{ "bcoid": "GLY_000420", "title": "SARS-CoV2 Protein Enzyme Annotation (UniProtKB)", "description": "The SARS coronavirus (SARS-CoV-2 or 2019-nCov) Protein Enzyme Annotation (UniProtKB) dataset contains ...", "filename": "sarscov2_protein_enzyme_annotation_uniprotkb.csv", "filetype": "csv", "categories": { "species": [ "Severe acute respiratory syndrome coronavirus 2" ], "molecule": [ "Protein" ], "tag": [ "enzyme annotation" ], "file_type": [ "csv" ], "status": [ "Reviewed" ], "scope": [ "internal" ] }, "minitable": { "content": [ [ "P0DTD1-1...", "2.1.1.57..." ], [ "P0DTD1-1...", "3.1.13.-..." ] ], "headers": [ "uniprotkb_ca...", "enzyme_ec..." ], "colwidth": [ "40%", "20%" ] }, "sampledata": { "type": "table", "data": [ [ { "type": "string", "label": "uniprotkb_canonical_ac" }, { "type": "string", "label": "enzyme_ec" }, { "type": "string", "label": "enzyme_activity" } ], [ "P0DTD1-1", "2.1.1.57", "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine." ], [ "P0DTD1-1", "3.1.13.-", "" ], [ "P0DTD1-1", "2.7.7.48", "a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)." ], [ "P0DTD1-1", "3.4.19.12", "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)." ], [ "P0DTD1-1", "3.4.22.-", "" ], [ "P0DTD1-1", "3.6.4.12", "ATP + H2O = ADP + H(+) + phosphate." ], [ "P0DTD1-1", "2.1.1.56", "a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine." ], [ "P0DTD1-1", "3.6.4.13", "ATP + H2O = ADP + H(+) + phosphate." ], [ "P0DTD1-1", "2.7.7.50", "a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate." ], [ "P0DTD1-1", "4.6.1.-", "" ], [ "P0DTD1-1", "3.4.22.69", "TSAVLQ-|-SGFRK-NH2 and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position." ], [ "P0DTC1-1", "3.4.19.12", "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)." ], [ "P0DTC1-1", "3.4.22.-", "" ], [ "P0DTC1-1", "2.7.7.50", "a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate." ], [ "P0DTC1-1", "3.4.22.69", "TSAVLQ-|-SGFRK-NH2 and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position." ] ] }, "readme": "Name\n - SARS-CoV2 Protein Enzyme Annotation (UniProtKB)\n\nVersion\n - v-2.4.1\n\nCreated on\n - 2020-04-02T23:34:46.503960\n\nModified on\n - 2022-09-26T09:05:56.533134\n\nCreated by\n - Jeet Vora [jeetvora@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Karina Martinez [karinamartinez@gwu.edu], Luke Johnson [luke.johnson@email.gwu.edu], Urnisha Bhuiyan [sbhuiyan28@email.gwu.edu], Cyrus Au-Yeung [cyruschauyeung@gwu.edu], Jingyue Wu [jingyue.wu@email.gwu.edu]\n\nAuthors\n - Maria Martin [martin@ebi.ac.uk], Preethi Vasudev [pvasudev@ebi.ac.uk]\n\nChecksum\n - \n\nUsability Domain\n - The SARS coronavirus (SARS-CoV-2 or 2019-nCov) Protein Enzyme Annotation (UniProtKB) dataset contains sarscov2 [taxid:2697049] enzyme annotations for UniProtKB canonical accessions. The dataset contains ec numbers and enzyme activity that describes the enzymatic reactions. The dataset is derived form 2020-01 UniprotKB release. If you use this dataset please give proper attribution to UniProtKB and GlyGen\n\nDescription Domain\n Keywords\n - enzyme annotation\n - enzyme \n - UniProtKB\n - enzyme activity\n - EC number\n\n Pipeline Steps\n - Step-1: The script extracts the enzyme annotation triples from the triplestore for the UniProtKB canonical sequnces asnd extracts as a dataset in a csv format\n\nExecution Domain\n Scripts - https://github.com/glygener/glygen-backend-integration/blob/master/dataset-maker/make-protein-dataset.py\n\n\n Software Prerequisites\n Name: Python\n Version: 2.7.5\n URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n Input Subdomain\n Name: uniprot-proteome-sars-cov-2.nt\n URI: https:/data.glygen.org/ln2downloads/ebi/2024_02_13/uniprot-proteome-sars-cov-2.nt\n Output Subdomain\n Name: sarscov2_protein_enzyme_annotation_uniprotkb.csv\n URI: https:/data.glygen.org/ln2releases/data/v-2.4.1/reviewed/sarscov2_protein_enzyme_annotation_uniprotkb.csv\n Name: sarscov2_protein_enzyme_annotation_uniprotkb.stat.csv\n URI: https:/data.glygen.org/ln2releases/data/v-2.4.1/reviewed/sarscov2_protein_enzyme_annotation_uniprotkb.stat.csv\n\nFields\n Name: \"uniprotkb_canonical_ac\"\n Description: \"\"\n Unique Values: \"2\"\n Name: \"enzyme_ec\"\n Description: \"Enzyme Commision number assigned to an enzyme by Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB)\"\n Unique Values: \"11\"\n Name: \"enzyme_activity\"\n Description: \"The catalytic reaction activity of an enzyme in UniProtKB\"\n Unique Values: \"8\"", "downloadurl": "/ln2data/releases/data/v-2.4.1/reviewed/sarscov2_protein_enzyme_annotation_uniprotkb.csv" }