the hypoalbuminemia, lymphopenia, and high concentrations of CRP and LDH in 2019-nCoV infected patients upon hospital admission may predict more severe acute lung injury. [PMID:32048163] SAA/L, CRP, SAA, and l are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] Best baseline predictors of respiratory failure were suPAR with an AUC (95% CI) of 0.88 (0.80-0.95), EWS 0.84 (0.75-0.93), LDH 0.82 (0.71-0.93), and CRP 0.80 (0.70-0.89. [DOI:10.1101/2020.05.27.20114678] At the early stage of COVID-19, CRP levels were positively cor-related with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911] The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. [PMID:32344321]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32471703", "protein_xref_biomarkerdb", "A0009" ], [ "P02741-1", "A0009", "C-reactive protein (CRP)", "increased CRP level", "prognostic", "71426-1", "Measured in serum (UN:0001977) as well.", "The combination of eosinopenia and elevated hs-CRP can effectively triage suspected COVID-19 patients from other patients attending the fever clinic with COVID-19-like initial symptoms. [PMID:32368728] Patients with higher initial SAA are more likely to have poor CT imaging. Our study indicated that SAA/L. CRP, SAA, and l are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] CRP is one of the first biomarkers within blood plasma that changes to reflect physiological complications; if accepted CRP will be the most effective biomarker to predict the progression of COVID-19 infection. CRP values are more reliable for earlier identification of case severity. [PMID:32475810] CRP which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] Biomarkers that predict the mortality of individual patients more than 10 days in advance with more than 90% accuracy: lactic dehydrogenase (LDH), lymphocyte and high-sensitivity C-reactive protein (hs-CRP). [DOI:10.1038/s42256-020-0180-7] Concentrations of CRP remained high in patients who died of COVID-19 infection, and CRP could be a biomarker for assessing disease lethality. [PMID:32511972] The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. [PMID:32344321] The serum levels of CRP, PCT and ferritin are markedly increased in very severe compared with severe COVID-19. [PMID:32615866] We propose that a few parameters, such Lymphocytes count, L/N ratio, SaO2 and CRP serum level can be used to assess the severity of COVID-19 in emergency room. [PMID:32471703] The plasma CRP level is positively correlated to the severity of COVID-19 on CT performance, and higher level of CRP showed a longer inpatient duration. [PMID:32414383] CRP changes before other blood parameters and thus may be an effective evaluation index for patients with COVID-19 infection. [DOI:10.1101/2020.03.10.20033613] CRP in severe COVID-19 patients increased significantly at the initial stage, before CT findings. Importantly, CRP, which was associated with disease development, predicted early severe COVID-19. [PMID:32281668] The combinations of the hypoalbuminemia, lymphopenia, and high concentrations of CRP and LDH in 2019-nCoV infected patients upon hospital admission may predict more severe acute lung injury. [PMID:32048163] SAA/L, CRP, SAA, and l are valuable in predicting the severity and distinguishing critically ill patients from mild ones. [PMID:32277967] Best baseline predictors of respiratory failure were suPAR with an AUC (95% CI) of 0.88 (0.80-0.95), EWS 0.84 (0.75-0.93), LDH 0.82 (0.71-0.93), and CRP 0.80 (0.70-0.89. [DOI:10.1101/2020.05.27.20114678] At the early stage of COVID-19, CRP levels were positively cor-related with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring. [PMID:32243911] The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19. [PMID:32344321]", "blood", "0000178", "0080600", "", "protein", "protein_xref_pubmed", "32414383", "protein_xref_biomarkerdb", "A0009" ] ] }, "readme": "Name\n - Human Protein Biomarkers (Biomarker Database)\n\nVersion\n - v-2.4.1\n\nCreated on\n - 2022-03-29T11:06:26.279356\n\nModified on\n - 2023-03-14T16:22:16.567Z\n\nCreated by\n - Jeet Vora [jeetvora@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Karina Martinez [karinamartinez@gwu.edu], Biomarker DB [], Luke Johnson [luke.johnson@email.gwu.edu], Urnisha Bhuiyan [sbhuiyan28@email.gwu.edu], Cyrus Au-Yeung [cyruschauyeung@gwu.edu], Jingyue Wu [jingyue.wu@email.gwu.edu]\n\nAuthors\n - \n\nChecksum\n - \n\nUsability Domain\n - This is a Human Protein Biomarkers dataset. It contains human [taxonomy:9606] protein biomarker information, including cross-mapped UniProtKB or Protein Ontology accessions, assessed biomarker entity, biomarker status, biomarker type, specimen type, LOINC code, disease name, and source evidence from the cancer biomarker portal (https://data.oncomx.org/cancerbiomarkers). This dataset can be used to obtain biomarker information for 19 cancer types and COVID-19. If you use this dataset, please provide proper attribution to OncoMX and GlyGen. Cite: PMID:32142370, PMID:34015823, and PMID:31616925. The dataset was earlier called as human_protein_cancer_biomarkers.csv\n\nDescription Domain\n Keywords\n - biomarker\n - cancer\n\n Pipeline Steps\n - Step-1: The script maps the UniProtKB accession from the source file to UniProtKB canonical accession. The script extracts the other fields as is from the source input file.\n\nExecution Domain\n Scripts - https://github.com/glygener/glygen-backend-integration/blob/master/dataset-maker/make-protein-dataset.py\n\n\n Software Prerequisites\n Name: Python\n Version: 2.7.5\n URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n Input Subdomain\n Name: doid2uberonid_mapping_v5.csv\n URI: https:/data.glygen.org/ln2releases/data/v-2.4.1/misc/doid2uberonid_mapping_v5.csv\n Name: sample_mapping.csv\n URI: https:/data.glygen.org/ln2releases/data/v-2.4.1/misc/sample_mapping.csv\n Name: allbiomarkers-all.csv\n URI: https:/data.glygen.org/ln2downloads/biomarkerdb/2023_08_11/allbiomarkers-all.csv\n Output Subdomain\n Name: human_protein_biomarkers.csv\n URI: https:/data.glygen.org/ln2releases/data/v-2.4.1/reviewed/human_protein_biomarkers.csv\n Name: human_protein_biomarkers.stat.csv\n URI: https:/data.glygen.org/ln2releases/data/v-2.4.1/reviewed/human_protein_biomarkers.stat.csv\n\nFields\n Name: \"uniprotkb_canonical_ac\"\n Description: \"\"\n Unique Values: \"310\"\n Name: \"biomarker_id\"\n Description: \"\"\n Unique Values: \"294\"\n Name: \"assessed_biomarker_entity\"\n Description: \"\"\n Unique Values: \"295\"\n Name: \"biomarker\"\n Description: \"\"\n Unique Values: \"289\"\n Name: \"best_biomarker_type\"\n Description: \"\"\n Unique Values: \"7\"\n Name: \"loinc_code\"\n Description: \"\"\n Unique Values: \"62\"\n Name: \"notes\"\n Description: \"Notes\"\n Unique Values: \"206\"\n Name: \"literature_evidence\"\n Description: \"\"\n Unique Values: \"378\"\n Name: \"anatomical_entity\"\n Description: \"\"\n Unique Values: \"21\"\n Name: \"uberon_id\"\n Description: \"\"\n Unique Values: \"21\"\n Name: \"do_id\"\n Description: \"Disease Ontology identifier\"\n Unique Values: \"22\"\n Name: \"do_name\"\n Description: \"Disease Ontology term or name for the disease assigned to the Disease Ontology identifier\"\n Unique Values: \"16\"\n Name: \"assessed_entity_type\"\n Description: \"\"\n Unique Values: \"10\"\n Name: \"xref_key\"\n Description: \"Source key associated to the xref_id\"\n Unique Values: \"3\"\n Name: \"xref_id\"\n Description: \"ID of the X-ref\"\n Unique Values: \"683\"\n Name: \"src_xref_key\"\n Description: \"Source Xref key\"\n Unique Values: \"1\"\n Name: \"src_xref_id\"\n Description: \"Source X-ref ID\"\n Unique Values: \"294\"", "downloadurl": "/ln2data/releases/data/v-2.4.1/reviewed/human_protein_biomarkers.csv" }